LOCUS       NZ_CP099468            22163 bp    DNA     linear   CON 04-JUL-2024
DEFINITION  Streptomyces phaeoluteigriseus strain Qhu-M197 chromosome, complete
            genome.
ACCESSION   NZ_CP099468
VERSION     NZ_CP099468.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces phaeoluteigriseus
  ORGANISM  Streptomyces phaeoluteigriseus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
REFERENCE   1  (bases 1 to 9026270)
  AUTHORS   Zhang,B., Xiang,X. and Fan,J.
  TITLE     Complete genome sequence of soil microorganisms Streptomyces sp.
            Qhu-M197 isolated from Alpine meadows habitats on the Tibetan
            Plateau
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9026270)
  AUTHORS   Zhang,B., Xiang,X. and Fan,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-JUN-2022) Faculty of Eco-Environmental Engineering,
            qinghaiuniversity, No. 251 Ningda Road, Chengbei District, Xining
            City, Qinghai Province 810000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: Hifiasm v. v0.14; Circlator v. v1.5.5; Pilon v.
            v1.22
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 68.51291x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023923245.1-RS_2024_07_04
            Annotation Date                   :: 07/04/2024 06:06:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,100
            CDSs (total)                      :: 8,006
            Genes (coding)                    :: 7,707
            CDSs (with protein)               :: 7,707
            Genes (RNA)                       :: 94
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 299
            CDSs (without protein)            :: 299
            Pseudo Genes (ambiguous residues) :: 0 of 299
            Pseudo Genes (frameshifted)       :: 130 of 299
            Pseudo Genes (incomplete)         :: 241 of 299
            Pseudo Genes (internal stop)      :: 34 of 299
            Pseudo Genes (multiple problems)  :: 90 of 299
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:40:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2197842
            Orig. end                         :: 2220005
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP099468.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22163
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="False"
                     /product="terpene"
                     /product="butyrolactone"
                     /region_number="5"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..22163
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /detection_rules="AfsA"
                     /kind="neighbouring"
                     /product="terpene"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..22163
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12163](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12163
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(456..467)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.19"
                     /tool="antismash"
     misc_feature    535..548
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.33"
                     /tool="antismash"
     misc_feature    complement(700..715)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.58"
                     /tool="antismash"
     misc_feature    complement(814..829)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.12"
                     /tool="antismash"
     cand_cluster    989..11891
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    989..11891
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5988:6891](+)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      5989..6891
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
     misc_feature    1083..1097
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.09"
                     /tool="antismash"
     gene            1233..1874
                     /locus_tag="NFX46_RS09880"
                     /old_locus_tag="NFX46_09880"
     CDS             1233..1874
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675693.1"
                     /locus_tag="NFX46_RS09880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_09880"
                     /product="Tat pathway signal sequence domain protein"
                     /protein_id="WP_252547938.1"
                     /transl_table=11
                     /translation="MRTRPLLALAATVAALSLTAATPASAADPAVLTTANGDVAVGDVL
                     TASLASGTNATLYSSATGTSGVSCASSGFTATVTANPTAPGTATESLTGHTFGNCSANV
                     VGVLGVTSITVNNLPYSTAVSSAGTVTVTPPAGSVIQTTVVLRTLLGSINCVYRAPSLT
                     GTASNADNSITFTGQQFTKSSGSSLCFANGYFSAKYAPVTAAGGAAVTVN"
     gene            complement(1939..2892)
                     /locus_tag="NFX46_RS09885"
                     /old_locus_tag="NFX46_09885"
     CDS             complement(1939..2892)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034207.1"
                     /locus_tag="NFX46_RS09885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_09885"
                     /product="lytic polysaccharide monooxygenase"
                     /protein_id="WP_252556288.1"
                     /transl_table=11
                     /translation="MRRTTTDRTAALAATALSPLLPVLLWAAAPAQAHGAPTTPVSRVH
                     ACSPDGGPPSGSAACRAAVAANGAPFTAWDNLRVANVNGRDRSTIPDGQLCSGGLPAYR
                     GLDLARSDWPSTRLTSGGTLRMTYVSTIPHTGTFRFYLTKPGYDPSQPLTWNDLPERPF
                     AQVKDPVLRDGAYRLTAELPADRTGRQVLYTVWQNSSTPDTYYSCSDVVFPEKAAAAAS
                     PSAATAGSPKPPSADPSVPSGTTAGTSAGTTPSAAPASGAATASGAPAAATPASTPVAT
                     ASGTGSGPSAPMLAGGAAAVLVLIGGATLVLRLRRR"
     misc_feature    3069..3082
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.68"
                     /tool="antismash"
     gene            3252..5063
                     /locus_tag="NFX46_RS09890"
                     /old_locus_tag="NFX46_09890"
     CDS             3252..5063
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020122073.1"
                     /locus_tag="NFX46_RS09890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_09890"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_252547941.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 8.9e-49, bitscore:
                     165.2, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTSPALGRKLISVAAVSAALLTAATTASVAATPDGASREAAAVP
                     AAQTEAAPGTPAERLIVGYKSAAAEARSNQAAEADAAAKGEETGEDLDFERRLGTGAAL
                     VDLGSGLTGADVADVVAEYRADPQVAYVVPDRLNTAKADPNDTEYAKQWDLYEATAGMN
                     VPGAWATTTGTGVTVAVIDTGYVAHTDLAANIVGGYDFIADTAVSVDGDGRDSNPADPG
                     DWYNANECGSGVPAGSSSWHGTHVAGTIAAVTNNGKGIAGIAHGAKISPVRVLGKCGGY
                     DSDIIDAITWASGGTVSGVPANTNVAKVINMSLGGDGACTSATQSAINAAVSRGTTIAV
                     AAGNENDNVANHSPGNCNNVISVAATSRTGAKASYSNYGSLVDISAPGGQTSTGTANGI
                     LSTLNSGAKTASTESYAYYQGTSMATPHIAGLVALMKSANSSLTPAQIETAVKSNARAL
                     PGACSGGCGAGLADAARTVQAVSGSGGSTGGTTFTSTTAVAIPDNGSAVESSIAVTGRT
                     GNAPTALQVGVDITHTYRGDLVIDLVAPDGTAYRLKASSTSDSADNVVTTYSVNASSEV
                     AGGTWKLRVQDVAAQDTGRVNSWKLTF"
     gene            complement(5160..5810)
                     /locus_tag="NFX46_RS09895"
                     /old_locus_tag="NFX46_09895"
     CDS             complement(5160..5810)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1224: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020122072.1"
                     /locus_tag="NFX46_RS09895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_09895"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_073499025.1"
                     /transl_table=11
                     /translation="MAKQERAIRTRRAIVEAAGAVFDEHGYTSTTIAMVLERAQVTKGA
                     LYFHFASKEALAQAVLNEQVPFGAVPPQPCKLQEIVDMTFVVARRLLDNALLRGSVRLA
                     VDQETPSGVDHGEPFRQWAQALTELLELAGERGELLPTVKPAETVDLLVGTFTGVQLMS
                     RALTDRADLGDRLSVMWAHILPSIAVPGLLPGLDARADRGTRVLASLEQRVAS"
     misc_feature    complement(5893..5906)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.49"
                     /tool="antismash"
     gene            5989..6891
                     /locus_tag="NFX46_RS09900"
                     /old_locus_tag="NFX46_09900"
     CDS             5989..6891
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020133701.1"
                     /locus_tag="NFX46_RS09900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_09900"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_252547947.1"
                     /sec_met_domain="AfsA (E-value: 2.1e-22, bitscore: 77.8,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRPRQLADTPSLTATVPRQLVHRAALAETFLTGWRRTGADRFTV
                     SAQWPRAHGLHVSPDWSAYDPLLVVETIRQSGTLVSHTEYEVPLDQQFVLKEFHVTTEP
                     WALTLGPRPAEPEVELVFTDVQYRGRRPVGARYTARVVRDGTLVAAADVSFSCVSEPVY
                     QRLRGGRTPDTVTAVPLPPGVPADAVDRALPTDVVLAPTDRPDRWQLRVNTAHPVFFDH
                     PLDHVPGMLLLEGARQAALLETPGKRVPTAYHAVFHRYAELDVPTWIEAKAAHDGDVQV
                     VGVQGESTVFACLVGTAGP"
     misc_feature    6151..6153
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6962..7615
                     /locus_tag="NFX46_RS09905"
                     /old_locus_tag="NFX46_09905"
     CDS             6962..7615
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010353235.1"
                     /locus_tag="NFX46_RS09905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_09905"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_252547951.1"
                     /transl_table=11
                     /translation="MARQLRAEQTRATIIRAAADLFDRNGYESTSLSDIVERAQVTKGA
                     LYFHFAAKEDLAQAILELQSQASRRVAGEIDDRGYPSLEALMRLTFGMVRLSVEGPVAR
                     AGLRLATGGVPVRPPVPHPFTEWMELMSRRLVGAVRESDIHPDVDVDAVAHSLVCFFVG
                     TRVVGRSREPGTRLPRRLAEMWHVLIRGLVPVPRRPRYLSLAARLEREVMAAAV"
     gene            8673..9866
                     /locus_tag="NFX46_RS09910"
                     /old_locus_tag="NFX46_09910"
     CDS             8673..9866
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034217.1"
                     /locus_tag="NFX46_RS09910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_09910"
                     /product="damage-control phosphatase ARMT1 family protein"
                     /protein_id="WP_252547956.1"
                     /transl_table=11
                     /translation="MSDTPMPPVPPVILGDEPGSFARGVLAERHPAIIRRVRDAFPYGP
                     DVRRALDALLTSCVEGVIEPLPADAHDRDRWRAWGLDGYAGRSWYEVPWLWSESYFYRL
                     LLETVGYFRPGPWQGLDPFRPFKLAELDAPETDEELAALDGLEGRPEPERAQALLHGSL
                     WGNRADLGFRLSDAGARDRAAVPGLVADDSETLWALLAPPQAADGTLCLVADNAGRELI
                     PDLLLAAHLLAHGRAGRVVLHVKPYPYYVSDATTADVVDALRRLTAAPGTAGGYGRRLW
                     AAMADGTLTVRAHPFAAAPLPYERMPDDLRAEFVGAALTIVKGDLNYRRLVGDRLWPPT
                     TPFADVTAHFPGPVVALRTLKSDVITGLSAGTEAALTAAEGRSWRTGGTHALIQTRK"
     gene            10001..12163
                     /gene="cyc2"
                     /locus_tag="NFX46_RS09915"
                     /old_locus_tag="NFX46_09915"
     CDS             10001..12163
                     /EC_number="4.1.99.16"
                     /EC_number="4.2.3.22"
                     /EC_number="4.2.3.75"
                     /codon_start=1
                     /gene="cyc2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675700.1"
                     /locus_tag="NFX46_RS09915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_09915"
                     /product="germacradienol/geosmin synthase Cyc2"
                     /protein_id="WP_252547959.1"
                     /sec_met_domain="T1TS (E-value: 2.5e-80, bitscore: 269.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFELPHFYMPYPARLNPHLDEARAHSTAWAREMGMLEGSGIW
                     EQADLDAHDYGLLCAYTHPDCDGPALSLITDWYVWVFFFDDHFLDMFKRTPDRAAGKAH
                     LDRLPLFMPLDLATPVPKPENPVEAGLADLWARTVPAMSADWRRRFAVATEHLLNESMW
                     ELSNINEGRISNPVEYIEMRRKVGGAPWSAGLVEYATAEVPASVAGSRPLRVLMETFSD
                     GVHLRNDLFSYQREVEDEGELSNGVLVLETFFGCTTQEAADTVNDILTSRLHQFEHTAV
                     TEVPALALENGLGPDEVAAVAAYTKGLQDWQSGGHEWHMRSSRYMNKGAGSTSPWEKLT
                     RPGTSAADVGALLASAAAERMRAYTHVPYQKVGPSRLPEFHMPFQVELSPHLDRARHNL
                     VGWTRRMGMLSEGVWDEDKLASCDLAVCSAGLDPDAGPEALDLSASWLAFGTYGDDYYP
                     LVYGHRRDLAAARVTTARLSACMPVDGEETVVPLNAMERSLIDLWARTTAGMTPDQRRT
                     LRAAVDSMTESWVWELSNQLQNRIPDPVDYLEMRRATFGSDLTLSLCRMGQGPAVPPEV
                     YASGPVRSLENAAIDYACLLNDVFSYQKEIEFEGEVHNAILVVQSFFGCDYPTALGVVH
                     DLMTQRMQQFEHVVAHELPILYDDFGLSAEAREAMRGYVTDLQNWMAGILNWHRVVDRY
                     KDSYLSRRSHGFLPDRPPAVPALPVG"
     gene            complement(12494..13249)
                     /locus_tag="NFX46_RS09920"
                     /old_locus_tag="NFX46_09920"
     CDS             complement(12494..13249)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431963.1"
                     /locus_tag="NFX46_RS09920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_09920"
                     /product="hypothetical protein"
                     /protein_id="WP_252547962.1"
                     /transl_table=11
                     /translation="MTDSTAQIAGTARIAKVALVGDHSPNVVSHTRIPLLLDALAARDR
                     LVLDAYWIPSADAEAEDAVRGFDAVWVVPGSPYRSEAGVLAAIRTAREEGIPFLGTCGG
                     FQHALLEFARNACGLAHAAHAENDPGAEDPLLEPLACSLEGHEDTVLLEPGSLAREVIG
                     LESTVERYSCRYGLSRHFDTLVAHGLRFSGRDAAGQVRMAELPGHPFFLASLFQPELYG
                     DGSRPHPMLRGLARAAVGHATRRTAARSV"
     gene            13337..14203
                     /locus_tag="NFX46_RS09925"
                     /old_locus_tag="NFX46_09925"
     CDS             13337..14203
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125299.1"
                     /locus_tag="NFX46_RS09925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_09925"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_252547965.1"
                     /transl_table=11
                     /translation="MDPHLLRTYVTVARLASFSEAARDLGYTQSAVSQHIAALEQDLGA
                     PLLTRRPVAPTAAGERLLEHAGPLLLRLAAARADVVRMADAPDHGLTLAASATALTPAT
                     LAALPSAGVTLRVLARDEVPAAVAAGTADVGLVDGLAAPSDPLRLPDVAPLTTHGVGEE
                     PVGVLLPAGHPLARRTGLRLGDLADARWIDAPDTGLPLPQLRAANGGRGFRPALRYDGT
                     DVRVLAALAAAGHGLTLLPRSATADTPGAVAVPLTAPRVVHRVELVHAGTPTGAARALA
                     AALSPRA"
     gene            14311..14889
                     /locus_tag="NFX46_RS09930"
                     /old_locus_tag="NFX46_09930"
     CDS             14311..14889
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006381304.1"
                     /locus_tag="NFX46_RS09930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_09930"
                     /product="PDZ domain-containing protein"
                     /protein_id="WP_252547967.1"
                     /transl_table=11
                     /translation="MEQTALRPKPMPGQEPGGGPPSDGRPHHPHAARRRGRHLTTLLSG
                     LFVGTVLVLSGVGLGTVGATVIGASKLAELQRQAGGAAPGAVSQAGPSPSAQDSPAAAP
                     ADATLGLEIVDAEKAGAEIVAVHVPGPGYSAGLVRGDLVLHFGRVRIDSAGDLARAVDE
                     ARPGREIKVTVRHKSGGYQQLTVVPGIVT"
     gene            complement(14923..15678)
                     /locus_tag="NFX46_RS09935"
                     /old_locus_tag="NFX46_09935"
     CDS             complement(14923..15678)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006381334.1"
                     /locus_tag="NFX46_RS09935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_09935"
                     /product="phosphodiesterase"
                     /protein_id="WP_252547969.1"
                     /sec_met_domain="Metallophos_2 (E-value: 4.6e-08, bitscore:
                     32.1, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLVLAHISDLHLDGSARATERAERVCERLRNLPGRVDALLVTGDI
                     ADHGTEAEYEEAARILGPHGPRTPWPVLTCPGNHDRRAPYRKALLGRPAADGPVNSVQV
                     FDGGAVLMCDSSIPGEDEGALADETYAWIEETLDELDGDVPALLAFHHPPVSLHHPLPD
                     GYRLRDPGRLAALLERRPEIAGIITGHAHSPAATTFAGRPLVVGPGVTWTLRLPWEGEE
                     IADREAPVGLAFHVLDEDRRLTSHFRVVV"
     misc_feature    complement(15733..15747)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.39"
                     /tool="antismash"
     gene            15896..17023
                     /locus_tag="NFX46_RS09940"
                     /old_locus_tag="NFX46_09940"
     CDS             15896..17023
                     /EC_number="3.4.11.9"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070006 - metalloaminopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996926.1"
                     /locus_tag="NFX46_RS09940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_09940"
                     /product="aminopeptidase P family protein"
                     /protein_id="WP_252547970.1"
                     /transl_table=11
                     /translation="MTGRTPARFTADDYRARMERAVRAAADAGLAGLLVAPGPDLVWLT
                     GYAPPAVTERLTLLVLTPDRDPVLVVPALEAPDAAEAVGAPALTLRDWTDGKDPYAATA
                     ALLDTGKRFGVSDNAWALHLLRLQKALPDSSYASLTEALPMLRAVKDAAELELMAAAGA
                     AADATYEEIRKVPFAGRRESEVGADLADLLRRFGHSQVDFTIVASGPNGANPHHEVGDR
                     VIEHGDMIVLDFGGLKDGYGSDTSRTVHVGEPTDEERRVHDLVREAQEAGFRAVRPGVA
                     CQEIDRAARAVIADAGYGEYFIHRTGHGIGVTTHEPPYMIEGEEQPLVPGMCFSVEPGV
                     YLPGRFGVRIEDIVTVTEDGGRRLNDTTREMVMVD"
     gene            17071..18009
                     /locus_tag="NFX46_RS09945"
                     /old_locus_tag="NFX46_09945"
     CDS             17071..18009
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125303.1"
                     /locus_tag="NFX46_RS09945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_09945"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_252547972.1"
                     /sec_met_domain="APH (E-value: 9e-17, bitscore: 60.6,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQASTPTADTVRRLVRTLLEVGGEGGPGPEVRPVTEEGGHGTWW
                     VGTRHVLRLAPDREATVRMRRELRLRDLVRPHVPVAVPTSVAHGEWSPGLTYTLDTKVP
                     GGTAEEHDVSAVGEADLAGLLGGLREVPARQAETVGVPRVAPRSLEALRRMAVAAAQRL
                     ADEDEFDPARLHQLTPPGAVQLAAQPATAVLVHHTLRGEHLVVGADGRVRGVLDWTGAV
                     VGDPAEDIAGLALAVGSGAAVRAATLTGYGARACLRGLWLARCDTVVRLAERLTGHGTE
                     SPALLRTQLRRSWEAILLERVTELREDGADD"
     gene            complement(18052..19797)
                     /gene="treZ"
                     /locus_tag="NFX46_RS09950"
                     /old_locus_tag="NFX46_09950"
     CDS             complement(18052..19797)
                     /EC_number="3.2.1.141"
                     /GO_function="GO:0033942 -
                     4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="treZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CBM_48"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297: Pullulanase, type I"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034231.1"
                     /locus_tag="NFX46_RS09950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_09950"
                     /product="malto-oligosyltrehalose trehalohydrolase"
                     /protein_id="WP_252547974.1"
                     /sec_met_domain="CBM_48 (E-value: 0.00012, bitscore: 21.2,
                     seeds: 59, tool: rule-based-clusters)"
                     /sec_met_domain="Alpha-amylase (E-value: 2.3e-11, bitscore:
                     42.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFEVWAPQAERVTLQCDGVTSALERDAARPGWWSGEAEARDGTR
                     YGFAVDDGPVRPDPRSRRQPDGPDGLSAVVDHGRYAWRAAWQGRPLPGAVLYELHVGTY
                     TAEGTLDAAADRLGHLVELGVTHVELMPLCPFPGRHGWGYEGVSLWAVHEPYGGPEALK
                     RFVDRAHELGLGVVLDVVHNHLGPSGNYLPVFGPYFTDTHHTPWGSAVNLDAPGSDEVR
                     AFLLDSALAWLRDYQIDGLRLDAVHALADTRAYPFLEELSESVDALAAETGRPLFLIAE
                     SDLNDPRLITPRREHGLGLHAQWNDDFHHALHTALTGESQGYYADFARDPFAALAKTLT
                     GGFFHDGTYSSFRDRSHGRRLDHTRLPAHRLLGYSQTHDQVGNRAQGDRLAASLSPGLL
                     ACAAALTLTSPFTPMLFMGEEWAAGTPWQFFTDHTDPDLAEAVRNGRRREFAAHGWAEE
                     EVPDPQDPATRDRSCLDWSEPEREPHARVLAWYRRLIALRHAQADLTDPDLADLKVAYD
                     TQARWLAFRRGDIRVAVNLGEAPAAIPLGTRPARVLAAWEPVDAPGPDGLLRLPGESCV
                     VLEQD"
     gene            20011..20562
                     /locus_tag="NFX46_RS09955"
                     /old_locus_tag="NFX46_09955"
     CDS             20011..20562
                     /GO_function="GO:0051219 - phosphoprotein binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385491.1"
                     /locus_tag="NFX46_RS09955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_09955"
                     /product="DUF1707 and FHA domain-containing protein"
                     /protein_id="WP_073498204.1"
                     /transl_table=11
                     /translation="MTSSFEFNTYPARLSDVERDRALKVLRDGAAMGRLSHDTFIRRME
                     LALAARRSEELAVLTADLPSENRFSRALFGTVEAVSGFTVRLRRAWQAERLPKLLLPHP
                     GTAQALRIGRDPASGLRLTHDSVSRVHAELSRQGGMWILRDLGSTNGTTVNGRRVIGAA
                     VVREGDQVAFGRMAFRLSVN"
     gene            20684..22033
                     /locus_tag="NFX46_RS09960"
                     /old_locus_tag="NFX46_09960"
     CDS             20684..22033
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006381315.1"
                     /locus_tag="NFX46_RS09960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NFX46_09960"
                     /product="M14 family zinc carboxypeptidase"
                     /protein_id="WP_252556290.1"
                     /transl_table=11
                     /translation="MPPLLRYPTADELAARAAALVARRPRDTRLRRVGVSRAGTPLWLL
                     SVGHGTRQALIVAGPHANEPVGGATVLRLAERVLADPRLTEDADATWNLLLCLDPDGLR
                     RNEGWLSGPYTLGRYFRHFFRPGFLEQPEWLPDGAQAAALPETRALLGLQDELKPFFQC
                     SLHGVDVGGGFVELTRDLPGLPQRVAHAAARLGIPRELGPYDTLYWPGLGPAVYRIPPP
                     RPRDLAAAITEAAVESTWYHPHRHGTVTAVVEAPMWGVAAVEDDSPPADRDAVLRAVSR
                     TLRHETRLLEHVLARVRPHLPAAPDTARLLAPVHDYLLVCPGLADAWDPGAGDPIRPLP
                     PLNTAHLAALRIAGRRIAVRTAGLLRQLVAGSGHDPAGALPELDALIDGWCADYHDGFG
                     ARWIPVARQVEYQTRVVLAAFELASRPAPAPARSGEPDWGTGAAVPMHRE"
ORIGIN
        1 tcgaccttgt cgaaggtgct ggcgtcgcgg ccgatctcga tgttgttgaa cgaggcgtca
       61 ccggtgatgt cgtccgagtc gatggccagg ttctccacgc tcaccttggt gcccttgtcg
      121 cccgcggtga ggacgagctg gatgccgccg aggtcgacgc tctggcacag gctggtcagc
      181 ttgcccgact tcaccaccga ggtgacgacc aggacctgac cgccggtctc accctcgttg
      241 gggctgttct cgatcatgtg gtccaacgag ccgaactgcg cgaaaccgtt cccttcgagc
      301 ttgtcggcgg tcaccacgaa cggcatgccg gagatcgcga actgcacacc cagggctccc
      361 tgggcggtga gcaccgcgag gccggcggcg acgcaggtcg cgggtacggc catcacggcc
      421 gcccggcgca gccggacccg accgcgcctt gctgcggaac cgctttccgg gttcccgggg
      481 atgttctcgg cggacgacgt gacgtccgag gacgaggcca tgtctgctcc catgggcata
      541 gtcatgcggt ttgggcttca gtggcgtgtt gtcctggcgc ggacagcggc tgccgcgcac
      601 gtctcctcgc aactcccgga agccgcaagg gctttctcgt tacgcgtcag tagccgacga
      661 ggaagttacc gatggttaca cctcagggtc aagggagatg tggaaaaagg gtgtgcgaag
      721 tgtgccgcct gcggaccggt gcaccggccg acccctcgca tatatctgcg cgggccacca
      781 acttccgtgc aactgcttga cggtgacggt ccatcaggtc tacaactctc ggtgactcag
      841 cccggatccg tggcgccgga tccgcagcgc ggcgagcagc tctccgcgct cccggacccc
      901 ccggtccggc cgtcccttcc aaccgacggc cggacctccc gtcaatacgg gtaccacctg
      961 cccgggcatc cagcacgggc cctcacgcgc cccgagtccg attcccgcac ggcgccgcca
     1021 cggccgcctt tccccctgcc ggccgtgctc gtcgccacct ccgctgccgg tccgtcacgt
     1081 acggagaagg cgttccgggc cggcaccgga cgggcgtcgg cccgcgaccg gcaactcccc
     1141 tgagcacacc tctcggaaca cctcaaggaa cacctctcag agcgcctcag aaaagccctg
     1201 aggcaccccc acccgagaaa cgaggcaccc gcatgcgcac tcgccccctc ctcgccctcg
     1261 ccgccaccgt cgccgccctc tcgctgacgg cggccacccc ggcctccgcg gccgacccgg
     1321 ccgtcctcac cacggccaac ggcgacgtcg cggtcggtga cgtcctcacc gcctccctcg
     1381 ccagcggcac caacgccacc ctctactcct ccgccaccgg caccagcggc gtctcctgcg
     1441 cctcctcggg cttcaccgcc accgtcaccg ccaaccccac cgcccccggc acggccaccg
     1501 agtcgctcac cggccacacc ttcggcaact gctcggcgaa cgtcgtcggc gtgctcggcg
     1561 tcaccagcat cacggtcaac aacctgccgt actccacggc ggtgtcctcc gccggcaccg
     1621 tcaccgtgac cccgccggcc ggctccgtca tccagacgac ggtcgtgctg cgcaccctcc
     1681 tcggcagcat caactgcgtc taccgggcgc ccagcctgac cggcacggcg agcaacgccg
     1741 acaacagcat caccttcacc ggccagcagt tcaccaagtc gtccggctcg tcgctgtgct
     1801 tcgcaaacgg ctacttctcc gccaagtacg ccccggtgac cgccgccggc ggtgcagccg
     1861 tcaccgtcaa ctgacccctg tagagggact cgggaaaccg gttcgacgaa cgcaccgaac
     1921 cggatgagaa acaccgtttc agcgccgtcg caggcgcagg accagggtgg cgccgccgat
     1981 gagcaccagc accgcggcgg cgccacccgc cagcatcggc gcggacggcc cggagccggt
     2041 cccggaggcg gtggccaccg gggtgctcgc aggcgtggcg gcggccggag cgccggacgc
     2101 cgtcgccgct cccgacgcgg gggcggcgga cggtgtcgta ccggctgacg tgccggccgt
     2161 cgtgccggac gggaccgagg ggtcggcgga cggaggcttc ggcgatccgg ccgtggccgc
     2221 cgacggcgag gccgccgccg cggccttctc cgggaacacc acgtcggagc acgagtagta
     2281 ggtgtccggc gtgctgctgt tctgccacac cgtgtacagc acctggcgtc ccgtgcggtc
     2341 ggcgggcagt tcggccgtga gccggtaggc gccgtcgcgc agcaccgggt ccttcacctg
     2401 ggcgaacggc cgctcgggca gatcgttcca ggtgagcggt tgcgacgggt cgtaccccgg
     2461 cttcgtcaga tagaacctga acgtgcccgt gtgcgggatc gtcgacacgt acgtcatgcg
     2521 cagcgtcccg cccgatgtca ggcgggtcga cggccagtcg gagcgcgcga ggtcgagtcc
     2581 ccggtaggcc ggcagtccgc cgctgcacag ctgcccgtcg gggatcgtgc tccggtcgcg
     2641 gccgttcacg ttcgccaccc gcaggttgtc ccaggccgtg aagggcgcgc cgttggcggc
     2701 cacggcggcc cggcaggcgg ccgacccgga cggcggtccg ccgtcggggg agcaggcgtg
     2761 gacccggctg accggggtcg tgggcgcgcc gtgcgcctgc gccggtgccg ctgcccacag
     2821 cagcaccggc aggagcgggc tcagggcggt ggccgccagg gcggcggtgc ggtctgtggt
     2881 cgtgcggcgc atcggggacg tctcctcggc cggcgcggga acggtgacga cgtccagtac
     2941 gcggcggcgg cccggcgcgt tcaccacgcc gacacaccgg gcgtctcccg agcaaacccg
     3001 ggcatccgcc gtccagttgc ccctgccgag ggtggagttc cggccggatc gagggtttcc
     3061 cccgtatccg aacaaccgtt gccctgccta tcgttccacc acagctgacc cacaggtaac
     3121 ccctggtggg gcggctaccc gcccggccgg ccgtcgcgta gctcctcgat tcaccccccg
     3181 ccgcttcgac gacgaagcga atcgaccgag gctcccccct gctcggagcc ggccacgaaa
     3241 ggcacgcccc cttgcgcacc tctcccgctc tcggacggaa gctgatatcc gtcgccgcgg
     3301 tctccgcggc cctcctcacc gccgccacca ccgcctcggt cgccgccacc ccggacggcg
     3361 cgtcacggga ggccgccgcc gtcccggccg cccagaccga ggccgcgccc ggcaccccgg
     3421 ccgagcgtct catcgtcggc tacaagtccg ccgctgcgga ggccaggtcg aaccaggccg
     3481 ccgaggccga tgccgccgcc aagggcgagg agaccggcga ggacctcgac ttcgagcgcc
     3541 gcctgggcac cggcgccgcc ctcgtcgacc tgggctccgg cctcaccggc gcggacgtcg
     3601 ccgacgtcgt cgcggagtac cgtgccgacc cgcaggtcgc ctacgtcgta ccggaccggc
     3661 tgaacaccgc gaaggccgac ccgaacgaca ccgagtacgc caagcagtgg gacctgtacg
     3721 aggccacggc cggcatgaac gtgcccggcg cctgggccac cacgaccggc accggtgtga
     3781 cggtcgccgt catcgacacc ggctacgtcg cccacacgga cctcgccgcg aacatcgtcg
     3841 gcggctacga cttcatcgcc gacaccgccg tctcggtgga cggcgacggc cgcgacagca
     3901 acccggccga cccgggcgac tggtacaacg ccaacgagtg cggctccggc gtcccggccg
     3961 gctcctcctc ctggcacggc acccacgtgg ccggcaccat cgccgccgtc accaacaacg
     4021 gcaagggcat cgcgggcatc gcccacggcg cgaagatctc cccggtccgc gtcctcggca
     4081 agtgcggcgg ctacgactcc gacatcatcg acgccatcac ctgggcgtcc ggcggtacgg
     4141 tttccggcgt tcccgccaac accaacgtcg ccaaggtcat caacatgagc ctcggtggcg
     4201 acggcgcctg cacctcggcc acccagagcg cgatcaacgc ggccgtgtcc cgcggcacga
     4261 ccatcgccgt ggccgccgga aacgagaacg acaacgtcgc gaaccactcg ccgggcaact
     4321 gcaacaacgt catctcggtg gccgcgacca gccgcaccgg cgccaaggcc tcgtactcca
     4381 actacggttc cctcgtggac atctcggcgc ccggcggcca gaccagcacc ggcaccgcga
     4441 acggcatcct gtccacgctg aactccggcg ccaagacggc gtccaccgag tcgtacgcct
     4501 actaccaggg caccagcatg gccaccccgc acatcgcggg cctggtcgcg ctgatgaagt
     4561 cggcgaactc ctcgctgacc ccggcgcaga tcgagacggc cgtcaagagc aacgcccgtg
     4621 ccctgcccgg cgcctgctcc ggcggctgcg gcgcgggtct ggcggacgcg gccaggacgg
     4681 tgcaggcggt gagcggctcc ggcggctcca cggggggcac caccttcacc agcaccaccg
     4741 cggtcgccat tccggacaac ggctcggccg tcgagtcctc gatcgccgtc accggccgta
     4801 ccggcaacgc gcccacggcc ctccaggtgg gcgtggacat cacccacacc taccgcggtg
     4861 acctggtcat cgacctcgtc gccccggacg gcacggcgta ccgcctgaag gcgtccagca
     4921 cctcggactc cgcggacaac gtcgtgacca cctactcggt gaacgcctcc agcgaggttg
     4981 caggcggcac ctggaagctg cgggtgcagg acgtggccgc gcaggacacc ggccgcgtca
     5041 acagctggaa gctgaccttc taggtcggga ggctgtacgc gggggaagcc ctcgcagccg
     5101 tacgaacggg cgggccggcc ggtgtggatg gacaccgacc ggcccgccgc acgtccgggt
     5161 caggaagcca cgcgctgttc cagcgaggcc agcacccgcg tgccccggtc ggcacgggcg
     5221 tcgaggccgg ggagcagacc cggtaccgcg atgctgggca ggatgtgcgc ccacatcacc
     5281 gacagccggt caccgagatc ggcgcggtcg gtcagcgccc gggacatcaa ctggacgccg
     5341 gtgaaggtgc ccaccagcag gtcgaccgtc tccgccggct tcaccgtggg caacaactcg
     5401 ccccgctcac cggccagttc cagcagttcg gtcagcgcct gtgcccactg gcggaacggc
     5461 tcgccgtgat cgaccccgga cggcgtctcc tggtccaccg ccagccgtac gctgccccgc
     5521 agcagggcgt tgtccagcaa ccgacgcgcc accacgaagg tcatgtcgac gatctcctgg
     5581 agcttgcacg gctgcggcgg gaccgccccg aagggcacct gctcgttcag gaccgcctgg
     5641 gccagggcct ctttcgacgc gaagtggaag tacagggcgc ccttggtgac ctgggcgcgc
     5701 tccaggacca tggcgatggt ggtggaggtg tagccgtgct cgtcgaacac cgcgcccgcc
     5761 gcttccacga tcgctctgcg cgtcctgatc gcgcgctcct gtttcgccat tgagagcccc
     5821 ttcacggcac cgagccggcc gtccccgcag tcggatgcgg attcggtccg atcataggat
     5881 gccgtcgact gatctcattg aaaacaaacc ggtcgcctcg tactctaacg ctcaccgagc
     5941 ggacggttcg ccgtctgccg tggccttcgg gggaccgtag ggagagagat gactcgaccg
     6001 cggcagcttg ccgacacgcc gtccctgacc gcaaccgttc cgcgccaact cgtccaccgc
     6061 gccgccctcg cggagacctt cctcaccggc tggcggcgaa ccggggccga caggttcacg
     6121 gtgtccgcgc agtggccgcg cgcgcacggg ttacacgtgt cgcccgattg gtccgcgtac
     6181 gacccgctgc tcgtcgtcga aacgatcagg cagagcggca cattggtcag ccacaccgag
     6241 tacgaggtgc cgctcgacca gcagttcgtg ctcaaggagt tccacgtcac gacggagcca
     6301 tgggcgttga ctctcggacc gcggccggcc gaacccgagg tcgaactcgt cttcaccgac
     6361 gtccagtacc gcggccgacg tcccgtcggt gcccgctaca ccgcgcgcgt ggtgcgcgac
     6421 ggcaccctcg tcgccgccgc ggacgtctcc ttcagctgcg tcagcgaacc cgtctaccag
     6481 cggctgcgcg gcggtcgcac cccggacacc gtgacggccg tccccctacc gcccggcgtg
     6541 cccgccgacg ccgtcgaccg ggctctgccc acggacgtcg tcctcgcccc caccgaccgg
     6601 ccggaccgct ggcaactgcg agtaaatacc gcgcaccccg ttttcttcga ccatcctctc
     6661 gaccatgtcc ccggcatgct cctgctggag ggagcccgcc aggcggccct gctggaaaca
     6721 cccggtaaac gggttccgac ggcttatcac gccgttttcc acaggtacgc ggaactggac
     6781 gtacccacct ggatagaggc aaaggccgcc cacgacggcg acgtgcaagt cgtcggcgta
     6841 caaggggagt ccacagtctt tgcgtgtctc gtcggtaccg ccggaccgtg aactgttgtt
     6901 tactgggggt gagaaacaaa cggcatgacc cgttctttac gcccccagga gtgtccagtc
     6961 gatggcgagg caactacgtg cggagcagac ccgcgcgacg atcatcaggg ccgcagccga
     7021 tctgttcgac cggaacggct acgagtcgac cagcctcagt gacatcgtcg agcgcgccca
     7081 ggtcaccaag ggcgcgctct acttccactt cgcggccaag gaggatctcg cccaggccat
     7141 cctggagttg cagtcccagg cctcgcgccg ggtcgccggt gagatcgacg accgcggtta
     7201 cccgtccctc gaagccctga tgcgcctcac cttcggcatg gtgaggctgt cggtcgaggg
     7261 cccggtcgcc cgggccggcc tccgcctggc caccggcggt gtccccgtac gcccgcccgt
     7321 gccccacccg ttcaccgagt ggatggagct gatgtcccgc cgactcgtcg gggcggtgcg
     7381 ggagtccgac atccatcccg acgtcgacgt ggacgccgtg gcccactcgc tggtctgttt
     7441 cttcgtcggc acccgcgtgg tcggccgctc ccgcgagccc ggcacccggc tcccgcgccg
     7501 cctggccgag atgtggcacg tcctcatccg cggcctcgtc cccgtccccc gccgcccccg
     7561 ctacctgagc ctcgcggccc gactggaacg ggaggtcatg gcggcggcgg tgtgagcgac
     7621 ggggttgccc gcgcgtccgt ctggcgacgg gccgtccgcc tggtgacgtg cgcgtccatt
     7681 cgacgacggg ccgtctgcct ggtgacgtgc cacttgtccg gcgacgtgcg tgtccgttcg
     7741 gcgacgggcc gtccgcctgg tgacgtgcga tctgagtgtc cgcccggcga cgtgggcgtc
     7801 cgcctggcga cgtgccactt gtctggcgac gtgcgtgtcc gttcggcgac gggccgtcgg
     7861 cctggtgacg tgcgatctga gtgtccgccc ggcgacgtgg gcgtccgcct ggcgacgtgc
     7921 gatctgagcg tccgcccggc gacccgcgcg tccgcgcccg ccgcttgggt acggccaact
     7981 cgcggttcac gggcctcgct cacggcggac ccgtggccca taggccggcg tgcggccgac
     8041 ccgtgggccc gtgagccggc gtgaggctga tcccgcgctc cgtgcctcgc gtgtgcgcga
     8101 tcccgcggtt tccgtgtgcc tcgcgtgtgc gcgatcccgc ggctttcgtg tgacgcgcgc
     8161 gtgcggtcgc catcggagcc gacctcactc gtgcacagcc gacctcgcgg cccgcggcgc
     8221 cctcgaacgg ctgcccctga gggcggccgg ctggctggtg cgcgcggtgg gccgacttcg
     8281 cggcccgccg cccgcgccac tcgcgcacgg cggaccacac ggctggtgaa gcgcctacgc
     8341 ctgacttcgc ggcccgcgtc acacccccgg ctgatcgtgg cacctcgcgc ccgtgccgac
     8401 gcccatgccg acgcccgcgc cgaggcccgt ggcggcacag gtggccgcac ccacctccgg
     8461 tccgcgctga ccccgacccg ccgctccggc acctctgctc cggtccgcac tcacggtcga
     8521 cccccgtgcc ggcacctctg ttccggtccg cgcccacggt cgacccccgc cgcccacgtc
     8581 accccacccc tccccacgtc acccctcgcc acatcacccc cgtcccacgg cacccccgcc
     8641 ccgccgcccc accccgcgat accgtgatcc gcatgtccga cacccccatg ccgcccgttc
     8701 cgcccgtgat cctgggcgac gagcccggct cctttgcgcg cggtgtcctc gccgagcggc
     8761 accccgcgat catccggcgg gtgcgggacg ccttccccta cggacccgac gtccggcggg
     8821 ccctggacgc gctgctgacg agctgcgtcg agggcgtgat cgagccgctc cccgccgacg
     8881 cgcacgaccg ggaccgctgg cgggcctggg ggctggacgg gtacgcgggc cgctcctggt
     8941 acgaggtgcc ctggctgtgg tcggagagct acttctaccg cctgctcctc gaaaccgtcg
     9001 gctacttccg acccggcccc tggcagggtc tcgacccgtt ccgcccgttc aagctcgccg
     9061 aactggacgc ccccgagacc gacgaggaac tcgccgcgct cgacggcctc gaaggccgcc
     9121 cggagccgga acgggcacag gccctgctgc acggctccct ctggggcaac cgcgccgacc
     9181 tcgggttccg actctccgac gcgggcgcgc gggacagggc cgccgtcccc ggactcgtcg
     9241 ccgacgacag cgagaccctg tgggcgctgc tggcgccccc gcaggccgcc gacggcacgc
     9301 tgtgcctggt cgccgacaac gccggccgcg aactcatccc cgatctgctc ctcgccgccc
     9361 acctcctcgc ccacgggcgg gccggccggg tcgtcctgca cgtcaagccg tacccctact
     9421 acgtctcgga cgccacgacg gccgacgtcg tcgacgcgct gcgccgcctg acggccgctc
     9481 cggggacggc cggcgggtac gggcggcggc tgtgggcggc gatggcggac ggcacgctga
     9541 cggtccgcgc ccatcccttc gccgcggccc cgctgccgta cgagcggatg ccggacgatc
     9601 tgcgtgccga gttcgtgggc gccgccctga cgatcgtgaa gggtgacctc aactaccgcc
     9661 gtctggtggg cgaccggctg tggccgccga cgaccccctt cgcggacgtg accgcccact
     9721 tccccggccc ggtcgtggcc ctgcgcaccc tgaagtcgga cgtgatcacc gggttgtccg
     9781 ccggtaccga ggccgcgctg accgccgccg agggccggag ctggcggacc ggcgggacac
     9841 acgcgctgat ccagaccagg aagtgagcgc cgcgcgggcc gcagcgtcag cccgctgtca
     9901 acagcgcccg attcgcaagg attcgccccc ggttcacgcg atggtgtgat catgtgccgc
     9961 gccacggatg acggttggcg cccccgggta gggcccggcc atgacgcagc cgttcgaact
    10021 cccgcacttc tacatgccgt atcccgcgcg gctcaacccg cacctcgacg aggcccgcgc
    10081 ccactcgacg gcgtgggcgc gcgagatggg catgctggag ggctccggca tctgggagca
    10141 ggccgacctc gacgcgcacg actacggcct gctctgtgcc tatacccacc ccgactgcga
    10201 cggccccgcc ctgtcgctga tcaccgactg gtacgtgtgg gtgttcttct tcgacgacca
    10261 cttcctggac atgttcaagc gcaccccgga ccgggcggcc ggaaaggccc acctggaccg
    10321 gctcccgctg ttcatgccgc tcgacctggc gactccggtg ccgaaaccgg agaacccggt
    10381 cgaggcgggc ctcgccgacc tgtgggcgcg cacggtaccg gcgatgtccg ccgactggcg
    10441 gcgccgcttc gccgtcgcca ccgagcacct cctcaacgag tcgatgtggg agctgtccaa
    10501 catcaacgag gggcggatct ccaaccccgt cgagtacatc gagatgcgcc gcaaggtggg
    10561 cggcgccccg tggtccgcgg ggctcgtgga gtacgcgacc gccgaggtcc ccgcctccgt
    10621 cgccgggtcc aggccgctgc gggtgctgat ggagaccttc tccgacggcg tgcacctgcg
    10681 caacgacctg ttctcctacc agcgtgaggt ggaggacgag ggcgagctga gcaacggtgt
    10741 gctcgtcctg gagacgttct tcggctgcac cacccaggag gccgccgaca ccgtcaacga
    10801 catcctcacc tcccgcctcc accagttcga gcacaccgcc gtgaccgagg tgcccgcgct
    10861 ggccctggag aacggcctcg ggccggacga ggtggccgcc gtcgccgcct acaccaaggg
    10921 gctccaggac tggcagtccg gcggccacga gtggcacatg cgctccagcc gctacatgaa
    10981 caagggagcc ggctccacct cgccctggga gaagctgacc cgccccggta cctccgcagc
    11041 cgacgtcggc gccctgctcg cctcggccgc cgcggaacgc atgcgcgcgt acacgcacgt
    11101 gccgtaccag aaggtcggcc cgtcccggct gcccgagttc cacatgccct tccaggtgga
    11161 gctgagcccg cacctggacc gggcccgcca caacctggtc gggtggacgc gccgtatggg
    11221 catgctgtca gaaggggtgt gggacgagga caagctcgcc tcctgcgacc tggcggtctg
    11281 ctcggcgggc ctggaccccg acgccggccc cgaggccctc gacctcagcg cctcgtggct
    11341 cgcgttcggc acctacggcg acgactacta cccgctggtg tacggccacc gtcgcgacct
    11401 ggccgcggcc cgggtcacca ccgcccgcct gtcggcctgc atgcccgtcg acggcgagga
    11461 gaccgtcgtc ccgctgaacg ccatggagcg gtcgttgatc gacctgtggg cgcgtacgac
    11521 ggccgggatg acccccgacc agcggcgcac cctgcgcgcg gcggtcgaca gcatgacgga
    11581 gagctgggtg tgggagctgt ccaaccagct ccagaaccgc attcccgatc ccgtggacta
    11641 cctggagatg cggcgcgcga ccttcggctc cgacctcacc ctgagcctgt gccgcatggg
    11701 tcagggcccc gccgtcccac ccgaggtgta cgccagcggc ccggtccgct cgctggagaa
    11761 cgcggccatc gactacgcct gcctgctcaa cgacgtcttc tcgtaccaga aggagatcga
    11821 gttcgagggc gaggtccaca acgcgatcct cgtcgtgcag agcttcttcg gctgcgacta
    11881 cccgaccgcg ctcggcgtcg tccacgacct gatgacccag cgcatgcagc agttcgagca
    11941 cgtcgtcgcc cacgaactgc ccattctgta cgacgacttc ggcctgtcgg cggaggcccg
    12001 cgaggccatg cgcggatatg tgaccgacct ccagaactgg atggccggca tcctgaactg
    12061 gcatcgggtg gtggaccgtt acaaggactc ctacctgtcc cgccggtccc acggcttcct
    12121 gcccgaccgc ccaccggccg tccccgccct gccggtcggc tgaccgcgca cggcgaccgt
    12181 cgcggcgttg ccgctcgacc gaccgcccac gcggaccgtg cccgtcgtcc ggggtgcggg
    12241 gtgtccgtca ccggggtcgt gcccgtcgtc cggggtgcgg ggtgtccgtc accggggtcg
    12301 tgcccgtcgt ccggggtgcg gggtgtccgt caccggggtc gtgcccgccg tccggggtgc
    12361 ggggtgtccg tcaccggggt cgtgcccgcc gtccggggtg cggggtgtcc gtcaccgggg
    12421 tcgtgcccgc cgtccggcgt gcggagtgtc cgtcacgcgg atcgtgcccg ccgtccggcg
    12481 tgcggagtgt ccgtcaaacg gaccgcgccg ccgtccggcg cgtcgcgtgc ccgaccgcgg
    12541 ctcgtgccag tccccggagc atggggtgcg ggcgtgagcc gtcgccgtac agctccggct
    12601 ggaagaggga ggccaggaag aaggggtggc cggggagttc ggccatccgg acctggcccg
    12661 ccgcgtcccg gccggagaag cgcaggccgt gcgcgaccag ggtgtcgaag tgccgggaga
    12721 ggccgtaccg gcaggagtag cgctcgaccg tggactctag gccgatcacc tcgcgggcca
    12781 gcgagcccgg ctccagcagg acggtgtcct cgtggccctc cagtgagcag gccagcggtt
    12841 ccaggagagg gtcctcggca cccgggtcgt tctccgcgtg cgccgcgtgg gccagcccgc
    12901 aggcgttgcg ggcgaactcc agcagcgcgt gctggaaccc gccgcaggtg ccgaggaacg
    12961 gaatgccctc ctcgcgggcg gtccggatcg cggcgaggac accggcctcg ctgcggtacg
    13021 ggctgcccgg caccacccac accgcgtcga agccgcgcac cgcgtcctcg gcctccgcgt
    13081 cggccgacgg gatccagtac gcgtcgagga ccagccggtc ccgggcggcg agggcgtcga
    13141 gcaggagcgg gatccgggtg tgcgagacga cgttggggga gtggtcgccc accagggcga
    13201 ccttggcgat ccgggcggtg ccggcgatct gagcggtgct gtcggtcatg ggtctcatcc
    13261 tcggagcggg ccccacttca cgtccaacga tgattactgc acttccgata agcagaactg
    13321 atgcgaccct gtgggcatgg acccgcacct cctgcgcacc tacgtcaccg tggcccgtct
    13381 cgcctccttc tccgaggccg cgcgcgatct cggctacacc cagtcagccg tgtcccagca
    13441 catcgcggcc ctggaacagg acctcggcgc gccgctgctc acccgccggc ccgtcgcccc
    13501 cacggcggcc ggcgagcggc tcctcgaaca cgccgggccc ctgctgctgc gcctggcggc
    13561 ggcccgcgcg gacgtcgtgc gcatggccga cgcccccgac cacggcctga ccctggccgc
    13621 ctccgcgacc gcgctcaccc cagcgaccct cgccgcgctg ccgtccgccg gtgtgacact
    13681 gcgggtgctg gcccgcgacg aggtgccggc cgccgtcgcc gcgggcaccg ccgacgtggg
    13741 cctcgtcgac ggcctggccg cccccagcga ccccctccgg ctgcccgacg tggcaccgct
    13801 cacgacccac ggcgtcgggg aggaaccggt cggcgtcctg ctgcccgccg gccatcccct
    13861 ggcccgccgc accggactgc gcctcgggga cctcgccgac gcccgctgga tcgacgcccc
    13921 cgacacgggt ctgccgctgc cccagctccg cgccgcgaac ggcggccgcg gcttccgccc
    13981 ggcgctgcgc tacgacggca ccgacgtccg cgtcctggcc gcgctcgccg ccgcgggcca
    14041 cggcctgacc ctgctgcccc gctcggcgac ggccgacacg ccgggtgcgg tggccgtgcc
    14101 gctcaccgca ccgagggtcg tccaccgggt ggaactcgtc cacgccggta cgccgacggg
    14161 tgccgcgcgg gccctggccg cggcgctgtc cccgcgcgcg tgagcccggt tgcgcggcgg
    14221 tcgtaccgct gttgaccgct ggtcagtctc actcgttcgt ggcttgtgac gctccggtgc
    14281 gacgggtagg gcaccggacg gaggcgatcc atggaacaga ccgcgttgcg tcccaagccc
    14341 atgcccggcc aggagcccgg cggaggcccg ccgtccgacg gccggcccca ccacccgcac
    14401 gccgcccgcc gtcgtggccg acatctgacg accctgctgt ccggcctgtt cgtcggtacg
    14461 gtcctggtgc tgtccggcgt cggcctcggc accgtgggcg ccacggtgat cggcgcgagc
    14521 aagctcgccg agctgcaacg gcaggcgggc ggggccgcac cgggtgccgt gtcacaggcg
    14581 ggcccgagtc cgtccgctca ggactccccg gcggcggcgc ccgccgacgc caccctgggc
    14641 ctggagatcg tggacgccga gaaggcgggc gccgagatcg tcgccgtcca tgtgcccggc
    14701 cctggctatt cggccggtct ggtgcgcggg gacctcgtac tgcacttcgg cagggtccgg
    14761 atcgactcgg cgggggatct cgcgcgtgcg gtcgacgagg cgaggccggg ccgggagatc
    14821 aaggtgacgg tgcgtcacaa gagtggcggg tatcagcagt tgacggtcgt gccggggatc
    14881 gtcacctgac ggcccggtcc gcgcgagggt gcgccgccgg actcagacga ccacccggaa
    14941 gtggctcgtg agccgccggt cctcgtccag gacgtggaac gcgagcccga ccggagcctc
    15001 acggtcggcg atctcctcgc cctcccaggg cagccgcagc gtccatgtca cgccggggcc
    15061 cacgaccagc ggccgcccgg cgaaggtggt ggcggccggg ctgtgggcgt ggccggtgat
    15121 gatcccggcg atctccggcc ggcgctccag cagcgcggcc agccggccgg ggtcacgcaa
    15181 ccggtagccg tccggcaggg gatggtgcag cgacaccggg gggtggtgga aggcgagcag
    15241 tgccggcacg tccccgtcca gctcgtcgag ggtctcctcg atccaggcgt acgtctcgtc
    15301 cgccagggcc ccctcgtcct cgcccgggat gctggagtcg cacatcagga ccgcgcctcc
    15361 gtcgaacacc tggacgctgt tgaccggccc gtccgcggcc ggccgcccga gcagggcctt
    15421 gcggtacggg gcgcgacggt cgtggttgcc ggggcaggtg agcaccggcc agggagtgcg
    15481 ggggccgtgc ggcccgagga tgcgtgcggc ctcctcgtac tcggcctccg tcccgtggtc
    15541 cgcgatgtcc ccggtgacca gcagcgcgtc cacccgcccc ggcaggttgc ggagccgctc
    15601 gcacacccgc tcggcgcgct cggtggcacg tgcgctgccg tccaggtgca gatcgctgat
    15661 gtgggcgagt acgagcacgg agtcggcctc ccgaagtgga ttaatgctta tcgaatacac
    15721 aaccattaga tctgacgacg agatccaacc atgagatccg atgggcaggc aatgcacacc
    15781 cgtcaggggg tggcgagtgg acgttcccgc gaaaccccgt cgaccgggtc gcgccgcccc
    15841 tgccgaccgg gcaggatgct gcccgtagtc accacgtcct tccagggagg cccggatgac
    15901 cggccgtacg cccgcgcgct tcaccgccga cgactaccgg gcccgcatgg agcgggccgt
    15961 ccgagcggcc gccgacgcgg ggctggccgg tctgctcgtg gcgcccggcc cggacctggt
    16021 ctggctcacc ggctacgcgc ccccggcggt caccgaacgg ctcaccctgc tcgtcctcac
    16081 ccccgaccgc gaccccgtcc tcgtcgtccc ggcgctggag gcccccgacg ccgccgaggc
    16141 ggtcggcgcc cccgcgctca ccctgcggga ctggacggac ggcaaggacc cctacgccgc
    16201 caccgccgcc ctcctggaca ccggcaaacg gttcggcgtc agcgacaacg cctgggcgct
    16261 gcacctgctc cgccttcaga aggccctccc ggacagctcc tacgcctccc tcaccgaggc
    16321 cctgccgatg ctgcgcgccg tcaaggacgc tgccgaactg gagctgatgg cggccgcggg
    16381 agcggccgcc gacgcaacgt acgaggagat ccggaaggtt cccttcgccg ggcgcaggga
    16441 gtccgaggtc ggcgccgacc tggccgacct gctccgccgc ttcgggcact cccaggtcga
    16501 cttcaccatc gtcgcctcgg gcccgaacgg agccaacccg caccacgagg tcggtgaccg
    16561 cgtcatcgag cacggcgaca tgatcgtcct cgacttcggc ggcctcaagg acggctacgg
    16621 ctccgacacc tcccgcaccg tccacgtcgg cgaacccacc gacgaggaac gccgggtcca
    16681 cgatctcgtc cgcgaggccc aggaggccgg cttccgcgcc gtgcggcccg gcgtcgcctg
    16741 ccaggagatc gaccgcgccg cccgagccgt catcgccgac gccgggtacg gcgagtactt
    16801 catccaccgc accggccacg gcatcggtgt caccacgcac gaaccgccgt acatgatcga
    16861 gggcgaggag cagcccctcg tgcccggcat gtgcttctcc gtggaacccg gcgtctacct
    16921 gcccggacgg ttcggggtgc gcatcgagga catcgtcacc gtcaccgagg acggcggccg
    16981 gcgcctcaac gacaccacgc gcgagatggt catggtcgac tgaaacccac cacgagttcc
    17041 ggcacccacc cgaacggcta cggcgcgacc atgacccagg catccacacc caccgcggac
    17101 accgtccgcc ggctggtccg cacgctcctc gaggtcggcg gcgagggcgg tcccggcccc
    17161 gaggtgcggc ccgtcaccga ggagggcggg cacggcacct ggtgggtcgg cacccgccac
    17221 gtcctgcggc tggcccccga ccgcgaggcg accgtccgca tgcgccgcga actgcgcctg
    17281 cgtgacctcg tccggccgca cgtaccggtc gccgtgccga cctccgtcgc gcacggcgaa
    17341 tggtcccccg gcctcaccta caccctcgac accaaggtgc ccggcggcac cgccgaggag
    17401 cacgacgtgt ccgccgtggg cgaggccgac ctggccggac tgctcggcgg actgcgtgag
    17461 gtaccggccc ggcaggccga gacggtcggc gtgccgcgcg tcgccccgcg ctccctggag
    17521 gcactgcgcc ggatggccgt ggccgccgcc caacggctcg ccgacgagga cgagttcgac
    17581 cccgcccggc tgcaccagct caccccgccg ggcgccgtcc agctcgccgc ccagcccgcc
    17641 accgccgtcc tcgtccacca caccctgcgg ggcgagcacc tcgtggtcgg cgccgacggc
    17701 cgggtgcgcg gcgtcctcga ctggaccggc gcggtcgtcg gcgacccggc cgaggacatc
    17761 gccggcctcg ccctcgccgt cggctccggc gccgccgtcc gcgccgccac cctcaccggg
    17821 tacggcgccc gcgcctgcct gcgcggcctg tggctggccc gctgcgacac cgtcgtacgc
    17881 ctggccgaac gcctgaccgg ccacggcacc gagtccccgg ccctgctgcg cacccagctg
    17941 cgacgctcct gggaggcgat cctgctggaa cgggtgacgg agctgcgcga ggacggggcg
    18001 gacgactgac ggacccgccc gtccccgccc cgctccggcc ctgtgcggcc ctcagtcctg
    18061 ctccagcacc acgcacgact caccgggcag gcgcagcagc ccgtccgggc ccggtgcgtc
    18121 caccggttcc cacgcggcca gtacgcgtgc ggggcgggtg cccaggggga tcgccgccgg
    18181 tgcctcgccg aggttcacgg ccacccggat gtcgccgcgg cggaaggcca gccagcgggc
    18241 ctgcgtgtcg taggcgacct tgaggtcggc gaggtcgggg tcggtgaggt ccgcctgggc
    18301 gtgccgcagc gcgatcagcc ggcggtacca ggccagcacg cgcgcgtgcg gctcgcgctc
    18361 cggctccgac cagtcgaggc aggaacggtc ccgggtcgcc gggtcctgcg ggtcgggcac
    18421 ctcctcctcc gcccagccgt gcgccgcgaa ctcccgccgc ctgccgttcc gtacggcctc
    18481 ggcgaggtcc gggtcggtgt ggtcggtgaa gaactgccag ggcgtgcccg ccgcccactc
    18541 ctcgcccatg aacagcatcg gtgtgaacgg ggacgtcagt gtcagcgccg ccgcgcaggc
    18601 cagcaggccg ggggagaggg aggccgcgag ccggtcgccc tgggcgcggt tgccgacctg
    18661 gtcgtgggtc tgggagtagc cgagcagccg gtgcgcgggc agccgggtgt ggtccagccg
    18721 ccgcccgtgg gaccggtcgc ggaagctgga gtaggtgccg tcgtggaaga agccgccggt
    18781 gagggtcttg gccagcgcgg cgaacggatc gcgcgcgaag tcggcgtagt agccctggga
    18841 ctcgccggtc agggcggtgt gcagggcgtg gtggaagtcg tcgttccact gcgcgtgcag
    18901 gcccaggccg tgctcgcggc ggggcgtgat cagccgcggg tcgttcaggt cggattcggc
    18961 gatcaggaac agcgggcggc ccgtctccgc ggcgagcgcg tccaccgact ccgacagctc
    19021 ctccaggaac gggtacgcgc gcgtgtcggc cagcgcgtgc accgcgtcca gccgcagtcc
    19081 gtcgatctgg tagtcgcgca gccaggccag cgcgctgtcc agcaggaaag cccgcacctc
    19141 gtccgagccg ggcgcgtcca gattgaccgc cgaaccccac ggagtgtgat gggtgtccgt
    19201 gaagtacggg ccgaagacgg gcaggtaatt gcccgacggg cccaggtggt tgtgcacgac
    19261 gtccaggacc acgcccagcc ccagctcatg ggcgcggtcg acgaaccgct tcagcgcctc
    19321 gggcccgccg tacggctcgt gcaccgccca cagcgacacc ccctcgtagc cccagccgtg
    19381 ccggccgggg aaggggcaca acggcatcaa ctccacgtgc gtcacgccca gttcgacgag
    19441 atggccgagc cggtcggccg ccgcgtccag cgtgccctcg gcggtgtacg tgcccacgtg
    19501 cagctcgtac aggaccgcgc ccggcagcgg acgcccctgc cacgcggccc gccacgcgta
    19561 gcggccgtgg tcgacgaccg cgctcagccc gtccggtccg tccggctgac ggcgcgaccg
    19621 cgggtccggc cgcaccgggc cgtcgtccac cgcgaagccg taccgggtgc cgtcccgcgc
    19681 ctccgcctcg ccgctccacc accccggccg cgcggcgtcg cgctccaacg cgcttgtgac
    19741 gccatcgcac tggagcgtca cacgttcggc ctgcggtgcc cacacctcga actgcacgga
    19801 cggttcccct tcgtctgctc acagcctgct caccgtgatg tagcccgacc cgacccatcg
    19861 tgctccaaac gagatcgatc cgctgcgcca acaccccctt cgccgcgcat ctcgtggcgg
    19921 tgtcgcgacg gatcgcctcg ggcacgcgcg cggagccgcc gttccgcgtt tttctggaca
    19981 cccgccgttc actgcccgac aatcacgaac gtgacgtcgt cattcgagtt caacacgtac
    20041 cccgcgcgcc tgtccgacgt ggagcgcgac agggcactga aggtgctccg tgacggcgcc
    20101 gccatgggcc gcctctccca cgacacgttc atccggcgta tggaactggc gctcgccgcc
    20161 cgccgttccg aggaactcgc ggtcctcacc gcagacctgc ccagtgagaa ccgcttctcg
    20221 cgcgccctct tcggcaccgt cgaggccgtc tccggcttca ccgtacggct gcgcagggcc
    20281 tggcaggccg agcggctgcc caagctgctg ctgccgcacc ccggcaccgc tcaggccctg
    20341 cgcatcggcc gtgaccccgc cagcggcctc aggctgaccc acgacagcgt ctcgcgcgtg
    20401 cacgccgaac tcagccgcca gggcggcatg tggatcctgc gcgacctcgg ctcgaccaac
    20461 ggcacgaccg tcaacggacg ccgcgtcatc ggcgccgccg tggtccgcga gggcgaccag
    20521 gtcgccttcg gacggatggc gttccgtctc tccgtgaact gagtcccggt cggcaagtcg
    20581 agcgctccgg ggcggtgttg acgtccctca cgcgccatga ctcactgtgc gtacagtcgg
    20641 cactcccggt gaaccgacgg cgctcccgac gcggaggtgt gtcctgccgc cactcctgcg
    20701 ctacccgacc gcggacgaac tcgcggcccg cgcggccgca ctcgtcgccc gccgaccccg
    20761 cgacacccgc ctgcgccgcg tcggcgtctc gcgcgccggc acgcccctgt ggctgctctc
    20821 cgtgggccac ggcacccgcc aggccctgat cgtcgccgga ccgcacgcca acgaacccgt
    20881 cggcggtgcc accgtcctgc ggctggccga gcgcgtcctc gccgacccgc ggctcaccga
    20941 ggacgccgac gccacctgga acctgctgct ctgcctcgac cccgacgggc tgcgccgcaa
    21001 cgagggctgg ctgtccggcc cctacaccct gggccgctac ttccggcact tcttccggcc
    21061 cggtttcctg gaacagcccg agtggctgcc cgacggggcg caggccgcgg ccctgccgga
    21121 gacgcgggcg ctgctcggtc tccaggacga gctgaaacct ttcttccagt gttcgctgca
    21181 cggcgtcgac gtcggcggcg gcttcgtcga actcacccgt gacctgcccg gactcccgca
    21241 gcgcgtggcc cacgccgccg cccgcctcgg catcccccgc gaactcggcc cctacgacac
    21301 cctgtactgg ccgggactgg gacccgccgt ctaccggatc ccgccgcccc gcccgcgcga
    21361 cctggccgcc gccatcaccg aggccgccgt cgagtcgacc tggtaccacc cgcaccggca
    21421 cggcaccgtc accgcggtcg tcgaggcgcc catgtggggc gtcgccgccg tcgaggacga
    21481 ctcaccgccc gccgaccgcg acgccgtgct ccgcgcggtg agccggaccc tgcgccacga
    21541 gacccggctc ctcgaacacg tcctcgcgcg cgtgcggccc catctccccg ccgcacccga
    21601 cacggcccgc ctgctcgcac ccgtccacga ctacctcctc gtctgccccg gcctcgccga
    21661 cgcctgggac cccggcgcgg gcgaccccat ccgtccgctg ccgcccctga acaccgccca
    21721 cctggccgcc ctgcgcatcg ccggccgccg tatcgccgta cgcaccgcgg gcctgctccg
    21781 ccagctcgtc gccgggtccg ggcacgatcc cgccggggcg ctcccggagc tggacgcgct
    21841 catcgacggg tggtgcgccg actaccacga cggcttcggg gcccgctgga tcccggtcgc
    21901 ccgccaggtg gagtaccaga cgagagtcgt cctcgccgcg ttcgaactgg cctcccggcc
    21961 ggcacccgca cccgcgcgat cgggtgagcc ggactgggga accggggccg ccgtgccgat
    22021 gcaccgggaa tgaagcactt ccccacacac cgcatcctgg gcgccctgcc cgtcacggcc
    22081 gccctcctcc tcgccgccgt cacccccgcc cagtcctcgg cgccccgaaa ccccctcccc
    22141 ggcgacgggc tccggctgac cgt
//
