LOCUS       NZ_CP099738            25983 bp    DNA     circular CON 27-AUG-2024
DEFINITION  Lentzea sp. HUAS12 chromosome.
ACCESSION   NZ_CP099738
VERSION     NZ_CP099738.1
KEYWORDS    RefSeq.
SOURCE      Lentzea sp. HUAS12
  ORGANISM  Lentzea sp. HUAS12
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Lentzea.
REFERENCE   1  (bases 1 to 9676923)
  AUTHORS   Ping,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-JUN-2022) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024125735.1-RS_2024_08_27
            Annotation Date                   :: 08/27/2024 06:34:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,161
            CDSs (total)                      :: 9,080
            Genes (coding)                    :: 8,988
            CDSs (with protein)               :: 8,988
            Genes (RNA)                       :: 81
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 92
            CDSs (without protein)            :: 92
            Pseudo Genes (ambiguous residues) :: 0 of 92
            Pseudo Genes (frameshifted)       :: 21 of 92
            Pseudo Genes (incomplete)         :: 77 of 92
            Pseudo Genes (internal stop)      :: 3 of 92
            Pseudo Genes (multiple problems)  :: 8 of 92
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:47:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4615928
            Orig. end                         :: 4641911
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP099738.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Ping Mo.
FEATURES             Location/Qualifiers
     region          1..25983
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="23"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..25983
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25983
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15983](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15983
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            complement(418..744)
                     /locus_tag="ND450_RS20245"
                     /old_locus_tag="ND450_20245"
     CDS             complement(418..744)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS20245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_20245"
                     /product="hypothetical protein"
                     /protein_id="WP_253327631.1"
                     /transl_table=11
                     /translation="MAAHGGGDVLGLAASVAFAVELVFEFADAVFEPGDAVAQGGELGG
                     VRGFAGGKCGELVGAVRPVGGHEPVVGGEQVVHDDHERSGNAKLGRQGGVHVPPSEVQG
                     DSLW"
     misc_feature    complement(574..576)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    772..787
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     gene            1143..1787
                     /locus_tag="ND450_RS20250"
                     /old_locus_tag="ND450_20250"
     CDS             1143..1787
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009950979.1"
                     /locus_tag="ND450_RS20250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_20250"
                     /product="adenosylcobinamide amidohydrolase"
                     /protein_id="WP_256557560.1"
                     /transl_table=11
                     /translation="MIVEVHELDRAVLLWRVPRGTRAVSTAVVGGGIGSCNWVVNAEVD
                     HDYHRDPVEHLLEITAQLRLSGRGAGMVTAAEVKRYASATADRGVHCATTVGLSYPVFA
                     SAPHDEVPRSVGTINTFCWVPVPLEDGALVNMVVTATEAKSQALTELDIPGTGTASDAV
                     VICCPEGPGEQFGGPRSVWGAELARAVHTATLMGARDWLSRNELKGLWFQG"
     gene            complement(1887..2702)
                     /locus_tag="ND450_RS20255"
                     /old_locus_tag="ND450_20255"
     CDS             complement(1887..2702)
                     /NRPS_PKS="Domain: Abhydrolase_1 (10-249). E-value:
                     1.7e-27. Score: 88.6. Matches aSDomain:
                     nrpspksdomains_ND450_RS20255_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.5"
                     /locus_tag="ND450_RS20255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_20255"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_253327633.1"
                     /sec_met_domain="PF00561 (E-value: 1.5e-19, bitscore: 69.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.2e-21, bitscore:
                     76.5, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTAAAHEPRTIVLLHGFPQSSLCWNDVQRSLRAAGHHTVAPDLR
                     GYTPHDRPAEQEAYRSEAIADCLISTLEHLGTPVDLVGHDWGGGVAWHIALRRPDLLRS
                     LTAVSTPHPAAYTRALREDPEQRRKSEYIKFFTSADATDQLLADNAAGLRAVFSHSRMS
                     AELISSYVGPLSTPAALNAALAWYHAVDGAGSQPPGRCIVPTCYLWGDSDEAFSHAAAE
                     GTAALVEGPYTFRVLRGGSHWLPDENPDEVASAVLELIASTTARPSGGE"
     aSDomain        complement(1956..2672)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ND450_RS20255_Abhydrolase_1.1"
                     /evalue="1.70E-27"
                     /label="ND450_RS20255_Abhydrolase_1.1"
                     /locus_tag="ND450_RS20255"
                     /protein_end="249"
                     /protein_start="10"
                     /score="88.6"
                     /tool="antismash"
                     /translation="TIVLLHGFPQSSLCWNDVQRSLRAAGHHTVAPDLRGYTPHDRPAE
                     QEAYRSEAIADCLISTLEHLGTPVDLVGHDWGGGVAWHIALRRPDLLRSLTAVSTPHPA
                     AYTRALREDPEQRRKSEYIKFFTSADATDQLLADNAAGLRAVFSHSRMSAELISSYVGP
                     LSTPAALNAALAWYHAVDGAGSQPPGRCIVPTCYLWGDSDEAFSHAAAEGTAALVEGPY
                     TFRVLRGGSHWLPDENP"
     gene            complement(2699..3985)
                     /locus_tag="ND450_RS20260"
                     /old_locus_tag="ND450_20260"
     CDS             complement(2699..3985)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1246: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS20260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_20260"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_253327634.1"
                     /transl_table=11
                     /translation="MSGSKRAVVIGASMAGVLAASALQSVYDEVVIVERDSIAGRPSSR
                     RGVGQSKHAHGLLARGSQAIEELVPGITAELLAGGARSYDVLQQGNFYNHGQLMAHGVS
                     DLRGLMVSRNLLEHTVRQSVLRMPAVRMVDGREVLGLLHETGVVLGVTCSGPDGVDTIE
                     ADLVVDTTGRVSKLASWLVAMGFQAPAEERVDVDLVYTTWTVTVPDHIAARHGGALVGP
                     TPGNPRAAALLWIEGNRWTATLAGYQGLRAPLSVEGFLEFAADLPTRHLHEVLSHAKFE
                     EGPHVYRVPANRRLRYDRLSRFPAGLLALGDSMCVFNPLYGQGMTVSALQALLLRACLT
                     EGEEALARRFFAGAAEIIDVAWRIATDADSVVVGTANPEQLSASEQMGHFHEAAAHDPE
                     LARQFLQVINFLEPSSSLVEALRNRGGAA"
     misc_feature    4055..4066
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            4154..4387
                     /locus_tag="ND450_RS20265"
                     /old_locus_tag="ND450_20265"
     CDS             4154..4387
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS20265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_20265"
                     /product="hypothetical protein"
                     /protein_id="WP_253327635.1"
                     /transl_table=11
                     /translation="MHFAKISAAALAIGAILLSDGQALASTTAASQASGTLVIAEYKTQ
                     RECVNESLYTPKSYCRPSGRGTYYLLVPVIEA"
     gene            4964..6160
                     /locus_tag="ND450_RS20270"
                     /old_locus_tag="ND450_20270"
     CDS             4964..6160
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.5"
                     /locus_tag="ND450_RS20270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_20270"
                     /product="cytochrome P450"
                     /protein_id="WP_253327636.1"
                     /sec_met_domain="p450 (E-value: 2.4e-18, bitscore: 65.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPHVSYPLQDVPGIDISPVVRDLIDRGPVHPVDTAGGRIGWLVT
                     GHDAVQEVLRDPQFSRAAMTGDAADPLGGAFEGPGAIVSLDPPDHTRVRKVIAASFTPR
                     TITRLRPGVEVIAEQLVTAMIASGSPGDLVAGVGVPLPLMVICELLGVPYEDRATFSRW
                     ADSIMAISSISPDEASANKQSLLGYLHDLVRARRNEAQHDLVSLLAHTPTGDGTPLDGL
                     EIANLCIGILVGGYDTTANEICNMVFLLCTNPHLMAHARTGSTGLNETIDEMMRWIALS
                     INVGFPRKATRDTVLGGQPIAAGDVVFPDVIAANRDASVFADPHSLVPGRENQRRTLLF
                     GSGPHFCPGAHLARTEIEVALSTLLRRLPGLRLAVAPEEVPWRWGQLVRGPRELLISW"
     gene            complement(6263..7174)
                     /locus_tag="ND450_RS20275"
                     /old_locus_tag="ND450_20275"
     CDS             complement(6263..7174)
                     /NRPS_PKS="Domain: Abhydrolase_1 (47-170). E-value:
                     1.3e-21. Score: 69.3. Matches aSDomain:
                     nrpspksdomains_ND450_RS20275_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.5"
                     /locus_tag="ND450_RS20275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_20275"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_256557539.1"
                     /sec_met_domain="PF00561 (E-value: 5.1e-17, bitscore: 61.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.9e-10, bitscore:
                     40.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYHLISADVRGRGNCRIGLAKASGKLLSSPGSSHRVFVCADGPDS
                     APNVTLIHGFPISSHDWAPMRPALRQRDLRLVAPDLLGFGHSDKPLQHCYRIHDQAEMI
                     MAVWDHFGIASTDLVAHDYGVSVARELLARCPERITSVAWLNGGLCPDLHRPVLAQRLL
                     HSGLGPRVARAMSYRSFVRSLRSVLGRPVSEEVLAEMWCSVTHARGNRVVPALMRYIHD
                     RRLHQRRWTEALENFAGPMSFFWGPADPISGAHVLNRIRERMPAAQVFELSDPVVGHYP
                     QVEDPERVGALVADFLTASARF"
     aSDomain        complement(6665..7033)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ND450_RS20275_Abhydrolase_1.1"
                     /evalue="1.30E-21"
                     /label="ND450_RS20275_Abhydrolase_1.1"
                     /locus_tag="ND450_RS20275"
                     /protein_end="170"
                     /protein_start="47"
                     /score="69.3"
                     /tool="antismash"
                     /translation="NVTLIHGFPISSHDWAPMRPALRQRDLRLVAPDLLGFGHSDKPLQ
                     HCYRIHDQAEMIMAVWDHFGIASTDLVAHDYGVSVARELLARCPERITSVAWLNGGLCP
                     DLHRPVLAQRLLHSGLGPR"
     misc_feature    complement(7165..7180)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.89"
                     /tool="antismash"
     gene            7205..7624
                     /locus_tag="ND450_RS20280"
                     /old_locus_tag="ND450_20280"
     CDS             7205..7624
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS20280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_20280"
                     /product="hypothetical protein"
                     /protein_id="WP_253327638.1"
                     /transl_table=11
                     /translation="MRTTLQIAILRLIQDGEKMGFSRILTASTVAFAALLGALPGVASA
                     DVVVPPRGQYIFARFPGESGLTFRITCRTATAGATAAADIGWRYGENDWRATSYGVATP
                     FTSTYSRPNTSTKITFVANNLSYDRSLSCNGTIVS"
     misc_feature    complement(7228..7243)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.96"
                     /tool="antismash"
     gene            7626..8117
                     /locus_tag="ND450_RS20285"
                     /old_locus_tag="ND450_20285"
     CDS             7626..8117
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS20285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_20285"
                     /product="hypothetical protein"
                     /protein_id="WP_253327639.1"
                     /transl_table=11
                     /translation="MSKHTTRPAENSRLVHHSASQKFRKAYPMPSTTKARGAVSRLRLL
                     SAAFAVMTTVMTVSSMPATADVSALDAMTLQPGAQGGLVVPGNEQKLSFYVECETNPAG
                     QAARANVAWYQNGRLVANTAGRATPFRSSWSRPTSSVRLEFRATNAAGTVPIRCALYSA
                     "
     gene            8222..8386
                     /locus_tag="ND450_RS20290"
                     /old_locus_tag="ND450_20290"
     CDS             8222..8386
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS20290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_20290"
                     /product="hypothetical protein"
                     /protein_id="WP_253327640.1"
                     /transl_table=11
                     /translation="MFDELDTFDMAALEIMPISNDSVEAALAAGHGATEIGLSTSFCSV
                     GCSFAGPVA"
     gene            8443..9819
                     /locus_tag="ND450_RS20295"
                     /old_locus_tag="ND450_20295"
     CDS             8443..9819
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS20295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_20295"
                     /product="hypothetical protein"
                     /protein_id="WP_253327641.1"
                     /transl_table=11
                     /translation="MRAVLRRGVWIESRGSEIVLPGPDGELRFSGAAGRFMSLLCERLD
                     GSMSVAELRAAAPAHLVERLDEALTLLRSNGLLSCGEPPDVPLIVLGGPAYWRDRAKRS
                     LVTGASSSRSTVTESAVHAVLRGDTAWIGPLGCTETRWSQIECRLPPFTGFSHDFAPPE
                     LVAAVLELEVKTRRRGTCPQVVAVHPDGTTSRHNVVPVRSMREDLSREQALRWCTDPVT
                     GVLRGVGETGLFQGFGVATKATAAASGPASAAVLTAVAVADDLATARARACERVLRKHI
                     TSDLLLRRTANTVIGVGSDMSEAAAECLSQVSGGPRLSVPAERVRAIVATAPSPLRDFE
                     QLLDADDRSWAVTQLGDEVPVLEFWLDNRVVGRFCTPTPERTVERGVESLLSAAAAGVQ
                     RERGRTVIGSAGVAPSWRTCGDPLTVLGNRMNPVESRDEAGSPVWRAAGVSCQVEVCVG
                     "
     misc_feature    9825..9840
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.51"
                     /tool="antismash"
     gene            10001..11656
                     /locus_tag="ND450_RS20300"
                     /old_locus_tag="ND450_20300"
     CDS             10001..11656
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03604.1"
                     /locus_tag="ND450_RS20300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_20300"
                     /product="YcaO-like family protein"
                     /protein_id="WP_253327642.1"
                     /sec_met_domain="YcaO (E-value: 9.9e-64, bitscore: 215.2,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 3.3e-80, bitscore:
                     268.8, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAVFDGGSVIICAGQGVAGSCARCAVRRRKALHSGRRDVGDQTA
                     HTAAEDRLVAAVLSAVLERGLPDDTLVRQVRPAVPAVTDHRLIRDPGCEVCGEDGEPSY
                     DPVPRTPRPVLQGRFRLTDLRGAGAVPLLRCSDEEFGVTSNLVRHHPTTFPSVSASVPL
                     GLDGAADRGYGRALDSCDAEVVAVAEALERRAARHHRDAAAVASSAQLGDRAFDVSSLG
                     LPVGPQGFPYQRLTPDVELAWVTAWSAGQDRLVLVPRSVAYYQSWATGADQPVLQETSS
                     GCAVGSCLEEAVLHALVEVVERDAVITAWYARTPLPEVDLTTVTDPELRVLITRMRTRS
                     GYDLRAFWATRDIAVPVFWVVATAPPGQPDLPAIVCASGAAPCPAGALRGGLLELAAAL
                     DHRRASWPGDPEQRHRAARMLQDPGLVQDITDHGLLYCHPDTVPRWNFLLGHGAMRPWR
                     EFAKSRRPSRGDLLLDCRALVQETLARCADVLVVDQTTVEHTTAELRCVKVLVPGAVPI
                     TFGHNARRVLGIPRLDAALTASARALTSHPHPFQ"
     misc_feature    10946..10948
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11906..14161
                     /locus_tag="ND450_RS20305"
                     /old_locus_tag="ND450_20305"
     CDS             11906..14161
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS20305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_20305"
                     /product="lantibiotic dehydratase family protein"
                     /protein_id="WP_253327643.1"
                     /transl_table=11
                     /translation="MRAADVHIARTWSGDRIGDAVAEVAARSAEIDRLGAELEVIVTEH
                     ERSALDHLRRVCADPVVQRGLRSTLPAVADAILPWLRGGTPPGWRLRAALVRLVCRAAV
                     KTSPLSSFLVQGAARWHDELADSGNRTALVVEPSVERLMRLRAVIAREPRLWPRLSIRL
                     NPGLVAHTDRLVVLGPPPSGDVAEIPLTPALERALALIADRTPATTQDVASALSRRPDQ
                     GELLVRRLVEANVLEVHVPVADQDPEWPRTLLAWLRERSTDAELVAALEELAAAPATER
                     LDECGRAVERGVHRVDRWLADQAAPRGTGAWATEEMVVSEAIAVPRAPAFHVRDDLGRL
                     RQVLSPFDSTLPYRAALAGFHASAFTRSPVPFLVLYQELHRALRDPGHRHHIAARAVQD
                     AAVWPGNAPPGPEWNLLRDVLAARSAAERTLRSLPCDEEEVEVPDLEPIALGGRWSLPR
                     IAVLGQPLPEGRFAVNSVVPAQAWGASHVDRALRRAGFAGLRAEPPSDGGAALRIEVEN
                     VLGHPLNARTRTTTHVLDYPSLVSSAARDRRVPIGELIVVSDQSGLLQLRWSREDVAVE
                     PVHTSTLSPAFLPPALHLLVHGFCADTLTLYPGRLWLRRPSADDRSDVVSHPRLVLGRL
                     VLRRRSWSAWVDGLPRRAAGETGAHHLVRWARWLAEHGVPERCFVRAYQHDSTAASTNT
                     TKARKPLYFDLGSPLLVRAVEDSLRGAGGIAVFTELAPDPGSADRVEEHVLLEGEVR"
     gene            14158..14913
                     /locus_tag="ND450_RS20310"
                     /old_locus_tag="ND450_20310"
     CDS             14158..14913
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF025394.5"
                     /locus_tag="ND450_RS20310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_20310"
                     /product="lantibiotic dehydratase C-terminal
                     domain-containing protein"
                     /protein_id="WP_253327644.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.5e-38, bitscore:
                     131.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDTSWVCLHVHLSHRQDDYLRDVVRPLFQSMMDGELVDRCFFLR
                     YWQEGPHIRVRLHPRISADRARIRHALLENSSDWLREGPAAPEIDERSWLDAVRPWAAA
                     EGERDVLPPLPHGSLVESTYRPEHDRYGRGAVLEAVERHFTDSSRLALRHLEHDMPTRA
                     RLTLTATWLAESHAEGLVSDNPALAGSPLAHSVAELVHALRTADDAPPISRVVRDCAHL
                     LANRLGIGPLQEDALRALVLATRADRAFA"
     gene            14910..15983
                     /locus_tag="ND450_RS20315"
                     /old_locus_tag="ND450_20315"
     CDS             14910..15983
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF025394.5"
                     /locus_tag="ND450_RS20315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_20315"
                     /product="lantibiotic dehydratase C-terminal
                     domain-containing protein"
                     /protein_id="WP_253327645.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.2e-28, bitscore:
                     99.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVGQWAAARVHYYSQDRDALVLRAVAPLLRWLEDRSVPSYFAPH
                     WRLGPHLRIAVAPRTGSEDLLAHGVQTFVEPFLLNEPSTARIDPDALRTVHEQLAWDEQ
                     VLEPLHPLAPDNSVHFGVEDDRSGVVGTEFAGLVRDFDVAAWKHSVDSYRLVEAGRSKF
                     SLAFDLLASTALIATPERHDPVSGFGSMRMQAERLVVTASDPVRVRQHCESLYDRLRPA
                     LIRRLRSIVDGVPDGDIAGLRWTSLIEPRRDEATALHRRGVRMPMASADPATWGRYAES
                     VRASPLHMATMGDPAQLERLSRCDWHQGYRFAVNLCYLQLTRLGITASQRLQVCYLLSR
                     TATDVIGTLTSPDRVGA"
     gene            15985..16935
                     /locus_tag="ND450_RS20320"
                     /old_locus_tag="ND450_20320"
     CDS             15985..16935
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019619.5"
                     /locus_tag="ND450_RS20320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_20320"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_253327646.1"
                     /transl_table=11
                     /translation="MHPLVERFAALARLSQVQEQPSPAHLPGLGKCAPFTAVTAAEVEG
                     VIGRHGLRSEQVVVTRHGVVVPAAQYTATARIDRVPLPGVVRHAALFDLVESGHTLALP
                     GCELWLPGIAVLCDQLRSALAQPVLAGLFLTPASETGLSVHTDAYDVLAVQTTGSKRWR
                     VFAKRPEPVRNAPVDVSDEPVLDVVLQQGDALFVPRGCPHVASAESFSLHVSLGVQAMT
                     AREVLVAAMRSATLSADLDAPMPYREVGDLNDRRAAVLRRASEALLTGLSSDQADRVYQ
                     ALSSSTTTAPSPGRLRRLESAAEMTDSPSWPGTAP"
     gene            complement(17108..17668)
                     /locus_tag="ND450_RS20325"
                     /old_locus_tag="ND450_20325"
     CDS             complement(17108..17668)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012447.5"
                     /locus_tag="ND450_RS20325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_20325"
                     /product="aromatic amino acid lyase"
                     /protein_id="WP_253327647.1"
                     /transl_table=11
                     /translation="MFRADNLVADDSDSSASREMCGEDVGVKLGDDSLSVDQVVAVARA
                     GEDLSVRIDGRAAARMRRSVELRHRLIATGRPIYGVITGFGDSARFHLSPDKATAFQQN
                     LVTYHLNGTGSSAPVEVVRAAMLIRANSLSRGFSEQAERVAQGLEPIDVILHFDPHAVL
                     ELPQERKKFGDGSAFIADLMSAT"
     misc_feature    complement(17725..17739)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.79"
                     /tool="antismash"
     gene            18354..18671
                     /locus_tag="ND450_RS20330"
                     /old_locus_tag="ND450_20330"
     CDS             18354..18671
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS20330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_20330"
                     /product="hypothetical protein"
                     /protein_id="WP_253327648.1"
                     /transl_table=11
                     /translation="MKYISPAKMALLGACAVTAMLSAAGQASAASANDCSQTQSSPGSI
                     TLACSGVGSSIGAAEAEAERSLTLWWNRDGRRHSCAGVSEQQYIITNGYKVVANYRCSV
                     A"
     misc_feature    19185..19198
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.65"
                     /tool="antismash"
     gene            20076..21530
                     /locus_tag="ND450_RS20335"
                     /old_locus_tag="ND450_20335"
     CDS             20076..21530
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012376.5"
                     /locus_tag="ND450_RS20335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_20335"
                     /product="metallophosphoesterase"
                     /protein_id="WP_253327649.1"
                     /transl_table=11
                     /translation="MREDAESNSSSGSKPSTVVERHVYRHVAVAEGLTSRRVPYRVVSF
                     DERWRVAITPVHTLSAVARAGEPVTLLLTSDHQLKTMTPANLELVGQTVGTELDGVLMA
                     GDLVNVPDRASEWFDDASGLAFFAGMTGRAHREIAGRIYRGAPLLQNSPLYPVIGNHEV
                     MGRYSTTNPLSAQFNDPQPRRIAMRDRTARGSVDDRSWNVRTYEELFPYPRSNSGGSRW
                     WSRTVGDVFLVGLFVTQIWRVPTAGARGRYSEAESDLRSPERWGYGQFPFESVAKGSEQ
                     YRWAQRELSSPEARRAKYRVVMFHHPSHGLGDNSAPPFSDPEQSVERDPATGEVSAVRY
                     HYSLQRDEILTDLEPMLNSHGVHLVLNGHSHIWNRFRNARGMHWLETSNVGNTYGAYDT
                     SSGASRAVPQSPDYVQQGDPGGLRPVVPTIAPLTGPDGTPLPFVSSNSVTAFSVLDSGR
                     GVVRSYRYDTRTPKDAAVLFDEFSLL"
     gene            complement(21689..22252)
                     /locus_tag="ND450_RS20340"
                     /old_locus_tag="ND450_20340"
     CDS             complement(21689..22252)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS20340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_20340"
                     /product="hypothetical protein"
                     /protein_id="WP_253327650.1"
                     /transl_table=11
                     /translation="MTVASLQRFSNPTAKKEKMSKSLKLPRLARAASVALAASAVLISP
                     LAAGQASAVNGYFQVSIQCPVLASESYSPTPGSITYHEYRLTPSISVTATGAAGSGSAS
                     GACPSSGASQRIYINVVVPKGANYTLDANVSGLGKFQNPRAPYPIPATITITSFAATPG
                     GSGTGTSRTVRDGANALGSGFNIG"
     gene            complement(22249..22629)
                     /locus_tag="ND450_RS20345"
                     /old_locus_tag="ND450_20345"
     CDS             complement(22249..22629)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS20345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_20345"
                     /product="hypothetical protein"
                     /protein_id="WP_253327651.1"
                     /transl_table=11
                     /translation="MNTSLRQKGSVAFVLLAIVASLFGTAGTSVAEGYPTTPSGSVFFA
                     VKPGKTSATITVDFTVSPRLYKAEILVNGGVKSIITGACEAPAPFCNYSRTVATFSSVP
                     IDSLEFRLYATNGTISNSRIVQ"
     misc_feature    complement(23019..23035)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.03"
                     /tool="antismash"
     gene            23028..24929
                     /locus_tag="ND450_RS20350"
                     /old_locus_tag="ND450_20350"
     CDS             23028..24929
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00229.1"
                     /locus_tag="ND450_RS20350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_20350"
                     /product="PAS domain-containing protein"
                     /protein_id="WP_253327652.1"
                     /transl_table=11
                     /translation="MVRFGRTTRIGTAERLDHRMSGGDFAHSGDTREQAELDAGNDLRV
                     STWWGGEWARALNAISFAVKDHDRRFVHVSPGFADRLGTSPQQLIGLSDADLPGMAEAD
                     RYRIRAEEDTVISGNLPLAITVRFRQRDGWTGHGVGIRFPVAGPDGRPGVGSLLLDITE
                     HVRAKERFALFMQHSGAFGAIKDLNQHYIWVTDTVAKHHGRHVDEVVGRTPAEVCDPEV
                     AELELAQDTAMLEAGGGPMTFELRDRGAGDAPLVRRGTRFTFTDADGRTCIGSVFIDVT
                     AEVEASARAAAAEERFTSFMRHNPAAAVMKDAEGRYLWANPAYFHTYRVDPDHFVGRTI
                     HDLTDTETAAYATALDQQVMSSGQPLRDTSRHTRGDGSTGVDIGYRFPLPAPDGRTGLG
                     AVSIDITELHEAREAAMRAEARYRELFEHSGIPIIVFDLGGKVVNANIAYAQMIGHSLS
                     HLRSLHIRDLVTGTTAVKDKPRWDKLVSGEIGRYRSRAMLRHAKGTLSAAVATMSLISS
                     PDGTPQYVYSVTDPVADIDTDLAPRAATGPVPQLEEERLCREEHTILTTLAAGGTLAEA
                     GTALHLSRQGVNHHVTKLRRRLGLPERTRTAGLVARAYAVGILVPGTWPPHTAAPYS"
     misc_feature    25682..25691
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     misc_feature    complement(25798..25818)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.75"
                     /tool="antismash"
ORIGIN
        1 cgcaatccat acaaaggcac cgaggacgat caggcagatt gcggcgatca ccatagcgtt
       61 catgggtact ccagcacaac ggctggtgtt ggaaggcgat tagcaaacca acacgcaagg
      121 gaaccaacag gactaagcga tcgcgcctgt ggaaggacac accgacgaat tggtgttgcg
      181 atcactctca ggagcgccct atgtgggcac gtccatctga ggccgactac ctcttagatg
      241 aggcggactg gcagacctcg tcctagcgga tcactctccc ttgcggctgc aagcttgcag
      301 cttggtaacg accaacgggt ctcgccaaat acttggccca cgaccgacag gtcaagtctg
      361 cacgagagta cacgccacag agccatatgc ttgtcgcacg agctgcggat tcatgcctca
      421 ccagagcgaa tctccctgta cctcggaagg aggaacgtgg acccctcctt gccgccccaa
      481 cttggcgttg ccggagcgct cgtgatcgtc gtggactacc tgctcaccgc caaccacagg
      541 ctcatgaccg ccaaccggtc tgaccgcgcc gactaactcg ccgcacttac cgcccgcgaa
      601 accgcgcacg ccaccgagct caccgccctg cgcaaccgcg tcgccgggct cgaagactgc
      661 atcagcgaac tcgaagacga gctcgaccgc gaacgcgacc gacgccgcca agccgaggac
      721 atcgccgccg ccgtgcgccg ccacacctaa cccaccccta aacgaacggc cgtcacctgc
      781 tggtcaccta ctcgtgcagc agacccgttt taccggtttc gcgcccgtat ccatgaacca
      841 caggaaacat gtctgagtag cagcagtttg acgccttgcg gggcgtcggg cgctagccac
      901 aggcttggcg tcggaggctc gcccgcgcct tgtacttgcg actccatcat tcgaccagcc
      961 acgacacctt gcgtgacccg aatcacttca gagtgtcgcc ttcggttcta tttaagcgct
     1021 acctgattcg tcccgcaaac gccgcaacct tggcatacat gtacggttcg ggcctgtgtg
     1081 gaccgttccc ggcgtgttcc tgccgcaccc gtccgattac gcagaagctc aggcggttcc
     1141 gggtgattgt tgaagtacat gaattggatc gcgccgtcct gctgtggcgg gttccccgag
     1201 ggacacgtgc tgtgtccacc gccgttgtgg gtggcggcat cggaagctgc aactgggttg
     1261 tgaacgccga ggtggaccac gactaccacc gcgatccggt cgagcacctg ctggagatca
     1321 ctgctcagct gagactctcc ggcaggggtg ccggcatggt gaccgccgcg gaagtcaagc
     1381 ggtacgcgtc ggccaccgcc gaccgtggcg tgcactgcgc gacgaccgtc ggcttgtcgt
     1441 accccgtttt cgcctcggct ccgcatgacg aggtaccgcg ttcggtcgga acgatcaaca
     1501 ccttctgctg ggtgcccgtc cctctcgagg acggcgcctt ggtcaacatg gtggtgaccg
     1561 ctaccgaggc caagtcccag gctctgacgg agctcgacat acccggcacc gggacagcga
     1621 gtgacgcggt tgtcatctgc tgcccggaag gtcccggaga gcagttcggc ggccccagat
     1681 cggtctgggg cgccgaactc gcgcgcgccg tgcacaccgc gaccctgatg ggggctagag
     1741 actggttgtc gcgcaacgaa ctgaaaggcc tctggttcca gggctagccg cagaccgctc
     1801 gcagccgtgc tcgaccacga aatacatcga gacatgaacc acatacctcg tggcacaacc
     1861 agaagcgcgg gcctcgctgt ggttcatcac tcgccgccgg acggccgggc ggtggtcgaa
     1921 gcgatgagct cgagaacggc cgatgcgact tcgtcgggat tttcgtccgg aagccagtgg
     1981 cttccgcctc gcaacactcg gaaggtgtaa ggaccttcga cgagtgcggc ggtgccctcc
     2041 gcagcggcgt gggagaaggc ctcgtcgctg tcaccccaca gatagcaggt gggaacgatg
     2101 catcggcccg gcggctggct gcctgcaccg tcaacggcgt ggtaccaggc cagggccgcg
     2161 ttcagcgctg cgggagtgga cagcggcccg acgtaggagc tgatcaactc cgcggacatg
     2221 cgggagtggg agaacaccgc ccgcaggcct gcggcgttgt cggcgagcaa ctgatccgtc
     2281 gcgtcggcgg atgtgaagaa cttgatgtac tccgacttcc gccgctgctc cggatcctcg
     2341 cgcagtgccc gtgtgtaggc agcgggatga ggtgtcgaca ccgcggtgag cgaccgcagc
     2401 aaatcgggcc ttctcagtgc gatgtgccat gcgaccccac cgccccagtc gtggccgacg
     2461 aggtccacag gcgtgccgag gtgttcgagc gtcgagatga gacagtccgc gatcgcctcg
     2521 ctccggtacg cctcctgctc cgcaggacgg tcgtgcgggg tgtagccgcg caggtccggc
     2581 gcgacagtgt ggtggccggc agctctgagt gaacgttgca cgtcgttcca gcacaacgaa
     2641 ctttgcggga atccgtgcag tagcacgatg gtgcgcggtt cgtgcgcggc agcggtgttc
     2701 acgcggcccc tccgcggttg cgcagcgcct cgaccaggct gctggacggt tccaggaagt
     2761 tgatgacctg gaggaactgg cgtgccagtt cgggatcgtg ggccgctgcc tcgtggaagt
     2821 gtcccatctg ctcgctcgcg gacagctgtt ccgggttcgc ggtgcccacc acgacggagt
     2881 cggcgtcggt cgcgatcctc cacgcaacgt cgatgatctc ggcggcgccg gcgaagaagc
     2941 gacgggctag cgcctcttcg ccctcggtga gacaggcacg aaggagcagc gcctgcaggg
     3001 cggacaccgt catgccctgc ccgtaaaggg gattgaacac gcacatgctg tcgccgaggg
     3061 cgagcagccc ggcgggaaaa cgggacaacc ggtcgtagcg caggcgccgg ttcgccggca
     3121 cgcggtacac gtgcggtccc tcctcgaact tcgcgtggga cagcacctcg tgcaggtgac
     3181 gagtggggag atcagcggcg aactccagga atccctcaac actcagcggc gcacgaagcc
     3241 cttgatagcc ggcaagagtc gcagtccacc gattgccctc gatccacagc agcgcggcgg
     3301 cacggggatt gcccggcgtg ggacccacca gcgcgccacc gtgccgcgcg gcgatgtggt
     3361 cgggaaccgt cacggtccac gtcgtgtaca cgaggtcgac atcgacgcgc tcttctgccg
     3421 gcgcctggaa gcccatggcg acgagccacg acgcgagctt gctgacacgg ccggtggtgt
     3481 cgacgacaag atcagcctcg atcgtgtcca cgccgtccgg cccgctgcag gtcacaccga
     3541 gcacaacgcc ggtctcgtgc agcagcccga gcacctcgcg gccatcgacc atccgcacgg
     3601 cgggcatgcg cagaaccgac tgccggacgg tgtgttcgag aaggttgcga ctgaccatga
     3661 ggcccctgag gtcactgaca ccgtgagcca tcagctggcc gtggttgtag aagttgccct
     3721 gctgcagaac gtcgtaagaa cgtgcgccgc cagccagcaa ctcggccgtg atcccgggga
     3781 cgagttcctc gatcgcctga cttccacgcg ccaaaagccc atgcgcatgc ttggactgcc
     3841 cgactcccct acgagatgaa ggccggccag cgatcgagtc gcgctccacg atcacaactt
     3901 cgtcataaac gctctgcagg gcactggccg cgagcacccc tgccatggac gccccgatga
     3961 cgaccgctct cttgctgcca ctcactccga aacaccactt tcacttgaat tgcgaattca
     4021 atttcaggac gaccacacga cgaagtgaca cgaactacat gaacgcgtac ccaccgggaa
     4081 atcatccggc tatagcgtca cgagaattcc acgatttccg agaccactga cacgacttga
     4141 attggacaca ccaatgcact tcgccaagat ctccgcagca gctctcgcga tcggagcaat
     4201 cctgctctcc gacggtcagg ccctcgcgtc gaccaccgcg gcgtctcaag caagcggcac
     4261 cctcgtgatc gccgagtaca agacccagag ggaatgcgtc aacgagtcgc tctacacccc
     4321 gaagagctac tgccggccca gtggccgcgg aacgtactac ctgctggtcc cggtcatcga
     4381 ggcgtgactc atcacagcag gccgccgacc ttggcgccac agggtcggcg gcctgctgcg
     4441 gttccgtcct cgaggtagcg aagaaaggaa ggatgaccga ctgcgcgact ccacaacggc
     4501 gtcaatcgaa gaacaccgcg tcgacctggt ccgcgctttc gcattgctgc tcaacgagcg
     4561 tgccgcgaca cctttgatca cctcgctcag gtgaggcact ctgctccttt cgcgccagta
     4621 actgcacacg ggtggacagg ttcggattcg cacccgtcga tcacccgaat cccgttgacc
     4681 ttctctcatt cgcgagacgc ccgcctacac agttgtgctg tgcttgtgac tggaaaccca
     4741 ggcacaatca ctcgatcatc aacaggtatc tctgcttctt gtccgctccg aactgacgtc
     4801 cgggagtgca gtggtccagt cagctggctg gacgagctca gcaccgggtc gaactctcgt
     4861 gcgttctcgg acgaccaagc gctgagagtg cctgtgtgcc gcgacgcgac ccgcgtcgga
     4921 cgatcggccg tgccctcatc cgctgtgata ctcaggagcg cccgtggccc cccacgtcag
     4981 ctatcccctg caggacgtcc ccggcatcga catctccccc gtggtgcgcg atctgatcga
     5041 tcgcggaccg gttcacccgg tcgacaccgc cggtgggcgg atcggctggc tcgtcaccgg
     5101 tcatgacgcg gtccaggaag tcctgcgtga cccccagttc agtcgcgcgg ccatgaccgg
     5161 cgacgcggcc gacccgctcg gaggtgcgtt cgaggggccc ggcgcgatcg tctcactgga
     5221 tcctcccgat cacacccgcg tgcgaaaggt catcgccgcg tcgttcaccc ctcggaccat
     5281 cacccgcctc cgccccggag tcgaggtgat cgccgagcaa ctggtcaccg cgatgatcgc
     5341 ctcgggaagc ccgggcgacc tcgtggcggg agtaggagtc ccgctcccgt tgatggtcat
     5401 ctgtgaactg ctcggcgtcc cgtacgagga tcgagcgacc ttcagccggt gggccgactc
     5461 catcatggcc atctcgtcga tcagcccgga cgaggcgtcg gcgaacaagc agtcgctgct
     5521 gggctacctg cacgatctgg tgcgtgcccg gcgcaacgaa gcacagcacg acctggtgag
     5581 tctgctggca cacaccccta ccggcgatgg gacaccgctc gacggactcg agatcgcgaa
     5641 cctctgcatc ggcatcttgg tgggcgggta cgacaccacc gcgaacgaga tctgcaacat
     5701 ggtcttcctg ctgtgcacca atccccactt gatggcacac gcacgcaccg gaagcaccgg
     5761 gctgaacgag acgatcgacg agatgatgcg gtggatagcg ctgtcgatca acgtgggttt
     5821 tccgcgcaaa gcgacccggg acaccgtgct cgggggacag ccgatcgccg cgggggacgt
     5881 cgtcttcccc gacgtcatcg ccgccaaccg cgacgcctcg gtgttcgccg atccgcacag
     5941 cctggtcccc ggccgcgaga accagcgccg gaccctgttg ttcgggtccg gtccgcactt
     6001 ctgccccgga gcgcatctcg cgcggaccga gatcgaggtc gcgctgtcga ccttgctcag
     6061 aaggcttccc ggcctcaggc tggctgtagc gccggaggaa gtcccgtggc gctggggaca
     6121 gctggtgcgc ggtccgcgcg aactgctcat ctcgtggtga cttcgcctct ccgctgacca
     6181 ccggcgagct tctcctcaca cggttcgacc gagcatcacc gcggtcacca cgccgtcccc
     6241 gtcgaagcga gacgcccacg cctcagaacc gcgctgaggc agtcaggaag tccgcgacga
     6301 gcgcaccgac ccgttccggg tcctcgacct gggggtagtg gccgacgacg gggtcgctca
     6361 gctcgaacac ctgcgccgca ggcattcgct cccggatcct gttcaggacg tgcgctccgc
     6421 tgatcgggtc tgcgggcccc cagaagaacg acatcggtcc tgcgaagttc tccaacgcct
     6481 cggtccaccg gcgctggtgc aggcgtcgat catggatgta gcgcatgagg gcgggaacga
     6541 ccctgttgcc acgcgcatgg gttaccgagc accacatttc ggcgagcacc tcctcactga
     6601 ccggcctgcc cagcacggaa cggagtgacc gcacgaacga ccggtaggac atggctcggg
     6661 ccacgcgcgg gccgagtcca ctgtggagca ggcgctgggc gaggaccggc cggtgcaggt
     6721 cggggcagag accgccgttc agccacgcca ccgaggtgat cctctccggg cagcgggcca
     6781 gcaactcccg ggccacgctc actccgtagt cgtgtgcgac gagatcggtg ctggcgatgc
     6841 cgaagtggtc ccagacagcc atgatcattt cggcctggtc gtggatgcgg tagcagtgct
     6901 ggagcggctt gtcgctgtgg ccgaatccga gaagatcggg tgcgacgagc cgcagatccc
     6961 tctggcgcag cgcgggccgc atcggagccc agtcgtggga cgagatgggg aagccgtgga
     7021 tcagcgtgac gttcggagcc gagtcgggtc cgtcggcgca gacgaagaca cggtgagagc
     7081 tgccgggcga cgacagcagc ttgcctgacg ccttcgcgag cccaattcgg caatttccac
     7141 gaccgcgtac atcagcagaa atcaagtggt acacaccact cgaatgtgta gttgcacgcc
     7201 actcgtgcgc actacgctac aaatcgcgat attgcgtcta attcaagacg gggagaagat
     7261 gggattttcc agaattctta ccgcatccac cgttgctttc gccgccctgt tgggcgcact
     7321 gccaggtgtc gccagcgccg atgtggttgt tcctcccaga ggccagtaca tcttcgctcg
     7381 attccccggc gaatccggtc tgacattccg gatcacctgt cgcaccgcga ccgcaggggc
     7441 cacagcagct gccgacatcg gctggcgata cggcgagaac gactggagag cgacgagcta
     7501 tggcgtcgcg acaccgttca cgtccaccta cagcaggccg aacacgtcga caaagatcac
     7561 ttttgtggcg aacaacctct cctacgaccg ctctttgtca tgcaacggca ccatcgtcag
     7621 ctgacttgag caagcacacc accaggccgg cagaaaacag caggttggtt caccactccg
     7681 catcacagaa attcagaaag gcatacccca tgcccagcac gaccaaagca cgtggcgccg
     7741 tctcgaggct acgcctgctt tcagctgcct tcgccgtgat gacgaccgtc atgaccgtct
     7801 cctcgatgcc ggcgacagcg gacgtgtcgg cactcgacgc gatgacgctg caacctggcg
     7861 cccagggcgg tctcgtggtg ccaggcaacg aacaaaagct gagcttctac gtggagtgcg
     7921 agacgaaccc cgcaggacaa gcggcacgcg ccaacgtcgc gtggtaccag aacggcagac
     7981 tcgtggcgaa cacggctgga agggcgacgc cgttcaggtc gtcgtggagc aggccgactt
     8041 cgtcggtgcg cctcgaattt cgggcaacca atgcggccgg cacggttccg atcaggtgcg
     8101 cgctttacag cgcctgatcg tcatcggagt cagtgcgcta gagcttcaac acaggagtag
     8161 ctcgcggcca gttcgcagcg ctgctcaaac agattgctgt tcaaccaatc aggaggaagc
     8221 aatgttcgac gaactcgaca ccttcgacat ggccgcgctg gagatcatgc ccatctccaa
     8281 cgactcggtg gaggccgcgc tcgcggcggg ccacggcgcg accgagatcg gcctctcgac
     8341 gtcgttctgc tcggtcggct gcagctttgc cggcccggtc gcctgaccag cgctctgagt
     8401 gaggggccgc cgcctcggtg cggcggccac ctggaggtag gtgtgcgagc agtcctgcgc
     8461 cgtggcgtgt ggatcgagtc tcggggtagc gagatcgttc tgcccggacc ggatggcgag
     8521 cttcgcttca gcggcgcggc gggacgattc atgtccctgc tctgcgagag actcgacggc
     8581 agcatgagtg tcgccgagct gcgcgctgcc gcgcccgctc acttggttga acggctcgac
     8641 gaggcgttga cgctgctgcg gtcgaacggc ttgctctcct gtggcgagcc acctgatgtg
     8701 ccactgatcg ttctcggagg tcctgcctat tggcgcgacc gagcaaaacg atcacttgtc
     8761 acgggggcgt cgtcttcgag gtccacggta acggaatccg ccgttcacgc ggttctgcgt
     8821 ggagacaccg cctggatagg accgctcgga tgcaccgaga cgcggtggtc gcagatcgag
     8881 tgccggctac cgccgttcac cggcttctca cacgatttcg ccccgccaga actggtggcg
     8941 gcggttctcg agctcgaggt gaagacccga cgccggggca cgtgcccaca ggtggtcgcg
     9001 gttcacccgg atggcaccac gtctcgacac aacgtcgtac ctgtgcgcag catgcgcgag
     9061 gacctgtctc gtgaacaggc gcttcgctgg tgcacagacc cggtgacggg agttctgcgc
     9121 ggtgtcggtg aaaccggtct gttccagggc ttcggcgttg cgaccaaagc caccgcggca
     9181 gcgtccggcc cggcgagtgc cgcggtcctg acagcggtcg ccgttgccga cgacctcgcc
     9241 acagcacgcg cccgcgcctg tgaacgagtt ctccgcaagc acatcacctc tgaccttctc
     9301 ctgcggcgaa ctgccaacac ggtgatcggc gtcggatccg acatgagcga ggcggcggcg
     9361 gaatgcctct cccaggtgtc cggcggtcca cggctgtcgg tgccggctga gcgcgtgcgt
     9421 gcgatcgtgg cgaccgcgcc gtccccgttg agggatttcg agcaactcct cgatgcggac
     9481 gaccggtcgt gggcggtgac ccagctcggc gacgaagtgc cggtgctgga gttctggctc
     9541 gataacaggg tcgtcggtcg tttctgcacc cctacccctg aacgcaccgt ggagcgcggt
     9601 gtcgagtccc tgttgtccgc tgccgctgcg ggcgtgcagc gcgagcgggg acgcacggtg
     9661 atcggcagtg caggtgtggc gccctcctgg cggacgtgcg gcgatccgtt gacagtcctg
     9721 gggaatcgca tgaatccggt ggaatcccgc gatgaggccg gcagtccggt gtggcgagcc
     9781 gctggagtgt cgtgccaggt cgaggtgtgc gttggctgac gtcgtcgctg ttggcgaacc
     9841 tgacctggtg aagcggctgg ctcccctgtt gtccccacgt ccggagaaga tgccggggta
     9901 tgcgttcatc ctgccgggag ttcaagcggt ctaccgcctg ctgtactcca cgtcggtcga
     9961 acggggtgtg ctccggcggc tgccggagca cacgcgctgg gtgacagcgg tgttcgacgg
    10021 cggatccgtg atcatctgcg cgggacaggg agttgccggc agctgtgcgc gctgtgcggt
    10081 caggcgcaga aaggccctgc actccggacg ccgcgacgtc ggcgaccaga ccgcgcacac
    10141 ggctgccgag gatcgactgg tcgccgcggt tctctccgcc gtcctcgaaa gaggacttcc
    10201 cgatgacacc ctcgtccggc aggttcgacc cgctgttccc gccgtcaccg atcatcggct
    10261 gatccgagat cccggctgtg aggtgtgcgg cgaggacggc gagcccagct acgatcccgt
    10321 accccgaacg ccgcgtcccg tgctgcaagg ccgattccgc ctgaccgatc tacgcggtgc
    10381 tggagcagta ccgctgctcc ggtgctcgga cgaggaattc ggagtgacga gcaacctggt
    10441 tcgtcaccac cccaccacct ttccctccgt gtcggcgagc gtccccctcg gtctggacgg
    10501 cgccgccgat cgcggatacg gccgagcact ggactcgtgc gatgccgagg tcgtcgccgt
    10561 cgcggaagcg ctggagcgcc gggcggcccg tcaccatcgc gatgcggcag ccgtggcgtc
    10621 ctcggcgcaa ctgggcgacc gggcgttcga cgtgtcgtcg ctcgggcttc cggttggccc
    10681 gcaggggttt ccgtaccagc ggctcacccc tgacgtggag ctcgcctggg tgaccgcgtg
    10741 gtccgccggg caggaccgcc tcgtgctggt tccgaggtcc gtcgcgtact accagtcgtg
    10801 ggcaacgggg gccgaccagc ccgtgctgca ggagacgtcc agcgggtgcg ccgtggggtc
    10861 gtgcctcgaa gaggcggttc tgcacgcctt ggtggaggtg gtggaaagag acgctgtcat
    10921 cactgcctgg tacgcccgga ccccgttacc cgaagtggat ctcacgacgg tcaccgatcc
    10981 ggaactgcga gttctgatca ccaggatgcg cacccggtcg ggttatgacc ttcgagcctt
    11041 ctgggccact cgcgacatcg cggtgccggt gttctgggtg gtcgcgaccg ctccccccgg
    11101 ccagccggat ctgcccgcga tcgtgtgcgc gtccggcgcc gctccctgtc cggctggcgc
    11161 gctgcgtggc ggccttctgg agctggcggc ggcgctggac cacaggcgcg cgtcctggcc
    11221 tggcgacccc gaacagcgac accgcgcggc gaggatgctt caggatccag gcctcgtcca
    11281 ggacatcacc gaccacggac tgctgtactg ccatcccgac acggtgccac ggtggaactt
    11341 cctgcttggt cacggcgcga tgcgaccgtg gcgcgagttc gcgaagtcgc gccggccgag
    11401 ccgcggcgat ctgctgctcg actgccgcgc gctggtgcag gagacgctcg cgcggtgcgc
    11461 tgacgtcctg gtggtcgacc agacgacggt cgaacacacc accgcagaac tgcggtgcgt
    11521 gaaggtcctg gttccggggg cggtaccgat caccttcggc cacaacgcca gacgtgtcct
    11581 gggcatcccg cggttggacg ccgccttgac ggcctcggca cgtgccctca cctcgcaccc
    11641 ccatcccttt cagtaggagc aaagcgtgga cgacatcgtg ctgccggtgg cagtgaggcg
    11701 cgcggggttg cgatcgaccg acgcgacggc gctggtgtcg gccccgctgc gagcgcgcct
    11761 cgatgaactg gtgcgacggg agcagcaggt ggacgtgctc gtcagccggg tgaccgatgc
    11821 tctccacgac gtcatcgcga accgcgctca cggcgacggc cggggcgaac tggtcggtgt
    11881 gcgccgggcg gcgcacagga ggaaggtgcg ggccgcggac gtgcacatcg cacgcacgtg
    11941 gtctggagac cggatcggtg acgcggtggc ggaggtcgcc gcccggtcgg ccgagatcga
    12001 ccggctcggg gccgaactcg aagtgatcgt gaccgaacac gagcggtccg ccctggacca
    12061 ccttcggcgg gtgtgtgcgg acccggtggt gcagcgcggt ctccgctcga cgcttccggc
    12121 tgtcgccgac gcgatcctgc cctggctgcg cgggggcact cctcccggat ggcggctgcg
    12181 agcggcgctg gtccgcctgg tgtgccgtgc ggcggtgaag acgagccccc tgtcctcgtt
    12241 cctggtccaa ggcgcggccc ggtggcacga cgagctcgcg gacagcggca accggaccgc
    12301 cctcgtggtg gaaccctcgg tcgagcggct gatgcggctg cgagcggtta tcgctcggga
    12361 accgcggttg tggccgcgac tgtcgatccg gctcaatccc ggtctggtag cgcacaccga
    12421 tcgtctcgtc gtgctcggcc ctcctccctc cggcgacgtg gcggagatcc cgctgactcc
    12481 tgcactggaa cgagcgctgg cactgatcgc ggaccggacg ccggcgacga cgcaggacgt
    12541 cgcttctgcg ctgtcacgtc gaccggacca gggcgagctg cttgtgcggc ggttggtcga
    12601 ggccaacgtc ctcgaggtgc acgttcccgt ggcggaccag gacccggagt ggccccggac
    12661 gttgctggcc tggttgcgtg aacgctcgac ggacgcggaa ttggtcgcgg cgctggaaga
    12721 actcgccgcc gcgccggcga cggagcgcct ggacgagtgc ggccgcgccg tagagcgcgg
    12781 tgttcatcgg gtggaccggt ggcttgccga tcaggcggca cctcgcggca caggcgcctg
    12841 ggcaacagag gaaatggtgg tgagcgaggc gatagccgtg ccacgcgcgc ccgcgtttca
    12901 cgtccgggac gatctgggtc gtcttcggca ggtgctgagc ccgttcgact ccacgctgcc
    12961 ttatcgcgcc gcgctggccg gtttccacgc cagcgccttc acgcgctcgc ctgtcccttt
    13021 tctggtcctc taccaggaac tgcatcgcgc gcttcgcgat cccggccacc ggcaccacat
    13081 cgcggcccga gccgtccagg atgccgcggt gtggccggga aatgcgccgc ccggtccgga
    13141 gtggaacctc ctcagggacg ttctggcggc acgctcggcg gcggaacgaa cgctcagatc
    13201 actcccctgc gacgaggaag aagtcgaggt gccggacctc gagccgatcg cgctcggtgg
    13261 ccggtggtca cttcccagga tcgcggtgct cggacaaccc ctgccagagg gcaggttcgc
    13321 cgtgaactcg gtcgttcccg cacaggcgtg gggagcgtcg cacgtggaca gagcgttgcg
    13381 gcgggccggc tttgccgggc tgagggccga gccgccctca gacgggggtg cggcactcag
    13441 gatcgaggtg gagaacgtgc tggggcatcc gctcaacgca cgcactcgca ccacgacaca
    13501 cgtactggac tatccgtcac tcgtctcgtc ggccgcacgg gatcggcggg tgccgatcgg
    13561 tgagctgatc gtggtcagcg atcagtccgg gctcctccag ctgcgctgga gcagagagga
    13621 cgtggcggtg gagcccgtgc acacgagcac gctgtcaccg gcctttctgc ccccggctct
    13681 gcatctgctg gtgcacgggt tctgcgccga caccttgacg ctgtatccgg ggcgtctgtg
    13741 gctgcgccgg cccagcgccg acgatcggtc cgatgtggtg tcgcacccga gacttgttct
    13801 gggacgcttg gtgttgcgcc gccggtcatg gtcggcgtgg gtcgacgggt tgccgcgacg
    13861 ggccgcgggc gagacaggtg ctcaccacct cgttcgctgg gcacggtggc ttgcggaaca
    13921 tggcgttccg gaacgttgtt tcgtgcgtgc ctatcaacac gactccaccg ctgcgtcgac
    13981 caacacaacg aaggcgagga agcccctcta cttcgacctg ggctcgccgc tgctcgtgcg
    14041 cgcggtcgag gattcgctgc ggggagcggg cgggatcgct gtcttcaccg agctcgcgcc
    14101 tgatcccggc agtgccgaca gggtcgagga acacgttctg ctggagggag aagtacggtg
    14161 aacgacacca gctgggtgtg cctgcacgtg cacctgtcgc accgtcaaga cgactacctg
    14221 cgcgatgtcg tgcgaccgct cttccagtcc atgatggacg gagaactggt ggaccgctgc
    14281 ttcttcctgc gctactggca ggaagggccg cacatccgcg tgaggcttca tccgagaatc
    14341 agcgccgatc gagcacggat ccgccacgcg ctgctggaga acagctccga ctggctgcgc
    14401 gagggtcctg ccgcacccga aatcgacgag cggtcgtggt tggacgcggt acggccgtgg
    14461 gcagccgcgg agggtgagcg cgacgtgctg ccaccacttc cgcacggaag tctcgtcgag
    14521 tccacctacc ggccagaaca cgatcgctac ggacgcggcg cggtgctgga ggctgtcgag
    14581 cggcatttca ccgactccag cagactggct ttgcgccatc tggaacatga catgcccact
    14641 cgggcgaggc tcacactgac ggccacctgg ttggcggagt cccacgcgga ggggctggta
    14701 tccgacaacc ccgccctggc gggatcccct ctcgcccact ccgtcgcgga gctggtgcac
    14761 gcccttcgca cagccgacga cgcaccaccg atctcgcgag tggtccgcga ctgcgcacac
    14821 ctgttggcca accgactggg aatcggcccg cttcaggaag acgccttgcg cgcactcgtg
    14881 ctcgcgactc gagcggaccg ggcgttcgca tgagtgtcgg gcaatgggcc gcggcgcgcg
    14941 tgcactacta ctcgcaagat cgcgatgccc tggtgttgcg tgcggtggct ccgctcctgc
    15001 ggtggctcga agaccgatcg gttcccagtt acttcgcacc gcactggaga ctcggtcccc
    15061 acctgcgcat cgcagtcgca ccgcgaaccg ggtcagagga tctcctggcg cacggcgtcc
    15121 agactttcgt cgaacccttc ttgctgaacg aaccctcgac cgcacgcatc gaccccgacg
    15181 cgctgcggac cgtgcacgag caactggcct gggacgagca ggtcctcgag ccgctgcacc
    15241 cgctggcgcc ggacaacagc gttcacttcg gcgtggagga cgaccggtcg ggcgtggtgg
    15301 gaacggagtt cgccggcctg gtgcgtgatt tcgacgtcgc tgcctggaag cactccgtcg
    15361 acagctatcg gctcgtggag gcaggccgtt ccaagttctc cctggctttc gacctgctcg
    15421 cttcgacggc actcatcgcc acaccggagc gtcatgatcc cgtctccggg ttcggatcga
    15481 tgcgaatgca ggcggagcgg ctggtcgtca ccgcgtccga tcctgttcga gtacgacagc
    15541 actgcgaatc gctgtacgac aggctgcgcc cggcgttgat ccgccgcctt cgctcgatcg
    15601 tcgacggcgt gcccgacggc gacatcgccg gtctgcgatg gacgtcgttg atcgagccgc
    15661 ggcgcgatga ggcgacggct ctgcaccgcc gtggcgtgcg catgccgatg gccagcgcgg
    15721 atcctgccac gtggggtcgt tatgcggagt ccgtgcgagc cagtcctctg cacatggcga
    15781 cgatgggcga tcccgcccag ctcgaacggc tgtcccgttg cgactggcac caggggtacc
    15841 ggttcgcggt caacctctgc tacctgcagt tgacccgatt gggcatcacg gcgtcccaga
    15901 ggctgcaggt ctgctacctg ctctcgcgca cggcgacgga tgtcatcggc accctgacca
    15961 gcccagatcg agtaggagcg tgagatgcac ccgcttgtgg aacgtttcgc cgctttggcg
    16021 cgactctccc aggttcaaga gcagccgtcg ccggcgcacc ttccgggcct cggcaagtgt
    16081 gcgccgttca ccgccgtcac cgccgccgag gtggaaggcg tgatagggcg gcacggactc
    16141 cgcagcgaac aggtggtcgt caccaggcac ggcgtcgtgg taccggcggc ccagtacacc
    16201 gcgaccgcgc gaatcgaccg cgttccactt cccggtgtgg tgaggcacgc agcgctgttc
    16261 gacctcgtgg agagcgggca caccctggcg ttgccggggt gcgaactgtg gctccccggc
    16321 atcgcggtgt tgtgtgatca actgcgctct gccctcgccc agcccgttct ggcagggctc
    16381 ttcctgactc cggcctcgga gacgggactc agcgtgcaca cggacgccta tgacgtcctc
    16441 gccgtccaaa cgaccggcag caagcgatgg cgggtgttcg cgaagcgtcc ggagccggtg
    16501 cgcaacgcac ccgtggacgt gtcggacgaa cccgtcctcg atgtcgtgct tcagcagggc
    16561 gatgcgctgt tcgtgccacg cggctgcccg cacgtcgctt ccgccgagag tttcagcctg
    16621 cacgtctccc tgggagtcca ggcgatgacc gcacgggagg tcctggtcgc ggcgatgcga
    16681 tccgccacct tgtcggccga cctggatgcg ccgatgcctt accgggaagt cggcgatctc
    16741 aacgaccggc gggctgccgt gctgcgtcgc gcgagcgagg cgttgctgac aggactgtcc
    16801 tctgaccagg ccgatcgggt ctaccaagcg ctgtcgtcgt cgacgacgac agcgccgtcg
    16861 ccgggccggc ttcggaggct cgagtcagcg gccgagatga cggactcgcc ctcttggccg
    16921 ggcaccgcac cgtgacgtct gcgtcagaac cggcaggttg agccgcagag gatcccgacc
    16981 gaccggcctt catcgcccgc gaccaaggga cttcagccct tcatccgccg gagcgcttct
    17041 ccgtccgtgc agcggccgcc tcggcgaacc tgcgcaggat ctcgtcccgc cgtgcgctga
    17101 acttggctta ggtggccgac atgaggtccg cgatgaacgc cgacccgtca ccaaacttct
    17161 tccgttcctg gggcagttcc agcacggcgt gcgggtcgaa gtgcaggatg acgtcgatcg
    17221 gctccagtcc ctgcgcgact cgttcggcct gttcggagaa gcctcgggac aagctgttgg
    17281 cccggatcag catggccgct cgaaccacct cgacaggcgc gctcgaaccc gtgccgttga
    17341 ggtggtaggt gacgaggttc tgctggaagg cggtagcctt gtccggactc aggtggaaac
    17401 gcgcgctgtc gccaaagccc gtgatcacgc cgtagatggg tcttccggtc gcgatcaagc
    17461 gatgccgcaa ctcgacagac cggcgcatgc gcgcagccgc acggccgtcg atcctcacgg
    17521 acagatcctc accagctcgc gccaccgcaa cgacctggtc aacactcaag ctgtcgtcgc
    17581 ccaatttcac gccgacgtct tcgccgcaca tttcccgtga cgccgacgag tcgctgtcat
    17641 cagcaacaag gttgtccgca cgaaacattg gtacctgcct tcattcgcga gcggcgcgag
    17701 ccaccgaaat tcaggcgatc tcacatcgac gccggagatt atccagacgg aagacaaaat
    17761 ccccacacgt ttgtgtagcg tgtgggctca tcatttcccc accgcagcct tggtcatcga
    17821 accaggtctt cgcggcgtca ccctctccgc cgcacctcgt cggcgatcgc gctcgcgcgg
    17881 gacgggccac gcgtgaagag ttccgggtgc acgtgcgggc cgagcgcagc gtcttcagcc
    17941 tcgaccggcc acgctcttcg cgggctgcag gacgtgcaca cccgacgtgg ccgtcgatcc
    18001 gatcccaacc gcgcggcccg catcgaccaa gcgggccgaa gtcgaccatc acaacgatgt
    18061 gcggatgcac agagaacgcg acgcaaacca tcgcccgcag gacggacact gggagagcac
    18121 gaatgaaaca cggcgactcc cacagtttcg tcgccggatt gcaggggtgc actcgggttc
    18181 gtccccgaga gggctccatg cgcatctctc ctggcgcgtg gagccctcct gcgtgccatg
    18241 gagatcgatg aacgagtcag acgacaccaa acagcaggcg cacaaacgtg cattgccgac
    18301 aagcagtgtc ctgagtggac taaacgggca ccaagtccac tcaggaggat gagatgaagt
    18361 acatcagccc agcgaagatg gcactgctcg gcgcgtgcgc ggtcaccgcg atgttgtcgg
    18421 cggcaggtca agcctcggcg gcttccgcga acgactgctc gcagacccag agctcgcccg
    18481 gcagcatcac cctggcgtgc tctggcgtcg gctccagcat cggcgctgcc gaggccgagg
    18541 ccgagcggtc gctcacattg tggtggaacc gtgacggcag gcggcactcc tgtgcgggcg
    18601 tgtcggagca gcagtacatc atcaccaacg gctacaaggt cgtggccaac tacaggtgct
    18661 cggtggccta gcacgcctcc agccgcagcc gggaccgtcg gtcgaccgcg gcgacaatcg
    18721 gccgacggca caggagcggg tggtccgcaa tcgcgttcct cgacgcgacg gggccacccg
    18781 ctcgatccct ggcaggaagc gattccgaca gggatcccct ttcgctgcgc cacaaagcac
    18841 acatgggtgt agcgcgacgc acgcgcactc cgaagacgat gcagcggtgg tgagcagcca
    18901 ccgcaacgtt gacacgtctt cgacaggagt cccggtgcct cagaccccgc tgatcgcagc
    18961 aacgatgttg ctcgcgtgcg ccttcgcgac atcgacaccg gccgcagaag ccgcctcctc
    19021 cgcggatgcg gtgagcatcg ctcctcgtca gacaggaggt ttctcctggg accgcgaccg
    19081 cgactggcca gtcgtgtcga tcacttgcac tgctgcaacg acttctcccg ccagggtttt
    19141 ctgggagcac aagcagttcc agaccgatgg cgcatgggtc accgcgaacc aaggttcgaa
    19201 gtccacgaac ttcgtttctt cgtacaactc gttcactccc tactcccagg tgtatcgagt
    19261 cagggtttcc aacgattcgt gggatcggac gatcacatgc gccgccacgc gagacttcac
    19321 ctccacgaca tgaggctgct ggcaacctcg gttgcaccag cccggaagtc cgcttcccgc
    19381 cggcaagcga tcctcaggca gaaaatcctg cgaccacaca gttgtgcgcc tggatgacct
    19441 gatcgtcgta gacgatcgcg acgagtgctt cagccgtcct ttctggactt ctgcggaaaa
    19501 tccacactgg attcgtggtc gaacaccatg tcctccagcg cggactgctg aatgttcact
    19561 cgtcatgacc acatggttgc ttgccgagcc gccgcccctc gtcctgatcg gctcgttcgg
    19621 tccgcgaatg cggaagacag cgagagcccg gctcggaggc gccacctcca ccaggggaaa
    19681 tgatgacaaa ggcgaacgct gcggctggac acgacgcaga agcgacgacg cccggtgaca
    19741 cgaccaggcg gtcgttcatc ggaggagctc tcgctaccgg tgcgctgctc accgcgggaa
    19801 caggtacggc atcagccgca gaagacggta agaaccggcc ggcgtggcag atcgaacgca
    19861 ctgaacttct gtgtcagccg tatctgctcg accccgacgc ggacagcgtg cgtgtggtgt
    19921 ggcacaccga aacacgtggc gtcatgcatc gggtggtgta cggcgagggt gtacgcaacg
    19981 ctgatgacgt cgacgtcata gcccttgcac taggcggccg ccgccgcgga cgtgatcaga
    20041 gggtggcaag cgcacagacc gctcgtctgt cgagaatgcg cgaggatgcc gagtccaaca
    20101 gttccagcgg ttcgaagccc agcaccgtgg tggaacggca cgtgtaccgc catgtcgccg
    20161 tagctgaagg tctgacgtcg cgtcgcgtgc cctaccgcgt cgtgtccttc gacgaacggt
    20221 ggcgggtggc gatcactccc gtgcacacgt tgtccgcggt ggcgcgagcg ggcgaaccag
    20281 tgacgttgct gctcaccagc gaccaccagc tcaagaccat gacacctgcg aacctcgagc
    20341 tcgtggggca gaccgtggga accgaactcg acggggttct catggccggc gacctggtga
    20401 acgtgcccga ccgcgcgagc gagtggttcg acgatgcctc gggcctggcc ttcttcgccg
    20461 gcatgaccgg acgagcccac cgcgagatcg cgggcaggat ctaccgcggc gctccgctgc
    20521 tgcagaacag cccgctgtac cccgtgatcg gcaaccacga agtcatggga cgctactcca
    20581 ccaccaaccc tctcagcgcc cagttcaacg atccgcagcc gcgcaggatc gcgatgcgcg
    20641 accggaccgc gcgcggttcc gttgacgaca ggtcgtggaa cgtgcggacc tatgaggagc
    20701 tgttccctta cccacgcagc aactcagggg gatcgcggtg gtggtcgcgc accgtcgggg
    20761 acgtgttcct cgtcggcctg ttcgtcacgc agatctggcg cgttcccacg gccggcgctc
    20821 gcggcaggta cagcgaggca gagtctgacc tgcgctcacc ggaacgctgg ggttacggcc
    20881 agttcccctt cgaatccgtg gccaagggca gcgagcagta ccggtgggcc cagcgtgagt
    20941 tgtcctctcc cgaggcccgc cgtgcgaagt accgcgtggt gatgttccat cacccgtccc
    21001 acggcctggg tgacaactcc gcgccaccgt tctcggatcc ggagcagtcg gtcgagcgcg
    21061 accctgcgac gggcgaggtg agcgcggtgc gctatcacta ctccttgcag cgcgacgaga
    21121 tcctcaccga cctggagccg atgctgaaca gccacggtgt ccacctggtg ctcaacggcc
    21181 actcccacat ctggaacagg ttccgcaacg cccgcggcat gcactggctc gagacgtcca
    21241 acgtcggcaa cacctacggc gcctacgaca cgagctctgg tgcttcccgc gctgttccgc
    21301 agtctcccga ctacgtccag cagggtgatc ccggtgggct tcggcccgtg gttccgacca
    21361 tcgcgccgct gaccggtccc gacgggacgc cgttgccgtt cgtgtcgagc aattcggtca
    21421 ccgcgttctc agtactggac tccggtcgcg gagtcgtgcg gtcgtaccga tacgacacgc
    21481 gaactccaaa agatgccgcg gtactcttcg acgagttctc tcttctctga cgaacagttt
    21541 gaaagatcgc ttgcaggcgc tttcggcacc agcaagcgat ctttcaacac cagcacaatg
    21601 gcccggcgac tcatcgagtc accgggccat tgtcaccgct aggccttacg tgtaatcgtc
    21661 ttccatcatt ccaggtcatc ccccaggatc aaccgatgtt gaatccgctt cccagcgcgt
    21721 tggccccgtc gcgaacggtc ctgctcgtcc ccgtgccact cccgcccggc gtcgccgcga
    21781 acgaggtgat ggtgatcgtc gcggggatgg ggtagggcgc acgcggattc tggaacttgc
    21841 cgagcccgct gacgttcgcg tcgagggtgt agttcgcgcc cttgggaacg acgacgttga
    21901 tgtagatgcg ctgcgacgca ccgctcgagg ggcaggcgcc gcttgcagac ccggatccgg
    21961 ccgcaccagt cgcggtgacc gagatcgacg gggtcaacct gtactcgtgg tacgtgatgg
    22021 agcccggcgt cggggagtac gactccgatg cgagcaccgg gcactggatg gacacctgga
    22081 agtagccgtt gaccgccgag gcctgccccg cggcgagcgg ggagatcagg acagcggacg
    22141 cggccaacgc aaccgaggcg gcgcgtgcga gacgcgggag cttcagactc ttgctcatct
    22201 tttccttctt cgcagtcggg ttgctgaaac gctgaagaga tgcgaccgtc attggacgat
    22261 cctggaattc gagatcgtgc cgttggtggc gtagagccgg aattccaggc tgtcgatggg
    22321 aaccgagctg aaggtcgcga cggtcctgct gtagttgcag aagggagcag gcgcttcaca
    22381 cgcaccggtg atgatggact tgacgccgcc attcacgagg atctccgcct tgtagaggcg
    22441 tggcgagacg gtgaagtcga cagtgatcgt cgccgaggtc ttaccgggtt tgacggcgaa
    22501 gaagacagaa ccgctcggcg tggtcggata gccctcagcc acagaggtgc ctgccgtgcc
    22561 gaacagcgac gcgacgatgg ccaacaagac gaaggccacc gaacccttct ggcgcaacga
    22621 cgtgttcatc acttctcctt gaaagccgca tcagaggacg tcttgcggga gaaatagtct
    22681 ggtgtcgcgc ccgcattgaa ggcacacatg tgtgtacttt ctcggaacga gctgggtcag
    22741 gaactcgact tttcctgcga acaacgagta acaggcctca taatcgaacc gcgcgatcca
    22801 ccgcgtgacg aagagatatt tcgcgcccaa cgaccgtgca gatgatcggc gcaaagtgcg
    22861 gaacttccgc tcctcggcat cgggccggca agccgcacct gacccgcgtc gtgaccacct
    22921 gagcatggcc acgtgatgag gacgtttcgt cggtgtgcag aggccccacg cctgctgaat
    22981 gatcacacat atgtctggtc ggagcggtct ggacagcgtg cgccggcatg gtgcgcttcg
    23041 gccgaacgac caggatcggc acagcggaga ggcttgacca ccggatgagc ggcggggact
    23101 ttgcacactc gggagacacc cgcgagcaag cggaactgga cgcaggaaac gaccttcgcg
    23161 tctcgacctg gtggggcgga gaatgggcgc gggccctcaa cgcgatctcc ttcgccgtca
    23221 aggatcacga tcgcaggttc gtccacgtct cccccggttt cgccgaccgg ctcggcacga
    23281 gtccgcagca gctgatcgga ctcagcgacg cagacctccc gggcatggcg gaggccgacc
    23341 ggtatcgcat ccgcgcggaa gaagacaccg tcatctccgg caaccttcct ctggcgatca
    23401 ccgtcagatt ccggcagcgc gatggctgga cagggcacgg cgtgggcatc cggttccccg
    23461 tcgccgggcc cgacggccgg cccggcgtcg gatcgttgct gctcgacatc accgagcacg
    23521 ttcgcgccaa agaacgattc gcactgttca tgcagcactc gggtgccttc ggtgcgatca
    23581 aggacttgaa ccagcactac atctgggtca ccgacacggt cgccaagcac catggccgtc
    23641 acgtcgacga ggtggtcgga cgaacaccgg ccgaagtctg cgatccggag gtggccgagc
    23701 tcgagctcgc tcaggacacc gcgatgctcg aagccggcgg cggacccatg acgttcgagt
    23761 tgcgcgaccg cggcgccggc gacgcgccgc tggtgcgtcg aggaacccgc ttcacgttca
    23821 ccgatgccga cggccgcacc tgcatcgggt cggttttcat cgacgtcacc gcagaggtgg
    23881 aagccagtgc gcgggcggcc gcagccgagg agcggttcac ctcgttcatg aggcacaacc
    23941 cagcggcggc ggtgatgaag gacgcggaag gccgttacct gtgggccaat cccgcctact
    24001 tccacaccta ccgggtcgat ccggaccact tcgtgggcag gaccatccac gatctcaccg
    24061 acacggagac ggcggcgtac gccacggctc tggaccagca ggtcatgtcc agcggtcagc
    24121 ccctgcgcga cacgtcccgc cacacccgcg gcgacggcag caccggggtg gacatcggct
    24181 accgcttccc cctaccggca ccggacggcc gaacaggact gggtgctgtg tccatcgaca
    24241 tcacagagct gcacgaggca cgcgaagcgg cgatgcgcgc cgaggcgcgt taccgagagc
    24301 tgttcgagca cagcgggata cccatcatcg tgttcgacct gggcggcaag gtcgtgaacg
    24361 ccaacatcgc gtacgcgcag atgatcgggc actcgctttc ccacctacgc tccctgcaca
    24421 tccgtgacct cgtgaccggc acgacggcgg tcaaggacaa gcctcgctgg gacaagctgg
    24481 tcagcggcga gatcggtcgt taccggtcgc gtgcgatgct ccgccatgcc aaagggacgc
    24541 tgagcgccgc ggtggcgacc atgagcttga tcagcagtcc ggacggcaca cctcagtacg
    24601 tctactccgt caccgacccg gtcgcggaca tcgacacgga tctcgctccc cgagcggcga
    24661 caggtcccgt gccgcagctg gaggaagaac gcctctgccg cgaggaacac acaatcctga
    24721 ccacgctcgc agcaggtggc acgctcgcgg aagccgggac cgcactgcac ctgtcccgcc
    24781 aaggcgtcaa ccaccacgtg acgaagttgc gcagacgcct tggcctgccg gagcgaaccc
    24841 gcaccgcggg cctcgtggcc cgcgcctacg cggtgggcat cctggtaccc gggacctggc
    24901 cgcctcacac ggcggccccc tacagctgag gctgcgggca agcccgccca gcagcgccgg
    24961 ccgccgacct gccccgccgc ccggccggcc accagttggc gtggccgagg agctgcatgg
    25021 tggcgggaac gaggatcatg cgaacgatgg tcgcgtcgat ggcgaccgcg gcagcgaggc
    25081 ccaagccgat gatcttcgcc ggcagcgcgt ctccactgac cagtgcggcg aagacagcga
    25141 ccatgatcag ggcgcaggac gtcacgacgc gtccggttcc cgcgactcct tcggtgaccg
    25201 ccgcggtgtt gtcgccggtc tcgaggtagc tctcccgcat ccgttccaag aggaacacct
    25261 cgtagtccat cgagacgccg aacgcgatgg agaagatgag cacgggcgcg aaagcgagga
    25321 cggggccagg tcggccgacg ccgatgagtt cggctcccca gccgagctgg aacacagcga
    25381 ccacgacgcc gaacgccgca ccgatggaca gcaggttcat cgcagcggct ttgagcggta
    25441 ccaacgccga gcggaacagg acggtcagca tgatcatgct ggcgaggagc actccgccga
    25501 cgagccagag cagcctgtcc tgcagagtcg cggccagatc gataccacga gcggtctggc
    25561 cgccgaggtg caccgggctg cccgtcgtgc gggtgaagtc ggccatgacg ccagcgcgca
    25621 ctttcgccac cagctcggcg gtgcgctcgt cctgctggct gaaggcggga gtgatgcgga
    25681 agaaggcggc gtcggcgtcc acggaccggt tgggagtcac ctcgctgact cgcacgacgc
    25741 cggtcagttc ggcagagcgc tcggccagcg tgcgcacggc gtcgagatcg ccaccgcccc
    25801 tcgtcaagtc gacgacaacg gtgagtggac cggtcgagcc cggcccgaat ccggaggcga
    25861 gcaggtcgta ggcacggcgt ccggccgagg actcggactc gttgctcgcg tcgacctgac
    25921 cgagtctgat cgacaacgcc ggtgcggcga ggatcagcag gactccgacg gcaaggaccg
    25981 ctg
//
