LOCUS       NZ_CP099468            28452 bp    DNA     linear   CON 04-JUL-2024
DEFINITION  Streptomyces phaeoluteigriseus strain Qhu-M197 chromosome, complete
            genome.
ACCESSION   NZ_CP099468
VERSION     NZ_CP099468.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces phaeoluteigriseus
  ORGANISM  Streptomyces phaeoluteigriseus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
REFERENCE   1  (bases 1 to 9026270)
  AUTHORS   Zhang,B., Xiang,X. and Fan,J.
  TITLE     Complete genome sequence of soil microorganisms Streptomyces sp.
            Qhu-M197 isolated from Alpine meadows habitats on the Tibetan
            Plateau
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9026270)
  AUTHORS   Zhang,B., Xiang,X. and Fan,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-JUN-2022) Faculty of Eco-Environmental Engineering,
            qinghaiuniversity, No. 251 Ningda Road, Chengbei District, Xining
            City, Qinghai Province 810000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: Hifiasm v. v0.14; Circlator v. v1.5.5; Pilon v.
            v1.22
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 68.51291x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023923245.1-RS_2024_07_04
            Annotation Date                   :: 07/04/2024 06:06:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,100
            CDSs (total)                      :: 8,006
            Genes (coding)                    :: 7,707
            CDSs (with protein)               :: 7,707
            Genes (RNA)                       :: 94
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 299
            CDSs (without protein)            :: 299
            Pseudo Genes (ambiguous residues) :: 0 of 299
            Pseudo Genes (frameshifted)       :: 130 of 299
            Pseudo Genes (incomplete)         :: 241 of 299
            Pseudo Genes (internal stop)      :: 34 of 299
            Pseudo Genes (multiple problems)  :: 90 of 299
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:40:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3851515
            Orig. end                         :: 3879967
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP099468.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..28452
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="16"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..28452
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..28452
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:18452]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..18452
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(712..2304)
                     /locus_tag="NFX46_RS17135"
                     /old_locus_tag="NFX46_17135"
     CDS             complement(712..2304)
                     /EC_number="3.1.1.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007268023.1"
                     /locus_tag="NFX46_RS17135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_17135"
                     /product="carboxylesterase/lipase family protein"
                     /protein_id="WP_252550277.1"
                     /transl_table=11
                     /translation="MSGPLARLSTTCRRRWLSPRRLVVPAVALLLSATAMTSAPAAAAD
                     GPIVTTRYGQVQGKVGETATSYLGIPYAAPPTGPLRWRPPVPPARWSGIRDARTPGNPC
                     VQRVQSSPWGDLAGPGTPSEDCLYLNVYTPAQRSLQKRPVMVWIHGGGFTVGSGTFYDG
                     GNLAAKGDVVVVNLNYRLGAFGYLAHPSLAKESAQGISGNYGLLDQQAALRWVRDNIVA
                     FGGDPDNVTIFGESAGGGSVCQNLVSPRTTGLFDRAIAQSGCGFPLPTQESQQNNGQAW
                     ADSLGCADAACLRTRTAQELLTASAAPTARWTPNVDGKVLPLQVPDALDIGRFHRVPVL
                     QGTTADEGRLTVATTYDLAGRQLTAAGYPVAVRALHGERADEILARYPLSDYGTPAEAL
                     GAVLTDSQFACLQSRTASLMAEHTRSYQYEFADRHAMDYLNMPISFPIGAPHGSEIRYV
                     FGSVSGTPAQNALSDSMLGYWTNFARTGVPYAAKAPRWDLFPKVQVLAPEAITSVLTFP
                     TDHKCDLWSPATA"
     gene            complement(3480..4448)
                     /locus_tag="NFX46_RS17140"
                     /old_locus_tag="NFX46_17140"
     CDS             complement(3480..4448)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1015: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004933729.1"
                     /locus_tag="NFX46_RS17140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_17140"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_252550279.1"
                     /transl_table=11
                     /translation="MSSVLDTAYIPPRDREEVIRHAVWESVVAVDIDHRPAAEDISVRT
                     GLGTVGPLRICSARATAVTIRRTERLARKDEEPAVFLGLQVTGSSLVAQNGRECVLRPG
                     EFAVYESIAPYTLLFDEGVDHHFLRFPRAALALPDRLLRDTTTVTLGSDNPVARLAFTY
                     FSQLAVSDELHQGVHADAVVEPSVELLRAVLTSQHGRSSLAKGPLEATLGLRVTQYIRE
                     HLADPDLSAARIAAAQGISVRHLYAVLSRSGISLGDWIRTRRLAECRRELAGPNGRLRT
                     VAAIGRSWGFADATHFSKVFKQAYGISPRAWRDENHPRSSA"
     misc_feature    4531..4545
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.5"
                     /tool="antismash"
     gene            complement(5315..5752)
                     /locus_tag="NFX46_RS17150"
                     /old_locus_tag="NFX46_17150"
     CDS             complement(5315..5752)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NFX46_RS17150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NFX46_17150"
                     /product="hypothetical protein"
                     /protein_id="WP_252550281.1"
                     /transl_table=11
                     /translation="MPHIDPTRMVELALGHDASHNDVSAWQHIGVCERCEEELRLTTWV
                     ITAARSVQEPDLLACPPERVWQHIAQELAEPCEATPPPPAASLRGPPAVSADSRHRRSP
                     GTGSRRTPLACGLLASLLIVWWRRRKRSFRPSESASDHPPV"
     gene            complement(5911..6522)
                     /locus_tag="NFX46_RS17155"
                     /old_locus_tag="NFX46_17155"
     CDS             complement(5911..6522)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324498.1"
                     /locus_tag="NFX46_RS17155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_17155"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_252550283.1"
                     /transl_table=11
                     /translation="MTTNVRHTGVRTPATQEARYEEELARGLLAADENAFAAVYRRWGS
                     LVHTMATRSLGDTFEAEDVTQQVFLGAWRGRNGYRPEKGPLGGWLVGITRRKIVDALAA
                     RTRRLTLIETVTHDADGRRHEVGATTDGVLDRVLLVDALSRLPHGQREVLCLGFYQDLT
                     QAQIAERTGMPLGTVKSHTRRGLHRLREAVEQGRAEENTA"
     gene            6682..7680
                     /locus_tag="NFX46_RS17160"
                     /old_locus_tag="NFX46_17160"
     CDS             6682..7680
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005320554.1"
                     /locus_tag="NFX46_RS17160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_17160"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_252550285.1"
                     /transl_table=11
                     /translation="MDLDEGDGGEAEVRRGGGMSTGEVARRLGVAPTTVRSWDRRYGLG
                     PAAHTGGRHRRWTAADLARLERMCALTATGLPPAEAARLALDETGSTTPPREADSSPVP
                     QSVARSRSRAGTGLRLDDVRQECKGVARAALRLDATALDELLKDAIGQHGLIAAWTEVI
                     MPTLQAVGRKWESSGERYVEVEHFLSWHVSGALRRHSPPVPTDRPGATTVLACVPAENH
                     TLPLEVLAAALTERDLPIRMFGGSLPVESLVAAVRRTGPAAVCLWAQSRTTASRPLAQH
                     IAAIEWGVRGARRKPVVLTLGPGWAGQTTPGLPHPPGLAEAVAAVESAMRR"
     gene            7906..9153
                     /locus_tag="NFX46_RS17165"
                     /old_locus_tag="NFX46_17165"
     CDS             7906..9153
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152490.1"
                     /locus_tag="NFX46_RS17165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_17165"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_252550287.1"
                     /sec_met_domain="DAO (E-value: 2.1e-09, bitscore: 36.3,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSQQRGTPDTVVVGAGLAGLACALDLCRAGRSVTLLEASDGVGG
                     RMRTDRRDGFLLDRGFQVFNTSYPQVKRRLNLRNLQLRPFTPGIIARTSTGDVRLADPT
                     RQPRAAKSLLPGRVLSAGDLAAMGALTARDALLPAALLKHRPDRSTAAALSRAGLSERT
                     VSEILRPFLSGVFLEDRLETSARFFHLVWRSMVRGTLCLPAHGVGAVPAQLADGLPEGV
                     LRLETPVDMLTPEGVLLTDGRELPAASVVVATDAATAARLLPGLDVPAGRTVTTYYHAA
                     PSPPSSEPTLMVDSSGEVLNTCVLTEVASTYAPPGTALISTSVLGGDRPGAGEAVLRRL
                     TALYGTDTSQWRQVAVYTVEGALPAMVPPWPLSRTTRLAAGRYVCGDHRATGSVQGALA
                     SGSRAARELLGDPASG"
     gene            9255..9965
                     /locus_tag="NFX46_RS17170"
                     /old_locus_tag="NFX46_17170"
     CDS             9255..9965
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849740.1"
                     /locus_tag="NFX46_RS17170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_17170"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_252550290.1"
                     /transl_table=11
                     /translation="MDLSGARVLVAGATGVLGGALTAELAGRGACPALAGRDPARLAHV
                     AQACPGAPTVLFDAYDPASCARAVHDAKAALGGLDAVVAAFGAVAFGRAAEVGDEVAEH
                     LYAVNVLAPAALFRAALTVMGPGSVIAAFTGVVAERPQAGMADYSASKAALSAWLGAVR
                     REVRTSGIHVLEARPGHLDTGFADRPVAGTAPPMPAGGDPHRVAAALADAMETDAELLF
                     TAPDGTPVVERRAR"
     gene            10001..11185
                     /locus_tag="NFX46_RS17175"
                     /old_locus_tag="NFX46_17175"
     CDS             10001..11185
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325002.1"
                     /locus_tag="NFX46_RS17175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_17175"
                     /product="lycopene cyclase family protein"
                     /protein_id="WP_252550291.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 9e-102, bitscore:
                     339.8, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVIVGGGAAGLSLAHRLTASSSPTVTLVEPPDGPLRPPDRTWCYW
                     DRGTADLDEAVSASWTRLRVHGTDGRAITVHPSPLTYRMLRSTDFERLVHHRLSTSPGV
                     RILRATADVVRNTADGAEVRCTGPDGRTLWLRARHVFDSRPRRTLPPARTRLLQHFRGW
                     FVHTETDRFDPEVADLMDFRVPQPRHGLAFGYVLPLAPDRALVEYTEFSRTALTTEAYE
                     TALAHYCRDVLRLDAFTVESAEQGAIPMTDARFARQVGPAVFRIGTAGGATRPATGYTF
                     AAVQRQSRAIAAALHAGHAVVPPPHGRRALAMDAVLLRALDEGRINGPDFFTDLFRRVP
                     PERLLRFLDGDTSPWEEWSIGLRTPVGPMLRTAVELPFLPRRSRPAPPTGESHR"
     gene            11182..11916
                     /locus_tag="NFX46_RS17180"
                     /old_locus_tag="NFX46_17180"
     CDS             11182..11916
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345142.1"
                     /locus_tag="NFX46_RS17180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_17180"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_252550293.1"
                     /transl_table=11
                     /translation="MTLLRDHELACAFDHASQTYDRLTALNPGYRTDLLRSARRLRLPR
                     AGAGLHVLDLGCGTGASTRALLRAAPRARITAVDASSGMLRRALAKQWPAQVRFQHLTA
                     EEVVTTGEGPYDAVFAAYLFRNVTDPDGVLAAVRSLLRPGGRLAVHEYSLSGSAVHRAL
                     WTAVCQAVIIPAGTLSGDRALYRHLWRSVLAFDTVPAFTARLSDAGFTGVRAAPVAGWQ
                     TGIVHTFLASRDDASPYAEDAR"
     gene            11913..13466
                     /locus_tag="NFX46_RS17185"
                     /old_locus_tag="NFX46_17185"
     CDS             11913..13466
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978679.1"
                     /locus_tag="NFX46_RS17185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_17185"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_252550296.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.5e-06, bitscore:
                     26.5, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 4.6e-13, bitscore: 48.3,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSARRQAARRGRDRKAEIIMPPPGRDRFDREDAPSVAVVGAGIAG
                     LAAATLLAERGARVTLYEREDSLGGRLTGWHTRLSDGSQATMSRGFHAFFRQYYNLRGL
                     LRRTDPGLDRLRPLPDYPLRHSGGLTDSFARVPRTPPFSALGFVVLSPTFGWRDLVGMD
                     ARAALPLLDVRVPEAYERFDDMSATAFLERVRFPEAAHHLAFEVFSRSFFADPRELSAA
                     ELLLMFHIYFLGSAEGLLFDVPDEPFPQALWEPLGDYLQSLGAVIRTGTPVRGVHPDDA
                     GGVEVRTDNALDRYEAAVLALDPGALREVVAASPGLGTPVWRDDIASLTTAPPFLVSRL
                     WLDRPVRADRPGFLGTSGFDGLDNISVLDRYEGEAARWAARSGGSVVELHAYAVAAGSA
                     PQTVQNRLIDSLHRVYPETRQARILDARHAWRSDCPFFPVGSHTRRPTVLTPHPRVTLA
                     GDAIRSDLPVALMERAATTGFLAAGALLADWGVRGQTLWTVPRAGRSTALRALSRVGNR
                     "
     gene            complement(13753..14760)
                     /locus_tag="NFX46_RS17190"
                     /old_locus_tag="NFX46_17190"
     CDS             complement(13753..14760)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524373.1"
                     /locus_tag="NFX46_RS17190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_17190"
                     /product="DUF5914 domain-containing protein"
                     /protein_id="WP_252550298.1"
                     /transl_table=11
                     /translation="MSDRADRTRWTPPLRRRRRSDWATQTPTWREARPALIADALERAS
                     ARPSGNWFVVGASRDVRAGGRPYGRTVGGVEVVLWRSDTGDLRAGPGSCPHLGAPLRDS
                     RVVCGTLVCHWHGLALDDGAFAGWRPYPVHDDGVLVWVRLDAVGGEEPSEHPVVPARPA
                     ARSGVDAVFTAVGRCEPQDVVANRLDPWHGSWFHPYSFVDLTVARPPQGPEDDVFVVDV
                     SFRVTGRLVVPVRAEFTAPGPRTVVMRITEGEGSTSVVETHATPVTGKSAQRPRTAVVE
                     AVVAASDRRGFALARAAAPVLRPLMRRTAGRLWRDDLAYAERRWELRSSGRFPG"
     gene            complement(14757..15755)
                     /locus_tag="NFX46_RS17195"
                     /old_locus_tag="NFX46_17195"
     CDS             complement(14757..15755)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019979883.1"
                     /locus_tag="NFX46_RS17195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_17195"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_252550301.1"
                     /sec_met_domain="phytoene_synt (E-value: 8.4e-124,
                     bitscore: 411.0, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 3.2e-64,
                     bitscore: 215.9, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRELDAAGITDPALRAAYTECRRLNARHGKSYFLATRLLPVER
                     RSAVHALYGFARWADDIVDDLDRHRTPRERDRRLLRLEDDLAHGLRTGTGNEPVVRAVA
                     DTAERYDIEHTLFADFLASMRSDLHVTDYPTYADLRTYMHGSAAVIGLQMLPVLGTVVP
                     REEAAPHAAALGVAFQLTNFLRDVGEDLDRGRVYLPADLLAAHGVDRPMLEWSRRTGRT
                     DPRIRAALVAAEDLTRKVYRAAEPGIAMLDPRTRPCIRTAFALYGGILDAIADQGYTVL
                     QRRAVVSRVRRAATATAGVVQIAGARWRAVRTDRRAPQPGVTPLPWKGPVK"
     gene            complement(15742..17313)
                     /locus_tag="NFX46_RS17200"
                     /old_locus_tag="NFX46_17200"
     CDS             complement(15742..17313)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019979882.1"
                     /locus_tag="NFX46_RS17200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_17200"
                     /product="phytoene desaturase"
                     /protein_id="WP_252550303.1"
                     /sec_met_domain="DAO (E-value: 2.6e-16, bitscore: 59.0,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTVAGPTDHVVVVGAGLSGLACALHLLGAGRRVTVVERDDGPGG
                     RAGRVRLGGYEIDTGPTVLTMPHLADEAFAAVGDSLDRHVELTALHPAYRACFADGSSL
                     DVHTDGEAMEAEVRRFAGPAEAAGYRELRDWLERLYRAQMRRFIDTNFDSPFQLLHPDL
                     ARLAALGGFGRLDRRISRFLADPRLRRVFSFQALYAGVAPARALAAYAVIAYMDTVAGV
                     WFPKGGMHALPRGMANAAAQAGAEFRWSAEATMLERSGDRVRAVRLASGESIRCDAVVL
                     TCELPAAHRLLGRAPKRPVRLRHSPSSVVLHAGTDRTWPGLAHHTLSFGAAWERTFDQL
                     TRTGELMSDPSLLITRPTTHDPGLAPPGRHLHYVLAPCPNTDVGPSGAEWRDLGPRYRD
                     SLVTELERRGLDGFADSVQEELLVTPLDWTAQGHAAGSPFSVSHTFAQTGPFRPRNLVR
                     GLENVVLAGCGTTPGVGVPTVLISGKLAAGRVTGGRTGIRHVHTSPARRGTRAVAPTAE
                     GAHDPS"
     gene            complement(17310..18452)
                     /locus_tag="NFX46_RS17205"
                     /old_locus_tag="NFX46_17205"
     CDS             complement(17310..18452)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345137.1"
                     /locus_tag="NFX46_RS17205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_17205"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_252556534.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.4e-45, bitscore:
                     153.7, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGLRPTVAEPVGRADGPLTAREGARAAEAELGRVLDDVLGRARE
                     ADPVFARDIADRVASLVLRGGKRLRTAFAWCGWRAAGGTGDATPVLRTGAALELVQACA
                     LIHDDLMDGSPLRRGAPAVHVDLARMHETARMTGSPETFATSAAVLAGDLALAWADDLM
                     TETVLGSPHGPQLHREWQAMRTEMVAGQYRDIHAQATGASGVDEAVTIATLKSALYTVE
                     RPLALGASLAGADATVLDALRSAGRCAGLAFQLRDDILGAFGDPAETGKSSEDDLRTRK
                     LTYLLAVGSRLAEASGDREAADVLAPGAPSVSDDAVRRMRAALERTGARAVVESKVTEL
                     AATSLRHFDRTGAEPSVRREFAALVGRASGMAPHRTGEAA"
     misc_feature    18416..18430
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     gene            complement(18588..20084)
                     /locus_tag="NFX46_RS17210"
                     /old_locus_tag="NFX46_17210"
     CDS             complement(18588..20084)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018843427.1"
                     /locus_tag="NFX46_RS17210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_17210"
                     /product="cryptochrome/photolyase family protein"
                     /protein_id="WP_252550306.1"
                     /transl_table=11
                     /translation="MHWLFGDQLGPHFLTPGDDGPGRDTPLLMIEARSVFRRRRFHRAK
                     AHLILSAMRHRAAELGERMTYVRADTYRQGLEEVAGDRPVTVHHPTSYAALRLVRSLPQ
                     VTLSPARGFLVPMDDFAAWADGQGGERLRQEDFYRWVRKGHDLLMDGDAPAGDRWNLDH
                     DNRQPPPRAASTLQVPAPFRPREDDIDDEVRHDLDRWERDGDVAFVGRDAPRAFPASRA
                     EARAALKRFLTHRLPTFGPYEDAVLAADPVMSHSLLSSSLNLGLLDPAECVERAEAEWR
                     AGRAPLNSVEGFVRQIAGWREYVWQLYWYFGEDYRRSNVLCHTAALPHWWSELDADAVE
                     ARCLRTVLSQVRDTGWTHHIPRLMILGSYALQRGWDPAAVTDWFHRCFVDGYDWVMVPN
                     VVGMSQYADGGRMTTKPYTSGGAYVHRMSDLCGPCRYRPGDRTGEQACPYTAGYWAFLD
                     RHRERLGRNHRTARPVHQLGRLTDLPEVRRQEGDRGDAPP"
     gene            complement(20534..22099)
                     /locus_tag="NFX46_RS17215"
                     /old_locus_tag="NFX46_17215"
     CDS             complement(20534..22099)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324500.1"
                     /locus_tag="NFX46_RS17215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_17215"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_252550308.1"
                     /transl_table=11
                     /translation="MAATDGQRNGERLRCLVTGASGYIGGRLVPELLQAGHRVRCLARS
                     PDKLRDHPWTQDAETVRGDVTDAASVAKAMRGVDVAYYLVHALGTGSTFEDTDRRAARI
                     FAEQAHAAGVRRIVYLGGLTPKGVSERSLSPHLRSRAEVGRIFLDGPVPATVLRAAIVI
                     GSGSASFEMLRYLTERLPVMVTPSWVHTRTQPIGVHDVLRYLVGSATMPPDVDRAFDVG
                     GPDVMTYQEMMRRYATITGLRRRLIVPVPVLTPRLSSHWVGLVTPVPASIARPLTESLR
                     HEVVCHEHDIARYLPDPPGRPLPFDEALALALRRVRDVQVATRWSSDAVPGAPSDPLPT
                     DPDWAGGSLYEDDRHLPVDASRASLWEVVEGIGGDNGWYSFPLAWAVRGWLDRFVGGVG
                     PRRGRRDAERLRVGDPLDFWRVEEIEPGRLLRLRAEMRLPGLAWLEMYVETDTAGRTRY
                     RQRTLFHPRGLLGHAYWWGVAPFHSVVFGGMARNIAQAAAKKASAPGRAPRTGHARFVR
                     IIRR"
     gene            complement(<22621..>22731)
                     /locus_tag="NFX46_RS17220"
                     /old_locus_tag="NFX46_17220"
                     /pseudo=""
     CDS             complement(<22621..22731)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019329063.1"
                     /locus_tag="NFX46_RS17220"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="NFX46_17220"
                     /product="short-chain dehydrogenase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDDIRATSGLASVVLANAGAAEGGPFAESDPAVWRRV"
     gene            complement(22946..23926)
                     /locus_tag="NFX46_RS17225"
                     /old_locus_tag="NFX46_17225"
     CDS             complement(22946..23926)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012792.4"
                     /locus_tag="NFX46_RS17225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_17225"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_252550311.1"
                     /transl_table=11
                     /translation="MIPPAEERQRGTGPVSVRPLGEADLDRADEIFRVAFGTFLGAPEP
                     KTFFGTADYVRTRWAADPHAAFAATVEGEVVASNFAVDWGSVGYFGPLTVHPDLWDQGI
                     GRRLMEPVMECFETWGNRHLGLFTFSHSAKHLELYRRYGFWPRFLTAIMKKQVAGSTAV
                     PGRVLYGELPAAEQLDALGLCRTLTGAVFEGLDVEREIVATHAQGLGDTILLQGAGSDL
                     DGLAVCHCGPGSEAGDDVCFVKFGAVRPGPEAADRFERLLTACERLAAERGLGQLDAGT
                     NLARQDAYRRMVDRGFRTWLQGVAMHRPNEPGYSHPDAYVIDDWR"
     gene            complement(24342..26453)
                     /locus_tag="NFX46_RS17230"
                     /old_locus_tag="NFX46_17230"
     CDS             complement(24342..26453)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018854274.1"
                     /locus_tag="NFX46_RS17230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_17230"
                     /product="MMPL family transporter"
                     /protein_id="WP_252550314.1"
                     /transl_table=11
                     /translation="MRSTPRWARWLVPLVLLVAWLGVGGTLGPYAGKLGEVATNDQAAF
                     LPQSAESTKVLKAREAFDQSETLPAIVVWTADDGRVTEAQRSSATRAIDGLAGRSGVVG
                     APSPALPSEDGKALQAVVQLEPDLGDGLPDVLSEVREAARSVPGATAQIAGPAASQADL
                     SDAFAGIDGLLLGVALAAVLLILLLVYRSILLPFLIILGSVFALGLACGIVYVLADHDV
                     VRVDGQVQGILSILVIGAATDYALLLAARFREELVLREDPSSAALAAVRRSFGAIAASA
                     ATVALALLALLASDLTNNRALGPVGAIGIVCAALSSLTFLPAVLALLGRSAYWPSRPKA
                     SDASDRGHGVWRRVAALVDSRPRRIWVVTALGLAVFAAFSPSLSAKGVPLDEIFVNDAP
                     SVAAQQTLGEHFPGGSGNPAIIVADADRTAQVTAAARETEGVASADAVSASGRPGAREP
                     LVVDGRVRIDATLEASADSDGAKETVERLRANLHAVPGADALVGGYTAQQYDTQQTAAR
                     DRTLIVPVVLVIILIILVLLLRSLLVPLLLVATVALNFLATLGVSALVFEHLLGFSGTD
                     ASVPLYGFVFLVALGVDYNIFLMSRVREEALAHGNRQGVLRGLTTTGGVITSAGVVLAA
                     TFAALMVIPLAFLVQIAFIVAFGVLLDTLVVRSLLVPALVLDIGPRAWWPSHLAHEDTG
                     PAAGRQPST"
     misc_feature    complement(26495..26509)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.25"
                     /tool="antismash"
     gene            complement(26723..27595)
                     /locus_tag="NFX46_RS17235"
                     /old_locus_tag="NFX46_17235"
     CDS             complement(26723..27595)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018513152.1"
                     /locus_tag="NFX46_RS17235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_17235"
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_252550317.1"
                     /transl_table=11
                     /translation="MPLRFTTRRSRERRRREADHRFGVRLLGAAVVAALAAVAFGLLVV
                     LVEGRWQPLRRLDASAARRLNETALDHPAWTGTLRLLSDWVWDPVTLRVVVALLTLWLL
                     RRGAWRLAAWSAVTAVAGGLIGVLVKVVVERARPTLEDPVAHAPGFSFPSGHAMTATTS
                     FAILLLVLLPMVPRAWRAGCWCFAVLSVLGVGFTRVALGVHWFSDVVGGWLLGLVVVAL
                     TAGAFEAWRADIGRRTTELADGLEPELSGPHPEPSMSSPPTRGRTAPGPGGHRAGGPAS
                     GAKVFRRHR"
     gene            complement(27714..28103)
                     /locus_tag="NFX46_RS17240"
                     /old_locus_tag="NFX46_17240"
     CDS             complement(27714..28103)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NFX46_RS17240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NFX46_17240"
                     /product="hypothetical protein"
                     /protein_id="WP_252550320.1"
                     /transl_table=11
                     /translation="MGTATEFPEAKDMTGEELCPDEALVALCRYGRRPLPRDAFVRLLH
                     ADGFTPSRALALRTVLSVLSVLSVTRYGAARLAVDGCTVPAGIPPAIAFVGLSTAPHPE
                     DIGRFAELAIHRPTTSARRSARGSS"
ORIGIN
        1 ccacatcggc gggcttcgcc ccgagttcct tcagacgtgc gaccaactcc gcctgatggg
       61 cgtcggaggt ggtggccagc tcgatgtgca cgcggtactt caccgtctcc gggtccggca
      121 cgcggacgag atcgatgcag acggcggacg ggtccggcca gtcgaagccc acgggttcca
      181 ggttggtgac cccgggccct tcgctggaaa caccccagcc gagcacctcc gcccagaacc
      241 ggccgagcgc cgagtcgtcc cgggccttga agttcacctg aacaagttgc agcgtcatgc
      301 cgcgtacttt aggtgatctt ccatcgggca cacgtgcgaa cggaatcggc cggcaccctt
      361 cgctcggtcc cgtggacgac tggcgcggac agccctacag gagagggcag ccggagggca
      421 gggcgtcgta gggaagcgcg gcggccgagg caggcggtat ccgggatcac acagcgccgc
      481 acatgtgcct tgaggcactg cgctcacacg ttccggccca tgcccccgac gccatcgcca
      541 acgtcttgct ccggggaggg agccgacgct gtcccgtggg aagcgcacga tgcggggaca
      601 tcgccggccg tcccgtgtcg caagggtggt ggctccggcg tcacgcagcc ggttcggcag
      661 tggaggccga ccggtccgcg ccccgccgga gccacacgaa ggtgccggcc gtcaggcggt
      721 ggccgggctc cacaggtcgc acttgtggtc cgtggggaag gtgagcaccg aggtgatcgc
      781 ttccggggcg aggacctgca ccttggggaa gaggtcccaa cgaggcgctt tcgcggcgta
      841 cgggacaccg gtcctggcga agttggtcca gtagccgagc atgctgtccg acagggcgtt
      901 ctgggcgggt gtgcctgaga cgctgccgaa gacgtaccgg atctccgagc cgtgcggtgc
      961 gccgatcggg aagctgatcg gcatgttcag gtagtccatg gcgtgacggt ccgcgaactc
     1021 gtactggtag gagcgggtgt gctcggccat caggctcgcg gtgcgggatt gcaggcaggc
     1081 gaactgcgag tcggtgagga ccgcgccgag agcctccgcg ggcgtgccgt agtccgacag
     1141 cgggtagcgg gccaggatct cgtcggctcg ttcaccgtgg agcgcgcgga ccgccaccgg
     1201 gtagcccgcg gcggtgagct gccggccggc caggtcgtag gtggtcgcca ccgtgagccg
     1261 gccttcgtcg gcggtggtgc cctgaaggac ggggacgcgg tggaagcgtc cgatgtccag
     1321 ggcgtccggc acctgcaggg ggaggacctt gccgtcgacg ttgggcgtcc agcgggcggt
     1381 gggggcggcc gaggccgtga gcagttcctg cgcggtcctg gttcgcaggc aggccgcgtc
     1441 cgcacagccc agggagtcgg cccaggcctg cccgttgttc tgctgcgact cctgggtggg
     1501 cagggggaat ccgcagccgg actgggcgat ggcccggtcg aacaggccgg tcgtgcgggg
     1561 cgagaccagg ttctggcaga cgctgccgcc tcccgccgac tcaccgaaga tcgtcacgtt
     1621 gtcggggtcg ccgccgaacg ccacgatgtt gtcccgcacc cagcgcaggg cggcctgctg
     1681 gtcgagcagg ccgtagttgc cggagattcc ctgcgccgac tccttggcca ggctcgggtg
     1741 ggcgaggtag ccgaaagcgc cgagtcggta gttgaggttg acgaccacca catcgccctt
     1801 ggccgccagg ttgccgccgt cgtagaacgt gccggagccc acggtgaagc caccgccgtg
     1861 gatccacacc atcaccggtc gcttctggag ggagcgctgc gcgggtgtgt agacgttcag
     1921 gtacaggcag tcctcactcg gagtgccggg tcccgctaga tcgccccaag ggctggactg
     1981 gacgcgctgc acgcaggggt tgcccggagt gcgggcgtcc cggattcccg accatcgcgc
     2041 gggcgggacg ggcggcctcc accgcaacgg cccggtcggt ggtgcggcgt agggaatgcc
     2101 gaggtaggag gtggcggtct cgcccacctt cccctggacc tgcccgtacc gggtcgtgac
     2161 gatcggtccg tcggccgcgg cggcgggcgc ggaggtcata gcggtggccg acagcagcag
     2221 ggcgaccgcc ggcaccacca ggcgtcgggg cgagagccat cgtcgacggc atgtcgtcga
     2281 aagtcttgca agcggaccgg acatcggcac ctccgtgcgg aaggacgaca acggactcga
     2341 agtctcgtca gccgtccggc gcccgggacc gcgtaaacca ccagtctcga ccggtgacgt
     2401 ccttccgcgg ccccgaagga catgcgcacg gacgaatcgc atcggacacg cgcgcgccgt
     2461 tcggccgtac ggacgcccgg gctgtgaggg gagcagcagg gtgcgagagg ccgcggttgc
     2521 cggtggcact gggccccgga agacctcggg cacgaacagg gcgacctcgg agcggacgtg
     2581 aaggcgaccg accccctggg actgaggggg acttcgtccg gcgtacacgt gacggccgcc
     2641 gtccgcccac gcgccgcggc tggtacggcg gcgcccgctg gccggtcctg tgagcggagc
     2701 gcgaggccct caggcgtcac ccgtcccggt gatcacccgc gaggttgctc ccacaccgtg
     2761 tggtgcacag ccaccctgaa ggcatgcgtc acccgctcgc cctcatcccc gccctggctg
     2821 ccgccctctg cgtcggcttg tgcgtatccg tccccacggt cggcccgcct gagcccccgc
     2881 cttcgctgat ggcggccgcg gcgcggacgc cgtcgcccgt gccgtctccc agccggccgt
     2941 cacccgtacg ccgtctcggg tgccggccgt gagccagccg tccgcccgca ccgccctcgt
     3001 cacgaccgac accatcccga tgctgagggg cagcggccgc gaagccgcag cagtggagga
     3061 gcagcgttcc tcaagggtcc ccactcccca acagcggtcg cggacccgtg caccggagcg
     3121 gccgcggacg gctgcgccac ccgtgccggc ccgtccccgg gctcggccgg cggccccggc
     3181 cgcgccccgt ccccgggtgg tcccgcctcg ccccgcacag ccgccgaccg ccacctacgg
     3241 cctgaagtcc ctgtgcggac tgtcgcacca ggcgcccgtg ccgccgtccg tgaaggggct
     3301 ctgtgacgcc tacgtccgct gaggccaggg cgcggtggtc gcgaggacgt ctacagcgct
     3361 gtcgtacgcg gacgaccccg gagtacctct ggttgatcga tgccgagcgg cccgaggtct
     3421 ggccccagcc tcagacctgg cgtgggccgg tcacgcgaca cgcggcctcg aggaggccat
     3481 cacgctgagg agcgcgggtg gttctcgtcg cgccaggccc gcggcgagat tccgtatgcc
     3541 tgtttgaaca ctttgctgaa gtgggtcgcg tccgcgaagc cccaacttcg tcctatcgcc
     3601 gcgacggtcc gcaggcggcc gttcgggccg gccagctctc gcctgcattc ggccaggcgg
     3661 cgtgtacgga tccagtctcc gaggctgatt cccgaccggg acaggacagc gtagaggtga
     3721 cgtacggaga tgccctgtgc ggcggcgatc cgcgccgccg acagatcggg atcagccaag
     3781 tgctcccgga tgtactgagt gacccgcagg ccgagtgtcg cctccaacgg ccccttggcc
     3841 aggctggacc tgccgtgctg ggacgtcagc acggcacgga ggagttcgac gctgggttcc
     3901 acgacggcat cggcgtgcac accctggtgc aactcgtcgc tgacggccag ttgggagaag
     3961 taggtgaagg cgaggcgcgc aacggggttg tcggatccca aggtcaccgt ggtggtgtct
     4021 cgtagcaacc ggtcggggag cgccagggcc gcgcggggga aacgcaggaa gtggtgatcg
     4081 actccctcgt cgaagagaag tgtgtagggc gcgatcgact cgtagacggc gaattccccc
     4141 ggcctcagta cgcactcgcg accgttctgc gccaccaggc tgctgcccgt cacctgcagg
     4201 ccgaggaaga cggccggctc ctcgtccttc cgggccagcc gctccgtccg acggatggtg
     4261 accgcggtcg cccgcgccga gcagatcctg agggggccga cggtgccgag ccctgtgcgg
     4321 acggagatgt cctcagccgc aggacggtgg tcgatgtcga ccgccaccac ggattcccat
     4381 accgcgtgcc ggatcacttc ctcccggtcc cgcggcggta tgtacgcggt gtccaggacc
     4441 gagctcatgg ggcagacctt cgtccgtctc gctcatagag ccggcctgac agtgcgtcgg
     4501 cccgttcccc cacaagtcac ccctccacac ggatggttcc ggccatcagt ctgtcgggat
     4561 tccctcttgc cccgcaatgg ctccagacgg gcatacgctg gaccttcgcc tgatgtggcg
     4621 tcagttcgag gtggaggggt ggagggcagc cctgacgaag ttccctgccc gcaggacacg
     4681 gagcgcacga tgaccccaag gtccaaggca gctcggacgc cgtgaaggcg ctggagggcc
     4741 atccttcgcc gctacggcaa cacccctgcc gccgatcgga tccgcgccgg cggaggggcg
     4801 gacgggctct gcggcaccgg cacggtggat gccgttcggt ggctccagac aaaccgcctc
     4861 ggcgtgagtg ccgccggcgt ctacgggccg gcgaccgtcg gggatgtggt ggcgggccta
     4921 ttggcacgcc ccgacgacgg atccggtccg ttgctttggt cagctgctac aacccgccgt
     4981 tccagtccca cgacgacgcc tgtcgacgcc gacctccgtg cgggaagccg acgtcgaccc
     5041 cgtccgacgc ccgggtccag ccgggacggc ggacctggac ggcccccgcc tgcccctgcg
     5101 cccgcaggac gagcccggct cggctgaccg gaccggctgc gtcaggtgac acggccggtc
     5161 accgcggcgt tcgcatgctc cgagtgccga gtgccgagtg ccgagtgccg agtgccgagt
     5221 gccgggtgcc cagtgcccag tgccagtgcc agtgcccaat gccgggtgcc gagtgcagag
     5281 tgctgggtga cgggtgccga gtgggatccg gttctcacac gggcgggtga tcgctcgccg
     5341 attcggatgg cctgaacgat cgcttccgcc tgcgccacca cacgatcagg aggctggcga
     5401 gcaggccgca cgccaacggg gtccttcggc tcccggtgcc cggggaacgc ctgtgacggg
     5461 agtcagccga caccgccgga ggcccgcgca gcgacgccgc cgggggcggc ggggtggctt
     5521 cgcatggctc tgccagttct tgtgcgatgt gctgccacac tcgctccgga gggcatgcga
     5581 ggagatccgg ctcctgcacc gagcgggcgg cggtgatgac ccaggtcgtc aggcgcagtt
     5641 cctcctcgca gcgctcgcac acgccgatgt gctgccaggc actgacgtcg ttgtgcgagg
     5701 cgtcgtgtcc cagcgccagc tccaccatgc gcgtcgggtc gatgtgcggc accgccatct
     5761 cctgttcgtg tgaggcgtga cctgccccta cctgtaccga ttggtggccg cccacggatg
     5821 cactcacccc gtccgagccg gtgaccggct ccgcggtgac gatcggatgt gcctcgtgac
     5881 ggccgtcctc gcggacgaat ggaggggcgc ctacgccgtg ttctcctcgg cgcggccctg
     5941 ttcgactgcc tcgcgcagtc ggtgaaggcc acgtcgggtg tggctcttca ccgtgcccag
     6001 gggcataccg gtgcgttcgg cgatctgagc ctgggtgagg tcctggtaga agcccaggca
     6061 cagcacctcc cgctggccgt gcgggagccg ggacagcgcg tcgaccagga gtacgcggtc
     6121 gaggaccccg tccgtcgtcg cgcctacctc gtgtcgccgc ccgtcggcgt cgtgggtgac
     6181 ggtctcgatg agggtgaggc gcctcgtccg ggcggcgagc gcgtcgacga tcttgcggcg
     6241 ggtgatgccg acgagccaac cgccgagcgg ccccttctcc gggcggtagc cgttccgtcc
     6301 gcgccaggcg ccgaggaaca cctgctgggt cacgtcctcg gcctcgaacg tgtcaccgag
     6361 tgaacgcgtg gccatggtgt ggacgagtga gccccagcgc cggtacacgg ctgcgaacgc
     6421 gttctcgtcg gcggcgagca gaccacgggc gagttcctcc tcgtaccggg cctcctgcgt
     6481 ggcgggagta cggacgccgg tgtgtcgcac gttcgtggtc atgcccttgt tcctcctgcc
     6541 gtccgtgctg tgtgtggcgg aaggccgccc gtggagcggg ccagaacggc gtgtgctccg
     6601 ttgtcaccgg ctcgtgtgcc agtgttctga agggaaacga cgcagacaac gtgcgtcgct
     6661 tgtgcgtcgt aagctcggag gatggacctg gacgagggcg acggtggcga ggcggaagtg
     6721 cgacgcggtg gcgggatgtc caccggcgag gtggcgaggc gtctgggtgt ggcgccgacg
     6781 acggtccgtt catgggaccg ccgctacgga ctcggccccg ccgcgcacac cggtggccgg
     6841 caccgccgct ggaccgccgc cgacctggct cgactggagc ggatgtgcgc tctgacggca
     6901 accggcctgc caccggccga ggccgcccga ctggccctcg acgagacggg ttccaccacg
     6961 cccccgcgtg aagcggacag ctcgcctgtc ccgcagtcgg tggcccgttc gcgcagccgg
     7021 gccggaacgg gtctgcggct cgacgacgtg cgtcaggagt gcaagggggt cgcccgcgca
     7081 gccctgcgcc tcgacgccac cgccctcgac gagctgctga aggacgcgat cgggcaacac
     7141 ggcctgatcg cggcctggac ggaggtgatc atgccgacgc tgcaggcggt cggtcgtaag
     7201 tgggagagct cgggggagcg ctacgtcgag gtcgagcact tcctgtcctg gcacgtctcc
     7261 ggcgcgctgc ggcgccactc gccccccgtg ccgaccgacc ggcccggtgc caccacggtg
     7321 ctcgcctgcg tgcccgcgga gaaccacacc ctgcccctcg aggtgctggc cgccgcgttg
     7381 accgaacggg acctgccgat acgcatgttc ggcggctcgt tgcccgtgga gtccctcgtg
     7441 gccgcggtgc gcaggaccgg accggccgcg gtgtgcctgt gggcgcagtc ccgtaccacc
     7501 gccagccggc cactggccca gcacatcgcg gcgatcgagt ggggcgtgcg cggggcccgc
     7561 aggaagccgg tcgtcctcac gctcggcccg ggctgggccg ggcagaccac accgggactg
     7621 ccgcaccctc ccgggttggc ggaggccgtc gccgcggtcg agtccgccat gcgcaggtga
     7681 ggtgacgccg ctcatcgggt acgcgcacgt cgtggcgccc gccctcaccg ggcagaacgt
     7741 gctcgggtgg acgtcgtgag caggcgtcct gcgttcctgg aacgacgcgg caccgacgac
     7801 gcaccccgtg ccgggcgagt gcggtgcgac ggagcagcgc aggaccctca gcgagtccac
     7861 cccgcctctc gctccgcgaa ggccggcgcc gaaggaaaag ggaacatgag cagtcaacaa
     7921 cgcggcaccc ccgacaccgt cgtcgtcgga gcgggcctcg ccggtctcgc ctgcgcgctg
     7981 gacctgtgcc gtgccgggcg gagcgtgacg ctgctcgagg cgtccgacgg cgtgggcggc
     8041 cggatgagaa cggaccgcag ggacggcttc ctgctggacc gcggctttca ggtgttcaat
     8101 acctcgtacc cgcaggtcaa gcgtcgtttg aacctccgga acctgcagtt gaggcccttc
     8161 acgccgggca tcatcgcgcg cacctcgacg ggagacgtac gcctggccga tccgacccgg
     8221 cagccgcggg cggcgaaatc actgctaccg gggcgtgtcc tgtcggcagg ggacctggcg
     8281 gccatgggcg cgctcacggc gagggacgcc ctcctgcccg ccgccctcct caagcaccgc
     8341 ccggacaggt ccaccgccgc ggccctctcg cgagccggtc tgtcggaacg aacggtctcc
     8401 gagatcttga ggccctttct gtccggggtg ttcctggagg accggctgga gacctccgcc
     8461 cgcttcttcc acctggtctg gcggagcatg gtcaggggga cgctctgtct gcctgcccac
     8521 ggagtcggcg ccgtgcccgc ccagttggcg gacggtctgc ccgagggcgt tctgcggctg
     8581 gagacgcccg tcgacatgct cacccccgaa ggagtgcttc tgacggacgg ccgtgagctg
     8641 ccggccgcgt ccgtcgtggt ggcgacggac gcggccaccg cagcgcgtct gctccccggg
     8701 ctggacgttc ccgccggccg gacggtcacc acctactacc acgcagcccc gagtccaccg
     8761 tcgagcgaac ccaccctgat ggtggacagc tccggcgagg tactcaacac ctgcgtgctg
     8821 accgaggtgg cgtccacgta cgcgccgccg ggtaccgcgc tgatctccac gtccgtgctg
     8881 ggaggggacc ggcccggggc gggcgaagcg gtgctgcggc gcctgaccgc gctctacggc
     8941 accgacacga gccaatggcg gcaggtcgcc gtctacaccg tcgagggggc cctgcccgcc
     9001 atggtgccgc cgtggccgct gagccgtacc acgcgtctgg cggcgggccg gtacgtctgc
     9061 ggggaccacc gggcgaccgg cagcgtgcag ggcgcgttgg cctcgggcag ccgggctgcc
     9121 cgggaactgc tcggtgatcc ggcgtccggg tgagagccga gcggatcgcg ggagctgcat
     9181 ccggacgcgg tcgccgcacg gaacagacga tggaggcaaa gagccggtga ccttcctgcg
     9241 agtgggagaa gagtgtggac ctcagcggcg cgcgcgtgtt ggtggccggc gccaccggtg
     9301 tcctcggcgg tgcgctcacc gccgagctgg ccggccgtgg agcgtgtccc gcgctcgcgg
     9361 gacgcgatcc ggcccgtctc gcccacgtcg cccaggcgtg tccgggggct ccgaccgtgc
     9421 tgttcgacgc gtacgacccc gcgtcctgtg cccgcgcggt gcacgacgcg aaggcggctc
     9481 tgggcgggct ggacgccgtg gtggcggcct tcggcgcggt ggccttcggg cgggcggcgg
     9541 aggtcggtga cgaggtcgcg gagcacctgt acgcggtcaa cgtcctcgcg cccgccgccc
     9601 tcttccgcgc cgcgctcacc gtcatgggac ccggttccgt gatcgccgcg ttcacgggcg
     9661 tggtcgcgga acgcccgcag gcgggcatgg ccgattacag cgcgtccaag gcggcgctga
     9721 gcgcctggct cggcgcggtg cgccgcgagg tacggaccag cggcatccat gtcctggagg
     9781 ccaggcccgg acacctggac acgggcttcg ccgatcgccc cgtcgcgggc accgccccac
     9841 cgatgccggc cggaggcgat ccgcaccgtg tcgcggcggc cctcgccgac gcgatggaga
     9901 cggacgccga actgctgttc accgcccccg acggcacgcc cgtagtcgaa cggcgcgcca
     9961 ggtgagccga cagcccccca catccggagg gccgtgcgac gtggtcatcg tcggcggcgg
    10021 cgcggccggt ctcagcctcg cccaccggct gaccgcgtcc tcctcaccca ccgtcaccct
    10081 cgtggagccc cccgacggac cgctgcgccc tcccgatcgg acctggtgct actgggaccg
    10141 cggcaccgcc gacctcgacg aagcggtcag cgcctcctgg accagactgc gcgtgcacgg
    10201 caccgacggc cgcgcgatca ccgtccaccc gtcgccgctg acctaccgca tgctccggtc
    10261 gacggacttc gaacggctgg tccatcaccg gctcagcacg tcccccggcg tacgcatcct
    10321 gcgcgcgacg gccgacgtcg tgcgcaacac ggccgacggc gctgaagtgc gctgcaccgg
    10381 tcccgacggc aggacgctgt ggctccgggc gcgacacgtc ttcgactccc ggccgaggcg
    10441 cacgctgcca ccggcccgga cgcggctgtt gcagcacttc cgcggctggt tcgtgcacac
    10501 ggagacggac cggttcgatc ccgaagtcgc cgacctcatg gacttccggg taccgcaacc
    10561 gcgccacggc ctcgccttcg gctacgtact gcccctggcg ccggaccgcg ccctcgtcga
    10621 gtacaccgag ttctcccgga ccgcgctgac cacagaggcg tacgagacgg cgctggctca
    10681 ctactgccgc gacgttctgc ggctcgacgc gttcacggtc gagtcggcgg agcagggggc
    10741 gattcccatg accgacgcgc gcttcgcccg tcaggtcggg ccggccgtct tccggatcgg
    10801 gacagcgggc ggtgccaccc gtccggcgac cggctacacc ttcgccgccg tgcagcggca
    10861 gagccgggcc atcgccgccg ctctgcacgc gggccacgcg gtcgtgcccc cgccacacgg
    10921 gcggcgggcc ctcgccatgg acgccgtgct gctgcgggcc ctggacgaag gacggatcaa
    10981 cggccccgac ttcttcacgg acctgttccg ccgcgtcccg cccgaacgcc tcctgcgctt
    11041 cctcgacggc gacacctcgc cctgggagga atggagcatc ggcctgcgca cccccgtggg
    11101 ccccatgctg cgcaccgccg tcgaactgcc cttcctgcca cgccgttcgc ggccggcccc
    11161 acccaccgga gaaagccacc gatgacactg ttgcgcgacc acgaactggc atgcgccttc
    11221 gaccacgcct cgcagaccta cgaccgcctg acggccctca accccggcta ccgcaccgac
    11281 ctgctgcgtt cggcgcgtcg cctgaggttg cccagggccg gtgccggtct gcacgtgctg
    11341 gacctcggct gcggcaccgg cgcgtccacc agagctctcc tgcgggccgc gccgcgcgcc
    11401 cggatcacgg ccgtcgacgc ctcctccggg atgctgcggc gcgcgctggc caagcagtgg
    11461 cccgctcagg tgcggttcca gcacctgacc gccgaagaag tggtgacgac gggggaaggg
    11521 ccctacgacg cggtgttcgc cgcctacctg ttccgcaatg tcaccgaccc ggacggtgtc
    11581 ctcgcagccg tccgctcact gctgcgaccg ggcggccgac tcgccgttca cgagtacagc
    11641 ctcagcggct ccgccgtcca ccgcgccctg tggaccgccg tgtgccaggc cgtgatcatc
    11701 cccgcgggca cactgagcgg cgaccgcgcc ctctaccggc acctgtggcg cagcgtcctc
    11761 gcgttcgaca ccgtgcccgc cttcaccgcg cgtctgtcgg acgccggctt caccggcgtg
    11821 cgcgccgcgc ccgtcgcagg gtggcagacc ggcatcgtgc acaccttcct ggcctcccgt
    11881 gacgacgcct ctccatacgc cgaggacgcc cggtgagcgc ccgccgtcag gccgcccgcc
    11941 gggggcgcga ccgcaaggcg gagatcatca tgcccccgcc gggccgggac cggttcgacc
    12001 gcgaggacgc gccgtcggtc gccgtggtcg gcgcgggcat cgccggcctg gccgccgcca
    12061 ccctgctggc cgaacgaggc gcccgcgtca ccctctacga acgcgaggac tcgctcggcg
    12121 gacgtctcac gggttggcac acccgtctct ccgacgggtc ccaggcgacc atgagccgcg
    12181 gcttccacgc cttcttccgc cagtactaca acctgcgtgg cctgctgcgg cgcaccgatc
    12241 ccggactcga ccgcctccgc ccgctgcccg actacccgct acggcacagc ggcggactga
    12301 ccgacagctt cgcccgcgtc ccgcgcaccc caccgttcag cgcgctcggg ttcgtcgtcc
    12361 tcagccccac cttcggctgg cgcgacctcg tcggcatgga cgcccgcgcg gcactgccgc
    12421 tcctcgacgt ccgcgtgccc gaggcctacg aacgcttcga cgacatgagc gccacggcgt
    12481 tcctggaacg cgtccgcttc cccgaagccg cgcaccacct ggccttcgag gtgttctccc
    12541 gcagcttctt cgcggacccg cgcgaactgt ccgccgcgga actgctgctg atgttccaca
    12601 tctactttct gggctcggcg gaggggctgc tcttcgacgt accggacgag cccttccccc
    12661 aggccctgtg ggagccgctc ggtgactacc tccagagcct cggcgccgtc atccgcaccg
    12721 gcacacccgt gcgcggcgtc caccccgacg acgccggggg agtggaggtg cggacggaca
    12781 acgccctgga ccggtacgaa gcagcggtcc tcgccctcga ccccggagcg ctgcgcgagg
    12841 tggtcgccgc gtcacctggc ctcggcactc cggtctggcg cgacgacatc gcctccctga
    12901 cgaccgcccc gcccttcctc gtctcccggc tctggctcga ccggccggtc cgcgccgacc
    12961 gcccgggatt cctcggcacc agcggcttcg acggcctcga caacatcagc gtcctcgacc
    13021 gctacgaggg ggaggccgca cgctgggctg cccgcagcgg cggttccgtg gtggagctgc
    13081 acgcttacgc cgtcgccgcg gggtccgcac cgcagacggt gcagaaccgc ctcatcgaca
    13141 gcctccaccg cgtgtacccg gagacacggc aagcacggat cctggacgcc cggcacgcat
    13201 ggcgctccga ctgtcccttc ttcccggtcg ggtcccacac ccgacggccc accgtgctca
    13261 ctcctcaccc gagggtgaca ctggccgggg acgcgatccg cagcgacctg cccgtggccc
    13321 tgatggaacg cgcggccacc accgggttcc tggcggccgg agccctgctc gcagactggg
    13381 gagtacgcgg acagacgctg tggacggttc cccgcgccgg ccgttcgacg gcgctgcgcg
    13441 ccctcagccg cgtggggaac cgctgagagc cgttctcccg ctcaggggcg aacggctcgc
    13501 agggcccaca gacggccccg ctccgttcgc gcggaaaccg gggagacccg ggccgaacac
    13561 cgacggccgg ggagaggagt gacaccggca aggagctgcc cgccgacggc atgccgccgc
    13621 tggcgaacag cttctccagc ggaagcgggg gaggacgggc cacccctcac gcccgggcac
    13681 agatcccggc ccacgacgag agccggcccc cgaccgggca ggccgggagc cctctctccg
    13741 ccgcgctggt gatcaccccg ggaaccgacc gctgctgcgc agctcccagc gccgctccgc
    13801 gtacgcgagg tcgtcgcgcc acagcctgcc tgctgtccgg cgcatcagcg ggcgcagcac
    13861 gggcgccgcc gcccgcgcca gggcgaagcc gcgccggtcc gaggcggcga cgaccgcctc
    13921 gacgacggcc gtccgcggcc gctgggccga cttgcccgtc accggcgtgg catgggtctc
    13981 gaccacggac gtggaccctt ccccctccgt gatgcgcatg accaccgtac gaggcccggg
    14041 agcggtgaac tccgcccgca ccggcaccac cagacggccg gtcacccgga aggagacgtc
    14101 gacgacgaag acgtcgtcct ccggtccctg tggtggccgg gccactgtca ggtcgacgaa
    14161 cgagtacggg tggaaccacg acccgtgcca cgggtcgagc cgattggcga ccacgtcctg
    14221 gggctcgcac cgccctacgg ccgtgaagac ggcgtccacc ccgctgcgtg ccgccggccg
    14281 cgccggcacc acggggtgtt cggacggttc ctcgccgccg accgcgtcca accggaccca
    14341 caccagtacg ccgtcgtcat gaaccgggta cggacgccat cctgcgaacg ccccgtcgtc
    14401 cagggccagt ccgtgccagt ggcacaccag cgtcccgcac accacccggc tgtcccgcag
    14461 gggcgcaccg aggtgcgggc agctgcccgg gcccgcgcgc aggtcaccgg tgtccgaccg
    14521 ccacagcacg acctccacac cgcccaccgt cctgccgtag ggccggccgc cggcgcgaac
    14581 gtcacgggag gccccgacga cgaaccagtt ccctgaggga cgggccgagg cccgctcgag
    14641 cgcgtcggcg atcagagccg ggcgggcctc gcgccacgtc ggtgtctggg tcgcccagtc
    14701 cgaccggcgg cgccgccgca acggcggtgt ccaacgggtc cggtccgctc ggtcactcac
    14761 ttcacgggtc ccttccacgg cagcggagtg acgcccggct ggggcgcccg acggtcggtg
    14821 cggacggcac gccatcgcgc gccggcgatc tgtacgactc cggccgtcgc cgtggccgcg
    14881 cggcggactc gggagaccac cgcacgacgc tgcagcaccg tgtacccctg gtccgcgatc
    14941 gcgtcgagga tgccgccgta gagggcgaac gcggtccgga tgcaggggcg ggtccgcggg
    15001 tcgagcatgg cgatgccggg ttccgccgcc cggtagacct tccgcgtcag gtcttcggcg
    15061 gcgacgagtg ccgcgcggat gcgcgggtcg gtgcggcccg tgcggcggct ccactccagc
    15121 atgggccggt ccacgccgtg ggcggcgagc aggtcggccg gcaggtagac gcgcccccgg
    15181 tccaggtcct cgccgacatc gcgcaggaag ttggtgagct ggaaggccac cccgagggcc
    15241 gccgcgtgcg gcgccgcctc ctcacggggg acgaccgtgc cgagtaccgg cagcatctgc
    15301 agcccgatca ccgcggccga gccgtgcatg taggtccgca ggtcggcgta ggtgggatag
    15361 tccgtgacgt gcaggtcgct gcgcatcgag gccaggaagt cggcgaacag cgtgtgctcg
    15421 atgtcgtacc gttcagcggt gtcggcgacg gcccgcacca cgggctcgtt gcccgtcccg
    15481 gtgcgcagcc cgtgtgcgag gtcgtcctcc aggcgcagca gccgacggtc gcgttcccgg
    15541 ggtgtccggt gccggtcgag gtcgtccacg atgtcgtccg cccagcgggc gaaaccgtac
    15601 agggcgtgca cggcggaccg ccgctccacg ggcagcaggc gggtggccag gaagtagctc
    15661 ttgccgtgac gggcgttgag gcgtcggcac tcggtgtagg cggcacgcag ggcggggtcg
    15721 gtgatgcccg cggcgtccag ctcacgacgg gtcatgggcg ccttccgcgg tcggtgcgac
    15781 ggctcgggtg ccacgccgtg ccggactggt gtgcacgtga cggatgccgg tacgtccgcc
    15841 ggtcacgcgg ccggcggcga gcttgccgct gatgaggacg gtcggcaccc cgacgccggg
    15901 ggtggtgccg cagcccgcca gcacgacgtt ctccaggccg cgcaccaggt tgcgtggacg
    15961 gaacgggccg gtctgggcga aggtgtgcga gaccgagaag gggctgcccg cggcatgtcc
    16021 ctgcgccgtc cagtccagcg gcgtcaccag cagctcctcc tggacgctgt ccgcgaaccc
    16081 gtcgagtccc cggcgctcca actcggtgac caggctgtcg cggtagcgcg gccccagatc
    16141 acgccactcg gccccggaag gtcccacgtc ggtgttcgga cagggcgcca ggacgtagtg
    16201 caggtgcctg cccggtggag ccaggccggg gtcgtgcgtg gtcggccggg tgatcagcag
    16261 ggacgggtcg ctcatcaact ctcccgtgcg ggtgagctgg tcgaaggtgc gttcccaggc
    16321 ggcgccgaaa gacagcgtgt ggtgggccag accgggccac gtgcggtcgg ttccggcgtg
    16381 caggacgacc gaggacggtg agtgacgcaa ccgcaccggc cgcttcggag cgcgtcccag
    16441 gagccggtgc gcggcgggca gctcgcacgt cagcaccacg gcgtcacaac ggatgctctc
    16501 gcccgaggcc agacgcacgg cacggacccg gtcccccgac cgttccagca tggtcgcctc
    16561 ggccgaccag cggaactcgg cgcccgcctg tgccgccgcg ttcgccatcc cgcgcggcag
    16621 cgcgtgcatg ccgcccttgg ggaaccagac gccggccacg gtgtccatgt aggcgatcac
    16681 cgcgtaggcc gcgagggctc tggccggggc cacaccggcg tacagggcct ggaaggagaa
    16741 gacccggcgc agccgggggt cggcgaggaa acggctgata cgacggtcca gtcggccgaa
    16801 tccgcccagc gccgccagac gtgccaggtc cgggtgcagc agttggaagg gagagtcgaa
    16861 gttcgtgtcg atgaaccgcc gcatctgggc ccggtacagc cgctccagcc agtcccgcag
    16921 ctcgcggtag ccggctgcct ccgccgggcc cgcgaaccgt ctgacctcgg cctccatcgc
    16981 ctcgccgtcg gtgtgcacgt cgagtgagct gccgtctgcg aaacaggccc ggtacgcggg
    17041 gtgcagggcc gtcagctcga cgtggcggtc gaggctgtcg cccacggcgg cgaaggcttc
    17101 gtcggccagg tgcggcatgg tgaggaccgt gggtccggtg tcgatctcgt agccgcccag
    17161 gcgtacgcgg cccgcccggc cgccggggcc gtcgtcccgt tcgacgaccg tcacccggcg
    17221 accggcgccc agcaggtgca gcgcgcaggc gaggccggac aggccggcgc ccaccacgac
    17281 cacgtggtcc gtgggacccg ctaccgtcct cacgcggcct cccccgtgcg atggggcgcc
    17341 attccggacg cccgtccgac cagcgcggcg aactcgcgcc gcaccgatgg ctccgcgccg
    17401 gtccggtcga agtgccgcag gctcgtcgcg gccagctcgg tgaccttcga ctcgacgacg
    17461 gcccgcgccc ccgtacgctc cagcgccgcc cgcatgcggc gcacggcgtc gtcggacacg
    17521 gacggcgcac ccggggccag tacgtccgcg gcttcccggt caccggaggc ctcggcgagc
    17581 cgggagccga cggcgagcag ataggtgagc ttgcgcgtgc ggaggtcgtc ctcggacgac
    17641 ttgcccgtct cggccgggtc gccgaaggca ccgaggatgt cgtcgcggag ctggaacgcg
    17701 aggccggcgc accgtccggc ggagcgcagc gcgtccagga cggtggcatc ggcgccggcc
    17761 agggacgcgc ccagcgccag cggacgctcc accgtgtaca gggcgctctt gagggtggcg
    17821 atggtcaccg cctcgtcgac gccggacgcg ccggtggcct gcgcgtggat gtcccggtac
    17881 tgtccggcga ccatctcggt gcgcatggcc tgccactcgc ggtgcagttg tgggccgtgc
    17941 ggcgatccga gcaccgtctc cgtcatcagg tcgtccgccc aggccagggc gaggtcgccg
    18001 gcgaggacgg ccgcggaggt cgcgaacgtt tcgggcgagc ccgtcatgcg tgcggtctca
    18061 tgcatgcggg cgaggtccac gtgtaccgcc ggcgcgccgc gacgcagtgg tgatccgtcc
    18121 atcaggtcgt cgtggatgag ggcgcaggcc tggacgagtt cgagggccgc accggtgcgc
    18181 aggaccggcg tcgcatcccc ggttccgccg gcggcacgcc atccgcacca cgcgaacgcc
    18241 gtgcgcagcc gcttaccgcc gcgcaggacc aacgaggcga cgcggtcggc gatgtcacgg
    18301 gcgaacaccg ggtccgcctc gcgggcgcgt cccagcacat cgtcgaggac gcgcccgagt
    18361 tccgcctcgg cggcccgggc cccctcgcgg gccgtgagtg gaccgtcggc ccgcccgacc
    18421 ggttcggcca ccgtgggccg cagtcccagc atgcgcaact ccttctcact cccggtcatc
    18481 tgcacaccgt tgcttcggcg gagtggccct gtacggatgc gctgattcct gcccggttgg
    18541 cgggtcgtcc cgctgacgct cactccatcg gcccaacctc cgcctcgtca tggcggtgcg
    18601 tcacctctgt cgccctcctg gcggcgtacc tcggggagat cggtcagccg gccgagctgg
    18661 tgtaccggtc gggcggtgcg atggttgcgg ccgagccgtt cccggtgcct gtcgaggaag
    18721 gcccagtaac cggccgtgta ggggcaggcc tgctccccgg tccggtcccc cggccggtag
    18781 cggcacggtc cgcacagatc gctcatacgg tgtacgtagg cgccgcccga cgtgtacggc
    18841 ttggtcgtca tccggccgcc gtcggcgtac tgggacatgc cgacgacgtt gggcaccatc
    18901 acccagtcgt atccgtccac gaagcagcgg tggaaccagt ccgtgaccgc ggcggggtcc
    18961 cagccgcgct gaagtgcgta actgccgagg atcatcagcc gagggatgtg gtgagtccag
    19021 cccgtgtcgc gcacctggga cagcaccgtg cgcaggcacc gcgcctccac cgcgtccgcg
    19081 tccagctcgc tccaccagtg cggcagcgcg gcggtgtggc acaggacgtt ggagcgccgg
    19141 tagtcctcgc cgaagtacca gtagagctgc cacacgtact cgcgccagcc ggcgatctgc
    19201 cggacgaacc cctccacgct gttgagagga gcccggccgg cgcgccactc cgcctctgcg
    19261 cgctcgacgc actcggccgg gtcgagcagg ccgaggttga gcgaggacga cagcaggctg
    19321 tggctcatca ccgggtcggc ggcgagcacg gcgtcctcgt aggggccgaa cgtggggagg
    19381 cggtgggtga ggaagcgttt gagggcggcc cgtgcctcgg cgcgactcgc cgggaacgcg
    19441 cgcggtgcgt cccgtccgac gaaggcgacg tccccgtccc tctcccagcg gtccaggtcg
    19501 tggcggacct cgtcgtcgat gtcgtcctcc cgcggtcgga acggtgcggg aacctggagc
    19561 gtggaggctg cgcgcggtgg gggctgccgg ttgtcgtggt ccaggttcca ccggtcgccg
    19621 gccggggcgt cgccgtccat caggaggtcg tggcccttgc gcacccaccg gtagaagtcc
    19681 tcctgccgca gccgctcgcc gccctgtccg tcggcccacg ccgcgaagtc gtccatcggc
    19741 accaggaagc cccgtgcggg gctcaaggtg acctggggga gtgagcggac cagccgcagt
    19801 gccgcgtacg aggtcgggtg gtggacggtg accggacggt cgccagcgac ctcttccagc
    19861 ccttgccggt aggtgtcggc ccgcacgtag gtcatccgtt cgcccagttc ggccgcccgg
    19921 tggcgcatgg cggagaggat caggtgtgcc ttggcccggt ggaagcggcg gcggcggaac
    19981 accgaacgcg cctcgatcat gagcagcggg gtgtcgcggc cggggccgtc gtcgccgggg
    20041 gtgaggaagt gaggaccgag ctggtcgccg aagagccagt gcacggcgtg tcccttctca
    20101 gtagcgaccg cgggcgtgcg cggggcgcgc cggcccgtcg gagaggtcga gcacaggttg
    20161 ggggtggtcg aggcgggcgc gccgggctcg gggaggaacc ggtccttcac gtgcggttcg
    20221 ggtgcccagc ggcgtacgga ggctccgtgc ggatcgcagc gttcgcgctg gacgaccgga
    20281 ttgaggatcc cgtgtcggcg cggcgcggcg gccggggcgg tcaggcggtc ggtggggaag
    20341 gtgtcgcggc tgggtgcgtc gaagcccgcg gtgtgtacgc cgaggtcgcg gacgtggggg
    20401 ggccacctcc gcgtcggccg ccgtgggcgc ggggcgcggc gtcggacggt cgtgcgggcg
    20461 aagatccgag gtggacagga cgaccgcgcg ggtcatgtcg tcgctcctga gggggtgagg
    20521 cggtgcgagc ggcctagcga cggatgatcc tgacgaaccg ggcgtgcccg gtgcgcggtg
    20581 ctcgtccggg tgcgctcgcc ttcttggcgg cggcctgcgc gatgttgcgg gccataccgc
    20641 cgaagacgac ggagtggaac ggtgcgacgc cccaccaata ggcgtggccg agcagtccgc
    20701 gtggatggaa cagtgtgcgc tggcggtacc gggttcggcc ggcggtgtcc gtttcgacgt
    20761 acatctccag ccaggcgagt ccgggcagtc gcatctcggc acgcagccgc agcagacggc
    20821 ccggctcgat ctcctcgacg cgccagaagt ccagcgggtc accgacccgc aggcgctcgg
    20881 cgtcgcgtcg tccgcggcgc ggaccgactc cgccgacgaa ccggtcgagc catccccgga
    20941 ccgcccaggc gagagggaag gagtaccagc cgttgtcgcc gccgatgcct tcgacgactt
    21001 cccacagcga cgcgcgggac gcgtcgaccg gcaggtgccg gtcgtcctcg tagaggctgc
    21061 cgccggccca gtcggggtcg gtgggcagcg ggtcgctggg ggcgccgggc acggcgtcgg
    21121 acgaccagcg ggtggctacc tggacgtccc gaaccctgcg cagggccagg gcgagggcct
    21181 cgtcgaaggg cagcggccga cccggaggat caggcaggta ccgggcgatg tcgtgttcgt
    21241 ggcacacgac ctcgtggcgc agggattcgg tcagcggccg ggcgatggac gcgggcaccg
    21301 gggtgacgag gccgacccag tggctcgaca gccgcggggt gaggaccggt accggcacga
    21361 tgagccgccg ccgcagtccc gtgatggtgg cgtagcggcg catcatctcc tggtaggtca
    21421 taacgtccgg tccgccgacg tcgaaggccc ggtcgacgtc gggcggcatg gtggccgagc
    21481 cgacgaggta gcgcaggacg tcgtggaccc cgatcggctg ggtccgtgtg tgcacccaac
    21541 tgggggtcac catcacgggc agccgctcgg tgagatagcg cagcatctcg aacgacgccg
    21601 acccggagcc gatgacgatg gccgcccgca gcaccgtggc gggcaccggg ccgtcgagga
    21661 agatgcgccc gacctccgcc ctggagcgca gatgagggga aagggagcgc tcggacaccc
    21721 ctttcggggt gagtccgccg aggtagacga tccgtcgtac tccggcggcg tgcgcctgct
    21781 cggcgaagat ccgggcggcg cggcggtcgg tgtcctcgaa ggtggagccg gttccgagtg
    21841 cgtgcacgag gtagtaggcg acgtcgacac cgcgcatggc cttggcgacg gaggcggcgt
    21901 ccgtgacgtc gccgcggacg gtttcggcgt cctgggtcca gggatggtcg cggagcttgt
    21961 cgggggagcg ggccaggcac cggacccggt gaccggcctg gagcagttca ggcaccagcc
    22021 gtccgccgat gtacccggag gccccggtga ccaggcagcg cagccgttcg ccgttccgct
    22081 gtccatcagt ggctgccacg agtgctcctt ccgcgtgggc ggtccaaccc gctcgtccgt
    22141 ccgatcatgg ctgctgcagt gcgaccgtgc ctgtcgcgcc ctcgtggtcg gcgaccgtga
    22201 cggggaggtg gaggccgttc ggctcggccg ccaccttcag tcggttcccg gcgccggtac
    22261 cggcgccggc aggccgcgcc gagtccggcc acgggggccc gctgtgagtc cgcagtccag
    22321 cagggccagg gccgtccgtc tcccggcctt cagtaccgcg agagcgggca ggccggacgg
    22381 gtgaccgggc gggcggaaga acgggatgcg aggcttgcgt ggaacgcccg ctggcgtccc
    22441 tgcggtgccc gcgccggggg gacctcgggt tcgggccggc acggactgcc gctgccgcgg
    22501 ggtggcggag cgccggcggg acaacagcgc ggtcgcaacg tggatccgac tgctccgcac
    22561 gggcgaaccg catcgtgcac gacccgaggc gaggccacgg gcaccacctg gttcacttcg
    22621 cacgcggcgc cacaccgcgg gatcggactc ggcgaaaggg ccgccctcgg ccgcacccgc
    22681 gttggcgagc accacggacg ccagtccgct cgtcgcgcgg atgtcgtccg cgcgttaccg
    22741 ggcggtgccc ccggtcgtcc gtgacgccga cctccgagca ctcgcggacc gcccgcggcg
    22801 agcgcttgac ccgccggctc cgtccatgag ccaggacagc acttcgacag tggtccggga
    22861 ggtgtccggc cgtcggcgcc gacgtggaat gtgcacgggt tcgggcagca ccgggccttc
    22921 ctcgtgggac gagtacggcg gggtctcagc gccagtcatc gatcacgtag gcgtcggggt
    22981 ggctgtagcc gggttcgttg ggcctgtgca tggccacgcc ctgcaaccag gtgcggaaac
    23041 cgcggtcgac cattcgccgg taggcatcct ggcgggccag gttcgttccg gcgtccagtt
    23101 ggcccaggcc gcgctcggcg gcgagccgct cgcacgcggt gagcagtcgt tcgaaccggt
    23161 cggccgcctc cgggccaggg cgcacggcgc cgaacttgac gaagcacacg tcatctccgg
    23221 cctccgaccc gggtccgcag tggcagacgg ccaggccatc gaggtcggag ccggccccct
    23281 ggagcaggat ggtgtcaccg aggccctgcg cgtgcgtggc cacgatctcg cgttccacgt
    23341 ccaagccctc gaagacggcc ccggtcagcg tgcgacagag gcccagggcg tcgagctgct
    23401 cggcggcggg aagctcgccg tacagcactc ggccggggac cgccgtactg cctgcgacct
    23461 gcttcttcat gatggctgtg aggaatcggg gccagaagcc gtaccggcgg tagagctcga
    23521 ggtgcttcgc actgtgcgag aaggtgaaca ggcccaggtg tcggttcccc caggtctcga
    23581 agcattccat gaccggctcc atgaggcgcc tgccgatgcc ctggtcccac aggtccggat
    23641 gtacggtcag cgggccgaag tacccgacgc tgccccagtc gacggcgaag ttcgacgcaa
    23701 cgacctcgcc ctcgaccgtc gctgcgaagg ccgcatgggg atcggccgcc cagcgagtgc
    23761 gaacgtagtc ggcggtcccg aagaacgtct tcggctcggg agccccgagg aacgtcccga
    23821 aggcgaccct gaagatctcg tcggcccgat ccaggtccgc ctcacccagc gggcggaccg
    23881 acacggggcc cgtgcccctc tggcgctcct ctgccggtgg gatcatcgct ctctccttcc
    23941 cgaccccctg tttcatcgca ccacggacgt gcgccgcagg cgaggcgaaa ggtccaccga
    24001 cagccgggga ccgaggaccg gtccaggaag gtcatctcgt acccgggacg gggagtcggt
    24061 cgacgggccc tgtccgttct ctcgccacca tcgaccccgg tcccgggcgg gcgcctctcc
    24121 aagtgccgaa caatcgccga tccccgaaca ggaccgaccc gcctcagcgt cggcaccaca
    24181 cgtccgagca gcgccaccgg tcgccggccg ctccggtcac gatggcggtc cctccgcgcg
    24241 gtggactctc gctgaccggc gtccgacggc cccctgccca gtggcggcgt tcgtcctgct
    24301 caccgtgagc accggcgacg ccgagggcgt gccggcagct ctcacgtcga cggctgccgc
    24361 ccagcggcgg gtccggtgtc ctcgtgcgcc aggtggctgg gccaccaggc cctgggaccg
    24421 atgtcgagca ccagtgccgg gaccaggagt gaacggacca cgagggtgtc gagcaggaca
    24481 ccgaacgcca cgatgaacgc gatctggacg aggaaggcca gcgggatcac catcagggcc
    24541 gcgaaggtgg cggcgagtac cacgccggcc gaggtgatca ctcctccggt cgtggtcagt
    24601 ccgcgcagca cgccctgccg attgccgtgt gcgagcgcct cctcccgcac ccgggacatg
    24661 aggaagatgt tgtagtccac gccgagggcg accaggaaca cgaagccgta caggggcacg
    24721 gaggcgtccg tgccgctgaa gccgaggagg tgctcgaaga ccagggccga cactccgagc
    24781 gtcgccagga agttgagggc gacggtcgcc accagcagga gcggtacgag cagggagcgc
    24841 agcaacagta cgaggatgat caggatgatg acgagcacga ccggcacgat gagcgtacgg
    24901 tcccgggcag ccgtctgctg ggtgtcgtac tgctgagccg tgtacccgcc gacgagtgcg
    24961 tcggctccgg gcaccgcgtg caggttcgcg cgcaggcgct ccacggtctc cttggcgccg
    25021 tcgctgtccg ccgaggcctc gagggtggcg tcgatgcgga cccgtccatc gaccaccagt
    25081 ggctcgcgtg cccccggccg tcccgacgcg gagaccgcgt cggccgatgc caccccctcg
    25141 gtctccctgg cggctgccgt cacctgggcg gtgcggtcgg cgtcggcgac gatgatggcg
    25201 ggattgccgg agccgccggg gaagtgctcc ccgagcgtct gctgggcggc gaccgagggc
    25261 gcgtcgttga cgaagatctc gtcgagaggc acacccttcg ccgacagcga gggggagaag
    25321 gcggcgaaga cggcgaggcc gagcgcggtc accacccaga tgcgtcgcgg ccgggagtcg
    25381 acgagcgcgg cgacgcgacg ccacacccca tgtccccggt cggacgcgtc cgaagccttc
    25441 ggccgggacg gccagtacgc cgacctaccc agcagggcca gcacggcggg caggaaggtc
    25501 aggctggaga gcgccgcgca cacgatgccg atggcaccga ccggcccgag cgcacggttg
    25561 ttcgtgaggt cgctcgcgag gagagccagc agcgcgaggg ccacggtggc cgcgctcgcg
    25621 gcgatcgcgc cgaacgaccg gcgtacggcg gccagcgcgg ccgatgacgg gtcctcccgc
    25681 aggaccagtt cctcacggaa ccgcgcggcc aggagcagcg cgtagtccgt cgcggcgccg
    25741 atgacgagga tggagaggat gccttgtacc tgcccgtcca cgcggaccac gtcgtgatcg
    25801 gccaggacgt agacgattcc gcacgccaga ccgagagcga acacggaccc gaggatgatc
    25861 aggaacggca gcaggatgct ccggtagacc agcagcagga tcagcagcac ggcggcgagc
    25921 gccactccga gcagcagtcc gtcgatgccc gcgaaggcgt ccgacagatc ggcctgactc
    25981 gccgccgggc cggcgatctg cgcggtggcg cccggcacgc tccgagcggc ctcacgcacc
    26041 tcgctcaaga cgtccggcag tccgtcgccg agatcgggct ccaactggac gaccgcctgc
    26101 aacgccttgc cgtcctcgga gggaagagcg ggcgaggggg cgccgaccac tccggaccgt
    26161 ccggcgaggc cgtcgatcgc acgggtggcc gaggaccgct gcgcttcggt gacgcggccg
    26221 tcgtccgccg tccatacgac gatggcgggc agggtttcgg actggtcgaa cgcctcgcgg
    26281 gccttgagga ccttcgtgga ctccgcgctc tgtggcagga aggcggcctg gtcgttggtg
    26341 gcgacctcgc cgagcttgcc ggcgtacggc ccgagagtgc ctccgactcc gagccaggcg
    26401 acgagcagta cgagcgggac gagccaccgg gcccagcgcg gggtgcttct catggatact
    26461 ccgagcatcc tcgtggtcaa ctaagtcact gacaaagtat cttaatgatt gagtaatctt
    26521 acacttgatc atgcgtggag ccgtcagcgc cacgccacct cttccggaga tcgaccccac
    26581 ggggttgcag tccttggctg tgaatcctga cgtgagtgcc aggagcggaa ccgcacatcg
    26641 acctcgcccg tcgacaccct cgccacggtg tcgagatcgc ttcaggtgcg ccgcggcgag
    26701 gacagccggg tgatcgcgcg gatcaccggt ggcgtcggaa caccttcgcg cccgaggctg
    26761 gaccgcctgc gcggtgaccg cccggcccgg gcgcggtacg cccccgtgtc ggcggcgacg
    26821 acatggaggg ctcggggtgc gggccggaca gttcgggttc caggccgtcg gccagttcgg
    26881 tggtgcggcg gccgatgtca gcgcgccatg cctcgaaggc cccggccgtg agggcgacga
    26941 cgacgagacc gaggagccag ccacccacca cgtcgctgaa ccagtgcacg cccaacgcga
    27001 cgcgggtgaa gccgacaccg agcaccgaga gcactgcgaa acaccagcac cccgcccgcc
    27061 atgcgcgcgg caccatgggc agcaggacca gcagcaggat cgcgaacgac gtggtggccg
    27121 tcatggcgtg gcccgagggg aacgagaagc ccggggcgtg cgccaccggg tcctccaagg
    27181 tgggcctggc ccgctcgacg accaccttga cgagcacccc gatcagcccg ccggccaccg
    27241 ccgtcacggc ggaccaggcg gcgagccgcc acgccccgcg gcgcagcagc cagagggtga
    27301 gcagcgcgac cacgacgcgc agggtcaccg gatcccagac ccagtcggac aggagacgca
    27361 gcgtgccggt ccaagccggg tggtccagcg cggtctcgtt cagtcgccgc gccgcgctcg
    27421 cgtccagtcg gcgcagcggc tgccaccggc cctcgacaag gaccaccagc aggccgaacg
    27481 ccaccgccgc gagcgcggcc acgacggccg cgccgagcag acgcacgccg aacctgtggt
    27541 cggcctcccg gcggcgacgc tcgcgggaac ggcgcgtggt gaaccgtagg ggcattcaga
    27601 ctcccgggtc ggtgcgggtc gggctggtgc gcatggcccg cacggctttc aactgctcgg
    27661 aggcggaaag tccgaggaac agggcgtcgg aggccggatc ggcccggccg ccatcacgat
    27721 gaaccccgcg ccgagcggcg ggccgacgtt gtcggccggt ggatcgccaa ctcggcgaat
    27781 ctgccgatgt cctcggggtg cggggcggtg gacagcccga cgaaggcgat cgccggcggg
    27841 atccccgccg gcaccgtgca gccgtcgacg gcaagccgtg cggctccgta ccgcgtcacc
    27901 gagagcaccg agagcaccga gagcacagtg cgcagggcga gcgcacggga gggcgtgaag
    27961 ccgtcggcgt ggagcaaacg tacgaaggcg tcgcgcggca gcggccggcg gccgtaacgg
    28021 cacagcgcca ccagcgcctc gtcggggcag agttcctcgc cggtcatgtc cttggcctcg
    28081 ggaaactcgg tcgccgtacc catcacccgt ccccggacgg cagcagcatc gtcagcgcgc
    28141 cgggacggac ctccgcggtg aggcgccggc ccggagccac cggatccccg tcgagttcgc
    28201 gcaactgctg ggtctcgaag gtgaactcgg cgcgccggaa ggtgaagaac tccaccggga
    28261 cgccggtacc ggcgtcgtca gcggcgaggg tgtccgcgga cgtgggccgc gctgtcctcg
    28321 cgccgccacg cagtagcgct ccgagagcgc ggatccagcc accgggtccg cgcgggtcga
    28381 ggaccagcag gtcgagccgt ccgtcgtcgg gccgggcggc gggcacgagc gtgacaccgc
    28441 cctgcacgga gc
//
