LOCUS       NZ_CP099468            10216 bp    DNA     linear   CON 04-JUL-2024
DEFINITION  Streptomyces phaeoluteigriseus strain Qhu-M197 chromosome, complete
            genome.
ACCESSION   NZ_CP099468
VERSION     NZ_CP099468.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces phaeoluteigriseus
  ORGANISM  Streptomyces phaeoluteigriseus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
REFERENCE   1  (bases 1 to 9026270)
  AUTHORS   Zhang,B., Xiang,X. and Fan,J.
  TITLE     Complete genome sequence of soil microorganisms Streptomyces sp.
            Qhu-M197 isolated from Alpine meadows habitats on the Tibetan
            Plateau
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9026270)
  AUTHORS   Zhang,B., Xiang,X. and Fan,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-JUN-2022) Faculty of Eco-Environmental Engineering,
            qinghaiuniversity, No. 251 Ningda Road, Chengbei District, Xining
            City, Qinghai Province 810000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: Hifiasm v. v0.14; Circlator v. v1.5.5; Pilon v.
            v1.22
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 68.51291x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023923245.1-RS_2024_07_04
            Annotation Date                   :: 07/04/2024 06:06:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,100
            CDSs (total)                      :: 8,006
            Genes (coding)                    :: 7,707
            CDSs (with protein)               :: 7,707
            Genes (RNA)                       :: 94
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 299
            CDSs (without protein)            :: 299
            Pseudo Genes (ambiguous residues) :: 0 of 299
            Pseudo Genes (frameshifted)       :: 130 of 299
            Pseudo Genes (incomplete)         :: 241 of 299
            Pseudo Genes (internal stop)      :: 34 of 299
            Pseudo Genes (multiple problems)  :: 90 of 299
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:40:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3221704
            Orig. end                         :: 3231920
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP099468.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10216
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="11"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10216
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10216
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5216](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5216)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(1830..4049)
                     /locus_tag="NFX46_RS14370"
                     /old_locus_tag="NFX46_14370"
     CDS             complement(1830..4049)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978106.1"
                     /locus_tag="NFX46_RS14370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_14370"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_289782059.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 8.8e-37, bitscore:
                     124.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATETRGRRRAAPPRRAVPKSRVKTVRTPTVLQMEAVECGAASL
                     AMVLGHHGRHVPLEELRIACGVSRDGSRASNLLKAARGYGLTAKGMQMDLAALAEVRSP
                     AILFWEFNHYVVYEGLGRRFGRRGVFVNDPAKGRRFVPMEDFDGSFTGVVLVLEPGEDF
                     ERGGRRPGVLGAMPSRLRGTAGTLPAAVLASLLLVVVGAAVPALSRTYIDMFLISGQTS
                     LLEVLFASMGTCVLLTVALTWLQQANLHHGRIISSTLSSARFLRHLLRLPVTFFSQRSP
                     ADLVQRLQSNDAVAETLARDLASAGVDAVVVVLYAVLLYTYDPQLTFVGIGVALLNLVA
                     MRVVIRMRATRTAKLRADNARLTNTAYTGLQLIETMKATGGEDGYFRKWAGQHATTLEE
                     QQRLGVPSAWLGVVAPTLATVNSALILWIGGMRAIEGAISVGLLVAFQALVARFTAPLT
                     RLNGVAGRIQDFAADVARLKDVENFRADPLYDRRSGGDSTRRLHGHVELENIGFGYSPL
                     DKPLLAGFDLSVGPGQQVALVGGSGSGKSTVSRLISGLYAPWEGVIRIDGQRLEDISRG
                     ALAASVSFVDQEVFLFEGTVRDNVALWDPSVPDEAVVEALRDAALYDLVVRRPGGIHSR
                     VEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSALDAETEQVVMDNLRRRGCACVV
                     IAHRLSTVRDSDEIVVLEHGTVVERGRHEDLLARGGAYAALVRER"
     gene            complement(4046..4852)
                     /locus_tag="NFX46_RS14375"
                     /old_locus_tag="NFX46_14375"
     CDS             complement(4046..4852)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="NFX46_RS14375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_14375"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_252549339.1"
                     /transl_table=11
                     /translation="MQFRQQALTKLQSPEALDLPVRFARPQGWLVLSVTMVVMAAASVW
                     AVTGSVTSTVSAPAVLTHGEGSYILQSPAAGQVTAVLAKEGERLPAGSPVLKVRTADGE
                     TVVRTVAAGRITTLAATIGQIIATGANVAAMEKVARADDPLYATVYVPAENAASVPADA
                     AVDLTVQTVPSQRYGVLRGHVKSVDRTARSAQQISAFLGDSQLGEQFTEEGRPVAVLVR
                     LDRSSATESGYRWSSADGPPYALTSMTVATASIRLADQRPLDWLLP"
     gene            complement(5001..5216)
                     /locus_tag="NFX46_RS14380"
                     /old_locus_tag="NFX46_14380"
     CDS             complement(5001..5216)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="NFX46_RS14380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_14380"
                     /product="hypothetical protein"
                     /protein_id="WP_073495709.1"
                     /sec_met_domain="strepbact (E-value: 5.6e-35, bitscore:
                     118.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSTPQVETVEIADADLDNVSGGLSVHALGTVTGLVDGIAPVSGL
                     VDTVVGTVEGATGLSTAPVTNLVAGL"
     misc_feature    5449..5464
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.45"
                     /tool="antismash"
     gene            complement(5671..6084)
                     /locus_tag="NFX46_RS14385"
                     /old_locus_tag="NFX46_14385"
     CDS             complement(5671..6084)
                     /EC_number="3.1.2.-"
                     /GO_function="GO:0047617 - fatty acyl-CoA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676669.1"
                     /locus_tag="NFX46_RS14385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_14385"
                     /product="PaaI family thioesterase"
                     /protein_id="WP_073495706.1"
                     /transl_table=11
                     /translation="MTMTTTEADKILSDSFAPWVRALGLSVEALGDDRAILRLPWSTEL
                     AREGGGLSGQALMAAADTATVIAVSAARGAFVPMTTVQQSTSFQRAVTDSDVLIQAVLT
                     KLGRRMAFADVTMTAERSGELAARASTVYALLG"
     misc_feature    6075..6095
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.43"
                     /tool="antismash"
     misc_feature    6268..6277
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.44"
                     /tool="antismash"
     misc_feature    6271..6284
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.24"
                     /tool="antismash"
     gene            6274..7683
                     /locus_tag="NFX46_RS14390"
                     /old_locus_tag="NFX46_14390"
     CDS             6274..7683
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016430713.1"
                     /locus_tag="NFX46_RS14390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_14390"
                     /product="S1 family peptidase"
                     /protein_id="WP_252549341.1"
                     /transl_table=11
                     /translation="MSHKRIPKRKAAIAVGGVAALGAAALLLPHANASQDGGDTAAAAP
                     RTMKAADASDLASQLQNLLGDAFAGSYFDTGKNQLVVNVVDVSGDQNNVIVQAKKAGAK
                     VREVENSTAELKAAAQTLKADATIPGTSWAVDPRTNKILVTADSTVTGGKWDRLESTVQ
                     NLGAGTATIKKSAGTFKTFASGGDAIFAGGARCSLGFNVTAGDGSPAFLTAGHCGVAAE
                     AWSDSEAGEPIATVDQAVFPGEGDFALVKYDDPATVAPSEVDLGDQTVQISQAADATVG
                     TQVFRMGSTTGLADGQILGLDATVNYPEGTVTGLIQTDVCAEPGDSGGSLFTQDGLALG
                     LTSGGSGDCTVGGETFFQPVTTALEAVGATLGDAGAGAGAGADEGVGAEDGVGGEEAGA
                     GAGEGADAGAGEGAGEGAAEEVGGQEVGGEAGAGEEAGQEDAGQDAGGAAGAEDQNGDG
                     VQDDSGLTETH"
     gene            complement(7817..9964)
                     /locus_tag="NFX46_RS14395"
                     /old_locus_tag="NFX46_14395"
     CDS             complement(7817..9964)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057833.1"
                     /locus_tag="NFX46_RS14395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_14395"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_252556458.1"
                     /transl_table=11
                     /translation="MVAVSDGQLSPRAPGGPAGRSMLAPALTAMMDAVGAHSGAVYLLP
                     DDEPVLEMAVMAGLPRSFAAPWQRVGVGAPIPIARAVRERRLVWVGGEEEMARSYPRIA
                     VVLPYPFALAALPLATGSKVYGAVFVTWPGSHPPELSDRERHELQAACERLALRLERAA
                     AENRPVRGESDPLDTRPAAADTLGTVEAARLVARLPYGLCSLDLSGRVGFANPAAADLL
                     GVPVGKLLGTHLWASVPWLADPMYEERYRAALISQHVTSFVALRPPSAWLSFRLYPSTT
                     GISVRVVRARAVSVTSPAGTEGDDAPPRLVSMSQALSLAGALTETVSVQDVVRLVAEEI
                     APAVGSGALALLGARAGRLHVLGHHGYPDPHLVERFDGMPLATPTPGTHAVTHGVPAFF
                     DSRRQLEHLYPARHATPDGFAAWAYLPLIASGRPVGVCVLAYAEPHSFSTHERAVLTSL
                     AGLIAQALDRALLYDAKHRLAHGLQAALLPHSLPSLPGIEASARYLPATRGMEIGGDFY
                     DLVPSRPLPAAVIGDVQGHNVTAAGLMGQLRTAVRAYTTVGQEPAEVMRSTNRLMIDLG
                     TELFASCLYLRLDPAHGRAVMARAGHPPPLLRRPDGRVRVLDLAGGPLLGIDAEATYPT
                     TEITLSPGCVLALYTDGLIESPGVDIEDAVADLGRRLGEAGDLPLEALADELVGHYAAA
                     EERIDDVALLLLRASSARDRG"
ORIGIN
        1 gggcgaactg gccggcccag gcggcgtacg cgtagttctc ggcggcggcg acgcgcagct
       61 tgggcaggcc ccgcagggtc tggaacgcct ggttgttcag cttgttggag agcaccacca
      121 gcctgcgctg ccagcgcacc tgccacagcc ccagccccag gaacacggcg gcgatgacga
      181 cgagcatgcc gatcgcggcc agcgccatcg gcacgctgta ccagagcagc aggccgaggt
      241 tcacggcgcc gatggtgacg gactgcgcga ccgacgggcc gaggcccgcc agcagccggc
      301 ggatcgcgct gatgcccatg gcagcgctcg ccagctcacc cgtggagcgt tcggcgaaga
      361 acttcgtcgg cagcctcagc agccggtccc agacggccgg ctggagcgtc gcctcgatcc
      421 ggccctccag ccgcaggatg gtcatgttct ggaggagcat gaaggccgcc gccaccacgg
      481 cgctgaccag gacggccaga cacacctgct cgatcagccc ctgctgggcc cgcggcacgt
      541 actcgccgag caccttgccg gtcgcgaccg gcaccagcgc gccgatcgcc accgtgacga
      601 gcccgccgag cagcaggttc gtcaggtcgc gtccggtgcc ccgcatgctg aaccgcagca
      661 gcccgagcgg gccgagcggc cgctcgggca gcgggcggta gaacatgacg gcccgcggct
      721 cgaactcctc cgcgttggcc ttctccaccg gcgtctcgcg gccggtcgcg ggatggacgg
      781 cgacatagcc gccgcgccgc cacagcagcg cgaccggcgc cccggacagc gcccggtggg
      841 cgaccagcgg gccgacgtcg tcgcgccacc agcggccgtc cagtcgtacg gcgcgggtgc
      901 gcacgcggga ggcgagcgcg atctgctcga cagggtccag acggtcgttg ccggcgcccg
      961 tccgggtcgg ctcgacgagg gcgatgccgg cggcccccgc gaccagcttg caggcggcga
     1021 acgtggcgtc cgcgtccgcg gccgtcgcgc gcggccccgc cttgcggccg atcgacgcca
     1081 gcagcgtccg gtcggcctgg gcgcgcaccg cctcaccggc cttgatgccg gcggccgtgc
     1141 gcgtctcgtg ggtgtgctcc aactgctcga tccagcggtc gagggtggtc agcaggcggt
     1201 actgctggtc gaccatggac tgccacaccg ccgggtccat cagcaggtct gcggcggcct
     1261 ccgcgccgta cagcgagccg tactggacgc tgcccggcgg gacctgcatc cagaacacgt
     1321 cgtcgtcgtc ccccacgctc gaacggacgc gcgcgggggc atccccgtcc tcggcgggcc
     1381 gctcgccggc catcggggcc tggaagagga cggacagtcc gcggccgacg ccgagggcga
     1441 gggcgtactc cagcgggctc gacgcgggcg gcacgtacag ggggttgccg tactcgtcgt
     1501 aggaccagtt ctgggtgctc gcgggctggt acagctcgcg caggccgacg cggtggacca
     1561 cgcagtcgcg cagcgggcgg gccaccaggg tgtgctgggg gccggcgacc gggccgagca
     1621 gcagcgagcc cgcctccagc cggcccaggt ggtgccagtg gccccgctgt tccgcgtcca
     1681 ccgcgaacag gtccagcgcg ccggaggcga ccagccacag cacctgcggc ccctcgaggt
     1741 ccagccgtcc gaccccggtg cagtcgaccc gcgtgcccgt ccgccccaat gccgagagga
     1801 cgacatcgcc ttcgtgtacg gccgtcatct caccgctccc tgaccagcgc cgcgtacgcc
     1861 ccaccgcgcg cgagaaggtc ctcgtgccgt ccgcgctcca cgaccgtgcc gtgttcgagg
     1921 acgacgatct cgtcgctgtc gcggaccgtg ctgagccggt gcgcgatgac cacgcaggcg
     1981 cagccgcgcc ggcgcaggtt gtccatgacg acctgctcgg tctccgcgtc cagcgcgctg
     2041 gtcacctcgt ccagcaccag gatgctgggc cggcgcacca acgcccgtgc gatctccagg
     2101 cgttggcgct gaccgccgga gaagttgcgg ccgtcctgct cgacccggct gtggatgccg
     2161 cccggccgcc gcacgacgag gtcgtacagg gcggcgtccc gcagggcctc caccaccgcc
     2221 tcgtccggga cggaggggtc ccacagcgcc acgttgtcgc ggaccgtgcc ctcgaagagg
     2281 aacacctcct ggtcgacgaa ggagaccgag gcggcgaggg ccccgcgcga gatgtcctcc
     2341 agccgctgtc cgtcgatgcg gatcacgccc tcccacggcg cgtacaggcc cgagatcagc
     2401 cgggacaccg tcgacttgcc gctgcccgag ccgcccacca gcgccacctg ctgccccggc
     2461 ccgacactca ggtcgaagcc ggccagcagc ggtttgtcga gcgggctgta accgaagccg
     2521 atgttctcca gctcgacatg gccgtgcagc cggcgggtgg agtcgccgcc ggagcggcgg
     2581 tcgtagagcg ggtcggcccg gaagttctcc acgtccttca gccgggccac gtccgccgcg
     2641 aagtcctgga tgcggcccgc cacaccgttc agccgggtca gcggagcggt gaaacgggcg
     2701 accagcgcct ggaaggcgac cagcagaccc accgagatgg cgccctcgat cgcccgcatc
     2761 ccgccgatcc acaggatcag cgcgctgttg acggtggcca gcgtcggcgc gaccacgccc
     2821 agccaggcgc tgggcacccc gagccgctgc tgctcctcca gcgtggtggc gtgctgcccg
     2881 gcccacttgc ggaagtagcc gtcctcaccg ccggtcgcct tcatcgtctc gatcaactgg
     2941 agcccggtgt acgccgtgtt ggtcagccgc gcgttgtccg cgcgcagctt cgccgtgcgg
     3001 gtcgcgcgca tccggatcac cacgcgcatc gcgaccaggt tcagcagggc cacgccgatg
     3061 ccgacgaacg tcagctgcgg gtcgtaggtg tagaggagga ccgcgtacag gacgacgacc
     3121 accgcgtcca cgcccgccga cgcgaggtcg cgggccaggg tctcggccac cgcgtcgttc
     3181 gactggaggc gctgcaccag gtcggccggg ctgcgctggg agaagaaggt gaccggcagc
     3241 cgcagcagat ggcgcaggaa gcgggcgctg gacagcgtcg aggagatgat ccggccgtgg
     3301 tgcaggttgg cctgctggag ccaggtcagt gcgacggtga gcagcacgca ggtgcccatc
     3361 gacgcgaaca gcacctccag cagggaggtc tgaccgctga tcaggaacat gtcgatgtag
     3421 gtccggctca gtgccgggac ggccgcgccc accacgacca gcagcaggct cgccagcacg
     3481 gcggccggta gcgtgcccgc ggtgccccgc agccgggacg gcatcgcgcc cagcacaccc
     3541 ggcctgcgcc cgccgcgctc gaagtcctcc ccgggctcca gcaccagcac cacgccggtg
     3601 aagctgccgt cgaagtcctc catcggcacg aaccggcggc ccttggcggg gtcgttgacg
     3661 aacacacccc ggcggccgaa gcgccggccg aggccctcgt agacgacgta gtggttgaac
     3721 tcccagaaca ggatcgcggg cgacctcacc tcggcgaggg ccgccaggtc catctgcatc
     3781 cccttggcgg tcagtccgta accgcgggcc gccttcagga ggttgctcgc gcgcgagccg
     3841 tcccgcgaca ccccgcacgc gatgcgcagt tcctccagcg ggacgtgccg gccgtggtgg
     3901 ccgaggacca tggcgaggga ggcggccccg cactccacgg cctccatctg gagcacggtg
     3961 ggcgtgcgga cggtcttcac ccggctcttg gggaccgcac gcctgggcgg cgcggcccgc
     4021 cgtctgccgc gggtctcggt cgcggtcacg gaagcagcca atcgagcgga cgctggtcgg
     4081 ccagccggat cgaggcggtg gccacggtca tggaggtgag cgcgtacggc ggtccgtcgg
     4141 ccgacgacca cctgtagccg ctctccgtgg ccgaggagcg gtcgaggcgg accaggaccg
     4201 cgaccgggcg gccctcctcg gtgaactgtt cgcccagttg gctgtcgccg aggaacgcgg
     4261 agatctgctg cgccgaccgc gccgtgcggt ccaccgactt cacatggccg cgcagcacgc
     4321 cgtaccgctg cgacggcacg gtctgcacgg tcaggtcgac ggccgcgtcg gccgggacgg
     4381 aggccgcgtt ctccgccggg acgtacaccg tcgcgtagag cgggtcgtcg gcccgcgcga
     4441 ccttctccat ggcggcgacg ttcgcgccgg tggcgatgat ctgaccgatg gtggcggcga
     4501 gcgtggtgat ccggcccgcg gcgaccgtgc gcaccacggt ctcgccgtcg gcggtacgca
     4561 ccttcagcac gggggagccg gcgggcagcc gctcgccctc cttcgcgagg accgcggtga
     4621 cctggccggc ggcgggactc tggaggatgt agctgccctc gccgtgggtg aggacggcgg
     4681 gcgcgctcac cgtggaggtg accgaaccgg tcaccgccca cacggacgcg gcggccatga
     4741 cgaccatggt cacggacagc accagccagc cctgggggcg ggcgaagcgc accggcaggt
     4801 cgagtgcctc gggtgactgg agcttggtga gggcctgttg gcggaactgc acgggacttc
     4861 cctcgggggt tcacggcacc gactcggggg ttcacgggag cgagccgggg ttgcacgggg
     4921 ccgggccggg ggtcgcgcgg caccgaggag tcccggaacc gggtgacggc tccgggactc
     4981 aaagggtcac aagggcgcga tcagagaccg gcgaccaggt tggtgaccgg ggcggtgctc
     5041 aggccggtcg caccctcgac ggtgccgacg accgtgtcga ccaggccgga gaccggggcg
     5101 atgccgtcca ccaggccggt gacggtgccg agggcgtgca cggacaggcc accggagacg
     5161 ttgtcgaggt cggcgtcggc gatctcgacg gtctcgacct ggggggtgga gttcatgggg
     5221 gaacttccct tcatatggat atctcacaag gggggagcgg ccccctctgg ggacagatga
     5281 cggccgcgat cgcgggcgcc gaaggcccgt ttccgtaaag ccccggcggg cccccgcgat
     5341 gcgttggatc aaagcaggtc cgccgccgac gcttccaatc aatcacccgc cccaccaggg
     5401 cacttgcgtc tcgggagagt caaagcgtgc aggcgcggcc acgccttgtc ggcgacttct
     5461 tcacacctcg ggccgagatc gctccgatga gcggcgcacg ccctcgcggc gaatccgaca
     5521 caccggtccc aatggcgcgg cggggaccgc gcggttgtgc agaagcccgg tgtcccgtga
     5581 cccgcttggg caatcggtgt gcagattccc tgaagcaggg attccgctct ccggtccgaa
     5641 cggtccgtca gcgaccggtc accttcggta tcagcccagg agggcgtaga cggtgctcgc
     5701 ccgtgcggcg agttcacccg agcgctcggc cgtcatcgtg acgtcggcga acgccatccg
     5761 gcggcccagc ttcgtcagca ccgcctggat caggacatcc gaatcggtca ccgcgcgctg
     5821 gaaggacgtc gactgctgca ccgtcgtcat cggcacgaag gccccccggg ccgccgagac
     5881 ggcgatcacc gtcgcggtgt ccgcggccgc catcaacgcc tgccccgaca gcccaccgcc
     5941 ctcccgcgcc aactccgtcg accagggcag acgcagaatc gcccggtcgt cccccagcgc
     6001 ctccacggac aggcccagcg cgcgcaccca gggcgcgaaa gagtcggaaa ggatcttgtc
     6061 ggcttcggtg gtcgtcatcg tcatatgggc gattgttccc cggccgacgg ccctcgaccc
     6121 cggtcatggc cgattcacgg tttcgcaaag gaagccggca aacgcgattg aacgcacccc
     6181 gcacctcctg cgtactgatg gccaaccagg cgccgctgta cggagctgcc gcccccggca
     6241 gccggacccc gtccccccag gaggtcgagt tttttgagtc acaagcgaat tccgaagcgc
     6301 aaggccgcga tagcggtggg cggtgtcgcg gcgctcggag cggcggcact cctgctgccc
     6361 cacgccaacg cctcccagga cggcggcgac acggctgccg cggcgccgag gaccatgaag
     6421 gcggcggacg cctcggacct ggcctcgcag ctgcagaacc tgctcggcga cgccttcgcg
     6481 ggttcctact tcgacaccgg caagaaccag ctcgtcgtca acgtcgtcga cgtctccggt
     6541 gaccagaaca acgtcatcgt ccaggccaag aaggccggtg cgaaggtacg cgaggtcgag
     6601 aacagcacgg ccgaactcaa ggccgccgcg cagacactca aggccgacgc gaccatcccg
     6661 ggcacctcct gggcggtcga cccgcggacc aacaagatcc tcgtcaccgc cgactccacg
     6721 gtgaccggcg gcaagtggga ccggctggag tccaccgtcc agaacctcgg tgccgggacc
     6781 gcgaccatca agaagtcggc cggcaccttc aagaccttcg cctccggcgg tgacgccatc
     6841 ttcgccggcg gagcgcgctg ctccctcggc ttcaacgtca ccgcgggcga cggctccccg
     6901 gccttcctga cggccggtca ctgcggcgtc gcggccgagg cctggtccga ctccgaggcc
     6961 ggcgagccca tcgccaccgt cgaccaggcg gtcttcccgg gcgagggcga cttcgcactc
     7021 gtgaagtacg acgacccggc cacggtcgcc ccgagcgagg tcgacctcgg cgaccagacc
     7081 gtacagatct cccaggccgc cgacgcgacc gtcggcaccc aggtcttccg gatgggcagc
     7141 accaccggtc tcgccgacgg gcagatcctc ggcctcgacg ccaccgtcaa ctaccccgag
     7201 ggcaccgtca cgggcctcat ccagaccgac gtctgcgccg agcccggcga cagcggcggc
     7261 tcgctgttca cccaggacgg cctcgcgctc ggcctgacct ccggcggcag cggcgactgc
     7321 acggtcggcg gtgagacctt cttccagccg gtgaccaccg ccctggaggc ggtcggtgcc
     7381 accctcggcg acgccggggc cggtgccgga gcgggcgccg acgagggtgt cggcgccgag
     7441 gacggcgtcg gcggcgagga ggccggagcg ggcgccggtg aaggcgctga cgcgggcgcc
     7501 ggtgaaggcg ccggtgaagg tgccgctgaa gaggtcggcg gccaggaggt cggcggcgag
     7561 gcaggcgccg gcgaggaggc aggtcaggag gacgccggtc aggacgcagg cggagcagcc
     7621 ggtgccgagg accagaacgg tgacggcgtc caggacgact ccgggctgac cgagacccac
     7681 tgacacaccg tccgcaccgc tcaccccgta ccaccggccg gacgtaccca cccgtccggc
     7741 cggtgccacg gtccggtcct ccggcgggag ggccggaccg tccgcgtttc cccggcgccc
     7801 ggccgttgac ggcgcgtcag ccccggtccc gcgccgacga ggcccgcagc aacagcagcg
     7861 ccacgtcgtc gatccgctcc tccgcagccg cgtagtgccc caccagctcg tcggccagcg
     7921 cctccagtgg cagatcgccc gcctcgccca gccgccgccc caggtccgcc accgcgtcct
     7981 cgatgtccac ccccggcgac tcgatcaacc cgtcggtgta gagggcgagt acgcagccgg
     8041 gcgacagcgt gatctccgtg gtcggatagg tcgcctccgc gtcgatgccc agcagcgggc
     8101 cgccggccag gtcgaggacc cgcacccgtc cgtccggccg ccgcagcagg ggcggcggat
     8161 gcccggcccg cgccatcacc gcgcgaccgt gcgccgggtc cagccgcaga tacagacaac
     8221 tggcgaacag ctccgtgccc aggtcgatca tcagccggtt ggtgctgcgc atcacctcgg
     8281 ccggttcctg ccccacggtc gtgtacgccc ttacggcggt gcggagttgc cccatcagcc
     8341 cggccgccgt cacgttgtgc ccctgtacgt ccccgatcac cgccgccggc agcggacgcg
     8401 agggcaccag gtcgtagaag tcgccgccga tctccatgcc ccgggtggcc ggcagatagc
     8461 gggcgctcgc ctcgatgccg ggcagcgacg gcagcgagtg ggggagcagg gcggcctgga
     8521 ggccgtgcgc gagccggtgc ttggcgtcgt acagcagggc ccggtccagg gcctgcgcga
     8581 tcagcccggc caggctggtc aggacggcgc gttcgtgcgt ggagaagctg tgcggctcgg
     8641 cgtaggccag cacgcagacg ccgaccgggc ggcccgaggc gatcagcggc aggtaggccc
     8701 aggccgcgaa gccgtcgggg gtggcgtgcc gcgccgggta gaggtgctcc agttggcggc
     8761 gggagtcgaa gaacgcgggc acgccgtggg tgacggcgtg cgtgccgggg gtgggggtgg
     8821 ccagcggcat tccgtcgaac cgctccacca ggtgcgggtc ggggtagccg tggtgtccca
     8881 ggacgtgcag tcggcccgcc cgtgccccga gcagcgccag ggccccgctg cccacggccg
     8941 gcgcgatctc ctcggccacc agtcgcacca cgtcctgcac gctcaccgtc tcggtgagcg
     9001 ccccggccag gctcagcgcc tgcgacatcg acaccagccg gggcggggcg tcgtcgccct
     9061 ccgtaccggc cgggctcgtc accgacaccg cccgggcccg gaccacccgc acactgatcc
     9121 cggtggtgct ggggtacagc cggaaggaca gccaggccga gggcgggcgc agcgcaacga
     9181 acgacgtgac gtgctggctg atcagcgcgg cccggtagcg ctcctcgtac atcgggtcgg
     9241 ccagccaggg caccgacgcc cacaggtggg tgcccagcag cttgccgacc gggaccccga
     9301 gcaggtcggc cgcggcgggg ttggcgaacc ccacccgccc cgacaggtcc agcgaacaca
     9361 ggccgtacgg cagccgggcc accagccgcg ccgcctccac ggtgcccagc gtgtcggcgg
     9421 cggccggccg cgtgtccagc ggatcgctct cgccgcgcac cggacggttc tcggcggcgg
     9481 cccgctcgag ccgcagcgcc agccgctcac aggccgcctg cagctcgtgc cgttcccggt
     9541 cggacagctc cggcggatgc gagccgggcc aggtcacgaa gaccgcgccg tacaccttcg
     9601 agccggtcgc cagcggcagc gcggccagcg cgaacgggta cggcaggacc acggcgatcc
     9661 gcggatagga gcgggccatc tcctcctcgc cgcccaccca caccaaccgc cgctcacgca
     9721 ccgcgcgcgc gatcgggatc ggcgcgccga cgcccacccg ctgccagggc gccgcgaacg
     9781 accgcggcag tcccgccatc accgccatct ccagcaccgg ctcgtcgtcc ggcagcaggt
     9841 agaccgcgcc ggagtgcgcc ccgacggcgt ccatcatcgc cgtcaacgcc ggggccagca
     9901 tcgaccggcc ggccgggccc ccgggcgccc ggggagacag ctgcccgtcg gacacggcga
     9961 ccacctcctc gcccggccgc accatcccag gcaaccaaat ctgccccctg cgggccgcgc
    10021 gcgcacggcg ggggtccggc cggtgccggg gcggcgcccg cccgacagga cagccgggcg
    10081 ggcggcggac cgacacacgg cagcacaaca ccccacctga cgcccaccgc gggggaacgg
    10141 ctcggcgggg ggtgcggtcg agtcggggag ggtggcgggt gcgaaggagg tggtggcggt
    10201 ggtggcggtg gtgggc
//
