LOCUS       NZ_CP099738            22610 bp    DNA     circular CON 27-AUG-2024
DEFINITION  Lentzea sp. HUAS12 chromosome.
ACCESSION   NZ_CP099738
VERSION     NZ_CP099738.1
KEYWORDS    RefSeq.
SOURCE      Lentzea sp. HUAS12
  ORGANISM  Lentzea sp. HUAS12
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Lentzea.
REFERENCE   1  (bases 1 to 9676923)
  AUTHORS   Ping,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-JUN-2022) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024125735.1-RS_2024_08_27
            Annotation Date                   :: 08/27/2024 06:34:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,161
            CDSs (total)                      :: 9,080
            Genes (coding)                    :: 8,988
            CDSs (with protein)               :: 8,988
            Genes (RNA)                       :: 81
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 92
            CDSs (without protein)            :: 92
            Pseudo Genes (ambiguous residues) :: 0 of 92
            Pseudo Genes (frameshifted)       :: 21 of 92
            Pseudo Genes (incomplete)         :: 77 of 92
            Pseudo Genes (internal stop)      :: 3 of 92
            Pseudo Genes (multiple problems)  :: 8 of 92
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:47:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4169614
            Orig. end                         :: 4192224
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP099738.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Ping Mo.
FEATURES             Location/Qualifiers
     region          1..22610
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="19"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22610
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22610
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12610](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12610
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    1632..1647
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.53"
                     /tool="antismash"
     misc_feature    1726..1741
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.05"
                     /tool="antismash"
     gene            1830..2756
                     /locus_tag="ND450_RS18330"
                     /old_locus_tag="ND450_18330"
     CDS             1830..2756
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012422.5"
                     /locus_tag="ND450_RS18330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_18330"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_143091907.1"
                     /transl_table=11
                     /translation="MFGHLGVAPELTAVYELLVTGGSRTTDEIGVNASLLERMREFGLV
                     RHLPGDVWQAVAPDLAVEALIAAREEQNRRARADVGPLMELYLRNRGEELADNAFVEVV
                     SGVDAVRELWHALLRGARDEVCVLDQPPYVTPLGQHVALEDETRERDVQWRVVYDRSAV
                     DIPGRVTEIIELVAAGERARVTPTLPFKLAVIDTHAAVLPVVNGDVVDKVLLIRPSALL
                     DVLRSTFELYWDKGIPFSPGGIYAAAADVDPNLLGLLAAGLTDESIARQLGLAPRTVQR
                     RVRQLMDRCGAQTRFQAGVQAMRRGWL"
     misc_feature    complement(2809..2824)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 23.65"
                     /tool="antismash"
     misc_feature    2821..2837
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.58"
                     /tool="antismash"
     misc_feature    complement(2824..2833)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.15"
                     /tool="antismash"
     gene            2831..3403
                     /locus_tag="ND450_RS18335"
                     /old_locus_tag="ND450_18335"
     CDS             2831..3403
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS18335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_18335"
                     /product="hypothetical protein"
                     /protein_id="WP_253327289.1"
                     /transl_table=11
                     /translation="MRMLKVMAAALTGLALIGITGTASASADVVWPPKDVTPIHKTKAE
                     LEVQAAGFTARQQETFPKVFRGAENVSPGNWGGEAEGRLFDDMQYMTNWTGFTVQGQSN
                     TVFMQVNAPGFFQESPQQLCERDRCTGKVSDHRGGVTVFTKNDQHGITIAWNFRRNGEV
                     VWAQSWTAGTEAQLAAVASDRAYTFTR"
     gene            complement(3458..5335)
                     /locus_tag="ND450_RS18340"
                     /old_locus_tag="ND450_18340"
     CDS             complement(3458..5335)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S41"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015531.5"
                     /locus_tag="ND450_RS18340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_18340"
                     /product="S41 family peptidase"
                     /protein_id="WP_253327290.1"
                     /sec_met_domain="Peptidase_S41 (E-value: 1.2e-11, bitscore:
                     43.5, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATAHPNIANSVGLAEFLATAGTLTLAQRKLIVDQALILLEQNY
                     AHLPLKVAMHAVNPVQRLRVLRARLERQTDATAEAEWQFHRELSSTFHSVRDLHTNYLL
                     PAPFAGKIAFLPFQLERCFAQDGTEQYLVARTVAGFTGLAVGAEVTHWNGTPIARAVAL
                     NGAVFAGSNTAANLARGLESLTLRPLVIQLPPDEDWVVVSHRTEAGAAEEVRVDWQVTE
                     NLPPMTDVDSLSPAAAAQGVDLDSDEKARAKKLLHAPKVVQAEAAGGAVAMAAQDVATT
                     MPGVFRARPVTTPSGTFGHLRIFTFSVDDPEAFLAEFVRLANLLPQNGLIVDVRDNGGG
                     HIFASEFLLQTMTPKRIAPEPVQFLSTPLNLRICRRHAEDPTGQIDLGPWFPSLDSSTE
                     TGQAFSCSHTITPVDGANAVGQTYHGPVVLITDARCYSATDIFAAGWADHELGPILGVD
                     DNTGAGGANVWTHGLLATLLKIPAPVDPESPYRPLPNKANMRVSIRRTLRVGKLAGTPV
                     EDLGVRPTHQHKVTRADLLQGNVDLLARAGELLKELPVRRLGVAVAGTTVSLDTVNLDR
                     VDVYVDGRPATSLDVTDGAHTATLNATGREVRVEGFADGQLVAARKVAS"
     gene            5455..7842
                     /locus_tag="ND450_RS18345"
                     /old_locus_tag="ND450_18345"
     CDS             5455..7842
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS18345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_18345"
                     /product="hypothetical protein"
                     /protein_id="WP_253327291.1"
                     /transl_table=11
                     /translation="MSPRVLELRIHGVNNTPPHAMLALSPDDVERFSGSDKLGSFWETK
                     PDRVAALPQGHPGQAPPGVRREAYSWGGMARSSPGIGGSGVPSRAVNLLGRIGWALLLP
                     FGLANVAYWSRKLPVDASPDKPQKVWWNSGRGAASTRLFGLGLTLLLVLAVCEVAIDVY
                     AVQCSLPAANCRRLPEFLDVLGDPPRHVRVLVASVVPVLLLLGLVALTSLSRSRYEAAQ
                     STPERHDGVMLGRSSMWQGDSRVGRLTRLHLAAGFSVVALVTSVQVPRAFFFGVTVAAA
                     AVLAVVIARVVVTAADGPDVPQSVGNGPWSRWLVVVAALVLVAHLAGIYVLAPAFDGPL
                     LLVQWGPPVVTAALLGSTLAAWSWRRNDKKGPLVFVVLFAAFMVAGHWSSWAWIGVVLV
                     GAAFLWRAWPRKGDGWQAWHGAGPGVLLGLSLTASVTLSTVLVLTFRGWVGAGLRASSF
                     YLWFGATFACVAVLLLVFLLVHAGFFMARWKKPSPFDGEGTSSVVRARHLAAVAHRAEN
                     VVGVLSTVSVLALVLTCYLSFASPAWARWSNITWVVNGSNWVIGLVGVAVVGAFIGAGT
                     LTNRRPLGLVWDLMCFLPRAAHPFAPPCYAERAVPELAEHTHSWLARSPENRVVLSAHS
                     LGAVLAVAAIYALPPEDLGRVRLLTYGVQLRPYFGRIFPELLGPPVLGTPQVRAGTFFS
                     LDPWWRPPGEPQEGGLSSLLGANWVNLWRRTDYLGFPVRSWTGGSADRRADETLEGAST
                     VETHSDYHRCAAYRKAFAELVPIDLNQSPDRGRGEDGNLERS"
     gene            7856..8437
                     /locus_tag="ND450_RS18350"
                     /old_locus_tag="ND450_18350"
     CDS             7856..8437
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006801 - superoxide metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018681156.1"
                     /locus_tag="ND450_RS18350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_18350"
                     /product="superoxide dismutase family protein"
                     /protein_id="WP_253327292.1"
                     /transl_table=11
                     /translation="MRTTVAALTGAVLLTAGLAACSASDGPAGSPSVKPIAETTVAAPA
                     ASGDQPAGITYDVARIPVGARLSTGSTVADGRTTVELKVSGLLPDTKYGSHVHTKPCGA
                     KPADSGPHYQNSKDPVSPSVDPRYANAENEIWLDFTTDAQGAASAEATVAWEFRKGEAN
                     AVVVHAAHTSTDHGKAGTAGDRLACLTATF"
     gene            complement(8446..9804)
                     /locus_tag="ND450_RS18355"
                     /old_locus_tag="ND450_18355"
     CDS             complement(8446..9804)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.5"
                     /locus_tag="ND450_RS18355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_18355"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_253327293.1"
                     /transl_table=11
                     /translation="MREFGELLRTHRIGAGLTQQQLADFAMVSVRAIRDLECGRTRSPR
                     AETVRLLADGLRLDEGSRADLQQAGGRSAGRAAVAPPAPAGPGGLIVGREAEAAALAAL
                     LTEAPGGAGGPGQAGVGPGQVRGAAEPGEARHRAGSAAGLGNAVRHIAAPGGTVADVIA
                     LGRADTLGRADTLGRADTLGRADTVGRADTLGRAATLRGPHAPTRLITITGVSGVGKTR
                     LALEVAGDLHFRHGWSVLWHPSHATPAVDDDQDTVLVTDHRPDPHLLDAHPRLRVIVTA
                     LAPTGLPGEHVFPLGALADDAAVRLLLTHVHRVRPAFKPEPANQAALVGLVHALDGLPS
                     ALEFAAGWFMVYSPQHLLERLRSHPLDPTSAHLRDSLRRSLSTMDDEARALLVRMAEGQ
                     EAGHGRALQELRVRGLVRRAGDRYEVLSLVRAAVLEPVSGPHLHGSVALTWPV"
     CDS             9837..10004
                     /gene="allorf_4179451_4179618"
                     /locus_tag="allorf_4179451_4179618"
                     /protein_id="allorf_4179451_4179618"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MIGRRDMGGGPPYSRPRAGPGGPRAGSGAAVAGGVRKSGGLIPMC
                     GAVARARLCR"
     CDS_motif       9837..9938
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MIGRRDMGGGPPYSRPRAGPGGPRAGSGAAVAGG"
                     /locus_tag="allorf_4179451_4179618_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9939..10004
                     /prepeptide="core"
                     /locus_tag="allorf_4179451_4179618_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.50"
                     /molecular_weight="2196.7"
                     /monoisotopic_mass="2195.2"
                     /core_sequence="VRKSGGLIPMCGAVARARLCR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MIGRRDMGGGPPYSRPRAGPGGPRAGSGAAVAGG"
                     /leader_location="[9836:9938](+)"
     gene            10001..12610
                     /locus_tag="ND450_RS18360"
                     /old_locus_tag="ND450_18360"
     CDS             10001..12610
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="ND450_RS18360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_18360"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_253327294.1"
                     /sec_met_domain="DUF4135 (E-value: 3.3e-104, bitscore:
                     348.1, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.3e-17, bitscore:
                     61.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSAAETSTGESWTAAFAHALRPLIDASRTEVAPPFDAAFAEQLG
                     RRLVEIAARTLVLELHTVRGTLTSATSEERFAEFTRTLNLSSVFNRYPVLARLLAQACE
                     QAVSTHHELSSRFTRDRAQIVRTIFDDHDPGALISIETGQGDAHQQGRTVAVLTFESGA
                     KLVYRPRPVGLHVRFQEQVRWLSERTRIDFRSPRLLPRDGYGWIEHVTHEPCADVSQVA
                     EFYRRLGALLALLYAVDGTDMHYENLIACGDQPVLVDVETLFHPTLVNDADPAAAALVR
                     SVHRTALLPHVLLGDNGVADVSGVGGDHGVLSPLNSVDWADPGTDRMRLVRRPRTSSGA
                     RNRPLLDGTPAEPADYQDSLLAGFRAGYDAIVAHRDELLRLVRECADEEVRFVARATRQ
                     YARLLDESTHPSVLADALDRDLAFGVLVVDDPLLDRLVPFEVSDLWRGDVPLFTCRPGS
                     TDLWTASGLRLPGMLPEPGLHAVTRKILAMSEVDRHDQQWVITALLASRPRPVSHHSGA
                     AVQGHVAPVDPDPARLLVAACGIADQILAHAVTGEDRVNWLGLELVDDRHWTVQPLGAG
                     LSNGYTGVALFLAELGALTGAARYVDFARDALRPLPDLLHLFAEQPELVSVVGGGIHGL
                     GGICYGLARLTPLLGLDPKLLAQAVQLMPREDSSHTVLDGVAGSLAAMLAVGTPESLAL
                     ADHYASTLRGVISSSNGFARGDAGIGWALRRYAATVRDELSDVAARTSLESDAIDPTDT
                     GWCTGLAGVALARDDERLAGLLASREPLRDMSLCHGELGVVEALAAHHPSAANRRTALL
                     LGTLDEQGARCATPGGVPSPGLLTGLSGIGHGLLRQGFPIPSVLLLQASPDEEECTR"
     misc_feature    12200..12202
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12607..12795
                     /locus_tag="ND450_RS18365"
                     /old_locus_tag="ND450_18365"
     CDS             12607..12795
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS18365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_18365"
                     /product="hypothetical protein"
                     /protein_id="WP_253327295.1"
                     /transl_table=11
                     /translation="MNESLHSAADRSDAAEHAIGEMELAPKTLAGARARALMGLTMATS
                     AFVAITPLVTDTTVSVV"
     gene            12865..15741
                     /locus_tag="ND450_RS18370"
                     /old_locus_tag="ND450_18370"
     CDS             12865..15741
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015804021.1"
                     /locus_tag="ND450_RS18370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_18370"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_253327296.1"
                     /transl_table=11
                     /translation="MQTGASQVIGRDQEVTAITGALSRTRDSRGGAVFLTGEAGIGKSR
                     LARYAAGAAFDEGMRVLKGRGTTIGPMVPFRPIAEALLGLFRGDPPDDSALGPYKPVLG
                     TLIPEWHDHRSTTESVVVLAEAVLRLLASVARKTPVLLVLEDLHEADAETLAVVEYLAD
                     NLEDQPVLLLATIRSEPGHALELVRRMVQRGSGALVELHRLSQDEVGQMTAACLESDRI
                     PPELVDRLWTDSAGNPFVVEELLHGMVSGGLLVAGAHGWQVLGELKLPVPAAFVRSVAH
                     RTDRLGPQGREVLSIAAVLGHRFPLSLVQKVTGVDDRELLSHLHAGVAAQLVTPDEPAP
                     DWYAFRHPLTADALLAQLTLAERVDLSARTADAIEDLHPGLPGDWCPLVAKLRLDAGAE
                     TEAGLLFAEAGRRALAGGAAESAVTLLDRAQGLLTGEAGLRADVLDTLLPALAETGEFE
                     RAFALDVADLQALDGPRRAKLHSRLSRVAFTAGWFTEGVEQVRIARTLLGPDAPDALTA
                     SLDVNLAHLTLNIPSPDRISSAEGLARRAAQAADRAQLPVEACEAWQLLGIIAREHDIN
                     EANACFGKALALADTHHMPIQHVYALVRLAGNDWLQHGDTTSLDRTHAEASRAGAIAVA
                     HNVDAILALQSVLTGDYAVAAEQIERCLQTTTRLRFHSLTRYLLMSKATLAAHQGNRAA
                     TDDAITEFEAVAKNGAQEYPLCFGLARAFCALLEENRTLAMTELDRALALESQNPTTFH
                     LSGTHGMRVLLGVLDGRFGWADHRALTTSSASGMRWNRQFTELAHAVLLGRDGRGDEAL
                     QAFQRAQEAAEPYPLARHLGLRLVAGDAASWGDPVAWLRSAEEYFHQRTIPAVASACRG
                     LLRQAGAPVQQRRSGTDQVPRQLRGQGVTVREFEVFVLLADRMGNKAIGTRLHISPRTV
                     EKHVASLIAKTGQPDRESLSAFAAEFGG"
     gene            complement(15690..15905)
                     /locus_tag="ND450_RS18375"
                     /old_locus_tag="ND450_18375"
     CDS             complement(15690..15905)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226142.1"
                     /locus_tag="ND450_RS18375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_18375"
                     /product="CDGSH iron-sulfur domain-containing protein"
                     /protein_id="WP_253327297.1"
                     /transl_table=11
                     /translation="MLVEGPVELVTDDGVTHTSDRFVVAVCACRRSKRFPFCDTSHRKR
                     VRDDPPDGAGQPPNSAAKAESDSRSG"
     gene            complement(15895..16590)
                     /locus_tag="ND450_RS18380"
                     /old_locus_tag="ND450_18380"
     CDS             complement(15895..16590)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007024877.1"
                     /locus_tag="ND450_RS18380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_18380"
                     /product="HemK2/MTQ2 family protein methyltransferase"
                     /protein_id="WP_253327298.1"
                     /transl_table=11
                     /translation="MRLLRAPGVYTPQHDTALLVEALHAAAIAPGGRVLDIGTGTGALA
                     IAAIRAGAAEVTGVDVSRRAVWTARVNAALQRVPLRVRLGNALDVVADESFDLVLSNPP
                     YVPAASTCAAKGPARAWDAGIDGRQLLDPLCARIHDLLVPGGVLLMVHSALCGVDTTLQ
                     RLRDCGLKAAVVQRRWVPFGPVMNGRIGFLEQHGLIEPGQRHEELVVIRGDRPERPQGD
                     GGAERADAR"
     misc_feature    complement(16607..16622)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.87"
                     /tool="antismash"
     misc_feature    16633..16648
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.35"
                     /tool="antismash"
     gene            complement(16752..17228)
                     /locus_tag="ND450_RS18385"
                     /old_locus_tag="ND450_18385"
     CDS             complement(16752..17228)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226138.1"
                     /locus_tag="ND450_RS18385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_18385"
                     /product="DUF1360 domain-containing protein"
                     /protein_id="WP_253327299.1"
                     /transl_table=11
                     /translation="MRKIWKAYGEGRPLPGYLLAIGSYAALAGAVSVAGRLTGVRLPER
                     FSLADTALVSVATHKASRLLTKEAVTSPIRAPFTRYEEPAGHAELKESVRSDHPAQHAI
                     GELLTCPFCAGVWIASGLSAGLVFAPRLTRFVSTALTAVAASDVLNLVYDKLKS"
     gene            complement(17225..17416)
                     /locus_tag="ND450_RS18390"
                     /old_locus_tag="ND450_18390"
     CDS             complement(17225..17416)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005455884.1"
                     /locus_tag="ND450_RS18390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_18390"
                     /product="DUF2795 domain-containing protein"
                     /protein_id="WP_253327300.1"
                     /transl_table=11
                     /translation="MSDQNPIEVQKYLSGVDYPVTRRQLVEKARENGASDDIVSALEKL
                     PDREYNGPNAVSAEVSKA"
     gene            complement(17433..18227)
                     /locus_tag="ND450_RS18395"
                     /old_locus_tag="ND450_18395"
     CDS             complement(17433..18227)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (4-170). E-value: 2.7e-15. Score:
                     48.7. Matches aSDomain:
                     nrpspksdomains_ND450_RS18395_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003063245.1"
                     /locus_tag="ND450_RS18395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_18395"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_253327301.1"
                     /transl_table=11
                     /translation="MNALAVVTGASSGIGYELAKVLADNAFDVVVVAEDERIDDAAAQL
                     RLRSGGVHVEPVRADLRGYEGVESVVARVRAMGRPVDVLAVNAGVGVGGDFVRDTSVDD
                     NLEIVDLNVRSAVHLSHRLIGDMVDRKEGKVLFTSSVAATAPGPFHAVYAASKAFLASF
                     AQGLREELRDTGVSVTTLMPGPTDTEFFDRAGMQDTKVATGDKDDPAQVAQQGFDALMK
                     GDDHVVAGSLKNKVQAIAGKVAPDPVKAKMTRSMTEPGSAES"
     aSDomain        complement(17718..18215)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ND450_RS18395_PKS_KR.1"
                     /evalue="2.70E-15"
                     /label="ND450_RS18395_PKS_KR.1"
                     /locus_tag="ND450_RS18395"
                     /protein_end="170"
                     /protein_start="4"
                     /score="48.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="AVVTGASSGIGYELAKVLADNAFDVVVVAEDERIDDAAAQLRLRS
                     GGVHVEPVRADLRGYEGVESVVARVRAMGRPVDVLAVNAGVGVGGDFVRDTSVDDNLEI
                     VDLNVRSAVHLSHRLIGDMVDRKEGKVLFTSSVAATAPGPFHAVYAASKAFLASFAQGL
                     REE"
     CDS_motif       complement(17733..17822)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ND450_RS18395_0001"
                     /evalue="1.10E-04"
                     /label="PKSI-KR_m4"
                     /locus_tag="ND450_RS18395"
                     /protein_end="165"
                     /protein_start="135"
                     /score="14.7"
                     /tool="antismash"
                     /translation="LFTSSVAATAPGPFHAVYAASKAFLASFAQ"
     gene            18368..19360
                     /locus_tag="ND450_RS18400"
                     /old_locus_tag="ND450_18400"
     CDS             18368..19360
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099845.1"
                     /locus_tag="ND450_RS18400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_18400"
                     /product="efflux RND transporter periplasmic adaptor
                     subunit"
                     /protein_id="WP_253327302.1"
                     /transl_table=11
                     /translation="MRKILLAPLCALVTVGVAACSPSGPDQANPELAPRGTTMTKVKPT
                     RQDLTTKLSIAGKVEMNPTFGLVAPVAGQVRYFDVPAPNGTPTKPIRVATVWKDQTPNY
                     VEAPAGSTFSGRLVDDKATVTAGMPIASAKHVGYALVGDIDGQQAYKISGALTDVTAQI
                     KNGPGPFPCTVLGTIAALPQGTIPEKPPVTQDNKDGEKKDQPQQQPQQQQQQQPSSSTG
                     LRIVCSAPPDVQMINGATASIEVTTGKAAQALVVPVEAVAGQQGKGKVDVIQPDGSRRT
                     TDVVLGLTDGKVVEVKSGLTGDEELAVPGPNLPEGQQQGGGQQQKPTGP"
     gene            19360..20070
                     /locus_tag="ND450_RS18405"
                     /old_locus_tag="ND450_18405"
     CDS             19360..20070
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018682143.1"
                     /locus_tag="ND450_RS18405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_18405"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_089926131.1"
                     /transl_table=11
                     /translation="MTQTFDQPTVQVQAPLLQLNGITKVLKGQGEPRTILSGVDFTVHA
                     GQSVAILGRSGSGKSTLLSLIGLFDRADEGQYLLHGDDITKLPERRAAALRSAEFGFVF
                     QRFFLLKHLTAAQNVAMALVNGQGWSARRKRRQQVMDALEQVGIAHLAKSKPTRLSGGE
                     QQRVAIARALVRQPRIILADEPTGALDTETGNLVVEVLLNTTRQGCGLVLVTHDHDHAR
                     KMGRVLELRDGRFN"
     gene            20070..21398
                     /locus_tag="ND450_RS18410"
                     /old_locus_tag="ND450_18410"
     CDS             20070..21398
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099752.1"
                     /locus_tag="ND450_RS18410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_18410"
                     /product="ABC transporter permease"
                     /protein_id="WP_253327303.1"
                     /transl_table=11
                     /translation="MLSGKFRSALVIGGQGIRARKLRTFLSMVSLFLGVLAVVAVQAGA
                     EIAERAMLTDVELQSGKDGTVTGYVPGEKGAPGIVEAMMKGRTDAVAMIGSKAIIGEPG
                     VRPINEGGMPFEYAGRGGDYSGPQVYCDANGTCTEQKAQEKKPDGQAIEVSMVALTGDI
                     RPFKPFRPVSGSWLEFDTAPSLAPRIVLNEEAAKGLRQYRVPGEMMIDGATHHVSPQIT
                     GVVQDGYLQPRIYMRLDELRTWMPAAAETSEIDRMRGGGTNLELYLQPGSDELQQLLKA
                     KLAGVGIPQDQMHFQVVKSKERMESELRIMRLIFLGMAFLVLLIGVAGILNVGLATVGE
                     RVEEFALRRAVGMSRMLLAGIVLAETLLTGLLTAALAIGAGAAGLQVALMMFGSRFPSL
                     QGTAFPWEAGVAGVIAGLIAGVLGGLIPAIRAARIPIATVMRA"
     gene            complement(21509..22294)
                     /locus_tag="ND450_RS18415"
                     /old_locus_tag="ND450_18415"
     CDS             complement(21509..22294)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020645586.1"
                     /locus_tag="ND450_RS18415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_18415"
                     /product="aldo/keto reductase"
                     /protein_id="WP_089926427.1"
                     /transl_table=11
                     /translation="MPQLGFGVWQVPDAEATPAVAEALKAGYRSIDTAAAYGNEAGTGA
                     AIAQSGVARDEVFVTTKLWNDDHGHDNTLRAFDASMSKLGLDVLDLYLIHWPTPARDNY
                     VDTWKAFVELQKEGRVRAIGVSNFQPAHLQRLIDETGVTPAVNQIELHPYFQQADLRAF
                     HAEHGIVTEAWSPLGQGGELLTDPVVQKIALAHGKSAAQVVLRWHLQLGNVVIPKSVTP
                     SRIRENIDVFDFELPDAEVEALSTLDRGGRIGPNPDELN"
ORIGIN
        1 cgagttcttc agccggtagg cggtgccgtc cggcgcgacc aggtcgatca ccaggtcgcc
       61 gcggtaggtg tggacgatgt ccacacctac cttggtggtg gcggaggcgt tgcccgtcac
      121 cgtggagttg atggaggacg tgacggcggt gccgcggtcc gggatggcca cgtcggtcgt
      181 gttctccagg ccgccggagg gcggcggggt ggtgtcgacg gcgttcacgg tcttggtggc
      241 gtccgcgagg cccgcgccgc agccgcccga gcaggtgccg gggaaggtgc gggcgttggt
      301 cttgatcagg tccttgacct cggccggggt gagcgacggc ttcttggcga cgagcagtgc
      361 cgcgaggccc gcgatgtgcg gggccgccat cgaggtgccc tggtagggct tgtagttctc
      421 ggcgccgggg gtggtggcgc cggcgttcag cgtcgaccag atgccgttct ccggcgtggt
      481 gatggtgccg ggggtgtcgg tgcctcggcg ggtctcgccg ccgggggccg cgatgtcgat
      541 gcgggtgccg aagttcgagt agaacgcctt gttgccttca cgcgaggagg ccgcgacggt
      601 gatgacgccg ttgcagttgg ccggggtgaa gttcgcgacg ttcatgttcg agttgcccgc
      661 cgcgacgacg accgtggtgc cgcggttgat ggcgccgttg atcgcgttct ggtacgtcgt
      721 ggagcaggag gactggccgc ccagggacat gttgatgacc ttggcgacgt tctggttcgc
      781 gggcacgccg ctcaccgtgc cgccggacgc ccaggtgatc gcgtcggcga tgtccgaggt
      841 ggcgccgccg cacttggcga gaacgcgcag gggctggatc ttcgcgtcgt aggcgatgcc
      901 cgcgatgccc ttgctgttgt tcgtggccgc ggcgatggtg ccggcgacgt gcgtgccgtg
      961 ccaggacgag ccctggtcgg cggccgggac cgggttgccg ttggcgtcgg tgccgcactc
     1021 gccgcgggcg acccagtcac cctcgtcggc cgggttcgag tcacggccgt tgttgtcccg
     1081 tgcgcgcgcc gagtcggaaa cgaagtcgta ccccgcgacg accttgctcg ccaggtcgct
     1141 gtgcgcgacg tacccggtgt cgatcacggc gacggtgacg cccgcgccgg tggtgctgga
     1201 ccaggcgccg ggcacgttca tgcccgcggt ggcctcgaag aggtcccact gcctggagta
     1261 ctcggtgtcg ttcgggtcgg cgaacggctg catcagcagg tccggctcga cgtaggcgac
     1321 cttcgggtcg ttcttgaacg cctggatggt gctgtcggcg ttcgtggtct tggagccgag
     1381 gtcgacgacg acagcgccac tcgccgtgcg gcggtgcagc gacttgccct tcttgcgggc
     1441 gtcgtccgag gcagcggtgt cggacgaggc ctcggcggtg ccgggcttgt agccgacgat
     1501 cagccgctcg aagggacggt tcacctgggt cgagtccggc tgggactgga tctgggcggg
     1561 ggcagcggtc gccgaggggg cgacaacgct gagcacggcg gcggaaactg ccgcggcgca
     1621 cacactcgtg cgtcgcatct tgttcacgtg aggtccttcc acgcagggcc ttcgcgtgcc
     1681 gttgagggcg tcagggttct gaaccggctg cggaggtgga gggaccgtaa gtcgggtcac
     1741 acctgcgaaa acaggtctag cggagtccga tttccgacac tgtcgtgttc acgacacggg
     1801 tgttgcgctg aatggcgcac aatgtggccg tgttcggaca cttgggcgtc gcaccggagc
     1861 tcaccgccgt ttacgagctc ctggtaacgg gcggaagccg cacgacggac gaaatcggcg
     1921 tcaacgcctc gctgctggag cggatgcggg agttcggcct ggtccggcac ctgcccgggg
     1981 acgtgtggca ggccgtcgca cccgacctgg ccgtggaggc gttgatcgcg gcccgcgagg
     2041 agcagaaccg ccgggcccgc gcggacgtcg gcccgctgat ggagctctac ctgcgcaacc
     2101 gcggcgagga gctggcggac aacgcgttcg tcgaggtggt gtccggtgtg gacgccgtgc
     2161 gcgagctgtg gcacgccctg ctccgcggcg cccgcgacga ggtctgcgtg ctcgaccagc
     2221 ctccgtacgt gacgccgctc ggccagcacg tcgcgctcga ggacgagacg cgcgaacggg
     2281 acgtgcagtg gcgcgtcgtc tacgaccgct cggccgtcga catccccggc cgggtcacgg
     2341 agatcatcga actggtcgcg gcgggcgaac gcgcccgtgt cacgccgacg ctgccgttca
     2401 agctcgcggt gatcgacacg cacgcggccg tgctccccgt cgtcaacggc gacgtggtcg
     2461 acaaggtgct gctgatccgc ccgtccgcgt tgctcgacgt gctgcggtcg acgttcgagc
     2521 tgtactggga caaggggatc ccgttcagcc ccggcggcat ctacgcggcc gcggccgacg
     2581 tcgacccgaa cctgctgggg ctgctggccg ccgggctgac cgacgagtcg atcgcgcggc
     2641 agctggggct cgcgccgcgg accgtgcagc ggcgggtgcg gcagctgatg gaccggtgcg
     2701 gggcgcagac gcggttccag gccggtgttc aagcgatgcg ccgaggttgg ctctaggcgg
     2761 catgcaaccc cagggtgatc ttgtggcgtc ttacccacag caagcaagta ctcaccaggg
     2821 ggattaaaaa atgcgcatgc tcaaggtgat ggcggccgcc ctgacgggcc tggcactcat
     2881 cggtatcacg ggtacggcgt cggcgtccgc ggacgtcgtg tggccgccga aggacgtcac
     2941 gccgatccac aagaccaagg cggagctgga ggtgcaggcc gccgggttca ccgctcgtca
     3001 gcaggagacc ttcccgaagg tcttccgcgg cgcggagaac gtctcgcccg gcaactgggg
     3061 tggtgaggcg gagggccgtc tgttcgacga catgcagtac atgacgaact ggaccggctt
     3121 caccgtgcag ggccagagca acacggtgtt catgcaggtc aacgcgccgg ggttcttcca
     3181 ggagtcgccg cagcagctgt gtgagcggga caggtgcacc ggcaaggtca gcgaccaccg
     3241 cggtggcgtc acggtcttca ccaagaacga ccagcacggc atcacgatcg cgtggaactt
     3301 ccgccgcaac ggtgaggtcg tctgggcgca gagctggacg gcgggtacgg aggcgcagct
     3361 cgcggcagtg gcctccgacc gcgcgtacac gttcacgcgc tagcacgtga gggtgcgggc
     3421 gcaaccggtc atggagtcac cggaagcgcc cgcccgatca actggcgacc ttgcgcgcgg
     3481 ccaccagctg cccgtccgcg aacccctcga cgcgcacctc gcgcccggtc gcgttcaacg
     3541 tcgcggtgtg cgcgccgtcg gtcacgtcca gcgaggtcgc cgggcggccg tcgacgtaga
     3601 cgtccacccg gtcgaggttc acggtgtcca gtgagacggt cgtgcccgcg accgccaccc
     3661 cgagccgccg caccggcagc tccttcaaga gctcccccgc ccgtgcgagc agatccacgt
     3721 tgccctgcaa cagatccgcg cgcgtgacct tgtgctggtg cgtcgggcgc acgccgaggt
     3781 cctccacggg cgtgcccgcc agcttgccga cgcgcaacgt gcggcggatc gacacgcgca
     3841 tgttcgcctt gttgggcaac ggccggtacg gcgactccgg gtccaccggc gccgggatct
     3901 tcagcagggt cgccagcagt ccgtgcgtcc acacgttcgc gccacccgcg ccggtgttgt
     3961 cgtccacgcc aaggatcggg cccagctcgt ggtcggccca gcccgcggcg aagatgtccg
     4021 tggccgagta gcagcgcgcg tcggtgatca gcacgaccgg gccgtggtag gtctggccca
     4081 cggcgttcgc gccgtcgacc ggcgtgatgg tgtgcgagca ggagaacgcc tggcccgtct
     4141 cggtcgagct gtcgagcgac gggaaccacg ggccgaggtc gatctggccg gtcgggtcct
     4201 ccgcgtggcg gcggcagatc ctcaggttga gcggcgtgct caggaactgc acgggttccg
     4261 gcgcgatccg cttcggcgtc atcgtctgca gcaggaactc cgaggcgaag atgtggccgc
     4321 cgccgttgtc gcggacgtcg acgatgagtc cgttctgcgg caacaggttc gcgagccgga
     4381 cgaactcggc gaggaacgcc tccgggtcgt cgacgctgaa ggtgaagatc cgcaggtgcc
     4441 cgaacgtgcc ggacggcgtg gtaacgggac gcgcccggaa cacgccgggc atcgtcgtcg
     4501 cgacgtcctg cgcggccatc gcgaccgcgc cgccggccgc ctcggcctgc acgactttgg
     4561 gcgcgtgcaa caacttcttg gcgcgtgcct tctcgtccga gtcgaggtcg actccctgtg
     4621 cggcggcggc cggtgacagc gagtccacgt ccgtcatcgg cggcaggttc tcggtcacct
     4681 gccagtcgac gcggacctcc tcggcggcac ccgcctcggt gcggtggctg acgacgaccc
     4741 agtcctcgtc gggcgggagc tggatcacca aggggcgcaa cgtgagcgac tcgaggccgc
     4801 gggcgaggtt cgcggcggtg ttgctgcccg cgaacaccgc gccgttcagc gcgacggcac
     4861 gggcgatcgg cgtgccgttc cagtgcgtca cctcggcgcc gaccgccagg ccggtgaaac
     4921 ctgcgaccgt gcgggcgacg aggtactgct cggtgccgtc ctgcgcgaag cagcgctcca
     4981 gctggaacgg caagaaggcg atcttgcccg cgaacggcgc gggcagcagg tagttcgtgt
     5041 gcaggtcgcg caccgagtgg aaggtgctcg acagctcgcg gtggaactgc cactcggcct
     5101 cggccgtcgc gtcggtctgc cgttcgagtc tcgctctgag aactctgagc cgctgcacgg
     5161 ggttcacggc gtgcatggcg actttcagag gcaggtgcgc gtagttctgc tccagcagga
     5221 tcaacgcctg gtcgacgatg agcttgcgct gcgccagggt gagcgtgccc gcggtggcga
     5281 ggaactcggc gagtccgacg gagttcgcga tgttcgggtg agcggttgcg gtcatggtgg
     5341 ggcctccttg ctcagtagag gcttccgagg gcacctggat acaccttttt cacccgttcg
     5401 gccgctaact ggagcagttc ccgggacgac aactggagta gagggaggcg cgccatgagt
     5461 ccacgtgtcc tcgaactgcg catccacggg gtgaacaaca cgcccccgca cgcgatgctg
     5521 gccctgtcac cggacgacgt cgagcggttc agcggctctg acaagctcgg cagcttctgg
     5581 gagacgaaac cggaccgggt ggccgcgctg ccccagggac accccggtca ggccccgccc
     5641 ggcgtgcggc gcgaggccta ctcgtggggc gggatggcgc gcagcagtcc ggggatcggc
     5701 ggcagcgggg ttccgtccag ggccgtgaac ctgctgggcc gcatcggatg ggcgctgctg
     5761 ctgccgttcg ggctcgcgaa cgtcgcctac tggtcccgga aactgcccgt cgacgcgtcg
     5821 ccggacaagc cgcagaaggt gtggtggaac tccgggcgcg gcgcggccag cacgcgcctg
     5881 ttcgggctgg ggctcacgtt gctgctggtg ctcgccgtgt gcgaggtcgc gatcgacgtc
     5941 tacgcggtcc agtgctcgct gcccgcggcg aactgccggc ggctccccga gttcctcgac
     6001 gtgctcgggg acccgccgcg gcacgtccgg gtgctcgtcg cctccgtcgt gccggtgctg
     6061 ctgctcctcg gtctggtggc gctcacctcg ttgtcccgca gcaggtacga ggcggcgcag
     6121 agcacgccgg aacgccatga cggggtgatg ctcggccggt cgtcgatgtg gcagggcgac
     6181 tcgcgggtcg gccggctcac ccggctgcac ctcgcggcgg ggttctcggt ggtggcgctg
     6241 gtgacgagcg tccaggtgcc gcgggcgttc ttcttcggcg tcaccgtcgc cgctgccgcg
     6301 gtgctcgccg tcgtcatcgc gcgggtggtc gtgacggcgg cggacggacc ggacgtgccg
     6361 cagtcggtcg ggaacggtcc gtggtcgcgc tggctggtgg tcgtggcggc actcgtgctg
     6421 gtggcgcacc tggccgggat ctacgtcctc gcacccgcgt tcgacggccc gctgctgctc
     6481 gtgcagtggg gaccaccggt cgtcaccgcg gcgttgctcg ggtcgacgct ggcggcgtgg
     6541 tcgtggcggc gcaacgacaa gaagggcccg ctcgtgttcg tggtgctgtt cgccgcgttc
     6601 atggttgcgg ggcattggtc ctcgtgggcg tggatcggcg ttgtcctggt gggcgccgcc
     6661 ttcctgtgga gggcgtggcc gcggaagggc gacgggtggc aggcgtggca cggcgcggga
     6721 cccggtgtgc tgctcgggtt gtcgctgacg gcgtcggtga cgttgtcgac cgtgctggtg
     6781 ctgacgttcc gcggctgggt cggcgcgggg ctgcgggcgt cgtcgttcta cctgtggttc
     6841 ggcgcgacct tcgcctgtgt cgcggtcctg ctgctggtgt tcttgttggt gcacgccgga
     6901 ttcttcatgg cgcgctggaa gaagccgtca cccttcgacg gtgagggcac gtcgtcggtg
     6961 gtgcgggcgc ggcacctcgc cgccgtggcc caccgcgccg agaacgtcgt cggcgtgctg
     7021 tcgacggtca gcgtgctcgc tctcgtgctg acgtgttacc tctctttcgc gtcacccgcg
     7081 tgggcccggt ggtcgaacat cacgtgggtg gtgaacggga gcaactgggt catcggtctc
     7141 gtgggagtgg ctgtggtcgg ggcgttcatc ggggccggca cgctcaccaa ccgccggccg
     7201 ctcgggctgg tgtgggacct gatgtgcttc ctgccgcgcg cggcgcaccc gttcgcgccg
     7261 ccctgctacg cggagcgcgc ggtgccagaa ctcgccgagc acacccactc gtggctggcg
     7321 cggtcgccgg agaaccgcgt ggtgctctcg gcgcacagcc tcggcgcggt gctcgccgtg
     7381 gcggcgatct acgcgttgcc gccggaggat ctggggcgcg tgcggctgct gacgtacggc
     7441 gtgcagctgc ggccctactt cgggcggatc ttcccggagc tgctcggccc gccggtgctc
     7501 ggcaccccgc aggtgcgcgc gggcacgttc ttcagcctcg acccctggtg gcggccgccg
     7561 ggcgagccgc aggagggcgg gctgtcgtcg ttgctgggcg cgaactgggt gaacctgtgg
     7621 cgccggaccg actacctcgg gttcccggtg cggagctgga cgggcggttc cgccgaccgc
     7681 cgcgcggacg agaccctgga gggcgcgtcc acagtggaga cccacagcga ctaccaccgg
     7741 tgcgcggcct accggaaggc gttcgcggag ctcgtcccga tcgatctgaa ccagtcaccc
     7801 gatcgtggac gtggagagga tgggaacctg gaacgcagtt gacacgagga gaaacatgcg
     7861 cacgactgtg gcggccctca cgggcgccgt gctcctgacc gcgggactgg ccgcctgctc
     7921 ggcatccgac ggcccggccg gctcgccttc cgtgaagccg atcgccgaga cgaccgtggc
     7981 cgcgcccgcc gcgtcgggtg accagcccgc cggcatcacc tacgacgtgg cgcgaatccc
     8041 cgtgggagct cgtctttcca ccggttcgac cgtcgcggat ggacggacga ccgtggagct
     8101 gaaggtgtcc ggtctcctgc cggacacgaa gtacggctcg cacgtgcaca cgaagccgtg
     8161 cggcgcgaag ccggccgact cgggcccgca ctaccagaac tcgaaggacc cggtgtctcc
     8221 gagcgtcgac ccccgctacg ccaacgcgga gaacgagatt tggctggact tcaccaccga
     8281 cgcgcagggc gccgcgtcgg ccgaggccac cgtggcgtgg gagttccgca agggcgaggc
     8341 gaacgccgtc gtcgtgcacg ccgcgcacac cagcacggac cacggcaagg cgggcaccgc
     8401 gggcgaccgc ctggcgtgcc tgaccgccac cttctagccg cgctgtcaga ccggccaggt
     8461 cagggccacg cttccgtgca ggtgcggccc tgacacgggc tccagcacag cagcgcgcac
     8521 gagactcagc acctcgtacc ggtctccggc acgccggacg agcccgcgca cgcgcagttc
     8581 ctggagcgca cggccgtgcc cggcctcctg tccctccgcc atcctgacga gcagcgcgcg
     8641 ggcctcgtca tccattgtgg acagcgagcg ccgcagcgag tcgcgcaggt gcgccgacgt
     8701 cgggtcgagg gggtgcgacc gcaaccgctc gagcaggtgt tgcggcgagt agaccatgaa
     8761 ccaccccgcg gcgaactcca gcgccgacgg caacccgtcc agcgcgtgca cgagtcccac
     8821 gagcgcggcc tggttggcgg gctcgggctt gaacgcgggc cgcacccggt gcacgtgcgt
     8881 gagcaacagc cgcaccgcgg cgtcgtcggc cagcgccccc agcgggaaca cgtgctcacc
     8941 gggcaacccg gtcggcgcca gcgccgtgac gatcacccgc agccgcgggt gcgcgtccag
     9001 cagatgcggg tcggggcggt ggtcggtgac gaggacggtg tcctggtcgt cgtcgacggc
     9061 aggggtggcg tgcgacgggt gccacagcac ggaccagccg tgccggaagt ggaggtcgcc
     9121 cgcgacctcg agggcgagcc tcgtcttgcc gacgccgctg accccggtga tggtgatgag
     9181 gcgcgtcggg gcgtgcggcc cgcggagggt ggcggcccgg ccgagggtgt cggcccgacc
     9241 aacagtgtcg gcccggccga gggtgtcggc ccggccgagg gtgtcggcgc ggccgagggt
     9301 gtcggcgcgg ccgagcgcga tgacgtccgc aacggtgccg cctggtgcgg cgatgtgccg
     9361 cacggcgttc cccagcccgg cagcgctccc ggctcgatgc cgcgcctccc ccggctcggc
     9421 agcacccctc acctgccccg gcccgacccc ggcctggccc ggcccgccgg caccgcccgg
     9481 cgcctccgtc agcaacgccg ccaaagccgc cgcctccgcc tcccgcccca cgatcagccc
     9541 accgggcccg gccggcgcgg gtggtgccac cgccgcacga ccggccgacc gcccccctgc
     9601 ctgctgcagg tcggcgcggc tgccctcgtc cagccgcagg ccgtcggcga gcaggcgcac
     9661 cgtttccgca cgtggcgagc gggtgcggcc gcactccagg tcccggatcg cccgcacgct
     9721 caccatcgcg aagtcagcca gctgttgctg ggtgaggccc gcgccgatgc ggtgcgtgcg
     9781 cagcagttct ccgaactccc tcatcccgtt ccctccctcg gacttcgagt ctcggggtga
     9841 tcgggcggcg ggacatgggt ggcggacccc catattcacg gccgcgagca ggcccgggcg
     9901 ggccgcgggc gggctcggga gcagcggtgg ccgggggcgt tcgcaaatct ggggggttga
     9961 tccccatgtg cggggcggtc gcgcgtgcga ggttgtgccg gtgacctccg cggccgagac
    10021 cagcaccggc gagagctgga cagcagcttt cgcccacgcc ctgcgcccgc tgatcgacgc
    10081 ctcgcgcacc gaggtggcgc cgccgttcga cgcggcgttc gccgagcagc tcgggcgccg
    10141 gttggtggag atcgcggcgc ggacgctcgt gctcgagctg cacaccgtgc gcggcacgct
    10201 gacgagcgcg accagtgagg agcggttcgc cgagttcacg cggacgctga acctctcgag
    10261 cgtcttcaac cgctacccgg tgctcgcccg gctgctcgcg caggcctgtg agcaggccgt
    10321 ttccactcac cacgagctgt cgtcgcggtt cacccgcgac cgcgcccaga tcgtccgcac
    10381 gatcttcgac gaccacgacc ccggcgcgct gatctccatc gagacggggc agggcgacgc
    10441 gcaccagcag gggcggaccg tggcggtcct gaccttcgag tccggcgcga agctcgtcta
    10501 ccggccgcgg ccggtcgggc tgcacgtgcg cttccaggag caggtccggt ggctgtccga
    10561 gcggaccagg atcgacttca ggtcgccgag gctgctgccc cgcgacggct acgggtggat
    10621 cgagcacgtc acccacgagc cgtgcgcgga cgtgtcgcag gtcgccgagt tctaccggcg
    10681 gctcggcgcg ctgctggcgc tgctctacgc ggtcgacggc accgacatgc actacgagaa
    10741 cctcatcgcg tgcggtgacc agccggttct cgtggacgtc gagacgctgt tccacccgac
    10801 gctcgtgaac gacgccgacc ccgccgcggc cgcgctggtg cggtcggtgc accgcacggc
    10861 cctgctcccc cacgtgctgc tcggtgacaa cggggtggcg gacgtgtccg gtgtcggcgg
    10921 cgaccacggc gtgctgtcgc cgttgaactc ggtcgactgg gccgacccgg gcaccgacag
    10981 gatgcggctg gtcaggcgcc cgcggacgtc gtcgggggcg cgcaaccggc cgctgctcga
    11041 cggcacgccc gccgagcccg ccgactacca ggactcgctg ctcgccgggt tccgcgcggg
    11101 ctacgacgcg atcgtggcgc accgcgacga gctgctgcgg ctcgtccggg agtgcgccga
    11161 cgaggaagtg cggttcgtgg cgcgggcgac gcggcagtac gcgcggctgc tcgacgagtc
    11221 gacgcacccg tccgtgctgg ccgacgcgct cgaccgcgac ctggcgttcg gcgtgctggt
    11281 ggtggacgac ccgctgctcg accggctggt gccgttcgag gtgtccgacc tgtggcgcgg
    11341 ggacgtgccg ctgttcacgt gccggccggg gtcgaccgac ctgtggaccg cgtccgggct
    11401 ccggctgccg gggatgctgc cggagcccgg gctgcacgcc gtcacgcgca agatcctcgc
    11461 gatgagcgag gtcgaccggc acgaccagca gtgggtgatc acggccctgc tggcgtcgcg
    11521 gccgcgcccg gtgtcgcacc acagcggcgc cgcggtgcag gggcacgtgg cgccggtcga
    11581 ccccgacccg gcgcggctgc tcgtcgccgc ctgcgggatc gccgaccaga tcctcgcgca
    11641 cgcggtcacc ggggaggacc gcgtcaactg gctcgggctc gaactggtcg acgaccggca
    11701 ctggacggtg cagccgctcg gcgccggcct gtcgaacggc tacacgggcg tggcgctgtt
    11761 cctcgccgag ctgggcgcgc tcaccggggc cgcgcgctac gtcgacttcg cgcgggacgc
    11821 gctgcggccg ttgcccgacc tgctgcacct cttcgccgag cagcccgagc tcgtctcggt
    11881 ggtcggcggc gggatccacg gcctgggtgg catctgctac ggcctcgcgc gcctcacgcc
    11941 gttgctcggc ctcgacccga agctgctcgc gcaggccgtt cagctgatgc cgagggagga
    12001 ttcgtcgcac accgtcctgg acggcgtcgc gggctcactg gccgcgatgc tcgccgtggg
    12061 cactcccgaa tccctcgcgc tcgccgatca ctacgcgtcc actctgcgtg gagtcatcag
    12121 ttcctcgaat ggtttcgccc gtggcgatgc gggaatcgga tgggccctga ggcgttacgc
    12181 ggcaacggtt cgtgacgagt tatcagatgt ggccgcacga acgtccctgg agagcgacgc
    12241 gatcgacccc accgacaccg ggtggtgcac gggactggcc ggtgtggcgc tcgccaggga
    12301 cgacgagcgc ctggccggtc tgctcgcctc cagggaaccg ttgcgggaca tgagtctctg
    12361 ccacggcgaa ctgggcgtcg tcgaggcatt ggccgcgcac cacccgagcg ccgcgaaccg
    12421 gcgcacggcc ctgttgctgg gaacgctcga cgaacagggc gcgcgctgcg ccaccccggg
    12481 cggcgtgccg tcgcccggcc tgctcaccgg cctgtccgga atcggtcacg gcctgctgcg
    12541 ccaagggttc ccgatcccct cggtcctgct actgcaagca tcacctgacg aagaggagtg
    12601 cacccgatga acgagtccct gcacagcgcg gccgaccggt ccgacgccgc cgagcacgcg
    12661 atcggcgaga tggaactggc gccgaagacg ctggcgggtg cgcgggcgcg tgcgttgatg
    12721 ggcctgacca tggcgacgag cgcgttcgtg gccatcaccc ccctcgtcac ggacacgacc
    12781 gtgagcgtgg tctaggaaac tttcacctcg aatacgtctg gccggtcgat ttcgagaccg
    12841 gtacgggccc gttagggtcc agacatgcag acaggagcgt cccaggtgat cggtcgtgat
    12901 caggaagtca cggcaatcac cggggcgctc tcccgcacgc gcgactcccg cggcggcgcc
    12961 gtcttcctca ccggtgaggc ggggatcggc aagtcgaggc tcgcccggta cgcggcgggc
    13021 gcggcgttcg acgagggcat gcgggtgctc aagggacgcg gcacgacgat cggcccgatg
    13081 gtgccgttcc gcccgatcgc ggaggcgttg ctgggcctct tccgcggtga tccgccggac
    13141 gactccgcgc tcgggccgta caaacccgtg ctgggcacgc tgatcccgga gtggcacgac
    13201 caccggtcga ccacggagtc ggtcgtggtg ctggcggagg cggtgctcag gctcctcgcc
    13261 tccgtcgcgc gcaagacccc ggtgctgctc gtgctcgagg acctgcacga ggcggacgcg
    13321 gaaacgcttg cggtcgtgga gtacctggcg gacaacctgg aggaccagcc ggtcctgctg
    13381 ctcgcgacga tccgcagcga acccggccac gcgctggagc tcgtccgccg gatggtgcaa
    13441 cgcgggtccg gcgcgctggt ggagctgcac cggctgtcgc aggacgaggt cggccagatg
    13501 acggccgcct gcctggagag cgaccgcatc ccgccggagc tcgtcgatcg cctgtggacg
    13561 gacagcgccg gaaacccctt cgtggtcgag gaactgctgc acggcatggt gagcggcggc
    13621 ctgctggtgg ccggggcgca cggctggcag gtgctgggag agctcaagct cccggtgccg
    13681 gcggcgttcg tgcgcagcgt cgcgcaccgc acggacaggc tggggccgca gggccgcgag
    13741 gtgctgtcca tcgcggcggt gctgggccac cggttcccgc tctccctggt gcagaaggtg
    13801 accggcgtcg acgaccgcga gctcctgagc cacctgcacg cgggcgtggc cgcgcagctc
    13861 gtgacaccgg acgagcccgc gcccgactgg tacgcgttcc gccacccgct caccgcggac
    13921 gcgttgctcg cgcagctgac cctggccgaa cgcgtcgacc tgtcggcgcg caccgccgac
    13981 gcgatcgagg acctgcatcc gggactgccc ggcgactggt gcccgctcgt cgcgaagctg
    14041 cgcctggacg cgggagccga gaccgaggcg gggctcctct tcgccgaggc gggcaggcgc
    14101 gcgctcgcgg gcggcgccgc ggagtcggcc gtcacgctgc tcgaccgcgc gcagggcctg
    14161 ctcaccgggg aggccggcct gcgcgccgac gtcctcgaca cgctgctgcc cgcgctcgcc
    14221 gagacgggcg agttcgaacg cgccttcgcg ctcgacgtcg cggatctcca ggccctggac
    14281 ggaccacgcc gcgcgaagct ccactcgcga ctgtcccgcg tcgccttcac cgcggggtgg
    14341 ttcaccgagg gcgtcgagca ggtgcggatc gcgcggacgt tgctcggacc ggacgcaccc
    14401 gacgcgctga ccgcgtcgct cgacgtcaac ctggcccacc tgacgctgaa catcccgagc
    14461 cccgaccgga tctcgtcggc ggagggcctc gcccggcgcg ccgcccaggc ggcggaccgg
    14521 gcgcagctgc cggtggaggc gtgcgaggcg tggcagctgc tcggcatcat cgcgcgcgag
    14581 cacgacatca acgaggccaa cgcgtgcttc ggcaaggccc tcgcgctcgc ggacacgcac
    14641 cacatgccga tccagcacgt ctacgcgctg gtccgcctgg cgggcaacga ctggttgcag
    14701 cacggcgaca ccacctccct cgaccgcacg cacgccgagg cgtcccgggc gggcgcgatc
    14761 gcggtggcgc acaacgtcga cgcgatcctc gcgctgcagt ccgtgctgac cggtgactac
    14821 gccgtggcgg ccgaacagat cgagcggtgt ctgcagacca ccacgcgcct gcggttccac
    14881 tcgctgaccc ggtacctgtt gatgagcaag gcgacgctgg ccgcgcacca gggcaaccgg
    14941 gccgcgaccg acgacgccat cacggagttc gaggcggtcg cgaagaacgg ggcgcaggag
    15001 tacccgctgt gcttcgggct ggcccgcgcg ttctgcgcgt tgctggagga gaaccgcacc
    15061 ctggcgatga cggagctcga ccgcgcgctc gccctggagt cgcagaaccc caccacgttc
    15121 cacctgtccg gcacgcacgg catgcgggtg ctgctcggcg tgctcgacgg ccgcttcggg
    15181 tgggcggacc accgcgcgct caccacgtcg tccgcctcgg gcatgcggtg gaaccggcag
    15241 ttcaccgagc tggcgcatgc cgtcctgctc ggccgcgacg ggcgcgggga cgaggccctg
    15301 caggcgttcc agcgcgcgca ggaggccgcg gagccgtacc cgctggcacg ccacctcggt
    15361 ctgcggctgg tcgccgggga cgcggcgtcg tggggcgacc cggtggcgtg gctgcgctcc
    15421 gccgaggagt acttccacca gcgcacgatc ccggcggtgg cgtcggcgtg ccggggcctg
    15481 ctgcggcagg cgggcgctcc cgttcagcag cggcgcagcg gtaccgacca ggtgccgcgc
    15541 cagctgcgcg ggcagggcgt gacggtgcgc gagttcgagg tgttcgtgct gctggccgac
    15601 cgcatgggca acaaggcgat cggcacgcgt ctgcacatct ccccgcgcac ggtggagaag
    15661 cacgtcgcct cgctcatcgc gaagaccggt cagcccgacc gcgagtcgct ctccgccttc
    15721 gcggcggagt tcggcggctg acccgctccg tccggcgggt cgtcgcgcac gcgtttgcgg
    15781 tggctggtgt cgcagaaggg aaagcgtttg ctgcgccggc acgcgcacac cgcgaccacg
    15841 aaccggtcac tcgtgtgcgt cacgccgtcg tcggtgacga gctcgacggg cccctcaacg
    15901 agcatcggcc cgttcggcac caccgtcacc ctgcgggcgt tctggccggt cacctcggat
    15961 caccaccagt tcctcgtgcc gctggcccgg ctcgatcagg ccgtgctgtt ccaggaagcc
    16021 gatccggccg ttcatgaccg ggccgaacgg cacccagcgc cgttgcacga ccgccgcctt
    16081 caggccgcag tcgcgcaggc gttgcagcgt cgtgtccact ccgcacagtg ctgaatggac
    16141 catcagcagc acgccaccgg gcaccagcag gtcgtggatc ctggcgcaca acgggtccag
    16201 cagctggcgg ccgtcgatcc ccgcgtccca cgccctggcc ggtcccttgg cggcacaggt
    16261 gctcgcggcg ggcacgtacg gcgggttcga gagcaccagg tcgaagctct cgtctgccac
    16321 gacgtcgagc gcgttgccca gccggacccg caacggcacc ctctgcaggg cggcgttgac
    16381 gcgcgccgtc cacacggcac gcctcgagac gtcgaccccg gtcacctcgg cggcgccggc
    16441 gcggatcgcc gcgatggcga gcgcacccgt gccggtcccg atgtcgagca cacggccacc
    16501 gggcgcgatc gccgccgcgt gcagcgcttc gaccagaagc gcagtgtcgt gctggggcgt
    16561 gtacacgcct ggtgctctga gcagcctcac ggcgttggaa tcccccgcca aaagaccttg
    16621 aaacaccgtg ttttcagggg ttttcgacgg gtacacgagg atgtgctgac gaccgtcttc
    16681 cgccctgtgg agtgcggacg gcggcctgcg cgcgcaggcc taccggcgcg gcaggcgcgg
    16741 ccgccggggg gtcatgactt cagcttgtcg tacaccaggt tcagcacgtc cgacgcggcg
    16801 acggccgtca gcgcggtcga cacgaaccgc gtgagccgcg gcgcgaacac cagcccggcg
    16861 gagaggccgc tggcgatcca cacaccggcg cagaacgggc acgtcagcag ctcgccgatc
    16921 gcgtgctgcg ccgggtggtc cgagcgcacg gactccttga gctccgcgtg ccccgccggt
    16981 tcctcgtacc gggtgaacgg cgccctgatc gggctggtca ccgcctcctt ggtgagcagg
    17041 cggctcgctt tgtgcgtcgc cacggacacg agtgcggtgt ccgcgagcga gaaccgttcg
    17101 ggcaaccgga cacccgtgag gcgtcctgcc accgagacgg cgccggcaag ggccgcgtag
    17161 ctgccgatgg cgagcaggta gcctgggagc ggcctgccct cgccgtacgc cttccagatc
    17221 ttcctcacgc cttcgaaacc tccgcactga cggcgttcgg accgttgtac tcgcggtcgg
    17281 gcagcttctc cagcgccgac acgatgtcgt cggacgcgcc gttctcccgg gccttctcga
    17341 ccagttgccg cctggtcacc gggtagtcga caccggacag gtacttctgg acctcgatgg
    17401 ggttctgatc gctcatgggg cgcgaatacc cgtcaggact ccgccgaacc cggttccgtc
    17461 atcgaccgcg tcatcttcgc cttgacgggg tccggcgcga ccttgcccgc gatcgcctgc
    17521 accttgttct tcagcgatcc cgcgaccacg tggtcgtcgc ccttcatcag cgcgtcgaaa
    17581 ccctgctggg cgacctgcgc ggggtcgtcc ttgtcgcccg tggcgacctt ggtgtcctgc
    17641 atgccggcgc ggtcgaagaa ctccgtgtcg gtcgggccgg gcatcagcgt ggtcacgctg
    17701 accccggtgt cgcgcagctc ttcccgcagg ccctgcgcga acgacgcgag gaacgccttg
    17761 gaggccgcgt agaccgcgtg gaacgggccc ggcgcggtgg cggcgacgga cgacgtgaag
    17821 agcaccttgc cctccttgcg gtccaccatg tcgccgatca ggcggtgcga gaggtgcacg
    17881 gccgagcgga cgttcaggtc cacgatctcc aggttgtcgt cgaccgacgt gtcgcgcacg
    17941 aagtcgccgc cgacccccac gcccgcgttc accgcgagca cgtcgaccgg gcgccccatc
    18001 gcacggacgc gcgccacgac ggactccacg ccctcgtagc cgcgcaggtc cgcccgcacg
    18061 ggttccacgt gcaccccgcc gctgcgcaac cgcagttgcg cggccgcgtc gtcgatccgt
    18121 tcgtcctccg cgacgaccac gacgtcgaag gcgttgtccg cgaggacttt cgcgagttcg
    18181 taccctattc cactggacgc accggtcacc acggcaagcg cattcacagg tgttctccct
    18241 ccgggtcgac gccccggata cccgtggcca ccaggtcgat gcgcatcggc cgaaagaccg
    18301 atgcaacctc ggcgacccat caggtgtcct tatcggtagg ttggtcgaaa cgacatgggg
    18361 gacattcgtg cgcaaaattc ttctcgcgcc gctgtgcgcg ctggtcacgg tgggcgtggc
    18421 tgcgtgcagt ccgtcaggtc cggatcaggc caacccggag ctggcgccac gcggcacgac
    18481 gatgaccaag gtcaagccga ccaggcagga cctgaccacc aagctcagca tcgcgggcaa
    18541 ggtcgagatg aacccgacgt tcgggctcgt cgcgccggtc gcgggccagg tgcggtactt
    18601 cgacgtgccc gcgccgaacg gcacgccgac caagcccatc cgggtcgcga ccgtgtggaa
    18661 ggaccagacg ccgaactacg tcgaggcgcc cgcggggtcc acgttcagcg gcaggctcgt
    18721 cgacgacaag gcgacggtga cggcgggcat gccgatcgcg tcggccaagc acgtcggcta
    18781 cgcgctcgtc ggcgacatcg acgggcagca ggcgtacaag atcagcggcg cgctgaccga
    18841 cgtgacggcg cagatcaaga acggtcccgg tccgttcccg tgcacggtgc tcggcacgat
    18901 cgccgcgctg ccgcagggca cgatcccgga gaagccgccg gtcacgcagg acaacaagga
    18961 cggcgagaag aaggaccagc cgcagcagca accccagcag caacaacagc agcagccgag
    19021 ctcctcgacg ggcctgcgca tcgtgtgcag cgcgcccccg gacgtgcaga tgatcaacgg
    19081 cgccaccgcg tcgatcgagg tcaccaccgg caaggcggcg caggcgctgg tcgtcccggt
    19141 cgaggcggtc gcgggccagc agggcaaggg caaggtcgac gtcatccagc ccgacggttc
    19201 gcgccgcacc accgacgtgg tgctgggcct gaccgacggc aaggtcgtcg aggtcaagtc
    19261 gggcctcacc ggcgacgagg agctcgcggt gcccggcccc aacctgccgg aggggcagca
    19321 gcagggcggc ggccagcagc agaagccgac gggtccgtga tgacccagac cttcgaccag
    19381 ccgacggtgc aggtgcaggc gccgctgctg cagctcaacg gcatcacgaa agtcctgaag
    19441 gggcaagggg aaccgcgcac gatcctgtcc ggtgtggact tcaccgtcca cgcgggacag
    19501 agcgtggcga tcctcggccg ctccggctcc ggcaagtcga cgctgctgtc gctgatcggg
    19561 ctcttcgacc gcgccgacga gggccagtac ctcctgcacg gcgacgacat cacgaagctc
    19621 cccgagcgca gggcggcggc gttgcgcagc gcggagttcg ggttcgtgtt ccagcgcttc
    19681 ttcctgctca agcacctcac cgcggcgcag aacgtcgcga tggcgctcgt caacggccag
    19741 ggctggtcgg cgcggcgcaa gcgcaggcaa caggtgatgg acgcgctgga gcaggtcggc
    19801 atcgcgcacc tcgcgaagtc caagcccacc aggctttccg gcggtgagca gcaacgcgtc
    19861 gccatcgccc gcgccctcgt gcggcagccg cggatcatcc tcgcggacga gcccacgggc
    19921 gcgctagaca cggagaccgg caacctcgtc gtcgaggtgc tgctcaacac gaccaggcag
    19981 ggctgcggcc tcgtgctggt cacgcacgac cacgaccacg cgcgcaagat gggccgcgtg
    20041 ctggagctgc gcgacgggcg gttcaactga tgctttccgg caagttccgg tccgccctcg
    20101 tcatcggcgg acagggcatc cgcgcccgaa aactgcgcac gttcctctcg atggtgtcgc
    20161 tgttcctcgg cgtcctcgcc gtcgtcgccg tgcaggcggg cgccgagatc gccgaacgcg
    20221 cgatgctcac cgacgtcgag ctccagtcgg gcaaggacgg cacggtcacg ggctacgtcc
    20281 ccggtgagaa gggcgcgccg ggcatcgtcg aggccatgat gaagggccgc acggacgcgg
    20341 tcgcgatgat cggctcgaag gcgatcatcg gtgagcccgg cgtgcgcccg atcaacgagg
    20401 gcggcatgcc gttcgagtac gcgggccgcg gcggcgacta ctccggcccg caggtctact
    20461 gcgacgcgaa cggcacctgc accgagcaga aggcgcagga gaagaagccg gacggccagg
    20521 cgatcgaggt cagcatggtc gcgctgaccg gcgacatccg cccgttcaag ccgttccgcc
    20581 cggtctccgg cagctggctc gagttcgaca ccgcgccctc gctcgcgccg aggatcgtgc
    20641 tgaacgagga ggccgccaag ggcctgcggc agtaccgcgt ccccggcgag atgatgatcg
    20701 acggcgccac ccaccacgtg tcgccgcaga tcacgggcgt cgtgcaggac ggctacctcc
    20761 agcctcgcat ctacatgcgc ctcgacgagc tgcgcacgtg gatgcccgcg gccgccgaga
    20821 cctccgagat cgaccggatg cgcggcggcg gcacgaacct cgagctctac ctgcagccgg
    20881 gctccgacga gctccagcag ctgctgaagg cgaagctcgc gggcgtcggc atcccgcagg
    20941 accagatgca cttccaggtc gtgaagtcca aggagcgcat ggagtccgag ctgcgcatca
    21001 tgcggctgat cttcctcggc atggcgttcc tggtgctgct gatcggcgtc gcgggaatcc
    21061 tgaacgtcgg cctcgcgacg gtcggcgaac gggtcgagga gttcgccctg cgccgtgcgg
    21121 tcggcatgtc ccgcatgctg ctcgccggca tcgtgctcgc cgagaccctg ctcacgggcc
    21181 tgctgacggc ggcgctggcg atcggcgcgg gcgcggccgg gctgcaggtg gcgctgatga
    21241 tgttcggcag ccgcttcccg tcgttgcagg gcaccgcctt cccgtgggag gcgggggtcg
    21301 cgggcgtgat cgccgggttg atcgcgggtg tgctgggtgg tctcatcccg gccatccggg
    21361 cggcgcggat cccgatcgcc acagtcatgc gagcctgagt gccgtggccg ccgaaccggg
    21421 ggttcggcgg ccacagcgct gtcggctcgt cgccggcgaa gccccggacc gctgtgctgc
    21481 gggccggggt ttcgcgttct ccgagggact agttgagctc gtccgggttc ggcccgatgc
    21541 gcccgccacg gtccagagtg gacagagcct ccacctcggc gtccggcagc tcgaagtcga
    21601 acacgtcgat gttctcccgg atccgcgacg gcgtcacgga cttcgggatc acgacgttgc
    21661 cgagctgcag gtgccagcgc agcacgacct gggccgcgga cttgccgtgc gcgagcgcga
    21721 tcttctgcac caccgggtcg gtgagcagct cgccgccctg gccgagcggc gaccacgcct
    21781 cggtgacgat gccgtgctcg gcgtggaacg cgcgcaggtc ggcctgctgg aagtacgggt
    21841 gcagctcgat ctggttgacc gcgggcgtca cgccggtctc gtcgatcagc cgctggaggt
    21901 gcgcgggctg gaagttggag acgccgatcg cacggacgcg gccctccttc tgcagctcca
    21961 cgaacgcctt ccacgtgtcg acgtagttgt cgcgcgccgg ggtcggccag tggatcaggt
    22021 acaggtcgag cacgtcgagg cccagcttgg acatcgacgc gtcgaacgcg cgcagcgtgt
    22081 tgtcgtggcc gtggtcgtcg ttccacagct tggtggtgac gaagacctcg tcacgggcca
    22141 cgccggactg cgcgatcgcc gcgccggtgc ccgcctcgtt gccgtaggcg gcggcggtgt
    22201 cgatgctgcg gtagccggcc ttcagcgcct ccgcgacggc cggggtggcc tccgcgtcgg
    22261 gcacctgcca gacgccgaaa ccgagctggg gcatgacaac gccgttgttg agcttcacgg
    22321 tgttcaagag aaatccttac ggtcgttacg ggatcagcgt cggtgcggtg ccgccgtcga
    22381 cgcgcaacgc ggctccggtc gtcgcggacg acaggtccga cgcgacgtag gtgatgaggt
    22441 tcgcgacctc gtggggacgg atcaggcggc ccagcagcag cgtggggcgt tcggtgcgga
    22501 cgaactcggc ctcgccgccc tcaccgacgc ggtcgcggat gaactcctcg acgccgggcg
    22561 tcagggtcgg gccgggcagc accgagttca cggtcacgcc ggtgcccttg
//
