LOCUS       NZ_CP099738            24537 bp    DNA     circular CON 27-AUG-2024
DEFINITION  Lentzea sp. HUAS12 chromosome.
ACCESSION   NZ_CP099738
VERSION     NZ_CP099738.1
KEYWORDS    RefSeq.
SOURCE      Lentzea sp. HUAS12
  ORGANISM  Lentzea sp. HUAS12
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Lentzea.
REFERENCE   1  (bases 1 to 9676923)
  AUTHORS   Ping,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-JUN-2022) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024125735.1-RS_2024_08_27
            Annotation Date                   :: 08/27/2024 06:34:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,161
            CDSs (total)                      :: 9,080
            Genes (coding)                    :: 8,988
            CDSs (with protein)               :: 8,988
            Genes (RNA)                       :: 81
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 92
            CDSs (without protein)            :: 92
            Pseudo Genes (ambiguous residues) :: 0 of 92
            Pseudo Genes (frameshifted)       :: 21 of 92
            Pseudo Genes (incomplete)         :: 77 of 92
            Pseudo Genes (internal stop)      :: 3 of 92
            Pseudo Genes (multiple problems)  :: 8 of 92
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:47:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 159354
            Orig. end                         :: 183891
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP099738.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Ping Mo.
FEATURES             Location/Qualifiers
     region          1..24537
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..24537
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24537
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:14537](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14537)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(107..664)
                     /locus_tag="ND450_RS00775"
                     /old_locus_tag="ND450_00775"
     CDS             complement(107..664)
                     /GO_component="GO:0042597 - periplasmic space [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020647331.1"
                     /locus_tag="ND450_RS00775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00775"
                     /product="YceI family protein"
                     /protein_id="WP_089916505.1"
                     /transl_table=11
                     /translation="MTTATNLTELTGDYVIDGSHSRIGFVARHAMVTKVRGAFNEFDGK
                     IKIDGDKPENTTAEVTIKAASIDTRNAQRDGHLTTNEFLDVETFPEIKFVSTAAKQIDD
                     DNFEISGDLTIKDVTKNITIPFAFEGVAVDPFGNTRVGFEGSHTINRKDYGVSWNAALE
                     AGGVLVSEKVVLEFEISAIKQA"
     gene            759..1292
                     /locus_tag="ND450_RS00780"
                     /old_locus_tag="ND450_00780"
     CDS             759..1292
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017987699.1"
                     /locus_tag="ND450_RS00780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00780"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_253324231.1"
                     /transl_table=11
                     /translation="MTRWLEPEQQQAWRAYVRMQGELNAHLSRQMSVDSDISMADFAVL
                     VQLTDTREERVRVLELARSLHWEKSRISHHVARMEKRGLVRRESCGSDGRGSFVVLTDQ
                     GRSAIEAAAPAHAEMVHKLVFDQLTASEVTALQAISEKIFTRLTTGECAAVVARCDADD
                     AMEVVPQESGCSEA"
     misc_feature    1197..1199
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(1197..2141)
                     /locus_tag="ND450_RS00785"
                     /old_locus_tag="ND450_00785"
     CDS             complement(1197..2141)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015104348.1"
                     /locus_tag="ND450_RS00785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00785"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_253324232.1"
                     /transl_table=11
                     /translation="MLRSVAVPLIDGVAPFEFGLLCEVFGIDRTEEGVPLIDFRVCGEI
                     PNEPVPMGVRGVSITPEHGFDALQSVDLVALPAARVRDEYPEKLVKALRETDATLLSVC
                     SGAFILGAAGLLDDRHCTTHWREARTFQERFPKARLDADVLFVDDGNIITSAGTAAGID
                     ACLHLVRRELGTKVANTIARRMVVAPQRDGGQRQFVELPIPECSSDSLEPVLERVLDTI
                     ADNHTVATMAKLAVMSERTFARKFAAETGTTPNKWLSLQRVLHARRLLEETDLDVDAVA
                     TRSGFGTAALLRHHFHRVVGVAPSDYRRTFSCR"
     gene            2213..2362
                     /locus_tag="ND450_RS00790"
                     /old_locus_tag="ND450_00790"
     CDS             2213..2362
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS00790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_00790"
                     /product="hypothetical protein"
                     /protein_id="WP_253324233.1"
                     /transl_table=11
                     /translation="MTLAAIVLAVAALSAWLDRHRDRNAGLAGSSDVNDRDRVRVRDDL
                     RYLT"
     gene            complement(2355..3464)
                     /locus_tag="ND450_RS00795"
                     /old_locus_tag="ND450_00795"
     CDS             complement(2355..3464)
                     /GO_function="GO:0046912 - acyltransferase activity, acyl
                     groups converted into alkyl on transfer [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020495299.1"
                     /locus_tag="ND450_RS00795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00795"
                     /product="citrate/2-methylcitrate synthase"
                     /protein_id="WP_253324234.1"
                     /transl_table=11
                     /translation="MLIDAPKGLKDVVVTTTSIGDVNGAAGYFHYRGHDAIELAATRSF
                     EDVWFLFVEGRLPDGGEAAEFARRTAGLRELPESIREVLPAIARSGCTALAGLRTALSM
                     VPSRPMWDAPMSDRKADALEVSAMTPTILAALHRIKHGLDPVNPRVDLSTSANWLYMLT
                     GLEPSPWTSRAVEQYLIATIDHGFNASTFTARVVASAGADVVSAVTAAIGTFSGPLHGG
                     APDRALEALDLIGSPDNIDAWVRERIEQGDRIMGFGHAVYKTEDPRARLLKAIAMERPT
                     GLTDFAVTVERRVTELLAELKPGRQLYANVEFYAGVLMEQCGVPREMFTPTFACSRVIG
                     WCANALEQSEDTKIIRPVARYTGPEPVIR"
     gene            3507..4628
                     /locus_tag="ND450_RS00800"
                     /old_locus_tag="ND450_00800"
     CDS             3507..4628
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020495298.1"
                     /locus_tag="ND450_RS00800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00800"
                     /product="citrate synthase"
                     /protein_id="WP_253324235.1"
                     /transl_table=11
                     /translation="MESMLTTNQAARRLGVKPATVYAYVSRGLLTSTKVNRSSMFGVAE
                     VEALAQRTGARGAVAAVTDRIRTRISLLENDQLHYRGRSVPALAGTKRFEDVAHWLWTG
                     IDSEGMQFPEGQEIWMALPESATLTDRVRVAIALASVGDPLRYDLDRAVTTAKSLIADV
                     VESLPMVGRPQGTDIAERLWARLSPEPPQPDLLNAALILLADHDLAISTMAARVAASAH
                     ANPYAVVSAGMGAMEGQKHGAATTIAYRFLLQAQSDPMGTLAEHLRSGQPIPGFGHRVY
                     QSRDPRADHLLALLRSHGELVADKMMGTQPQSFPNVDLALAQFALMFKMPADAGEAIFA
                     IARIVGWIAHAMEEYREPGMRFRAMGVYTGDRP"
     gene            complement(4678..5538)
                     /locus_tag="ND450_RS00805"
                     /old_locus_tag="ND450_00805"
     CDS             complement(4678..5538)
                     /NRPS_PKS="Domain: Abhydrolase_1 (50-146). E-value:
                     2.1e-16. Score: 52.2. Matches aSDomain:
                     nrpspksdomains_ND450_RS00805_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029226.1"
                     /locus_tag="ND450_RS00805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00805"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_253324236.1"
                     /sec_met_domain="PF00561 (E-value: 1.2e-11, bitscore: 43.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4e-14, bitscore:
                     52.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVGKFVDQKAADRYFATYEAIRRKWPVPSEELDVETRFGATRVRR
                     SGTGTPIVLLPGAMGTSLSWYPFVADLAARHTVYAVDVIGEPGRSVQTRPMESTDDEAD
                     WLADVLAGLGHEKVHLVGISRGAGLALNLATRRPAGVAGVLAFEPGGFGINFRKFVLWS
                     IGELSRWWLPAAILRRVSGGDPAVRHTMRPLVFRGMKYKVQMAPLHVFTDDELRSIDVP
                     TYFILGERSLIKAPELAARVESLVPNVRTEIVPGATHALNLEELELTNARILAFAGEDH
                     AGLPD"
     aSDomain        complement(5101..5388)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ND450_RS00805_Abhydrolase_1.1"
                     /evalue="2.10E-16"
                     /label="ND450_RS00805_Abhydrolase_1.1"
                     /locus_tag="ND450_RS00805"
                     /protein_end="146"
                     /protein_start="50"
                     /score="52.2"
                     /tool="antismash"
                     /translation="PIVLLPGAMGTSLSWYPFVADLAARHTVYAVDVIGEPGRSVQTRP
                     MESTDDEADWLADVLAGLGHEKVHLVGISRGAGLALNLATRRPAGVAGVLA"
     misc_feature    complement(5557..5573)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.6"
                     /tool="antismash"
     misc_feature    5569..5579
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 19.14"
                     /tool="antismash"
     gene            5629..6228
                     /locus_tag="ND450_RS00810"
                     /old_locus_tag="ND450_00810"
     CDS             5629..6228
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005162990.1"
                     /locus_tag="ND450_RS00810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00810"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_253324237.1"
                     /transl_table=11
                     /translation="MPKRVDHDEKRRDLAEALFRIASARGLQAVTLRAVAAEAGVSMFQ
                     IQYYFPTKEDMLRHAWQRITELGAERAGRGIAEAARTGDERAVIRACVLGVLPTDERSR
                     MLCAVQIAYFAVDVARGSQAPDQQAMLPHLVRLIADQLGHARERGRIAPGLDLHLEADA
                     LAIMTGGLLSGMLVDAYDATRAAEIVDYRLDQLFTG"
     gene            6288..7385
                     /locus_tag="ND450_RS00815"
                     /old_locus_tag="ND450_00815"
     CDS             6288..7385
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013884.5"
                     /locus_tag="ND450_RS00815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00815"
                     /product="acyltransferase"
                     /protein_id="WP_253324238.1"
                     /transl_table=11
                     /translation="MRLSAVDNLKVILVAWVIGGHALLGYAAIGGWPYDEVNEVTFHPG
                     AETVLAALIGPSGLFFMGTFYFMAGIFTPGSIERKGRRRFIAERLVRLGTPWVVSALVV
                     WPTFVWIAYNGAGRDVSWWQAFTDRDPFLDSGSLWFVGVLLIFSVGVALAPPIKERAIT
                     GGTVVGMTVAVAGTTFLTRLVFPARSGQVGDLHLWWWPQCLGMVLLGAIGGRKLAERVP
                     DEIYRMTRNVVIGTIALLPVAAAMMGVLDLAKSAEPFLGGFRWQAAVLALVEGILVVAG
                     SLWLIGLAQRRLTRQGPFVDGLARSAYVAFVVQGPILLALATGLRPLDLPAEVKAPLVG
                     MAAIVLSFGIGWVVTSRRGASARSS"
     misc_feature    6291..6309
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.94"
                     /tool="antismash"
     gene            complement(7348..9054)
                     /locus_tag="ND450_RS00820"
                     /old_locus_tag="ND450_00820"
     CDS             complement(7348..9054)
                     /EC_number="2.2.1.7"
                     /GO_function="GO:0008661 - 1-deoxy-D-xylulose-5-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015103446.1"
                     /locus_tag="ND450_RS00820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00820"
                     /product="1-deoxy-D-xylulose-5-phosphate synthase"
                     /protein_id="WP_253324239.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 8.1e-79,
                     bitscore: 263.7, seeds: 174, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLADITSPADVRALSSSELGALASEVRSFLISKVHRTGGHLGPNL
                     GAVELTIAVHRVFTSPVDVVLFDTGHQSYVHKMLTGRCSDFDSLRQAGGMSGYPSAAES
                     AHDVVENSHASTALSYADGLAKAFELGGTERRVVAIVGDGALTGGMCWEALNNIGGSSR
                     PVVVLLNDNGRSYDPTAGGFAASLLDGTARGLFEALGLAYIGEVDGHDVHAVENALWEA
                     KSLGRPVVVHCKTVKGKGYPAAESDEADRMHAVGAAGAAGGRTWTDAFSDEIVAIGAER
                     PDVVCLTAAMLEPVGLRPFSERFPSRVFDVGIAEQHAVTSAAGMAMGGLHPVVAVYATF
                     LSRAFDQLLMDVALHRLPVTFVLDRAGVTGPDGASHHGMWDASVLPVVPGLRLAAPRDP
                     ASLAALLREAVEVADGPTVVRYPKAAVGPDVPAVRRVGHFDVLREDPDAEVLLVAVGPL
                     AGACLAAADELASHDVRVTVVDPRWTAPLDPHLVKYSGRHRLVLAVEDTTSTGALGARL
                     GQALTGTSVCVATFALPPRFLPHDSRARILRAHGLDAAGITTSVLKRLGVR"
     gene            complement(9044..9985)
                     /gene="ispH"
                     /gene_synonym="lytB"
                     /locus_tag="ND450_RS00825"
                     /old_locus_tag="ND450_00825"
     CDS             complement(9044..9985)
                     /EC_number="1.17.7.4"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051745 - 4-hydroxy-3-methylbut-2-enyl
                     diphosphate reductase activity [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /GO_process="GO:0050992 - dimethylallyl diphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="ispH"
                     /gene_synonym="lytB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013673157.1"
                     /locus_tag="ND450_RS00825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00825"
                     /product="4-hydroxy-3-methylbut-2-enyl diphosphate
                     reductase"
                     /protein_id="WP_089916483.1"
                     /transl_table=11
                     /translation="MTEHPPRSVLLASPRSFCAGVERAIEIVERLLDQRGGPVYVRKQI
                     VHNVHVVRSLEARGAVFVEELSEVPFGATAVFSAHGVSPAVRAEARLRDLDVLDATCPL
                     VTKVHSEARRFAERGDTIVLIGHAGHEEVEGTLGEAPDQMVLVETVEDVLALEITGPVS
                     YLTQTTLAVDETAEVIEALERKFPHVRGPGSDDICYATTNRQIAIREVAEQSDLVLVVG
                     SKNSSNSVRMVELAARGGTPAHLIDDASEIDPAWLAGVTSVGLSAGASAPPELVDEVVE
                     ALKAMGSVSVSTHTTATETISFTLPLAVRRAG"
     misc_feature    10000..10014
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     gene            complement(10001..11035)
                     /locus_tag="ND450_RS00830"
                     /old_locus_tag="ND450_00830"
     CDS             complement(10001..11035)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020666922.1"
                     /locus_tag="ND450_RS00830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00830"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     polyprenyl transferase"
                     /protein_id="WP_253324240.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.4e-60, bitscore:
                     203.9, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEPLAAGRPSGELLAWSRSLVLPALRKAVDQLPPAMRTIAEYHH
                     GWRDEYGNPVLENGGKAIRPALVLLAAEAVGGTAGSAVPAAVAVELIHNFSLLHDDVMD
                     RDTTRRHRATAWTVFGVNAAILAGDALQALALDVLAASGHPRTLEAIRTLNDATVALLE
                     GQAYDLDFETRDDVRVSEVERMSRGKTGALLGASTSLGALYGGGSDEQVEAMRGYGTEL
                     GLAFQHVDDLLGIWGDPAVTGKVAQMDLVNRKKSLPVVRALNAGVPASAELASLYFGEH
                     EMNAETLARAADLVDQAGGRAWSQTQADELHTQALVHLGEASPTARAAVELGTLAQLVT
                     HRDH"
     gene            complement(11051..12451)
                     /locus_tag="ND450_RS00835"
                     /old_locus_tag="ND450_00835"
     CDS             complement(11051..12451)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020666923.1"
                     /locus_tag="ND450_RS00835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00835"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_253324241.1"
                     /transl_table=11
                     /translation="MTVTDPGLGIEDKQLSLSRAAARNLATTTKSAPQMQGISPRWLLR
                     MLPWVEAKGGAYRVNRRLSYAIGDGRVTFTAVGSEVRIVPQELAEFKLLRGFEDEAALT
                     AVANRFEQREYEPGEVIAHRGQSVDEIIVIAHGKVTKTGRGEYGDDVALGTIADGEYLG
                     DEPVLSGADKNWSFTARALTPTTAVVLSRAAFAQLNGQIEPMREHIEQQLANPSKTSNK
                     HGEAEIDISSGHDGEPTLPGTFVDYELRPREYELSVAQTIVRVHTRVADLYSQPMDQVE
                     HQLRLTIEALRERQEHELVNNKEFGLLANADLKQRVSTHSGPVTPDDMDELISRRRNTR
                     LILAHPRAIAAFGRQLNKRGLYVPTVDVEGQQLQSWRGVPIAPCDKIPVNKNGTTSIIA
                     MRLGEEKQGVIGLRQTGIPDEYEPGLNVRFMGIDEHAMLKYLVSTYYSAAVLVPDALGV
                     LENVEIGL"
     gene            complement(12473..13480)
                     /locus_tag="ND450_RS00840"
                     /old_locus_tag="ND450_00840"
     CDS             complement(12473..13480)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.4"
                     /locus_tag="ND450_RS00840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00840"
                     /product="hypothetical protein"
                     /protein_id="WP_253324242.1"
                     /sec_met_domain="T1TS (E-value: 1.8e-47, bitscore: 161.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVEVPSFDMPFAARLSPHVDRVRRHTKKWVRDMGMLGGVPWTEAF
                     YDAADYGGFGPLTHPTASLEDLKHINDWHTWGFYVTDAFQAFLRSRDVAGGKAFVAGLK
                     SVLSGSAPMNPAEKGLADLVSRSTLDSFDSEHLAEFLDALLWELHNTAQGRVPDPIDLV
                     EMRRRSIATELSAKLARGSVGAELPEELLRNSTMRALVDSFGDVPALRQEIVGFDRTYA
                     TGGSTTSAVLAVQQFFGCETQQAVSVVADLIAARLRQIGAIIGELPSLATEYGLDAEAK
                     AGLHRYAEALKSWLAGELLWTRRSGRFTHSPAPTRTSFHRPTGLGTAALSVSSR"
     gene            complement(13473..14537)
                     /locus_tag="ND450_RS00845"
                     /old_locus_tag="ND450_00845"
     CDS             complement(13473..14537)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.4"
                     /locus_tag="ND450_RS00845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00845"
                     /product="hypothetical protein"
                     /protein_id="WP_253324243.1"
                     /sec_met_domain="T1TS (E-value: 4.2e-79, bitscore: 266.0,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEFYVPHPARMNPHLERARAHSTQWARDMGMLDTGVWTDEVLAG
                     DDYGFMCAWTHPDAPAEVLDLITDWYVWVFYFDDEFFAEFKQGKDVAGARAYLDRLPAF
                     MPLNGTDPWPEPRNPTERGLVDLWQRTIPLMSQDWRRRFTTSTHNLLLECMWEIKNIES
                     GTVANPIEYIEMRRKVGGAPWSANLVEVSEAAEVPASVAGTRPLRVLSDTFSDAIHLRN
                     DIFSYEREVLREGENSNGVLVFEKFFGHDTQTAVEAVNTLLTSRLHQFENTVFTELPQL
                     FAENSLGPEDQARVLKYVKGLQDWQSGGHEWHLHAGRYTKVEGGAGNSAFFRTILRGPT
                     GLGTSAAWPGVSRG"
     gene            complement(14558..15964)
                     /locus_tag="ND450_RS00850"
                     /old_locus_tag="ND450_00850"
     CDS             complement(14558..15964)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159827.1"
                     /locus_tag="ND450_RS00850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00850"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_253324244.1"
                     /transl_table=11
                     /translation="MTVTDSDLNEGRQQLSLGTAAARNLATTTKSVPQMQGISSRWLLK
                     VLPWVQAAGGAYRVNRRLTYTLGDGRVSFTNIGAEIRVVPQELTELALLKGFDDEEVLA
                     ALAGRFRQQEFGIGDVIVEKGRPKDTVVLIAHGKVDKVGTGEYGGETVLGNLADGQYFG
                     ETVLAGPQGEWEFTAKAVTPVTVLSLSWEDFQALNGEAGGLRAHIQHTFNSRNKPQDEH
                     GEAEIDLSSGHDGEPVLPGTFVDYELSPREYELSVAQTVLQVHTRVADLYNNPMDQVEQ
                     QLRLTIEALRERQEHEIVNNRSFGLLHNADLKQRIHTRSGPPSPDDFDELLSIVWKDPG
                     YFVAHPRTIAAFGRELNKRGLYPQHIDFNGQQVPAWRGIPILPCNKIPVSDTRTSSVML
                     IRTGEQNQGVIGLHQTGIPDEYQPGLSVRFMGINDQAIINYLVSAYYSAAIMVPDAIGV
                     LEHVELGREG"
     misc_feature    complement(16018..16031)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.14"
                     /tool="antismash"
     misc_feature    complement(16054..16069)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.12"
                     /tool="antismash"
     misc_feature    complement(16243..16259)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.43"
                     /tool="antismash"
     misc_feature    16298..16318
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.22"
                     /tool="antismash"
     gene            complement(16322..16789)
                     /locus_tag="ND450_RS00855"
                     /old_locus_tag="ND450_00855"
     CDS             complement(16322..16789)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013230675.1"
                     /locus_tag="ND450_RS00855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00855"
                     /product="heme-degrading domain-containing protein"
                     /protein_id="WP_253324245.1"
                     /transl_table=11
                     /translation="MNSEELLAQERRLQFSRFGNDVAIELGLHLLDAAREQGLPIAISV
                     RRGGHRLFHAALPGTSPNNDRWLERKARVVELFGHSSFYVGTEFREKGTTFEAESRLDP
                     DLYAAHGGVFPVVVRGTGPVGTVGVSGLPQAEDHAFVVDQLESFLNSRDAQ"
     gene            complement(16786..17793)
                     /locus_tag="ND450_RS00860"
                     /old_locus_tag="ND450_00860"
     CDS             complement(16786..17793)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009942595.1"
                     /locus_tag="ND450_RS00860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00860"
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_253324246.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 1.3e-21, bitscore:
                     76.5, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 5.3e-28,
                     bitscore: 96.5, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRVGLLGYGIAGRVFHGPLISSTEGMDLVAIVTSDPRRQAQARA
                     AHPDAKIVTADELFELDLDLVVVATPNRTHVEYAKRAIAQGVAVVVDKPFAPTSAEAAE
                     LLAAARAAGVPLTVFQNRRWDSDFLTVRKVLGELGEVRRFESRFERWIPEVWDNWREFG
                     APEEAGGLLYDLGAHLVDQALQLFGPVRSVYTELDLRRPGVQVDDDVFVALTHENGVRS
                     HLWANAHAAHHGPRFRLLGSEGAFEISGLDEQEDALAAGRRPTDSGWGHEDRTGTLGVL
                     DRATEVAVEPGAYQHFYSELQAGRIPVDPAGAVAALRVIEAAFMSARENRVVQL"
     misc_feature    17784..17804
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.97"
                     /tool="antismash"
     misc_feature    complement(17813..17829)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.11"
                     /tool="antismash"
     gene            17832..18806
                     /locus_tag="ND450_RS00865"
                     /old_locus_tag="ND450_00865"
     CDS             17832..18806
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032326.1"
                     /locus_tag="ND450_RS00865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00865"
                     /product="ROK family transcriptional regulator"
                     /protein_id="WP_253324247.1"
                     /transl_table=11
                     /translation="MDLTSLRSHNDRTVLRLVRSGAVSRASIAAEAGLTPQAVSKIVAR
                     LISAGLLEETGAVRDGGRGKPRMSLRLAADGAHAYGAYVDRDELRVVKLDLTGEVVSSA
                     VAPLAPMFTPADVLDALEPLISVDEKVLGLGIGIAGPLEHGEGVVSPNGLPGWSSIPLK
                     ALAQERLGLPVVVDKDTNAAVLAEAWRRPMRDAALVFVGTGLGVGLLLGGEVHRGARSG
                     AGEFGHTTIQLDGPLCVCGRRGCVEAVHAAAKDDEAARVLAAAVTNLVQLLDLDQIVLS
                     GRKVLRSPELYLRAMPDVDVSVTSYGPDLVPVGAGLLVLGELF"
     gene            18817..19617
                     /locus_tag="ND450_RS00870"
                     /old_locus_tag="ND450_00870"
     CDS             18817..19617
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020644536.1"
                     /locus_tag="ND450_RS00870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00870"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_253324248.1"
                     /transl_table=11
                     /translation="MDVEHVVGSPHPRLRPFVTRYSGYRMRTEPGIHRGLPSRSLTLVV
                     TLDGTVDLADGRFATLCGGLHDEAVIITHDGFQHGVQCDLTPLGMRAFFGLPAGELSGV
                     TVGLDSLDAPAAELRERLRHAATWTDRFALLDLVLGRLVRPVRQQVEVAWAWQRLAAGV
                     AVADIAAEVGWSRQHLSARFAAEYGLTPKVVARVMRFERANRMLRGERRPTFTEVAAAC
                     GYTDQAHFNRDWRALVGATPSEWIAAELPFVQGGEGGAGAELAP"
     gene            19614..20012
                     /locus_tag="ND450_RS00875"
                     /old_locus_tag="ND450_00875"
     CDS             19614..20012
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020418180.1"
                     /locus_tag="ND450_RS00875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00875"
                     /product="VOC family protein"
                     /protein_id="WP_253324249.1"
                     /transl_table=11
                     /translation="MSTPAPTCWPCLSYRDAPAAIRFLVEAFGFSEHLVVPGEADGEVV
                     HCEMVWPEGGGVMLGSAVRSVGEVEATKAGAGSVYVVTDRPDELHAQALARGATEVRGL
                     RDEDYGSRGFTMADPEGNRWSFGTYRGA"
     gene            20098..23463
                     /locus_tag="ND450_RS00880"
                     /old_locus_tag="ND450_00880"
     CDS             20098..23463
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.5"
                     /locus_tag="ND450_RS00880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00880"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_253324250.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 2.2e-47, bitscore:
                     160.8, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITALAAGLLSPAATAQAEPVRTQKTSTITLISGDKVVVDERGGL
                     VRVEGRPGMSFAQYVRDDHQYVVPADAVDAVAQNSVDQRFFDVTSLHSYGYTDERTDRI
                     PLLTNGFRAAAAVEKKDAAQQWTARRTSASRAGKLWLDGKSKISLTESVPMVGAPGAWQ
                     AGFDGTGVTVAVLDTGYDRNHPELAGVVSVAKDFTPSGIQDDIGHGTHVAATVAGRGSR
                     HVGVAKGASLAVGRVCEAEWCLDSAVIAGMEWAAREVKAKVVNLSLGGDQSDGTDPLSL
                     KVNELTAETGALFVVAAGNAGTRRQVSGPASADAALAVANLTKQGVLEEWSSRGPRVGD
                     HAVKPDIAAPGTDIVAARAENTLWDFAVDDLHARLTGTSMAAPHVAGAAAVLAQRNPSW
                     KAAELKAHLMATVKPVADKPSNVGTGLLDVERAVTQQVRASVGSLSFGLLEWPHTRTFT
                     KTITYTNAGAEPVSLTLRHDLGADFAVPSSVTVPAGGSASVDVVLDPAKGLGKFFGHLK
                     ASAPGVSVVTAVGAYVEEEHHTLNLSMIGRDGKPVASEFVVVVDLSTREASVVTIENGT
                     GAARLPVADYAVIGRIDELTPNYAWFTPVSATEVAGRVSVRADVSLTLDARQGKEIRVE
                     LPERDSQVWYRDARLSVPFESDRISSIASTIDGRVPLYGLSFGPPLPELTYDSGLKGGQ
                     PLVSVVGGFPVRYYDGSRFLPPGEHELDVAERGTDVRGKLALVRHAGENPYEVARAMQD
                     AGAVAVLWAGPVPFGSEQQTAIPVIAVAEHHVAVTPAKLTLRAVAGSPVSYTLFLRDKG
                     ALPVGVKKVRHSELAEVKARYHTSGPDGSVLQRNSPVVNGVLGRVLDERLSAPAQRTEY
                     FTPGISWYQEGFDGRSSGAGDDPSTTSWADLEPVTFQAGRKYERTHLRGITSPRLGGSS
                     VVTWADGGGVERSGDLINARISPFGGSGWVENWRQGGWGTLELRHDDATLGYSDVRRGS
                     FHAPARDGRYKLLLDASRDGLALSTSVRTTWEFSAASDGRLPLVEVDYSVPVDLRNSWK
                     AGLAMPVKFTASGGARVLEAYASFDDGANWVPVKSVVPPGGKAGGYVSLRVVARDAAGN
                     SVDQTVLRAYRLRA"
     gene            23611..24348
                     /locus_tag="ND450_RS00885"
                     /old_locus_tag="ND450_00885"
     CDS             23611..24348
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020502230.1"
                     /locus_tag="ND450_RS00885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_00885"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_253324251.1"
                     /transl_table=11
                     /translation="MGTFEELVAEGAAVPLEGWDFSWFEGRATEERPPWGYAGLIAARL
                     AVVSAALDLQTGGGEVTASAPVLPPRMAATESWPPNALVASRRLPLVVLAADAGPLPFR
                     SSSFDLVISRHPVVTPWGEIARVLRPGGTYFSQQIGAGTNRELTDFMMGPQPVSPARSV
                     EVARAEAEAAGLEVLRLEPVWLRVEFFDVGAVVHFLRKVLWTVPGFTVERYRDRLLDLH
                     AHIQEHGAFVSTSTRFLVEARKP"
     misc_feature    complement(24485..24500)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.96"
                     /tool="antismash"
ORIGIN
        1 ggactgctcg tcgtcgggtc acgggggcgt ggcggtttcg ccgggatgct gctcgggtcg
       61 acctcgcagg ccctggtcta ccacgccccg tgcccggtgg ccgtggtcag gcctgcttga
      121 tcgccgagat ctcgaactcg aggacgacct tctcgctcac cagcacgccg ccggcctcga
      181 gcgccgcgtt ccagctgacg ccgtagtcct tgcggttgat ggtgtgcgag ccctcgaagc
      241 ccacgcgggt gttgccgaac gggtcgacgg ccacgccctc gaaggcgaac gggatggtga
      301 tgttcttggt gacgtctttg atggtgaggt caccggagat ctcgaagttg tcgtcgtcga
      361 tctgcttggc ggcggtcgag acgaacttga tctccgggaa ggtctcgacg tcgaggaact
      421 cgttcgtcgt caggtgaccg tcgcgctggg cgttgcgggt gtcgatgctc gcggccttga
      481 tcgtgacctc ggcggtggtg ttctccggct tgtcaccgtc gatcttgatc ttgccgtcga
      541 actcgttgaa cgcaccacga accttggtga ccatcgcgtg gcgagcgacg aagccgatgc
      601 gggagtgcga gccgtcgatg acgtagtcgc cggtcagttc ggtgaggttg gtggcggtgg
      661 tcatggtgtc aagtccttcg gttgctcgat ttggttgaag tctcactcac cctgcccgaa
      721 cgtggatgat gtgtcaacta ttcccgtatg ctgaaccggt gacacgatgg ttggaacctg
      781 agcagcagca ggcgtggcgt gcctacgtcc gcatgcaggg ggagctcaat gcgcatctga
      841 gcaggcagat gtcggtcgac tcggacatct cgatggccga cttcgccgtg ctggtgcagc
      901 tcaccgacac gcgtgaggag cgcgtgcgcg tgttggagct tgcacggtcg ttgcactggg
      961 agaagagccg catctcacat cacgtcgcac ggatggagaa gcgcggtctg gtgcggcgag
     1021 agagttgtgg cagcgacgga cgtgggtcgt tcgtcgtgct cacggaccag ggtcgctccg
     1081 cgatcgaggc cgccgcgccg gcgcacgccg agatggtgca caagctggtg ttcgaccagc
     1141 tcacggcctc ggaggtgacg gcgttgcagg ccatctccga gaagatcttc acgcgcttaa
     1201 cgacaggaga atgtgcggcg gtagtcgctc ggtgcgacgc cgacgacgcg atggaagtgg
     1261 tgccgcagga gagcggctgt tccgaagcct gacctggtcg cgaccgcgtc gacgtccagg
     1321 tcggtctctt cgagcagcct gcgcgcgtga agcacccgtt ggagtgacag ccacttgttc
     1381 ggggtggtgc cggtctccgc ggcgaacttg cgtgcgaagg tccgttcgga catgacggcg
     1441 agcttcgcca tcgtcgccac cgtgtggttg tccgcgatcg tgtcgagcac ccgttccagc
     1501 accggctcca ggctgtcgga gctgcactcc gggatgggga gctccacgaa ctgccgctgg
     1561 ccgccgtcgc gctgcggcgc cacgaccatc cggcgcgcga tggtgttggc gaccttggtg
     1621 ccgagttccc tgcgcacgag gtgcaggcag gcgtcgatgc ccgccgccgt gccggcgctg
     1681 gtgatgatgt tgccgtcgtc cacgaacagc acgtccgcgt cgagccgggc cttcgggaag
     1741 cgctcctgga acgtccgcgc ctcgcgccag tgcgtcgtgc agtgccggtc gtcgagcagt
     1801 ccggccgcgc ccaggatgaa cgccccgctg cacacgctga gcagcgtcgc gtcggtctcc
     1861 ctgagcgcct tgacgagctt ctccgggtac tcgtcgcgaa cccgcgcggc gggcagtgcg
     1921 acgaggtcga cgctctgcag cgcgtcgaac ccgtgctccg gcgtgatgct cacgccgcgg
     1981 acgcccatcg gcaccggctc gttcgggatc tccccgcaca cccggaagtc gatcagcggc
     2041 acgccctcct cggtccggtc gatgccgaac acctcgcaga gcaggccgaa ctcgaacggc
     2101 gcgacgccgt cgatgagggg aaccgccacc gatcgcagca tggcaggatt ttagcgcgca
     2161 ccgtcagatc tgccactgtt ggcgggatat tggtggccgc aaacttactg acatgactct
     2221 tgcagcgatc gtcctcgcag tggcagctct ctccgcctgg ctcgaccggc accgcgaccg
     2281 caacgccggt ttggcgggct cgtccgacgt caacgaccgc gaccgcgttc gcgtgcgcga
     2341 cgacctgcgg tacctcacct gatgaccggt tccggtcccg tgtagcgggc gaccgggcgg
     2401 atgatcttcg tgtcctcgga ctgctcgagc gcgttggcgc accacccgat cacccggctg
     2461 cacgcgaacg tcggcgtgaa catctcgcgc gggacaccgc actgctccat cagcacgccg
     2521 gcgtagaact cgacgttcgc gtagagctgc cggccgggct tcagctcggc cagcagctcg
     2581 gtgacccgcc gctcgaccgt gaccgcgaag tccgtgagcc cggtcggcct ctccatcgcg
     2641 atcgccttga gcagccgtgc ccgcggatcc tccgtcttgt agacggcgtg gccgaagccc
     2701 atgatccggt cgccctgctc gatgcgctcc cgcacccagg catcgatgtt gtccggcgac
     2761 ccgatgaggt ccagcgcctc cagcgcccgg tccggcgcgc cgccgtgcag cggcccggag
     2821 aacgtcccga tcgccgccgt caccgccgac acgacgtccg ccccggcgct cgcgaccacg
     2881 cgtgccgtga aggttgacgc gttgaagccg tggtcgatcg tcgcgatcaa gtactgctcg
     2941 actgcacggc tcgtccacgg tgacggctcc agtccagtca acatgtacaa ccagttcgcc
     3001 gacgtggaca aatcaaccct ggggttgact ggatcaagtc catgcttgat ccggtgcagt
     3061 gcggcgagga tcgtcggcgt catcgcgctg acctcgagcg cgtccgcctt gcggtcgctc
     3121 atgggcgcgt cccacatcgg ccggctcggc accatcgaca gcgcggtcct gagcccggcc
     3181 agcgccgtgc acccggaacg cgcgatggcc ggcagcacct cccggatcga ctcgggcagt
     3241 tcccgcagcc cggcggtccg ccgcgcgaac tcggcggcct cgcccccgtc cggcaaccgg
     3301 ccctcgacga agaggaacca cacgtcctcg aacgaccgcg tggcggccag ttcgatcgca
     3361 tcgtgcccgc ggtagtggaa gtagcccgcg gcaccgttca cgtccccgat cgacgtcgtg
     3421 gtgacgacaa cgtctttaag ccctttgggt gcatcaatca acatgcacaa caggctccgt
     3481 caacatgtct tgtacagtca acgttgatgg aatcaatgtt gacgacgaat caagctgccc
     3541 gtcgcctcgg cgtgaagccg gcgacggtct acgcgtacgt cagccgcggg ctcctgacca
     3601 gcacgaaggt gaaccgctcc agcatgttcg gcgtcgccga ggtggaagcc ctcgcgcagc
     3661 gcaccggcgc gcgcggagcg gtggcagctg tgacggatcg catccgcacg cgcatctccc
     3721 tgctggagaa cgaccagctc cactatcgcg gcagatcggt ccccgcgctc gccggcacca
     3781 agcgcttcga ggacgtggcg cactggctgt ggaccgggat cgactcggag ggcatgcagt
     3841 tccccgaggg ccaggagatc tggatggccc tccccgagag cgccaccctc accgaccggg
     3901 tccgcgtggc catcgccctc gccagcgtcg gcgaccccct ccgctacgac ctcgacaggg
     3961 ccgtcaccac ggccaagtcc ctcatcgcgg acgtggtcga gtccctgccc atggtcggca
     4021 ggccccaggg caccgacata gccgaacgcc tgtgggcccg cctgtccccg gagcccccgc
     4081 agccagacct gctcaacgcc gccctcatcc tgctcgcgga ccacgacctg gccatctcga
     4141 ccatggccgc gagggtcgcc gcctcggccc acgccaaccc gtacgcggtc gtgtccgcgg
     4201 gcatgggcgc catggagggc cagaagcacg gcgcggccac caccatcgcg taccgcttcc
     4261 tgctccaggc gcagtccgac ccgatgggca ccctcgccga acacctgcgc tcgggccagc
     4321 cgatcccggg cttcggccac cgcgtctacc agtcccggga cccccgcgcc gaccacctcc
     4381 tcgccctgct gcgcagccac ggcgagctgg tggcggacaa gatgatgggc acccagccgc
     4441 agtcgttccc gaacgtcgac ctggccctgg cgcagttcgc gctgatgttc aagatgccgg
     4501 cggacgcggg cgaggccatc ttcgccatcg cgcggatcgt ggggtggatc gcgcacgcga
     4561 tggaggagta ccgcgagccg gggatgcggt tccgcgcgat gggcgtgtac acgggggacc
     4621 ggccgtagcc gggtgacgac caggcgactc ccaggacgcc tggtcttcgg aacccggtca
     4681 gtccggcagg ccggcgtggt cctccccggc gaaggcgagg atccgcgcgt tggtcagctc
     4741 gagttcctcc aggttcagcg catgggtcgc cccgggcacg atctcggtgc gcacgttcgg
     4801 gacgagggac tcgacgcgcg cggcgagctc cggtgccttg atcaagctgc gctcgcccag
     4861 gatgaagtag gtgggcacgt cgatcgaccg cagctcgtcg tcggtgaaca cgtgcagcgg
     4921 agccatctgg accttgtact tcatgccgcg gaacacaagc gggcgcatcg tgtgacgcac
     4981 ggcgggatcg ccgccgctga cccggcgcag gatcgcggcg ggcagccacc agcgggacag
     5041 ctcgccgatg ctccagagga cgaacttccg gaagttgatc ccgaacccgc ccggttcgaa
     5101 ggcgaggacg ccggcgaccc ccgcaggacg ccgagtggcg aggttcagcg ccaggccggc
     5161 gccgcgcgag atcccgacca ggtggacctt ctcgtggccg agccccgcga ggacgtctgc
     5221 gagccagtcc gcctcgtcgt cggtgctctc catgggccgg gtctggaccg agcgccccgg
     5281 ttcgccgatc acgtcgacgg cgtacacggt gtgccgcgcc gccaggtcgg cgacgaaggg
     5341 gtaccaggac aacgacgtgc ccatggcgcc gggaagcagc acgatcggcg tgccggtgcc
     5401 gctgcgccgg acgcgggtcg cgccgaaccg ggtctccacg tccagctctt ccgacggcac
     5461 cggccacttc cgccggatcg cctcgtacgt ggcgaaataa cgatccgccg ccttctggtc
     5521 cacgaacttc ccgaccatca catcccccag atgtttttgc aatgcagatg caatgtaaca
     5581 gccgcgcgca gtgctcgtcg acacctgtcg ctgtgccaga gtgatcacat gcccaaacgc
     5641 gttgaccacg acgagaagcg gcgcgacctc gcggaggcgc tcttccggat cgcgtcggcg
     5701 cgaggcctgc aggcggtgac gttgcgcgcg gtcgcggcgg aggcgggcgt gtcgatgttc
     5761 cagatccagt actacttccc gaccaaggag gacatgctgc gccacgcctg gcagcggatc
     5821 accgagctgg gcgccgagcg tgccgggagg ggcatcgcgg aagcggcgcg gacgggcgac
     5881 gaacgtgccg tcatccgcgc gtgcgtgctc ggggtcctgc cgacggacga acgcagccgc
     5941 atgctgtgcg cggtgcagat cgcctacttc gccgtggacg tcgcgcgcgg cagccaggca
     6001 ccggaccagc aggccatgct gccgcacctc gtgcgcctga tcgcggacca gctcggacac
     6061 gcgcgagaac gcggccggat cgcaccgggc ctcgacctcc acctggaggc ggacgcgctg
     6121 gcgatcatga ccggcgggct gctcagcggg atgctcgtcg acgcctacga cgcgaccaga
     6181 gccgcggaga tcgtcgacta ccggctcgac cagctgttca ccggctgacg aggccggccc
     6241 cgcatggcct ctggcgtgac agccgcgaga agcggaccat gaaaagcatg agattgtccg
     6301 cagtggacaa cctgaaggtg atcctcgtcg cgtgggtcat cggcggccac gcgctgctcg
     6361 gctacgccgc gatcggtggc tggccgtacg acgaggtcaa cgaggtcacg ttccaccccg
     6421 gcgcggagac ggtgctggcg gcgttgatcg ggccgtccgg gttgttcttc atgggcacgt
     6481 tctacttcat ggccgggatc ttcacgcccg gctcgatcga gcgcaaaggg cggcggcggt
     6541 tcatcgccga gcggctcgtc cggctgggga cgccgtgggt cgtgagtgcg ctggtggtgt
     6601 ggccgacgtt cgtgtggatc gcctacaacg gggccgggcg cgatgtgtcg tggtggcagg
     6661 cgttcacgga tcgggatccg ttcctcgaca gcgggtcgtt gtggttcgtg ggggtgttgc
     6721 tcatcttcag cgtcggggtc gcgctggcgc cgccgatcaa ggagcgcgcc atcaccggcg
     6781 ggaccgtcgt ggggatgacc gtggcggtgg cggggacgac gttcctgacg cggctggtgt
     6841 tcccggctcg cagcgggcag gtcggggacc tgcacctgtg gtggtggccg cagtgcctcg
     6901 gcatggtgct gctgggggcg atcggggggc gcaagctcgc tgagcgggtg ccggacgaga
     6961 tctaccgcat gacgcgcaac gtcgtcatcg gcacgatcgc gctcctgccg gtcgcggcgg
     7021 cgatgatggg tgtgctggat ctggcgaaga gtgcggagcc gttcctcggc ggctttcggt
     7081 ggcaggcggc ggtgctggcc ctcgtcgagg ggatcctcgt ggtggccggg agtttgtggc
     7141 tcatcgggct ggctcagcgc aggctgacgc gccagggtcc gttcgtggac gggctggcgc
     7201 ggtcggctta cgtcgcgttc gtggtgcagg ggccgatcct gctcgcgctc gccacggggt
     7261 tgcggccgtt ggaccttccc gccgaggtga aggcgccgtt ggtggggatg gcggcgatcg
     7321 tgctgtcgtt cgggatcggg tgggtggtca cctcacgccg aggcgcttca gcacgctcgt
     7381 cgtgatgccc gcggcgtcga ggccgtgggc gcggaggatg cgtgcgcggg agtcgtgggg
     7441 caggaaacgc ggtggcaggg cgaaggtcgc cacgcacacg gacgtgccgg tcagggcttg
     7501 gccgaggcgt gctcccaggg cgccagtcga cgtcgtgtcc tcgacggcca ggacgaggcg
     7561 gtgccggccg ctgtacttga ccaggtgcgg gtccagcggt gcggtccagc gcgggtccac
     7621 cacggtgacg cggacgtcgt gcgacgccag ttcgtccgcc gcggccagac acgcacccgc
     7681 cagcgggccc acggcgacga ggagcacctc ggcgtccggg tcctcgcgca gcacgtcgaa
     7741 gtggcccacg cggcggaccg cgggcacgtc cggtcccacc gcggctttcg ggtagcgcac
     7801 gaccgtgggg ccgtccgcca cctcgacggc ctcgcgcagc agtgcggcca gggacgccgg
     7861 atcgcgcggg gcggccagcc ggaggccggg gacgacgggc agcacggagg catcccacat
     7921 gccgtggtgc gacgcgccgt ccgggccggt caccccggca cggtccagca cgaacgtcac
     7981 cgggagccgg tgcagcgcca cgtccatcag caactggtcg aacgcgcggg acaggaacgt
     8041 cgcgtagacg gcgaccaccg ggtgcaggcc gcccatggcc atgcccgcgg cggacgtcac
     8101 ggcgtgctgc tcggcgatgc ccacgtcgaa cacgcgcgac gggaagcgtt cggagaaagg
     8161 cctcagcccc accggttcca gcatcgccgc ggtgaggcag acgacgtccg ggcgctcggc
     8221 tccgatcgcc acgatctcgt cggagaacgc gtcggtccac gtccggccgc cggcggcacc
     8281 cgcggcgccg accgcgtgca tgcggtcggc ctcgtcggac tcggcagcgg gatacccctt
     8341 gcccttcacg gtcttgcagt gcacgacgac gggacggccg agcgacttgg cctcccacag
     8401 ggcgttctcg acggcgtgca cgtcgtgccc gtcgacctcg ccgatgtagg cgagacccag
     8461 cgcctcgaac aacccccgcg cggtgccgtc cagcaacgac gccgcgaaac caccggcggt
     8521 cgggtcgtac gagcgcccgt tgtcgttgag cagcaccacg accgggcgcg acgagccgcc
     8581 gatgttgttc agcgcctccc agcacatccc gccggtcagc gcgccgtcac cgacgatcgc
     8641 gaccaccctg cgctcggtgc cgcccagctc gaacgccttg gccagaccgt ccgcatagga
     8701 cagtgccgtc gaggcgtgcg agttctcgac gacgtcgtgc gcggactcgg ccgcggacgg
     8761 gtaaccggac atgccaccgg cctgccgcaa cgagtcgaag tccgaacacc ggcccgtcag
     8821 catcttgtgc acgtacgact ggtgcccggt gtcgaacagc accacgtcga ccggcgaggt
     8881 gaacacccgg tgcaccgcga tcgtcagctc gacggcaccc aggttcggcc cgaggtgacc
     8941 accggtccgg tgcaccttgg agatcaggaa cgaccggacc tccgacgcca gcgcaccgag
     9001 ctcggaggac gagagcgccc gcacgtccgc gggcgaggtg atgtcagcca gcacggcgca
     9061 ccgccagcgg caacgtgaac gagatcgtct ccgtcgcggt cgtgtgcgtc gacacggaca
     9121 cggaacccat ggccttcaac gcctccacga cctcgtccac cagttcggga ggggccgagg
     9181 cgccggcgga gaggccgacc gacgtcacgc cggcgagcca cgccgggtcg atctccgagg
     9241 cgtcgtcgat caggtgcgcc ggcgtgccgc cgcgggccgc gagctcgacc atccgcaccg
     9301 agttcgacga gttcttcgag cccaccacca gcacgaggtc ggactgctcg gcgacctcgc
     9361 ggatcgcgat ctgccggttc gtggtggcgt agcagatgtc gtcggaaccg ggcccccgca
     9421 cgtgcgggaa cttccgctcc agcgcctcga tcacctcggc cgtctcgtcg acggccagcg
     9481 tcgtctgcgt caggtacgac accggaccgg tgatctccag cgcgaggacg tcctccacgg
     9541 tctccaccag caccatctgg tcgggggcct cgccgagcgt gccctcgacc tcctcgtgcc
     9601 cggcgtggcc gatcagcacg atggtgtccc cgcgctcggc gaaccgccgc gcctcggagt
     9661 gcaccttcgt caccagcggg cacgtcgcgt ccagcacgtc gaggtcgcgc agccgggcct
     9721 cggcgcgcac cgcgggggag acgccgtgcg cggagaacac cgccgtggca ccgaaaggca
     9781 cctcggacag ctcctccacg aacacggcgc cacgagcctc cagcgaccgt acgacgtgga
     9841 cgttgtgcac gatctgcttg cgcacgtaga cggggccgcc gcgctggtcg agcagtcgtt
     9901 ccacgatctc gatggcgcgc tccaccccgg cgcagaacga ccggggtgag gcgagtagga
     9961 ccgaacgcgg cgggtgttcc gtcatcagtg ccttccagga tcagtgatct cggtgggtga
    10021 ccagttgggc gagcgtgccg agctccacgg ccgcgcgtgc ggtcggggac gcctcgccga
    10081 ggtggaccaa cgcctgcgtg tggagctcgt cggcctgcgt ctggctccac gcgcgaccgc
    10141 cggcctggtc gaccaggtcc gccgcccgcg caagcgtttc cgcgttcatc tcgtgctcgc
    10201 cgaagtacag cgacgcgagc tccgcggagg cggggacccc cgcgttcagg gctcgcacga
    10261 ccggcagcga cttcttgcgg ttcaccaggt ccatctgcgc gaccttgccc gtcaccgccg
    10321 ggtcgcccca gatgccgagc aggtcgtcca cgtgctggaa cgccagtccc agctcggtcc
    10381 cgtagccgcg catcgcctcg acctgctcgt cggacccgcc gccgtacagc gcgcccagcg
    10441 aggtcgaggc gcccagcagc gctcccgtct tgccgcgcga catccgctcg acctcggaga
    10501 cccgcacgtc gtcgcgcgtc tcgaagtcca ggtcgtacgc ctggccttcg agcagcgcga
    10561 cggtggcgtc gttgagcgtc cggatcgcct ccagcgtccg cgggtggccc gacgccgcga
    10621 gcacgtccag ggccagcgcc tgcaacgcgt caccggccag gatcgccgcg ttgacgccga
    10681 acacggtcca cgccgtggcc cggtggcgcc gggtcgtgtc gcggtccatc acgtcgtcgt
    10741 gcagcaacga gaagttgtgg atcagctcca ccgcgaccgc ggcgggcacg gcggagccgg
    10801 cggtgccgcc gacggcctcg gccgccagca gcaccagcgc gggacggatc gccttgccgc
    10861 cgttctcgag caccgggttg ccgtactcgt cgcgccaccc gtggtggtat tccgcgatcg
    10921 tgcgcatcgc cggcggcagc tggtcgacgg ccttgcgcag agccgggagc acgaggctcc
    10981 ggctccacgc gagcagctcg ccggacggcc gtccggcggc cagtggttcg gtcatctccg
    11041 ctgtcatcgc ctagagaccg atctccacgt tctccagcac gcccagggcg tccggcacca
    11101 gcaccgcggc cgagtagtac gtcgacacca ggtacttgag catggcgtgc tcgtcgatgc
    11161 ccatgaaccg cacgttcagg ccgggctcgt actcgtccgg gatgccggtc tggcgcaggc
    11221 cgatgacgcc ctgcttctcc tcgccgagcc gcatcgcgat gatcgacgtg gtgccgttct
    11281 tgttgaccgg gatcttgtcg cacggcgcga tgggcacgcc ccgccacgac tgcagctgct
    11341 ggccctcgac gtcgacggtc ggcacgtaca gcccgcgctt gttgagctgg cggccgaacg
    11401 cggcgatcgc cctggggtgg gcgaggatca gcctggtgtt gcggcggcgc gagatcagct
    11461 cgtccatgtc gtccggcgtc accggtccgg agtgcgtgct gacgcgctgc ttgaggtcgg
    11521 cgttggcgag caggccgaac tccttgttgt tgacgagctc gtgctcctgg cgctcgcgca
    11581 gggcctcgat cgtgagccgc aactggtgct cgacctggtc catcggctgg ctgtagaggt
    11641 ccgccacccg cgtgtggacg cgcacgatcg tctgcgccac cgagagctcg tactcccgcg
    11701 gccgcagttc gtagtcgacg aacgtgccgg gcagcgtcgg ctccccgtcg tggccggacg
    11761 agatgtcgat ctcggcctca ccgtgcttgt tggacgtctt cgacgggttc gcgagctgct
    11821 gctcgatgtg ctcgcgcatc ggctcgatct gcccgttgag ctgggcgaag gccgcgcgcg
    11881 agagcaccac ggccgtcgtc ggcgtcaacg cgcgggcggt gaagctccag ttcttgtccg
    11941 caccggacag gacgggctcg tcaccgaggt actcgccgtc cgcgatcgtc cccagcgcca
    12001 cgtcgtcgcc gtactcgccg cggccggtct tggtgacctt gccgtgcgcg atcacgatga
    12061 tctcgtcgac ggactgaccg cggtgcgcga tcacctcgcc cggctcgtac tcgcgctgct
    12121 cgaaccggtt cgcgacggcg gtcagcgccg cttcgtcctc gaacccgcgc agcagcttga
    12181 actccgccag ctcctgcggc acgatccgca cctcggagcc cacggcggtg aaggtgaccc
    12241 ggccgtcgcc gatggcgtag gagagccggc ggttgacccg gtacgcgcca cccttcgcct
    12301 cgacccacgg cagcatgcgc agcagccagc ggggcgagat gccctgcatc tgcggcgcgg
    12361 acttggtggt cgtggcgagg ttgcgggccg cggcccggga gaggctcagc tgcttgtcct
    12421 cgatcccgag gcccggatcg gtaacagtca ctgcaggtcc tgccaatctg ttttagcggg
    12481 atgaaacgga gagtgcggcg gtgccgagtc cggtgggacg gtggaacgac gtccgggtgg
    12541 gggccgggga gtgggtgaag cgaccggatc tccgcgtcca gagcagttca ccggcgagcc
    12601 acgacttcag cgcttcggcg taccggtgca gaccggcctt cgcctccgcg tcgagcccgt
    12661 actcggtggc gagcgacggc agctcgccga tgatcgcgcc gatctgccgc agccgtgccg
    12721 cgatcaggtc ggcgacgacc gacacggcct gctgcgtctc gcagccgaag aactgctgca
    12781 cggcgagcac cgcgctggtg gtgctgccac cggtggcgta ggtgcggtcg aagccgacga
    12841 tctcctggcg cagcgcggga acgtcgccga acgagtccac cagcgcccgc atcgtgctgt
    12901 tgcgcaacag ctcctcgggc agctcggcgc cgacggaccc gcgggcgagc ttcgcggaga
    12961 gctcggtggc gatcgaccgg cggcgcatct ccacgaggtc gatcgggtcg ggcaccctgc
    13021 cctgcgcggt gttgtgcagc tcccacagca acgcgtcgag gaactcggcg aggtgctcgg
    13081 agtcgaagct gtccagcgtg gaccgcgaga cgaggtcggc aaggcctttc tccgcggggt
    13141 tcatcggcgc cgatccgctc agcaccgact tcagccccgc cacgaaggcc ttgcccccgg
    13201 cgacgtcgcg cgagcggagg aacgcctgga acgcgtcggt gacgtagaag ccccacgtgt
    13261 gccagtcgtt gatgtgcttc aggtcctcca gcgacgccgt cgggtgggtc agcggaccga
    13321 agccgccgta gtccgcggcg tcgtagaacg cctcggtcca cggcacgcca ccgagcatgc
    13381 ccatgtcccg cacccacttc ttcgtgtgcc ggcggacgcg gtcgacgtgc ggggagagcc
    13441 ttgccgcgaa gggcatgtcg aacgagggga cctcaaccac gggacacccc cggccaggcc
    13501 gcggacgtgc cgaggccggt cggcccccgc aggatcgtgc ggaagaacgc cgagttcccg
    13561 gctccgccct cgaccttggt gtagcggccg gcgtgcaggt gccactcgtg gccaccggac
    13621 tgccagtcct gcaacccctt cacgtacttg agcacgcgcg cctggtcctc cgggcccagc
    13681 gagttctcgg cgaacagctg cggcagctcg gtgaacacgg tgttctcgaa ctggtgcagg
    13741 cgcgaggtca gcagcgtgtt cacggcctcg acggcggtct gcgtgtcgtg gccgaagaac
    13801 ttctcgaaca cgagcacccc gttggagttc tcgccctccc gcagcacttc ccgctcgtac
    13861 gagaagatgt cgttgcgcag gtggatcgcg tcggagaacg tgtccgacag cacgcgcagc
    13921 gggcgggtgc ccgcgacgga cgcgggcacc tcggcggctt cggagacctc caccaggttc
    13981 gccgaccacg gcgcgccgcc gaccttgcgg cgcatctcga tgtactcgat cgggttggcg
    14041 accgtgccgc tctcgatgtt cttgatctcc cacatgcact cgagcagcag gttgtgggtg
    14101 ctcgtggtga accggcgccg ccagtcctgc gacatcagcg ggatcgtccg ctgccacagg
    14161 tcgacgagac cgcgttcggt cgggttccgc ggctccggcc acgggtccgt gccgttcagc
    14221 ggcatgaacg ccggcaaccg gtcgaggtag gccctggcac cggccacgtc cttgccctgc
    14281 ttgaactccg cgaagaactc gtcgtcgaag tagaagaccc agacgtacca gtccgtgatg
    14341 aggtcgagga cctccgcggg cgcgtccggg tgggtccacg cgcacatgaa cccgtagtcg
    14401 tcgcccgcga ggacctcgtc ggtccacacc ccggtgtcga gcatccccat gtcccgcgcc
    14461 cactgcgtgg agtgggcgcg ggcgcgttcg aggtgggggt tcatccgcgc cgggtgcggc
    14521 acgtagaact ccggcatggt gaaggacgcc aacgctgtca gccctcgcgg ccgagctcga
    14581 cgtgctccag cacgccgatg gcgtccggca ccatgatagc ggccgagtag taggcgctga
    14641 ccaggtagtt gatgatcgcc tggtcgttga tgcccatgaa ccgcaccgag agaccgggct
    14701 ggtactcgtc cgggatgccg gtctggtgca ggccgatgac gccctggttc tgctcgccgg
    14761 tgcggatcag catcaccgac gacgtgcggg tgtcggagac cgggatcttg ttgcacggca
    14821 ggatcgggat gccgcgccac gcgggcacct gctggccgtt gaagtcgatg tgctgcgggt
    14881 acaggccgcg cttgttgagc tcgcggccga acgcggcgat cgtgcgcggg tgcgcgacga
    14941 agtacccggg gtccttccac acgatcgaca gcagctcgtc gaagtcgtcc gggctgggcg
    15001 ggccggaacg ggtgtggatg cgctgcttga ggtccgcgtt gtgcagcagg ccgaacgacc
    15061 ggttgttgac gatctcgtgc tcctggcgct cgcgcagggc ctcgatcgtg agccgcaact
    15121 gctgctcgac ctggtccatc gggttgttgt agaggtccgc gacgcgggtg tggacctgca
    15181 gcacggtctg ggcgacgctc agctcgtact cgcgcggcga gagctcgtag tccacgaacg
    15241 tgccgggcag cacgggctcg ccgtcgtggc cggaggacag gtcgatctcg gcctcaccgt
    15301 gctcgtcctg cggcttgttg cggctgttga aggtgtgctg gatgtgtgcg cgcaggccgc
    15361 ccgcttcccc gttgagcgcc tggaagtcct cccacgagag cgagagcacg gtgaccgggg
    15421 tgacggcctt ggcggtgaac tcccactcgc cctgcggccc cgccagcacg gtctcgccga
    15481 agtactggcc gtcggcgagg ttgccgagca cggtctcgcc gccgtactca ccggtgccga
    15541 ccttgtcgac cttgccgtgc gcgatcagca cgacggtgtc cttcgggcgg cccttctcga
    15601 cgatgacgtc gccgatgccg aactcctgct ggcggaaccg gccggccagc gcggcgagga
    15661 cctcctcgtc gtcgaagccc ttgagcagcg cgagttcggt gagctcctgc ggcacgacgc
    15721 ggatctccgc gccgatgttg gtgaacgaga cgcggccatc gcccagcgtg taggtgagtc
    15781 ggcggttcac tcggtacgca ccaccggccg cctgcaccca cggcagcacc ttgagcagcc
    15841 agcgggagga gattccctgc atctgcggga cggacttggt ggtagtggcc agatttcgtg
    15901 cggcggccgt gcccaaactc agctgctgac ggccctcatt gaggtcagaa tccgtcacag
    15961 tcacaaccgg tacccaccta tctcaatgcg ctaatggacc aatccgataa gccggaaagg
    16021 acgttagttc gcggaattga gagctgtgaa ggggccaaaa aggcgtcatt cgggtgggtg
    16081 gcttgcgcct ggtggggcta cggagcgtac aactgctgcc ggatgcaacc tttcttgtat
    16141 cggcaggcgg gtgatcgccg actattcgtt cactgatgga atcgggcact cgtttggctc
    16201 agtaggatca ctctttcgtg cacattgtca gggttggtgg tgatgttatg agatgccact
    16261 tcgagcggac cgaaatccac tcgaagtggt gggcatcaaa ttgccgcaac gactattggt
    16321 gtcattgcgc gtcgcgcgag ttcaggaatg attccaactg gtcgacgacg aacgcgtggt
    16381 cctccgcctg ggggagaccg gacaccccga ccgtgccgac cgggccggtg ccgcggacga
    16441 cgacggggaa cacaccgccg tgtgcggcgt acaggtcggg gtcgaggcgc gactccgcct
    16501 cgaacgtcgt gcccttctcc cggaactccg tgccgacgta gaacgagctg tgcccgaaca
    16561 gctcgaccac gcgggccttg cgctcgagcc acctgtcgtt gttcggcgac gtgccgggca
    16621 gcgcggcgtg gaagagccgg tgaccgcccc gccgcaccga gatcgcgatc ggcaggccct
    16681 gttcgcgggc ggcgtcgagc aggtgcaggc cgagctcgat cgcgacgtcg ttgccgaacc
    16741 ggctgaactg gagccggcgt tcctgggcga ggagttcctc ggagttcaca gctgcaccac
    16801 ccggttctcg cgtgcggaca tgaaagcggc ctcgatcacc cgcagggcgg ccacggctcc
    16861 ggccgggtcc acggggatcc ggccggcctg cagttcggag tagaagtgct ggtaggcacc
    16921 gggttccacg gcgacctcgg tggcccggtc gagaacgccg agcgtgccgg tgcggtcctc
    16981 gtgaccccag ccggagtcgg tcgggcggcg cccggccgcg agcgcgtcct cctgctcgtc
    17041 gaggccgctg atctcgaacg cgccctcgct gccgagcagg cggaaccgcg gcccgtggtg
    17101 tgccgcgtgc gcgttggccc acaggtggga gcggacaccg ttctcgtgcg tcagcgcgac
    17161 gaacacgtcg tcgtcgacct gcacaccggg gcggcgcagg tcgagttcgg tgtagacgct
    17221 cctgaccggc ccgaacagct gcagcgcctg gtcgacgagg tgcgcgccga ggtcgtagag
    17281 caggccgccc gcctcctcgg gggcgccgaa ctcgcgccag ttgtcccaga cctccgggat
    17341 ccagcgctcg aagcgggact cgaaccgccg cacctcgccg agctcgccca ggaccttgcg
    17401 cacggtgagg aagtcgctgt cccaccggcg gttctggaag acggtgagcg gcacccccgc
    17461 ggcccgtgcc gcggccagga gttcggcggc ctccgcggac gtcggcgcga acggcttgtc
    17521 gacgacgacc gcgacaccct gggcgatggc gcgcttcgcg tactcgacgt gggtcctgtt
    17581 cggcgtcgcc acgacgacca ggtcgaggtc cagctcgaac agctcgtccg ccgtcacgat
    17641 cttcgcgtcc gggtgcgcgg cacgggcctg cgcctgccgc cgcgggtccg aggtgacgat
    17701 cgcgacgagg tccatgccct cggtggagga gatcagcggg ccgtggaaga cccgccccgc
    17761 tatgccgtag cccagaagtc cgactcgagt catgcttccg attaaagcaa cgctgttgaa
    17821 taattgcgac cgtggacctc acctcactgc gctcgcacaa cgacaggaca gtgctccggc
    17881 tcgtccgctc aggggccgtg agcagggctt ccatcgccgc ggaggccgga ctgaccccgc
    17941 aggcggtctc gaagatcgtg gcgaggctca tctcggcggg cctgctggag gagaccggcg
    18001 ccgtgcgcga cggcggccgg ggcaagccgc ggatgtcgtt gcggctcgcc gcggacgggg
    18061 cccacgcgta cggcgcctac gtcgaccgcg acgagctgcg cgtggtgaag ctcgacctca
    18121 ccggcgaggt ggtgtcgtcg gcggtcgcgc cgctggcccc gatgttcact cccgccgacg
    18181 tgctggacgc tctggagccg ttgatctcgg tcgacgagaa ggtgctcggg ctcggcatcg
    18241 gcatcgccgg tccgctggag cacggcgaag gcgtggtgtc gccgaacggc ctgccgggct
    18301 ggtcctcgat cccgttgaag gcgctggcgc aggaacggct gggcctgccg gtagtcgtcg
    18361 acaaggacac caacgcggcc gtgctcgccg aggcgtggcg gcggccgatg cgggatgcgg
    18421 cgctcgtgtt cgtcggcacc ggcctgggtg tcgggttgct gctcggcggg gaggtgcacc
    18481 ggggcgcgcg gtcgggggcg ggcgagttcg ggcacacgac gatccagctc gacgggccgt
    18541 tgtgcgtgtg cggacggcgc gggtgcgtcg aggcggtgca cgcggccgcc aaggacgacg
    18601 aggcggcacg ggtcctcgcc gccgcggtca cgaacctggt gcagctgctg gacctcgacc
    18661 agatcgtcct gagcggacgg aaggtgctgc ggtcgccgga gctgtacctg cgggcgatgc
    18721 ccgatgtgga cgtgagcgtc acctcgtacg ggcccgacct ggtgccggtg ggcgcggggc
    18781 tgctggttct cggcgaactg ttttagcatc gggggtgtgg acgtcgagca cgtcgtcggt
    18841 tcgccgcacc cgcggctgcg gccgttcgtc acgcggtact ccgggtatcg gatgcgcacc
    18901 gagcccggca tccaccgcgg cctgccgtcg cgctccctca cgctcgtggt cacgctggac
    18961 ggcacggtcg acctggcgga tggccgattc gccacgctgt gcggcggcct gcacgacgag
    19021 gccgtgatca tcacccacga cgggttccag cacggcgtcc agtgcgacct cacgccgctg
    19081 gggatgcggg cgttcttcgg cctgccggcc ggtgagctct ccggggtgac ggtcgggctc
    19141 gactcgctcg acgccccggc cgcggagttg cgcgagcggt tgcggcacgc ggcgacgtgg
    19201 acggaccgct tcgcgttgct ggacctggtg ctcgggcggc tcgtgcggcc ggtgcggcag
    19261 caggtcgagg tggcgtgggc gtggcagcgg ctcgcggcgg gggtggcggt ggccgacatc
    19321 gccgccgagg tcgggtggag ccgccagcac ctcagcgcgc ggttcgcggc ggagtacggg
    19381 ctcacgccca aggtcgtggc gcgggtgatg aggttcgagc gggcgaaccg gatgctgcgc
    19441 ggtgagcggc ggccgacgtt caccgaggtc gccgccgcct gcgggtacac cgaccaggcg
    19501 cacttcaacc gggactggcg cgcgctcgtc ggggcgaccc cgagcgagtg gatcgcggcc
    19561 gagcttccat tcgtacaagg cggtgagggc ggtgcgggcg cagagttggc gccatgagca
    19621 cacctgcacc cacctgctgg ccctgtttgt cctatcggga cgctcccgcc gcgatccgct
    19681 tcctggtgga ggcgttcggt ttctccgagc acctcgtcgt tccgggtgag gccgacggcg
    19741 aggtcgtgca ctgcgagatg gtctggcccg agggcggcgg cgtcatgctg ggctccgccg
    19801 tgcggtcggt cggcgaggtc gaggcgacca aggccggcgc cgggtccgtc tacgtggtga
    19861 ccgaccggcc cgacgagctg cacgcgcagg cgctcgcacg gggcgccacc gaggtccgcg
    19921 ggctgcgcga cgaggactac ggctcgcgcg gcttcaccat ggccgacccc gagggcaacc
    19981 gctggagctt cggcacctac cgcggggcgt gacgcaacct ttacgcgctg tttcgagtct
    20041 tccccgttgg agaggttcac acctagggga ggacacgtgc gcttagcacg atgtttggtg
    20101 atcaccgctc tcgccgccgg actgctgagt ccggcggcga cggcgcaggc ggaaccggtg
    20161 agaacgcaga agacctcgac catcacgttg atcagcggtg acaaggtcgt ggtcgacgaa
    20221 cgcggcggtc tcgtccgcgt cgaggggcgg cccggcatgt cgttcgcgca gtacgtgcgc
    20281 gacgaccacc agtacgtggt gccggcggac gcggtcgacg cggtggcgca gaacagcgtc
    20341 gaccagcgct tcttcgacgt cacctcgctg cactcgtacg gctacaccga cgagaggacc
    20401 gaccggatcc cgttgctgac caacggcttc cgcgcggctg ccgcggtgga gaagaaggat
    20461 gccgcgcagc agtggacggc ccggcgcacc agcgcgtcgc gtgccgggaa gctgtggctg
    20521 gacggcaagt cgaagatctc gctgaccgag agcgtgccga tggtcggcgc gcccggcgcg
    20581 tggcaggccg ggttcgacgg caccggcgtc accgtggccg tgctggacac cgggtacgac
    20641 cggaaccacc ccgaactcgc gggcgtcgtg tccgtcgcca aggacttcac gccgtccggg
    20701 atccaggacg acatcgggca cggcacgcac gtcgcggcca cggtcgcggg gcgcggcagc
    20761 cggcacgtcg gcgtcgcgaa gggcgcgtcg ctggcggtgg gccgggtctg cgaggccgag
    20821 tggtgcctcg acagcgcggt gatcgccggc atggagtggg cggcgcgcga ggtgaaggcc
    20881 aaggtcgtca acctctcgct gggcggtgac cagtccgacg gcaccgaccc gttgtcgttg
    20941 aaggtcaacg agctcaccgc cgagaccggc gcgctgttcg tggtggcggc gggcaacgcc
    21001 ggcacccggc ggcaggtctc cggtccggcg tcggcggacg ccgcgctggc cgtggcgaac
    21061 ctgaccaagc agggcgtgct ggaggagtgg tcgtcgcgcg gtccgcgggt gggcgaccac
    21121 gcggtgaagc cggacatcgc ggcgccgggc acggacatcg tggccgcacg cgccgagaac
    21181 acgttgtggg acttcgcggt cgacgacctg cacgcacggc tgacgggcac ctcgatggcc
    21241 gcgccgcacg tggccggcgc cgccgcggtg ctcgcgcagc gcaacccgtc ctggaaggcc
    21301 gccgagctga aggcccacct gatggcgacg gtgaagccgg tcgcggacaa gccctcgaac
    21361 gtcggcaccg gactgctcga cgtcgagcgc gcggtgacgc agcaggtgcg cgcgtccgtc
    21421 ggcagcctgt ctttcgggct gctggaatgg ccgcacacca ggacgttcac gaagacgatc
    21481 acctacacga acgcgggcgc cgagccggtg tcactgacgt tgcggcacga cctgggcgcg
    21541 gacttcgcgg tgccgtcgtc ggtgaccgtg cccgccgggg gcagtgcctc cgtcgacgtg
    21601 gtgctggacc cggccaaggg gctcggcaag ttcttcgggc acctgaaggc ctctgctccg
    21661 ggtgtgtcgg tggtgaccgc cgtcggcgcg tacgtcgagg aggagcacca cacgctgaac
    21721 ctgtcgatga tcggccgtga cggcaagccg gtcgcgagcg agttcgtcgt cgtggtcgac
    21781 ctgtccacgc gggaagcctc ggtggtcacc atcgagaacg gcacgggcgc ggcgcggttg
    21841 ccggtcgcgg actacgcggt gatcggccgc atcgacgagc tgacgccgaa ctacgcctgg
    21901 ttcaccccgg tctccgcgac cgaggtggcg ggccgcgtgt cggtgcgcgc ggacgtgtcc
    21961 ctgaccctgg acgcccggca gggcaaggag atccgcgtcg agctccccga gcgcgactca
    22021 caggtgtggt accgcgacgc ccggctgagc gtgccgttcg agtcggacag gatcagcagc
    22081 atcgcgagca cgatcgacgg ccgggttccg ttgtacgggc tgtccttcgg cccgccgctg
    22141 cccgagctga cctacgactc cgggctcaag ggcggacagc cgctggtctc ggtcgtcggc
    22201 gggttcccgg tgcgctacta cgacggcagc aggttcctgc cgcccggtga gcacgagctc
    22261 gacgtggccg agcgcggcac cgacgtgcgc ggcaagctcg ctctcgtccg ccacgccggt
    22321 gagaacccgt acgaggtcgc gagggccatg caggacgccg gggcggtcgc cgtgctgtgg
    22381 gcgggaccgg tgccgttcgg gtcggagcag cagacggcga tcccggtgat cgcggtggcg
    22441 gagcaccacg tggcggtgac gccggcgaag ctgacgttgc gggccgtcgc gggctcgccg
    22501 gtgtcgtaca cgttgttcct gcgggacaag ggcgcgctgc cggtcggggt gaagaaggtc
    22561 cggcactcgg agctcgccga ggtgaaggcg cgctaccaca cgtccggtcc ggacggttcg
    22621 gtcctgcagc ggaactcacc ggtcgtgaac ggcgtgctcg gcagggtgct ggacgaacgg
    22681 ctctccgctc ccgcgcagcg caccgagtac ttcacgccgg ggatctcctg gtaccaggag
    22741 gggttcgacg gccgcagctc cggcgcgggc gacgacccga gcacgacgtc gtgggcggac
    22801 ctcgagcccg tgacgttcca ggcgggccgg aagtacgagc ggacccacct tcgcgggatc
    22861 acctcaccac ggctcggcgg gtcgtccgtc gtcacgtggg cggacggcgg cggcgtcgaa
    22921 cggtcgggcg acctcatcaa cgcccgcatc tcgccgttcg gcggctccgg ctgggtggag
    22981 aactggcgcc aaggcggctg gggcacgctc gagctgcggc acgacgacgc cacgctcggg
    23041 tattcggacg tccggcgggg atcgttccac gcccccgccc gcgacggccg gtacaagttg
    23101 ctgctggacg cctcccggga cgggctggcg ttgtcgacct cggtgcggac gacgtgggag
    23161 ttctccgcgg cctccgacgg ccggctgccg ctggtcgagg tcgactactc ggtgccggtc
    23221 gacctgcgca acagctggaa ggcggggctg gcgatgccgg tgaagttcac cgcgtcgggc
    23281 ggcgcccgag tgctggaggc ctacgcgtcg ttcgacgacg gtgccaattg ggtgccggtg
    23341 aagtccgtcg ttcccccagg cgggaaggca ggcggttacg tgtcgctccg cgtggtggcc
    23401 cgtgacgccg ccggcaactc ggtagaccaa acggtcctgc gcgcgtaccg ccttcgggcg
    23461 taaccgggcg gctgtccggt cgttgtaccc acctgcggca cctgccccgc cgagcgcgag
    23521 acgatccagg gacgcggcgt ctccgcgccc agggcaggtg ccgccattct cggtggccgg
    23581 tccggcgtgc ctgtggtggc atgtcggccc atggggactt tcgaggaact ggtggccgag
    23641 ggcgcggccg tgccgctgga gggctgggac ttctcctggt tcgagggccg cgccaccgag
    23701 gaacgcccgc cgtgggggta cgccggcctg atcgccgcac ggctcgcggt cgtgtccgcg
    23761 gcgctggacc tgcagaccgg cgggggagag gtcaccgcgt ccgcgcccgt cctgccaccg
    23821 cggatggccg ccaccgagtc gtggccgccg aacgccttgg tggcctctcg gcgcctacct
    23881 ctcgtcgtgc tggcggccga cgcggggccg ctgccgttcc gttcgtcgtc gttcgatctc
    23941 gtgatctcgc ggcaccccgt cgtgacgccg tggggtgaga tcgcgcgggt gctgaggccg
    24001 ggcgggacct acttctcgca gcagatcggg gccgggacga accgggagct gacggacttc
    24061 atgatggggc cgcagccggt gagtccggct cgcagcgtcg aggtcgcccg tgcggaggcc
    24121 gaggcagccg ggttggaggt gctgcggctg gagcccgtgt ggctgcgggt ggagttcttc
    24181 gacgtcggcg cggtggtgca cttcctgcgg aaggtgttgt ggaccgtgcc ggggttcacc
    24241 gtggagaggt atcgggaccg gctcctggac ctgcacgcgc acatccagga gcacggcgcg
    24301 ttcgtcagca cctcgacccg gttcctggtg gaggcgcgca agccttaggg cgtgtgtcga
    24361 agtccgatcc gcgacagccg ggcccgaggc ggcccctggc ggcacggccg gaacgcccac
    24421 gtacaacacc ggcacgcggc cgttccggcc gcaccaccag gaaccacctc aagcgcgact
    24481 ctcatcgaac cggacttcga cacacgccct aatcggtgag gtaggaccgg tagaggt
//
