LOCUS       NZ_CP099738            23915 bp    DNA     circular CON 27-AUG-2024
DEFINITION  Lentzea sp. HUAS12 chromosome.
ACCESSION   NZ_CP099738
VERSION     NZ_CP099738.1
KEYWORDS    RefSeq.
SOURCE      Lentzea sp. HUAS12
  ORGANISM  Lentzea sp. HUAS12
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Lentzea.
REFERENCE   1  (bases 1 to 9676923)
  AUTHORS   Ping,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-JUN-2022) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024125735.1-RS_2024_08_27
            Annotation Date                   :: 08/27/2024 06:34:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,161
            CDSs (total)                      :: 9,080
            Genes (coding)                    :: 8,988
            CDSs (with protein)               :: 8,988
            Genes (RNA)                       :: 81
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 92
            CDSs (without protein)            :: 92
            Pseudo Genes (ambiguous residues) :: 0 of 92
            Pseudo Genes (frameshifted)       :: 21 of 92
            Pseudo Genes (incomplete)         :: 77 of 92
            Pseudo Genes (internal stop)      :: 3 of 92
            Pseudo Genes (multiple problems)  :: 8 of 92
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:47:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5039855
            Orig. end                         :: 5063770
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP099738.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Ping Mo.
FEATURES             Location/Qualifiers
     region          1..23915
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="25"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..23915
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23915
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:13915](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13915
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(327..1313)
                     /locus_tag="ND450_RS22325"
                     /old_locus_tag="ND450_22325"
     CDS             complement(327..1313)
                     /EC_number="3.5.99.7"
                     /GO_function="GO:0008660 -
                     1-aminocyclopropane-1-carboxylate deaminase activity
                     [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009310 - amine catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020498466.1"
                     /locus_tag="ND450_RS22325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22325"
                     /product="1-aminocyclopropane-1-carboxylate deaminase"
                     /protein_id="WP_253320710.1"
                     /sec_met_domain="PALP (E-value: 4.6e-45, bitscore: 153.3,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRFPLLFGPSPVHRLDRLTAHLGGAAVWAKREDCNSGLAYGGNK
                     TRKLEYLVADALATGCDTLVSIGGIQSNHTRQVAAAAARAGLKAVLVQESWVDWADVGS
                     DRVGNILLSRMMGADVRLVDAEFGIGVKPAWEQAIEEVRAAGGKPYPIPAGASDHPLGG
                     MGFANWADEVRQQEAQLGVFFDTIVVCSVTGSTQAGMVAGFANDTGRRVLGIDASAKPA
                     ETLAQITRIAHNTAKLREVTVSEEDILLDDRFHAGTYGIADDSTVDAMRLGASLEGMIT
                     DPVYEGKSLAGLIHLVSSGEIGRDSTVLYAHLGGQPALNAYSSLFPR"
     gene            complement(1310..1939)
                     /locus_tag="ND450_RS22330"
                     /old_locus_tag="ND450_22330"
     CDS             complement(1310..1939)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099104.1"
                     /locus_tag="ND450_RS22330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22330"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_253320711.1"
                     /transl_table=11
                     /translation="MQYIGYGSLKERAAAEIRSAIVRGDLEPGTPIKDVELAERLGLSR
                     TPVREALATLTDEGLVETKPHAYTRVTALEAEPVRDALVVVQSMHALAAGIAVPRMSDE
                     DIAAMRTANKAFKKALDADDAVAALAADDEFHAVAVRRCGNFAIAATIDRFTPLVRRAE
                     HSRFSSPNARHSVTQHQQIIEACEKGDAALVTTLVDENWSTLEEEL"
     gene            complement(2059..2622)
                     /locus_tag="ND450_RS22335"
                     /old_locus_tag="ND450_22335"
     CDS             complement(2059..2622)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099095.1"
                     /locus_tag="ND450_RS22335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22335"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_089924334.1"
                     /transl_table=11
                     /translation="MTASPRLERIVEMTAAELNERLGEALALYVTAMNYPPATVEQRAP
                     MWLAHMMREDWRCVVALGEQDELVGIGYGYRGAAGQWWHEQVRRGLMQVSPPAVVDEWL
                     TDYFELTELHVLPRAQGRGLGEDLLRRLMEGVPSSRVLLSTPEGPSKAWKLYRRVGFLD
                     VLRHYQFTGDPRPFAVLGRTLPIT"
     gene            complement(2619..3107)
                     /locus_tag="ND450_RS22340"
                     /old_locus_tag="ND450_22340"
     CDS             complement(2619..3107)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419640.1"
                     /locus_tag="ND450_RS22340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22340"
                     /product="YbaK/EbsC family protein"
                     /protein_id="WP_253320712.1"
                     /transl_table=11
                     /translation="MSSLEHPGIRKVAEALPAATAARIVVLPDAVRTAAAAAQAVGVQV
                     GAIANSLVFAAVRDGEAAPLLVLTSGAHRADTSLIAGLVGADAVKRADPEFVREHTGQV
                     IGGVSPVGHPAPIETVVDESLSGYDEIWAAAGHPHAVYPTTFADLVALTGGRVAAVAS"
     misc_feature    complement(3189..3204)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: medium, score: 24.24"
                     /tool="antismash"
     misc_feature    3190..3203
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.98"
                     /tool="antismash"
     gene            3311..3742
                     /locus_tag="ND450_RS22345"
                     /old_locus_tag="ND450_22345"
     CDS             3311..3742
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018686257.1"
                     /locus_tag="ND450_RS22345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22345"
                     /product="SAV_6107 family HEPN domain-containing protein"
                     /protein_id="WP_089924465.1"
                     /transl_table=11
                     /translation="MTADLSNPAAFPVPIPIPLPPASALALLRQARDSLAESERTPEPS
                     ERFATAYLAALRAAAAVLALRGRPHRGRSRPTSAWVLLGAIAPEMSEWAAFFASWSSTR
                     AAVLAGITRHVNARTADDLVRQTHLFVTLVDRVMSEARR"
     gene            3739..4485
                     /locus_tag="ND450_RS22350"
                     /old_locus_tag="ND450_22350"
     CDS             3739..4485
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099098.1"
                     /locus_tag="ND450_RS22350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22350"
                     /product="maleylpyruvate isomerase N-terminal
                     domain-containing protein"
                     /protein_id="WP_253320713.1"
                     /transl_table=11
                     /translation="MNLLDVLRREADLLAMSAIGQPPHKGVPACPGLNLGETVRHVGGG
                     YRGALAWIRLGREPEAGEWRDYPAPEEDPLEFMRSGAEAVIAELEAHGEDEPCATWWPD
                     RQDFGFWRRRLAHETTVHRMDVQGAAGMDVGAVDDEVAVDGVDEVLTLWLGHKLDVLGV
                     RGSRDSLVAIQVEDHLWLTRCGPQGASAWRVVDPEDAHAADAQVSASPMTMYRWLWGRL
                     PDRMVTTYGDDDAIAQLWALLRLATK"
     gene            complement(4462..6033)
                     /locus_tag="ND450_RS22355"
                     /old_locus_tag="ND450_22355"
     CDS             complement(4462..6033)
                     /EC_number="3.1.3.1"
                     /GO_function="GO:0004035 - alkaline phosphatase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800251.1"
                     /locus_tag="ND450_RS22355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22355"
                     /product="alkaline phosphatase D family protein"
                     /protein_id="WP_253320714.1"
                     /transl_table=11
                     /translation="MAKLVLGPLLRYVDDTSATLWVETDASCEVKIAGSTARTFQAGNQ
                     HYALVRLEGLGPRTEYDVELDGEKVWPEPGSEFPKPVIRTGQVRRIAFGSCRAAPDQPL
                     GPDALDAFAQRLMAVPEEEWPQAMILLGDQVYADEPTDSTKQWLRDRRKDTDEPDGEVV
                     HFGEYARLYHETWGDPEIRWLLSVVPTAMIFDDHDVRDDWNTSAAWRAQMAEKPWWRDR
                     IRGAISSYWVYQHLGNLSPAELAKNSLYAKVKAQGTDVLPMLLEFAEAADRETEGRKST
                     WWSFRREFGRIRLLMVDTRSGRILEEGKRQMINDDEFDWIEQNVDQADEYDHLLIGSSL
                     PWLMPHALSHFQSLNEIGANKPGWQGKAAEGIRQAVDLEHWPAFRESFDRLSRMIEKAG
                     NNGAATVCVLSGDVHHSYVAEAEFPSPTKAVVAQLVCSPIHNEAPKVLRPAFRFSWSRV
                     ASKIFRRLATWAGVPQDLVHWRKTSGPHFGNSIALLDVDGRLARYRLLSATGEETASVL
                     LGRETE"
     gene            6058..6552
                     /locus_tag="ND450_RS22360"
                     /old_locus_tag="ND450_22360"
     CDS             6058..6552
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037170.5"
                     /locus_tag="ND450_RS22360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22360"
                     /product="VOC family protein"
                     /protein_id="WP_253320715.1"
                     /transl_table=11
                     /translation="MEITFESADPPALAAFWSEFAGDEIELTFVWSDAPKIEKNWIHID
                     LASTSPEHQADIVARALKLGAEHADVGQADVPWVVLRDPQGNEFCVLEPRPEYPGVIAA
                     VVVDSRDPLASAEATGHPVARSGDGFASVRPEPGPWLEFVRTDDPEPITNRVRVRWADP
                     A"
     misc_feature    6059..6073
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.41"
                     /tool="antismash"
     misc_feature    6059..6074
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.79"
                     /tool="antismash"
     gene            complement(6601..8253)
                     /locus_tag="ND450_RS22365"
                     /old_locus_tag="ND450_22365"
     CDS             complement(6601..8253)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009943816.1"
                     /locus_tag="ND450_RS22365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22365"
                     /product="DUF885 domain-containing protein"
                     /protein_id="WP_253320716.1"
                     /transl_table=11
                     /translation="MASVHDISNKFVRDLVALDPITATSLGFSGSDDQLTDLSPEGHAA
                     RDELAVRALADVTGAQPADASEEAARAVFLERVGLEHEMYEAGVTESSLNVIASPIQSV
                     RDIFDQMPTDTPEQWATIGRRLAAVPAALDGLRASLSHAASRGNVSALRQVTKVAKQCD
                     TFATTFFGPFVASADVDGSVRSSLDAGASAASAAYADFASFLRTELAPKAPEKDAVGEE
                     RYRLGSRYFTGSKLDLAEAYAWGWEEFLGIEAEMKEVAARLKPGASLAETAAFLDENPR
                     YQVHGQDGLQAWMQELSDKALLDLRDVHFDLPDALMDLECRIAPPGGSVGAYYTQPTAD
                     FSRPGRMWWSIAEGKSVFPTWRETSTVYHEGVPGHHLQCATAVYQSATLNDFQRLLCWV
                     SGHGEGWALYAERLMRELGYLDDDADLLGMLDAHLFRAARVIIDIGMHLELEIPAGTGF
                     HPGERWTPELGLEFMLTRTLQEPAASRDELDRYLGWPGQAPSYKLGERLWLAAREDARA
                     RKGADFDLKRFHKEALEMGAMGLDTLRERLAAL"
     misc_feature    8404..8419
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     gene            8437..9015
                     /locus_tag="ND450_RS22370"
                     /old_locus_tag="ND450_22370"
     CDS             8437..9015
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099092.1"
                     /locus_tag="ND450_RS22370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22370"
                     /product="DUF3153 domain-containing protein"
                     /protein_id="WP_245786562.1"
                     /transl_table=11
                     /translation="MYAAMAVSEDDRISGEIVAATPPTQDNDPGPQLKVPPELESRVTT
                     KEYRVEQYAGTQLFFNGLTFDEMRTLSTATSSSNSRYSLNFRRSGDLVTLSGSVDLTQV
                     PVERADIQVKVSFPGKIVNTNGREEENNTIAWSPKPGQASMLQATVQYAGENSQSFFGW
                     ALLVAGLTGGAALIVVVLALIAHKRSALA"
     gene            complement(9051..9932)
                     /gene="metF"
                     /locus_tag="ND450_RS22375"
                     /old_locus_tag="ND450_22375"
     CDS             complement(9051..9932)
                     /EC_number="1.5.1.20"
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332694.1"
                     /locus_tag="ND450_RS22375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22375"
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_089924350.1"
                     /transl_table=11
                     /translation="MTSVVERLQGESPKFSVEFLPPRDAEDEKVLWKAVRELEGLDPAF
                     VSITYGAGGSRRDRTIRATGRIAQETTLLPVAHLTAVEHSVAELRNVIGWYAAIGVRNI
                     LALRGDPPGDPMGEWVAHPEGLSYADELVALVRELGDFCVGVAAFPYGHPRSTDLDTDL
                     KYLLRKLNAGADYAVAQLFHAPEPFLRMRDRVAAAGCSAAILPGIMPMLSPRGLAKIVE
                     LSGADLPLDVSRRLEPYADDVAGFRATGIDIATEMCQRLLDEGVPALHFYTMNRAKATR
                     EVLGRLGLVTRA"
     gene            10001..11104
                     /locus_tag="ND450_RS22380"
                     /old_locus_tag="ND450_22380"
     CDS             10001..11104
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099089.1"
                     /locus_tag="ND450_RS22380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22380"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_371927781.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 5.5e-45, bitscore:
                     152.7, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVSPDTADHGRVSHHPIDVALPQHVDEALTAYLASRRASGEAMD
                     PSFASAVDALSDFVLGGGKRIRPTYAWWGWRAAGGDPDGELAGEVLTAVSSLELIQACA
                     LIHDDLMDASSVRRGRPTVHIAFGARHREQGWLGSSERFGMSAAVLIGDVALAWADDML
                     FAAGLPPEVLRRMSEPWRDMRTEMLAGQYLDVLTQARGDSSPDAAVRIDRLKTAAYTVE
                     RPLHMGAAMAGASPELIGGLRAFGADIGVAFQLRDDLLGVFGDPEVTGKPAGDDLAEGK
                     RTLLVALGMQYGADILDIALGKPDLDLDTVEEVRRALVKVGAVDAVEERIEELTKSALA
                     ALDAAPVAEPAATKLADLAISSTKRTF"
     misc_feature    11278..11296
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            11298..12746
                     /gene="mptB"
                     /locus_tag="ND450_RS22385"
                     /old_locus_tag="ND450_22385"
     CDS             11298..12746
                     /codon_start=1
                     /gene="mptB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016696877.1"
                     /locus_tag="ND450_RS22385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22385"
                     /product="polyprenol phosphomannose-dependent alpha 1,6
                     mannosyltransferase MptB"
                     /protein_id="WP_253320718.1"
                     /transl_table=11
                     /translation="MRANTYAIPIRTTMLGLLGVALIALGGMGAGAILERDPLLAQVGL
                     SWLRYGHGRDLASMVLYLGLGLVIWAWIRLGRLVRWGEIGDFAVLVAVTVWTLPLLFAP
                     PLFSKDIYSYLAQGQLALSGYDPYTVGPAVLQSTLSENVSWVWQHTPAPYGPLFILVAK
                     AIVWITDASVILGVVAMRFSLAGGLVLLCWALPGLSRHLGGKSAIALWLVAANPLTLIH
                     LIGGAHNDLLMVGLMAAGVLLVLDRRHVLGFVLLALAFSVKATAVVVVPFLVWIWAARL
                     DGDKRAQFRKALVPGLVAFLGTFAVCTLVAGVNLGWIPALRSSSMIINWLSVPSAVGDF
                     VRMVVNWFVYVDGGIFIGVARALGSVVLIWIAYTQWWASRDGEVRDAIRRGALTMLAVA
                     LLSPATLPWYFSWPLALAAGFAWSTAGLVAVTIASLFLLLVTFPNGDTALYSWGYLFFA
                     LLVSALAARSLVKPDPFGLSSRYE"
     gene            12743..13915
                     /locus_tag="ND450_RS22390"
                     /old_locus_tag="ND450_22390"
     CDS             12743..13915
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012705.5"
                     /locus_tag="ND450_RS22390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22390"
                     /product="squalene/phytoene synthase family protein"
                     /protein_id="WP_371927393.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.9e-102,
                     bitscore: 341.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 4.4e-58,
                     bitscore: 195.9, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHGTVDLGDAYAACRRINARYGRTFFLATTLLRPDQRPAVHALY
                     AFARWADEIVDAAGVTDRAGELDRLERLLEKPPSNPVLHALADTRRRYDIDGSLFTDFL
                     ASMRMDLDVTEYADLDALGVYVHGSAEVIGLQMLPVLGTVVSREEAAPHAARLGVAFQL
                     TNFLRDVGEDLDRGRVYLPQDVLGAHGVDRDLLQWCRSHQRPDTRVRRVLDDLVAHSYA
                     IYRSAEPGIEMLSPASRPCVRTAYTLYRDILGLVGCEVLWRRVAVPNARRLAVALPGAG
                     RALVARLRTPGVGGAAVPGVGAAVSPGVGPGVDPVTATELTREVSPALNTEADPVPATA
                     VAPEGAAPTAAAGTHSVAGSDTASALNATPAVTPDVTPGVTAEASPGTSR"
     gene            complement(14068..14433)
                     /locus_tag="ND450_RS22395"
                     /old_locus_tag="ND450_22395"
     CDS             complement(14068..14433)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020657740.1"
                     /locus_tag="ND450_RS22395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22395"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_229905306.1"
                     /transl_table=11
                     /translation="MSAIPAAADVLAADLEVLPLPEVADRMGLPVTRVHQMLRDGQLLA
                     ERRNGVLVVPEAFLAAGTVVKGLPGTITVLRDQNFSTEEILRWLFTEDDSLPGTPIEAL
                     RGDRGREVKRRAQAMGF"
     gene            14511..16535
                     /gene="pknB"
                     /locus_tag="ND450_RS22400"
                     /old_locus_tag="ND450_22400"
     CDS             14511..16535
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010695258.1"
                     /locus_tag="ND450_RS22400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22400"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_253320719.1"
                     /sec_met_domain="Pkinase (E-value: 4e-47, bitscore: 159.8,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERSVSNVMGGLLEQRYRVDAVLARGGMSTVYRGRDTRLDRDVAI
                     KVMDPHLTADPAFVARFEREARAAAQLHHPAVVSVHDQGVDGDQVYLVMELIDGGNLRD
                     LLNQRGKLAPAVALSILGPVLSALGAAHRAGLVHRDVKPENVLIGPGGQVKVADFGLAR
                     AIGGNGVTSDSEILGTVAYLSPEQVETGTADARSDVYSAGIVLYEMLAGQAPYRGETPI
                     SVAYQHVNSDVPSVADVPLALDTLVRKATRRDPVLRPANADAFLAELERVGTELGLTPQ
                     PVPVPGSAPENDRTVIMRPVPVAVGATPPSAAELTRPVVPKPPLHSAMTTISTGPPTPP
                     PGIPASATRTMQRPEQPRRRPAQKRKSEAEKLEEERKRRKRLYTIWGAVAGVVVVAVGL
                     FTWYVSANRYTEMPSVAGQSEQNAQVLLSQADLTGLVEKVPSNDVPNGTVISSDPGPGA
                     ELRKNQQVKLVVSRGKPVVPFITAGTDEAVATKEIQAAGLKVTKDASKDAFHDTVPIGK
                     VVGIDPRPGTALNLDSPVTLIMSKGPPPRLPVPNVTGKTKTEADAELQRAGLEPVDAGG
                     DEAPENGNSRVVRTDPPAGTVLDPTQNKKVTVFYQNNSEVEVPDVSRKKVREAKEELER
                     AGLKVRVEFNKSNNATVVNQSIPPRTRVRRGTEITIVGL"
     gene            complement(16609..17997)
                     /locus_tag="ND450_RS22405"
                     /old_locus_tag="ND450_22405"
     CDS             complement(16609..17997)
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800237.1"
                     /locus_tag="ND450_RS22405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22405"
                     /product="class II 3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="WP_253320720.1"
                     /transl_table=11
                     /translation="MNWTVDVPIDTLPELPPLPPEMRKRLDDALSRPAAQQPEWPDAEQ
                     VRRVRTVLESVPPITVPAEIDRLHTQLAQVANGEAFLLQGGDCAETFADNTEPHIRANI
                     RTLLQMAVVLTYGASLPVVKVGRIAGQYAKPRSSGIDALGLPSYRGDIINSLVATPEAR
                     VADPGRMIRAYANAGAAMNLLRALTGAGLADLHRVHDWNRDFVRTSPAGERYEALAGEI
                     DRGLKFMSACGVNDQSLHGTEIFASHEALLLDYERALLRLDTNGEEPRLYDLSSHFLWI
                     GERTRQLDGAHIAFAEMLANPIGLKIGPTTTPEMAVEYVERLDPRNQPGRLTLISRMGN
                     QKVRDVLPAIVEKVEASGHKVIWQCDPMHGNTHESSTGYKTRHFDRIVDEVQGFFEVHR
                     RLGTHPGGIHIELTGEDVTECLGGAQEISDDDLAGRYETACDPRLNTQQSLELAFLVAE
                     MLRS"
     gene            18174..19181
                     /locus_tag="ND450_RS22410"
                     /old_locus_tag="ND450_22410"
     CDS             18174..19181
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022646.5"
                     /locus_tag="ND450_RS22410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22410"
                     /product="DUF2891 domain-containing protein"
                     /protein_id="WP_253320721.1"
                     /transl_table=11
                     /translation="MDATRLDDGTATRLLGIAIDNIQRDHPVHWTHVIDGDHRLVPQRV
                     LHPVFAGSFDWHSCVHQTWLAVRLLRLRPSLTGADTARNALDKLVTPDNCAVEAAFFAS
                     PAGRYWERPYGWAWLLLLDAELRTSDLPWSVAPIAEVLRDRWLEWISVARLPIRTGTHG
                     NTAFATSLVFDAARATGDTELATACAEAALRWHGDEAGYGGFEPDAADFLSPALTTADL
                     MRRALDPAAFADWFDAFLPDLEAERWRVLREPFPVDDPGDPYGSHLAGLALSRAWNWEA
                     VADALPDGHRYASLARTASAAHREAGWSYVFGGHGYMADHWLGTFGAYLDVKAF"
     gene            complement(19221..19985)
                     /locus_tag="ND450_RS22415"
                     /old_locus_tag="ND450_22415"
     CDS             complement(19221..19985)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013676255.1"
                     /locus_tag="ND450_RS22415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22415"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_253320722.1"
                     /transl_table=11
                     /translation="MTDVPNTLLGKVMSVLNAFGADDDELGFAELGRRTGLSKATLHRL
                     LGELAEVRLLDRGRRGYRLGSHLFQLGIRASVERRLVEVSTPYLEDLYERTHETVHLGL
                     LEGHEVVYAAKIGGHRQASSPSRLGGRMPLHATAIGKALLAHAPTGLRGEVLGSPLARL
                     TPRTAVTPGMLRQQLTKIRQTGVAYEFEESRVGLACVASPVLGDDGTAVAAVSVAGPTT
                     RFDPRTHAASVHAAATGIALTLVRRASLTSGH"
     gene            20066..20845
                     /locus_tag="ND450_RS22420"
                     /old_locus_tag="ND450_22420"
     CDS             20066..20845
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020417267.1"
                     /locus_tag="ND450_RS22420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22420"
                     /product="2-keto-4-pentenoate hydratase"
                     /protein_id="WP_253320723.1"
                     /transl_table=11
                     /translation="MNEVQTAAERLATAARDRITCAPVRDVIGDAEAYAVQQHNIAARV
                     AAGAKPVGRKIGLTAPAVRRQLGVDQPDFGVLLDDMAFKDGDVVPTERLLQPKVEAEVA
                     FVLKADLAEGPFDEQTVAAAVAYAQASLEIVDSRIENWNITFADTVADNASSALYVLGT
                     EQKELSEVTPRDVSAVLSVNGEERSTGAGADCMGDPLTALAWLAETAVRLGDPLRAGDV
                     VLSGALGPMVPVQAGDEVEATITGLGTVRATFAPEEA"
     gene            20846..21763
                     /locus_tag="ND450_RS22425"
                     /old_locus_tag="ND450_22425"
     CDS             20846..21763
                     /EC_number="1.2.1.10"
                     /GO_function="GO:0008774 - acetaldehyde dehydrogenase
                     (acetylating) activity [Evidence IEA]"
                     /GO_process="GO:0009056 - catabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013676256.1"
                     /locus_tag="ND450_RS22425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22425"
                     /product="acetaldehyde dehydrogenase (acetylating)"
                     /protein_id="WP_253320724.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 2.3e-07, bitscore:
                     30.5, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVAIIGSGNIGTDLVIKVLKRSSVLEVAALVGIDPESDGLAKAR
                     GLGVATTSDGIEGLVALPGFDEIEIVFDATSAGAHAKHAEVLAAHGKKVIDLTPAAIGP
                     MVVPTVNLDEHLDAPNVNMVTCGGQATIPVVAAINSVTPVPYAEIVASISSRSAGPGTR
                     ANIDEFTETTAQAIADVGGAKRGKAVIVLNPADPPITMRDTVLALVHAPDPETHEEIRE
                     SVERMISRVAAYVPGYRLKQNVQIDPVDQPATLTEEPVTHQVTVLLEVEGAADYLPAYA
                     GNLDIMTSAAVRVAETMAKAVVRA"
     gene            21760..22758
                     /gene="dmpG"
                     /locus_tag="ND450_RS22430"
                     /old_locus_tag="ND450_22430"
     CDS             21760..22758
                     /EC_number="4.1.3.39"
                     /GO_function="GO:0008701 - 4-hydroxy-2-oxovalerate aldolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009056 - catabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene="dmpG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011489333.1"
                     /locus_tag="ND450_RS22430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22430"
                     /product="4-hydroxy-2-oxovalerate aldolase"
                     /protein_id="WP_253320725.1"
                     /sec_met_domain="HMGL-like (E-value: 4.1e-63, bitscore:
                     212.4, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLYIQDVTLRDGMHALRHRIDPKKVAEIAKALDDAGVDAVEVSH
                     GDGLSGGSLVYGPGSHTDWEWIEAAAGALTGAKLTTLLLPGIGTLHDLKRAHGLGVQSV
                     RIATHCTEADISAQHIAGARDLGMDVSGFLMMSHLAEPQELARQAKLMESYGANCVYVT
                     DSGGRLLPKDVRDRIRAYKDVLDERTEIGIHAHENLSLAVANSIAAVEEGATRVDASLA
                     GLGAGAGNCPIEPFVAVANLQEWQHNADLFALQDAADDLVRPLMDRPVRVDRESLTLGY
                     AGVYGSFLRHADTAARRTGADVRTLLLEAGRRRLVGGQEDMLTDIALDLTR"
     gene            complement(22779..23708)
                     /locus_tag="ND450_RS22435"
                     /old_locus_tag="ND450_22435"
     CDS             complement(22779..23708)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013227515.1"
                     /locus_tag="ND450_RS22435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_22435"
                     /product="2,3-dihydroxyphenylpropionate 1,2-dioxygenase"
                     /protein_id="WP_253320726.1"
                     /transl_table=11
                     /translation="MAEIIGFAGMSHSPFATLLPPDGAGPGSVFLRDADRVRKAVDELA
                     PDAIVVIGPDHFHANFYDVMPPFVLGVEEAVGFGDFGSSSGPLPVERTLAWSAHGGLAG
                     AGFDVSLSYSLTVDHGIVQSYEMITGGTTLPLVPLVVNTAAPPLPSLDRCVGMGRALGA
                     ALRSSEFPGRVLVVASGGLSHWLPSNDPRDPSVVGERRESLIRGRAYVHEFAAAREPRV
                     KAMGGNPDARVNAAWDEWFLDRLVAGEAGEVASLGHEALEDHAGSGGHEIRCWLIGQVA
                     VGLPLVWTSYEPVPEWITGMGIGTTFPV"
     misc_feature    complement(23151..23153)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    23693..23707
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
ORIGIN
        1 cccggctggc cgcggcaggc ccggcgagct gggccggggc tgggttgggc ggggtgggcg
       61 gggctcgcac acctccggcc tcgatggact tggcgtgctc ctctcgcccc caaccgttgc
      121 tctcgcgctc ctcgcccggc gcgacaattc gccggtcacg cccgaaccgc cacgcgcccg
      181 gcccggctcg cccagctcag ccggctcgcc cggcccgctc ggctcggtcc ggcccagggc
      241 aacgctcccg cccacaacgt cacccgcgtc atccgcatca cccgcgtcgc ccccccaatc
      301 gagccccgcg cggtcccctc cccgaactac cgcgggaaca gcgagctgta ggcgttcaga
      361 gccggctgcc cgcccaggtg cgcgtacaac accgtggagt cgcgaccgat ctcccccgac
      421 gacacgaggt ggatgagccc cgccagcgac ttcccctcgt acaccgggtc ggtgatcatg
      481 ccctcgaggc tcgcacccag gcgcatggcg tccactgtgg agtcgtcggc gatgccgtag
      541 gtgccggcgt ggaagcggtc gtcgaggagg atgtcctctt cggacaccgt gacctcgcgc
      601 agcttggcgg tgttgtgcgc gatgcgggtg atctgggcga gggtctcggc gggcttggcg
      661 gaggcgtcga tgcccagcac gcggcggccg gtgtcgttcg cgaagcccgc gaccatgccc
      721 gcctgggtgc tgccggtgac cgagcagacg acgatcgtgt cgaagaagac gccgagctgc
      781 gcctcctgct ggcggacctc gtccgcccag ttcgcgaagc ccatgccgcc gagcgggtgg
      841 tcggaggctc cggcggggat cgggtagggc ttgccgccgg cggcgcggac ctcctcgatc
      901 gcctgttccc aggccggttt gacgccgatg ccgaactcgg cgtccaccag gcggacgtcg
      961 gctcccatca tgcggctgag caggatgttg ccgacgcggt cgctgcccac gtcggcccag
     1021 tcgacccagc tctcctgcac cagcacggcc ttgaggccgg cgcgggccgc ggcggccgct
     1081 acctggcggg tgtggttgga ctggatgcca ccgatcgaca cgagcgtgtc gcagccggtg
     1141 gccagcgcgt cggcgacgag gtactcgagc ttgcgggtct tgttgccgcc gtaggcgagg
     1201 ccggagttgc agtcttcgcg cttggcccag accgcggcgc cgccgaggtg tgcggtgagg
     1261 cggtcgaggc ggtggaccgg cgacggcccg aagagcagcg ggaatctggt cacagttcct
     1321 cttccagggt gctccagttc tcgtcgacca gcgtggtgac gagcgcggcg tcgcccttct
     1381 cgcacgcctc gatgatctgc tggtgctggg tgacggagtg gcgggcgttc ggtgaggaga
     1441 accggctgtg ctcggccctg cgcaccagcg gggtgaagcg gtcgatggtc gcggcgatcg
     1501 cgaagttgcc gcagcggcgg acggccaccg cgtggaactc gtcgtcggcg gccagcgcgg
     1561 cgacggcgtc gtcggcgtcg agcgccttct tgaaggcctt gttcgcggtg cgcatcgcgg
     1621 cgatgtcctc gtccgacatc ctcggcaccg cgatgccggc ggcgagggcg tgcatggact
     1681 gcacgacgac gagtgcgtcg cgcacgggtt cggcttccag cgcggtgaca cgggtgtagg
     1741 cgtgcggctt ggtctcgacc aggccttcgt cggtcagcgt cgcgagcgcc tcgcgcaccg
     1801 gggtgcggga caggccgagc cgctccgcca gctcgacgtc cttgatgggc gtgcccggct
     1861 cgaggtcacc gcgcacgatc gctgaccgga tctcggccgc cgcccgctcc ttcagtgacc
     1921 catatccaat atattgcata ttggtgagcg tagggacggg gtcaggtgat cgcaacccct
     1981 cgccgagcga cgatgagacg tccgcgcacg aaaacggcct gctcgacgac gtcgagcagg
     2041 ccggaaaagc cgggaggcct aggtgatcgg cagcgttcgg ccgaggaccg cgaacgggcg
     2101 cgggtcgccg gtgaactggt agtgccgcag cacgtccagg aagccgacgc ggcggtagag
     2161 cttccacgcc ttgctcgggc cttcgggggt ggacagcagc acgcgggagg acggcacgcc
     2221 ctccatgagc ctgcggagca ggtcctcgcc gaggccgcgg ccctgagcgc gcggcagcac
     2281 gtgcagttcg gtcagctcga agtagtcggt gagccattcg tcgacgacag cgggcggcga
     2341 cacctgcatc aggccgcgcc gcacctgttc gtgccaccac tggccggccg cgccgcggta
     2401 gccgtagccg atgccgacga gctcgtcctg ctcccccagc gcgacaacgc agcgccagtc
     2461 ctcgcgcatc atgtgcgcga gccacatcgg cgcgcgctgc tcgacggtgg cgggcgggta
     2521 gttcatcgcc gtcacgtaca gcgcgagcgc ctcgcccagc cgctcgttca gctccgcggc
     2581 cgtcatctcg acgatgcgct ccaggcgcgg cgaggccgtc atgacgccac cgccgcgacg
     2641 cgtccgcccg tcagcgccac caggtccgcg aaggtcgtgg ggtacacggc gtgcgggtgg
     2701 cccgcggccg cccagatctc gtcgtagccg gacagcgact cgtccaccac ggtctcgatc
     2761 ggcgccgggt gcccgaccgg ggacacaccg ccgatgacct ggcccgtgtg ctcgcggacg
     2821 aactcggggt cggcgcgctt gaccgcgtcc gcgcccacca gcccggcgat cagcgacgtg
     2881 tccgcgcggt gcgcgcccga cgtcaggacg agcagcgggg ccgcctctcc gtcgcgcacg
     2941 gcggcgaaga ccaggctgtt cgcgatcgcg ccgacctgca cgcccaccgc ctgcgccgcg
     3001 gccgccgcgg tccgcacggc gtccggcagc acgacgatgc gtgcggcggt ggcggccggg
     3061 agggcttccg ctaccttgcg gattccgggg tgttcgagcg agctcacgtc tccatcagac
     3121 cacgactcac gcccacgtgg tggggcgggt tgaggaatcc atcggctggg agctacgctg
     3181 atggagactc gaacatgtgt tcgagtctca ccatgcctcg gaggtggggt gggggaagca
     3241 ccccacctcc gagagccgcc ggcttcccct cggcggtgac gtcgttcacc gacgccacga
     3301 ggaggccgag atgacagccg atctttcgaa tccggcagcc ttccccgtcc ccatcccgat
     3361 tccgctgcca cccgcgtccg cgctcgccct gctccggcag gcccgcgact cgctcgccga
     3421 gtcggagcgc acgcccgagc cgtcggagcg gttcgcgacc gcctacctgg ccgcgttgcg
     3481 cgccgccgcc gcggtgctcg ccctgcgcgg acggccccat cgcgggcggt cgaggccgac
     3541 cagcgcctgg gtgctgctcg gcgcgatcgc gcccgagatg agcgagtggg ccgctttctt
     3601 cgcgtcgtgg tcgtccacgc gggccgccgt gctcgcgggg atcaccaggc acgtcaacgc
     3661 gcgcacggct gacgatctgg tgcgtcagac ccatctgttc gtgacgctcg tcgatcgcgt
     3721 gatgagcgag gcgaggcggt gaacctgctc gacgtgttgc gccgtgaggc ggatctgctc
     3781 gccatgtccg cgatcggcca gccgccgcac aagggcgtgc ccgcctgccc cgggctgaac
     3841 ctcggggaga ccgtgaggca cgtcggcggc ggctatcgcg gcgcactggc ctggatcagg
     3901 ctcggccgcg agcccgaggc cggggagtgg cgcgactacc cggcgccgga agaggatccg
     3961 ctcgagttca tgcggtcggg cgcggaggcc gtgatcgccg aactcgaggc gcacggggag
     4021 gacgagccgt gcgcgacgtg gtggcccgac cggcaggact tcgggttctg gcggcgacgg
     4081 ctggcgcacg agacgacggt gcaccgcatg gacgtgcagg gcgccgcggg catggacgtc
     4141 ggtgccgtcg acgacgaggt cgcggtcgac ggcgtcgacg aggtgctcac gttgtggctg
     4201 gggcacaagc tcgacgtgct cggggtgcgc gggtcgcggg acagcctcgt cgccatccag
     4261 gtcgaggacc acctgtggct cacgcggtgc ggcccgcagg gcgcgtcggc gtggcgcgtg
     4321 gtcgacccgg aggacgcgca cgccgccgac gcgcaggtgt cggcgagccc gatgacgatg
     4381 taccgctggc tgtggggacg gctgcccgac cgcatggtca cgacctacgg cgacgacgac
     4441 gcgatcgcgc agctgtgggc gctactccgt ctcgcgacca agtaggacgg acgcggtctc
     4501 ctcgcccgtc gccgacagca accggtagcg ggcgaggcgg ccgtcgacgt ccagcagcgc
     4561 gatcgagttc ccgaagtgcg ggccgctggt cttgcgccag tgcaccaggt cttgcgggac
     4621 accggcccac gtggccaggc ggcggaagat cttcgacgcc acgcgcgacc acgagaaccg
     4681 gaacgccggc cgcagcacct tcggcgcctc gttgtggatg ggcgagcaca cgagctgcgc
     4741 gaccaccgcc ttggtgggac tggggaactc ggcctcggcg acgtagctgt ggtggacgtc
     4801 gccggacagc acgcacaccg tcgcggcgcc gttgttgccg gccttctcga tcatgcgcga
     4861 gagccggtcg aacgactcgc ggaacgcggg ccagtgctcc aggtcgacgg cctgcctgat
     4921 gccctcggcc gccttgccct gccagcccgg cttgttcgcg ccgatctcgt tgagggactg
     4981 gaagtggctg agcgcgtgcg gcatcagcca cggcagcgac gagccgatca gcaggtggtc
     5041 gtactcgtcg gcctggtcga cgttctgctc gatccagtcg aactcgtcgt cgttgatcat
     5101 ctgccgcttg ccctcttcga ggatgcggcc ggagcgcgtg tcgaccatga gcagccggat
     5161 gcggccgaac tcgcggcgga agctccacca cgtcgacttg cggccctcgg tctccctgtc
     5221 ggccgcctcg gcgaactcca gcagcatcgg cagcacgtcc gtgccctggg ccttcacctt
     5281 ggcgtacaag gagttcttgg cgagctcggc cggactgagg ttgcccaggt gctggtagac
     5341 ccagtacgac gagatggcgc cgcggatcct gtcgcgccac cacggcttct ccgccatctg
     5401 cgcgcgccac gccgcggagg tgttccagtc gtcgcgcacg tcgtggtcgt cgaagatcat
     5461 cgcggtcggc accaccgaca gcagccagcg gatctccggg tcgccccagg tctcgtggta
     5521 gaggcgggcg tactcaccga agtggacgac ctcgccgtcg ggttcgtcgg tgtccttgcg
     5581 gcggtcgcgc agccactgct tcgtggagtc ggtgggctcg tcggcgtaga cctggtcccc
     5641 cagcaggatc atcgcctgcg gccactcctc ctccgggacg gccatgagcc gttgcgcgaa
     5701 cgcgtccagc gcgtccgggc cgagcggctg gtccggggcg gcgcggcacg acccgaaggc
     5761 gatccggcgg acctggcccg tgcggatgac cggtttcggg aactcgctgc cgggttccgg
     5821 ccagaccttc tcgccgtcga gttcgacgtc gtactcggtg cggggaccca gaccctcgag
     5881 ccggacgagc gcgtagtgct ggttgcccgc ctggaaagtg cgcgccgtgc tgccggcgat
     5941 cttcacctcg cacgaggcgt ccgtttcgac ccacaacgtc gcggacgtgt cgtcgacata
     6001 tctgaggagc ggtccgagca ccagcttcgc cacgcgcgag acagtaccct cgcacgcgtg
     6061 gaaatcacgt tcgagtcggc agatcccccg gcgctggccg cgttctggtc cgagttcgcg
     6121 ggcgacgaga tcgagctgac gttcgtgtgg agcgacgcgc cgaagatcga gaagaactgg
     6181 atccacatcg acctggcctc gacctcgccc gagcaccagg cggacatcgt cgcgcgggcg
     6241 ctcaagctcg gcgccgaaca cgccgacgtc ggtcaggccg acgtgccgtg ggtggtgctg
     6301 cgcgatccgc agggcaacga gttctgcgtc ctcgaacccc ggcccgagta ccccggcgtg
     6361 atcgccgccg tcgtcgtcga ctcgcgcgac ccgctggcgt ccgccgaggc gaccgggcac
     6421 ccggtggcgc gcagcggtga cgggttcgcc tcggtccgcc ccgagcccgg gccgtggctc
     6481 gagttcgtgc gcaccgacga cccggagccg atcacgaacc gcgtgcgcgt ccggtgggcc
     6541 gatccggcgt gaccgcccga gagcggccac gccactgata tccgatatat cggccgaggg
     6601 tcagagcgcg gccagtcgct cgcgcagggt gtcgaggccc atcgcgccca tctccagggc
     6661 ctccttgtgg aagcgcttga ggtcgaagtc ggcgcccttg cgggcccgcg cgtcctcgcg
     6721 cgccgcgagc cacaggcgct cgccgagctt gtacgagggc gcctgtcccg gccagccgag
     6781 gtagcggtcg agctcgtcgc gggaggcggc gggctcctgc agcgtgcggg tcagcatgaa
     6841 ctcgaggccg agctcggggg tccagcgctc gccggggtgg aagccggtgc cggccgggat
     6901 ctccagctcc aggtgcatgc cgatgtcgat gatgacgcgg gccgcgcgga acaggtgcgc
     6961 gtcgagcatg ccgagcaggt cggcgtcgtc gtcgaggtag ccgagctcgc gcatgaggcg
     7021 ttccgcgtag agcgcccagc cctcgccgtg gcccgacacc cagcacagga ggcgctggaa
     7081 gtcgttcaag gtcgccgact ggtacacggc cgtcgcgcac tggaggtggt ggcccggcac
     7141 gccctcgtgg tagaccgtcg aggtctcgcg ccaggtcggg aacaccgact tgccctcggc
     7201 gatcgaccac cacatgcggc cggggcggga gaagtccgcg gtcggctgcg tgtagtaggc
     7261 gccgacggaa ccgccgggcg gggcgatcct gcactcgagg tccatgagcg cgtccggcag
     7321 gtcgaagtgc acgtcgcgca ggtcgagcag ggccttgtcg gacagctcct gcatccacgc
     7381 ctgcaggccg tcctggccgt gcacctggta gcgcgggttc tcgtcgagga acgccgcggt
     7441 ctccgccagc gaggcgcccg gcttcagccg tgccgcgacc tccttcatct cggcctcgat
     7501 gccgaggaac tcctcccagc cccacgcgta ggcctcggcc aggtcgagct tcgaccccgt
     7561 gaagtagcgg gagccgaggc ggtagcgctc ctcgccgacc gcgtccttct ccggtgcctt
     7621 gggggcgagt tccgtgcgca ggaacgaagc gaagtccgcg tacgcggcgg aagcggcgga
     7681 ggcaccggcg tcgagagagg aacgcacgga accgtcgacg tcggcggacg cgacgaacgg
     7741 gccgaagaac gtcgtggcga acgtgtcgca ctgcttggcg accttggtga cctgacgcag
     7801 cgctgagacg ttgccgcgtg aggcggcgtg cgagagagag gcgcgcagac cgtccagagc
     7861 ggcgggcacg gcggcgaggc ggcggccgat cgtggcccac tgctccggcg tgtcggtcgg
     7921 catctggtcg aagatgtcgc gcaccgactg gatcgggctc gcgatgacgt tcagcgagga
     7981 ctcggtcaca cccgcctcgt acatctcgtg ctcgaggccc acccgttcga ggaagacggc
     8041 gcgggcggcc tcttccgagg catccgcggg ctgcgcgccg gtgacgtcgg cgagtgcgcg
     8101 gacggcgagt tcgtcgcgcg ccgcgtgtcc ttccggggag aggtccgtca gctggtcgtc
     8161 ggatcccgag aagccgagac tggtggcggt gatggggtcc agcgccacga ggtcgcggac
     8221 gaacttgttg ctgatgtcgt gcacggatgc catgttccgt gacgctacct cgcgcctctc
     8281 gacgccaaaa ggtagttagt caagctcacg accttcggag gggacctgcg tcgttcgggc
     8341 cgtgctggca ggatgtcggc cgtgcgtcgt tcccgggcac ttctgctgcc ggtcttcttg
     8401 ctgctcaccc tgttttcgct gagtggttgc gttcgcgtgt acgccgccat ggccgtctcg
     8461 gaggacgacc gcatctcggg tgagatcgtc gcggcgacac cgccgacgca ggacaacgac
     8521 cccggcccgc agctcaaggt gccgccggag ctcgagagcc gcgtcaccac caaggagtac
     8581 cgggtggagc agtacgcggg cacgcagctg ttcttcaacg gcctgacgtt cgacgagatg
     8641 cggactctgt cgacggcgac gagctcgtcg aacagccgct acagcctcaa cttccgccgg
     8701 tcgggtgatc ttgtcacgct gtcggggtcg gtcgacctga cccaggtgcc cgtggaacgc
     8761 gcggacatcc aggtcaaggt cagcttcccc ggcaagatcg tgaacaccaa cggccgcgag
     8821 gaggagaaca acacgatcgc gtggtctccg aagcccggcc aggcgtcgat gctgcaggcc
     8881 acagtgcagt acgcgggtga gaactcccag tcgttcttcg gctgggcgct gctggtcgcg
     8941 ggcctcaccg gcggtgccgc gctgatcgtg gtcgtgctcg ccctcatcgc gcacaagcgc
     9001 agtgcgcttg cttagggcgc ttgcttaggg cgctcgctta aggccctcgc tcaggcgcgg
     9061 gtgaccagac ccaggcgccc cagcacctcg cgcgtcgcct tcgccctgtt catcgtgtag
     9121 aagtgcagcg cgggaacgcc ctcgtcgagc aggcgctggc acatctcggt cgcgatgtcg
     9181 atgccggtcg cccggaaccc cgcgacgtcg tcggcgtacg gctccagccg gcgcgacacg
     9241 tcgagcggca ggtcggcacc ggacagctcc acgatcttgg cgaggccgcg cggcgacagc
     9301 atcggcatga tccccggcag gatcgccgcc gaacagcccg ccgccgccac ccggtcgcgc
     9361 atccgcagga acggctccgg cgcgtggaac agctgggcca ccgcgtagtc cgcgcccgcg
     9421 ttgagcttgc gcagcaggta cttcaggtcg gtgtcgaggt cggtggagcg cgggtgcccg
     9481 tacgggaacg ccgccacgcc cacgcagaag tcgccgagct cgcggaccag cgcgacgagt
     9541 tcgtcggcgt aggacaggcc ctcggggtgc gcgacccact cgcccatcgg gtcgccggga
     9601 gggtcgcctc gcagcgcgag gatgttccgc acgccgatcg ccgcgtacca gccgatgacg
     9661 ttgcgcagct cggccacgga gtgctcgacg gccgtgaggt gcgcgacggg gagcagcgtc
     9721 gtctcctgcg ctatccggcc ggtggcgcgg atcgtgcggt cgcggcgcga cccgccggcg
     9781 ccgtaggtga tcgagacgaa cgccgggtcg aggccttcca gttcgcggac ggccttccac
     9841 aggaccttct cgtcctccgc gtcccggggt ggcaggaact ccaccgagaa cttgggtgac
     9901 tccccctgga gccgctccac caccgacgtc atgacaccaa ccctagtggt acttccgcca
     9961 ggtgggacac gggctcacca tgtggaacgc atgccccgac atgcgggtgt ccccggacac
    10021 agcggaccat ggacgggtgt cccaccaccc aatcgatgtt gccctgcccc agcacgtcga
    10081 cgaagcgctg accgcttatc tggcctcccg gcgcgcgtcc ggcgaggcga tggacccgag
    10141 tttcgcgagc gcggtcgacg cgctctccga cttcgtgctg ggcggcggca agcgcatccg
    10201 cccgacctac gcgtggtggg gctggcgcgc ggccgggggc gaccccgacg gcgagctcgc
    10261 gggcgaggtg ctcacggccg tcagctcgct ggagctgatc caggcgtgcg cgctgatcca
    10321 cgacgacctg atggacgcct cgtcggtgcg ccggggcagg ccgaccgtgc acatcgcgtt
    10381 cggcgcgcgg caccgcgagc agggctggct ggggtcctcg gagcggttcg gcatgtcggc
    10441 ggccgtgctg atcggcgacg tcgcgctggc gtgggcggac gacatgctct tcgccgccgg
    10501 gctgccgccg gaggtgctgc gccggatgag cgagccgtgg cgggacatgc gcaccgaaat
    10561 gctcgcgggc cagtacctcg acgtgctcac gcaggcgcgg ggcgactcgt ccccggacgc
    10621 cgcggtgcgc atcgaccggc tcaagaccgc cgcgtacacc gtcgaacggc cgctgcacat
    10681 gggcgcggcg atggcgggag cgtcgcccga gctgatcggc gggctgcgcg cgttcggtgc
    10741 cgacatcggc gtcgcgttcc agctgcgcga cgacctgctc ggcgtgttcg gcgaccccga
    10801 ggtcaccggc aagcccgcgg gcgacgacct cgccgaggga aagcgcacgc tgctcgtcgc
    10861 gctgggcatg cagtacggcg ccgatatatt ggatatcgct ctcggcaagc ccgacctcga
    10921 cctcgacacc gtcgaggagg tccggcgggc gctcgtgaag gtcggcgccg tcgacgccgt
    10981 cgaggagcgc atcgaggagc tgacgaagag cgcgctggcc gccctcgacg ccgcacccgt
    11041 ggccgagccg gccgccacca agctcgccga cctcgcgatc agctcgacga agcggacctt
    11101 ctgaagtcga tcatcttcac cgttgctcca ctcggctccc ctcacggttc ctgagagttg
    11161 gttaactcct cgtcaccgtg tggcccgttg cctgctgacg cttccgcgcc ttgtgcaacg
    11221 atgttcgggc gatggcagca actccgtccc tcccccgcac gagctccgag gcgtcgatac
    11281 aggagcttca accagtcgtg cgcgcgaaca cctacgccat ccccatccgc acgaccatgc
    11341 tcggtctgct gggcgtggcg ctgatcgcgc tcgggggaat gggtgccggc gcgatcctcg
    11401 agcgcgaccc gctgctcgcc caggtcgggc tgagctggct gcgctacggc cacggccgcg
    11461 acctggcgag catggtcctg tacctgggcc tgggtctcgt catctgggcg tggatccggc
    11521 tcggccgcct cgtgcggtgg ggtgagatcg gcgacttcgc ggtgctggtc gcggtgacgg
    11581 tctggacgtt gccgctgctg ttcgcgccac cgctgttcag caaggacatc tacagctacc
    11641 tggcgcaggg ccagctcgcg ctcagcggct acgacccgta cacggtcggg cccgccgtcc
    11701 tgcagagcac gctgtccgag aacgtgagct gggtgtggca gcacacgccg gcgccgtacg
    11761 ggccgttgtt catcctggtc gcgaaggcga tcgtgtggat cacggacgcg agcgtcatcc
    11821 tcggcgtcgt ggccatgcgc ttctccctgg cgggcggcct cgtgctgttg tgctgggcgc
    11881 tgccgggcct gagcaggcac ctgggcggca agtcggcgat cgcgctgtgg ctggtcgcgg
    11941 cgaacccgct gaccctgatc cacctgatcg gcggcgcgca caacgacctg ctcatggtcg
    12001 gcctgatggc cgcgggcgtg ctgctggtgc tcgaccgcag gcacgtgctc gggttcgtgc
    12061 tgctcgccct cgcgttctcg gtgaaggcga cggcggtcgt ggtcgtgccg ttcctcgtgt
    12121 ggatctgggc cgcgcgcctc gacggcgaca aacgcgccca gttccgcaag gcgctggtgc
    12181 ccggcctggt cgcgttcctc gggacgttcg ccgtgtgcac gctcgtcgcc ggggtgaacc
    12241 tcggctggat cccggcgctg cgcagctcgt cgatgatcat caactggctg tcggtgccga
    12301 gcgcggtcgg cgacttcgtg cgcatggtcg tgaactggtt cgtctacgtc gacggcggca
    12361 tcttcatcgg cgtcgcgcgg gccctgggct ccgtggtcct gatctggatc gcgtacacgc
    12421 agtggtgggc gtcgcgcgac ggcgaggtgc gcgacgcgat ccgccgcggc gcgctgacga
    12481 tgctggccgt ggcgctgctc tcgcccgcga cgctgccctg gtacttcagc tggccgctgg
    12541 cgctcgccgc cgggttcgcg tggagcacgg cgggcctggt cgcggtgacg atcgcgtcgc
    12601 tgttcctgct gctggtgacg ttcccgaacg gcgacacggc gctgtactcg tggggctacc
    12661 tgttcttcgc gctgctggtg tcggcactcg cggcgcggtc gctggtgaag ccggacccgt
    12721 tcggcctgtc ctcccgctac gaatgagcca cggcaccgtg gacctgggcg acgcctatgc
    12781 cgcgtgccgc cgcatcaacg cgcggtacgg caggacgttc ttcctggcga cgacgctgct
    12841 gcgccccgat cagcggcccg cggtgcacgc cctctacgcg ttcgcccggt gggccgacga
    12901 gatcgtcgac gcggccgggg tgaccgaccg cgcgggtgag ctggaccgcc tggaacgcct
    12961 gctggagaag ccgccgtcga acccggtcct gcacgcactg gcggacacga ggcgccgcta
    13021 cgacatcgac gggtcgctgt tcaccgactt cctcgcgtcg atgcggatgg acctcgacgt
    13081 gaccgagtac gccgacctcg acgccctcgg cgtctacgtg cacggctcgg cggaggtcat
    13141 cggcctgcag atgctgccgg tgctcggcac cgtggtgtcc cgcgaggagg ccgcaccgca
    13201 cgcggcccgg ctcggggtgg cgttccagct cacgaacttc ctgcgcgacg tcggcgagga
    13261 cctcgaccgc ggtcgcgtct acctgccgca ggacgtcctc ggcgcgcacg gcgtcgaccg
    13321 cgacctcctg cagtggtgcc gctcgcacca gcgcccggac actcgcgtgc gacgggtgct
    13381 cgacgacctc gtcgcacact catatgcgat atatcggtcg gcggagccgg ggatcgagat
    13441 gctgtcgccg gcgtcgcggc cctgtgtgcg gactgcatac acgttgtatc gcgacatcct
    13501 cgggctcgtg ggctgcgagg tgttgtggcg gcgggtggcg gtgccgaacg cgcgtcggct
    13561 cgcggtggcg ctgccgggcg ccggcagggc cctcgtggcg cggctgagga cgccgggggt
    13621 gggtggagcg gcggtgccgg gggtgggggc cgcggtgagt ccgggagtgg gcccaggagt
    13681 cgacccggtg accgccacag agctgactcg agaggtcagc ccggcgctga acacggaggc
    13741 cgacccggta ccggccacgg cggtggcccc agaaggcgcg gcgccgaccg cagcggcggg
    13801 cacgcacagc gtcgcggggt ccgacacggc gtcagccctg aacgcaacgc ccgcggtgac
    13861 cccggatgtg acccccggcg tcaccgcgga agcgtcaccg gggacgtcga ggtgagcccc
    13921 gctttaggga cgcgcgaagg ttcggcccac tggggttcgg ccgggtgtgg ttcggccggg
    13981 tgtggttcgg cccggcgtgg ttcggcgcag cggggctccg ggcatctccc acctgcgaag
    14041 acgcccggaa ccgctgctgt cggtgtctca gaaacccatg gcctgcgcgc gtcgctttac
    14101 ctcgcgccca cggtctccgc gcaatgcttc gatcggagtg ccagggaggc tgtcgtcctc
    14161 cgtgaagagc cagcgcagga tctcctcggt ggagaagttc tggtcgcgca gcaccgtgat
    14221 ggtgccgggc agacccttca ccacggttcc ggcggcgagg aacgcctcgg gaacgacgag
    14281 gacgccgttc cgccgctcgg cgagcagttg cccgtcgcgc agcatttggt ggacccgggt
    14341 gaccggaagt cccattcggt cggccacctc ggggagagga agaacctcca ggtcggcagc
    14401 cagtacatcc gcagcggcag gaatcgcact cacgggggtc acgatgccat aaccgaactg
    14461 ggaacgccct tccgccaacc gggtcatcct gagctttacc atctcgcact gtggagaggt
    14521 cggtttcgaa cgtgatgggt ggactgctgg agcagcgcta ccgggtggac gccgtgctgg
    14581 cgcgaggcgg catgtccacc gtctatcgag gtcgtgacac ccgcctcgat cgcgatgtcg
    14641 ccatcaaggt gatggatcct cacctgaccg cggaccccgc gttcgtggcg cgcttcgagc
    14701 gcgaggcgcg ggccgcggcc cagctgcacc acccggccgt ggtgtccgtg cacgaccagg
    14761 gcgtcgacgg tgaccaggtg tacctggtga tggagctgat cgacggcggc aacctccgtg
    14821 acctgctcaa ccagcgcggc aagctcgctc ccgccgtcgc gttgagcatc ctcggccccg
    14881 tgttgtcggc gttgggcgcg gctcaccgcg ccgggctcgt gcaccgggac gtgaagccgg
    14941 agaacgtgct gatcggaccc ggtggccagg tcaaggtggc ggacttcggg ctggcccgcg
    15001 cgatcggcgg gaacggtgtc acgagtgaca gcgagatcct cggcaccgtc gcctatctgt
    15061 cacccgaaca ggtggagacc ggcacggcgg acgcgcgcag tgacgtctac tcggccggga
    15121 tcgtgctcta cgagatgctg gccggtcagg cgccctaccg cggcgagacg cccatctcgg
    15181 tggcctacca gcacgtgaac tcggacgtcc cgtcggtcgc ggacgtcccg ctggcgctcg
    15241 acacgctcgt gcgcaaggcc acgcggcgcg acccggtgct gcggcccgcg aacgccgacg
    15301 cgttcctggc cgagctggag cgcgtgggca cggagctggg cctcacgccg cagccggtgc
    15361 ccgttcccgg ttcggcgccc gagaacgaca ggacggtcat catgcgaccg gtgcccgtcg
    15421 ccgtcggcgc cactcccccg tcggccgccg agctgaccag gccggtcgtg ccgaagccgc
    15481 cgctccactc ggcgatgacg acgatcagca ccggcccgcc gacgcctcct cccggcatcc
    15541 cggcctcggc gacgcgcacg atgcagcggc cggagcagcc gcgccgccgg cccgcgcaga
    15601 agcggaagtc ggaggccgag aagctcgagg aggagcgcaa gcggcgcaag cggctctaca
    15661 cgatctgggg cgccgtggcc ggcgtcgtgg tggtcgcggt cgggctgttc acctggtacg
    15721 tctccgccaa ccgctacacg gagatgccgt cggtggcggg gcagtccgag cagaacgcgc
    15781 aggtgctgct ctcgcaggcg gacctcaccg gcctcgtcga gaaggtgccg tccaacgacg
    15841 tccccaacgg cacggtcatc agctccgacc ccggtcccgg cgcggagctg cgcaagaacc
    15901 agcaggtcaa gctggtcgtg tcgcgcggca agcccgtggt gccgttcatc accgccggta
    15961 ccgacgaggc cgtggcgacc aaggagatcc aggccgcggg cctgaaggtc accaaggacg
    16021 cctcgaagga cgcgttccac gacaccgtgc ccatcggcaa ggtcgtgggc atcgacccgc
    16081 gtcccggcac ggcgctcaac ctcgactcgc cggtcaccct gatcatgagc aagggcccgc
    16141 cgccgcgcct gccggtgccg aacgtcaccg gcaagacgaa gaccgaggcg gacgccgaac
    16201 tgcagcgcgc cggtctggag ccggtcgacg cggggggcga cgaggccccg gagaacggca
    16261 actcgcgcgt ggtgcggacg gacccgcccg cgggcacggt gctggacccg acccagaaca
    16321 agaaggtcac ggtcttctac cagaacaaca gcgaggtcga ggtgcccgac gtctcccgca
    16381 agaaggtgcg cgaggcgaag gaggagctcg aacgggccgg tctgaaggtg agggtcgagt
    16441 tcaacaagag caacaacgcg accgtcgtga accagtcgat ccccccgcgc acgcgggtga
    16501 ggcggggaac cgagatcacc atcgtcggcc tctgaccggt tcgaagcgaa gggccccgcg
    16561 ttctcgacgc ggggcccttc gttcttcagc tcgtcttcag tgaacccgtc aggagcgcag
    16621 catctcggcg acgaggaacg cgagctcgag cgactgctgc gtgttcagac gcgggtcgca
    16681 cgccgtctcg tagcggccgg cgaggtcgtc gtccgagatc tcctgggcgc cgccgaggca
    16741 ctcggtgacg tcctcacccg tgagctcgat gtggatgccg ccggggtgcg tgccgagacg
    16801 gcggtgcacc tcgaagaagc cctggacctc gtcgacgatg cggtcgaagt gccgggtctt
    16861 gtagccggtc gacgactcgt gcgtgttgcc gtgcatcggg tcgcactgcc agatgacctt
    16921 gtggccgctg gcctcgacct tctccacgat ggcggggagc acgtcgcgca ccttctggtt
    16981 gcccatgcgc gagatgagcg tcaggcggcc cggctggttg cgcgggtcga ggcgctcgac
    17041 gtactcgacg gccatctccg gcgtcgtcgt cgggccgatc ttgagaccga tcgggttcgc
    17101 caacatctcg gcgaacgcga tgtgcgcgcc gtcgagctga cgggtgcgct caccgatcca
    17161 caggaagtgc gacgacaggt cgtagagccg gggctcctcg ccgttcgtgt cgaggcggag
    17221 cagcgcgcgc tcgtagtcga gcagcagcgc ctcgtgcgag gcgaagatct ccgtgccgtg
    17281 cagcgactgg tcgttcacgc cgcacgcgga catgaacttg aggccgcggt cgatctcgcc
    17341 ggccagggcc tcgtagcgct cgccggcggg cgaggtgcgc acgaagtcgc ggttccagtc
    17401 gtgcacgcgg tgcaggtcgg cgagacccgc gccggtgagg gcgcgcagca ggttcatggc
    17461 cgcgccggcg ttcgcgtagg cgcggatcat gcgaccgggg tcggcgacgc gggcttccgg
    17521 cgtcgcgacc agggagttga tgatgtcgcc gcggtaggac ggcaggccga gggcgtcgat
    17581 gccggacgaa cgcggcttgg cgtactggcc ggcgatgcgg ccgaccttca ccacgggaag
    17641 gctcgcgccg taggtcagca ccacggccat ctgcagcagg gtccggatgt tcgcgcggat
    17701 gtgcggctcg gtgttgtcag cgaacgtctc cgcgcagtca ccgccctgca ggagaaacgc
    17761 ctcaccgttc gcgacctgcg ccagttgcgt gtgcagccgg tcgatctcgg cgggcacggt
    17821 gatcggcggc acgctctcga gcacggtccg cacgcgacgc acctgttcgg cgtcgggcca
    17881 ttcgggctgc tgggcggccg ggcgcgacag ggcgtcgtcc aggcgcttgc gcatctcggg
    17941 aggcagcggc ggaagctcgg gaagcgtgtc gatgggcacg tccacggtcc agttcacgct
    18001 gctcatccta gttgtcccac actgagagac cgggccgggc ctgtcagcgg ttccaggggt
    18061 gcggaccagg cgtcatccgg cgtagcgggc gttacccccg gccgagtgag gtctgttact
    18121 tgtcaactat ctccctctgc ccaatcgaga tgccgcactg catgatgtgg gccatggatg
    18181 ccacccgatt ggatgacggc accgcgaccc ggctgctggg catcgcgatc gacaacatcc
    18241 agcgcgacca cccggtccac tggacgcacg tgatcgacgg ggaccaccgg ctcgtgccgc
    18301 agcgggtgct gcacccggtg ttcgccgggt cgttcgactg gcactcgtgc gtgcaccaga
    18361 cgtggctcgc cgtgcgcctg ctgcggctac gcccctccct cacgggagcg gacacggccc
    18421 gcaacgccct cgacaagctg gtcacgccgg acaactgcgc cgtcgaggcg gcgttcttcg
    18481 cctccccggc cggccggtac tgggagcgcc cgtacgggtg ggcgtggctg ctgctgctcg
    18541 acgccgagct gcgcacctcg gacctgccgt ggtcggtcgc tccgatcgcc gaggtcctgc
    18601 gcgaccggtg gctcgagtgg atctcggtcg cgcgcctgcc gatccgcacc ggcacgcacg
    18661 gcaacaccgc gttcgcgacg agcctcgtgt tcgacgccgc cagggcgacc ggcgacaccg
    18721 aactggccac cgcgtgcgct gaggcggcac tgcggtggca cggggacgag gccggctacg
    18781 gcggtttcga gccggacgcc gccgacttcc tgtcgcccgc gctgacgacg gccgacctga
    18841 tgcgccgcgc gctggacccg gccgcgttcg ccgactggtt cgacgccttc ctgccggacc
    18901 tcgaggcgga gcggtggcgc gtgctgcgcg agccgttccc ggtcgacgac cccggcgacc
    18961 cctacggctc gcacctggcc gggctcgcgt tgtcgcgcgc ctggaactgg gaggcggtcg
    19021 cggacgcgct gccggacggg caccggtacg cgtcgctggc gcggacggcc tcggcggcgc
    19081 accgcgaggc agggtggagc tacgtgttcg gcgggcacgg ctacatggcc gaccactggc
    19141 tcgggacgtt cggcgcctac ctcgacgtga aggccttctg accacctgcg cgacgttcgc
    19201 gccagctgat atatcggata tcagtggccg gaggtcaggc tcgcgcggcg gacgagggtg
    19261 agcgcgatgc ccgtcgccgc cgcgtgcacc gacgccgcgt gcgtgcgcgg gtcgaaccgc
    19321 gtggtgggtc ccgcgacgct gaccgccgcc accgcggtgc cgtcgtcgcc cagcaccggt
    19381 gacgccacgc aggccagacc gaccctcgac tcctcgaact cgtaggcgac gcccgtctgc
    19441 cggatcttgg tcagctgctg gcggagcatc ccgggcgtga cggcggtgcg cggggtgagg
    19501 cgggccagcg gggaacccag cacctcaccc cgcagccccg tgggcgcgtg ggcgagcagg
    19561 gccttgccga tcgcggtggc gtgcaggggc atgcgtccgc cgaggcgcga cggcgaggac
    19621 gcctggcggt gaccgccgat cttggcggcg taaacgacct cgtggccttc gagcagtccc
    19681 aggtggacgg tctcgtgggt gcgttcgtag aggtcttcga ggtacggcgt ggagacctcg
    19741 accaggcggc gttccaccga cgcgcggatg cccagctgga acaggtggct gcccaggcgg
    19801 tacccgcgcc ggccgcggtc gaggaggcgg acctcggcca actcgcccag caggcggtgc
    19861 agcgtggcct tggagaggcc ggtgcgcctg cccagttcgg cgaagccgag ctcgtcgtcg
    19921 tcggcgccga acgcgttcag caccgacatc accttgccca gcagggtgtt cgggacgtcc
    19981 gtcaccaccc gatcgtgcca ttcggttccg ctcagcggaa ctcgaaggtc ccctccggac
    20041 cgggagcacc gccacgatgt gccgtatgaa cgaagtccag actgcggcgg agcgcctggc
    20101 cacggccgcg cgagacagga tcacgtgtgc gccggtgcgg gacgtcatcg gtgacgccga
    20161 ggcgtacgcg gtgcagcagc acaacatcgc ggcacgcgtc gccgcgggcg cgaaaccggt
    20221 cggccgcaag atcggcctga ccgcgcccgc ggtgcgcagg cagctcggcg ttgaccagcc
    20281 tgacttcggg gtgctgctcg acgacatggc gttcaaggac ggcgacgtgg tcccgaccga
    20341 acgcctgctg cagccgaagg tcgaggccga ggtggcgttc gtgctgaagg ccgacctggc
    20401 cgaaggcccg ttcgacgagc agacggtcgc ggcggcggtc gcgtacgcgc aggcgtcgct
    20461 ggagatcgtc gacagccgga tcgagaactg gaacatcacg ttcgccgaca ccgtcgcgga
    20521 caacgcctcc tctgctctct acgtgctcgg caccgagcag aaggagctgt cggaggtcac
    20581 gccgcgcgac gtgtccgcgg tgctgtcggt caacggcgag gagcgctcga ccggcgccgg
    20641 cgccgactgc atgggcgatc cgctgaccgc cctcgcctgg ctcgccgaga ccgccgtgcg
    20701 gctgggcgac ccgctcaggg ccggtgacgt cgtgctcagc ggcgcgctcg gtcccatggt
    20761 gcccgtgcag gcgggcgacg aggtcgaggc gaccatcacc ggcctcggca cggtccgggc
    20821 cacgttcgct cccgaggagg cgtaagtgaa ggtcgcgatc atcgggtcgg gcaacatcgg
    20881 caccgacctc gtcatcaagg tgctcaagcg gtcgtccgtg ctggaggtgg cggcgctggt
    20941 cggcatcgac cccgagtcgg acggcctcgc caaggcgcgc gggctcgggg tcgcgacgac
    21001 ctcggacggc atcgaggggc tcgtcgccct gccggggttc gacgagatcg agatcgtgtt
    21061 cgacgcgacc tcggcgggcg cccacgccaa gcacgcggag gtcctcgcgg cacacggcaa
    21121 gaaggtcatc gacctcacgc cggccgcgat cgggccgatg gtggtgccga cggtcaacct
    21181 cgacgagcac ctcgacgccc cgaacgtcaa catggtcacc tgcggcggtc aggccacgat
    21241 cccggtcgtc gccgcgatca actccgtcac gcccgtgccg tacgcggaga tcgtcgcctc
    21301 gatctcgtcg cgcagcgcgg ggcccggcac cagggcgaac atcgacgagt tcaccgagac
    21361 gacggcgcag gccatcgcgg acgtcggtgg cgcgaagcgg ggcaaggccg tcatcgtgct
    21421 caaccccgcc gacccgccga tcaccatgcg cgacacggtc ctcgcgctcg tgcacgcacc
    21481 ggaccccgag acgcacgagg agatccgcga gtccgtcgag cggatgatct cccgggtcgc
    21541 cgcgtacgtc cccggctacc ggctgaagca gaacgtgcag atcgacccgg tcgaccagcc
    21601 ggccaccctc accgaggagc cggtgacgca ccaggtcacg gtgctgctgg aggtcgaggg
    21661 cgcggccgac tacctgcccg cctacgccgg caacctcgac atcatgacca gcgcggccgt
    21721 ccgggtcgcc gagaccatgg cgaaggcggt ggtgcgcgca tgaagctcta catccaggac
    21781 gtgacgctcc gggacggcat gcacgccctg cggcaccgca tcgacccgaa gaaggtcgcc
    21841 gagatcgcga aggcgctgga cgacgcgggt gtcgacgccg tcgaggtgtc gcacggcgac
    21901 ggcctgagcg gcggttcgct cgtctacggc cccggcagcc acaccgactg ggagtggatc
    21961 gaggccgccg ccggggcgtt gaccggggcg aagctcacga cgctgctgct gccgggcatc
    22021 ggcacgctgc acgacctcaa gcgcgcccac ggcctcggcg tgcagtcggt ccgcatcgcc
    22081 acgcactgca ccgaggccga catctcggcg cagcacatcg ccggcgcgcg cgacctcggc
    22141 atggacgtgt ccgggttcct gatgatgagc cacctcgccg aacctcagga gctcgcgcgg
    22201 caggcgaagc tgatggagtc ctacggcgcg aactgcgtct acgtgacgga ctccggcggc
    22261 cgcctgctgc cgaaggacgt ccgcgaccgc atccgcgcgt acaaggacgt tctcgacgag
    22321 cggaccgaaa taggcattca cgcccatgag aacctctcac tggcggtcgc gaactccatc
    22381 gccgccgtcg aggagggtgc gaccagggtc gacgcctccc tggccggact gggtgccggt
    22441 gcgggcaact gcccgatcga gccgttcgtg gccgtcgcga acctccagga gtggcagcac
    22501 aacgccgacc tgttcgcgct gcaagacgcc gccgacgacc tggtccgccc gctgatggac
    22561 cgcccggtcc gcgtcgaccg cgagagcctc accctgggct acgcgggcgt ctacggctcg
    22621 ttcctgcgcc acgccgacac ggccgcccgg cgcaccggcg ccgacgtccg cacgctcctg
    22681 ctggaggcgg gacgccggcg cctggtgggc ggtcaggagg acatgctcac cgacatcgcc
    22741 ctggacctca cgcggtagac ggcttcacac agcactgctc atacggggaa cgtggttccg
    22801 atgcccatgc ccgtgatcca ctcgggcacg ggctcgtaac tcgtccacac gagcggcagg
    22861 ccgacggcga cctgcccgat gagccagcag cggatctcgt gcccgccgct gccggcgtgg
    22921 tcctcgagcg cctcgtgccc gagggaggcc acctcgcccg cctcccccgc caccagccgg
    22981 tcgaggaacc actcgtccca cgcggcgttc acgcgggcgt ccgggttgcc tcccatggcc
    23041 ttcacccgcg gctcccgcgc ggcggcgaac tcgtggacgt aggcccgtcc ccggatcagc
    23101 gactcgcgcc gctcccccac cacggagggg tcgcgcgggt cgttggacgg taaccagtgc
    23161 gacagcccgc cggacgcgac caccagcacc cgtccgggga actccgagga ccgcagcgcc
    23221 gcccccagcg cccggcccat cccgacgcac cggtcgagcg acggcagcgg cggcgccgcc
    23281 gtgttgacca ccagcggcac caacggcagc gtcgtgccgc cggtgatcat ctcgtagctc
    23341 tgcacgatgc cgtggtcgac ggtcagcgag tacgacagcg acacgtcgaa ccccgctccg
    23401 gccagcccgc cgtgggccga ccacgccagc gtccgctcca ccggcaacgg gcccgagctg
    23461 ctgccgaagt cgccgaaccc caccgcctcc tcgacgccga gcacgaacgg cggcatcacg
    23521 tcgtagaagt tggcgtggaa gtggtcgggc ccgatcacga cgatcgcgtc cggcgccagc
    23581 tcgtccacgg ccttgcgcac ccggtcggcg tcccgcagga acaccgagcc gggcccggcg
    23641 ccgtccggtg gcagcagcgt cgcgaacggg ctgtgcgaca tcccggcgaa accgatgatc
    23701 tcggccatca ggacgggtcc tttccgtgca gcaaccacgt gcggtgcgtg tcgaggaact
    23761 cggagacctt ctcccactgc ggccagtgcc cggcgtcgtc gatgacgtgc agccgcgcgt
    23821 ccggcagcca cctcagcagc aggtcggcct cgtccagccc gcccgtcggg tcgtggctgg
    23881 tccacagcag caacgtcggc gccgcgacct cgccg
//
