LOCUS       NZ_CP099468            26578 bp    DNA     linear   CON 04-JUL-2024
DEFINITION  Streptomyces phaeoluteigriseus strain Qhu-M197 chromosome, complete
            genome.
ACCESSION   NZ_CP099468
VERSION     NZ_CP099468.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces phaeoluteigriseus
  ORGANISM  Streptomyces phaeoluteigriseus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
REFERENCE   1  (bases 1 to 9026270)
  AUTHORS   Zhang,B., Xiang,X. and Fan,J.
  TITLE     Complete genome sequence of soil microorganisms Streptomyces sp.
            Qhu-M197 isolated from Alpine meadows habitats on the Tibetan
            Plateau
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9026270)
  AUTHORS   Zhang,B., Xiang,X. and Fan,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-JUN-2022) Faculty of Eco-Environmental Engineering,
            qinghaiuniversity, No. 251 Ningda Road, Chengbei District, Xining
            City, Qinghai Province 810000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: Hifiasm v. v0.14; Circlator v. v1.5.5; Pilon v.
            v1.22
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 68.51291x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023923245.1-RS_2024_07_04
            Annotation Date                   :: 07/04/2024 06:06:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,100
            CDSs (total)                      :: 8,006
            Genes (coding)                    :: 7,707
            CDSs (with protein)               :: 7,707
            Genes (RNA)                       :: 94
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 299
            CDSs (without protein)            :: 299
            Pseudo Genes (ambiguous residues) :: 0 of 299
            Pseudo Genes (frameshifted)       :: 130 of 299
            Pseudo Genes (incomplete)         :: 241 of 299
            Pseudo Genes (internal stop)      :: 34 of 299
            Pseudo Genes (multiple problems)  :: 90 of 299
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:40:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3392658
            Orig. end                         :: 3419236
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP099468.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26578
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="melanin"
                     /product="terpene-precursor"
                     /region_number="12"
                     /rules="melC"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..26578
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="neighbouring"
                     /product="melanin"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..10396
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10396
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5396](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5396)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            905..1912
                     /locus_tag="NFX46_RS15070"
                     /old_locus_tag="NFX46_15070"
     CDS             905..1912
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670640.1"
                     /locus_tag="NFX46_RS15070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15070"
                     /product="MASE1 domain-containing protein"
                     /protein_id="WP_252549552.1"
                     /transl_table=11
                     /translation="MAAVVGTSDLRRPAVLAAETAAVAVGYYAAGKLGLLRQLVVEGAI
                     FTPIWPPSGVAVACLLILGLRCWAGIALGALLVILSLTSLSPSVVFNLAGNTAAPVCAY
                     LMLRRVGFRNDLARLRDGLALVFLGALTAMLLSSTVGVGVLFITDQLPAHAFWPVWLAW
                     WVGDAMGVLIVTPVLLVVHAARRRPPLTRWKEAVGLAVIALALIPLATNSHVSLLFLVY
                     PLLIWSALRFQLAGSMLCALVSSVLATVAATDGVGPFAGLTRVEVMSKLQAFNGTMALT
                     ALLLSAVITEQRNTRRSVEQACQELVEVLEHLTAGEAPYGRPPKDMEDGPPGGT"
     gene            2006..2803
                     /locus_tag="NFX46_RS15075"
                     /old_locus_tag="NFX46_15075"
     CDS             2006..2803
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031563.1"
                     /locus_tag="NFX46_RS15075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15075"
                     /product="VOC family protein"
                     /protein_id="WP_252549555.1"
                     /transl_table=11
                     /translation="MAVQPEGTPCWADAMFSDVEGAKRFYGDVLGWTFGESSSEYGNYT
                     QAYADGKAVAAVVPPMPGQEGQSAWCLYLAAEDATGTAARIRENGGEVLMGPMRVGEFG
                     TMCLAREPSGAVFGVWQAGSHEGFDVMGVPGAYAWAEVFTREPEKADTFFSAVYGYGQK
                     QMEDEGGDFRLYDLGDEPVLGRMEMGDDFPPEVPSYVNVYFTVPDCDEAVAKATELGGR
                     LWFGPMGTPFGRFAILTDPQGANFSVIDVTTTEGEMPQTRDVS"
     gene            2834..3568
                     /locus_tag="NFX46_RS15080"
                     /old_locus_tag="NFX46_15080"
     CDS             2834..3568
                     /EC_number="3.1.26.4"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004523 - RNA-DNA hybrid ribonuclease
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031564.1"
                     /locus_tag="NFX46_RS15080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15080"
                     /product="ribonuclease H"
                     /protein_id="WP_252549558.1"
                     /transl_table=11
                     /translation="MIVRMRERVVAACDGASKGNPGPAGWAWVISDASEAPARWEAGPL
                     GRATNNVAELTALERLLAAVDADVPLEIRMDSQYAMKAVTTWLPGWKRNGWKTAAGKPV
                     ANQELVVRIDELLGGRTVEFRYVPAHQVDGDRLNDFADRAASQAAIVQEPAGSALGSPE
                     PPPAPDVPAKAAVRRKANGGNGAGGATGGTSARRPGGSSARTIKAKFPGRCVCGRPYAQ
                     GEPIAKNDQGWGHPECRTTAAG"
     gene            complement(3614..4066)
                     /locus_tag="NFX46_RS15085"
                     /old_locus_tag="NFX46_15085"
     CDS             complement(3614..4066)
                     /NRPS_PKS="Domain: Polyketide_cyc (9-129). E-value:
                     2.9e-18. Score: 58.3. Matches aSDomain:
                     nrpspksdomains_NFX46_RS15085_Polyketide_cyc.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020138611.1"
                     /locus_tag="NFX46_RS15085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15085"
                     /product="SRPBCC family protein"
                     /protein_id="WP_073494610.1"
                     /transl_table=11
                     /translation="MTQVEESIEVGVPVHTAYNQWTQFETFPEFMDGVERVEQRSDTLT
                     HWVTDVNGVHREFDAEITEQIPDERVAWTTVSGEARQSGVVTFHRLDDEHTKVMLQMAF
                     EPEGLAETVGDKLGFVKRQTKGDLQRFKKFIEERGLETGGWRGAVV"
     aSDomain        complement(3680..4039)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NFX46_RS15085_Polyketide_cyc.1"
                     /domain_subtypes="Polyketide_cyc"
                     /evalue="2.90E-18"
                     /label="NFX46_RS15085_Polyketide_cyc.1"
                     /locus_tag="NFX46_RS15085"
                     /protein_end="129"
                     /protein_start="9"
                     /score="58.3"
                     /tool="antismash"
                     /translation="VGVPVHTAYNQWTQFETFPEFMDGVERVEQRSDTLTHWVTDVNGV
                     HREFDAEITEQIPDERVAWTTVSGEARQSGVVTFHRLDDEHTKVMLQMAFEPEGLAETV
                     GDKLGFVKRQTKGDLQ"
     gene            complement(4143..4967)
                     /locus_tag="NFX46_RS15090"
                     /old_locus_tag="NFX46_15090"
     CDS             complement(4143..4967)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662973.1"
                     /locus_tag="NFX46_RS15090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15090"
                     /product="tyrosinase family protein"
                     /protein_id="WP_252549562.1"
                     /transl_table=11
                     /translation="MTVRKNQASLTADEKRRFVAALLELKRSGRYDAFVTTHNAFIIGD
                     TDNGERTGHRSPSFLPWHRRFLLEFERALQSVDASVALPYWDWSVDRSPRSSLWAPDFL
                     GGTGRSRDGQVTDGPFAASSGNWPITVRVDGRTFLRRALGTGVRELPTRAEVDSVLAMP
                     TYDMAPWNSGSDGFRNHLEGWRGVNLHNRVHVWVGGQMATGVSPNDPVFWLHHAYIDKL
                     WAEWQRRHPQAGYLPAAGTPDVVDLRETMKPWNDTTPADLLDHTPHYTFDTA"
     gene            complement(5001..5396)
                     /locus_tag="NFX46_RS15095"
                     /old_locus_tag="NFX46_15095"
     CDS             complement(5001..5396)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020138613.1"
                     /locus_tag="NFX46_RS15095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15095"
                     /product="tyrosinase cofactor"
                     /protein_id="WP_252549565.1"
                     /sec_met_domain="melC (E-value: 1.6e-49, bitscore: 166.6,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPELSRRRALTTAAALAAAATATGTAAAHSTHAAPSDSPNSPGAP
                     GSFDEVYKGRRIQGRPAAGGGHHGGGHHGGGYAVFVDGVELHVMRNADGSWISVVSHYA
                     PVPSPRAAARAAVDELQGARLLPFPTN"
     misc_feature    complement(5433..5446)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.81"
                     /tool="antismash"
     misc_feature    5519..5532
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.14"
                     /tool="antismash"
     misc_feature    5525..5540
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.3"
                     /tool="antismash"
     cand_cluster    5559..26578
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    5559..26578
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[15558:16578](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(15559..16578)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="2"
     gene            5747..6991
                     /locus_tag="NFX46_RS15100"
                     /old_locus_tag="NFX46_15100"
     CDS             5747..6991
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020138614.1"
                     /locus_tag="NFX46_RS15100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15100"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_252556485.1"
                     /transl_table=11
                     /translation="MCVKVACVGGGPAGLYLSILLKRQDPSHDITVHERDPEGSTYGWG
                     VTYWRGLLDELHARDPESARAVEEHSVRWNQGVAHVRDLVTRQPGDAGHGIGRHKLLEI
                     LTARARALGVRLEFEREITPDDLPEADLVVAADGVHSALRTRHAQHFGAALTPGRNPYV
                     WLGTTKVFDSFTFAFVETGHGWIWCYGYPFSADRSTCVIECAPETRTGLGLDRANDADG
                     TARLEGLFAHILDGHPLIGRASGDGGAPWLTFRTLTNRTWYRDNVVLLGDAAHTTHYSI
                     GAGTTLALEDAFALADALRECPVLPQALARYERDRTAALLTPQSAARHSAQWYENLARY
                     IDLPPEQMFALLGQRHSPLLPYVPPQLYYRLDKAAGRLETLRRLKRWLGPRLARTAQTA
                     QTARTAQAGTAASRK"
     gene            7158..8141
                     /locus_tag="NFX46_RS15105"
                     /old_locus_tag="NFX46_15105"
     CDS             7158..8141
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433219.1"
                     /locus_tag="NFX46_RS15105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15105"
                     /product="aldo/keto reductase"
                     /protein_id="WP_252549568.1"
                     /transl_table=11
                     /translation="MDEREFGRSGQHASVIGLGTWQLGADWGDVDDKEALAVLEAAAES
                     GVTFFDTADVYGDGRSEQTIATFLGGRPDLHVLVATKMGRRVDQIPENYVLDNFRAWND
                     RSRRNLGVDRIDLVQLHCPPTSVYSTDEVFDALDTLVEEERIAHYGVSVETCAEALTAI
                     ARPGVASVQIILNPFRMKPLYEVLPAAREAGVGIIARVPLASGLLSGKYTKDTVFPEND
                     HRTYNRHGESFDQGETFSGVDYATGVEAAAEFSALAPEGCTPAQLALRWIVQQPGVTTV
                     IPGARSPEQARANAAAARLPELSEETLAAIRDLYERRIKDQVESRW"
     gene            8224..8718
                     /locus_tag="NFX46_RS15110"
                     /old_locus_tag="NFX46_15110"
     CDS             8224..8718
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998725.1"
                     /locus_tag="NFX46_RS15110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15110"
                     /product="DUF6328 family protein"
                     /protein_id="WP_289782060.1"
                     /transl_table=11
                     /translation="MATAVGDERRRGRNETEEERADRMWGELIQEVRVAQTGVQILFGF
                     LLTVVFTPRYASLEDVDRAIYIVTVVLGACATGALIGPVSLHRLVSGRRVKSQAVTWAS
                     RMTFVGLMLLLATMTSALLLILRVATHDGYVPYLVTGVLVWYLVFWFGVPLWTRHRYSS
                     R"
     gene            complement(8792..9829)
                     /locus_tag="NFX46_RS15115"
                     /old_locus_tag="NFX46_15115"
     CDS             complement(8792..9829)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010356458.1"
                     /locus_tag="NFX46_RS15115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15115"
                     /product="hypothetical protein"
                     /protein_id="WP_252549571.1"
                     /transl_table=11
                     /translation="MTVAIDPSETSAAAASPAPLSDLVARDAREFGVYARTGGWAFGLM
                     VARSVRPGGQSAQETPKVSAKEFAELAGCSAERVMRHYKAWDRAADDGLVPHFEELAPG
                     QEVELPDADVWLTYYVSRSSASSERGTAIAEAAEAEGIRPTKALEVAENPTALRAAILA
                     DPSTARAARAALLDRIKEDPELQSELARDVVRTDDLKKAVASESRSADRIGYVRQIAES
                     GRIKTPAGQTVDAPADLRQEAERHLSLLDELDEGEDSGEWATEAYDTLKTLVVEAVEAD
                     PELRVQERRTKFYSGLQKATKVFEELTFDDAQDFYEDDMVKQLEELQQAIGGCIAALRG
                     ARATD"
     misc_feature    9833..9847
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.26"
                     /tool="antismash"
     gene            complement(9955..10926)
                     /locus_tag="NFX46_RS15120"
                     /old_locus_tag="NFX46_15120"
     CDS             complement(9955..10926)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020138623.1"
                     /locus_tag="NFX46_RS15120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15120"
                     /product="LLM class F420-dependent oxidoreductase"
                     /protein_id="WP_252549574.1"
                     /transl_table=11
                     /translation="MVRIGYTMMTEQAGPRDLVDHVVRAEEAGFDFSVTSDHYFPWLRS
                     QGHSPYAWSVLGAAAQATSRIPLMTYVTCPTVRYHPAIVAQKAATMQLLSEGRFRLGLG
                     SGENLNEHVVGGGWPAVDVRHEMLEEAVEIIRALFEGGHVTHHGTHFDVDSARLWDLPD
                     VPPEIGIAVSGEQSCALAGRLADLVIATEPKAGLLDAFDRHGGAGKPRVGQLPVSYDPD
                     RDTAVKRAHAQFRWFGNGWKVNAELPHPDSFESATQFVTPDDVAASIPCGDDPDAFVEA
                     VRPYAEAGFTEIALVQIGGDTQPAYLDWSEKTLLPALRDAFA"
     gene            11034..12473
                     /locus_tag="NFX46_RS15125"
                     /old_locus_tag="NFX46_15125"
     CDS             11034..12473
                     /EC_number="3.1.1.103"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007379775.1"
                     /locus_tag="NFX46_RS15125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15125"
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_252549577.1"
                     /transl_table=11
                     /translation="MSARPLPDSTPSAQGVDASGVLAFLDAVDAAGTIEPHSLMVLRHD
                     HVVAAGWWAPYTPDRLHLLYSLSKSFTSTAAGFAVAEGLIGLDDPVISYFPEFDADITD
                     PRSRAMRVRHVASMASGHEAETLDRARALDRDDLVRGFLLLPPDRDPGTVFAYNQPATY
                     TLAAIVQRVTGQSLTAYLRPRLLDPLGFGEVAWLTDRTGRELGFSGLHGTTDAIARLGR
                     LYLREGDADGRRLLPREWIAQATREHIPTAGAMGDTDRQDWDRGYGFQFWRSRHGYRGD
                     GAYGQFCLVLPEHDAVIATTAATPDMHGLLNLVWEHLLPAFRPAPLSGRQDADAALADR
                     LTRLALPPAPGKPVPPDRPRAWSGAAFTPYGGVCADQPSLTGVRVTADGDGWTLTLAEG
                     DERLAPRLGPGGWTVTEEPVPVAASGGWSDGDTLAVDLAFLETPHRLRVTCSLPARTFT
                     ARWATQPLHGGTLHMRCAPRS"
     gene            complement(12562..14223)
                     /locus_tag="NFX46_RS15130"
                     /old_locus_tag="NFX46_15130"
     CDS             complement(12562..14223)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126219.1"
                     /locus_tag="NFX46_RS15130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15130"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_252549579.1"
                     /sec_met_domain="Pkinase (E-value: 5.9e-18, bitscore: 64.0,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTMVKAHVSEHELVAGRYRLLDVVHRETNRVGWYGEYADDSAGTR
                     PCLITRIGLPTGLGEEDAHRAAERVVRMSETMARVCPGRVATVLDALAEAGSLWTVTEW
                     IDGLPLGQLIEQRRVFPHARAARIGLELLDVLEVAHGQGITHGELSPGQVFVRAHGPVV
                     VTGFGLAGVALAPRLAAPSYASPEQARDERIGPAADLWAVGAILYTMVEGRPPYRDRDR
                     PEATLKGVDRLPLRTPLRAGPLGPAIQGLLRKDSRERMTRPAVRHSLARVLDEDTHGVP
                     EPRLRRAYAVERVAGPGWNGRAVAGGTALAVIAMTVAVLAATGQLPGTESTSSDSARTR
                     PTAPSAPPGEDRADEVTDVPTPAPSPPAASSPPAASAGPTPTSAPTPTAASPSATAGAL
                     PAGFRVFRAQEGFSVALPEDWTRLDTTRTGDLAYRVTFGAEGDPRTLAVTYSERVGPDP
                     VAVWRDDVEPGLRRADGFARIGAIEATTYRGYEAADMEWVVDVDGTRVRTFGRGFLLGD
                     HRGFSLRWTTPAADWDEAANGRALDTFLSTFRPGSA"
     misc_feature    14319..14332
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.72"
                     /tool="antismash"
     misc_feature    complement(14320..14333)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.5"
                     /tool="antismash"
     gene            complement(14511..15470)
                     /locus_tag="NFX46_RS15135"
                     /old_locus_tag="NFX46_15135"
     CDS             complement(14511..15470)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031570.1"
                     /locus_tag="NFX46_RS15135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15135"
                     /product="threonine/serine dehydratase"
                     /protein_id="WP_094103139.1"
                     /sec_met_domain="PALP (E-value: 1.7e-71, bitscore: 239.9,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGITDIEAAAERIAGHVVRTPTLPSPGLSGLLGVPVTVKLELLQ
                     RTGSFKARGAAAKLLSLGEAERAAGVVAVSGGNHGIAVAVMAAALDVKATVVMPRSAPA
                     RAIEIAEEAGASVRLTDGMGSAFSLVNDLRDEGLTLVHPFDDPVVIAGQGTVGLEFARD
                     ADELTDVLVSVGGGGLISGVATALRALRPQVRIWGVETEGAEAMAEALKAGGPVPVEVS
                     SISTTLSAPAVAPLTYEHVAALVGEVLVVPDREAVRGCLELAEHAKVWTEPAAGCLLPA
                     ARRVVERVGPDARLGLVVCGGNASAVDMASWVERFGLR"
     misc_feature    complement(15447..15461)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     misc_feature    15457..15470
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.16"
                     /tool="antismash"
     gene            complement(15559..16578)
                     /locus_tag="NFX46_RS15140"
                     /old_locus_tag="NFX46_15140"
     CDS             complement(15559..16578)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010033177.1"
                     /locus_tag="NFX46_RS15140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15140"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_252556488.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.9e-57, bitscore:
                     193.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPTPPVAPAVLDRCRALVRPALAEAVGRLHPWVGEMAAYSLGWC
                     EVGGAPAAASGGKGLRQALAVLGAEAAGAPARAGVAAAVSVELVHTFSLLHDDIMDGDP
                     TRRSRPTVWKAYGTGPAVLAGDALFALAVETLAAAPGGAGGVRLLSGALAELVHGQADD
                     LLFAARPWSGPERVRPEAYRAMAEGKTGSLLGCAVALGAVLGGAPEATVIALDRAGRHL
                     GIAFQVVDDLLGIWGDPAVTGKPVHGDLRAGRKTFPVLAALESPAPAARRLARLLESGG
                     DPAEAAVLAEEAGGRTAALAEARRQVSAVESALAGVPLRTRAAGDLRSLLDFLVRRDL"
     gene            complement(16647..17717)
                     /locus_tag="NFX46_RS15145"
                     /old_locus_tag="NFX46_15145"
     CDS             complement(16647..17717)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004991900.1"
                     /locus_tag="NFX46_RS15145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15145"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_252549581.1"
                     /transl_table=11
                     /translation="MYGKASAPEYQGALTTLSVNSSLVDVLAAGTERLAAAERAGERAE
                     VARSGLAVAEAHRRLGQVREADLAWKASYRAARDAGDVAAMAWALWSGGTLARQRGAFP
                     LARRLLGLAADLGERGGDVVVRGYSLAGLAETGRIQGDYEAVGRLHEQLLAEARRRGEA
                     RHTVWALEGIAQMHRNSGDLDTAHALFEEAAEISARADDRRGHAWALRGLADVVSIRDG
                     DTERALALLSEAETTCRAMNLTGALAYNHKMRGNVLYRAARYAEARDLYERALAEFGAM
                     SEPRGKALARLGLAKSLARLGRDRSETAKELTALAGELERIGLRHAREMVDRAEQELGI
                     GTDPAGPRCVTAEAVR"
     gene            complement(17927..19255)
                     /locus_tag="NFX46_RS15150"
                     /old_locus_tag="NFX46_15150"
     CDS             complement(17927..19255)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1296: tellurium
                     resistance protein, TerD"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126222.1"
                     /locus_tag="NFX46_RS15150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15150"
                     /product="CAP domain-containing protein"
                     /protein_id="WP_252549583.1"
                     /transl_table=11
                     /translation="MSELVAGANVALPEGALAVRVSGPFDVCALVTDDSGKVGGDGDFV
                     FYNQPTAPGAGLRGGTLTLEPARLRAGATRVTVVVSAVEPGTRPGGLPAPTLQVTDRQG
                     RPLARFTPAPARQETVLLLAEVYRRGGVWKLRALGQGYADGLAGLARDFGVEVADEGTA
                     AQGSPAPRTAAAPAPASVRAPDPERFLGPVNSARAAVGSPPVSLDARLVSAARAHVTAM
                     TAAGRLGTMGADGVSVHQRVTAAGFRYLAVGEHLVSGPRTSAEFLGYCLRTDQARRTLH
                     DPAFTHAGLARAEDGRTGDVLWTALWASPLTPAGLAGTEAEVVDRTNRERARAGLRPLA
                     VDPLLATAARAHSADMVARSFYSHTSPEGGRPWDRAAAAGSARRTIGENIACGQRSPAE
                     VVEGWMNSPGHRANILKPAFTHIGVGFAGGGPSGTYWTQLFGA"
     gene            complement(19345..22308)
                     /locus_tag="NFX46_RS15155"
                     /old_locus_tag="NFX46_15155"
     CDS             complement(19345..22308)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126223.1"
                     /locus_tag="NFX46_RS15155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15155"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_252549586.1"
                     /transl_table=11
                     /translation="MPPTAFATVFIGRDEEIARLSGVLERARAGEARAVLVAGDAGVGK
                     TRVLDEIAARAARTGTTVLTGHCVDLGDVGLPYLPFTEILGALAGDERFAAVLAGHPVV
                     DRLLGGGPDDAVRDLGGRLRLFEGMAGLLADLAEVNPLLIVLEDLHWADESSRDLLRFL
                     LSRGVLQRPAGGAPAHRLALLTSYRADDLHRRHPLRPLLAELVRLPGVERLELRPLADA
                     EVTRLVRALEDRPLPDTTVRRIVERAEGNAFYAEELLAATDTGAGGVPSGLADLLMIRV
                     EQLSETAQLVLRTAAVAGRRVEHDLLRDAVALPEDELESALREAIGRQLLVAGAGDTYA
                     FRHALAREAVYADLLPGERARLHGAFARLLGGRGHRAETAAERAHHYRESHDLPEALTA
                     SLEAADHAQRVGAPAEELRQLETALDLWPTVDASARPSGEGMDRVTLMLRASAAAAHAG
                     QGHRAVSLTRAALAGVGQDADSELAARVRYTLAGTLLGVDSLTAAFRYSSEALAMIPAE
                     PPSPTWVWAAATHVLAARQVGETETARRVARQALAVADQLKVTDAQADLLISLAVLEGG
                     GRRSPEGRERLREARELARRAGSAPVEMRALFNLAIGCYEAGEFEECLPWLADGLDRAR
                     RAGLLSSPYPLEMRYLQLLLLHTLGRWDECVRTAAADLAVLPSAGGYAAGPALYVALAR
                     GEAGAVERARALAGGAADWMATLVAAVVLTDAAALRGDAEEAVAQMRASLEALTGDTGG
                     RPDVAVRLAALALTPVADTAASARAGGDGATAARWSAVAEELMDLARAAAQRGEAGVPQ
                     GPEGQAWLARAEAERARAAGEPDAAAWEKAAAAFEFGDVYERARCRLRLAEALLAAGRR
                     EEAAGEARAARETAVRLRAAPLLERVDALIRRGRLAPAPPGRAGPAALTARERDVLRLL
                     GLGRSNRQIGEELFISGKTASVHVSNILAKLGASSRTEAVAVAHREGLLEPGAGASG"
     gene            complement(22578..22931)
                     /locus_tag="NFX46_RS15160"
                     /old_locus_tag="NFX46_15160"
     CDS             complement(22578..22931)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006133743.1"
                     /locus_tag="NFX46_RS15160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15160"
                     /product="UBP-type zinc finger domain-containing protein"
                     /protein_id="WP_252549588.1"
                     /transl_table=11
                     /translation="MTDTDAIDPSVPPTGTGCVECDATGGWWFHLRRCARCGHIGCCDS
                     SPAQHATAHWKATGHPLVQSFEPGEDWFWDYDSDELYESGPELAPPSGHPLGQPAPGPS
                     GRVPDDWARSLNR"
     gene            complement(22928..24415)
                     /locus_tag="NFX46_RS15165"
                     /old_locus_tag="NFX46_15165"
     CDS             complement(22928..24415)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015607238.1"
                     /locus_tag="NFX46_RS15165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15165"
                     /product="ATP-binding protein"
                     /protein_id="WP_252549591.1"
                     /transl_table=11
                     /translation="MSGRPMPCDAAEISTLFLFEKLSPEQLGRLCAEGRVERFEAGPVY
                     TEGDPATCFYVMIEGTVVLYRRVGADDVEVSRTSQRGVYAGAMQAYLGDRVPQVYNNSM
                     RVTEPTRFFVLPAESFSDIMREWFPMAAHLLEGLFFGSKNTQRAIGQRERLLALGSLSA
                     GLTHELNNPAAAAVRATATLRERVAKMRHKLAVISQGAYSREVLAKLIEIQERTAERVA
                     KAPVLSPLEASDREDELTDWLDDHGIQEGWRVAPTFVQAGLDVDWLEQVAAAVEADILP
                     NAIGWLNYTVETELLMDEIDDSTNRISHLVDAAKQYSQLDRAPYRVVDVHELLDSTLLM
                     LSGKIGQRIVVVKDYDRTLPDVPAYPAELNQVWTNLVDNAVFAINSIGGEGTLTVRTAR
                     EGDRLLVEFGDTGPGIPADIRSRIFDPFFTTKPVGEGTGLGLDISWRIVVNKHHGSLQV
                     ESAPGDTRFQVLLPLTAPEADADADPENASETTEEPV"
     gene            complement(24412..26088)
                     /locus_tag="NFX46_RS15170"
                     /old_locus_tag="NFX46_15170"
     CDS             complement(24412..26088)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010033203.1"
                     /locus_tag="NFX46_RS15170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_15170"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_252549593.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.5e-27, bitscore:
                     95.5, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQAAETARTVILTVDDDPGVSRAVARDLRRRYGGAYRIVRAESG
                     ESALGALRELKLRGDLVAVILADYRMPQMNGIEFLEQALDVYPGARRVLLTAYADTNAA
                     IDAINVVDLDHYLLKPWDPPEEKLYPVVDDLLAAWRASDHRPVPATKVVGHRWSARSSD
                     VREFLARNQVPYRWYSSDEPEGRRLLAAAGADGQRLPLVITPDGTPLIEPDAPELASHV
                     GLATTPEAEFYDLVVIGGGPAGLGAAVYGASEGLRTVLVERSATGGQAGQSSRIENYLG
                     FPDGVSGAQLTDRARRQAARFGAEILTAREVTGLEVCGPARVVRFSDGSAVAAHSVILA
                     TGVSYRQLLAPGCDDLTGCGVYYGSALTEAASCQGQDVYIVGGANSAGQAAMYLARGAK
                     SVTLLVRGESLTASMSHYLIQQIEEAPNISVRTRTVVEAAHGEEHLEQLTLRDVDSGAS
                     ELVDAQWMFVFIGAAPLTDWLDGTVLRDELGFILAGPDLTADGRPPAEWELDRPPYHLE
                     TNIPGVFVAGDARAESAKRVASAVGEGAMAVMLVHRYLEQS"
     misc_feature    complement(26149..26162)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.03"
                     /tool="antismash"
     misc_feature    complement(26395..26414)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.35"
                     /tool="antismash"
ORIGIN
        1 aggaggggat ggagtacccg gtcacccgct accggctcac ccagggcggg gtgttcgtgc
       61 tgctcaccga cggcgtcgtg gaagggccgt cgatgagcgt cgaggagggc ctggaccagg
      121 tggtgcgcct cgcgggcatc gccgcggtcg ccggcctgga ggcccatgcc ctcgccaccg
      181 ccgtgatgaa gggcgccgag cgcgtcgggc acgaggacga cgcggccgtc ctggtggtcg
      241 ggcacgatgg cacgcgcgcc gggtaggggg acgggcgggg ccttggtcga tgcggcggcc
      301 cgtgcggccg tagggccgag cggcaatcgt ggtcgtcggg cacgaggacg acgcggccgt
      361 cctggtggtc gggcatgagg acgacgcgac ggtgctggtc gtcgggcatg atggcacgcg
      421 cgccgggtag gggacggcgg ggcccgggtc gaggcggcgg cccctaccgc catgaggccg
      481 agcggccgtc ctggtctacg ggcacggccg ggtaggggac ggcggggccc gggtcgaggc
      541 ggcggcccct accgtcatga ggccgagcgt ccgtgctggt cgtctggcac ggccgggtag
      601 ggggcgggcg gggcccgggg cgaggcggcg ggcgcgtaca gcctgggccc gtacagccat
      661 ggggccgagc ggccgtcctg gtctacgggc acgtcggggc actgcgccac gcgcgccggt
      721 aggggaccgc agggccctgg tcgacacgcc tcgcgcgccg ggtaggggac cgcggggccc
      781 tggtcgaccc ggcaagcgcg ccgggtaggg gaccggcggg gccttggtcg atgcggtggc
      841 ccgttcagcc atagggccgg tacgtccgtc tcccgcctcg ccgtcggcac cgggccggtg
      901 tctgatggct gctgtggtgg gcaccagcga tctgcgtcgg ccggccgtcc tcgccgcgga
      961 gacggcggcg gtcgcggtcg gctactacgc ggccggaaag ctgggcctgc tgcgtcagct
     1021 cgtcgtcgag ggcgcgatct tcacccccat ctggccgccc tcgggcgtcg ccgtggcctg
     1081 tctgctgatc ctggggctcc gctgctgggc gggcatcgcc ctcggggcgc tgctcgtcat
     1141 cctgtcgctc acctcgctca gcccgtccgt cgtcttcaac ctggcgggca acaccgcagc
     1201 ccccgtctgc gcctacctca tgctgcgcag ggtgggcttc cgcaacgacc tcgcccgcct
     1261 acgcgacggt ctcgccctgg tgttcctcgg ggcgctgacc gcgatgctgc tcagctcgac
     1321 ggtgggcgtc ggtgtcctct tcatcaccga ccagttgccc gcacacgcct tctggcccgt
     1381 ctggctggcc tggtgggtcg gcgacgcgat gggcgtcctc atcgtcacgc ccgtcctgct
     1441 cgtcgtgcac gccgcccgcc ggcggccgcc cctgacccgc tggaaggagg ccgtgggcct
     1501 ggccgtcatc gccctcgcgc tcatccccct ggccaccaac agccacgtca gcctgctctt
     1561 cctcgtctac ccgctgctga tctggtcggc cctgcgcttc cagctcgccg gcagcatgct
     1621 gtgcgccctg gtcagctcgg tcctggccac cgtcgcggcc accgacgggg tgggcccctt
     1681 cgccgggctg acccgcgtcg aggtcatgag caaactccag gccttcaacg gcacgatggc
     1741 cctgaccgcc ctgctgctct cggccgtcat caccgaacag cgcaacacgc gccgctcggt
     1801 ggaacaggcc tgtcaggaac tggtcgaggt cctggagcac ctcaccgcag gtgaggcccc
     1861 gtacggcagg cccccgaagg acatggagga cggtccgccc ggcggcacat agggcctggc
     1921 cgatgctcgg cgcgcgacgg gtcggccggg tgactagcgt gaggaaccgg acacccgaca
     1981 gctctcaccg gaaagggcgg cgaccatggc cgtgcaaccc gagggaaccc cttgctgggc
     2041 cgacgcgatg ttcagtgacg tggagggggc caagcgcttc tacggtgacg tcctcggctg
     2101 gaccttcggc gagtcgtcgt cggagtacgg caactacacc caggcctacg cggacggcaa
     2161 ggcggtcgcc gccgtcgtac cgccgatgcc gggacaggag ggccagtccg cctggtgcct
     2221 ctatctcgcc gccgaggacg ccaccggcac cgcggcgagg atccgcgaga acggcggcga
     2281 ggtgctgatg gggccgatgc gcgttgggga gttcggcacc atgtgcctgg cccgcgaacc
     2341 cagtggcgcc gtgttcggcg tgtggcaggc aggcagccac gagggcttcg acgtgatggg
     2401 cgtgcccggc gcgtatgcct gggcggaggt cttcacccgc gagccggaga aggccgacac
     2461 cttcttctcc gccgtctacg ggtacggaca gaagcagatg gaggacgagg gcggcgactt
     2521 ccgcctctac gacctgggtg atgagcccgt cctcggccgg atggagatgg gcgacgactt
     2581 cccgcccgag gtcccgtcct acgtcaacgt ctacttcacc gtcccggact gcgacgaggc
     2641 cgtcgccaag gccaccgaac tgggcggccg gctctggttc ggcccgatgg gtacgccgtt
     2701 cggccggttc gccatcctca ccgacccgca gggtgcgaac ttctcggtga tcgacgtcac
     2761 caccaccgag ggcgagatgc cgcagaccag ggacgtctcc taggccgcgg agggcacacc
     2821 gccgggccat ggcatgatcg tgcgcatgcg tgaacgagtg gtggccgcgt gcgacggggc
     2881 ctcgaaggga aaccccggtc cggcgggctg ggcctgggtg atctccgacg cctccgaggc
     2941 cccggcccgc tgggaggcgg gtccgctcgg cagggccacc aacaacgtcg ccgaactcac
     3001 cgccctggaa cgcctgctgg cggccgtcga cgccgacgta ccgctggaga tccgcatgga
     3061 ctcgcagtac gccatgaagg ccgtcaccac ctggctgccc ggctggaagc gcaacggctg
     3121 gaagaccgcc gcgggcaagc cggtcgccaa ccaggagttg gtcgtgcgca tcgacgaact
     3181 gctcggcggc cgcacggtcg agttccgtta cgtgcccgcc caccaggtcg acggcgacag
     3241 gctgaacgac ttcgcggacc gggccgccag tcaggcggcg atcgtgcagg agccggcggg
     3301 cagcgccctc ggttcgcccg agccgccgcc ggcccccgac gtcccggcga aggccgccgt
     3361 acgccgcaag gccaacggcg ggaacggggc cggaggggcc accgggggca cttcggcccg
     3421 gcggcccggc ggttcgtccg cccgcacgat caaggccaag ttccccggcc gctgtgtgtg
     3481 cgggcgcccc tacgcgcagg gcgagccgat cgccaagaac gatcagggtt ggggccaccc
     3541 ggagtgccgt accacggccg ccgggtgacc tcggcccgta cggcagccgt acgggccgag
     3601 gcggcggcgc cggtcagacg accgcgccgc gccagccgcc ggtctcgagg ccgcgctcct
     3661 cgatgaactt cttgaagcgc tggagatcgc ccttggtctg ccgcttcacg aagccgagtt
     3721 tgtcgccgac ggtctcggcg aggccctccg gctcgaaggc catctggagc atcaccttcg
     3781 tgtgctcgtc gtcgagccgg tggaaggtca ccacgccgga ctgccgggcc tcgccgctca
     3841 ccgtcgtcca ggcgacccgc tcgtccggga tctgctcggt gatctccgcg tcgaactccc
     3901 ggtgcacccc gttcacgtcg gtgacccagt gggtgagtgt gtcggagcgc tgttcgacgc
     3961 gctccacccc gtccatgaac tcggggaacg tctcgaactg cgtccactgg ttgtaggcgg
     4021 tgtgcaccgg gacaccgacc tcgatggatt cctcgacctg cgtcacggtc ggtctcctcc
     4081 tcgttctcct cgggtacgtg gcacccgggt acccgaggcc tcgggggcca acccggcctc
     4141 gatcaggcgg tgtcgaaggt gtagtgcggg gtgtggtcga gcaggtcggc cggggtggtg
     4201 tcgttccacg gcttcatggt ctcgcgcagg tccaccacgt ccggcgtccc cgccgccggg
     4261 agatacccgg cctgcgggtg ccggcgctgc cactccgccc acaacttgtc tatgtaggcg
     4321 tggtgcagcc agaacaccgg gtcgttgggg gagaccccgg tggccatctg gccgccgacc
     4381 cagacatgca cccggttgtg caggttgacg ccccgccacc cctccaggtg gttgcggaaa
     4441 ccgtccgacc cgctgttcca cggcgccatg tcgtacgtcg gcatcgccag caccgagtcg
     4501 acctcggccc gcgtcggcag ctcacgcacg ccggttccga gcgcgcgccg cagaaacgtc
     4561 cgcccgtcga cccgcaccgt gatcggccag ttgccggagg aagcggcgaa cgggccgtcc
     4621 gtcacctgcc cgtcccggct gcgcccggtg ccgccgagga agtccggcgc ccacagcgag
     4681 gatcgcggcg accggtcgac ggaccagtcc cagtagggca gcgccaccga cgcgtccacc
     4741 gactggagcg cccgctcgaa ctccagcagg aatctgcggt gccagggcag gaaggacggt
     4801 gaacggtggc cggtgcgctc gccgttgtcg gtgtcgccga tgatgaacgc gttgtgcgtg
     4861 gtgacgaagg cgtcgtagcg gccgctgcgc ttgagttcga ggagggcggc gacgaaacgg
     4921 cgcttctcgt cggcggtcag ggacgcctgg ttcttgcgga cggtcatgtg tgtggtgctc
     4981 caagtgtgct tgctggccgg tcagttggtg gggaacggca gcagccgtgc gccctgcagt
     5041 tcgtcgaccg cggcgcgggc ggcggcccgc ggggacggca ccggggcgta gtgactgacc
     5101 acgctgatcc agctgccgtc ggcgttgcgc atcacgtgca gctccacgcc gtcgacgaac
     5161 accgcgtagc caccgccgtg gtgaccgccg ccgtggtgcc cgcccccggc agcgggccgg
     5221 ccctgtatcc ggcgtccctt gtagacctcg tcgaacgagc ccggggcgcc gggggagttg
     5281 ggggagtcgg acggggcggc gtgcgtggag tgcgccgcgg ccgtgccggt ggcggtggcg
     5341 gccgcggcga gggcggccgc ggtggtgagt gcgcgacgtc ggctgagttc cggcatgcgg
     5401 gacctcctgg gggtgcgttc ggttgacgac cccgcatgcc tatccgccga ccggagggcg
     5461 ggagaaatcc cacggaacgg gttggctgcg atccggacaa tcgataacaa gtcgtgcaat
     5521 cttaaatgaa gatgatcttg ctctccggtg cgggccccgt cgagcggaac gggcaattcc
     5581 ttgccctgga aggggccctt tcggtgatct ctggcgggcg gcggctccgc cagtggtgtg
     5641 gctcacgtgc agaaagtgac ggaatcacga agaagggccc cctgtgacca cccccgcccg
     5701 ctgctactgt gcgtcgtcaa tcagccacag ttcgtcattc ttgggggtgt gcgtgaaggt
     5761 cgcctgcgtc ggcggcgggc ccgccggcct gtatctctcc atcctgctca agcggcagga
     5821 cccgtcccac gacatcaccg tccacgagcg cgacccggag ggctcgacct acggctgggg
     5881 cgtcacgtac tggcgcggcc tcctcgacga actccacgcc cgcgaccccg agtcggcgcg
     5941 cgccgtggag gagcactcgg tgcgctggaa ccagggggtc gcgcacgtac gggacctggt
     6001 gacccgtcag cccggcgacg cgggccacgg catcggccgc cacaagctgc tggagatcct
     6061 caccgcccgc gcccgcgcac tgggcgtacg cctggagttc gagcgcgaga tcacgcccga
     6121 cgacctgccc gaggcggacc tggtcgtcgc ggccgacggc gtgcacagcg ccctgcgcac
     6181 ccgtcacgcc cagcacttcg gcgccgcgct cacgcccggc cgcaacccct acgtctggct
     6241 cggcaccacc aaggtcttcg actccttcac cttcgccttc gtggagaccg gccacggctg
     6301 gatctggtgc tacggctatc cgttcagcgc cgatcggagc acctgcgtca tcgaatgtgc
     6361 tcccgaaacc cggaccggcc tcggcctcga ccgggcgaac gacgcggacg gaacggcacg
     6421 gttggaggga ctcttcgcgc acatcctcga cggccacccc ctgatcggcc gcgcctccgg
     6481 cgacggcggc gccccctggc tgaccttccg caccctcacc aaccgcacct ggtaccggga
     6541 caacgtcgtc ctcctcggcg acgccgccca caccacccac tactccatcg gcgccggcac
     6601 caccctcgcc ctggaggacg ccttcgccct cgccgacgcc ctgcgggagt gccccgtcct
     6661 gccgcaggcc ctcgcccgct acgagcgcga ccgtacggcg gccctgctga ccccgcagag
     6721 cgccgcccgc cacagcgccc agtggtacga gaacctcgcc cgctacatcg acctgccgcc
     6781 ggagcagatg ttcgccctgc tcgggcagcg ccactcgccc ctgctgccgt acgtcccgcc
     6841 ccagctgtac taccggctcg acaaggccgc cgggcggctg gagaccctgc gcaggctcaa
     6901 gcgctggctc ggaccgaggc tcgccaggac cgcgcagacc gcacagaccg cgagaaccgc
     6961 gcaggccggg accgcggcct cccggaagta gcggaccgcc cggccgagcg gggaagggcc
     7021 cgcaccgagg agatcgccga ccgccgcggc cacggtgcgg tcggatccga ccggccggcc
     7081 gccgcgtgga cgaaccgcag gtggcgggcc ggaccgggcg gttccgcgcc cggccggaac
     7141 gatgacagac tgcccccatg gacgagcgcg aattcggcag gtctggtcag cacgcatccg
     7201 tcatcggtct cggcacctgg caactgggcg ccgactgggg cgacgtcgac gacaaggagg
     7261 cgctggcggt gctggaggcg gccgccgagt cgggcgtcac cttcttcgac accgccgacg
     7321 tgtacggcga cggccgcagc gagcagacca tcgccacctt cctcggcgga cggcccgacc
     7381 tgcatgtgct ggtcgccacg aagatgggcc gccgcgtgga ccagatcccc gagaactacg
     7441 ttctcgacaa cttccgcgcc tggaacgacc gctcccgccg caacctcggc gtcgaccgca
     7501 tcgacctcgt gcagctgcac tgcccgccca cctccgtgta ctccacggac gaggtcttcg
     7561 acgccctcga caccctggtg gaggaggagc gcatcgccca ctacggcgtc agcgtggaga
     7621 cctgcgccga ggccctcacg gcgatcgccc ggccgggcgt ggccagcgtg cagatcatcc
     7681 tgaacccgtt ccgcatgaag ccgctgtacg aggtcctccc ggcggcccgc gaggccggcg
     7741 tcggcatcat cgcgcgcgtt ccgctcgcct ccggcctgct gtccggcaag tacaccaagg
     7801 acaccgtctt cccggagaac gaccaccgca cctacaaccg gcacggcgag tccttcgacc
     7861 agggcgagac gttctccggc gtcgactacg ccaccggcgt cgaggccgcc gccgagttct
     7921 ccgccctcgc ccccgagggc tgcaccccgg cccagctggc gctgcgctgg atcgtccagc
     7981 agcccggcgt gaccacggtc atccccggcg cccgctcgcc cgagcaggcc cgcgccaacg
     8041 ccgccgccgc ccgcctgccc gagctgtccg aggagaccct ggccgcgatc cgggacctct
     8101 acgagcgacg gatcaaggac caggtcgaga gccgctggta gtcccgcccg cgatcaggcg
     8161 gaggaaaacg ccgatcagcg ggtacacgcc ggtgagaaca cttactcgaa ccggggagga
     8221 cacgtggcca ccgcagtggg ggacgagcgt cgcagaggtc gcaacgagac cgaggaggag
     8281 cgggccgacc ggatgtgggg ggagctgatc caggaggtcc gcgtcgccca gacaggcgtc
     8341 cagatcctct tcggcttcct gctcacggtc gtcttcaccc cgcgctacgc gagcctcgag
     8401 gacgtcgacc gggccatcta catcgtcacg gtggtgctgg gcgcctgcgc gacgggcgcc
     8461 ctcatcggcc cggtctccct gcaccggctg gtctccgggc ggcgggtgaa gtcgcaggcg
     8521 gtcacctggg cctcccggat gacgttcgtc gggctgatgc tgctgctcgc cacgatgacc
     8581 tcggcactgc tgctgatact gagggtggcc acccacgacg gctatgtgcc gtacctggtg
     8641 accggggtgc tcgtgtggta cctggttttc tggttcgggg ttcccctgtg gacccggcac
     8701 cgctactcgt cccgctgaga ggttcacttc ccgcggcggc gggcgggcgg gccactggtt
     8761 cggccgcccg tccgccgtcc gcgcgcacgg ctcagtcggt ggcgcgggcc ccgcgcaggg
     8821 ccgcgatgca gccgccgatc gcctgctgga gttcctccag ctgcttgacc atgtcgtcct
     8881 cgtagaagtc ctgcgcgtcg tcgaaggtca gctcctcgaa caccttcgtc gccttctgga
     8941 gaccgctgta gaacttcgtg cgccgctcct gcacccgcag ctcggggtcg gcctccacgg
     9001 cctccacgac gagggtcttc agcgtgtcgt acgcctccgt cgcccactca ccggagtcct
     9061 cgccctcatc cagctcgtcg agcagggaca ggtgccgctc ggcctcctgg cgcaggtcgg
     9121 cgggcgcgtc cacggtctgc ccggcgggcg tcttgatccg acccgactcg gcgatctgac
     9181 ggacgtaccc gatccggtcc gcggagcggc tctcgctggc gacggccttc ttgaggtcgt
     9241 cggtgcgcac cacgtcccgc gccagctcgc tctgcagctc cgggtcctcc ttgatgcggt
     9301 ccaggagcgc ggcacgcgcc gcccgcgcgg tcgacgggtc ggcgaggatc gccgcgcgca
     9361 gggccgtcgg gttctcggcc acctccagcg ccttggtcgg ccggatgccc tcggcctcgg
     9421 cggcctcggc gatcgcggtg ccgcgctcgg aggaggcgct ggagcgcgac acgtagtagg
     9481 tcagccagac gtcggcgtcc ggcagctcga cctcctgtcc cggcgccagt tcctcgaagt
     9541 gcgggacgag accgtcgtcg gcggcccggt cccaggcctt gtagtgacgc atgacgcgct
     9601 ccgcggagca gccggccagt tcggcgaact ccttcgccga caccttcggc gtctcctgcg
     9661 cgctctgccc gcccggccgg acgctgcgcg ccaccatcag cccgaaggcc cagccaccgg
     9721 tccgcgcgta cacgccgaac tcgcgggcgt cgcgcgccac gaggtcggac agcggagcgg
     9781 gggacgccgc cgcggcggac gtctcggacg ggtcgatcgc tacggtcacg gatgactctc
     9841 ctgtgcagaa ctgcgggaac cgcacgcccc ggaacgggat gcgcggttcc cgcagcctag
     9901 gacaggcacg ggcgccgccc gtacccgtca cgccggtggg gggccggcgg ggagtcaggc
     9961 gaacgcgtcg cgcagggcgg gcagcagcgt cttctccgac cagtccaagt acgccggctg
    10021 cgtgtcgccc ccgatctgca ccagggcgat ctccgtgaag ccggcctccg cgtacggacg
    10081 gaccgcctcg acgaaggcgt ccggatcgtc gccgcacggg atggacgcgg ccacgtcgtc
    10141 cggggtgacg aactgggtcg ccgactcgaa ggagtccgga tgcggcagct cggcgttcac
    10201 cttccagccg ttgccgaacc agcggaactg ggcgtgcgcc cgtttcaccg ccgtgtcccg
    10261 gtcggggtcg taggagaccg gcagctggcc cacgcgcggc ttgcccgcac cgccgtgccg
    10321 gtcgaaggcg tccagcagcc cggccttcgg ctcggtggcg atcaccaggt cggcgaggcg
    10381 ccccgcgagc gcgcaggact gctccccgga gacggcgatg ccgatctcgg gcggcacgtc
    10441 gggcaggtcc cacaaccggg ccgagtcgac gtcgaagtgt gtgccgtgat gcgtcacgtg
    10501 gccgccctcg aagagcgccc ggatgatctc cacggcctcc tcgagcatct cgtgccgcac
    10561 gtccacggcc ggccagccac cgcccaccac gtgctcgttg aggttctccc cggagccgag
    10621 ccccagccgg aagcgcccct cggacagcag ctgcatggtg gcggccttct gcgccacgat
    10681 tgccgggtgg tagcggaccg tcgggcaggt cacgtacgtc atcagcggaa tgcgtgaggt
    10741 ggcctgggcg gcggcgccaa gcacgctcca cgcgtagggg gagtggccct gtgaccgcag
    10801 ccacggaaag tagtggtccg aggtcaccga gaagtcgaaa ccggcctcct cggcccgcac
    10861 cacgtggtcg accaggtcac gagggccggc ctgttcggtc atcatcgtgt atccgattcg
    10921 caccatgtgt gacgggtccc cgggcaacgg gcggggaaac cggccacggg cgggaccgga
    10981 aaaagcccgg acctccctcg ccgtccgccc ggcgttcggg gaaggatgcg gacatgagcg
    11041 cccgtccact gcctgacagc accccgtccg cccagggcgt cgacgcctcg ggcgtcctcg
    11101 ccttcctcga cgccgtcgac gcggccggga ccatcgagcc gcacagcctc atggtcctgc
    11161 ggcacgacca tgtcgtcgcc gccggctggt gggcgccgta cacgcccgac cgcctccacc
    11221 tgctgtactc cctcagcaag agcttcacct cgacggccgc cgggttcgcc gtcgccgagg
    11281 ggctgatcgg gctggacgac ccggtgatct cgtacttccc ggagttcgac gccgacatca
    11341 ccgacccgcg cagccgcgcg atgcgggtgc ggcacgtggc gtcgatggcg agcggacacg
    11401 aggccgagac cctggaccgg gcccgcgcgc tcgaccgcga cgacctcgtc cgcggcttcc
    11461 tgctgctgcc gccggaccgc gatccgggca cggtgttcgc ctacaaccag cccgccacct
    11521 acaccctcgc cgcgatcgtc cagcgcgtca ccggtcagtc cctcaccgcc tacctacggc
    11581 cccggttgct ggacccgctc ggtttcggcg aggtcgcctg gctgaccgac cggaccggcc
    11641 gcgagctggg cttcagcggc ctgcacggca ccaccgacgc gatcgcccgg ctgggccggc
    11701 tgtacctgcg cgaaggcgac gcggacgggc ggcggctgct gccgcgggag tggatcgcgc
    11761 aggcgacccg cgagcacatc ccgacggcgg gcgccatggg cgacaccgac cggcaggact
    11821 gggaccgcgg gtacggcttc cagttctggc gctcccggca cggctaccgc ggcgacggag
    11881 cctacggcca gttctgcctc gtcctgcccg agcacgacgc cgtcatcgcc acgaccgcgg
    11941 cgacccccga catgcacggc ctgctgaacc tcgtctggga gcacctcctg ccggcgttcc
    12001 gcccggcccc gctgtccggt cgccaggacg ccgacgcggc cctcgccgac cgcctcaccc
    12061 gcctcgccct cccgcccgcc ccgggcaagc ccgtcccgcc ggaccgcccg cgcgcatggt
    12121 cgggggccgc cttcaccccg tacggcggtg tctgcgccga ccagccgagc ctcaccggcg
    12181 tgcgcgtcac ggcggacggg gacggttgga cactgaccct cgccgagggc gatgagcgcc
    12241 tcgcaccgcg tctgggcccc ggcggctgga ccgtgaccga ggaacccgtg cccgtcgcgg
    12301 cgagcggcgg ctggagcgac ggcgacaccc tcgccgtgga cctggccttc ctggagaccc
    12361 cgcaccggct ccgggtgacc tgctccctcc ctgccaggac cttcaccgcc cgctgggcca
    12421 cacagcccct gcacggcggc accctgcaca tgcggtgcgc gccgcggtcc taggccccgg
    12481 ccggcgtccg gcgctccttc gttccggacg accggcggcc cggttcgccg gtccggttcg
    12541 ccggcctccg agggggacgg ctcaggccga gcccggccgg aaggtgctca ggaaggtgtc
    12601 cagggcccgg ccgttggcgg cttcgtccca gtcggccgcg ggggtcgtcc agcgcaggga
    12661 gaagccccgg tggtcgccga ggaggaagcc gcggccgaag gtgcgtaccc gggtgccgtc
    12721 gacgtcgacg acccattcca tgtcggccgc ctcgtacccc cggtacgtcg tcgcctcgat
    12781 cgccccgatg cgcgcgaacc cgtcggcccg gcgcaggccc ggctccacgt cgtcgcgcca
    12841 gaccgccacc gggtccgggc cgacgcgttc gctgtaggtg accgcgaggg tgcgcgggtc
    12901 gccctcggcg ccgaacgtga cccggtaggc gaggtccccg gtgcgcgtgg tgtccagccg
    12961 ggtccagtcc tcggggaggg cgacggagaa gccctcctgc gcccggaaca cccggaagcc
    13021 ggccggcagg gccccggcgg tggccgacgg ggaggcggca gtgggagtcg gggccgaggt
    13081 cggggtgggg ccggcggagg ccgcgggcgg tgaggacgcg gccggcgggc tcggagccgg
    13141 cgtcggcacg tccgtgactt cgtcggcgcg gtcctcgccc ggcggggcgc tgggcgcggt
    13201 cgggcgggtc cgcgcgctgt ccgacgacgt gctctcggtc ccgggcaact ggcccgtcgc
    13261 ggccaggacg gcgaccgtca tggcgatcac ggccagcgcg gtcccgcccg ccacggcccg
    13321 cccgttccac cccggaccgg cgacccgctc gacggcgtac gcgcgccgca gtcggggctc
    13381 gggcaccccg tgcgtgtcct cgtccaggac gcgggcgagg ctgtggcgca ccgccggccg
    13441 ggtcatccgc tcccgcgagt ccttgcgcag caggccctgg atggcgggtc ctagcggacc
    13501 ggcccgcagc ggagtgcgca acggcagccg gtccacgccc ttcagcgtgg cctccggccg
    13561 gtcccggtcc cggtacggcg gccggccctc gaccatcgtg tagaggatcg cgcccaccgc
    13621 ccacagatcc gccgcaggcc cgatccgctc gtcccgcgcc tgctcggggg aggcgtacga
    13681 cggggccgcg aggcggggag ccagggccac gcccgcgagg ccgaagccgg tgacgacgac
    13741 cgggccgtgt gcccgcacga acacctgacc ggggctcagc tcgccgtggg tgatgccctg
    13801 gccgtgcgcg acctccagca cgtcgagcag ctccagcccg atgcgcgcgg cgcgggcgtg
    13861 cgggaacacg cgccgctgct cgatcagttg gcccaggggg aggccgtcga tccactcggt
    13921 cacggtccac agggaccccg cctcagcgag ggcgtcgagg accgtggcga cccggccggg
    13981 gcagacccgg gccatcgtct cggacatccg tacgacgcgc tcggcggccc ggtgcgcgtc
    14041 ctcctcgccg aggcccgtgg gcagcccgat ccgggtgatc agacacgggc gggtgccggc
    14101 cgagtcgtcg gcgtactcgc cgtaccagcc gacgcggttc gtctcgcggt ggacgacgtc
    14161 gaggagccgg taccgaccgg cgaccaactc gtgctcggag acgtgcgcct tgaccatggt
    14221 catccctcgc tgaaaccccg gctgctcacc tttcccagtg gtacggcgat cgagagggtg
    14281 tgcgttcaag agatccgcaa ctccgccgtg atttctgtct ttcattcaaa aacggcggcg
    14341 agaaagccga tcaaatgtac gaggaaagga aattgcttcg ggccgtccag gggtgtaacc
    14401 agcggtaaac ggctgccggg cggccacgga atcgcccgcg acgggcgtcg gtccattcca
    14461 ggactacggc cgccgcgggc gttttcctcg gccccgcgca caccgaaacg tcagcgcagt
    14521 ccgaaacgct cgacccagga cgccatgtcc acggccgacg cgttgccccc gcagaccacc
    14581 agccccagcc gggcgtccgg gcccacccgc tccacgaccc gccgggcggc cggcagcaga
    14641 catccggcgg ccggctcggt ccacaccttg gcgtgctcgg ccagctccag gcagccccgt
    14701 acggcctccc ggtccggcac cacgagcacc tcgcccacca acgccgcgac atgctcgtac
    14761 gtcagcggtg cgacggccgg cgcgctcagc gtggtggaga tggacgacac ctccaccggc
    14821 accgggccgc cggccttgag cgcctccgcc atcgcctccg cgccctcggt ctccacaccc
    14881 cagatccgca cctgcggccg tagcgcccgc agggccgtgg cgacgccgga gatcagcccg
    14941 ccgcccccga cgctgaccag gacgtccgtc agctcgtcgg cgtcccgcgc gaactccagg
    15001 ccgaccgtgc cctgcccggc gatcaccacc gggtcgtcga acgggtggac cagcgtcagc
    15061 ccttcgtccc gcaggtcgtt cacgagcgag aaggcactgc ccatcccgtc cgtcagccgc
    15121 accgacgcgc ccgcctcctc ggcgatctcg atggcacggg cgggcgccga acgcggcatc
    15181 acgaccgtgg ccttcacgtc gagggcggcg gccatgaccg ccaccgcgat cccgtggttg
    15241 ccgccgctca ccgccaccac cccggccgcg cgctccgcct cgccgagcga gagcagtttc
    15301 gccgccgccc cgcgcgcctt gaaggagccg gtccgctgga gcagctccag cttcacggtg
    15361 acggggacgc cgagcagccc ggagagtccg ggactcggga gggtcggggt gcggacgacg
    15421 tgcccggcga tccgctccgc cgcggcttcg atgtccgtga tgccgatcaa gacgaccacc
    15481 tttcccgcgc gctgtgccgc gcgctctccg caccctgtcg cgcgtcggtg gcccaggtca
    15541 accgggtccg ggcggtggtc agaggtcgcg ccgcaccagg aagtcgagca gcgaccgcag
    15601 gtcgcccgcg gcccgcgtcc gcagcggcac cccggcgagc gccgactcca cggcggacac
    15661 ctgccggcgc gcctcggcga gcgccgccgt ccggcccccg gcctcctcgg ccagtacggc
    15721 cgcctcggcc gggtcgcccc ccgactccag cagccgggcg aggcgtcggg ccgccggtgc
    15781 gggggactcc agtgccgcca gcaccgggaa cgtcttcctg cccgcgcgca ggtcgccgtg
    15841 gacgggcttg ccggtcacgg ccggatcgcc ccagatcccc agcaggtcgt cgaccacctg
    15901 gaaggcgatc cccagatgcc gcccggcccg gtccagggcg atgacggtcg cctccggggc
    15961 accaccgagc acggcgccca gcgcgacggc gcagcccagc agcgagccgg tcttgccctc
    16021 ggccatcgcc cggtacgcct ccggccgcac ccgctcgggc cccgaccagg gccgcgcggc
    16081 gaacagcagg tcgtcggcct gcccgtgcac cagctcggcg agcgccccgg acagcagccg
    16141 tacgccgccc gcgccgcccg gggccgcggc gagcgtctcc acggccagcg cgaacagggc
    16201 gtcgcccgcg aggaccgcgg gtcccgtgcc gtaggccttc cagacggtgg ggcggctcct
    16261 tcgcgtggga tcgccgtcca tgatgtcgtc gtgcagcagg gagaaggtgt gcacgagctc
    16321 gacggagacg gccgcggcga caccggcccg tgcgggcgcc cccgccgcct ccgcgccgag
    16381 cacggcgagg gcctgccgca gccccttccc accggacgcg gcggcagggg ctccgccgac
    16441 ctcgcaccag ccgagggagt acgcggccat ctcgcccacc cacggatgca gccggccgac
    16501 cgcctcggcc agcgcgggcc gcaccagtgc gcggcagcgg tcgagaacgg ccggcgcgac
    16561 cggtggagtc ggacgcaccg ccggggccgc gacggggtcc gccgcggccg gggggaaccc
    16621 cgtggagaac gtggtggaca gggccgtcac cgtacggcct ccgcggtcac gcagcgcggc
    16681 ccggccgggt ccgtcccgat gcccagttcc tgttcggccc ggtccaccat ctcccgcgcg
    16741 tgccgcagcc cgatccgctc caactcaccg gccagggccg tcagttcctt ggccgtctcg
    16801 gagcggtcgc gccccaggcg ggccagcgac ttggcgagcc cgagccgggc gagggccttc
    16861 ccgcgcggct cgctcatcgc gccgaactcg gcgagggccc gttcgtagag gtcccgggcc
    16921 tcggcgtaac gggctgcgcg gtacaggacg ttgccgcgca tcttgtggtt gtaggccagc
    16981 gctccggtga ggttcatcgc acggcaggtc gtctccgcct cggacagcag cgcgagggcg
    17041 cgctcggtgt cgccgtcccg tatcgagacc acgtcggcca ggccgcgcag cgcccaggcg
    17101 tgtccccgcc ggtcgtcggc gcgcgccgag atctcggccg cctcctcgaa cagggcgtga
    17161 gcggtgtcga gatccccgga gttgcggtgc atctgtgcga tgccctccag cgcccacacc
    17221 gtgtgccgcg cctcgccgcg ccggcgggcc tcggcgagca gttgctcgtg cagccgaccg
    17281 acggcctcgt agtccccctg gatacggccg gtctccgcca gcccggccag cgagtacccg
    17341 cggacgacga cgtccccgcc gcgctcgccg aggtcggccg ccagccccag cagccgtcgg
    17401 gccagcggga aggcgccccg ctgccgggcc agtgtgccgc cgctccacag ggcccacgcc
    17461 atcgccgcca cgtcgcccgc gtcccgggcc gcgcgatagc tcgccttcca ggccaggtcc
    17521 gcctcccgca cctggcccag ccgacggtgg gcctcggcga cggcgagccc ggagcgggcc
    17581 acctcggcgc gctccccggc ccgctcggcg gccgccaacc gctcggtgcc ggcggccagt
    17641 acgtcgacca gtgaggagtt cacggacagg gtggtgaggg cgccctgata ctcgggggcg
    17701 gaagccttgc cgtacatcga ttcctttcgg ccaccatgta tacgctgcgt gtatacatgg
    17761 cgcgtatagt gcgcccgaaa tgtgccccgg ccgtggggtg gccggggcgg gcgtcaccgg
    17821 atgctgtgtg gtgtcgccgg tcaagacgtg cgtacggcgg gccgggttgc ctgtgaggcg
    17881 cagatcactc ggcgggccga agcgggcggg cgtgggccat cgggcgtcag gcgccgaaga
    17941 gttgggtcca gtacgtcccg gacggaccgc cgcccgcgaa gccgacgccg atgtgggtga
    18001 aggcgggctt gaggatgttg gcgcggtggc cggggctgtt catccagcct tccaccacct
    18061 cggccgggga gcgctggccg caggcgatgt tctcgccgat cgtccgccgc gccgaacccg
    18121 cggctgcggc gcggtcccac ggccggccgc cctcgggcga ggtgtgcgag tagaaggaac
    18181 gggcgaccat gtccgcgctg tgcgcccggg cggcggtggc gagcagcgga tcgacggcga
    18241 gcggccgcag tcccgcccgc gcccgctccc ggttggtgcg gtcgacgacc tccgcctcgg
    18301 tccccgccag cccggccggt gtcagcgggc tcgcccacag ggccgtccac aggacgtcac
    18361 cggtgcggcc gtcctccgcc cgggccaggc cggcgtgggt gaacgccgga tcgtgcaggg
    18421 tacgccgggc ctggtcggtg cgcaggcagt acccgaggaa ctcggccgac gtgcggggcc
    18481 cggagaccag gtgttcgccc acggcgaggt agcggaagcc ggcggccgtg acgcgctggt
    18541 ggacggagac gccgtcggcg cccatggtgc ccagccggcc ggccgcagtc atcgcggtga
    18601 cgtgtgcgcg agccgccgag accagccggg cgtccagcga gacgggcggt gaaccgaccg
    18661 cggcacgggc ggagttgacc ggcccgagaa acctctccgg atcgggggcg cgaacggacg
    18721 cgggcgccgg cgcggcagcg gttcggggcg cgggagaccc ctgggcagcg gtcccttcgt
    18781 cggcgacctc caccccgaag tcccgggcca gcccggccag tccgtccgcg tacccctgcc
    18841 ccagcgcccg cagcttccag acgccgccgc gccggtacac ctccgcgagc agcaaaaccg
    18901 tctcctgccg ggcgggcgcg ggtgtgaacc gggcgagcgg acggccctgc cggtcggtga
    18961 cctggagcgt gggcgcgggc agtccgcccg gccgggtgcc cggctcgacc gcgctgacga
    19021 ccaccgtgac ccgggtcgcc ccggcccgca gccgcgccgg ctccagcgtg agcgtgccgc
    19081 cccgcagccc ggctcccggc gccgtcggct ggttgtagaa cacgaagtcg ccgtccccgc
    19141 cgaccttgcc gctgtcgtcc gtgaccagcg cgcacacatc gaaggggccc gacacccgga
    19201 cggccagggc accttccggc agggccacat tggccccggc aaccaactcg ctcatcccgc
    19261 cgccccgctg tcccggcccg accctcacgg agccttgcgg ggagaacgga cggcggggcg
    19321 gaggcgttcc ccgggggccc gacctcagcc cgaggccccc gcccccggct ccagcagccc
    19381 ctcccgatgg gcgacagcca ccgcctccgt acggctggac gcgcccagtt tcgccaggat
    19441 gttggagacg tggacactgg ccgtctttcc gctgatgaac agttcctcgc cgatctgacg
    19501 gttgctgcgg cccaggccga gcaggcgcag gacgtcccgc tcacgggccg tgagggccgc
    19561 cggtcccgcc cggccgggcg gcgcgggcgc gagccggccg cgccggatca gggcgtccac
    19621 ccgctccagc agcggcgccg cccgcagccg tacggccgtc tcccgggcgg cgcgggcctc
    19681 gccggccgcc tcctcgcgcc ggccggcggc caacagggcc tccgccagcc gcagtcggca
    19741 ccgcgcccgc tcgtacacgt ccccgaactc gaaggctgcc gccgccttct cccaggccgc
    19801 cgcgtccggc tcgccggccg cacgcgcccg ctcggcctcg gcgcgggcca gccaggcctg
    19861 cccctccgga ccctgcggca ccccggcctc gccgcgctgc gccgccgccc gtgccaggtc
    19921 catgagttcc tccgcgaccg ccgaccagcg ggcagccgta gccccgtcgc cgccggcgcg
    19981 ggccgaggcg gccgtgtcgg ccaccggcgt cagcgccagc gcggcgagcc ggacggcgac
    20041 gtccgggcgg ccgcccgtgt cgcctgtgag cgcctccagg gaggcacgca tctgtgccac
    20101 cgcctcctcg gcgtcacccc gcagggccgc cgcgtcggtc aggacgacgg cggcgaccag
    20161 cgtcgccatc cagtcggcgg cgccccccgc cagggcccgc gcccgttcga cggcccccgc
    20221 ctccccgcgg gccagcgcga cgtacagtgc gggcccggcc gcgtacccgc ccgccgaggg
    20281 caggaccgcc aggtcggccg ccgccgtccg cacgcactcg tcccagcggc ccagcgtgtg
    20341 gagcagcagc agttgcagat agcgcatctc cagcggatac ggcgaggaga gcaggcccgc
    20401 ccggcgggcc cggtccaggc cgtcggccag ccagggcagg cactcctcga actcccctgc
    20461 ctcgtaacac ccgatggcca ggttgaacag ggcccgcatc tccaccgggg cgctgcccgc
    20521 ccgccgggcc agctcccggg cctcccgcag gcgctcgcgg ccctcggggg agcgccggcc
    20581 gccaccctcc aggacggcga gcgagatcag caggtcggcc tgcgcgtcgg tcaccttcaa
    20641 ctggtccgcg acggccagcg cctggcgggc gacccgccgc gcggtctccg tctccccgac
    20701 ctgacgggcc gccaggacat gggtggccgc ggcccacacc cacgtcgggg acggcggctc
    20761 ggcggggatc atggccagcg cctcgctgct gtagcggaac gccgccgtga gactgtcgac
    20821 gccgaggagg gtcccggcca gcgtgtaccg cacgcgcgcg gcgagttcgg agtcggcgtc
    20881 ctggcccacc ccggcgagcg cggcgcgcgt cagggagacc gcgcggtgcc cctgcccggc
    20941 gtgcgcggca gccgccgagg cgcgcagcat gagcgtgacc cggtccatgc cctcgcccga
    21001 cgggcgggcg gaggcgtcca cggtgggcca caggtcgagc gcggtctcca gctggcgcag
    21061 ttcctcggcg ggcgccccca cccgctgggc gtggtcggcg gcctccaggg aggcggtgag
    21121 cgcctccggc aggtcatggc tctcgcggta gtggtgggcc cgctcggcgg cggtctcggc
    21181 gcggtgcccc cggccgccga gcagccgggc gaacgctccg tgcagccggg cccgttcccc
    21241 cgggaggaga tcggcgtaca ccgcctcgcg cgcgagcgcg tgccggaagg cgtacgtgtc
    21301 gcccgcgccc gcgacgagga gctgtcggcc tatcgcctcg cgcagcgccg actccagctc
    21361 gtcctcgggc agcgcgaccg cgtcccgcag caggtcgtgc tccacccgcc gcccggccac
    21421 ggccgcggtc cgcagcacca gttgggcggt ctccgagagc tgctccacgc ggatcatcag
    21481 caggtcggcc agtccgctcg gcaccccacc cgccccggtg tccgtcgcgg cgagcaactc
    21541 ctccgcgtag aaggcgttgc cctcggcgcg ctccacgatg cggcgcaccg tggtgtccgg
    21601 cagcggacgg tcctccaggg cgcgcaccag ccgggtcacc tcggcgtccg ccaggggccg
    21661 cagctccagc cgctccacgc ccggcagccg taccagctcg gccagcagcg gccgcagcgg
    21721 atgccggcgg tgcagatcgt ccgcgcggta ggaggtcagc agcgcgagcc ggtgggcggg
    21781 cgcaccgccc gcgggccgct ggaggacgcc ccggctcagc aggaaccgca gcaggtcccg
    21841 ggaggattcg tcggcccagt gcaggtcttc cagcacgatc aggagcgggt tgacctccgc
    21901 caggtcggcg agcaggcccg ccatcccctc gaacagccgc agccgcccgc ccaggtcccg
    21961 tacggcgtcg tccggcccgc cgccgagcag ccggtcgacg acgggatgcc cggcgaggac
    22021 ggccgcgaag cgctcgtccc cggcgagcgc accgaggatc tccgtgaacg gcagataggg
    22081 caggcccacg tcaccgagat cgacgcagtg cccggtcagt acggtcgtcc cggtgcgcgc
    22141 ggcccgcgcc gcgatctcgt ccagcacgcg cgtcttgccg acgccggcgt ccccggcgac
    22201 cagcaccgcc cgcgcctccc cggcacgggc gcgctccagc acgccggaga gccgggcgat
    22261 ttcctcgtcc cggccgatga acacggtggc gaacgctgtg ggaggcacgc ctccatcctg
    22321 gcatgcgcca ccgacaactc cgcccgtgag cagggcggac cccacagccg cggcgccgca
    22381 gaggctgagc ggatccgcgg atcggtgcct ccgtgcctct atggctccgc gcctccgcgc
    22441 ctccgcggct cggcggctcc gtggctcagc ggctccgtgc ctcggcggct ccgcggctcc
    22501 gcggctccgc gcctccgcgg ctcagcgcct cagcgcctca gcgcctcagc gcctcagcgc
    22561 ctccgcgcct cagcggctca acggttgagc gaccgggccc agtcgtccgg cacccgtccc
    22621 gaagggccgg gcgcgggctg gcccagcggg tggccggacg gcggcgccag ctccgggccc
    22681 gactcgtaca gctcgtcgct gtcgtagtcc cagaaccagt cctcgccggg ctcgaagctc
    22741 tgcacgaggg gatgcccggt ggccttccag tgcgcggtgg cgtgctgggc gggggaggag
    22801 tcgcagcagc cgatgtggcc gcatcgggcg cagcgccgca ggtggaacca ccagccgccc
    22861 gtcgcgtcgc actcgacgca gccggtgccg gtgggcggga cgctcgggtc gatggcgtcg
    22921 gtgtcggtca tacgggctcc tcggtggtct cggacgcgtt ctcggggtcg gcatcggcat
    22981 cggcttcggg cgcggtcagc ggcagcagca cctggaagcg ggtgtcgccc ggcgcggact
    23041 cgacctggag gctgccgtgg tgcttgttga cgacgatccg ccaggagatg tccagaccca
    23101 ggccggtgcc ctcgccgacc ggcttggtgg tgaagaaggg gtcgaagatc cggctgcgga
    23161 tgtccgccgg gatgccgggc ccggtgtcgc cgaactccac cagcagccgg tcgccctccc
    23221 gggcggtccg cacggtcaac gtgccctccc cgccgatgct gttgatggcg aacaccgcgt
    23281 tgtcgacgag gttcgtccac acctggttca gctccgccgg gtacgcgggg acgtccggca
    23341 gtgtgcggtc gtagtccttg acgaccacga tgcgctgccc gatcttcccg gagagcatca
    23401 gcagggtgct gtcgaggagt tcatggacgt cgacgacccg gtagggggcg cggtcgagct
    23461 gggagtactg cttggccgcg tcgacgagat gggagatccg gttggtggag tcgtcgatct
    23521 cgtccatcaa cagctcggtc tcgaccgtgt agttgagcca gccgatcgcg ttgggcagga
    23581 tgtcggcctc cacggccgcc gcgacctgct ccagccagtc cacgtcgagc ccggcctgca
    23641 cgaacgtcgg cgcgacccgc cagccctcct ggatgccgtg gtcgtcgagc cagtcggtca
    23701 gttcgtcctc ccggtcggag gcctccagcg ggctcagcac gggtgccttg gcgacgcgct
    23761 cggccgtgcg ctcctggatc tcgatcagtt tggcgagcac ctcgcgggag taggcgccct
    23821 gcgagatgac ggcgagcttg tgccgcatct tcgccacccg ttcccgcagc gtcgccgtgg
    23881 cccgtacggc cgcggcggcc gggttgttga gttcgtgcgt gagcccggcc gacaacgagc
    23941 cgagggccag cagccgctcg cgctgcccga tggcccgctg ggtgttcttc gagccgaaga
    24001 acagcccctc cagcagatgc gcggccatcg ggaaccactc gcgcatgatg tccgagaacg
    24061 actcggcggg cagcacgaag aagcgggtcg gttcggtcac ccgcatcgag ttgttgtaga
    24121 cctgcggcac ccggtccccg aggtacgcct gcatcgcgcc cgcgtacacc ccgcgctgcg
    24181 aggtgcggct gacctcgacg tcgtcggcgc cgacccggcg gtacagcacc accgtgccct
    24241 cgatcatcac gtagaagcag gtcgccgggt cgccctcggt gtacaccgga ccggcctcga
    24301 accgctccac ccgcccctcg gcgcacagcc gtccgagctg ctcgggggag agcttctcga
    24361 acaggaacag cgtgctgatc tcggccgcgt cgcagggcat cggccgcccg ctcacgactg
    24421 ctccaggtaa cggtggacga gcatgacggc catggctccc tctccgacgg cggacgcgac
    24481 gcgcttggcc gactcggcgc gcgcgtcgcc cgccacgaac acgccgggga tgttggtctc
    24541 caggtggtac ggcggccggt ccagctccca ttccgccggc ggccgcccgt ccgcggtgag
    24601 gtcgggcccg gccaggatga acccgagctc gtcgcgcagc accgtgccgt ccagccagtc
    24661 ggtcagcggg gccgcgccga tgaacacgaa catccactgc gcgtcgacga gttcgctcgc
    24721 cccgctgtcc acgtcccgca gggtgagctg ctccaggtgc tcctcgccgt gcgcggcctc
    24781 cacgacggta cgggtccgca cggagatgtt cggcgcctcc tcgatctgct ggatgaggta
    24841 gtgcgacatc gacgccgtga gggactcccc gcgaaccagc agcgtcaccg acttggcgcc
    24901 gcgcgccagg tacatcgccg cctggcccgc ggagttggcg ccgcccacga tgtacacgtc
    24961 ctgcccctgg caggaggccg cctcggtgag cgccgagccg tagtacaccc cgcagcccgt
    25021 caggtcgtcg cagcccggcg cgaggagctg gcggtacgac acaccggtcg ccaggatcac
    25081 gctgtgcgcg gcgaccgccg acccgtcgga gaaccgcacc acgcgggcgg ggccgcagac
    25141 ctccagtccc gtcacctcgc gcgcggtgag gatctcggcg ccgaacctgg ccgcctgccg
    25201 gcgggcccgg tcggtgagct gcgcgccgga cacgccgtcg gggaagccga ggtagttctc
    25261 gatgcgggag ctctgcccgg cctgtccgcc ggtcgcagac cgctccacca gcaccgtgcg
    25321 cagcccctcc gaggcgccgt agacggccgc gccgagcccg gccgggccgc cgccgatgac
    25381 cacgaggtcg tagaactcgg cctcgggggt cgtcgccagc cccacgtgcg aggcgagttc
    25441 gggggcgtcc ggctcgatca gcggtgtgcc gtcgggggtg atcaccagtg gcagccgctg
    25501 cccgtcggcg ccggccgcgg cgagcagccg ccgtccctcg ggctcgtcgg aggagtacca
    25561 gcggtagggc acctggttgc gggccaggaa ctcgcgcacg tccgaggagc gcgccgacca
    25621 gcggtgcccg acgaccttgg tggccggcac gggccggtgg tcgctggcgc gccacgccgc
    25681 gagcaggtcg tccacgaccg ggtagagctt ctcctccggc gggtcccacg gcttgaggag
    25741 gtagtggtcg aggtcgacca cgttgatcgc gtcgatcgcc gcgttggtgt cggcgtaggc
    25801 ggtcagcagc acgcggcgtg cgcccggata cacgtccagg gcctgttcga ggaactcgat
    25861 gccgttcatc tgcggcatgc ggtagtcggc caggatcacg gccaccaggt cgccgcgcag
    25921 cttcagctcg cgcagagcgc ccagcgcgga ctcgccggac tcggcgcgca cgatccggta
    25981 cgcgccgccg taacggcgcc ggagatcgcg ggcgacggcg cgggagaccc ccgggtcgtc
    26041 gtccacggtc agaatgacgg tccgcgcggt ctcggcggcc tgtgccatac gtctcccacc
    26101 ccgggggttc aggactcgcg gcacggcggg ccccgcgccg gtttccgccc atcgtatgtt
    26161 cgatcgcccc ggctcgctcc gggaccgggc aggccgtgcg ctcccggtac aggtccgggc
    26221 accggcggtg cacaggtggt cgacgcggcc gggctttcag ctcttgcggt cgctcagcac
    26281 gcagaactcg ttgccctcgg ggtccgccag tgtcacccag ctcacctcac cctgccccac
    26341 atcgacgtgg cgcgccccca gggccagcag acgctcgacc tccgcgcgct ggtcctcggg
    26401 ccggaagtcc aggtggagac ggttcttgac cgtcttggct tcgggcaccg gcccgaacag
    26461 caggcccggc agccggtcgg gggccggtct gatctcgaac tcctcggccg cgtcgttcac
    26521 cacgacccag ccgagcgcct cggcccacca gcgtcccagc gcgaccggat cggccgag
//
