LOCUS       NZ_CP099468            22613 bp    DNA     linear   CON 04-JUL-2024
DEFINITION  Streptomyces phaeoluteigriseus strain Qhu-M197 chromosome, complete
            genome.
ACCESSION   NZ_CP099468
VERSION     NZ_CP099468.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces phaeoluteigriseus
  ORGANISM  Streptomyces phaeoluteigriseus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
REFERENCE   1  (bases 1 to 9026270)
  AUTHORS   Zhang,B., Xiang,X. and Fan,J.
  TITLE     Complete genome sequence of soil microorganisms Streptomyces sp.
            Qhu-M197 isolated from Alpine meadows habitats on the Tibetan
            Plateau
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9026270)
  AUTHORS   Zhang,B., Xiang,X. and Fan,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-JUN-2022) Faculty of Eco-Environmental Engineering,
            qinghaiuniversity, No. 251 Ningda Road, Chengbei District, Xining
            City, Qinghai Province 810000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: Hifiasm v. v0.14; Circlator v. v1.5.5; Pilon v.
            v1.22
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 68.51291x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023923245.1-RS_2024_07_04
            Annotation Date                   :: 07/04/2024 06:06:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,100
            CDSs (total)                      :: 8,006
            Genes (coding)                    :: 7,707
            CDSs (with protein)               :: 7,707
            Genes (RNA)                       :: 94
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 299
            CDSs (without protein)            :: 299
            Pseudo Genes (ambiguous residues) :: 0 of 299
            Pseudo Genes (frameshifted)       :: 130 of 299
            Pseudo Genes (incomplete)         :: 241 of 299
            Pseudo Genes (internal stop)      :: 34 of 299
            Pseudo Genes (multiple problems)  :: 90 of 299
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:40:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3744456
            Orig. end                         :: 3767069
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP099468.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22613
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="15"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22613
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22613
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12613](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12613)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            113..1033
                     /locus_tag="NFX46_RS16730"
                     /old_locus_tag="NFX46_16730"
     CDS             113..1033
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010981489.1"
                     /locus_tag="NFX46_RS16730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_16730"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_252550141.1"
                     /transl_table=11
                     /translation="MAANSNPTVRRRRLGAELRRLRQASGLKSTEVAERLMVSQPKISH
                     LENGRRAISPRDVRDLCAISGVTDQQVIDALMQMAEESGQQGWWNVYGDVPHSVYIALE
                     TDTATVRAYEPLTIPGLLQTPAYAQAVIGEAMPALTAARAAGRLKVRLRRQHRIYDPTR
                     PLRLWVVLDESVLRRVVGSPDIMREQLEHLNAISAEPHITVQILPYAAGAHPALSGQFS
                     ILSFADTPEAVVHVERFSSDLYLEKPSDVRHFGAMYEHLQAQALSPDDSRDFVTDTVKS
                     YIDAASRPACPAPRSWTPSETLHFE"
     gene            1317..1520
                     /locus_tag="NFX46_RS16735"
                     /old_locus_tag="NFX46_16735"
     CDS             1317..1520
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020119326.1"
                     /locus_tag="NFX46_RS16735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_16735"
                     /product="cold-shock protein"
                     /protein_id="WP_045556499.1"
                     /transl_table=11
                     /translation="MAAGTVKWFNAEKGFGFIEQDGGGPDVFAHYSNIAAQGFRELLEG
                     QKVTFDIAQGQKGPTAENIVPA"
     misc_feature    1700..1714
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.91"
                     /tool="antismash"
     gene            1863..3338
                     /locus_tag="NFX46_RS16740"
                     /old_locus_tag="NFX46_16740"
     CDS             1863..3338
                     /EC_number="3.6.4.-"
                     /GO_function="GO:0004386 - helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1122: ATP-dependent
                     RNA helicase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014145517.1"
                     /locus_tag="NFX46_RS16740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_16740"
                     /product="DEAD/DEAH box helicase"
                     /protein_id="WP_252550143.1"
                     /transl_table=11
                     /translation="MNRMYTNDRPARSRDGRADAGRRGSRFDSQAPRRSGGYGRRPAAL
                     QGEFALPETITPALPAVEGFADLDMPEQLLAELGRQGVTAPFPIQGATLPNSLAGRDVL
                     GRGRTGSGKTLAFGLALLARTAGQRAEPRQPLGLILVPTRELAQQVTDALTPYARSVRL
                     RLATVVGGMSIGKQASALRGGAEVVVATPGRLKDLIDRGDCRLNHVGITVLDEADQMAD
                     MGFMPQVTALLDQVRPEGQRMLFSATLDRNVDLLVRRYLTDPVVHSVDPSAGAVTTMEH
                     HVLHVHGADKHAATTEIAAREGRVIMFLDTKHAVDRLTQDLLNSGVRAAALHGGKSQPQ
                     RTRTLAQFKTGHVTVLVATNVAARGIHVDNLDLVVNVDPPTDHKDYLHRGGRTARAGES
                     GSVVTLVTPSQRRGMARLMSDAGIQPQTTQVRSGDEALNRITGAQAPSGIPVVITAPVT
                     ERPKRSASSRGRRRPASATRRTPVRQSVVGAAA"
     misc_feature    1864..1878
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.9"
                     /tool="antismash"
     gene            3385..3789
                     /locus_tag="NFX46_RS16745"
                     /old_locus_tag="NFX46_16745"
     CDS             3385..3789
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018560467.1"
                     /locus_tag="NFX46_RS16745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_16745"
                     /product="CBS domain-containing protein"
                     /protein_id="WP_252550144.1"
                     /transl_table=11
                     /translation="MTLVQTQPRPADAGPAHGTAVEVMDAAGPQVCDDMSVEVALAVMA
                     AARTSRLVVCDQDGQCTGLVTQAELTAVRDGSAYTDRVRLRDILGDHGSFASPVTTMAE
                     AEHAMRTRRLGALPVVDEQGSALGILALSR"
     gene            3845..4153
                     /locus_tag="NFX46_RS16750"
                     /old_locus_tag="NFX46_16750"
     CDS             3845..4153
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009719283.1"
                     /locus_tag="NFX46_RS16750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_16750"
                     /product="SCO5918 family protein"
                     /protein_id="WP_252550146.1"
                     /transl_table=11
                     /translation="MRCVIARFPFELTKSGVLESMKGVKPEPATGESVIIGRRHYPVKQ
                     VGQVITRQDRRDFSAAEVFRAMARLGFTCRPLPAAAPVDIPDPLQRASAMLGAPVSV"
     misc_feature    complement(4321..4336)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.33"
                     /tool="antismash"
     gene            5305..5901
                     /locus_tag="NFX46_RS16755"
                     /old_locus_tag="NFX46_16755"
     CDS             5305..5901
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037659.1"
                     /locus_tag="NFX46_RS16755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_16755"
                     /product="response regulator transcription factor"
                     /protein_id="WP_289782063.1"
                     /transl_table=11
                     /translation="MVRVLVVHEEELLRSALVQLLRSDDALEVSSMSPRADVPDHDVLP
                     TDVCVVDGECLHGPGEAHDASFRARCGERLVVLTTLRRPGVLRRAFEGGALGLVDKNAP
                     AQRLITAVHTVAKGERFLDAALSVALLEGAVMPLTARELSVLSLAAQGSPMPEIAARLH
                     LSRGTVRNYMATAIRKVGARNRVDAIRIVQNAGWT"
     misc_feature    5434..5436
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5946..7889)
                     /locus_tag="NFX46_RS16760"
                     /old_locus_tag="NFX46_16760"
     CDS             complement(5946..7889)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827682.1"
                     /locus_tag="NFX46_RS16760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_16760"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_252550150.1"
                     /transl_table=11
                     /translation="MSGAGDGRTHHADDGSGALRRIAPPARRFLARRRAVLARLAVWSL
                     AEAGQAFLVGYGVAHSVDQGFLAGDTRKGLSWLAVALVAVLLGAPVIRGVFAELAGLTE
                     PLRDSLVRRAVDRSMAQALDAPGGTDRAAVSRLTNQVEIARDSFAGLVLTLRSFVFTAA
                     GALLGLFSLHPALVVVVLPPLLGGLALFLATLRPMAAAQRRALAADEALGDHAARARAA
                     LRDLTACGTGPETARHGADLVAGAAAASRVLAGWAAVRTAALGVAGHLPVLALLAAVPW
                     LRGRGVTAGALLGAFTYLVQSLLPAVHTLMTALGAAGARLLVVLDRIVGPAPSPTITHG
                     TRPKPPPPAGPPLTPLSVTDVGSTADVGLPAVAPALGGRGSSPAVADLPRPAPTRRSRL
                     PAHGRPTAAVELRSVTLSYGVRAEPVLDSLDLCVAPGEHLAVVGPSGIGKSTLTRLVAG
                     TLAPSGGEIRVAGRSVTGCAVADLAALRVLVPQEAYVFSGTVGDNLAYLRPDAAGADLD
                     ATVRALGLRSLVARLGGLDGSVRPDELSPAERQLIALARAYLSPAPLLLLDEATCHLDP
                     AAEAQAEEALARRPGTLLVVAHRLSSAVRADRVLVLDGVQAVCGKHEEVLARSSLYRDL
                     TGHWNDGSHRKA"
     gene            complement(7886..9661)
                     /locus_tag="NFX46_RS16765"
                     /old_locus_tag="NFX46_16765"
     CDS             complement(7886..9661)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004992230.1"
                     /locus_tag="NFX46_RS16765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_16765"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_252550152.1"
                     /transl_table=11
                     /translation="MVTTEPRAGHVPAAGDGADGTKPGRASELLVLLTSVGAAVAAVAQ
                     PFVLGRTLDLLLRDGDAGHWLTLSAGLLVGEMLLDSLTSLFTGRCNAGWTAAIRSRAFA
                     GLLGAVPERARPYTPGDVGTRLTLNAADAGSGPAARAALAAALITPAGALAALAVVDVW
                     VAACVLAGLPALALLLRTFTRDTGASVAAYQHTQAQIASRLLEALEGTATIAAAGTGAR
                     ERARILAPLTELATLGRRMWALHGRALGRSGVLVPLLILAATAVGGLRLASGALSVGGL
                     LAACRYAQLTAGVGSAASLLGAVVRGREARSRTLALERMPALAYGTRHLPPDGPGDLEL
                     RGVRVVRDGREVLRADGVRIPGGTTAAVVGRSGAGKSLLAAVAGRLTDPDEGQVLLDGV
                     RLDRLTREALRAEVAFAFERPALGEGTVADAIATGLRPVSREQVRQAARAAGADGFVRR
                     LPRGYDTPLPSAPLSGGEYQRLGLARAFGHAGRLLIMDDATSSLDTATEHEVDRALRRS
                     PRPGTRLVVAHRPSVAGRADLVIWLEDGRVRAVASHRDLWNVADYRAVFGVGGNAASTP
                     GERPTQLPEAEGARP"
     gene            complement(9832..9960)
                     /locus_tag="NFX46_RS16770"
                     /old_locus_tag="NFX46_16770"
     CDS             complement(9832..9960)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849360.1"
                     /locus_tag="NFX46_RS16770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_16770"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_006130296.1"
                     /transl_table=11
                     /translation="MNLFDLQSMETPKEEAMGDVETGSRASLLLCGDSSLSVTTCN"
     CDS_motif       complement(9898..9960)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNLFDLQSMETPKEEAMGDVE"
                     /locus_tag="NFX46_RS16770_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9832..9897)
                     /prepeptide="core"
                     /locus_tag="NFX46_RS16770_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="32.20"
                     /molecular_weight="1941.2"
                     /monoisotopic_mass="1940.0"
                     /core_sequence="TGSRASLLLCGDSSLSVTTCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNLFDLQSMETPKEEAMGDVE"
                     /leader_location="[9897:9960](-)"
                     /alternative_weights="1959.2"
                     /alternative_weights="1977.2"
                     /alternative_weights="1995.2"
                     /alternative_weights="2013.2"
                     /alternative_weights="2031.3"
                     /alternative_weights="2049.3"
     misc_feature    9959..9971
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.27"
                     /tool="antismash"
     misc_feature    complement(9990..10006)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.13"
                     /tool="antismash"
     gene            complement(10001..12613)
                     /gene="lanKC"
                     /locus_tag="NFX46_RS16775"
                     /old_locus_tag="NFX46_16775"
     CDS             complement(10001..12613)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972314.1"
                     /locus_tag="NFX46_RS16775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_16775"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_252550154.1"
                     /sec_met_domain="micKC (E-value: 8.6e-242, bitscore: 803.6,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 3.9e-12, bitscore: 44.9,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 9.7e-11, bitscore:
                     39.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKGYAVYCDADPHFYDAPHRTVVRNGSGRSRYAAASLPVPAGWQ
                     RNESGDWLALRPVDADLPDQGWKIHVSACLDNAESVLERVWRYCVAGGTAFKFVPSRYL
                     LHQRNAKYADRAGSGKFITVYPSDEARFEQITGELSALLAGEPGPHILSDLRIGDGPVH
                     VRYGGFTRRNCYDASGELRPAVTGPDGVLVPDLRGPVFRVPDWVSVPTFLRPHLDARSA
                     VTVADLPYTIDSALHFSNGGGVYLARDTRTGEQVVLKEARPHAGLAADGADAVTRLHRE
                     RRALERLSGLDCTPEVLDHLTVGEHHFLVLEYIDGKPLNTFFARRHPLIEADPGEQRLA
                     EYTAWALDVHARVERAVEEVHARGVVFNDLHLFNIMLREDGSVTLLDFEAAHQIDEPGR
                     QTVANPGFVAPSDRRGVAVDRYALACLRLALFLPLTSLLALDRRKAAHLADVVASQFPV
                     DRAFLDAAVDEITDVPRTVGVPAARVTAEPLVPVRPGDWPLSRESMAAAIHASATPSRT
                     DRLFPGDIAQFATAGGGLAFGHGAAGVLYALAESGAERSEDGEQWLLERTKQAPSGMPL
                     GFHDGLAGIAWTLEYLGHRDRALDLADLLLEQSFDHLAPDLHSGTAGLGLALDSLAATT
                     GEAALRSAALRCVELTARGAQAGSGDARPRAGLLHGAAGSALLFLRLYERTGDSALLDL
                     AGDALRRDLARCVRGAGGALQVDEGWRTMPYLGAGSVGIGMVIDDYLAHRDDDEFARAR
                     NEIVAAAQAMFYAQPGLYRGVSGMVLYLGRTTATGHGTGPEALRRQIDALSWHAMSYRG
                     RLAFPGEQMMRLSMDLSTGTAGCLLAVASVHGDPPAGLPFLPPPPTGQRPLTRPHQGS"
     misc_feature    12645..12657
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.13"
                     /tool="antismash"
     misc_feature    complement(12705..12722)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.66"
                     /tool="antismash"
     gene            13077..14711
                     /locus_tag="NFX46_RS16780"
                     /old_locus_tag="NFX46_16780"
     CDS             13077..14711
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (95-251). E-value:
                     5.9e-23. Score: 73.7. Matches aSDomain:
                     nrpspksdomains_NFX46_RS16780_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006374168.1"
                     /locus_tag="NFX46_RS16780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_16780"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_252550156.1"
                     /sec_met_domain="PF00561 (E-value: 4.3e-26, bitscore: 90.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPQGIPRRFGRLTAVGAALTAFMVAVTGTAIQAAASPKTTEKP
                     PVPSLTWTDCQGGFECANADVPLDYRKPQGKTITLAVVRKKAADQTKRKGTLFMQPGGP
                     GNSGVDFVRNNHATLPAALRDSFDVFGYDVRGVGRSSALTCFDDARYTRAVTEAKGVPG
                     PDAFEPALREAAAFDQACVDNAGELLPHVGTEYVARDIDLLREALGEQQLTYYGRSFGS
                     YIGTVYAAMFPKRVRALTLDGAYDPVHYANRPYAYDRPQYLALDGAMSRFLDWCAADQS
                     TCGFGDGNPRAAFEKLKADLDANPVPTANGGQANGYTLVYRLMFNINEGKVIWPTLGAQ
                     LRKAQLRDNTSFLLRPPSPASFDFLGPNVAVECVDRDYPRDLRRLERNVAANAKAAPLL
                     GPAMAYGPPTYDHQHATACVQWPGERVSRYDGSYRAKGSAPILVLGTTGDPDTPYRDAV
                     ALSRRLDNASLLTFRAEGHTAFGRSACATDAVVAYLVDLEVPASGTTCADETQPPSSTP
                     KAAPPGTTLGELRNGVDERVERIGAVS"
     aSDomain        13362..13829
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NFX46_RS16780_Abhydrolase_1.1"
                     /evalue="5.90E-23"
                     /label="NFX46_RS16780_Abhydrolase_1.1"
                     /locus_tag="NFX46_RS16780"
                     /protein_end="251"
                     /protein_start="95"
                     /score="73.7"
                     /tool="antismash"
                     /translation="TLFMQPGGPGNSGVDFVRNNHATLPAALRDSFDVFGYDVRGVGRS
                     SALTCFDDARYTRAVTEAKGVPGPDAFEPALREAAAFDQACVDNAGELLPHVGTEYVAR
                     DIDLLREALGEQQLTYYGRSFGSYIGTVYAAMFPKRVRALTLDGAYDPVHYA"
     gene            15138..15629
                     /locus_tag="NFX46_RS16785"
                     /old_locus_tag="NFX46_16785"
     CDS             15138..15629
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105900.1"
                     /locus_tag="NFX46_RS16785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_16785"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_252556521.1"
                     /transl_table=11
                     /translation="MTGDEVLEILEALRGSGSDVWIGGGWGIDALLGRQTRPHRDLDLM
                     HRQEQEPTVVAALSQAGFVESLDWRPARFVVTDATGREIDLHPLVFAPDGSATQASLEP
                     GRPFVYPAACFVTGTIRHSTVPCLSAEQQVYFHQGYEPTDRDRQDMARLREAFGISTHF
                     "
     gene            complement(15901..16740)
                     /locus_tag="NFX46_RS16790"
                     /old_locus_tag="NFX46_16790"
     CDS             complement(15901..16740)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018844866.1"
                     /locus_tag="NFX46_RS16790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_16790"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_252550158.1"
                     /transl_table=11
                     /translation="MPTTPLGDYLRARRALVRPESAGIPAGGARRVPGLRREEVAMLAE
                     MSVDYYTRLEQGRERGPSAQVLDALSRVLRLDDDARLHLYRVAGLTPGQRSSGAAERVD
                     PQLRSLMEMWPATPAIVLGRAYDVLAVNPLADALFDGFRQGPNLMLKVFLDPDAHRLYP
                     DWESVAVNAVAGFRMLHGDDPHDPRLHEVLRTLTERSPEFVRLWKRHDARRKRLRSKRF
                     HHPDVGELTLRVQVFDVRSAPGQELVVHHAEAGSPSAEALALLGTLAATRARENRAG"
     gene            16923..17702
                     /locus_tag="NFX46_RS16795"
                     /old_locus_tag="NFX46_16795"
     CDS             16923..17702
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (22-190). E-value: 6.9e-15.
                     Score: 47.4. Matches aSDomain:
                     nrpspksdomains_NFX46_RS16795_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014175316.1"
                     /locus_tag="NFX46_RS16795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_16795"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_252550160.1"
                     /sec_met_domain="adh_short (E-value: 1.3e-32, bitscore:
                     112.1, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTENNANTGPVHTESLAPDTSKVVLVTGAASGIGRATACRLARDG
                     HHVVLTGRRTDLLKETADLLTEEGSRAEARYLDVTDRTGYADLVDDVLAEQDRIDVLVG
                     NAGVMLLSRLESVLTDEWDRMLDVNVRGLYHGIAAVLPHFRARGTGHFVTVASIGAHQV
                     VPTSAVYSATKYAAWALTEGLRQESVPGIRVTTVSPGVVESELAEHITDPYAAEAMRTY
                     RAAAIPADAVADAIAFAISRPDDVDVNEIVVRPAAQR"
     CDS_motif       16989..17084
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NFX46_RS16795_0001"
                     /evalue="1.40E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="NFX46_RS16795"
                     /protein_end="54"
                     /protein_start="22"
                     /score="20.9"
                     /tool="antismash"
                     /translation="VVLVTGAASGIGRATACRLARDGHHVVLTGRR"
     aSDomain        16989..17492
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NFX46_RS16795_PKS_KR.1"
                     /evalue="6.90E-15"
                     /label="NFX46_RS16795_PKS_KR.1"
                     /locus_tag="NFX46_RS16795"
                     /protein_end="190"
                     /protein_start="22"
                     /score="47.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVLVTGAASGIGRATACRLARDGHHVVLTGRRTDLLKETADLLTE
                     EGSRAEARYLDVTDRTGYADLVDDVLAEQDRIDVLVGNAGVMLLSRLESVLTDEWDRML
                     DVNVRGLYHGIAAVLPHFRARGTGHFVTVASIGAHQVVPTSAVYSATKYAAWALTEGLR
                     QESVP"
     gene            18018..18380
                     /locus_tag="NFX46_RS16800"
                     /old_locus_tag="NFX46_16800"
     CDS             18018..18380
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656045.1"
                     /locus_tag="NFX46_RS16800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_16800"
                     /product="hypothetical protein"
                     /protein_id="WP_252550162.1"
                     /transl_table=11
                     /translation="MQEWTYSPTAVTVPQLMLDPYRCGFDAHTALGEAETQGQWGDEDW
                     RVPPQARTEEEAPWSAPDPGPRPPLAPADRRRLELHAALVRAGVAPAPGDLHAVTVLST
                     LDDTVNDAVRRWIAAY"
     gene            complement(<18714..19142)
                     /locus_tag="NFX46_RS16805"
                     /old_locus_tag="NFX46_16805"
                     /pseudo=""
     CDS             complement(<18714..19142)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645659.1"
                     /locus_tag="NFX46_RS16805"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_16805"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="METADSRQRAAPGAVTAFARFVLLGGGVGLTSGFAVAALASCIPW
                     VLANALITVASTFLATELHARFTFGAGRPATRRQHAQSAGSAAAAYSVTCAAMLALQQL
                     VATPSAMLEQAVYLSASALAGIARFAVLRLAVFTRGRPQ"
     misc_feature    19364..19375
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 21.4"
                     /tool="antismash"
     misc_feature    complement(19594..19608)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.07"
                     /tool="antismash"
     gene            19991..21301
                     /locus_tag="NFX46_RS16810"
                     /old_locus_tag="NFX46_16810"
     CDS             19991..21301
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015655339.1"
                     /locus_tag="NFX46_RS16810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_16810"
                     /product="MFS transporter"
                     /protein_id="WP_353850167.1"
                     /transl_table=11
                     /translation="MPPASCAASASGRPVPSRLWRDGDFRRLWVGQTVSQLGEHTTLVV
                     LPLFAVLTLDAGAGQLGVLRAVGQAPILLLSLFVGAWVDRWRARTVMVLTDVGRALALG
                     AAAVAGLLGWLGLPALFVVAFAVGALSVFFDVAYQASLVRLVKRDQLVERNSALEGSRS
                     AAQIGGPALGGALVSLLSAPVAAASSALFFALSFLSIRRIRRSEALPKGPERPPRVWRR
                     IHEGLRFVVGDASLRTVCLASAAFQFSLAAVMTVYLLFLPRELHLSGTAVGLALAATGP
                     GALLGSVLAARLPRRFGHGAVLVSAAVLGDGVFLCVPALHGSSAVTLAALLAVNFVFGT
                     GGQLVNVTVMAVRQAVTPDGMQGRAAATITFVGMGLTPLGSLLGGLLAEEWGLRTSLLV
                     TAAGMLLSPLLMALSPLARLGRALPSPAGPATEPRTP"
     gene            21659..22396
                     /locus_tag="NFX46_RS16815"
                     /old_locus_tag="NFX46_16815"
     CDS             21659..22396
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670452.1"
                     /locus_tag="NFX46_RS16815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_16815"
                     /product="VOC family protein"
                     /protein_id="WP_252550163.1"
                     /transl_table=11
                     /translation="MTLRPVQVNIKARDDSAVGRFWAEALGWRVSSSGPGATAVQPVGF
                     DWLDPVTVCVDVIAVPESKTTTKNRVHLDLATTSAAHQAELVERLRALGATPAHVGQGD
                     VPWTVLADPEGNEFCVLEPREIYRDTGPIARIVVDCAVPPDMARFWDEAMDWTLCEVTD
                     DRAVWRSAQGVGPYLEFLRTGVKTVPDRVHLDLVPEPGDDKAAEVARLRALGATDLDLG
                     QGDVPWTCLTDPEGHEFCVLARS"
ORIGIN
        1 gcttccgata cgcgcggaca tggcggcatg gcgcttgatc gacaagcctg ccgtcgtggc
       61 aaccttcgcg cgagagcagt gacttggaat cggatccgga ggtataccgc ccgtggcggc
      121 gaacagcaat cccaccgtca ggagacggcg tctgggagcg gagctccgtc ggctccgtca
      181 ggccagtggg ctgaagagca cggaggtggc cgagcgactc atggtctccc agcccaagat
      241 cagccacctg gagaacggcc gccgcgccat cagcccccgc gacgtacgtg atctgtgcgc
      301 gatctctgga gtgacggacc agcaggtcat cgacgcactg atgcagatgg cggaggaatc
      361 cggacagcag ggctggtgga acgtctacgg cgacgttccc cacagcgtct acatcgcgct
      421 ggagacggat accgccaccg tccgtgccta tgagcccctg acgatccccg gcctgttgca
      481 gaccccggcc tacgcccagg cggtgatcgg agaagcaatg cctgcgctca ccgccgcgcg
      541 ggccgccggc cgcctcaagg tgcggctccg ccgtcagcac cggatctacg acccgacccg
      601 cccgctgcgt ctgtgggtcg tcctggacga atcggtactg cgccgcgtcg tcggcagtcc
      661 cgacatcatg cgcgaacagc tggagcacct gaacgcgatc agtgctgagc cccacatcac
      721 tgtccagatc ctcccctacg ccgcgggggc ccaccccgcc ctctcggggc agttctccat
      781 cctgagcttc gccgacaccc ccgaggccgt ggtgcacgtg gagcgcttct ccagtgatct
      841 ctacctggag aagccgtccg acgtgcggca cttcggcgcg atgtacgagc acctccaggc
      901 ccaggcgctc tcccctgacg acagccgcga cttcgtcacc gacacggtca agtcgtacat
      961 cgacgcggcg agtcgaccgg cctgccccgc acccaggtcc tggacgccct ctgaaacgct
     1021 gcacttcgag tgaagcaata tctacgctcg tgaggtgaga gttttacgga ccatgcggtg
     1081 agagattttg tcgcgatggg cggagcggaa ttcttcgacg cgcgcaggcc gttccggcgt
     1141 gctactgtct tcctcagttg cagttgtggt tcccaaaact tcaagtgccc tcacccggtt
     1201 ccttcgggtg ggagcacttt tgtatgccgg ttatttttcc gggcggggta atcatcgcgg
     1261 cgacacggcg tccgcgcagt gcggattccg atgtattgcc ccaaaggaga tatgacatgg
     1321 ctgctggtac cgtgaagtgg ttcaacgcgg aaaagggctt cggcttcatc gagcaggacg
     1381 gtggcggccc ggacgtgttc gcccactact cgaacattgc cgcgcagggc ttccgtgagc
     1441 tgctcgaggg ccagaaggtg accttcgaca tcgcgcaggg ccagaagggc ccgacggccg
     1501 agaacatcgt tccggcctga cgctgacgca cactctgtag ctggggcccg catccttcgg
     1561 ggtgcgggcc ccagctgcac gcgtatcccg cagcggtcgc gtccgtggga cggctcggag
     1621 gaatccgtgg tcccacccca gcgactcctc ccttcgggga tgcgggtgca ttcgaaaagc
     1681 tgcaccgcgg tcggcgcccg gactttacgt cccatcgcgc cacgcatttc agcacctcgg
     1741 cccgcgtgaa tatccgccgg ccgaaattgc tctcttttgt catcggtcca tacctgtgat
     1801 tctccatgcc gctcatcgct gcgggaattc cttgatatgc gccgcatcga ggaaggttcc
     1861 gcatgaaccg catgtacacc aacgaccgcc ccgcccgctc ccgtgacggc cgtgccgacg
     1921 ccggcaggcg cggcagccgc ttcgactcgc aggcgccccg ccgctccggc ggttacggcc
     1981 gtcggcccgc cgcactgcag ggtgagttcg cgctccccga gacgatcacc cccgcgctgc
     2041 ccgccgtcga gggcttcgcc gatctcgaca tgcccgagca gctgctggcc gaactcggca
     2101 ggcagggtgt gacagcaccg ttcccgatcc agggcgcgac gctgccgaac tccctggccg
     2161 gccgtgacgt gctgggccgc gggcgcaccg ggtccggcaa gaccctggcc ttcggcctcg
     2221 ccctgctcgc ccgcaccgcc ggacagcgcg ccgagccccg ccagccgctg gggctgatcc
     2281 tcgtacccac gcgtgagctg gcgcagcagg tgaccgacgc gctgaccccg tatgcccgct
     2341 ccgtgcggct gcggctggcc acggtcgtgg gcgggatgtc gatcggcaag caggccagtg
     2401 cgctgcgcgg cggggccgag gtcgtcgtcg cgacgcctgg gcggctcaag gacctcatcg
     2461 accgtggcga ctgccggctg aaccacgtgg gcatcacggt gctggacgag gccgaccaga
     2521 tggccgacat gggcttcatg ccccaggtca ccgcgctgct cgaccaggtg cgtccggagg
     2581 ggcagcggat gctgttctcc gccaccctgg accgtaatgt cgacctgctc gtgcgccgct
     2641 acctgaccga ccccgtcgtg cactcggtcg acccgtcggc cggtgcggtc acgacgatgg
     2701 agcaccacgt cctgcacgtc cacggcgccg acaagcacgc cgccacgacc gagatcgccg
     2761 cccgcgaagg ccgcgtgatc atgttcctgg acaccaagca cgccgtcgac cggctcaccc
     2821 aggacctgct caacagcggg gtgcgggccg ccgcgctgca cggcggcaag tcgcagccgc
     2881 aacggacccg cacgctggcg cagttcaaga cggggcacgt caccgtactg gtggccacca
     2941 acgtcgccgc gcgcggcatc cacgtcgaca acctcgacct cgtcgtcaac gtcgacccgc
     3001 cgaccgacca caaggactac ctccaccgcg gcggccgtac cgcccgcgcc ggcgagtccg
     3061 gcagtgtcgt caccctcgtc acccccagcc agcgtcgtgg catggcccgc ctcatgtcgg
     3121 acgcggggat ccagccgcag accacccagg tccgctccgg cgacgaggcc ctgaaccgga
     3181 tcaccggcgc ccaggctccc tccggcatcc cggtcgtcat caccgcaccg gtgaccgagc
     3241 gtcccaagcg cagcgcctcc tcccggggcc gccgccgccc cgcctccgcg acccggcgca
     3301 cccccgtacg ccagtccgtc gtcggcgcgg cggcctagaa ccttcgtgct ccggaagccg
     3361 gtccatctct gcaggaggca ccttttgacg ctggttcaga cgcagccccg cccggcggac
     3421 gccggccccg cgcacgggac ggcggtggag gtcatggacg cggccggacc gcaggtgtgt
     3481 gacgacatga gcgttgaggt ggcgctggcc gtcatggccg ccgcccgcac aagccgactg
     3541 gtcgtctgcg accaggacgg ccagtgcacc ggcctggtca cccaggccga actcaccgcc
     3601 gtgcgtgacg gctccgccta cacggaccgt gtccgcctgc gcgacatcct cggcgaccat
     3661 ggctcgttcg cctcacccgt gaccacgatg gccgaagccg agcacgcgat gcgcacccgt
     3721 cggctcggtg ccctgccggt ggtcgacgag caaggcagcg ccctgggcat cctcgccctc
     3781 tcccgctgaa ccgtctcacc tctggtctgg tcggaccgtt ctccccttct ctctgtgagg
     3841 ccccatgcgc tgcgtcatcg cccgcttccc cttcgaactc accaagagcg gtgtgctgga
     3901 atcgatgaag ggcgtcaagc ccgaaccggc caccggcgaa tccgtcatca tcggccgccg
     3961 ccactacccc gtgaagcagg tggggcaggt catcacccgc caggaccgcc gtgacttcag
     4021 cgccgccgaa gtcttccggg ccatggctcg gctcggcttc acctgccgcc cccttcccgc
     4081 ggccgcaccc gtggacatcc ccgacccgct ccagcgagct tccgcgatgc tgggcgctcc
     4141 cgtatccgtc tgacgcaggg aacgggcccg agccgatggg ccgccggcag cggcccgtga
     4201 cacgatcacg gccttcgtcg acgagcacac catcacgaca ccggccgagg ggcgtggtgt
     4261 ccccggtgac gtcgcacggg agttgacggg gctgccgcgg ccttgggtgc ttctggtgaa
     4321 gtaagaagaa cctgaacgat cacgaggccc gggcctacga gccacgtccg ctccgcccgg
     4381 tgcccgggcc gaccatgggc cacgactggc acggcgctcc cgcgacggcg gcgttcgcgc
     4441 acggcagcac ggaccacgcc gaggtggtgg accactctcg tggaggcggt cctcaaccac
     4501 ctccacgatg aagcctcgcc ccactcatgg cgcggattcg gcggcttctg cgaccaagtg
     4561 gcagaggcgc ccggcaggga cgggctggtg cctcttgccc agacagccga aacggcgtcg
     4621 accacgaccc gttccccctg aagctgatcg tggccacccg cgaggacatc accgcccgga
     4681 actgcgacag cctccatttc gagcagcagt actgacctgc cgctgggatc cgcacacgtg
     4741 tgccggcgga aaccccgtcc cgccacccct cgcggagccg gacggctcca ccaccttgtg
     4801 cgaatctccc gccgcgtccg ccccgacctg ggcgaacgcg gcggtagagg gccggcctgc
     4861 ggggaggtcc cgcccgcgca agagcgcgga ccgcgagggc ggcgggttcg cgccagattg
     4921 gaagacggct gttttcggcc ggtccccgcg cggtctcaag ccgctgcctg atacatccgg
     4981 ttcggcggca tacggccgat ccgagggcga cccgccgccg tggccaggga gccggggacg
     5041 gcgggacggg cgcgacggcc gtccgtccga tcggccgtgt gtcgatcccg gccgacggtt
     5101 ggcgtgtgtc tccgccgttt tcgcccgcgt ggtgatcggc ctttcgccta cttccgggcg
     5161 ctggaagcgg cgcattgatt ccggtgcgcc gtcaccctgc tggtgagccg tgttcccccg
     5221 ggacggatca gggcacatgg ccctggtgcg cgaggagcgt agtcggctgc ccttcgaaac
     5281 agccgctgac aaggggtggg ggagatggtt cgggttctcg tggtgcacga agaggaactg
     5341 ctgcgttcgg cattggtgca actgctcaga tccgacgacg cgttggaggt ctcgtccatg
     5401 tctccccgcg ccgacgtccc cgatcacgac gtgttaccga cggacgtgtg cgtcgtggac
     5461 ggcgagtgtc tgcacgggcc gggggaagcg cacgacgcgt cgttccgggc gcggtgcgga
     5521 gagcggctcg tcgtcctgac caccctccgg cgtccgggcg tactccgcag ggcgttcgag
     5581 ggcggtgcgc tcgggctggt cgacaagaac gccccggccc agcgactgat cacggcggtg
     5641 cacacggtgg ccaaaggtga gcgcttcctc gacgcggccc tgagcgtggc cctgctcgaa
     5701 ggtgcggtca tgcccctcac cgcacgcgag ctgagcgtgc tgtccctggc cgcccagggg
     5761 tcgccgatgc ccgagatcgc ggcccgtctg catctgtccc gggggaccgt ccgcaactac
     5821 atggccacgg cgatccgcaa agtgggcgcc cgtaaccggg tcgacgcgat acgcatcgtc
     5881 cagaacgccg gctggacgtg acgaaccgtc cggtgcggtg accgtgcccg cacggcgtac
     5941 cgcgttcagg cctttcggtg ggaaccgtcg ttccagtggc cagtcaggtc acggtagagc
     6001 gacgaacggg ccagcacctc ctcgtgcttg ccgcacaccg cctgcacgcc gtccagtacc
     6061 agcacccggt cggcccggac ggccgacgac aggcgatgcg ccacgaccag cagcgtcccc
     6121 ggccgccgtg cgagagcctc ctccgcctgt gcctcggcgg ccgggtccag gtgacacgtg
     6181 gcctcgtcga gcagcagcag gggtgcgggt gacagatacg cgcgcgccag ggcgatcaac
     6241 tgtcgttcag ccggggacag ttcgtcgggt cgcacggagc cgtcgagccc gcccagacga
     6301 gcgaccagcg accgcaggcc gagggcccgg acggttgcgt cgagatccgc cccggccgcg
     6361 tccggacgca gatacgcgag gttgtcgccc acggtgccgg agaagacgta cgcctcctgc
     6421 gggaccagca cacgcagtgc ggcgaggtcg gcgacagcgc acccggtcac cgagcgtccg
     6481 gccacgcgta tctcgccgcc gctgggcgcg agcgtccccg cgaccaggcg ggtgagcgtc
     6541 gatttcccga tgccgctcgg tccgacgacc gcgaggtgct cacccggggc gacgcacagg
     6601 tccagcgagt cgaggaccgg ctcggcgcgc acgccgtagg acagggtcac ggaccgaagc
     6661 tccaccgccg cggtcggccg tccgtgcgca gggagccgcg agcgtcgggt cggggcgggg
     6721 cgcggcaggt ccgccaccgc cggggacgag ccgcggcccc cgagggccgg tgccaccgcc
     6781 gggaggccga cgtcagccgt tgatccgacg tcggtcacgc tgaggggggt caggggcggg
     6841 cccgccgggg gcgggggctt gggtcgcgtg ccgtgcgtga tcgtcggtga tggcgcgggg
     6901 ccgacgatcc ggtccaggac gaccagtagc cgggcccccg ccgcgccgag cgcggtcatc
     6961 agtgtgtgca cggccggtag cagcgactgg acgaggtagg tgaaagcgcc caacagcgcg
     7021 cccgctgtca cgccccgtcc gcgtagccac ggcaccgccg ccagcagggc cagcacgggc
     7081 aggtgacccg cgacaccgag cgccgccgtg cgcaccgccg cccagccggc caggacacgg
     7141 gacgccgcgg cggcacccgc gaccaggtcc gcgccgtgtc gcgccgtctc ggggccggtc
     7201 ccgcaggccg tgagatcacg caacgcggcc cgggcccggg ccgcgtggtc gcccagcgcc
     7261 tcatcggccg ccagcgcgcg tcgttgggcc gccgccatgg gccgtagcgt ggccaggaac
     7321 agcgccaggc ccccgagcag cggcggcaga accaccacga ccagggccgg gtgcaaggag
     7381 aacagtccga ggagcgctcc ggcggcggtg aagacgaacg aacgcagggt gagaaccaga
     7441 ccggcgaagc tgtcccgggc gatctcgacc tggttcgtca gccgggagac ggccgcccgg
     7501 tccgtgccgc cgggcgcgtc gagggcctgg gccatggacc ggtcgacggc acgccgcacg
     7561 aggctgtcgc gcagcggctc cgtcagccct gccaactcgg cgaagacacc ccggatcacc
     7621 ggagcgccga gcagcaccgc gaccagggcg accgcgagcc acgacagccc cttgcgtgtg
     7681 tcaccggcga gaaacccctg gtcgacggag tgggcgacgc cgtagcccac gaggaaggcc
     7741 tgccccgcct ccgccagcga ccagaccgcg agccgcgcca gcaccgcccg gcggcgcgcc
     7801 aggaagcgac gggcgggcgg cgcgatccgg cgcagtgccc cggagccgtc gtccgcgtgg
     7861 tgcgtacggc cgtcaccggc gccgctcacg ggcgtgctcc ttcggcttcg ggcagttgcg
     7921 tgggcctctc gcccggcgtc gaggccgcgt tgccgccgac gccgaagacc gcccggtagt
     7981 cggccacgtt ccacaggtcg cggtgcgacg cgacggcccg cacccttccg tcctccagcc
     8041 agatcaccag gtcagcccgg cccgcgaccg acggccggtg ggcgacgacc agccgggtcc
     8101 cggggcgcgg cgatcggcgc agcgcccggt ccacctcgtg ctccgtggcc gtgtccaggc
     8161 tggacgtcgc gtcgtccatg atcagcagtc gtccggcgtg cccgaacgcc cgtgccagcc
     8221 cgaggcgctg gtactcgccg cccgaaagcg gtgccgaggg cagcggggtg tcgtaaccgc
     8281 gtggcagccg gcgtacgaag ccgtcggcgc ccgcggcgcg ggcggcctgg cgtacctgct
     8341 cgcgcgagac cggccgcagt ccggtggcga tcgcatcggc gaccgtcccc tcacccagcg
     8401 ccggacgctc gaaggcgaag gcgacctcgg cgcgcaacgc ctcgcgggtc aggcggtcga
     8461 ggcggacccc gtcgagcagc acctgtccct cgtcggggtc ggtcagccgc cctgccacgg
     8521 ccgccaggag ggacttcccc gccccgctgc ggccgaccac cgcggcggtg gtgccgcccg
     8581 gtatccgcac gccgtcggcg cgcagcactt ccctgccgtc gcgtaccacc cgcacaccgc
     8641 gcagttcgag gtcgcccggg ccgtccggcg gcaggtgccg cgtcccgtag gccagcgcgg
     8701 gcatccgttc cagcgccagg gtccggctcc gcgcctcacg accccgtacg accgcgccca
     8761 gcagtgacgc ggcactgccg acgccggccg tcagctgtgc gtagcggcag gcggcgagca
     8821 ggccgcccac gctcagggca cccgacgcca ggcgcagacc tccgacggcc gtggctgcca
     8881 ggatcagcag cggcacgagg acgccgctcc ggcccagcgc ccgtccgtgc agtgcccaca
     8941 tgcgccggcc cagggtcgcc agctccgtca acggtgcgag gatgcgcgcg cgttcacggg
     9001 cgccggtccc cgcggcggcg atcgtcgccg tgccctccag agcctccagc agccgggacg
     9061 cgatctgcgc ctgggtgtgc tggtaggcgg ccaccgacgc accggtgtcg cgggtgaacg
     9121 tccgcagcag cagcgccagg gcgggcagcc ccgccagcac acacgccgcc acccacacgt
     9181 cgacgacggc cagcgcggcg agtgcgcccg ccggggtgat cagcgcggcc gccagagccg
     9241 cccgggccgc cgggccgctg cccgcgtcgg cggcgttgag ggtcaggcgg gtcccgacgt
     9301 cccccggggt gtaggggcgc gcgcgttccg gtacggcgcc cagcagtccg gcgaaggcgc
     9361 gggagcggat ggcagccgtc caaccggcgt tgcagcggcc ggtgaacagc gaggtgaggc
     9421 tgtcgagcag catctcgccg acgagcaggc cggcgctgag cgtcagccag tgtcccgcgt
     9481 caccgtcgcg cagcaggaga tcgagggtgc ggccgagcac gaagggctgg gccaccgcgg
     9541 ccaccgccgc cccgaccgag gtcagcagca ccagcagttc cgacgcacgc cccggcttcg
     9601 tgccgtcggc tccgtcaccc gcggcgggca cgtgccctgc ccgcggctcg gtcgtcacca
     9661 ccccacgaac ccccttcgat ccgccccacg tgccaggaca ccggtcgcgc acccggtggg
     9721 gtacgtggca caggtgtccg cgaacgcagg caccggtgcc ccgggcatgg cccggggcac
     9781 cggtgccgag cagcgttgat caccgcgtcg ccgcggtggt cggctcgggc gtcagttaca
     9841 ggtcgtgacg ctgaggctgc tgtcgccgca gagcagaagg ctcgcgcggc tgccggtctc
     9901 gacgtccccc atggcctctt ccttcggggt ttccatcgac tgcaggtcaa acaggttcat
     9961 gacattgtcc cttcgtgtgg caacgggttc tgttctttca tcacgacccc tggtggggcc
    10021 gagtcagggg ccgctgcccg gtgggcggcg gcggaaggaa cggcagcccg gcgggcgggt
    10081 cgccgtggac ggaggcgacg gccagcaggc atccggccgt tcccgtggaa aggtccatgg
    10141 acaggcgcat catctgctca cccgggaagg ccagccggcc gcgataggac atggcgtgcc
    10201 aggacagcgc gtcgatctgg cgccggaggg cctcgggccc ggtgccatgt cccgtggccg
    10261 tggtgcggcc gagatacagc accatcccgg acacgccccg gtagagaccc ggctgggcgt
    10321 agaacatggc ctgggcggct gccacgatct cgttcctcgc ccgcgcgaac tcgtcgtcgt
    10381 cccggtgcgc caggtagtcg tcgatgacca tgccgatgcc cacgctgccc gcacccaggt
    10441 agggcatggt gcgccacccc tcgtcgacct gcagcgcgcc gcccgcgccc cggacgcaac
    10501 gggccaggtc ccggcggagc gcgtcgcccg cgagatcgag cagcgcggag tccccggtgc
    10561 gttcgtagag ccggaggaag agcagagcgc tgcccgccgc gccgtgcagc aggcccgcgc
    10621 ggggccgggc gtccccgctc ccggcctgcg cgccgcgagc ggtcagctcg acgcagcgca
    10681 gggccgccga gcgcagcgcc gcctctccgg tggtggcggc cagcgagtcc agggcgaggc
    10741 ccagccccgc ggtgccgctg tgcaggtcag gggccaggtg gtcgaacgac tgctcgagga
    10801 gcaggtcggc caggtcgagg gcgcggtcgc gatggccgag gtactccagt gtccaggcga
    10861 tcccggcgag cccgtcgtgg aagccgagcg gcatgcccga cggtgcttgc ttggtccgct
    10921 ccaggagcca ctgttccccg tcctcactgc gttccgcgcc gctctcggcg agggcgtaca
    10981 gcacccccgc cgcgccgtgg ccgaaggcca gcccgccgcc cgccgtggcg aactgcgcga
    11041 tgtcgccggg gaagagacgg tcggtgcggg acggcgtcgc ggacgcgtgg atcgccgcgg
    11101 ccatcgactc ccggctgagc ggccagtcgc cgggccggac cggcaccagc ggttcggccg
    11161 tcacccgcgc cgcgggcacg ccgacggtgc ggggtacgtc cgtgatctcg tcgaccgccg
    11221 cgtccaggaa ggcgcggtcc accgggaact gactcgccac cacgtcggcg agatgcgccg
    11281 ccttgcgccg gtccagcgcg agcaggctgg tgagcgggag gaacagcgcc agccgcagac
    11341 aggccagcgc gtaccggtcc accgccactc cccgccggtc ggaaggcgcc acgaaccccg
    11401 ggttcgcgac ggtctgccgg ccgggttcgt cgatctggtg cgccgcctcg aagtccagga
    11461 gggtgacgct gccgtcctcc cggagcatga tgttgaacag atgcaggtcg ttgaagacca
    11521 cgccccgcgc gtggacctcc tcgacggccc gttcgacccg ggcgtggaca tcgagggccc
    11581 aggcggtgta ctcggccagc cgctgctcac ccgggtcggc ctcgatgagc ggatgccggc
    11641 gagcgaagaa cgtgttgagc ggtttgccgt cgatgtactc cagcacgagg aaatggtgtt
    11701 ccccgacggt caggtgatcg agcacctcgg gtgtgcagtc gaggcccgac agacgttcca
    11761 gcgcccggcg ttcgcggtgc agccgggtca cggcgtcggc accgtcggct gccagcccgg
    11821 cgtgcggacg ggcctccttg aggacgacct gctcgccggt gcgggtgtca cgggcgaggt
    11881 agacaccgcc gccgttggag aagtgcagtg cggaatcgat ggtgtagggg aggtcggcca
    11941 cggtcaccgc ggagcgggcg tccaggtgcg gacgcaggaa ggtgggcaca ctcacccagt
    12001 ccggcacccg gaacaccgga ccgcggaggt cgggcaccag gacaccgtcg ggaccggtca
    12061 cggccggccg cagctcgccg ctcgcgtcgt agcagttgcg gcgggtgaag ccgccgtagc
    12121 ggacgtgcac ggggccgtcg ccgatccgca ggtcactgag gatgtgcgga ccgggctcgc
    12181 cggccagcag agccgacagc tcgcccgtga tctgttcgaa ccgcgcctcg tccgacgggt
    12241 acaccgtgat gaacttgccg ctgccggcgc ggtccgcgta cttggcgttg cgctggtgca
    12301 gcagataccg gctggggacg aacttgaagg ccgtgccgcc ggcgacgcag taccgccaca
    12361 cgcgttccag cacggactcg gcgttgtcga ggcaggcgga gacatggatc ttccagccct
    12421 ggtcgggcag atccgcgtcc accggacgca gggccagcca gtccccgctc tcgttgcgct
    12481 gccatcccgc cgggacgggc aacgaagcag cggcgtaccg ggaccgtccg gagccgttcc
    12541 ggaccaccgt gcggtgcgga gcgtcgtaga agtgcgggtc cgcgtcgcag tacacggcat
    12601 agcccttgtt cacgccttct ccctcccacc gatcgctgac aggtgagacg ttgtcacgcg
    12661 gccgacgggc aggcacagtt gccgctgtca tcaatccaac gtgcggaacg cacaggtaac
    12721 ttcgggggag ggagccctac cgtcggcagg agcgctcgcc gtgccggcgc tcggaccgcc
    12781 gcctggcaaa cggcgtctcc aacgcccgtg ccctccgggc gtccgccgct cggagggccg
    12841 cgatccgctg ccgcacgccg gtcccaccga tccgcgtcga tggagccggg ggcatcgaac
    12901 tgcttggcgg ggcgggtgcg tgtcactcga cagccgggcc cgtcccgcgg atcgaagtag
    12961 gcggtggaaa gcccgtcacg atggcaccga tgccgctcat ttcccctctg ttcagttggc
    13021 tggactcatc ttgcacagtg agtgctcgac cacatcgacc cagggggacg agacccatga
    13081 ccactccaca aggcataccg agacgcttcg gacggctcac agccgtcgga gccgcgctga
    13141 cagcgttcat ggtcgccgtg acggggacgg cgatccaggc ggcggcctcg ccgaagacga
    13201 cggaaaagcc gcccgtgccg tcgctcacct ggaccgactg ccagggcggc ttcgagtgcg
    13261 cgaacgccga cgtgccgctc gactaccgca agccgcaagg caagaccatc accctggcgg
    13321 tggtccggaa gaaggccgcg gaccagacga agcgcaaggg cacgctcttc atgcagcccg
    13381 gcgggcccgg caactccggc gtggacttcg tacggaacaa ccacgcgacc ctgccggccg
    13441 cgctccgcga ctcgttcgac gtcttcggct acgacgtccg tggcgtcggc cgcagttctg
    13501 cgctgacctg cttcgacgac gcgcggtaca cgcgggccgt caccgaggcc aagggcgtgc
    13561 ccggcccgga cgccttcgag cccgcgctgc gtgaggccgc cgcattcgac caggcctgcg
    13621 tcgacaacgc gggcgagctg ctgccccacg tcggcaccga atacgtcgcc cgggacatcg
    13681 accttttgcg ggaggcgctc ggtgagcagc aactcaccta ctacggacgc tcgttcggct
    13741 cgtacatcgg gaccgtctac gccgccatgt tcccgaaacg ggtgcgggcc ctgactctcg
    13801 acggcgcgta cgaccccgtg cactacgcca accgcccgta cgcctacgac cggccgcagt
    13861 acctggcact ggacggcgcg atgagccgct tcctcgactg gtgcgccgcc gaccagagca
    13921 cctgcgggtt cggcgacggc aacccgcgcg cggcgttcga gaagctcaag gccgacctgg
    13981 acgccaaccc cgtaccgacc gcgaacggcg gccaggccaa cggctacacg ctggtctacc
    14041 ggctgatgtt caacatcaac gagggcaagg tcatctggcc cacgctcggc gcgcaactgc
    14101 gcaaggccca gctgcgggac aacacgtcct tcctgctgcg tccgccctcc ccggccagct
    14161 tcgacttcct gggtccgaac gtggccgtcg agtgcgtcga ccgggactac ccgcgcgacc
    14221 tgcgccggct ggagcggaac gtcgcggcca acgcgaaggc ggcaccgctg ctcggcccgg
    14281 cgatggcgta cggccctccc acgtacgacc accagcacgc caccgcctgc gtccagtggc
    14341 ccggcgagcg cgtcagccgc tacgacggct cctaccgggc gaagggatcg gcaccgatcc
    14401 tcgtcctcgg caccaccggc gaccccgaca ccccgtacag ggacgcggtg gcgctgtccc
    14461 gccggctcga caacgcctcg ctgctcacct tccgggccga ggggcacacc gcgttcggcc
    14521 gcagcgcctg cgcgacggac gcggtcgtcg cctacctggt ggatctcgag gtcccggcct
    14581 ccggcacgac ctgcgcggac gagacgcagc cgccgtcctc cactccgaag gcggccccgc
    14641 ccggcacgac gctcggcgaa ctccgtaacg gcgtcgacga gcgcgtcgag cgcataggcg
    14701 ctgtgagctg acgtagccgc accgatcccg gggcgccggc cgtcgaaggc gggcgccccg
    14761 ggatcggagc gggaccggag cgggattgga gcggggcgca gcggggtcgg ggcatggccg
    14821 gggcgcgccg ctcgcgggcc tgccatcgtg gcccgcgtgg tgcggctgcc gtccgagcag
    14881 cccgaggacg gggacccgca gagggttcgt ccagcaccac cgaaagaccc gcagaaggtt
    14941 cacgagtacc gccgaaaaga ccccgcagaa ggcccatcga gcgcgaaaga ccccgcagaa
    15001 cggttcgtcg gccaccgccg aaagaaccct acagacggtt cgtcgagcac cgccaaaaag
    15061 tccgtgcacg ggaggagtac ggctccgtag tctttccgtt ccgggagggc ttcgtgagcg
    15121 cgaaggggat gccgggtgtg actggcgacg aggtgctgga gatcttggag gcgctccgag
    15181 gaagtgggag cgacgtctgg atcggtggag gctggggcat cgacgccctg ctggggaggc
    15241 agacccgccc gcaccgggac ctggacctca tgcaccgcca ggaacaggag ccgactgtcg
    15301 tcgcggctct ttcccaggcc ggtttcgtcg aatcgctcga ctggcgcccc gcgcgtttcg
    15361 tggtcacgga cgcgacggga cgggagatcg acctgcaccc gctggtcttc gctcccgacg
    15421 gaagcgccac gcaggcttcg ctggaaccgg gacgcccgtt cgtctatccg gcagcgtgct
    15481 tcgtcaccgg caccatccgg cacagcaccg ttccctgcct gtccgccgag cagcaggtgt
    15541 acttccacca gggttacgag cccaccgacc gggaccgcca ggacatggcc cggctccgcg
    15601 aagcgttcgg gatcagtacg cacttctgat gcgccgcaca cgcctgaccg gaacgtcagg
    15661 ccggcggttc cgccagagca gaggatgcgc tcgtccgcac atcgaacgac accgctgact
    15721 cgcctgcgtt ccagcggcgt tgacgtctcc tcgcatgctc ttgaagccgc tcgacgcgtg
    15781 cggagcgacg tgagagcccc gacgggcgga accggacgcc cgtcggggct ctcggcatcg
    15841 cgtgacctga aggcgcgatc gaccggtggc gccgccccgg acacgccacc cgcacgacgg
    15901 tcacccggcc cggttctccc gggcgcgggt ggcggcgagg gtgccgagga gggccagggc
    15961 ctcggcgctg ggggagcccg cctcggcgtg gtggacgacc agttcctggc cgggcgcgga
    16021 ccgcacgtcg aacacctgga cgcgcagcgt cagttcgccg acgtcgggat ggtggaaccg
    16081 cttgctccgc aaccgcttgc ggcgtgcgtc gtgccgtttc cacagccgca cgaactccgg
    16141 gctccgctcg gtgagcgtgc gcagcacctc gtggaggcgc gggtcgtgcg ggtcgtcgcc
    16201 gtgcagcatc cggaatccgg ccacggcgtt gaccgccacc gactcccagt cggggtagag
    16261 gcggtgggcg tccgggtcca ggaagacctt cagcatcagg ttcggcccct gccggaagcc
    16321 gtcgaacagg gcgtcggcca gcgggttcac ggccaacacg tcgtaggcgc ggccgagcac
    16381 gatcgccggg gtcgcgggcc acatctccat caggctccgc aactgggggt cgacccgctc
    16441 ggccgccccg ctgctgcgct ggcccggcgt gagaccggcg acccggtaca ggtgcagccg
    16501 cgcgtcgtcg tccagccgca gcacccggct caacgcgtcc agcacctggg ccgacgggcc
    16561 gcgctcccgc ccctgctcca gcctggtgta gtagtcgacg ctcatctccg ccagcatcgc
    16621 gacctcttcg cgccgcaggc cgggcacccg gcgtgctccg cctgccggga tccccgccga
    16681 ctcgggccgc accagcgctc ggcgcgcccg cagatagtca cccagtggtg tcgtaggcat
    16741 acgtccagcg taggcaggtc ccacacaccc gtacctgggt gcgtcacacc ctggcacacc
    16801 cgcttcagcc gccgtacgcc cacgtcgcac cgcccgccga ggcgtgagcc gtgccagggt
    16861 gcgccactcc cgggtgcggc acggcctgcc ccgtccccga gccacggtcg accatcgggg
    16921 acgtgaccga gaacaacgcg aacacaggac ccgtacacac cgaatcgctc gcacccgaca
    16981 cctcgaaggt ggtgctggtc acgggcgccg ccagcggcat cggcagggcg acggcctgcc
    17041 gcctcgcccg cgacggtcac cacgtggtgc tgaccggccg ccgcaccgac ctgctgaagg
    17101 agacggcgga cctgctcacc gaggagggaa gccgggccga ggcccggtac ctcgacgtca
    17161 ccgaccgcac cggctacgcg gacctggtcg acgacgtgct cgccgagcag gaccgtatcg
    17221 acgtcctcgt cggcaacgcc ggcgtcatgc tcctctcccg cctggagtcg gtgctgaccg
    17281 acgagtggga ccggatgctc gacgtgaacg tccgcggcct ctaccacggg atcgccgcgg
    17341 tcctgccgca cttccgggcc cgcggcacgg ggcacttcgt caccgtggcc tcgatcggcg
    17401 cccaccaggt ggtgccgacc tccgccgtct acagcgccac caagtacgcc gcctgggcgc
    17461 tcaccgaggg actgcgccag gagtccgtac ccggtatccg ggtcaccacc gtctccccgg
    17521 gcgtggtcga gagcgagctg gccgaacaca tcaccgaccc gtacgcggcc gaggccatgc
    17581 ggacgtatcg ggccgccgcc atcccggcgg acgccgtcgc cgacgcgatc gccttcgcga
    17641 tcagcaggcc cgacgacgtg gacgtcaacg agatcgtcgt ccgccccgcc gcccaacgct
    17701 gaaccggacc accggccggc cttccacgca ccgctcaccc ctgccgcgga gcttcaccat
    17761 gtccggtacc tggctgatca cgggcgcctc ccgaggcttc ggcatggcct ggtcactgcg
    17821 tcccgcccat caggcgtgca cgagccggtc gcgccgctac cgcaactcga cgcctggccc
    17881 tggccctggc cgtgatggcg cggtggtgtg acgagatggg tttggggtcg ttcgggtggt
    17941 ctgtcgcagg ttgtgcaact ggagaccggg caggccgcct cctggacacc aagtgaacgt
    18001 cgaacactgg aggttgcatg caggagtgga cgtactcacc gaccgcggtc acggtgcctc
    18061 agttgatgct cgacccctac cgctgcggct tcgacgcgca tacggctctg ggggaagcgg
    18121 agacgcaggg acagtggggg gacgaggact ggcgcgtgcc gccccaggcg cggaccgagg
    18181 aggaggcgcc gtggtccgct cccgacccgg gcccccggcc gcccctggct ccggccgacc
    18241 gccgccggct cgaactgcac gcggcactcg tccgagcggg agtcgcgccg gcgcccggag
    18301 acctgcacgc cgtgacagtg ttgagcaccc tcgacgacac cgtcaacgac gccgtccgac
    18361 gctggatcgc cgcgtactga gcatgtcgga cagtgagccg caccgggtgc cggagcgtag
    18421 gacacgggag ggtcgaccag gcatcggccc tccctccggg ggtacttcgg ggtctctacg
    18481 gctgctgggc gcactcgagg tgttcgaggg cgcggcggcg gcgagggccc tctcctcggg
    18541 tcccgcagcc gggggtcagg cggtgcagca gagcactgcg ggggtcggcg atgaccgcgg
    18601 agcggagcgg agcggggcgc gattgcgtcg gcgtcggcat cggcatcggc gtccgcgggt
    18661 gcgggtgcgg gtgcgggtcc ggttgtgggt gcgggacggg cggtggccgc ggtctgcggg
    18721 cggcctcgcg tgaagacggc gaggcgcagc acggcgaagc gtgcgatacc agcgagcgcg
    18781 gaggcggaca ggtagacggc ctgctcgagc atcgcgctgg gtgttgcgac cagctgctgc
    18841 agggcaagca ttgccgcgca ggtcaccgag taggcggccg ccgcggaccc tgccgactgt
    18901 gcgtgctggc gccgggtcgc cggcctgccc gcgccgaagg tgaagcgggc gtgcagttcg
    18961 gtggcgagga acgtggaggc cacggtgatc agtgcgttgg ccagcaccca gggaatgcac
    19021 gaggcgaggg ctgccacggc gaagccggag gtgaggccca ccccgccgcc gagaagcacg
    19081 aagcgggcga aggcggtgac ggcgccgggt gccgcccgct gccggctatc cgctgtctcc
    19141 atgttctgac cccccattga tcgctcgctt cgcgaacggg catccttcgg cccttgcggc
    19201 ccgccgcttg atgtttccta tgatggaaac gctacgttgc gttcatgggt cgcgcaattc
    19261 atttgttgcg catggcgcat gaaagtgcag gtaggggcga tgtaatcgtt gcaatgggat
    19321 gatggtaacg caatggagtt attcttcttc gttgcaatgg aatggaagtg aacgctatat
    19381 tcggagaacg ggcgcgccgc ggccctgttc ttggcgctga gtgcactcgc ggtgctcgcg
    19441 cggatggcgc atcgtgacgt cccgttcccc gttccccgtt ccccgtggcc ttggcgcagt
    19501 tgcgcctggg cggcgacgat ccggccgttc ggcgcgcccg tgtcctgtcg acccgcctgc
    19561 tgagcctgcg ggtgcgcggc gagacgggcg acctggccga ccgcctcaga caggacggcc
    19621 gtaccgacga ggccgaagcg gcgtcgaggt ccggtgcacc tcgagcgcgc tcccgagacc
    19681 ggcgagccac gtgtctgccg acttgagggt gcgaggccgg caccagggcc cgggccgtcc
    19741 gcagcggggg cctaatcgcc tttcgcgtcg gttcggccac ggctagtgtt ccggtgcggt
    19801 gagtgatcca cgaggagttg aggacatggt cggtcgtccg agcgcgcgtt gacgttgtgg
    19861 accgtgatcg gtctgtcata gcgtgctggc cctgtacgtg cggcacagcg agccttctcc
    19921 tgcccgaata gtcggtgcac ctgtgtgcga cgggtgacgg gcttcgttgt cggcaatcca
    19981 agggatcctc gtgccgcccg cttcctgtgc tgcatccgct tccggtcggc ctgttccgtc
    20041 acgtctgtgg cgggacggcg acttccgcag gctctgggtg ggccagacgg tctcccaact
    20101 cggtgaacac acaactctgg tggtgttgcc gctcttcgcc gtcctgacgc tcgacgccgg
    20161 ggccggccag ttgggcgtcc tgcgcgcggt ggggcaggca ccgatcctcc tgctctcgct
    20221 cttcgtcggc gcgtgggtcg acaggtggcg ggcccgcacg gtgatggtgc tgacggacgt
    20281 cggacgggcc ctggcactgg gcgccgccgc cgtggcaggc ctcctcggct ggctcggact
    20341 gccggcgctg ttcgtggtcg ccttcgccgt cggtgctctg tccgtcttct tcgacgtggc
    20401 gtatcaggcg tctctcgtac ggctggtgaa gcgcgatcag ctagtggaac gcaacagtgc
    20461 gctcgagggc agtcggtccg cggcgcagat cggcggtccc gccctcggcg gcgcgttggt
    20521 gtcactgctg tcggcgccgg tcgctgccgc ttccagcgcg ttgttcttcg cgttgtcctt
    20581 cctgtccatc cggcggatcc gtcggagcga agcgctcccg aagggcccgg aacgtccccc
    20641 tcgggtctgg cggcgtatcc atgagggcct ccggttcgtt gtcggcgatg cctcactgcg
    20701 gaccgtgtgt ctcgcctcgg ccgccttcca gttctccctg gcggccgtga tgaccgtcta
    20761 tctgctcttc ctgccgcggg aacttcacct gtcgggcacc gccgtcgggc tggcgctcgc
    20821 ggcgaccgga ccgggtgcgc tcctgggctc ggtgctggcc gcccgcctgc cgcgccggtt
    20881 cgggcatggg gcggtactcg tgtccgcggc ggtgctcggc gacggcgtgt tcctctgtgt
    20941 gcccgcgctg cacggctcct ccgcggtgac gctggctgcc ctgctcgccg tcaatttcgt
    21001 gttcggtacg ggcggccagt tggtgaacgt cacggtcatg gctgtcaggc aggccgtcac
    21061 tccggacggg atgcaaggcc gggcggccgc gacgatcacg ttcgtcggca tggggctcac
    21121 cccactcggc tccctgctcg gcggactcct cgcggaggaa tgggggttgc gcaccagcct
    21181 cctcgtgacg gccgcaggca tgttgctctc cccgctgctg atggccctgt ccccgctcgc
    21241 acgcctggga cgggcgcttc cgtcccccgc aggtcccgcc accgagccac gaactccctg
    21301 agccaccggc gggcccgaca cccacgaggg gaccggggcg gtcctgccgt cctttacccg
    21361 tgaggaccct tctggcatgc ctccgagcgc cgagcgccga acgccggccc ccgacggccg
    21421 gacagcgaag tgagagtgga gggccaggcg ggcggcccag cccatcgtgg ctcggcagtt
    21481 catctggcga gtgagccgtt gaccttgcgg ggctgagcgc tgtagtcggc gggctgggca
    21541 tcgcggctgg cgagcgagtc gctcagtgtc cggcgacggt gcggatgccg ttgcagagca
    21601 agtgcaggga gcgggtgcag agagccggtg cagagagcga gtacctagga tcgccggcat
    21661 gacactgcga cctgtccagg tgaacataaa ggctcgtgac gactcggcgg tcggccggtt
    21721 ctgggcggag gcgctcggct ggcgtgtttc cagctcggga cccggcgcga ccgccgttca
    21781 acccgtcggc ttcgactggc tggaccccgt caccgtatgc gtcgacgtca ttgccgtacc
    21841 ggaatccaag acgacgacga agaaccgtgt gcacctcgat ctcgccacca cctccgcggc
    21901 ccatcaggcg gagttggtcg agcgtctccg ggctctcggt gcgacgcccg cccacgtggg
    21961 ccagggcgac gtgccgtgga cggtcctcgc cgacccggag ggcaacgagt tctgcgtgct
    22021 ggagccccgg gagatctacc gggacaccgg gccgatcgcc cggatcgtgg tcgactgcgc
    22081 ggttccgccg gacatggccc ggttctggga cgaggcgatg gactggaccc tgtgcgaggt
    22141 gactgacgat cgtgcggtgt ggcgctccgc ccagggggtc ggcccgtacc tcgagttcct
    22201 ccgcaccggt gtgaagaccg tgccggaccg cgtccatctt gacctggtgc cggagcccgg
    22261 tgacgacaag gcggcggagg tggcccggct gcgggccctc ggcgccaccg acctcgacct
    22321 cggccagggc gacgtcccgt ggacgtgcct gaccgatccc gagggccacg agttctgtgt
    22381 cctcgcccgg tcctgacgcg gagcctcgac gacaccccga cacacgtgag ccgcgggtgc
    22441 tcatgcgcca tgatgccggg tgaggtgagg tgaggtgagg tgggcggtca ggtgaggtga
    22501 ggtgggcggt gaggtgaggt gggctgcggc gtctcggtga ctgagtgctt ggcccggccc
    22561 tcgacccatg tcatctgccc cttcgagtgc cgggttcggc cggtgcggag gtg
//
