LOCUS       NZ_CP099468            21758 bp    DNA     linear   CON 04-JUL-2024
DEFINITION  Streptomyces phaeoluteigriseus strain Qhu-M197 chromosome, complete
            genome.
ACCESSION   NZ_CP099468
VERSION     NZ_CP099468.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces phaeoluteigriseus
  ORGANISM  Streptomyces phaeoluteigriseus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
REFERENCE   1  (bases 1 to 9026270)
  AUTHORS   Zhang,B., Xiang,X. and Fan,J.
  TITLE     Complete genome sequence of soil microorganisms Streptomyces sp.
            Qhu-M197 isolated from Alpine meadows habitats on the Tibetan
            Plateau
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9026270)
  AUTHORS   Zhang,B., Xiang,X. and Fan,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-JUN-2022) Faculty of Eco-Environmental Engineering,
            qinghaiuniversity, No. 251 Ningda Road, Chengbei District, Xining
            City, Qinghai Province 810000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: Hifiasm v. v0.14; Circlator v. v1.5.5; Pilon v.
            v1.22
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 68.51291x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023923245.1-RS_2024_07_04
            Annotation Date                   :: 07/04/2024 06:06:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,100
            CDSs (total)                      :: 8,006
            Genes (coding)                    :: 7,707
            CDSs (with protein)               :: 7,707
            Genes (RNA)                       :: 94
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 299
            CDSs (without protein)            :: 299
            Pseudo Genes (ambiguous residues) :: 0 of 299
            Pseudo Genes (frameshifted)       :: 130 of 299
            Pseudo Genes (incomplete)         :: 241 of 299
            Pseudo Genes (internal stop)      :: 34 of 299
            Pseudo Genes (multiple problems)  :: 90 of 299
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:40:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4270760
            Orig. end                         :: 4292518
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP099468.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21758
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="19"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21758
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21758
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11758](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11758)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(232..248)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.32"
                     /tool="antismash"
     misc_feature    859..872
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
     gene            1258..>1791
                     /locus_tag="NFX46_RS18890"
                     /old_locus_tag="NFX46_18890"
                     /pseudo=""
     CDS             1258..>1791
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004921061.1"
                     /locus_tag="NFX46_RS18890"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="NFX46_18890"
                     /product="HNH endonuclease"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVQRAAPAIVNVREAFRHWNTGANPSDGCNTRAEVLISEAVAPHG
                     RTQLPSDGRELVVVLRPGVGDVSLRFGHRPHGAPRRELLTAVRRRGRRGAARRTPTTRA
                     RPPSWSPAAPARTGPRRTRIPLSGCPLAAACTADTSPSGTQRSSAGVSRPDEAEVAALR
                     EVTAGCTDESVTYEP"
     gene            1853..2463
                     /locus_tag="NFX46_RS18895"
                     /old_locus_tag="NFX46_18895"
                     /pseudo=""
     CDS             1853..2463
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325662.1"
                     /locus_tag="NFX46_RS18895"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_18895"
                     /product="isochorismatase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSRGLIVAGNRRNDFCEGGSIPVPRGARIATKIADLVEQTAGRGY
                     QYIVATRDHHIDPGGHFSQTPDLKDSFPVHFVAGGEGSEFHPHFAPATSPPPSPAAKST
                     PSSTKAPTAPPRAASKEPTKKEPP"
     gene            complement(2620..3135)
                     /locus_tag="NFX46_RS18900"
                     /old_locus_tag="NFX46_18900"
     CDS             complement(2620..3135)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123677.1"
                     /locus_tag="NFX46_RS18900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_18900"
                     /product="hypothetical protein"
                     /protein_id="WP_252550812.1"
                     /transl_table=11
                     /translation="MYKVLLDAELSKAFDVWSGYLNARTGEDDQVRARLRSTLHSARAA
                     AAEGDPASARALVAEMYDDAREAGLPWAPVRPGPCAADRQARDYAKDELRQVLPVQLRE
                     DLDSIALYLRVTGRRLQTAPGLDATTRQDILYISARAGMALDLAHPTAARRELERLKAI
                     ARRCGVEP"
     gene            complement(3382..3711)
                     /locus_tag="NFX46_RS18905"
                     /old_locus_tag="NFX46_18905"
     CDS             complement(3382..3711)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NFX46_RS18905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NFX46_18905"
                     /product="hypothetical protein"
                     /protein_id="WP_252550814.1"
                     /transl_table=11
                     /translation="MCSCGRWFGSWRRRWVLEEASRYISLVVQAVGTQIDDTYLKALGQ
                     DHLSREQVAEALVGLKRRIKGDFFVIEQDDSKTRPSERTDPRTAHRRLPSPLSPHLCCL
                     ARASA"
     gene            3849..4154
                     /locus_tag="NFX46_RS18910"
                     /old_locus_tag="NFX46_18910"
     CDS             3849..4154
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NFX46_RS18910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NFX46_18910"
                     /product="hypothetical protein"
                     /protein_id="WP_252550815.1"
                     /transl_table=11
                     /translation="MTADAVEKLLADVCGTLARAGFDVASAGDEGSPGLRVRRDTDSVL
                     VGWVPGSELDPAGREDAVFEGIRAALRSALLAILTQAGHAVQVDRESGEVRVRLLA"
     misc_feature    4008..4010
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4336..4560
                     /locus_tag="NFX46_RS18915"
                     /old_locus_tag="NFX46_18915"
     CDS             4336..4560
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018961019.1"
                     /locus_tag="NFX46_RS18915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_18915"
                     /product="hypothetical protein"
                     /protein_id="WP_252550817.1"
                     /transl_table=11
                     /translation="MTSAPIVVHQPSRTGGRSVTVHSHGRDEILGTTFSDHDLVVFLRA
                     AGVDQPEGVLDDPRWVEWRGGRPHEWRTA"
     gene            complement(4651..5499)
                     /locus_tag="NFX46_RS18920"
                     /old_locus_tag="NFX46_18920"
     CDS             complement(4651..5499)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007381822.1"
                     /locus_tag="NFX46_RS18920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_18920"
                     /product="RNA polymerase sigma factor SigF"
                     /protein_id="WP_252550818.1"
                     /transl_table=11
                     /translation="MVTDTAVTTADAKCADLPEVADPSRVAPKDARELTRLFFQQLDRL
                     EEGTPEYQYARNTLIEMNISLVRYAASRFRSRDQEEMEDIVQVGVIGLIKAIDRFELSR
                     EVEFTSFSIPYIVGEIKRFFRDTTWAVHVPRRLQEARVQLARATEELSSRLGRTPTVAE
                     LAQLMNLDEEEVIEARLASNGYRSSSLDAAIGNSEDGESALADFIGNEDGALELVEDFH
                     ALAPMIADLDERSRKILHWRFVEELTQAQIGERLGVSQMHVSRLLSRTLAQLREGMLTT
                     H"
     gene            <5713..6506
                     /locus_tag="NFX46_RS18925"
                     /old_locus_tag="NFX46_18925"
                     /pseudo=""
     CDS             <5713..6506
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020130118.1"
                     /locus_tag="NFX46_RS18925"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="NFX46_18925"
                     /product="alpha/beta hydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="RRNNVTVTGNPRGGGRWCWLTGSAVIRTCGG"
     gene            6506..7807
                     /locus_tag="NFX46_RS18930"
                     /old_locus_tag="NFX46_18930"
     CDS             6506..7807
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005315887.1"
                     /locus_tag="NFX46_RS18930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_18930"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_252550820.1"
                     /transl_table=11
                     /translation="MCPAGQQPDPHGTSEERTANAAFAALLEDSAEELYESAPCGYLST
                     LMDGTIAKINTTLLDWLGLEREAVVGRKRFTDLLTVGGKLYHETHFAPLLRMQGKIGGI
                     ALEIKQAGGARMPVLISSVVKHGGSGEPLLIRTTIFDARDRRTYEQELLRARNAAEEAR
                     KQAEADRARLQDALAVLQQSLLPATLPHVPGVEAAVHYRTASPDQLGGDFYDLFPLDNK
                     RFAFFLGDVCGKGPQAAAVTSLTRYTLRAAALHDPDPDPVSALTTLNTALHGRYTGSGD
                     ARYCTVIFGILEPDPVTGQITVRLAAGGHPPALILRAGGAVDFLPTPGGFLVGALPDAR
                     FATATTVLAPGDTLLLYTDGLTEARTGKDRTTLYGDEALRDVTAGHAGNPPQALIQALT
                     GLLDDFGDGLDDDTALLALGIPTPTPDPRTENTA"
     gene            7804..8142
                     /locus_tag="NFX46_RS18935"
                     /old_locus_tag="NFX46_18935"
     CDS             7804..8142
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005315884.1"
                     /locus_tag="NFX46_RS18935"
                     /note="This anti-anti-sigma factor, or anti-sigma factor
                     antagonist, belongs to a family that includes characterized
                     members SpoIIAA, RsbV, RsfA, and RsfB; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="NFX46_18935"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_252550822.1"
                     /transl_table=11
                     /translation="MSPLKITTRDAMTGPVLEIIGELDYTSASELPHLLTTIPLQPGQR
                     LVLDLAGMEFCDSSGISALIAARNRAHTAQADIALAAVLAHTLRVLRIVGLDQIFSLHP
                     DSDAATQP"
     gene            complement(8399..9706)
                     /locus_tag="NFX46_RS18940"
                     /old_locus_tag="NFX46_18940"
     CDS             complement(8399..9706)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="NFX46_RS18940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_18940"
                     /product="cytochrome P450"
                     /protein_id="WP_252550824.1"
                     /sec_met_domain="p450 (E-value: 6.6e-38, bitscore: 129.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEKLPLKPLPAPAVMPIMMGRFLSGPHYMERHFARHGTIVPDWA
                     PGVRAVWLRDPRLIEQVLHSSGVEHNTTGRLLGRVMGSTAMLNQLSGAQHHAVSRLMIP
                     TLRGDALSGNRAAIAVAAQRMANACPVGRPFRLLPLLDIAVAEANVRACLSVDDPRLLH
                     TWVKAIARLRQTTVRPAVMAYAVGMLPWWPTGHRAWNACLHLVRGEVARRRRTGTIHND
                     VLGILLASDSELLTDAVLCDQIAFYLLAAQAPALVAAWVIERATRTPHVWQRLVEEASG
                     QDDSAPYTDAVIREALRLRPPVTAIPWLLREPCDIGGYHVPAGTFAVASLWDLHRNPEL
                     YPDPEEFRPERFLGNRPPRGAWLPFGTGTHACIGGQLAFLQVTVLVHTLIRRGQLLPAT
                     RQDEGIGHRASTEPYPAQGCQVTLRPVRGRHPQGAR"
     gene            complement(10001..11758)
                     /gene="uppS"
                     /locus_tag="NFX46_RS18945"
                     /old_locus_tag="NFX46_18945"
     CDS             complement(10001..11758)
                     /EC_number="2.5.1.-"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="uppS"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003990021.1"
                     /locus_tag="NFX46_RS18945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_18945"
                     /product="polyprenyl diphosphate synthase"
                     /protein_id="WP_252550825.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.6e-18, bitscore:
                     65.8, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 2.2e-05,
                     bitscore: 22.6, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVGDDPALQAAYLLCRARTKQQDPAEYALIQLVPAVLRPACWALW
                     TAANALDDLADDRTAESEERAARVGEWISALDHELATGTSTDPIRLALVDTAWRWRLDI
                     SQLHNAMTLVQHDAHGRQFTDWSSWRAWGRGNLLPWFDQVRDLFDRAGVAVTLRLDRQD
                     VYEQFLDGVRLTDILTDLSADLAQGDLLLPGQSLDQFPGSADDLEQRRWSPSTAGLITD
                     LTGLARRWVTQPALTRGMHPGLATVLDTMADLLRAQLDAVSAAGPTLFHAPPRPSFVTT
                     ARLLAPARARAALAWSLTEVTVPPPRRPRHDTVLTQRPRAQRPAFRSPPPHPSGERPPQ
                     IPVDQMPTHVAVIMDGNGRWAQQRGLPRHEGHRTGRSAAYEMVYGALEIGLRHLTLYAF
                     STENWKRDDEEIGTILALLHQELREYPLEDLDVRVRWHGRPDRLPQDVIDLMRMRESST
                     RDRSGLTLTTCINYGGRDEITRTATALARRVRSGQLDPDLISETDVAQHLPQPDMPDVD
                     LLWRTGNEQRISNFLPWHTAYAELYFTADYWPETDRRHLWQAISEYTRRQRRHGAPLTA
                     VVSHEPQQP"
     gene            complement(11897..12721)
                     /locus_tag="NFX46_RS18950"
                     /old_locus_tag="NFX46_18950"
     CDS             complement(11897..12721)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018552850.1"
                     /locus_tag="NFX46_RS18950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_18950"
                     /product="ABC transporter permease"
                     /protein_id="WP_252550827.1"
                     /transl_table=11
                     /translation="MREQVMLLVTATRYAVAEHARNRFAAVLIAVFLPVWTLLAYVSMP
                     DGPVRVRLQATGELLTPHGNELTAVSGALNAVTLITGFLMFAATFNGSQFDRRLVMAGY
                     PRPHLIAAKLAGLALASALVAAYATAVMYLAWAPRQPALLAAALFSAGLTYGVLGVGFG
                     ALLRKEVEGMFAIVMTSVVDIALQNPISSSSADSAITHYLPSYGAMQAATAAAFSSTSA
                     TGYLLIELTWFAAAALLCLLTFQWRTRSALPSTPVLDAAEPGPAARLTLPEN"
     gene            complement(12718..13323)
                     /locus_tag="NFX46_RS18955"
                     /old_locus_tag="NFX46_18955"
     CDS             complement(12718..13323)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011026862.1"
                     /locus_tag="NFX46_RS18955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_18955"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_252550828.1"
                     /transl_table=11
                     /translation="MEVVDVHHHYGKRLVLRGVDFTLPAGSLIGVVGENGAGKSTLLRI
                     LAGELRPSRGSVRHGGRFGYCPQQVVVNDALTVRQHLAFFRAAFRLDSLGYAREVMDVL
                     GFSDYLDERAGVLSGGTRQKLNVTLALMHDPQVLLLDEPYQGFDWDTYLRFWELASRLR
                     ERGRSVLVVSHLAYDTQRLDELWRLDGGRLQAQGREAA"
     misc_feature    complement(13743..13759)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.65"
                     /tool="antismash"
     gene            13834..15090
                     /locus_tag="NFX46_RS18960"
                     /old_locus_tag="NFX46_18960"
     CDS             13834..15090
                     /GO_function="GO:0004144 - diacylglycerol O-acyltransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018657.4"
                     /locus_tag="NFX46_RS18960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_18960"
                     /product="WS/DGAT domain-containing protein"
                     /protein_id="WP_252550830.1"
                     /transl_table=11
                     /translation="MTRTVMAEPAPRSDRMSRKWFDYAAAHPSTSVAIGVVALCTGDLP
                     TREEVALLVSLAVDAYPELGRHPVPRPAGSAGAPGTPFRLDRQIFEVEAASGSGQTGLR
                     AVLEQLTAEPLPEALWGVWLVHGYATGEFAVVLRGHHALFDGLLLADIIACALGAEPRP
                     TRAVAGPPPRRGAYAAALREARALFRDRGRAAQPVPPSVKLTGRVQYMWEGVPVERMRE
                     AASAHRATTNDVYLAALAGALRAWAPDPQWLAGGRPVRVQVPIGYPHEAGRLGVRATAA
                     WVRLPCEVDDPAERIALVKVQTDRLRASLRNPHTGALTRLVSRFLGRFDLDLQYHPGWM
                     SMLVSHVPGPAATPAIAGRTVTAGVPLMFLPASQYLATAMCDFAGVTQLCVVADRAVPD
                     VGELAQQWVHQVGLLGGHE"
     gene            15087..17393
                     /locus_tag="NFX46_RS18965"
                     /old_locus_tag="NFX46_18965"
     CDS             15087..17393
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015155.4"
                     /locus_tag="NFX46_RS18965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_18965"
                     /product="MMPL family transporter"
                     /protein_id="WP_252550832.1"
                     /transl_table=11
                     /translation="MTHQGTGVDRATVDRAQAPPPRLSRSAQHRPWTTILLWVLFCGLS
                     GLLAADVSDRLVGGGFTASGAESELAQARTQERFGVADPDVLLLFRAQAGGPTGPALRQ
                     QVKSVVTAPAVTRLAEPLPTSPDGAPSLDASATTALVPLVLDGDTEEAKRRTLEELRSA
                     VRPPSAVTLSYGGPIAFLDEASSRSQADLVRAELLAAPLLFVLLLLIFRGLAAAMLPLL
                     TGAAAVVIGMAVLRVATEFTEVSAFAVNLVSMLGLGLAVDYALLILTRYRRERRRGLTA
                     EQARAISLRTAGRTVLVTSAVVTAALAVLALFPLAFMRSLAIGGCAVVVADVAAALTLL
                     PALMAVLGPRVDAGHGPVRWSRRSGRTKRPEGERWHTLAALVARRPALWLIACTVVLLA
                     MAAPALRTTFGGIGEGTLPSSSASRRVAEEIRETFPALQPARIQAVVDLAAPPDSTAGK
                     EALRTWLGRVAALPSTPRAEVTAVRGNALLVSVGATGEPDADRRTVRALRALAPPQGGS
                     VLVGGSAATDTDMTDALSARLPLVVGLVMAVTSLLLLLVFRSVLVPVKAIVTSALSTFA
                     CLGVMTWVFQDGHLASLLGFSALGYVETTQPVVVLVVLYALSVDYELFLLARVREEYRS
                     TGDNRHAVIAGLRDTGTVITGAAALLLVVIGALTTSSVIAIKEVGVGLFAGVLIDATLV
                     RLFLVPAALLVAGRANWWPGRSPCVTGPSGIAKLPAPAADPRMNTDVQPPQPVPDGAGT
                     PGSPGTHPSRLEEKR"
     gene            17399..18373
                     /locus_tag="NFX46_RS18970"
                     /old_locus_tag="NFX46_18970"
     CDS             17399..18373
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009074792.1"
                     /locus_tag="NFX46_RS18970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_18970"
                     /product="aldo/keto reductase family protein"
                     /protein_id="WP_252550833.1"
                     /transl_table=11
                     /translation="MEFRQLGRSGLKISAIAYGNWVTHGSQIDEQGARACVHAALDEGI
                     TTFDTADAYAATKAEEVLGRALKGQRREGVEILTKVYFPTGPGANDRGLSRKHILESIN
                     GSLKRLGCDYVDLYQAHRFDPTTPLEETLRAFDDVVRQGKALYVGVSEWTADQIRAAVK
                     TAAAMGLDRIVSNQPQYSLLQRAIEEEILPLCAEVGIGQIAWSPLAQGVLTGKYLPGSP
                     PPQGSRATDPAGRPRIAHLLRDEVLDTVQKLGPVAREAGLTMSQLALAWVLQNPGVSSA
                     IIGASRPDQIRQNAAAAEVTLDADLMKTVDDLLGGVVNRAVPV"
     misc_feature    complement(17430..17444)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.32"
                     /tool="antismash"
     gene            18587..18835
                     /locus_tag="NFX46_RS18975"
                     /old_locus_tag="NFX46_18975"
     CDS             18587..18835
                     /NRPS_PKS="Domain: PP-binding (13-68). E-value: 3.5e-09.
                     Score: 28.8. Matches aSDomain:
                     nrpspksdomains_NFX46_RS18975_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049044.1"
                     /locus_tag="NFX46_RS18975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_18975"
                     /product="phosphopantetheine-binding protein"
                     /protein_id="WP_252550835.1"
                     /sec_met_domain="PP-binding (E-value: 6.4e-08, bitscore:
                     31.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANTYELTVHHLVSDFGIEPTTISPQATPAELDLDSLSLAELAVI
                     LQEQTGIRLEEVNAGTSLEEIARQIDAARADAATAAR"
     aSDomain        18626..18790
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NFX46_RS18975_PP-binding.1"
                     /evalue="3.50E-09"
                     /label="NFX46_RS18975_PP-binding.1"
                     /locus_tag="NFX46_RS18975"
                     /protein_end="68"
                     /protein_start="13"
                     /score="28.8"
                     /tool="antismash"
                     /translation="SDFGIEPTTISPQATPAELDLDSLSLAELAVILQEQTGIRLEEVN
                     AGTSLEEIAR"
     gene            18832..20088
                     /locus_tag="NFX46_RS18980"
                     /old_locus_tag="NFX46_18980"
     CDS             18832..20088
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (72-406). E-value:
                     4.8e-50. Score: 162.6. Matches aSDomain:
                     nrpspksdomains_NFX46_RS18980_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019544470.1"
                     /locus_tag="NFX46_RS18980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_18980"
                     /product="beta-ketoacyl-[acyl-carrier-protein] synthase
                     family protein"
                     /protein_id="WP_252550836.1"
                     /sec_met_domain="t2fas (E-value: 2.8e-120, bitscore: 400.7,
                     seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 2.5e-41, bitscore:
                     140.7, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSQAVAVTGVGLVTPAGIGAQATWEGMQGATSYAAPDALLAGLP
                     VDFSCAVPDWEPDRVLGRMLSRRLDSPAQMAVLAAREALADAGLSSSGWDPHRVGVIIG
                     AGTASFQHLHDVYSKILTGRHELVSPMALPRSLPSAPVCAVALDLGAQGMSFAPSAACA
                     SGAVAIGLALQLLRAGSLDVVLAGGAESGRSAISAACFSQMGALSTRHRDPSGASRPFD
                     ADRDGFVLGEGAGVLVLESLKHARARQARVYSYLAGYGSSTDAHHVTAPHPEGRGLRQA
                     LHEALVDASWTAADVDHINAHGTATRLNDHIEARVLSDVFPRVPPVTAPKGALGHAMGA
                     SGAIEAALTVLTLRHQTIPPTANLDRPDLALASLDIVTKSPRPARLHKAISTSVAFGGH
                     NAALAFHSATTESDIEMRI"
     aSDomain        19048..20049
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NFX46_RS18980_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="4.80E-50"
                     /label="NFX46_RS18980_PKS_KS.1"
                     /locus_tag="NFX46_RS18980"
                     /protein_end="406"
                     /protein_start="72"
                     /score="162.6"
                     /tool="antismash"
                     /translation="AQMAVLAAREALADAGLSSSGWDPHRVGVIIGAGTASFQHLHDVY
                     SKILTGRHELVSPMALPRSLPSAPVCAVALDLGAQGMSFAPSAACASGAVAIGLALQLL
                     RAGSLDVVLAGGAESGRSAISAACFSQMGALSTRHRDPSGASRPFDADRDGFVLGEGAG
                     VLVLESLKHARARQARVYSYLAGYGSSTDAHHVTAPHPEGRGLRQALHEALVDASWTAA
                     DVDHINAHGTATRLNDHIEARVLSDVFPRVPPVTAPKGALGHAMGASGAIEAALTVLTL
                     RHQTIPPTANLDRPDLALASLDIVTKSPRPARLHKAISTSVAFGGHNAALAFH"
     gene            20120..20341
                     /locus_tag="NFX46_RS18985"
                     /old_locus_tag="NFX46_18985"
     CDS             20120..20341
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NFX46_RS18985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NFX46_18985"
                     /product="transposase"
                     /protein_id="WP_252550837.1"
                     /transl_table=11
                     /translation="MSSNVLAPADGRDAFSELSRFRTTFYGCLSARADMLIELTDALSC
                     ADGPTRSPVELSPLAEHQRGYGSLYGAP"
     gene            <20377..20721
                     /locus_tag="NFX46_RS18990"
                     /old_locus_tag="NFX46_18990"
                     /pseudo=""
     CDS             <20377..20721
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558177.1"
                     /locus_tag="NFX46_RS18990"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_18990"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="HDSQALGPLMKGIPPIRPRRGPRRRKPGKLHGDEGYDYRHLRRWL
                     SQRGIQHRIARKGVETSQRLGRHRWTIERTMAWLADCRRLHRRYERKAEHFLAFTNLAC
                     TLICYRRLTE"
     gene            20758..>20916
                     /locus_tag="NFX46_RS40715"
                     /pseudo=""
     CDS             20758..>20916
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020332.4"
                     /locus_tag="NFX46_RS40715"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MWALGDEEIRRVIEAARERAIERVLEWIADEVAVIRYDKDGIYRL
                     RPPGGLAA"
     gene            <20980..>21177
                     /locus_tag="NFX46_RS18995"
                     /old_locus_tag="NFX46_18995"
                     /pseudo=""
     CDS             20980..>21177
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014175410.1"
                     /locus_tag="NFX46_RS18995"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="NFX46_18995"
                     /product="nitroreductase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNSALKAAYFIIGIRAAGLAAGPMSGFDEDGVNREFFPSGDLSAL
                     LVVNIGRPERRSGERPRAPRL"
     gene            complement(21228..21593)
                     /locus_tag="NFX46_RS19000"
                     /old_locus_tag="NFX46_19000"
     CDS             complement(21228..21593)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018565210.1"
                     /locus_tag="NFX46_RS19000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_19000"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_252550839.1"
                     /transl_table=11
                     /translation="MRSSIEEAPDHCAIEFAMEMLGGRWKLAILKQLLVGTHRFGELRR
                     ALPGITQRMLTRQLRELEADGLVTRTVYREVPPRVEYALTDVGHSLESITEELGKWGRW
                     YREAVRPEGPSGPRPLA"
     misc_feature    complement(21417..21419)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 cgggtgaagc gggcggcgag gtaggttgcg gcgaagatgc ccagcgtctt gccggcgacc
       61 aggccgatca cgacaccgag gggttcggga ctggtgaata cggcgctcag ggccgggccg
      121 gagatgctca ccccggcggc gaagagcgcg aacagcggta ctgcgatgcc ggcggagagc
      181 gggtggacca ggtgcgcgac ccgggcggct ggtgagacct cttcgcccgg gtcgcgggtg
      241 gtgcgcagga gcaggcccat ggcgacgccg gcgacggtgg cgtggacgcc gccgttgtac
      301 atcagcgccc agatcgccac cccgaggggc acgtaccacc accagccgcg tacgcgcagc
      361 cgctggagca ggtagaagag caccaggccc gcgacggctc cggcgagcgc ccacaggttc
      421 aggtcggagg tgaagaacac cgcgatgatc aggatcgcgc ccaggtcgtc gaccacggcg
      481 agggtgagga ggaaggcacg cagcgctgat ggcaggtgcg tggagagcac cgcgagaacc
      541 gcgagggcga aggcgatgtc ggtggccatc gggaccgccc agcccgcact gctgccgccg
      601 cccgccgtgg tggtggccag gtagagggcg gcgggtacgg ccatgccgca cagcgcggcg
      661 atgacgggca gcgcggcggt ggccggggtg cgcagttcac cgacgacgag ctcgcgtttc
      721 agctcgatcc cggcgacgag gaagaacacg gccagcagcc cgtcggccgt ccagtgcccc
      781 accgacagat ccaggcccag ggcgggtatc ccgaagtgga agtcgcgtac ggacgcgtac
      841 gccgcgctcc acggactgtt cgcccagatc aaagcggcga gcgcggcggc gagaaggacg
      901 aggccgccga cggtctcggt gcgcagggcc cgggtgatcg cctgccgctc gggcagaggc
      961 agcaaaccga ggaaggggga gcgggtgccg gccatggcag tggtctccgg gtgcgtcgac
     1021 gaatgagggc acactgcccc caggacgccg accagacttc ccggcacacc gcgcgcctct
     1081 tcttgacgcg ttctttacac cgtatccacc ggtgggctgg ctgtctgccc cgcacgcctc
     1141 cgcaagatca catcggtgtc aggttgtgat cagccctggc aggggggcac accaccaggc
     1201 cgtggttgcg cgagcaccag tgggacggcc gcgtacagct cgggccgctc ggcaggcatc
     1261 gtgcagaggg cggcgcccgc gatcgtgaat gtccgggagg ccttccgcca ctggaacacc
     1321 ggtgccaacc cttccgacgg ctgtaacacg cgtgccgagg tcctgatctc cgaggccgtc
     1381 gccccccacg gtcggactca actgccgtcc gacgggcggg agctggtggt cgtactacga
     1441 ccaggtgtgg gtgacgtcag cctccggttt ggacatcgac cacatggtgc ccctcgccga
     1501 gagctgctga cagcggtgcg tcggcgtgga cggcgcggcg ccgcgaggcg tacgccaacg
     1561 accagggcgc ggccgccatc ctggtcgccg gcagcgcctg ctcgaaccgg tccaaggcgg
     1621 accaggatcc cgctcagtgg ctgccccctg gcggcggcgt gcactgccga tacgtcgccg
     1681 agtgggacgc aacgaagctc cgctggagtc tcacggcctg atgaagccga ggtggccgcc
     1741 ctgcgcgagg tgacggcggg gtgcacggac gagagcgtga cgtatgagcc ggtggtacag
     1801 ccggcctgcc caactcgccg tacgtgttcc gtcgtgatga agggtggtca tcgtgagccg
     1861 aggcttgatc gtcgcgggca accgcaggaa cgacttctgt gaaggaggca gtatccctgt
     1921 accgcgcggc gcgcggatcg cgaccaagat cgccgatctg gtggagcaga ccgcggggcg
     1981 tggctaccag tacatcgtcg ccacccgcga ccaccacatc gacccgggag gccacttctc
     2041 ccagaccccg gacctcaagg acagcttccc cgtgcacttc gtggccggag gcgagggcag
     2101 cgagttccac ccccacttcg cccccgccac ttcgcccccg ccgtcaccgg cggcaaagtc
     2161 gacgccgtct tctacaaagg cacccacagc gcctccaaga gcggcttcga aggagccgac
     2221 gaagaaggaa cccccctagc gcactggctg cgcgcccgcg gggtcgacga tgtcgacgtg
     2281 gtgggcatcg ccacggacca ctgcgtgcgt gccactgcgc tggacgccgt gaaggccggc
     2341 ttccgtgcac gggtacgcct ggactactcc gtcggagtcg ccccggacac gacagccgca
     2401 gccctggagg acttccacca ggcagggatc gccgtatccg gcgaggcacc cctagcgcag
     2461 tagcccccgt aggcgcggcg caggaccgga ccggatgtga gggcgaactg ctcagttgcc
     2521 ctcttgcacg cacgcgtgcc gcatgccgtc gtccggcgcc gcggctgtac gccgcagggc
     2581 tggccccgtg gccagatcac ggccgttgcc gctcggttct cagggctcca caccgcagcg
     2641 tcgcgcaatt gccttcaggc gttcgagttc ccggcgtgct gctgtcgggt gggcgagatc
     2701 aagggccatc ccggcgcggg ccgagatgta gaggatgtcc tggcgggtgg tggcgtcgag
     2761 gccgggggcg gtctgaaggc ggcggcccgt gaccctcagg tagagcgcga tgctatcgag
     2821 atcctcgcgc agctgcaccg gaagcacctg ccgcagttcg tccttggcgt agtcgcgcgc
     2881 ctgccggtcc gccgcgcagg gaccaggccg tacgggagcc cagggaaggc cagcttctcg
     2941 ggcgtcgtcg tacatctccg ccaccaaggc gcgtgcagac gcgggatcgc cctcggcggc
     3001 tgccgcgcgg gccgagtgca acgtggagcg cagtcgtgca cggacctgat catcctcgcc
     3061 ggtccgggcg ttcagatagc cggaccacac gtcaaacgcc ttgctcaact cggcatccag
     3121 cagcactttg tacacgtccg gcactccgcc gcccctccgt cgggcccgtc cgggcatgga
     3181 gggcagcgga caggatagga cgggcgctgg gcgctacgcc tgcgaattac ctggtgcagg
     3241 gtgcaggagc cacgcgtcaa ctgggatgcg tactgctggc acctggcgca acgtcgaatc
     3301 cggcccgggt gagcgtccgg caggcttggc gaacagtgtc tccgtagcgt tctcagtggt
     3361 catgctcgca gcagaggcag gtcaggctga ggctcttgcg aggcagcaga ggtgagggga
     3421 cagcggtgat gggagccggc ggtgagcagt gcgtgggtcc gtgcgttcgg acggtcgggt
     3481 cttcgagtcg tcctgctcga tcacgaagaa gtcgcccttg atgcggcgct tgagacccac
     3541 cagggcttcc gcgacctgct cccgggacag gtgatcctgg ccgagcgcct tgaggtacgt
     3601 gtcgtcgatc tgcgtaccca ccgcctggac caccaggctg atgtacctgg acgcctcctc
     3661 caggacccag cgacgtcgcc agctgccgaa ccagcgtccg caggaacaca tcacggtcca
     3721 gagtgcgagc gccagaagct ggaggcgcgg cacgggcagc gcagaagacc agcggccggg
     3781 gccccttctt ccgtacgtga agtacctgtg cccgaatcgg tcaggatgtg tgtggatagg
     3841 ctttggcggt gaccgctgat gccgtagaga agctgctcgc tgatgtgtgc gggacgttgg
     3901 cccgggccgg ctttgacgtg gcctcggccg gtgatgaggg cagccctggc ctgcgggtgc
     3961 ggagggatac ggactcggtg ctggtgggat gggtgcccgg cagcgagtta gatcctgcgg
     4021 gccgggagga tgccgtgttc gagggtattc gtgcagctct gcggtcggcg ctgctggcga
     4081 tcctcacgca ggccggtcat gccgtgcagg tggaccgcga gagcggtgag gtgcgggtca
     4141 ggctgcttgc gtgaccctgg gccacgggat cgacacccgc gttgccctca gggcgtggag
     4201 catttcgaac gccggcgggc ccggcgacgt agaacccgcg cgccggagtc ccgcgccctg
     4261 tcgactggtc cggcgacacc ttctgactgg gcagccgact cgccgcacgg ccctgccggg
     4321 agcgcgctgg gaggcgtgac cagcgcgccg atcgtcgtac accagccctc ccgtaccggt
     4381 ggccgaagtg tcaccgtgca ctcgcacggc cgcgacgaga tcctcggcac cactttcagc
     4441 gaccacgacc tggtggtgtt ccttcgagcg gcgggcgtcg accaacccga gggcgtgctg
     4501 gacgatccgc ggtgggtgga atggcgcgga ggccgcccac acgagtggag aacggcctga
     4561 gcggggccgc tcccaaaccg accgcgcaca gggtggtggc gtggtgtacg ggttcaccac
     4621 aaggggtggc gccgtttgag gcgggcggtg tcagtgggtc gtgagcatgc cctcgcgcag
     4681 ttgggccagg gtgcgtgaca gcagtcgcga gacgtgcatc tgggagacgc cgagccgttc
     4741 gccgatctgg gcctgggtca gttcttccac gaaccgccag tgcaggatct tgcgcgagcg
     4801 ctcatcgagg tcggcgatca tcggggcgag ggcgtggaag tcctccacca gttccagcgc
     4861 gccgtcttcg ttgccgatga agtcggccag ggcgctctcg ccgtcctcgc tgttgccgat
     4921 ggcggcgtcg agggaggagg agcggtagcc gttggaggca agacgcgcct cgatgacctc
     4981 ctcctcgtcc aggttcatca gctgggccag ctccgcgacg gtcggtgtgc gtcccaggcg
     5041 gctgctcagt tcctcggtgg cgcgggccag ttggacgcgg gcttcctgca ggcggcgcgg
     5101 cacgtgcacg gcccaggtgg tgtcacggaa gaaccgcttg atctctccca cgatgtaggg
     5161 gatggagaac gaggtgaact ccacctcgcg ggagagctcg aaccggtcga tggccttgat
     5221 caggccgatc acgccgacct ggacgatgtc ctccatctcc tcctggtcgc ggctgcggaa
     5281 acgagaggct gcgtagcgga ccagggagat gttcatctcg atcagcgtgt tgcgggcgta
     5341 ctggtactcc ggcgtgccct cttccagccg gtccagctgc tggaagaaca ggcgggtgag
     5401 ctcacgggcg tccttcggag cgaccctcga ggggtcggcc acctccggca gatcagcaca
     5461 cttcgcatcc gccgtcgtga ctgccgtatc cgtgaccatg tgtccctccc ctatcgaccc
     5521 tgccgacacc ggctcgtgtt gaatcggcac ggccgcatct accccttccc cccaccttca
     5581 tacctacctt ttccgcggga gcgtgccggt cggcccctca ctctctcagg ccccgaccac
     5641 cgatcgggca cgtcccctcg gcacccccca tcctgcccgg cttcttcaca ctcggccgaa
     5701 aggcgttacg gtcgcaggaa caacgtcacc gtcaccggga acccgcgggg gggcggacgg
     5761 tggtgctggc tcacgggttc ggctgtgatc agaacatgtg gcggctgacg gtgccggctc
     5821 tggtggagga ctaccgggtg gtgctgttcg actacgtggg ctcgggccgc gctgagccgt
     5881 ctgcgttctc ggagaaccgt tacgcctcgc tggacgggta cgcccgggac gtggtcgaag
     5941 tctgcgaagc gttcgacctg cgggacgcgg tgttcgtggg gcactcggtc agcgcgatga
     6001 tcggagtgct tgccgccgac atggctccgg aacgcatcgg cgcgctggtg atggtcgccc
     6061 cgtccccgcg ttacatcgac gacgacggct accggggcgg gttcagcgcc gaggacatcg
     6121 acgagctgct ggagtcactg gagtcgaact acctgggctg gtctgcggcg atggcaccgg
     6181 tgatcatggg gaacgcggag cggcccgagc tcggtgagga gttggcgaac agcttctgcg
     6241 ccaccgaccc cgacatggcg cgcgtcttcg cccggaccac gttcctgtcg gactccagag
     6301 acggtctcaa gcgtgtgagc gtgccgacgc tggtgctgga atgcacccag gacgtcatcg
     6361 ccccccgcga ggtcggcgcc ttcgtccacc aggcgatccc cggctcgacg ctggtgacgc
     6421 tggatgcgac cgggcactgc ccgcatctgt ccgcacccga ggccaccaac gaagcgatca
     6481 ccgccttcct ggcgggtctg cgttgatgtg ccctgccggg cagcagcccg acccgcacgg
     6541 cacaagcgag gagagaacag cgaatgcggc gttcgccgcg ctgctggagg acagtgcgga
     6601 ggagctgtac gagagcgcgc cgtgcgggta cctgtccacg ttgatggacg gcaccatcgc
     6661 gaagatcaac accacgctgc tggactggct cggcctggag cgggaggcgg tggtgggccg
     6721 gaagcgtttc accgacctgc tgactgtcgg cggcaagctc taccacgaga cgcacttcgc
     6781 ccccctgctg cgcatgcagg gcaagatcgg cggcatcgcc ctggagatca agcaggccgg
     6841 cggcgcacgg atgccggtgc tgatttcctc cgtggtcaag cacggcggta gcggtgagcc
     6901 gctactgatc cgcaccacca tcttcgacgc ccgagaccgc cgcacctacg agcaggaact
     6961 cctgcgagcc cgcaatgccg ccgaggaagc acgcaagcag gccgaggccg accgcgcccg
     7021 gctgcaggac gccctggccg tgctccagca gtcactgctg cccgccaccc tgccccacgt
     7081 gcccggagtc gaggcggccg tccactaccg caccgcctcc cccgaccagc tcggcggcga
     7141 cttctacgac ctcttccccc tcgacaacaa acgcttcgcc ttcttcctcg gcgacgtgtg
     7201 cggcaagggc ccccaagccg ccgccgtcac ctcactgacc cgctacaccc tgcgtgccgc
     7261 cgccttgcac gaccccgacc ccgaccccgt ctccgccctg accaccctca acacggcgct
     7321 ccacgggcgt tacaccggca gcggcgacgc gcgctactgc accgtcatct tcggcatcct
     7381 cgaacccgac ccggtcaccg ggcagatcac cgtccgactc gccgcgggcg gccacccccc
     7441 ggcgctcata ctccgggccg gcggcgcagt ggacttcctg cccaccccag gcggcttcct
     7501 cgtgggcgcc ctgcccgacg cgcgcttcgc caccgccacc accgtcctcg cccccggtga
     7561 caccctcctg ctctacaccg acggcctcac cgaagcccgc accggcaaag accgcaccac
     7621 cttgtacggg gacgaggccc tgcgagacgt cacagccggc cacgccggca accccccgca
     7681 agctctcatc caggccctga ccggcctgct ggacgacttc ggcgacggtc tcgacgacga
     7741 caccgccctg ctcgccctcg gcatccccac tcccactcct gacccaagga ccgaaaacac
     7801 cgcatgagtc cgctgaagat caccacccga gacgccatga ccggtcccgt tctggagatc
     7861 atcggcgaac tcgactacac cagcgccagc gaactgccgc acctgctcac cacgatccct
     7921 cttcagccag gacagcgcct cgtcctggac ttggccggca tggaattctg cgactccagc
     7981 ggcatcagcg ccctgatcgc cgcccgtaac cgcgcccata ccgcccaggc cgatatcgcc
     8041 ctcgccgcag ttcttgccca taccctgcgc gtgctgcgca tcgtcggcct cgaccagatc
     8101 ttctccctcc accccgacag cgacgccgcc acccagccgt gacccacaca cgctcatcgc
     8161 acggcgctgg gcagccgctt ctacaacctc tgaccaccct cgccccaccg ggacaggccg
     8221 ccactcatgg cgcccgaata tccgcggcct ctgctgccgt actcatctcc gcttactgat
     8281 cgccacccgg aagggctgcc ggtgggggac acggtcttcg ggccgtgccc cgtccgaccg
     8341 ggcgcccctg gctgacgtct gatccgcggc cgtcaacccg taggcgaggc cctgtgattc
     8401 atcgagcgcc ctgcggatgc cgccctcgaa cagggcgcag ggtgacctgg cagccctggg
     8461 cggggtaggg ctccgtgctg gcgcggtggc cgattccctc gtcctgtcgc gtcgccggca
     8521 ggagctgccc acggcggatg agtgtgtgta ccagcacggt gacctggagg aaggccagtt
     8581 gaccgccgat gcaggcgtgc gtgccagtac cgaaaggcag ccaggcgccg cgaggaggcc
     8641 ggttccccag gaaccgttcg ggacggaact cctccggatc ggggtacagc tcggggtttc
     8701 gatgcagatc ccataggctc gctacggcga atgtcccggc cggcacgtgg tatccgccga
     8761 tgtcgcatgg ctcgcgcagc agccagggga tggctgtgac cggcggtcgc agacgcagtg
     8821 cttcgcggat gaccgcgtct gtatagggag cgctgtcatc ctgtccggat gcctcctcga
     8881 ccagccgttg ccacacgtgc ggtgtgcgcg tggcgcgctc gatgacccag gccgctacca
     8941 gggcgggagc ctgggcagcc aacaggtaga aggcgatctg gtcgcacagc accgcgtcgg
     9001 tcagtagttc gctgtcggaa gccagcaata tgcccaggac atcgttgtga atcgtgccag
     9061 tgcggcgtcg ccgggcaact tccccgcgca ccagatgaag gcaggcgttc caagccctgt
     9121 gtcccgtagg ccaccagggc agcatgccca ctgcgtaggc catcaccgca gggcggacgg
     9181 tggtctggcg gagccgggcg atggccttga cccaggtgtg cagaaggcga ggatcgtcga
     9241 cactgaggca cgctctgacg ttggcttcgg cgacggctat gtccagcaag gggagtaggc
     9301 ggaaaggcct tcccacaggg caggcattcg ccatgcgctg tgctgcgacg gcgatggcag
     9361 cccggttgcc ggacagggcg tcaccgcgca gggtggggat catcagccgg cttaccgcat
     9421 ggtgctgtgc gccgctcagc tggttcagca tcgccgtgga gcccatcacg cgccccagaa
     9481 gacggccagt cgtgttgtgc tccactccgg agctgtgcag gacttgctcg atcagacgcg
     9541 gatcacgcag ccatacggct ctgacgcccg gcgcccagtc ggggacgatc gtgccgtgtc
     9601 gggcgaagtg gcgctccatg tagtgcgggc ccgagaggaa acgacccatc atgatcggca
     9661 tgacggcggg ggcgggtagt ggcttgagtg gcaacttctc ggccatttgg aagtgttccc
     9721 ggtcaatagg aggtcaggta tgagggcgta ggttcctggc acggtgttgc tgggcttgag
     9781 cgcagcgccg aagctgtgcg tttcgccgtc tgaagatgcc gagtctcaaa gcgggtcgcg
     9841 gcagtcgatg caggcctgag cgcgtcttga agtggggtgt tgtcggggat gtgagcatgg
     9901 cgttgaggtg catgctgcgc ccaggcggcg gacagggcgg catcagctgg atgagcgcat
     9961 gctcgggttg ggagcgacac cgccccctgg ggcaccgcga tcagggttgt tgtggctcat
    10021 gagacaccac tgccgtgagg ggggcgccgt ggcggcgctg tcggcgggtg tattcggaga
    10081 tggcctgcca cagatggcgc cggtcggtct cgggccagta gtcggcggtg aagtacagct
    10141 cggcgtaggc ggtatgccag ggcaggaagt tggagatgcg ctgttcattg ccggtgcgcc
    10201 acagcagatc gacatccggc atgtccggtt ggggaaggtg ctgtgcgacg tccgtttcac
    10261 tgatcaggtc gggatcaagc tgtccgcttc gtacccggcg ggcgagagcg gtagcggtgc
    10321 gggtgatctc gtcccggccg ccgtaattga tgcaagtggt cagtgtcagg ccggaacggt
    10381 cacgtgtgct gctctcacgc atcctcatga ggtcgatcac gtcttgaggc agcctgtccg
    10441 ggcggccgtg ccagcgcacc cggacgtcaa gatcctcgag agggtattcg cgcagctctt
    10501 ggtgcaggag ggcgaggatg gtgccgatct cttcatcgtc gcgcttccag ttctcggtgg
    10561 agaaggcgta gagggtcagg tgccgcaggc cgatctccag agcaccgtag accatctcgt
    10621 aggcggcgga acggccggtc cggtggcctt cgtgccgggg caggccccgt tgctgtgccc
    10681 accggccgtt gccgtccatg atcacggcga cgtgggtggg catctggtcg actggaatct
    10741 gtggtggtcg ctcaccgctg gggtgtggtg gcgggctgcg aaaggccggg cgctgcgcgc
    10801 gcggacgctg tgtgagcacc gtgtcgtgcc gggggcggcg tggtggtggc acggtcacct
    10861 cggtcaggct ccaggcgaga gcggcgcgcg cccgagccgg ggcgaggagg cgggcggtgg
    10921 tgacgaagga gggcctgggc ggggcatgaa agagggtggg accggcggcg ctcacggcat
    10981 cgagctgtgc gcgcagcagg tcggccatgg tgtcgaggac ggttgcgagg ccggggtgca
    11041 ttcctcgggt gagggcaggc tgggtcaccc atcggcgggc aagcccggtc aggtcagtga
    11101 tcaggccggc ggtggaagga ctccagcgcc gctgctccag gtcgtccgca gatcccggga
    11161 actgatcgag gctctggccg ggcaggagaa ggtccccctg ggcgaggtcg gcggacaggt
    11221 cggtgaggat gtcggtgagc cggacgccgt cgaggaactg ctcgtagacg tcctgcctgt
    11281 ccagtcggag tgtcaccgcg acgccggccc tgtcgaagag gtcgcggacc tggtcgaacc
    11341 agggcagcag gttgccgcgg ccccaggcgc gccagctgct ccagtcggtg aactgccttc
    11401 cgtgggcgtc gtgctggacc agtgtcatgg cgttgtgcag ctgtgagatg tccaggcgcc
    11461 agcgccaggc ggtgtccacc agggccaggc ggatcgggtc tgtgcttgtc ccggttgcca
    11521 gttcatggtc cagggcgctg atccattccc cgacccgtgc ggctcgttcc tcggattcgg
    11581 ccgtgcggtc gtcggcaagg tcgtcgaggg cgttggccgc cgtccatagc gcccagcagg
    11641 ccgggcggag caccgcaggc accagttgga tcagcgcgta ttccgccggg tcctgctgct
    11701 ttgttcgggc cctgcagagc aggtacgccg cctgaagcgc cgggtcgtca ccgaccaccc
    11761 ccgctagcaa cctcgtcgag cggtgaccag ttcgcagggt ggcaggccgc tgcccgcctg
    11821 aagtggtgga gtgcacactg atcacaacga gagcacagca tcgaggttgt gctggtgatc
    11881 aagggctgtt ggcgcgtcag ttttctggca gcgtcagccg cgcggcaggt cccggctccg
    11941 ccgcgtcgag aaccggggtg gaaggcaggg cgctgcgggt gcgccactgg aaggtcagca
    12001 ggcacaaaag cgctgccgca gcgaaccagg tcagttcgat gagcaggtac ccggtagcgg
    12061 aggtgctgga gaaggctgct gcggtggctg cctgcatggc gccgtaggaa ggcaggtagt
    12121 gcgtgatagc gctgtccgcg ctggaactgg agatggggtt ctgtagcgcg atgtcgacga
    12181 cactggtcat cacgatggcg aacatccctt ccacttcctt gcgcagcaac gcgccgaagc
    12241 cgactccgag tacgccgtag gtcagcccgg cgctgaagag ggccgcggcg agcagggccg
    12301 gctgacgtgg agcccaggcc aggtacatga cggctgtcgc gtaggcggcc accagggcgg
    12361 acgcgagagc gaggccggcc aacttcgccg cgatcagatg aggtcgtgga tagccggcca
    12421 tcacaaggcg ccggtcgaac tggctgccgt tgaacgtcgc ggcgaacatc aaaaacccgg
    12481 tgatcaaggt gaccgcgttc agcgcaccgc tgaccgcggt gagctcgttg ccgtgaggcg
    12541 tcaggagctc ccccgtggcc tgcagccgca cccgcaccgg cccgtccggc atcgacacat
    12601 acgccagaag cgtccacacg ggaaggaaga ccgcgatgag caccgctgcg aaccggttgc
    12661 gggcgtgctc ggcgaccgcg taccgcgtgg ccgtgacgag cagcatcacc tgctccctca
    12721 tgccgcttcc ctcccttgcg cctggagacg accgccgtcc aggcgccaca actcgtccaa
    12781 gcgctgggtg tcgtaggcga gatgagagac caccagaact gaacgccccc gctcgcgcaa
    12841 ccgggatgca agctcccaga accgcaggta ggtgtcccag tcgaagccct gatagggctc
    12901 atccaacagc agcacctgcg ggtcgtgcat caacgccagc gtcacgttca gcttctgccg
    12961 cgtccctccg ctgagcacac cggcccgctc gtccaggtag tcggagaaac cgagcacatc
    13021 catgacctcc ctcgcatagc caaggctgtc gagacggaac gccgcacgga agaacgccaa
    13081 atgctgacgc accgtcagtg catcgttcac cactacctgt tgcgggcagt acccgaaccg
    13141 gccaccgtga cgaacactgc cccgcgaggg gcgcaactcc ccagcgagaa tcctcagcag
    13201 ggtggacttg cccgcaccgt tctcccccac caccccgatc aacgatcccg caggcagggt
    13261 gaagtcgaca ccccgcagca ccagcctctt gccatagtga tggtgtacat ccacaacctc
    13321 cacgccgcga cactcccacg ctgcttgcct ggacgaccgc aggctttaac gaacgcgacc
    13381 ggccacgggc acgcagccac acggtgatcc cagcgggtga gcgtccccac ggaaaatggc
    13441 ctgcaatgcc ccacagacca gccgcttcgg ggctgccagg gcggcgcgct cagccacagc
    13501 cgcccggcgg gacagctccc gaagtcgccg cgccgcccgg cgggatgacg agggccgcaa
    13561 cgagctgctc atcagcggcg aggtgatcga ggagcgccgc ggcaaggtgc tgaggcgccg
    13621 cccagtgcca tgtccggccc agcctgacag gcccataccg ccattggggc taattcaccc
    13681 ggataggcgg cacttctgga atccggccga gcatcggact ggaaacatat ccccaagccc
    13741 gacgccccct tcttctgcag ccgcgaacag ggctgttgga ccggtcggcg tctttcgggc
    13801 ggcggacaga tctcagcgga caaggacatt gatgtgacgc gtaccgtcat ggccgaaccg
    13861 gcccctcgct cggaccgtat gagtcgcaag tggttcgact atgcggccgc gcatccgtcg
    13921 acatcggtgg ccatcggcgt ggtggccctc tgcaccggcg acctgccgac ccgcgaggag
    13981 gtcgctctcc tggtctctct ggccgttgac gcctacccgg agttgggccg gcaccccgta
    14041 cccaggccgg ccgggagcgc gggcgcaccg ggaacgccgt tccgactcga ccggcagatc
    14101 ttcgaggtcg aggcggcgag cggttccgga cagaccggcc tgagggcggt cctcgaacag
    14161 ctcacggcgg agccgctacc cgaggcactc tggggtgtct ggctcgtgca cggctatgcg
    14221 accggtgagt tcgcggtcgt cctgcgcggc catcacgcgc tgttcgacgg tctgctcctg
    14281 gcggacatca tcgcatgcgc actgggcgcg gaacctcgtc ccaccagggc cgttgccggt
    14341 ccgccgccgc ggcgcggcgc ctacgcggca gcgctgcggg aggctcgtgc cctgttccgg
    14401 gaccggggcc gggcagcgca acctgttccg ccctccgtca agctcacggg aagggtccag
    14461 tacatgtggg agggcgtgcc cgtggaacgg atgcgcgaag ccgcctccgc acaccgggcg
    14521 acgaccaacg acgtgtatct ggccgccctg gcaggggcat tgcgggcctg ggcgcccgac
    14581 ccccagtggc tggccggtgg ccggccggtc cgggtacagg tgcccatcgg gtatccccac
    14641 gaggctggtc gcctcggggt ccgcgcgact gcggcctggg tgcggctgcc ttgcgaagtc
    14701 gacgatccgg ccgagcggat cgccctggtc aaggtgcaga ccgaccgcct gcgggcctcc
    14761 ctgcgcaacc cgcacaccgg cgcgctgacg cggctggtca gcaggttcct cggccggttc
    14821 gatctggacc tgcagtacca ccccggctgg atgtccatgc tggtcagcca cgtgcccgga
    14881 cctgccgcca cgccggcgat cgcaggccgg acggtcaccg ccggtgtccc gctgatgttc
    14941 ctgcccgcga gccagtactt ggccacggcc atgtgcgact tcgccggcgt gacacagctg
    15001 tgcgtggtcg cggaccgagc ggtgcccgac gtcggcgagc tggcacaaca gtgggtccac
    15061 caggtcggcc tcctcggcgg ccacgaatga cacaccaggg gaccggcgtc gaccgggcga
    15121 ccgtcgaccg ggcgcaagcg ccgccccctc ggctttcgcg gtcggcccag caccggccat
    15181 ggaccaccat cctgctctgg gtcctgttct gcgggctcag tgggctgctc gccgcggacg
    15241 tgtcggacag gcttgtcggc ggaggcttca ccgcgtccgg tgccgagtcc gagctcgcgc
    15301 aggcgcggac ccaggagcgg ttcggcgtcg ccgacccgga tgtcctgctg ctcttccgtg
    15361 ctcaggccgg ggggccgacg ggacccgccc tgaggcaaca ggtgaagagt gtcgtcaccg
    15421 ccccggccgt gacccggctt gccgagccgc taccgacttc cccggacgga gcgccgtcgc
    15481 tggacgccag tgccaccacc gccctcgtcc cgctcgtcct ggacggcgac accgaggagg
    15541 ccaagcgccg gaccctggag gaactgcgca gcgcggttcg gccgccgtcg gcggtcacac
    15601 tctcctacgg tggaccgatc gccttcctcg acgaggccag ctcccgttcc caggccgacc
    15661 tggtgcgcgc cgaactgctc gccgcgcccc tgttgttcgt cctgctgctg ctgatctttc
    15721 ggggcctggc cgcggctatg ctgccgctcc tgaccggggc agcggcagtc gtcatcggca
    15781 tggccgtgct gcgcgtggcc accgagttca ccgaagtgtc ggccttcgcc gtcaatctgg
    15841 tcagcatgct cggcctcggg ctggcagtcg actacgccct gctcatcctg acgcgctacc
    15901 gccgggagcg ccggcgggga ctcaccgccg agcaggcacg cgccatcagc ctgcgcacgg
    15961 cagggcgtac cgtgctcgtc acctcggccg tggtcacggc ggccttggcc gtgctggcac
    16021 tgttccccct ggccttcatg cggtcgctgg cgatcggcgg gtgtgctgtg gtcgtcgcgg
    16081 acgtggccgc cgccctgaca ctccttccgg cactgatggc cgtcctcggc ccacgtgtcg
    16141 acgcaggaca cggaccggtc aggtggtccc gccggagcgg gcggacgaaa cgcccggaag
    16201 gggagcggtg gcacacgctg gcggcactcg tcgcccgccg cccggcactg tggctgatcg
    16261 cctgcaccgt cgttctgctc gccatggcag cccccgcgct gcgcaccacg ttcggaggta
    16321 tcggtgaggg gacgctcccg tcctcctccg cctcccgacg cgtcgccgag gagatccgcg
    16381 aaacctttcc cgccctgcag ccagccagga tccaagccgt cgtggacctg gccgcgccgc
    16441 ccgactccac cgcaggcaag gaggcgctgc gtacatggct cggtcgggtg gccgcccttc
    16501 cgtccacccc ccgggccgag gtcacagcgg tgcgcggcaa cgcgctgctg gtgtccgtcg
    16561 gcgccaccgg cgagcccgac gcggaccggc gaaccgttcg agccctcagg gccttggcac
    16621 cgccgcaagg cggcagtgtc ctcgtcggcg gcagcgcggc cacggacacc gacatgaccg
    16681 acgcgctcag cgccaggctg cccctcgtgg tgggtctcgt catggccgtc acctcgctcc
    16741 tgctcctgct ggtgttccgg tccgtactgg taccggtcaa agccatcgtg acctcggcgc
    16801 tgtcgacctt cgcctgcctg ggggtgatga cctgggtgtt ccaggacggc catctggcgt
    16861 ccctgctcgg gttctcggcg ctcggctacg tcgagaccac ccagcccgtc gtggtcctgg
    16921 tggtgctgta cgcgctgtcg gtcgactacg agctgttcct gctcgcgcgc gtacgcgagg
    16981 agtaccggtc caccggggac aaccggcatg ccgtcatcgc ggggctgcgg gacaccggta
    17041 cggtgatcac gggcgcggcc gccctactgc tcgtggtcat cggtgcactc accaccagca
    17101 gtgtcatcgc catcaaggaa gtcggcgtcg gcttgttcgc cggtgtgctg atcgacgcaa
    17161 cccttgtaag gctgttcctc gtcccggcgg ccctgctggt agcgggccgc gccaactggt
    17221 ggccggggcg ctcgccatgc gtcacaggcc cgtcaggcat cgcgaagctg cccgctcccg
    17281 cggcggatcc ccggatgaat accgacgtac agcccccgca gcccgtgccc gatggcgccg
    17341 gcacccccgg gtcgcccggc acccatccat cccgtctcga ggagaaacgc tgaccgtcat
    17401 ggaatttcgg cagttgggcc gcagcggcct gaaaatcagt gcgatcgctt acggaaactg
    17461 ggtcacgcac ggatcccaga tcgacgagca gggtgcgcgc gcatgtgtcc acgccgcgct
    17521 cgacgaaggc atcaccacct tcgataccgc ggacgcctac gcggccacga aggcggagga
    17581 ggtcctgggc cgcgcactga aggggcaacg gcgcgaaggc gtggagatcc tcaccaaggt
    17641 ctacttcccc acgggccccg gtgccaatga ccgtggcctg tcgcgcaagc acatcctcga
    17701 gtcgatcaac ggctccctca aacgcctggg ctgcgactac gtcgacctct accaggcgca
    17761 ccggttcgat ccgacaacac cgctggagga aaccctgcgg gcattcgacg acgtcgtccg
    17821 tcagggcaag gccctctacg tcggggtctc cgagtggacc gcggaccaga tccgggcggc
    17881 cgtgaagacc gcggccgcga tgggcctgga ccggatcgtg tccaaccagc cgcagtactc
    17941 gctgctccaa cgggcgatcg aagaggagat cctgcccctt tgcgccgagg tgggaatcgg
    18001 tcagatcgcc tggtccccgc tggcccaggg cgtgctcacg ggcaaatacc tgcccgggtc
    18061 gccgccgccg caggggtctc gggccacgga tcccgccggc cgcccccgga tcgcgcacct
    18121 cctgcgggac gaagtcctgg acacggtgca aaagctcggc cccgtcgctc gcgaagccgg
    18181 cctgaccatg tcccaactag ccctcgcgtg ggtcctgcag aatcccggcg tctcgtccgc
    18241 catcatcggt gcgtcccgcc ccgaccagat ccggcagaat gcagcggccg ccgaggtgac
    18301 actcgacgcc gacctcatga aaacggtcga cgacctcctc ggtggtgtcg tgaaccgtgc
    18361 cgtaccggtc tgagcgcccc ggcgtgacac cggctcacga cccgccgtgt accggggcgc
    18421 tccccgaaag ggtcaggcct gctccggtgc ttccgttcga gtggagcctc ccggctcggc
    18481 gtgccacggc cggcccctcg tcgttgagcg gggtgtacac cggttcactg gacaccggtt
    18541 ccacccccga aacccgtccg gattcccgag tcgaagcgag tggtcgatgg cgaacaccta
    18601 cgaactgacg gtccaccacc tggtgagcga cttcggcatc gagccgacca cgatcagccc
    18661 ccaggccaca ccggcggaac tcgacctgga ctcactgtcg ttggccgagc tcgccgtgat
    18721 cctccaggag cagaccggga tccgactgga ggaggtcaac gccggcacca gcctggagga
    18781 aatcgcccgg cagatcgacg ccgcccgggc cgacgcggcc acagcagccc gatgacctca
    18841 caggcggtgg cggtcaccgg ggtggggttg gtgaccccgg ccggaatcgg cgcccaggcc
    18901 acctgggagg ggatgcaggg cgcaacttcc tacgcggcgc ccgacgccct gctggccggc
    18961 ctacctgtcg acttctcctg cgccgtcccc gactgggagc ccgaccgcgt cctcggccgc
    19021 atgctcagcc gacgcctcga ttccccggcc cagatggcgg tgctggccgc acgcgaggcg
    19081 ctggcggacg caggtctgtc gtcctccggt tgggatcccc accgggtcgg cgtgatcatc
    19141 ggtgccggga cagccagctt ccagcatctc cacgacgtgt acagcaagat tctcaccggt
    19201 cggcacgaac tcgtctcgcc catggcactg ccccgttcgc tgcccagcgc accggtgtgc
    19261 gcggttgcac tggacctggg cgcgcagggc atgagcttcg ccccgtccgc cgcctgcgcg
    19321 tcgggggctg tcgccatcgg cctggcacta cagttgcttc gcgccggcag cctggacgtg
    19381 gtcctggccg gcggggcgga gagcgggcgc tctgccatca gcgccgcctg cttctcccag
    19441 atgggcgcgc tgtccacccg ccaccgtgac ccctccggag cctcccggcc gttcgacgcc
    19501 gaccgcgacg ggttcgtcct gggagagggg gcaggagtgc tcgtcctgga gagcctcaag
    19561 cacgccaggg cccgccaggc gcgcgtctac tcctacctcg ccggatacgg ctcctccacc
    19621 gacgcccatc atgtgaccgc ccctcacccc gagggacgcg gcctcaggca ggccctgcac
    19681 gaagccctcg tcgacgcgtc ctggacggcc gcagacgtgg accacatcaa cgcacacggc
    19741 acggctacac gtctcaacga ccacatcgaa gcgcgggtcc tgtccgacgt cttcccccgg
    19801 gtcccaccgg tgacggcacc caagggagca ctcggacacg ccatgggggc cagtggagcc
    19861 atcgaggcgg cgctcaccgt cctgaccctg cgccatcaga ccatcccgcc caccgccaac
    19921 ctggaccggc ccgacctggc cctcgccagc ctcgacatcg tcaccaagag tccccgccct
    19981 gcgaggctgc acaaggccat cagcacctcg gtggcattcg gcgggcacaa cgccgcccta
    20041 gcgttccaca gcgccaccac ggaaagcgac atcgagatgc ggatctgaac gagatcggcg
    20101 tgcgctggtg gtcgacgcag tgtccagcaa tgtgctggcg ccagccgacg gacgggatgc
    20161 gttctcggaa ctgtcacgct ttcggaccac cttttacggg tgcctgtctg cccgggcgga
    20221 tatgctcatc gagctgaccg acgcgttgtc gtgtgcggat ggcccgaccc ggtcaccggt
    20281 cgagctgtcc ccgctcgccg agcaccagcg cggctatggc tcgttgtacg gcgcgccttg
    20341 aatcacggcc ggatcggcgc cgacgcgctg cgggcccacg acagccaggc cctgggtccg
    20401 ctcatgaagg gcataccccc gatccggccc cgtcgcggcc ctcgccggcg caagcccggc
    20461 aagctccacg gcgacgaggg ctacgactac cgccacctgc ggcgatggct gtcgcaacga
    20521 ggcatccagc accgcattgc ccgcaaaggc gtcgagacct cacagcggct gggccgacac
    20581 cgctggacga tcgaacggac catggcctgg cttgccgact gccgccgact ccaccggcgc
    20641 tacgaacgca aggcagagca cttcctcgcc ttcaccaacc tcgcatgcac cctcatctgt
    20701 tatcgccgac tcaccgaatg agatgactcg tcaaggccgc agccgacgat caacctgctg
    20761 tgggcgctgg gggatgagga gatccggcgg gtgatcgagg ccgcgcgcga gcgggcgatc
    20821 gagcgggtgc tggagtggat cgcggacgag gtggcggtca tccggtacga caaggacggc
    20881 atctaccgat tgcggccgcc cggcggtctg gccgccgccc gcttccgcct gcggatctct
    20941 acgcagagaa tcgcgcccta cgggaacggg tccgcgctgc tgaacagcgc cctcaaggcc
    21001 gcctatttca tcatcggaat acgggctgcg ggcttggccg ccggacccat gagcggcttt
    21061 gacgaggacg gcgtcaaccg ggagttcttc ccgtccggcg acctctcggc actgctcgtg
    21121 gtgaacatcg gccggcccga gcggcggtcc ggcgagcggc cacgcgcgcc ccgcctggcg
    21181 aggtgtgcac gacactgtga cgccgcaccg tccggccttc ggccaggtca cgcgagtggg
    21241 cgagggccag acgggccctc ggggcgtacc gcctcgcggt accagcggcc ccacttgccc
    21301 aactcctcgg tgatggactc caggctgtgc ccgacatcag tgagcgcgta ctcaacccgc
    21361 ggcggcacct cgcggtacac ggtccgcgtc accaggccgt cggcttccag ctcccgtaac
    21421 tggcgggtca gcatgcgctg ggtgatgccc ggcaacgcgc gcctgagttc accgaatcga
    21481 tgggttccca cgagcagctg cttgagaatg gccaacttcc aacgaccccc gagcatctcc
    21541 atggcgaact cgatcgcgca gtgatccggg gcctcttcga tgctggaacg cacgactgac
    21601 ctccattggt atacagcctg gcactaaggg acaccaaaga ccgtacttgt gacccgcgtt
    21661 ggtacgtccc gaaactgaaa ccatgtcgaa caaggaggca cccgcaccgg tgcgagcaat
    21721 cgaagagacc gagcacaggg agcctccggc cgccccgc
//
