LOCUS       NZ_CP085432            26451 bp    DNA     circular CON 25-JUN-2024
DEFINITION  Priestia megaterium strain F20 plasmid unnamed1, complete sequence.
ACCESSION   NZ_CP085432
VERSION     NZ_CP085432.1
KEYWORDS    RefSeq.
SOURCE      Priestia megaterium (Bacillus megaterium)
  ORGANISM  Priestia megaterium
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Priestia.
REFERENCE   1  (bases 1 to 170970)
  AUTHORS   Sun,X.
  TITLE     Bacterial competition corelates with biosynthetic potential among
            closely related bacteria
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 170970)
  AUTHORS   Sun,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2021) College of Resources and Environment,
            Huazhong Agricultural University, Shizishan Street 1, Wuhan 430070,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 17-APR-2019
            Assembly Method                   :: CANU v. 1.7.11
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 328x
            Sequencing Technology             :: Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023824175.1-RS_2024_06_25
            Annotation Date                   :: 06/25/2024 06:00:53
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,444
            CDSs (total)                      :: 6,214
            Genes (coding)                    :: 6,101
            CDSs (with protein)               :: 6,101
            Genes (RNA)                       :: 230
            rRNAs                             :: 17, 16, 16 (5S, 16S, 23S)
            complete rRNAs                    :: 17, 16, 16 (5S, 16S, 23S)
            tRNAs                             :: 173
            ncRNAs                            :: 8
            Pseudo Genes (total)              :: 114
            CDSs (without protein)            :: 113
            Pseudo Genes (ambiguous residues) :: 0 of 114
            Pseudo Genes (frameshifted)       :: 48 of 114
            Pseudo Genes (incomplete)         :: 62 of 114
            Pseudo Genes (internal stop)      :: 19 of 114
            Pseudo Genes (multiple problems)  :: 15 of 114
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:50:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 117366
            Orig. end                         :: 143817
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP085432.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26451
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26451
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26451
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16451](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16451
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(202..217)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.75"
                     /tool="antismash"
     gene            908..1330
                     /locus_tag="LIT34_RS27770"
                     /old_locus_tag="LIT34_27800"
     CDS             908..1330
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016766081.1"
                     /locus_tag="LIT34_RS27770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27800"
                     /product="hypothetical protein"
                     /protein_id="WP_029321023.1"
                     /transl_table=11
                     /translation="MDMSNIAKWIPVPYFQIRQDGTILNSSNITHSYFQSTSSIWNIIY
                     KEDRNKAILMLSQITNSYPVTQYLILQTSNKLFMNFKCTIQWQDSIGHLVCTEAKNIKV
                     PSVLSVQKSLVNTQKRLEESEKHLNNVIKILDIRKH"
     gene            complement(1577..2203)
                     /locus_tag="LIT34_RS27775"
                     /old_locus_tag="LIT34_27805"
     CDS             complement(1577..2203)
                     /EC_number="3.2.-.-"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0019172 - glyoxalase III activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014458906.1"
                     /locus_tag="LIT34_RS27775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27805"
                     /product="type 1 glutamine amidotransferase family protein"
                     /protein_id="WP_053488458.1"
                     /transl_table=11
                     /translation="MQIKKVYIYVFNTMSDWEYGYLIAELNSGRYFRQGLAPLKVMTVG
                     VNKEIIKTMGGLSIQPDISLDECTLLDKDLLILPGGNTWSEEIHQPILKKVGEVLELGT
                     IVAAICGATDALANSGYLDSRKHTLNNLEYTKMVCPNYKGEKLYEVGPVVSDNNMITAS
                     GVAPLEFARDVLKKLDVFASNTLDSWYRLNKTQKSEYFFQLMSSI"
     misc_feature    complement(2273..2287)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.86"
                     /tool="antismash"
     gene            2428..3135
                     /locus_tag="LIT34_RS27780"
                     /old_locus_tag="LIT34_27810"
     CDS             2428..3135
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012259899.1"
                     /locus_tag="LIT34_RS27780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27810"
                     /product="IS6 family transposase"
                     /protein_id="WP_053488457.1"
                     /transl_table=11
                     /translation="MEKENVFKWKHYQPDLILLNVRCYLRYNLSFRDLIEMMEERGLCI
                     AHTTIMRWVHQYGPELNERVRRHLKPTNDSWRVDETYVKVKGQWMYLYRAVDSEGNTID
                     FYLSKARNKQAAKRFFKKALAFSHVSIPRTITVDKNPAYPIAIQELKKEKKMPEGIQIR
                     QIKYLNNIVEQDHRFIKKRLSTMLGLKTFRTAKAIISGIEVMHMMKKKQVYQEVKSVQN
                     QISFIHQLFVIAA"
     gene            3472..3981
                     /locus_tag="LIT34_RS27785"
                     /old_locus_tag="LIT34_27815"
     CDS             3472..3981
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016134870.1"
                     /locus_tag="LIT34_RS27785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27815"
                     /product="DinB family protein"
                     /protein_id="WP_053488456.1"
                     /transl_table=11
                     /translation="MNQRPSEEEYAWAIGEYIRLVPDGNIIDILLSQEKQMTELLASLT
                     ESHGAYRYAEGKWTLKEVVGHIADGERVMTYRLLRFARGDQTPLSGFDQELFMPPFGCW
                     STAQLAEDYRAVRQSTITLLRGLPAEAWSRKGTANNASITARALAYGIAGHEIHHMGVI
                     RTRYLS"
     gene            complement(5282..5890)
                     /locus_tag="LIT34_RS27790"
                     /old_locus_tag="LIT34_27820"
     CDS             complement(5282..5890)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002128205.1"
                     /locus_tag="LIT34_RS27790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27820"
                     /product="response regulator transcription factor"
                     /protein_id="WP_081113367.1"
                     /transl_table=11
                     /translation="MSIRTLLVDDHLLVMLGIRRLLESEEDIEIIDTVNDPSSLIEVVA
                     TTSPDVVVTDVRMKEFNGIELTKELLSKFPEIKVVILSGYDHEEYYNAAFKAGASAYIT
                     KERSAFDLANAIRQSNMGYILFSKNQISTKDFETLTSAEQKILLLISKDKTNYEISMDL
                     SISKRTVEYHISSIIRKLDVDSRVGAVVKGIKKGLIEDF"
     gene            complement(5862..8012)
                     /locus_tag="LIT34_RS27795"
                     /old_locus_tag="LIT34_27825"
     CDS             complement(5862..8012)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013060082.1"
                     /locus_tag="LIT34_RS27795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27825"
                     /product="ATP-binding protein"
                     /protein_id="WP_053488455.1"
                     /transl_table=11
                     /translation="MNKHNLLICLPLGTLYIIIFMANGYYLYLSDFRRFVDSATLNSFY
                     VTSVISVIFFSIGLFSFFKKQKSIVIKNFFLLTSVSGIAISTSVLSSQDIPVFKTIEII
                     SVFMLSYLLLSFFAHFPVSTKPNYVKIIIFSSLLFSTLSSVVYLICNYLGYVEHSKFFY
                     IYRVLLIGNLFFSIVGCIFLISLHLKTNSLKVRNQLYILIFGIVFSFGPLFLFNLIPGM
                     IFGESQIPFVYCLPSIIVFPLTTSYLLVKHEIIEVELEISKWINILIYYILNFLLFSIL
                     IKQFMHLSNRELFVICSVGLLSAWASIFLYKIGINTFIQKKTKNRENTDLNEIELFQTL
                     SKEKHAKNLAKIIGKVIHQKFDINGLCIVWNSNNIYHSLHETGIFQTMNQFNFLNEINK
                     LEKDILLVEDQTPSIHMHFEKYHLICFPIAINQLVQGVIVIGEKNNHTLFQGKEFIELK
                     ELICESADILSSAAILNINDKQIRRTKTRVQNWNQFNHQVIQSLEKERKRLSIFLHDEI
                     LQSLILQLNEVRIMQTKRNFSVTLLDEMDDQLEGMIYNIRKMCHDLHPIIVEDLGLEPS
                     LQSLKREFELNYSILIHVQFNCEFKIISKNHEIQVYRIIKELLNNAVKHSKGKNIKVLI
                     LEENGFYQCSVKDDGIGFDVPDNFFDFSKGNHLGLLTIHRQIAELNGSMRISSDKGQGT
                     FVTFTIPLDWEDKNEYTYATSG"
     gene            complement(7999..8961)
                     /locus_tag="LIT34_RS27800"
                     /old_locus_tag="LIT34_27830"
     CDS             complement(7999..8961)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013060081.1"
                     /locus_tag="LIT34_RS27800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27830"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_053488454.1"
                     /transl_table=11
                     /translation="MNGFRSDLIDHINQHLSSYKQSGRAEVDLLALKHLSKRGKLLNQE
                     LSGFSWGELYLTLSYFLKRRKMTEEDFEKAFGIECIFLSADIVDDICDLDDPNLPTFQN
                     EDRYLILISQYLLAKGFFYLRPVSDSYEDNCLFSLIMDSGCGEWKDLHFRFSINKRVIP
                     TEEEYFKLIKQKSGKLTEIISQAIDPSQLILKKITYYIGIAGQLRNDAADVLNDKKSDL
                     RDLKAYLPFLKAYEYSCEVQDEFFHKLKDEEIMTSPLKRQLIREYIEQSGSIDYCHILS
                     RFYYMRAFKLLEEHFKLSKKEMNYFKSLFLQRSQQHEQA"
     gene            complement(8948..9121)
                     /locus_tag="LIT34_RS27805"
                     /old_locus_tag="LIT34_27835"
     CDS             complement(8948..9121)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001030236.1"
                     /locus_tag="LIT34_RS27805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27835"
                     /product="hypothetical protein"
                     /protein_id="WP_013060080.1"
                     /transl_table=11
                     /translation="MTKTLWNFLMEMKKNNLTFENYELCPSLNALSPEEKVVLNEYARS
                     LVLENEVGNEWV"
     gene            9345..9485
                     /locus_tag="LIT34_RS27810"
                     /old_locus_tag="LIT34_27840"
     CDS             9345..9485
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_b"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000606628.1"
                     /locus_tag="LIT34_RS27810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27840"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_013060079.1"
                     /sec_met_domain="TIGR03731 (E-value: 1.6e-19, bitscore:
                     63.1, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_b (E-value: 4.7e-10, bitscore:
                     32.8, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNVKNLFDLDVQVTTASSDVDPQITSVSLCTPGCGDTGSWNSFC
                     C"
     CDS_motif       9345..9416
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNNVKNLFDLDVQVTTASSDVDPQ"
                     /locus_tag="LIT34_RS27810_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9417..9485
                     /prepeptide="core"
                     /locus_tag="LIT34_RS27810_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="13.90"
                     /molecular_weight="2066.4"
                     /monoisotopic_mass="2064.9"
                     /core_sequence="ITSVSLCTPGCGDTGSWNSFCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNNVKNLFDLDVQVTTASSDVDPQ"
                     /leader_location="[9344:9416](+)"
                     /alternative_weights="2084.4"
                     /alternative_weights="2102.4"
                     /alternative_weights="2120.4"
     gene            9560..9700
                     /locus_tag="LIT34_RS27815"
                     /old_locus_tag="LIT34_27845"
     CDS             9560..9700
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_b"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000606628.1"
                     /locus_tag="LIT34_RS27815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27845"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_013060079.1"
                     /sec_met_domain="TIGR03731 (E-value: 1.6e-19, bitscore:
                     63.1, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_b (E-value: 4.7e-10, bitscore:
                     32.8, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNVKNLFDLDVQVTTASSDVDPQITSVSLCTPGCGDTGSWNSFC
                     C"
     CDS_motif       9560..9631
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNNVKNLFDLDVQVTTASSDVDPQ"
                     /locus_tag="LIT34_RS27815_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9632..9700
                     /prepeptide="core"
                     /locus_tag="LIT34_RS27815_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="13.90"
                     /molecular_weight="2066.4"
                     /monoisotopic_mass="2064.9"
                     /core_sequence="ITSVSLCTPGCGDTGSWNSFCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNNVKNLFDLDVQVTTASSDVDPQ"
                     /leader_location="[9559:9631](+)"
                     /alternative_weights="2084.4"
                     /alternative_weights="2102.4"
                     /alternative_weights="2120.4"
     gene            9775..9915
                     /locus_tag="LIT34_RS27820"
                     /old_locus_tag="LIT34_27850"
     CDS             9775..9915
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_b"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000606628.1"
                     /locus_tag="LIT34_RS27820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27850"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_013060079.1"
                     /sec_met_domain="TIGR03731 (E-value: 1.6e-19, bitscore:
                     63.1, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_b (E-value: 4.7e-10, bitscore:
                     32.8, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNVKNLFDLDVQVTTASSDVDPQITSVSLCTPGCGDTGSWNSFC
                     C"
     CDS_motif       9775..9846
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNNVKNLFDLDVQVTTASSDVDPQ"
                     /locus_tag="LIT34_RS27820_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9847..9915
                     /prepeptide="core"
                     /locus_tag="LIT34_RS27820_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="13.90"
                     /molecular_weight="2066.4"
                     /monoisotopic_mass="2064.9"
                     /core_sequence="ITSVSLCTPGCGDTGSWNSFCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNNVKNLFDLDVQVTTASSDVDPQ"
                     /leader_location="[9774:9846](+)"
                     /alternative_weights="2084.4"
                     /alternative_weights="2102.4"
                     /alternative_weights="2120.4"
     gene            10001..13219
                     /locus_tag="LIT34_RS27825"
                     /old_locus_tag="LIT34_27855"
     CDS             10001..13219
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013060078.1"
                     /locus_tag="LIT34_RS27825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27855"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_146274444.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 7.1e-173,
                     bitscore: 569.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.2e-17,
                     bitscore: 56.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 7.5e-43, bitscore:
                     140.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILQKEKSNHKSSVTTENNLFEPLPFFMLRAPFLPTHTFDQLKDE
                     AVLVEKLRAYAEKDYVKEAIAIASPSLLNSLHYIHGDLNNRKTQQVLSSMLRYMLRMTT
                     RPTPFGAFSGVAAGQFKKNSSLKIDHFKEFKKRARPDMEWLLGVISVLERSNILPSLIV
                     DKNRASYVVGDRLHLPFSTECGQLRKKGMEKRENISIIYSEVVEKVLNLAEERITVREI
                     TQRLHTIYPNTDVTIIQRFIIQLLEQEYLITELRPPLTIDNPFNYLIRKLEEKDEKIEL
                     YEELLKVRELINTYNQLPLGEGLSLYSDLISQMRHIYEVTTPLQVDFSLNATDLTIGEK
                     VGEDISKAAQILWSIADEGVGFPHLQKYHVDFLEKYGTSREVPLLELLSEELGLGAPAS
                     YQNPHGKRGGDTTTSSINQERNSQLSYLLIKAIHNQEKEIEITEEIAQRMSKEKDRRYA
                     PDSLEVYGELHAASQEDLDQGNYTFCLSPNPGSNALGSTFGRFLDILDPDVSLKIQQYQ
                     QKIDLEFNEDTVMVEGSFLPATGRSANVAIGKTTRKVNVTLGTNGDEETIQLPIDDIVV
                     GASLENFYMKSKKLGKRIKVVAGNMLNYQSAPNIYRFMREISLNDLDQWRPFNWGSMAH
                     SPYYPRIRYKNIVLSPGIWKLNKEVFGMREKPQNEEEFFKAFGEWREKWSVPRNVFMTY
                     GDNRILIDLENTLHLRELKNELFKQGRLQLRETLQDRDQNCLNSPLGRHAVEIVVPLKK
                     TENTERRKKIGAIGEAKKDIVSNKIIYKLPGSEWLYVKLYAPNARENDLILKYLTPFAS
                     EMVKSDMASSWFFMRYRDPDAHIRLRFQGDPSKLSGLVLPRLREWADKLMDLGLLQKIT
                     IDTYEREVERYGGPMLIEKAEDYFHYDSQSVAMILSTLNQQNHLPAYVMASLSIIDIMD
                     NFGLNYAQQVASIENNTEKYEYIDEFRPLRKELSLIGDSRNDWENLRNYNSGVGKSIYE
                     SFLIRKESLTRYVTEIKELQKRDMLWNEHQMIMGAIIHMYCNRLLGANRELEKKALAFT
                     RHILSSQKYWRNKNEEYARSYNGK"
     aSDomain        10493..10774
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_LIT34_RS27825_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="7.00E-18"
                     /identifier="RREFam001.1"
                     /label="LIT34_RS27825"
                     /locus_tag="LIT34_RS27825"
                     /protein_end="258"
                     /protein_start="164"
                     /score="56.1"
                     /tool="antismash"
                     /translation="KNRASYVVGDRLHLPFSTECGQLRKKGMEKRENISIIYSEVVEKV
                     LNLAEERITVREITQRLHTIYPNTDVTIIQRFIIQLLEQEYLITELRPP"
     gene            13185..15068
                     /locus_tag="LIT34_RS27830"
                     /old_locus_tag="LIT34_27860"
     CDS             13185..15068
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129903.1"
                     /locus_tag="LIT34_RS27830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27860"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_013060077.1"
                     /transl_table=11
                     /translation="MKNTLDPTMENEKVSFVSILKSFRYWPSLFKLLWETHRGYFFCVL
                     VLNFLNGLLPASLILAIKYLVNMVQNLYIQGYKDNYFYDILPFFIFFSVVTLLTSATGS
                     ILETHKQLYRNLLSNKINVKLIEKAKRLPYASFENPEVYNKLQRARQDSTYKPFAIFEE
                     LMGIVKGAITLISISIILMVWNWEFTLILILLPLISAWSIVNVGKEIFLVSHKRAEETR
                     KQFYYYYLMTTDITVKEVKIFGLGSLLLRNYSDLFSKFYNQDRHLLLKKMRIDLSFQLI
                     SVIFVIFVQFMIVKDTIQGLIAIGSLIAYFQAVNTTQKTSNELMYMVFNMHQNNLYMTQ
                     LFSFLNVPESTDKPNVSEEKTLENVSSTEEGIQFLNVSFKYPGQENYTLKNVNFHIKPG
                     ETLALVGSNGSGKSTIVKLLTRLYTDYEGIILLNGKRIEDYQPQDWQDRISAIFQDFVR
                     YELDVKENIGYGDYKRSNHLVAIQAAAKRSGALTMIDSLPDKMDTQLGKTFANGIQLSG
                     GQWQRIAIARAYMRRASLYILDEPTAALDPAAEEEVFQDFQEIAQKSMGLFISHRYSTV
                     KYADRIIVLDKGEVAEYGTHVELLDTNGIYARLFNLQAKSYIEASATQASS"
     gene            15093..16451
                     /locus_tag="LIT34_RS27835"
                     /old_locus_tag="LIT34_27865"
     CDS             15093..16451
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001177658.1"
                     /locus_tag="LIT34_RS27835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27865"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_053488562.1"
                     /sec_met_domain="LANC_like (E-value: 3.4e-71, bitscore:
                     233.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSTTDQKTYWLKGIDNETRNKALKLVLSIAEKLKDPSGIEKIVM
                     APDNVSLAGNLNPWDPITLSHGFPGTILLFGELDRQFPDSGFDLVAHNHLVEVQKVIER
                     QGVNSISMFGGITGVAYATLYISHNYERYSRFLQVLNNFILMQLEKILNEPEKELGVHP
                     LKYDVIQGMTGIGRYLIENTKHKENHEALKKILAYFVDMASDIEVNGEKVPGWYVSKAN
                     QLLEKDRIMFPEGNFNCGLAHGIPGPLSFMALSIQKGIEIPGQREAVLKITNWLMKWKQ
                     VDSGWPSRLSFQEVATSKISHSYPKRQGWCYGDPGVARSIYLAGKALGDTAAIRSAVGA
                     YQDIIVEPKEEWELVSPTFCHGRAGLLQMLIRMAKDEENQISVQSIVELVHYIEESYDP
                     NAPFGFRDIESNGEKSHQLNKAGLLEGVTGVLLPLLSLSSVEEPWWDGAFLLS"
     gene            16476..17081
                     /locus_tag="LIT34_RS27840"
                     /old_locus_tag="LIT34_27870"
     CDS             16476..17081
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007729076.1"
                     /locus_tag="LIT34_RS27840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27870"
                     /product="flavoprotein"
                     /protein_id="WP_013060075.1"
                     /sec_met_domain="Flavoprotein (E-value: 3e-34, bitscore:
                     111.1, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVKNIVEKKILVGVSGSIAVAGIFQYLAMLKANFSEVKVVMTKG
                     AVQLIPAETVKLYCDEVFIDEKLSISGTIGHVELARWADLMAVLPATGNTLSKAAHGLA
                     TDLLSTVILAHDKPVIFFPNMNKLMWEKKVVQHNVKLLQQYDHIVVPPVKTTAFEIATM
                     SLRPNYVLPNPQNILNIISKQLEERNRLANICEKVEVQ"
     gene            17168..17902
                     /locus_tag="LIT34_RS27845"
                     /old_locus_tag="LIT34_27875"
     CDS             17168..17902
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001058380.1"
                     /locus_tag="LIT34_RS27845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27875"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_013060074.1"
                     /transl_table=11
                     /translation="MKKEIVLEANNITKTVSGKNIVSQFSTKVYKGDICGFLGPNGAGK
                     TTVMRMFTGLIRPTQGTIMVGGKDVNKDRQQALRNVGAIIESPIFFPYMSGRKMLQNLA
                     RLYPDLSRKEQLEQVEAALSVVRLTEDADVKIKNYSLGMRQRLGIAQALLGEPDVILLD
                     EPANGLDPMGMRELRELILELREKKNLTFFISSHLLDEIQQMCDHLVIIRNGKLVTQGS
                     KEELIKDPSKRLEDVFVEMMTS"
     gene            17899..18729
                     /locus_tag="LIT34_RS27850"
                     /old_locus_tag="LIT34_27880"
     CDS             17899..18729
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161130.1"
                     /locus_tag="LIT34_RS27850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27880"
                     /product="ABC transporter permease"
                     /protein_id="WP_053488561.1"
                     /transl_table=11
                     /translation="MKGLFTSELERLWSQKISWIILFFIPLMSLGSVKYYLNWNERVSP
                     GQPDYVTSLNFPIISISEHLVVSFNIIAIILISTVIANEIENGQLRMILIRPFSTTQLF
                     LAKLATILTTMFLYLTLFWILNTVAGYIFFPKVNTLITFLDEQKLSLASALLYNVKYFF
                     ACFVTMISVVSVFTLLGSISRSTMITLGAGVGFIFLAIAIPQLLEFSTQTIIGHSTVVH
                     LMYMSIVKIQHTGIAFLLSSTNNLNSYIILVQAVYIALFGLIGYWTFVKRDYFI"
     gene            18747..19508
                     /locus_tag="LIT34_RS27855"
                     /old_locus_tag="LIT34_27885"
     CDS             18747..19508
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000646187.1"
                     /locus_tag="LIT34_RS27855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27885"
                     /product="ABC transporter permease"
                     /protein_id="WP_013060072.1"
                     /transl_table=11
                     /translation="MKALFISEWERLWSQRKSKWMIGIFTVIVLLQAWFLRYYGVGIYN
                     NDQQVPLNTWNFPWFLLKESSFLLTLIFMPVFFLNSLNVEYNSGAYRLFLIRPFKRKSF
                     LISKWFSLALMVLVHLLIILGISIAFGFIFLKPDNDFTFYGQQKNAIEAILYTVQVYGL
                     FFIIQMCCLALASLISVIISNAVISFFLLIGLYVGCLYVSSQLSFFLLSVQSIFHTLST
                     TSNSLYVFAFVIMLVGFGACVRIWSKKEFTS"
     gene            19533..20312
                     /locus_tag="LIT34_RS27860"
                     /old_locus_tag="LIT34_27890"
     CDS             19533..20312
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013060071.1"
                     /locus_tag="LIT34_RS27860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27890"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_029321001.1"
                     /transl_table=11
                     /translation="MAILEAREITKVYKTKYRTYPVLKNISLDIEEGDFVAIMGPSGSG
                     KSTLLNVLSSLDIPSEGDIKVGGTTLTGMKEEQLGIYRREHIGFIFQNYNLLDHLTIEE
                     NILLPAALKKGDKKGVQNKLQKFAEELEVTKFLTKYPYEVSGGQQQRAAIIRALINNPA
                     LLFADEPTGNLDSKSAQNVLHTLKMLNEKYKTTILMVTHDSVAASFCNRVIFLKDGQIV
                     HEMKRSKLEDTSKFNQRILSFIAKEVEDNDINVEIYN"
     gene            20284..22125
                     /locus_tag="LIT34_RS27865"
                     /old_locus_tag="LIT34_27895"
     CDS             20284..22125
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1243: ABC
                     transporter, permease component"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013060070.1"
                     /locus_tag="LIT34_RS27865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27895"
                     /product="ABC transporter permease"
                     /protein_id="WP_252282061.1"
                     /transl_table=11
                     /translation="MISMWKYITKNITRNLSHYTVYILSSILSVAIFYMYAAFLLYPKV
                     SGTEQLLIACEIIILLFSCFFIAYSHEHFLRERKKEMGIWKTFGASRKQLFNVLVLENA
                     VVGTFSILVGILFGMLLSKIFFNFMSDILFSNQSFVYTFSPVAVFVTVILFGIVFLLVS
                     CRSYFKIKRIAVLELFQEEKKPKPSAQFSRVKFILSICFLLVSYIFISYASLPMLLFAF
                     LPLLALLLVGTYLFCSNGLVGVISYLNNKEKRQLNGIKMLTLISLRKRLYYNAKIIFIV
                     SILLSAIMISIGAIQLYIEKNSQRMQSTHPQGALFVASKGKENKIEDIIAELKRQGIKD
                     LHMNKWKGLKISSESGKKQFLVIQNDPSFIKDEDSLKNNNYIFNNKKTDDITNEILKLK
                     SEKGERDLNVKNMNGKKVLNPIDGIEGIISVPKNTFSEIYKTTISEKRLSLYKLDFKED
                     AKIYNILKKLSDTTLFKSDNLHSIRLLDYENTVQLSSILRLTGLFICLVLFLALASLLW
                     FKLYEDMNDDKKVFHSLRKVGLTAKEIKRTLYIQISVIFFVPLSLGGLNLFIATNALQN
                     ILEGITIYSIIVIFLIFGVSQFIIYLISSYFYSKKVL"
     gene            22209..22889
                     /locus_tag="LIT34_RS27870"
                     /old_locus_tag="LIT34_27900"
     CDS             22209..22889
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011986467.1"
                     /locus_tag="LIT34_RS27870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27900"
                     /product="response regulator transcription factor"
                     /protein_id="WP_013060069.1"
                     /transl_table=11
                     /translation="MQESILVVDDELEIVDIISDIFEDRGYRVLKAYNGEQALDQLKTN
                     VDLIILDVMMPQMDGFDLCKVIREQIYCPILFLSAKHSEMDKVKGFTLGGDDYITKPFQ
                     VKELIARVEAHLRREQRDRVSTQNQRLLGNLTINYSQHDVLLDGKKIDLTSKEFKILEL
                     LTVNLGQIFSKEQIYEKIWGIDAMGDLNTIIVHINNLRAKLTSGMSTYHIKTVWGVGYK
                     LEKR"
     gene            22889..24316
                     /locus_tag="LIT34_RS27875"
                     /old_locus_tag="LIT34_27905"
     CDS             22889..24316
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013060068.1"
                     /locus_tag="LIT34_RS27875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27905"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_182527911.1"
                     /transl_table=11
                     /translation="MIKRLSLKNQFILTFASVIFLSLISTICSLVLLYYFLSVYNEKSV
                     QPANYYEKKVPSIEKFVELKGEKILEVSFQKNLEKVIPMEGITYQVINLRGNKIYGTLD
                     DQLIENNKSIYEKVNRSDQKGKVITKYLPILDKNRMEGVLAVRYVLASSIDYYIKYIFL
                     IILLIPFLFLTLYSYVFARRFGKELNKPIKELSAASQKIKNQDLDFEIKYESENEIGVL
                     IDSFNSMKEELKTSLYLQWKLEQERRDMVASIAHDLRTPLTIILSHVEVLMDPSLNGQK
                     RLPQYLQTIKNNTQRVLHLTEEMKRVSEVDNPDFTLDIEGVIPIEMLPEMLEEFKKWAE
                     DEEIKFTYSLNRKPGEGNSEFALDPKRLHQILTNLISNSIRFTPVNGSIDVQVQIEKDM
                     MSFSISDTGKGFNTKDLPFLFSKFYQGDPSRNDQLHHGLGLYIVKELVIKHGGEIHARN
                     NEPQGACIEFTISSINK"
     gene            complement(24352..25767)
                     /locus_tag="LIT34_RS27880"
                     /old_locus_tag="LIT34_27910"
     CDS             complement(24352..25767)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016127292.1"
                     /locus_tag="LIT34_RS27880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LIT34_27910"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_078082290.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 6.5e-47, bitscore:
                     153.6, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKTSMTIITTLLICFCFTNYGHAKTETNQYYTVILKDRSKWTQS
                     IKKIKKSQGEITYTVPEIGLIQFKGNQKVAKTNASLFKSLSPSLKLEKPSTSKSFKKPN
                     SSVNSIKGLDSTLPALWDMQWDMKEITHNGESYNIESGSSNVTVGIVDSGIDIDHPDLV
                     DNLKSGSKNLVPKGGLRGTEPEETGDINSINDINGHGTMVAGSIAANGEIKGVAPNTGI
                     KVYRVFGNKSADAVWIIKAIIQAAKDDVDVINLSLGSYYIDGNIYKDGELLDNKWADVE
                     GYKLAIEYANKLGSVVVASAGNDSIDVSNKSELNDFLKKKYAEEGKTFNGVGIEAPGEL
                     PGVVTVSSTGPTQQLSLFSNFGKNYIDIAAPGGDSRLLEKYGQEAWWDGGLFRQEQVLT
                     TFNTGRYLFASGTSMAAPKVSATLALIIDQRHYKNRPSNSIDYLYKNGVKKDIEPNLAY
                     WGNGQLDVYNAVK"
     tRNA            complement(25795..25866)
                     /anticodon=(pos:complement(143197..143199),aa:Cys,seq:gca)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="LIT34_RS27885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="LIT34_27915"
                     /product="tRNA-Cys"
     gene            complement(25795..25866)
                     /locus_tag="LIT34_RS27885"
                     /old_locus_tag="LIT34_27915"
     misc_feature    complement(26423..26439)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 24.03"
                     /tool="antismash"
ORIGIN
        1 gggaagatta aggtccatta ctaatgatat acaacattat atagataccg cgtgattcaa
       61 aaagccgagg cttacctttt cggctttttt attatgatat gttatggaac tagaaggaga
      121 atttttactg ataccttgtt ttatgcgtac ctgattaggc aagtataata gacgacttat
      181 tccttcttcc cagaaagata aagtcgtcta caccattttt tcattcacta tgatttaccc
      241 tctcatttca catttttatt tataaattta ttggtttata tgtttctgtt ctaattcgtt
      301 tactacacct tcctggcatt cattgatgaa taaataagta aggtatgaat gtaagtcaaa
      361 ttgattttca ttaacaaacg tagaaaaaat gtttttatgt tcgctcacta gttttacctc
      421 ctatatgtaa gtttctattt tttattgtcc cccaactagt aatctcttat acatctaaat
      481 taacaacata ttttatagga acagctattt tcatttttca ttaaccttat gtcataatat
      541 tcacatttgc tacctgagct aatttcatta tgagtattat caagggcaaa aaaagaaccc
      601 tttgctataa aatagcaaag ggttttcaac tataacggaa tagggggaat acgttactag
      661 tctaaccgta tttatagatt aatatacatg gcggtttata ttttattgtt tataaaaagc
      721 taatcatatg aaatgaatat cgtctacaac tttagttaac ataaaaaaat tttcggaata
      781 cctttagata gggtagtttt tttgataatt aagatgtata ttatatacat cttaatttac
      841 catggtcact gctctagaaa catattgtcc caagtgaaaa aattcattaa tttaaaggag
      901 ttagaacatg gatatgagta atatagctaa atggattcct gttccttatt ttcaaattag
      961 gcaagatggt acaattctaa attcttcaaa tataactcat tcatattttc aatctacctc
     1021 tagcatatgg aatattattt ataaagaaga ccgaaataaa gcaatattaa tgctgtcaca
     1081 gattacaaat tcttaccctg taacccaata tcttattttg caaacaagca acaagttatt
     1141 tatgaatttc aaatgtacga tccaatggca ggacagtata ggtcatctag tatgcacaga
     1201 agccaaaaat atcaaagttc cctctgtttt atctgttcaa aaatctttag taaatactca
     1261 aaaacgttta gaagaatcag aaaagcattt aaacaacgtt attaagatat tggatataag
     1321 aaaacactaa gtttttcttt tttacatgaa tctttctgtt ctgagcaaac tacacgagac
     1381 gctgtgaggc atcagcgaaa atccttacag caatagagca gaaaaaacct acctctttgg
     1441 attggaaaga gataggtttt tttgtatttt taaggtgtgt aagatataca tctttagtta
     1501 acataaaacg gattataggt atctacaaaa ataaaaaaga aaattattgt aatccacctt
     1561 gtatataatt agggatctat attgagctca ttaactgaaa aaagtattcg gacttctgag
     1621 ttttatttaa cctataccat gaatctaatg tatttgatgc gaatacatct aattttttta
     1681 atacgtccct cgcgaattct agaggtgcta ctcctgaagc agtaatcatg ttattatcgg
     1741 atactacagg tccaacctca tacaacttct cccctttata gttgggacag accatttttg
     1801 tatattctaa gttattaagc gtatgctttc tagaatctaa gtatccacta tttgcaaggg
     1861 catcagtagc accacaaatt gcagctacaa tagtaccaag ctctaaaact tccccaactt
     1921 ttttcaatat aggttgatga atctcctcac tccatgtatt tcctcccggt agaattaaaa
     1981 gatctttatc caaaagagtg cactcatcaa gagaaatatc cggctgtata ctcagccccc
     2041 ccattgtttt aataatttct ttattaactc ctactgtcat tacttttaaa ggggctaaac
     2101 cttgtctgaa atatcttcct gaatttagtt cagcaattaa atatccatac tcccaatctg
     2161 acattgtgtt aaatacataa atataaactt ttttaatttg catactaagc ctccagaact
     2221 gacgttctct atattatacc atttcaaaga catatattta taaaaatgtt aaaatattca
     2281 gaaaaaaata aggagattga gaattatttg aaagaaaaca aaatagaaaa agtctggttc
     2341 tggtgcaaat acttcaattt acttataagc aatctctaaa acttggatat actgatacta
     2401 ttattcttaa aaaggtgtgt gatcggtatg gaaaaggaaa atgtattcaa atggaaacat
     2461 tatcagcctg atcttatttt gttaaatgta agatgttacc tacggtacaa tttaagtttt
     2521 cgtgacttga tagaaatgat ggaggaacgt ggattatgta ttgctcatac aacgattatg
     2581 cgttgggttc atcaatatgg tcctgaatta aatgagcgag tacgacgcca tcttaagcca
     2641 acgaacgatt cttggcgggt tgatgagacc tatgtaaaag taaaaggaca atggatgtat
     2701 ctctatcgtg ccgttgattc ggagggaaat acgattgatt tttatctaag taaagcaaga
     2761 aataaacaag cagccaagcg cttttttaag aaagccttgg ctttttcgca cgtttcgata
     2821 cctcgtacga ttacagtaga taaaaatcct gcttatccca ttgctatcca ggagctaaaa
     2881 aaggaaaaaa agatgcctga aggcatccaa ataagacaaa ttaaatatct aaataatatt
     2941 gtagagcagg atcacaggtt tattaagaag cgcctttcta cgatgttagg cttaaaaacg
     3001 tttcgtacag caaaagccat tatttctgga atagaggtca tgcatatgat gaaaaagaaa
     3061 caggtttatc aagaggtgaa gtctgtccaa aatcaaataa gtttcattca tcaactattc
     3121 gtaatagctg cataagaaca aatcctatag gaatttataa acctctttta tatagcttca
     3181 acctttgcac cagaaccggg ttttgtgcat attcaacaat cgggccatta tattgaataa
     3241 cttattatgg aaattataaa aaattgagat gattattatt aagttaaagg gaagtttagc
     3301 gtggccaccg accaactaag tggttgctta cactcaatta ttggaaggaa agttttatcc
     3361 tttcgcgaat tcattataca tgctgaaatt acgaaattcg caaaaaaatc gcggtagagc
     3421 attggaaaga gcattttaat tttctataac ttcatagaga ggtgattacg catgaatcaa
     3481 agaccgtcag aagaagaata tgcctgggcc atcggagagt atatccggtt ggtgccggat
     3541 ggcaacatca tcgacattct gctctcccag gaaaagcaaa tgacagaact gctggcatcg
     3601 ttgaccgaaa gccatggcgc gtatcggtat gcggaaggaa aatggacact gaaagaagtc
     3661 gtgggccaca tcgcagacgg agaacgcgtc atgacctacc gcctgctccg gttcgcaaga
     3721 ggggaccaga cgcctctgtc cggtttcgac caggaattgt tcatgcctcc tttcggatgc
     3781 tggtcaaccg cgcagttggc tgaagactac cgggctgtac ggcaatcgac gatcacactg
     3841 ctgcgcgggt taccggcgga ggcgtggtcc cgcaaaggca cagccaacaa cgcaagcatt
     3901 acggcgcgtg ccctcgcgta cggcattgca ggacacgaga ttcatcacat gggggttatc
     3961 cgaactcggt atttgagtta gttatccgga agatcgggac ggaagctgcg cggaaaacgc
     4021 ggctttcgtt ctttctttat ggcagccttc ccgccccgtt catagacaga tatgaagaga
     4081 ggacaagacg ggttgaaaaa agcagcagcg attggttgca gacaggattt tgtctaaaaa
     4141 cgaaaagcaa ataataatct caaacaagaa aaaatcaagg cctcttcgtt aagctaacga
     4201 agaacgagag ctcaatacat tatactaatc ttttcatgtg aaggtagccg ggtattaaag
     4261 ttaaatgtgc aaaataacac ttaaaataag tgcaatttat aggtcaaagt gacatgatgg
     4321 gcatgtgacg gtacccatcc atgacaaaac gtataataag gtatattatt ttttatgggt
     4381 ttaaaaaggt ttagttttga gagttaatag acgcgttgtc attaggtttt taactgtcta
     4441 aataggtgta cctttttagt ctcacaagag ttatagaaaa acttcgtatt tgtcgttaca
     4501 aagagtaaat attaaaactt tattttttat aaagaagttt atatatttac ttttttgtat
     4561 agaatacatt tcttttatat tttcagttaa atatatattt ttaaaaagat aataacattg
     4621 aatgtttata aatcttatat ttggttgtct ttaataaaac aatttcttaa aaggtaagta
     4681 gaggataggt ctgtatacca taagaagtaa aagacaccgt ttgtcattat taaataaaac
     4741 aaacagtgta ggacttataa gtgcatgttc tacacatttt aataagttat ttccttctat
     4801 attttcccat gtatgaaata gggtcaggat ggatccttcc tgctattgtg ggtggacttg
     4861 caagagttgg tattagtaaa gttaattatg gagaaaaact ttttagtgta acaagagtta
     4921 aaaaataact aaatctaaat tttcaagaag tatgtagaca agagatggca tcaataaata
     4981 aattattatt aattggaaca aactcctcaa gatgacttga ggagtttgtt ctttaaataa
     5041 gatatgtgta acagaaaagc tccccctaac gcaccaggga ttttttctat ttttctaatg
     5101 aattatttat cttcttcttt tagttaggca aggcaattgt catctactat atcttcatta
     5161 agctcacctt taactgtatt ccatctgata aatctttcat cgtgcacact tacgatatag
     5221 aaatatctag ttttgaattt atttatatat ctttttctgc tattttatct atttctaaat
     5281 tttaaaaatc ttcaatcaac ccttttttaa tgccttttac tactgctcct actcgtgaat
     5341 ctacatctaa ctttctaata atagaagaaa tatgatattc tactgttctt ttactaattg
     5401 aaagatccat actaatttca taattcgtct tatctttgga aattaaaaga agtatctttt
     5461 gttccgcaga agtaagggtt tcaaagtcct tcgtgctaat ctggttttta gagaatagta
     5521 tatagcccat attactttga cggatagcat ttgctaaatc gaaagcagat ctttcttttg
     5581 taatatacgc actagctcct gctttaaatg ctgcattgta gtattcctcg tgatcatagc
     5641 ctgataaaat gacaactttt atttctggaa atttagacaa aagttctttt gttaactcaa
     5701 ttccgttaaa ttctttcata cgaacatctg taacgactac atcaggggat gtagttgcta
     5761 caacttctat taaagacgag ggatcattga ctgtatctat aatctcaatg tcttcttcgc
     5821 tttcgagtaa tcttctgatt cctaacatta cgagtaaatg atcatccact agtagcgtac
     5881 gtatactcat ttttatcctc ccagtccaat ggaatagtaa atgtaacaaa agtaccttgt
     5941 cctttatcag aagaaattct catactccca tttaattcag caatttgacg atgaatagtt
     6001 agtaaaccaa ggtggttacc tttactaaaa tcaaagaaat tgtctgggac atcaaatcct
     6061 atgccatcat cttttacgct gcactggtag aaaccattct cttctaaaat aagaacctta
     6121 atgtttttac cttttgaatg tttaacagca ttatttaaca gctcttttat tattcgataa
     6181 acttgtattt catgattttt agaaatgatt ttgaactcac aattaaattg aacatgaatt
     6241 aagatactat aatttagttc aaattctcgt tttaaagact gtaaacttgg ctctagaccc
     6301 aaatcctcca cgatgatagg gtggaggtca tgacacatct ttcgaatgtt ataaatcatt
     6361 ccttcaagct gatcatccat ttcgtctagt aatgttactg agaaattcct ttttgtttgc
     6421 attattctaa cttcattcaa ttgcaaaata agactttgaa ggatttcatc gtgtaagaaa
     6481 atggacaatc ttttcctctc tttttctaga gactgaatga cttggtgatt aaattggttc
     6541 cagttctgaa ctcttgtctt tgttcgacgt atttgtttgt cattaatatt gagaatagct
     6601 gcacttgaaa gtatatctgc tgattcacat attagttctt taagctcaat gaactctttc
     6661 ccttggaaga gagtatggtt gtttttttca cctataacaa taacaccttg aactaattgg
     6721 tttattgcga ttggaaaaca gattaagtga tatttttcaa aatgcatatg tatgctaggg
     6781 gtttgatctt caacaagaag tatatctttt tcaagtttgt ttatttcatt aagaaagtta
     6841 aattgattca tggtttgaaa aatgcccgtc tcatgtaatg aatgatatat attattagaa
     6901 ttccacacaa tgcataaacc attgatatcg aacttctgat gaatgacttt tcctataatt
     6961 tttgcaagat ttttagcatg tttttcttta gacaatgttt ggaaaagttc aatttcattc
     7021 aggtccgtgt tctctctatt ttttgtcttc ttttgtataa aagtgttaat acctatttta
     7081 taaaggaaaa tagatgccca tgcagataaa aggccaacgc tacatatgac aaataattct
     7141 ctattagaaa ggtgcataaa ttgtttaatt aaaatactaa aaagcaaaaa gttaagtatg
     7201 taataaatca atatattaat ccacttagaa atttccaatt caacttcaat aatttcatgc
     7261 tttactaata agtaagaagt tgtcagtggg aagactataa tgctgggtaa acaatagaca
     7321 aaaggtattt gagattctcc aaaaatcatt ccaggtatta aattgaataa aaaaagtgga
     7381 ccaaagctaa aaacaattcc aaagatcaag atatataact gatttcttac ttttaatgaa
     7441 ttagttttta gatgtaaaga gataagaaaa atacagccca caatactaaa gaacaagtta
     7501 ccgattaata aaactctgta tatgtaaaaa aatttagaat gctctacata accaaggtaa
     7561 ttgcaaatta agtacactac agatgacagg gttgagaaaa gtaatgatga aaaaattata
     7621 attttcacat aattaggttt agtcgaaact gggaagtggg cgaagaaact tagtaataag
     7681 taagagagca taaatacact aatgatctct atagttttaa aaactggtat atcctgactg
     7741 gacaaaacag aagtagaaat agcaatacca gagacagatg ttaataagaa gaaatttttt
     7801 atcacgatgg atttttgttt cttaaaaaag ctaaataatc cgatgctaaa aaatatcaca
     7861 ctaataacac ttgttacata aaaagaattt aaagttgccg aatccacaaa tcttctaaaa
     7921 tcgcttagat ataaataata accattcgcc ataaaaatga tgatgtacaa agtgcctaaa
     7981 ggcaaacaaa ttaataaatt atgcttgttc atgctgttga ctcctttgta gaaataaaga
     8041 tttgaagtag ttcatttctt tctttgaaag cttaaaatgt tcctctaaaa gcttaaatgc
     8101 cctcatatag taaaacctgg ataagatatg acaataatcg atagagccag attgttctat
     8161 gtattctctt atcaactgtc tttttaaagg agaggtcatg atttcttcat cttttaactt
     8221 atgaaagaat tcatcttgta cttcacaact gtactcataa gcttttaaaa aaggcagata
     8281 cgcttttaaa tctcgaagat cacttttttt gtcatttagc acgtctgcag catcatttct
     8341 caattgtcca gctatgccta tataataagt gatttttttt aatataagtt gtgaaggatc
     8401 gatagcttga gaaattatct ctgttaattt accggatttt tgtttaatca gtttaaaata
     8461 ctcctcttca gtaggtataa ctcttttatt tatagagaaa cgaaagtgga ggtctttcca
     8521 ttctccacat cctgaatcca ttatgaggct aaagaggcaa ttgtcttcat aagagtctga
     8581 tacaggtctg agatagaaga agccttttgc cagtagatat tgagaaatga gtataagata
     8641 tcgatcttca ttttgaaagg ttggaagatt cggatcatca agatcacata tatcatctac
     8701 tatgtcggca gataagaata tacattcaat accaaaagct ttttcgaaat cttcttctgt
     8761 catttttctt ctttttaaaa aataagagag agtaaggtat agttctcccc atgagaatcc
     8821 tgaaagttct tggtttaata attttcctct tttagagagg tgctttagag caagaaggtc
     8881 tacttctgct cttccacttt gcttatagct agaaagatgc tggttaatat gatcaattaa
     8941 atcgcttcta aacccattca tttccaacct cgttttctaa aactaaactt cttgcatatt
     9001 catttaatac aactttttct tcaggtgaca gggcattcaa agatggacat aactcataat
     9061 tttcaaaggt aagattattt tttttcatct ccattaaaaa attccatagt gttttagtca
     9121 taagaaaaac cctctttcta gaaaatggtt attaaactac tataagtaaa aatgtacatt
     9181 agaactattt atttttcaat actatacttt tatgtatttt tttgcatatg cggaaattta
     9241 caaaatctta ttgcggtata tacggattct ttataaaaaa gcgtctggta aattaaatgt
     9301 ataagacata gcgtcttaat aaaaactttc tgggggaatg aaaaatgaat aatgtaaaaa
     9361 acctttttga tttagatgta caagtaacaa ctgcttcaag tgatgtagat ccacaaatta
     9421 caagtgtatc tttatgtaca ccaggttgtg gagatacagg tagttggaac agcttctgct
     9481 gttaattagt aatagagctt tataagaagg aaatggaaaa gatgtaattc ttaataaaaa
     9541 ctttctgggg gaatgaaaaa tgaataacgt aaaaaacctt tttgatttag atgtacaagt
     9601 aacaactgct tcaagtgatg tagatccaca aattacaagt gtatctttat gtacaccagg
     9661 ttgtggagat acaggtagct ggaacagctt ctgctgttaa ttagtaatag agctttataa
     9721 gaaggaaatg aaaaagatgt aattcttaat aaaaactttc tgggggaatg aaaaatgaat
     9781 aacgtaaaaa acctttttga tttagatgta caagtaacaa ctgcttcaag tgatgtagat
     9841 ccacaaatta caagtgtatc tttatgtaca ccaggttgtg gagatacagg tagttggaac
     9901 agcttctgct gctaattaga agttgaaaaa gagggaaaca atgttgttcc ctcttttctc
     9961 ttcttttgaa ttatattata aaaggaaagg gagattaaaa ttgatattac aaaaagaaaa
    10021 atccaatcat aaatctagcg taactactga aaataattta tttgaacctc ttccattttt
    10081 tatgttaaga gccccgtttt taccaaccca taccttcgac caacttaaag acgaagcagt
    10141 attagtggaa aagttaagag cttatgcaga aaaagattat gtaaaagaag ccattgctat
    10201 tgcaagtcct tctctattaa attcccttca ttacatacat ggtgatttaa ataatagaaa
    10261 aacccaacaa gttttatctt ctatgttgcg ttacatgtta agaatgacaa ctagaccaac
    10321 tccttttgga gctttttcag gagtagcagc tggacaattt aaaaagaatt cttccctgaa
    10381 aatagatcat ttcaaagagt ttaagaagag ggcacgacca gatatggagt ggcttttggg
    10441 agttatttca gttttagaaa gaagcaatat ccttccttct ctaattgtag ataagaatcg
    10501 tgcatcgtat gtagtaggcg atcgtcttca tttgccattt tcaactgaat gtggtcaact
    10561 tagaaaaaag ggaatggaga aaagagaaaa tatttccata atttatagcg aagtggttga
    10621 aaaggttctt aatttagctg aggaaagaat aacagtgaga gaaattacac aaaggttaca
    10681 tactatttat ccaaatacag atgtgacaat aatccaacgc tttattatac agctattgga
    10741 acaagaatat cttataacgg aactaaggcc tcctttaact attgataatc catttaatta
    10801 tctcattaga aaattagaag aaaaagatga gaagatagag ctctatgagg aactgttaaa
    10861 ggtaagggaa ctaatcaata cttataatca attaccatta ggagaaggtc tctcccttta
    10921 tagtgatttg atttcacaaa tgcgacatat ttatgaagtt acaactcccc ttcaagtaga
    10981 tttctcctta aatgccacag acttaactat tggagaaaag gtaggagaag acataagcaa
    11041 agctgcccaa atattatggt cgatagctga tgagggagtg ggatttccac atttacaaaa
    11101 gtatcatgtt gattttttag aaaaatacgg aacatctaga gaagttcctt tactagaatt
    11161 attaagtgaa gagttaggtc tcggtgcacc tgcctcttat caaaatccac atgggaaaag
    11221 gggaggagat actaccacct cttctataaa tcaagaacgt aatagtcagt tatcatatct
    11281 tcttattaaa gctattcata atcaagaaaa agaaatcgag attacagaag aaatagctca
    11341 gagaatgagt aaagaaaaag atagaagata tgcgcctgac tctttagaag tatatggaga
    11401 gttacatgct gcttcacaag aggacttaga tcaaggtaac tatacattct gtttaagtcc
    11461 taaccctgga tctaatgcct taggtagcac atttggtcga tttttagata tcttagatcc
    11521 ggatgtttcg ttaaaaatac aacagtatca acaaaaaatt gaccttgaat tcaacgaaga
    11581 taccgtgatg gtagaaggct cctttctgcc agcaactggc cgatcagcca acgtagcaat
    11641 tggaaaaacg acaagaaaag tgaacgtcac tctgggaaca aacggtgatg aagagacaat
    11701 ccagttacct atcgatgata ttgtggtagg agcatcgtta gagaacttct atatgaagtc
    11761 aaaaaaacta ggcaaacgaa ttaaagtagt agccggtaac atgcttaatt atcaaagtgc
    11821 gcctaatatt tatcgtttta tgagggagat ttcactcaat gatttagacc aatggcgacc
    11881 atttaattgg ggaagtatgg cacactctcc ttactatcca agaattcgct ataaaaacat
    11941 tgttctttcg cctggtattt ggaaattaaa taaagaggtt ttcggtatga gagagaagcc
    12001 tcagaatgag gaagaatttt ttaaagcttt tggagaatgg cgcgaaaagt ggtcagttcc
    12061 tcgtaatgta tttatgactt atggagacaa tcgcatctta attgacttgg agaacacttt
    12121 acacctacgt gaactaaaaa atgaattatt caagcaagga aggttgcaat taagagaaac
    12181 tcttcaagat cgggatcaaa attgcttaaa tagcccttta gggagacatg ctgtagaaat
    12241 agttgttcct ttaaagaaaa cagaaaatac tgagcgaaga aagaaaattg gtgcaatagg
    12301 ggaagcgaaa aaagatattg taagtaataa aataatctac aaattaccag ggagcgagtg
    12361 gttatatgta aaactctatg ctccaaacgc aagagagaat gacttaatac taaaatatct
    12421 tacgcctttc gctagtgaaa tggttaaaag tgatatggca tcatcatggt tctttatgcg
    12481 ttaccgagac cctgatgcac atattcgttt acgctttcag ggagaccctt ctaaacttag
    12541 tggtctagtt cttcctcgtt taagggaatg ggcagataaa ctaatggatt taggattact
    12601 ccaaaagatt actatcgaca catatgaacg agaagtagag cgttatggtg gtcccatgtt
    12661 aatagaaaaa gctgaggatt attttcatta cgatagtcag tctgtagcca tgattctcag
    12721 tacgttaaat caacaaaatc atcttccagc ttatgtaatg gcatcgctct caattataga
    12781 catcatggat aactttgggt tgaattacgc gcaacaagta gcctctatag aaaataatac
    12841 agaaaaatat gagtatatag atgaatttag accgttgcga aaagaattat ctctaatagg
    12901 agattcacga aatgattggg aaaacttgcg taattataat tctggagtcg gtaagtctat
    12961 atatgaaagt ttcttgattc gtaaagaatc tttaacccgt tatgtgactg aaattaaaga
    13021 gttacagaaa agagatatgc tttggaatga gcatcaaatg attatgggag caattattca
    13081 tatgtactgt aatcgattat taggagcaaa tagagaatta gagaagaaag cattagcttt
    13141 tactagacat attttgtcca gccagaagta ttggaggaat aagaatgaag aatacgctag
    13201 atcctacaat ggaaaatgag aaagtatcat ttgttagcat tctaaaatct tttcgatact
    13261 ggccgagtct atttaagctt ttgtgggaga cacacagagg atatttcttc tgtgttcttg
    13321 tcctaaattt tctaaatggg ctattaccag cttccttgat tttagcaata aaatatcttg
    13381 taaatatggt gcaaaatttg tatatccaag ggtacaaaga taactatttt tacgacattt
    13441 tacctttttt tatcttcttt tcagttgtca ctttattaac cagcgctacc ggttcaatcc
    13501 tagaaacgca taagcaacta tacagaaacc tactgtctaa caagataaat gtaaaattga
    13561 ttgaaaaagc gaaaagacta ccttatgcaa gctttgaaaa cccagaggta tacaataaac
    13621 tccaacgagc aaggcaagat tccacgtata agccgtttgc tatttttgaa gagttaatgg
    13681 ggatcgtaaa aggtgctatt actttaattt ctatttcaat aattttaatg gtttggaact
    13741 gggaatttac attgatctta attttattac ctttaatatc cgcctggtct attgtgaatg
    13801 tgggaaaaga aatattttta gtaagccata agcgagcaga ggagacaaga aaacagtttt
    13861 attactacta tctaatgacc actgatatta ccgttaaaga agttaaaata tttgggttag
    13921 gcagcttact actaagaaac tattcagact tatttagtaa gttctataat caggatcgcc
    13981 atttgctttt aaaaaagatg agaattgatt tatcttttca attgataagt gtaatttttg
    14041 taatattcgt tcaatttatg attgttaaag atacaatcca gggattaatt gctattggta
    14101 gccttattgc ttattttcaa gctgtcaaca cgactcaaaa aacgtcaaat gagttaatgt
    14161 atatggtttt taacatgcat caaaacaatc tatatatgac acaattattt tccttcctta
    14221 atgttccaga aagcacagat aaacctaatg tctcagagga aaaaacgtta gaaaatgtct
    14281 cttcaacgga agaaggtatt caatttttaa atgtatcctt taaatatcca gggcaagaga
    14341 attacacatt aaaaaatgtt aattttcata ttaaacctgg agagactttg gctttagtag
    14401 gatctaatgg atctggaaaa tcaacaattg ttaagctgct aacacgacta tatacagatt
    14461 atgaggggat tattctcttg aatggtaaaa gaatcgagga ctatcagccg caagattggc
    14521 aggatagaat tagtgctatt ttccaagatt ttgtgagata tgagttagat gtcaaagaaa
    14581 acattggtta tggtgattac aaaaggtcta atcatttagt agctatacaa gcagcagcta
    14641 agaggtccgg agcgcttaca atgattgata gcttgcctga taaaatggat actcagctcg
    14701 gaaaaacttt tgctaacggt attcaattat ctggaggcca atggcaaaga attgctattg
    14761 cgcgagccta tatgagaaga gcaagtttat atattcttga cgaaccgact gctgctttag
    14821 atccagcagc cgaagaagaa gtttttcaag attttcaaga gattgctcag aaaagtatgg
    14881 gacttttcat atctcatcgc tactcaaccg taaaatacgc tgacaggatt atagtacttg
    14941 ataaaggaga ggtcgcggag tatgggactc atgtagaact tttagacaca aatggaatat
    15001 acgccagatt atttaatctg caagctaaga gttatataga agctagtgca acacaagcaa
    15061 gctcataaga tgtaaggaga aaggagaaaa ttatgccatc tactactgac caaaaaacgt
    15121 attggttaaa gggaattgat aatgagacaa gaaataaagc actaaaatta gtgttaagca
    15181 tagctgaaaa gttaaaggat ccaagtggta tagaaaagat agtaatggct cctgataacg
    15241 tatcattggc aggtaatttg aatccatggg accctatcac attgtcccat ggttttccag
    15301 gcactatttt attatttgga gaacttgacc gtcagttccc tgatagtggg tttgaccttg
    15361 tcgcacataa ccatttagta gaagtacaga aggttattga aaggcaaggg gtcaatagta
    15421 tttcgatgtt tggaggtata acaggtgtcg cttatgccac gttatatata tcccataatt
    15481 atgagaggta ttctagattc ctccaagtct taaataattt tatattgatg caattagaaa
    15541 agatattaaa tgaaccagag aaggaactag gtgtacatcc tctaaaatat gatgtgatac
    15601 aaggaatgac aggaataggt cgctatctca ttgaaaatac gaagcataaa gaaaatcatg
    15661 aggcactaaa aaaaatactt gcttattttg tggatatggc ttctgatatc gaggtaaatg
    15721 gtgaaaaagt accggggtgg tatgtttcaa aagcgaatca actactagaa aaagatagaa
    15781 ttatgtttcc agaagggaat tttaattgtg gtcttgctca tggcataccg ggtccactgt
    15841 cttttatggc tttatcgatt caaaagggaa ttgaaatacc tggtcagagg gaagctgtac
    15901 tcaagattac caattggtta atgaagtgga aacaagtaga cagtggttgg ccttccagac
    15961 ttagttttca agaagtagcc acttctaaaa tatctcattc ttatccaaaa cgtcagggct
    16021 ggtgttatgg agacccaggc gtagcgagaa gtatatattt agcaggaaag gccttgggcg
    16081 acacagcagc aataaggagt gcagtgggag cttatcagga cataatagta gaaccaaaag
    16141 aagaatggga attagtatcg ccaacatttt gtcatggaag agcaggatta ttacaaatgc
    16201 ttataaggat ggcaaaagat gaagagaatc aaatctcagt tcaatcaata gtagagttag
    16261 tacattatat agaagaatca tatgacccta atgcaccctt tggttttaga gatatagaat
    16321 ccaatggaga gaagtcacat caattaaaca aggctggatt actcgaaggt gtaactggcg
    16381 tattattacc tttactaagt ttaagttcag tggaagaacc ttggtgggac ggggcatttt
    16441 tactttctta attaagattc agggggctat gataaatgga cgttaagaat attgtagaga
    16501 aaaaaatact agtaggggta agtgggtcga ttgcagtagc aggcattttt caatatttag
    16561 ctatgctaaa ggcaaacttt agtgaggtaa aagttgtaat gacgaaaggt gcagttcaac
    16621 ttatcccagc tgagacagta aagttatatt gtgacgaggt atttattgat gaaaagctta
    16681 gcataagtgg aaccatagga catgtggaat tagcgaggtg ggccgattta atggccgtac
    16741 ttccagctac aggaaacaca ttatctaaag cagctcatgg tctagcaact gatttattaa
    16801 gtacagtaat actagctcat gataaacctg ttatcttttt tccaaacatg aataaattaa
    16861 tgtgggaaaa gaaagtagtt cagcataatg ttaagctact acaacaatat gatcatattg
    16921 ttgtacctcc tgtaaaaaca acagcttttg aaattgcaac tatgtcattg agacctaact
    16981 atgttttacc taatccgcaa aatatattga acatcatttc taaacaatta gaagaaagaa
    17041 atagactagc gaatatttgt gaaaaagttg aagttcaata aaaactcaca aaaatgtgag
    17101 tttttttctt ttctttattt tttatttata tttgtctttt atattaaaac ataaggaggg
    17161 attgaatatg aaaaaagaaa ttgttttaga agcaaataat atcacaaaaa cagtgagtgg
    17221 aaagaatatt gtaagtcaat tctcaactaa ggtgtataaa ggagatatat gcgggttttt
    17281 gggaccaaat ggagctggaa aaacaactgt tatgcgaatg tttacagggc ttattcgccc
    17341 tactcaaggc acaataatgg tagggggtaa agatgtaaat aaagatagac aacaggcttt
    17401 aagaaatgta ggagcgatta tagagtcccc tatctttttc ccgtatatgt caggcagaaa
    17461 gatgttacaa aatttagcga ggctatatcc cgacctttcg agaaaagaac agttagagca
    17521 agtggaggca gcattatctg ttgtaagact aacggaagat gccgatgtaa aaattaagaa
    17581 ttattcatta ggtatgcgac aaaggctggg aattgctcaa gccctcttag gagaaccaga
    17641 tgtcatttta ttagatgagc cagcaaatgg tcttgaccct atgggaatga gagaattaag
    17701 agaattaatt cttgaacttc gagaaaagaa aaatctaaca tttttcattt ctagtcattt
    17761 acttgatgaa atccaacaaa tgtgtgatca tcttgtcatt attcgtaacg gtaaacttgt
    17821 tacacaagga agtaaagaag agttaattaa agatccaagc aagagactgg aagatgtatt
    17881 tgtggagatg atgacatcat gaaaggactt ttcacttcag agttagaacg attatggtcc
    17941 caaaagatat catggatcat actatttttt atacccttaa tgtcgctagg ttcagttaaa
    18001 tattacttaa attggaatga acgagtgtca ccaggacaac cagattatgt aacttctttg
    18061 aacttcccta taattagcat ttctgaacat ctcgttgttt cttttaatat catagctata
    18121 atactaattt ctacggttat agctaatgag atagaaaatg ggcagctaag aatgatcctc
    18181 atccgccctt tttctaccac tcaacttttt ttagcaaaat tagctactat tttaacaacc
    18241 atgttcttgt atttaactct attttggatt ttaaataccg ttgctggtta tatctttttt
    18301 cctaaggtta ataccttaat aacatttcta gatgagcaga aattatcttt agcatcagct
    18361 ttattatata acgtaaaata tttctttgct tgttttgtga caatgattag cgttgtatca
    18421 gtttttacat tattaggatc gataagcaga agtacaatga taacacttgg ggcaggggtt
    18481 ggctttattt tcttagcaat tgccattcct cagctcttag aattctcgac gcaaacaatt
    18541 atcgggcaca gcacagtggt tcaccttatg tacatgtcta tcgtgaaaat tcagcacaca
    18601 ggaatagcgt ttttactttc atcaactaac aatctaaatt cttacatcat tttagttcaa
    18661 gccgtataca ttgctctatt tggcttaatt ggttattgga catttgtgaa gagagattat
    18721 tttatttgac tcaaggaggg ttttaattga aagcattatt tataagcgaa tgggagagac
    18781 tttggagcca aagaaaaagt aaatggatga ttgggatttt tactgtaatt gtacttcttc
    18841 aagcttggtt cttaagatac tatggagttg gaatttacaa taacgatcag caagttcctt
    18901 taaatacttg gaattttcca tggttcttat taaaagaatc ttcattctta cttacattga
    18961 tctttatgcc agtatttttt ctgaatagcc ttaatgtaga atataactca ggagcatatc
    19021 gtcttttttt aattagacct tttaaaagaa aatcatttct aatttcaaaa tggttctctc
    19081 ttgccttaat ggtactagta catttattaa ttatcctagg gattagtata gcgtttggtt
    19141 ttatcttctt aaaaccagat aatgatttta ctttttatgg tcaacagaag aatgctatag
    19201 aagctatatt atatacagta caagtgtatg gtctcttttt catcatccag atgtgctgtt
    19261 tagctcttgc tagtttaatt agtgtaatta tttcaaatgc agttattagc ttcttcttgt
    19321 taattgggtt atatgtaggt tgtttgtatg tttccagcca actttcattt ttcttattat
    19381 cagttcaaag tatctttcat actctgagta ctactagcaa ttctttatat gtttttgcat
    19441 ttgttattat gttagttggt tttggtgctt gtgtaaggat ttggagtaaa aaagaattta
    19501 cttcttaaat aaagatagga ggaagaatta aaatggctat attggaagca cgagaaatta
    19561 caaaagttta taaaactaag tacagaacgt accctgtctt aaagaatata agtttagata
    19621 ttgaagaagg cgattttgta gcaattatgg gtccttcggg aagtggaaag tctaccttat
    19681 taaatgtgct ttcttccctt gatatcccct cagaagggga tatcaaggtc gggggaacta
    19741 ctctcacagg tatgaaagaa gaacaattag gtatttaccg acgtgagcat attggtttca
    19801 tctttcaaaa ttacaacttg ttagatcatt tgactattga agaaaatatt ttattacctg
    19861 ctgctttaaa aaaaggagat aagaaaggtg tacagaataa acttcaaaaa tttgctgaag
    19921 agttggaagt gacaaaattt ttaactaaat atccttatga agtctctggg gggcaacagc
    19981 aaagagctgc catcattcgt gctcttatta acaatcctgc tttattattt gctgatgagc
    20041 ctacagggaa tttagattct aaatctgctc aaaatgttct acatacttta aaaatgttaa
    20101 atgaaaagta caaaacaact attttaatgg taactcatga ttcggtagct gctagctttt
    20161 gtaacagagt catattttta aaggatggcc aaattgtcca tgaaatgaag cgttccaaat
    20221 tagaagatac gtctaagttc aatcaaagaa tcttatcttt tatcgctaag gaagtggagg
    20281 ataatgatat caatgtggaa atatataact aagaatataa cccgtaatct ttctcattat
    20341 acagtataca tacttagtag cattctttct gtagcaattt tttatatgta cgcagccttt
    20401 cttttatatc caaaggtttc gggaacagaa cagttattaa ttgcatgtga aattattatt
    20461 ttgctatttt cttgtttttt tatcgcatat tcacatgagc atttccttag agaaagaaaa
    20521 aaagaaatgg gtatttggaa aacatttggg gcctctagaa agcaattgtt taacgtgctc
    20581 gttttagaga acgccgtagt tggtacgttt tctattttag ttggcatttt atttggaatg
    20641 ctgttatcaa agattttctt taatttcatg agtgatattc tattttcaaa tcaatcgttc
    20701 gtttatactt tctctcccgt ggctgttttt gttacggtta ttttatttgg aatagtattt
    20761 ttacttgttt catgtcgtag ttatttcaag attaaacgaa ttgcagttct agagttattt
    20821 caagaagaaa aaaaacctaa accttcagct caattctcta gggttaaatt cattttatct
    20881 atctgctttc ttttggtttc ttatatattt atctcttatg catctttacc tatgctatta
    20941 tttgcttttt tacccctatt agcattatta ctagtaggca catacctatt ctgttcaaat
    21001 ggtttagtag gtgtaatatc ttatttgaat aataaagaaa aacggcagtt gaatgggata
    21061 aagatgttaa ctcttataag tttgagaaaa agattatatt ataatgcaaa gattatcttc
    21121 atcgtatcta ttctattatc tgcaattatg atatcaatcg gtgctattca gttatatata
    21181 gaaaagaaca gtcaaagaat gcaaagcact caccctcaag gagcattatt tgttgcatca
    21241 aaggggaagg aaaacaaaat agaagatatt atagctgaat tgaagagaca aggaataaag
    21301 gatttacaca tgaataagtg gaaaggatta aaaatttctt cagagagtgg gaagaagcaa
    21361 tttttagtaa tacagaatga cccatctttt ataaaagatg aagattcgtt aaaaaataat
    21421 aattatattt ttaataataa aaaaactgat gatattacta atgaaatctt aaaattaaaa
    21481 tctgaaaaag gggagagaga tctaaacgta aaaaatatga acggtaaaaa agttcttaat
    21541 cctatagatg gaattgaggg tattatctct gtaccgaaaa acacttttag tgaaatatat
    21601 aaaacaacga tttctgaaaa aagattgtca ctctataaat tagattttaa agaggatgca
    21661 aaaatttata acattttaaa gaaattatca gatacaacct tgttcaaatc ggataatctt
    21721 catagtattc gacttctcga ttatgaaaat acagttcaat tatcttcaat attgagactt
    21781 acaggactgt ttatatgctt agttttgttt cttgctttag ctagtctgct ttggtttaaa
    21841 ctgtatgaag atatgaacga tgataaaaaa gtattccact cattacgaaa agtgggtctt
    21901 actgctaaag aaattaaaag gactttgtac attcaaattt cggtaatatt ctttgttcct
    21961 ttatcgttag ggggattgaa tttatttata gctactaatg ccttgcaaaa tatattagaa
    22021 ggaattacaa tttattctat aatagtaata tttttaatat ttggagtgtc tcagtttatt
    22081 atctatctta tttctagtta cttttactct aaaaaggttc tatgaaaaga tgatattttg
    22141 tctaggaggg tactaattta tctctcctag ataattaaaa tactaggggg gcggggaggt
    22201 atatacttat gcaagaaagt attcttgtag tcgatgatga gctggagatt gtagatataa
    22261 tctctgatat ctttgaagac cgaggttata gagttcttaa agcttataat ggggagcaag
    22321 cattagatca attaaagaca aatgtagatt taataatatt agatgttatg atgccccaga
    22381 tggatggttt tgatctttgt aaagttatca gagaacaaat ttattgtcct attctgtttc
    22441 taagtgcgaa gcactcagag atggataaag taaagggatt tactttagga ggagatgatt
    22501 atataacgaa gcctttccaa gtgaaagaac ttattgctcg ggtagaggcg cacttaagac
    22561 gtgaacagag ggatcgagtt agtactcaga atcaacgtct cttaggtaat ttaactatta
    22621 attattcaca acatgacgtt ttattggatg gtaaaaagat agacttaaca agtaaagagt
    22681 ttaagatatt ggaactttta acagtaaact taggacaaat attttctaaa gaacagattt
    22741 atgagaaaat ttggggtatt gatgcaatgg gtgacttaaa tactattata gttcacatta
    22801 ataatttaag agctaaattg acttcaggta tgtcaactta tcacattaaa acggtgtggg
    22861 gagtaggata taagttggaa aaacgttaat gattaaacgg ctatctttaa aaaatcagtt
    22921 tattttaacc tttgcttcag taatcttttt aagccttata agtacaattt gcagcttagt
    22981 tttattatat tattttctct ccgtttataa tgaaaagtca gtccaacctg ctaattatta
    23041 cgagaaaaaa gttcctagca tagaaaaatt tgttgagtta aaaggagaaa agatattaga
    23101 agtatctttt cagaaaaatt tagaaaaagt tattcctatg gaaggaatta catatcaggt
    23161 cataaacctt cgaggaaata aaatatatgg tacattagat gaccaattaa tagaaaataa
    23221 caaaagtata tatgaaaaag ttaatagatc cgatcaaaaa gggaaggtca taacgaaata
    23281 tcttcctatc ctcgacaaaa atcgaatgga aggagttcta gctgtacgat atgtgttagc
    23341 atcatctatt gactattata taaaatacat atttcttata atattattaa ttcctttttt
    23401 atttttaaca ctttactcat acgtatttgc gagacgtttt gggaaagaat taaataagcc
    23461 gattaaagaa ctgagtgctg cttctcagaa aattaaaaat caagatttgg attttgagat
    23521 taaatatgag agtgaaaatg aaataggtgt attaattgac tcttttaaca gtatgaaaga
    23581 agagttgaaa acgtcacttt atcttcaatg gaaattagaa caagagcgtc gagatatggt
    23641 tgcctcgatt gcccatgatt taagaacgcc tctaacaatt atattatccc atgtagaggt
    23701 cttaatggat ccatcattaa atggacagaa gcgtttgcca caatatttgc aaacaataaa
    23761 aaataatacc caaagagtat tgcatttgac agaggaaatg aaaagagtgt ctgaggtaga
    23821 taatccagat tttacacttg atattgaagg tgttattcct atagaaatgt taccggaaat
    23881 gctagaggaa tttaaaaaat gggcagagga tgaagaaata aagttcactt acagcttgaa
    23941 tagaaagcct ggagagggaa attccgaatt tgcattagat ccaaaacgat tgcatcaaat
    24001 tctgactaac ttaatttcta acagcattcg ttttacccca gtgaatggga gtatcgatgt
    24061 tcaagttcag atagagaaag atatgatgtc tttttctatt tccgatacgg gaaaaggatt
    24121 taataccaaa gatttacctt ttttattcag taaattctat caaggagatc cttcaaggaa
    24181 tgaccaactt caccatgggt tggggttata tattgtaaaa gagttagtta taaaacatgg
    24241 tggagaaatt catgccagaa ataatgaacc tcaaggagca tgtattgaat tcaccatatc
    24301 ttccataaat aaataaaaaa tgaactatga gtatcatagt tcatttttta tttatttaac
    24361 cgcgttgtat acatccagtt gaccatttcc ccaataagct aaattaggtt caatatcttt
    24421 ttttactccg tttttgtata gataatcaat ggagttactt ggacggtttt tgtagtgacg
    24481 ttggtcgata attaaggcga gggtagcaga aaccttgggt gcagccatcg aagttccaga
    24541 agcaaataaa tatcttccag tgttaaaagt agttaatact tgttcttgtc ggaaaagtcc
    24601 accatcccac catgcctctt ggccgtattt ctctaacaat ctagaatctc cccctggagc
    24661 agcgatatca atataatttt ttccgaaatt agagaataaa gaaagttgtt gcgtaggacc
    24721 agtagaagat actgtgacta caccaggcaa ttctcctgga gcttcaattc ctactccgtt
    24781 aaatgttttt ccttcttccg catatttttt cttaagaaaa tcattcagct ctgatttgtt
    24841 ggaaacatct attgagtcat tgcctgcaga agcaactacc acactaccta acttattagc
    24901 atactcaatt gcaagtttat atccttcaac atctgcccac ttattatcta aaagttcacc
    24961 atctttatat atgttaccat caatataata agaaccaagg ctaagattaa tgacatccac
    25021 gtcatcttta gctgcttgaa taattgcttt gatgatccac acagcatcag ctgacttatt
    25081 accgaataca cgatatactt taattcctgt attcggtgct acccctttaa tttcaccatt
    25141 ggcagcaata gatccagcta ccatagttcc atgtccatta atatcgttaa tactattaat
    25201 atcgcctgtt tcttcaggct ctgtccctct aagcccacct ttgggaacaa gattttttga
    25261 tccacttttc agattgtcta cgaggtctgg atggtcaatg tcaattccag agtcaacaat
    25321 tccaacagtt acattagaag aacctgattc tatgttataa ctttctccat tgtgcgtaat
    25381 ttctttcata tcccactgca tatcccataa ggcaggaaga gtgctatcta aaccttttat
    25441 tgagtttaca cttgaattag gttttttaaa agacttagat gtagaaggct tttctaattt
    25501 taaagaagga cttaaagatt taaataaaga agcatttgtt ttagccactt tttgatttcc
    25561 tttaaattga attagtccta tctcagggac ggtataagta atttctccct ggctcttttt
    25621 aatcttctta atagattgcg tccacttaga acggtctttc aagataactg tgtaatattg
    25681 atttgtttct gttttagcat gcccataatt agtaaaacaa aagcaaatta agagagtagt
    25741 aataatagtc atagaggttt ttttcataat cttctcctta tatttataat ttagaggtgg
    25801 aatccgggat tgaaccggag atcaaggttt tgcagacctt tgccttaacc acttggctat
    25861 tccacctaga tcctataaat ataagataac gaataatgat agatttataa tctgaatata
    25921 tcgaataaat aactagtata tcccgcaaaa cacataaatt ttataaagtt tgttctttac
    25981 tcctgtgtat tgctctttat atttctcgat aaaatgggtt aactcagttt tgactgggaa
    26041 gagatggact ttatataaat gcaggctcaa tgctaccaat tattgctggc ttaattgctt
    26101 gttatattgc tgaaaagata tatctgtaca aatataagaa aaagatagga caagtataag
    26161 agctagtaat ttataatcaa ttaacccaag tgtttcatac atatctagtt accataatca
    26221 aacttatgta aactctaaag aaaaaagcta ctcccttacc catggaagta gcttttcctt
    26281 agaacatcat acatgaagaa tagtaggaat tggggttcct atcctcttag tttgctctag
    26341 aagttgcatt ttattctttt attttaagta aaaaagagaa caccaaagga ataataacaa
    26401 gccttcatca tatcgcaaat ttttgcaatt ggtttgcata aaaaacagtc t
//
