LOCUS       NZ_CP072679            10831 bp    DNA     circular CON 26-AUG-2024
DEFINITION  Ferrimonas sp. SCSIO 43195 chromosome, complete genome.
ACCESSION   NZ_CP072679
VERSION     NZ_CP072679.1
KEYWORDS    RefSeq.
SOURCE      Ferrimonas sp. SCSIO 43195
  ORGANISM  Ferrimonas sp. SCSIO 43195
            Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
            Ferrimonadaceae; Ferrimonas.
REFERENCE   1  (bases 1 to 4795900)
  AUTHORS   Tang,K. and Wang,X.
  TITLE     Antagonism between coral pathogen Vibrio coralliilyticus and other
            bacteria in the gastric cavity of scleractinian coral Galaxea
            fascicularis
  JOURNAL   Sci China Earth Sci 63 (1), 157-166 (2019)
REFERENCE   2  (bases 1 to 4795900)
  AUTHORS   Tang,K. and Wang,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-APR-2021) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of
            Oceanology,Chinese Academy of Sciences, 164 Xingang West Rd,
            Guangzhou, Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. v3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 100x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023716685.1-RS_2024_08_26
            Annotation Date                   :: 08/26/2024 05:47:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,431
            CDSs (total)                      :: 4,267
            Genes (coding)                    :: 4,241
            CDSs (with protein)               :: 4,241
            Genes (RNA)                       :: 164
            rRNAs                             :: 10, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 10, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 131
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 26
            CDSs (without protein)            :: 26
            Pseudo Genes (ambiguous residues) :: 0 of 26
            Pseudo Genes (frameshifted)       :: 7 of 26
            Pseudo Genes (incomplete)         :: 17 of 26
            Pseudo Genes (internal stop)      :: 5 of 26
            Pseudo Genes (multiple problems)  :: 2 of 26
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:33:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1280244
            Orig. end                         :: 1291075
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP072679.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10831
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10831
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10831
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5831](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5831
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    18..34
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 22.46"
                     /tool="antismash"
     misc_feature    complement(782..795)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.28"
                     /tool="antismash"
     misc_feature    complement(1281..1295)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.09"
                     /tool="antismash"
     misc_feature    1430..1439
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     misc_feature    complement(3153..3162)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 16.86"
                     /tool="antismash"
     gene            complement(3204..4163)
                     /gene="dusC"
                     /locus_tag="J8Z22_RS06245"
                     /old_locus_tag="J8Z22_06230"
     CDS             complement(3204..4163)
                     /EC_number="1.3.1.-"
                     /GO_function="GO:0017150 - tRNA dihydrouridine synthase
                     activity [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_process="GO:0002943 - tRNA dihydrouridine synthesis
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="dusC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012324416.1"
                     /locus_tag="J8Z22_RS06245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8Z22_06230"
                     /product="tRNA dihydrouridine(16) synthase DusC"
                     /protein_id="WP_252009512.1"
                     /transl_table=11
                     /translation="MRVVLAPMEGVMDPLMRQVFTEIGGYDLCVTEFVRVVNQCLPEKV
                     YRRLCPELAQGGATLAGTPVRVQLLGQSPEWMAENAAFASELGSPGIDLNFGCPAKSVN
                     RSNGGAVMLKTPEQLHQVVKAVRAAVPAHLPVTAKVRLGWDSCDNAMEIADAAASGGAD
                     ELAIHARTKADGYRAERINWARIKPIAQALSIPVVANGEIWNRQDALNCLDQSGCQDIM
                     LGRGALAVPNLAKVVRGEQARYDWHQVVALMANYAQREIDGEKWIYFPNRIKQWLRYII
                     MQYPEAEPFFCQLRVLRDVDEIIATLYKEGERAQRALA"
     misc_feature    4273..4289
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 20.64"
                     /tool="antismash"
     gene            4399..4818
                     /locus_tag="J8Z22_RS06250"
                     /old_locus_tag="J8Z22_06235"
     CDS             4399..4818
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004588128.1"
                     /locus_tag="J8Z22_RS06250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8Z22_06235"
                     /product="hypothetical protein"
                     /protein_id="WP_371878108.1"
                     /transl_table=11
                     /translation="MKKTTVAAALGLCVAGTAMAANAADANPFAAQELTSGYQLDGDKH
                     KEGKCGEGKCGGEKKAGEGKCGEGKCGGEKKAGEGKCGEGKCGGEKKAGEGKCGEGKCG
                     GEKKAGEGKCGEGKCGGEKKAGEGKCGEGKCGGAA"
     misc_feature    complement(4899..4913)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.88"
                     /tool="antismash"
     gene            5001..5831
                     /locus_tag="J8Z22_RS06255"
                     /old_locus_tag="J8Z22_06240"
     CDS             5001..5831
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018693173.1"
                     /locus_tag="J8Z22_RS06255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8Z22_06240"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_245595606.1"
                     /sec_met_domain="DUF692 (E-value: 4.7e-106, bitscore:
                     351.9, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISGAGLGLKREMVEEFVTEGLPSSINFLEVAPENWLKVPPRLAR
                     KFRSLTEQYPFVCHGLSLSIGAPAPLDIEFVKQVKRFLDTHGIDLYSEHLSYCSGNAHM
                     YDLMPIPFTEEAVDHVAARIRTVQEIIERPLIIENVSYYAEPGAEMEEVTFINEVLKRA
                     DCKLLLDVNNIYVNSINHNYDADEFLQGIDGSRTAYYHVAGHYKEADDFLVDTHGAPVN
                     DPVWGLLQRAYQLHGIHPTLLERDFNLPKTSELVGEIDRIHEIAADVKGVKQSA"
     gene            5828..6574
                     /locus_tag="J8Z22_RS06260"
                     /old_locus_tag="J8Z22_06245"
     CDS             5828..6574
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF046510.1"
                     /locus_tag="J8Z22_RS06260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8Z22_06245"
                     /product="DUF2063 domain-containing protein"
                     /protein_id="WP_252009514.1"
                     /transl_table=11
                     /translation="MIDFKALQQEFMAHIRDPQQPAPQRVPAPRMAVYRELMLNNVGSF
                     IDSGFPVLKSLYSESDWRALRERFFAHHDSHSPLFVDIAAEFLVYLDGLKQLQPNDPPY
                     MRELAHYEYLELKLDVMPEAEHQQPLSVQDDLVTTPLLLNQVAEIGQYRYPVQHAAAHQ
                     RELEPVETLLLVYRNPELEIAFMAVNAMTVALLAQLSVDKPTTLAAIIEAMQQQFDQFA
                     ADVIEQGVIQMLGQLARCGVVVKPLG"
     misc_feature    6575..6593
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.04"
                     /tool="antismash"
     misc_feature    complement(6660..6675)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.67"
                     /tool="antismash"
     gene            6735..7130
                     /locus_tag="J8Z22_RS06265"
                     /old_locus_tag="J8Z22_06250"
     CDS             6735..7130
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012301.5"
                     /locus_tag="J8Z22_RS06265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8Z22_06250"
                     /product="response regulator"
                     /protein_id="WP_051252772.1"
                     /transl_table=11
                     /translation="MTKRIMVVDDNAASRAKIEQALIEAGMMVMTAENGMQALLLAKNE
                     AIDGVVTDQVMPMMDGAHLTRMLREIPAYKRIPIVLLTTESGRDFMEQLDDCGVPVWLE
                     KPLTEQKLALIAAEMLHPSVATKTKAA"
     gene            7250..7795
                     /gene="apt"
                     /locus_tag="J8Z22_RS06270"
                     /old_locus_tag="J8Z22_06255"
     CDS             7250..7795
                     /EC_number="2.4.2.7"
                     /GO_function="GO:0003999 - adenine
                     phosphoribosyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006168 - adenine salvage [Evidence IEA]"
                     /codon_start=1
                     /gene="apt"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011759425.1"
                     /locus_tag="J8Z22_RS06270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8Z22_06255"
                     /product="adenine phosphoribosyltransferase"
                     /protein_id="WP_028113791.1"
                     /transl_table=11
                     /translation="MNQDKLTLIKDSIKTVPDYPKPGIMFRDVTSMMESAEAFTASIEL
                     FAEEFRDAGITKIVGTEARGFLFGAPLAIALGVGFVPVRKPGKLPRKTIGQSYELEYGQ
                     DTLELHVDAIVPGDKVLVVDDLLATGGTIEATVKLIRSLGGEVDHSAFVISLPDLGGEK
                     KLEALGLTITKLCEFEGD"
     misc_feature    7265..7278
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     gene            7908..10283
                     /gene="dnaX"
                     /locus_tag="J8Z22_RS06275"
                     /old_locus_tag="J8Z22_06260"
     CDS             7908..10283
                     /EC_number="2.7.7.7"
                     /GO_component="GO:0009360 - DNA polymerase III complex
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /gene="dnaX"
                     /inference="COORDINATES: protein motif:HMM:NF005942.0"
                     /locus_tag="J8Z22_RS06275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8Z22_06260"
                     /product="DNA polymerase III subunit gamma/tau"
                     /protein_id="WP_252009515.1"
                     /transl_table=11
                     /translation="MAYQVLARKWRPANFEQVVGQQHVLRALTNALEHDRLHHAYLFTG
                     TRGVGKTSIARLFAKGLNCEQGITATPCGTCSACQEISQGRFVDLMEIDAASRTKVDDT
                     REILDNVQYQPTRGRFKVYLIDEVHMLSRHSFNALLKTLEEPPPHVKFLLATTDPQKLP
                     VTVLSRCLQFNLKSLSSEKIAAHLETVLKGEEVAFEPQALNLLAQAADGSVRDAMSLTD
                     QAIAHGNGGIALAEVQAMLGTLDSSYSLNLLHALVAGDLQGVMSTLAEIDQFAPDYDEL
                     LKQLLELLHNVAMTQFSVTASKLQPHSQALLQLATRLSREQVQLWYQMLAEGRRDLPLA
                     PEPRSGLEMTLLRTLAFSPVTEIEPLAPGLPVTPAARPEPQAPQAPAQSEPAAAQSVEP
                     APQPAPQPAVQAQESEPDAELGTAAPSSQAPGSDDPQVLAAEQQMLMMQAQQLHGNLDY
                     DDAEAPMSAAQQMEELQAQALSPTPPQPAVVGDEAPNSPPAQPAAAAESPMSLLERAMA
                     NRERLAARSRPAEDNPSKKPSPQAGAEPRSQRPIPPKPSVSRSQPPMDAVPEPVTEPVS
                     APSESNADSAPPWDNESTPAVTIQAPEAATAPAVESGTEVSPLAPPPSVPQSEAPQSEV
                     LQSEAPQPEVEPTAATVAAADVSGRADDQQWYQAIFELGVMARARQLAINSLMDRQGDT
                     IRLLLKPEQRHLMHESVVGQIRDKMVAVWQAPIELKIEIGEDRQRETPLEIRRRLHKER
                     LAEAKVNLLDDPHVSWMMAELDAELIDESISYTQAENK"
     gene            10392..10721
                     /locus_tag="J8Z22_RS06280"
                     /old_locus_tag="J8Z22_06265"
     CDS             10392..10721
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020431703.1"
                     /locus_tag="J8Z22_RS06280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8Z22_06265"
                     /product="YbaB/EbfC family nucleoid-associated protein"
                     /protein_id="WP_028113789.1"
                     /transl_table=11
                     /translation="MFGKGGMGNLMKQAQQMQEKMQQAQAEIANMEVTGESGAGMVKIT
                     MTGSHSVRRVEIDPSLMEDDKEMLEDLIAAACNDAARRVEETSKEKMGALTGGMSLPPG
                     FKMPF"
     misc_feature    complement(10782..10791)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 17.71"
                     /tool="antismash"
ORIGIN
        1 gagttttagt agtggccttg gaaatttgct accggccagt ggcactgcgt tgaccgacag
       61 cgacggtcga gcctcgattt tactgcaggc cggcagtgtg cagggggcgg cagagttgga
      121 ggccagtttt aatggccaga gtgcgcgcct cggttttgtc accttagggg atgagatcga
      181 tccggcactg gtggtgcccg atatccaggt gcagctgtac gactgccagg acagtcctgg
      241 ttgggatcgt aacctgaaga acttcgaggc ctgcaccagt accaccaata ttaccaacac
      301 ccgggcgggg atcatcggca tcgaggtgac tcaaagcggt ggcattcaac ctctggcaca
      361 gcgcctggtc agtgccacca ccagcatcgg cgccgtcagc ccggcggcgg gcactgccat
      421 cactaatgcg caggggcggg cgttgctgga tctctatgcc gatggcgatg tgggggccgg
      481 agagttaacc gtaagcttgc aaaatcagtc tcatacgctg gcgtttgagg taggacgggt
      541 cagtgtggat ctggatgttc aaacccgatt gggcaagggg gccctgcctg ccggcggcag
      601 caccattatc gaggtgcgca ttctcaatgg cgacggctca ttggcactgg atcaacctct
      661 gcaactggag ttgagttccc aatgcatgtc ggcagggctg gcacacatcg atacacccat
      721 tacgacggtc gctggcgtgg gcctggccac ttaccgcgcg gcggggtgtc aggggcagga
      781 cttgatctcg gtcagcgcca agaccggcgg cagtaccgtg gtgggagaga ccgaagtgga
      841 ggtcagtgcc gcggccatcg gctcattgca gtttctcgag gtgtcgtctt ccttgctggc
      901 gctgaagggc accggtggca ttcagggcgg aggcctgcgc agcgaaactt cggtggtgcg
      961 gtttcgcttg ttggatcgca gtggcaaccc tgccggccag caacgactct gttttgagct
     1021 cagtaccaac gttggcgggt tgagtctgag cccggacccc ctgcctcagg atctgaccga
     1081 ttgccccaat atcgataaca gtagcaccga actgactcag tacgccgtgg gcgataccga
     1141 tgccaacggc gaggtggcgg tgaccgtcgg cgcaggcacg gtggccacgc cggtgaaggt
     1201 attcgccttg tggtctgatc cgcagaaccg cgacatcgtg atagccaatg tgtcggataa
     1261 cctggtgata accaccgggc tggccgacga caacagcacc tccttgagtg cgtcggttct
     1321 gaacccggaa gcgctgagta ttgacagtca ggaggtggac attcacctgc tggcggcgga
     1381 tcactttaac aatccggtac ccgacggcac tgcggtgacg tttcgagccg aaggcggcgc
     1441 catcgatggc agttgcatca ccgggcctaa ggatgatcgc cccaatccgt ctggcggctg
     1501 ctcggtgcag tggcgcagcc agaacgccag gcccttctat gacggtgcag cagcagtgtg
     1561 tcctgatggc agtgatgcca cgcctccgtg tttaggggcc acattggagg cgcactacca
     1621 aggtgttggt tcagtgattg ccgagcctcg tccggggcgg gcaacggtca tggcaatgct
     1681 gattggtgaa gagagttttg tcgatctaaa cggcaatggc ctgtttgatg gtgcgccgga
     1741 gaccttcgtg gatttgactg aggcctttat ggatgacaac gaggacgggc gctatcgcaa
     1801 ctaccaggcg gacggcctgg ctgcggtagg cagtgtccca gctggtgcgg tgaatgagga
     1861 gtttgtcgat tacgatggtg atgaggcgtt tgatggggtc gacggtgtct ataccggttt
     1921 gctgtgccac cccgaggcat cgtcacagtg cgtggatacc ggcctggacc ttgctaaggc
     1981 gcagttgcac ctgcgccgca acctgacgct ggtgatgtct ggcagcgtgc cgtacggcaa
     2041 actgcgccag tggggaagtg ggggcagttt aaacccggtc agtgccttgg atctggtcac
     2101 caacagcaag gagaccgtac tgctgttttt gtctgatgcg aataacaacc cattgcctta
     2161 cggcaccacg attacagcgt cgacctcaaa tggtgagctt gttggtgcga cccaatacac
     2221 catgggcagt agcaactcga tgattccttt ggtctttagt tttacggtag agcgagaaac
     2281 aaaccccaat ggccgctccg aagggacatt gagtattctg gtgcaaacgc cgctcggcaa
     2341 cccggcttcg ttttctgtgg ccgttgaaga cggtggctga tgagaggaac ccagtgtagt
     2401 tgaggtttta aagccactgg gccctcgcgt tcgcaagggc gacggtgcga gttggatggg
     2461 tttgcggtaa atctgctcta ccgtagcgac ggcagagctc agcattggtg gttaccactc
     2521 aacgcccaat catccctctg tcgtgcccgc gcacgcgggt acccagtgtc tttttttcac
     2581 aatcaaattc aaagccactg gaccctcgcg ttcgcaaggg cgacggtgct agttggttgg
     2641 gtttgcggta attgagtcgt taccgtggtt tcagcaacgc tcggtatcgt tcgttacctt
     2701 cgcactttaa tcatccctcc gtcgtgcccg cgtacgcggg tacccagcgt ctttttttca
     2761 caatcaaatt caaagccact gggccctcgc gttcgcaagg gtgacggtgc gagttggatg
     2821 ggtttgaggt aattgagtcg ttaccgtggt ttcagcaacg ctcggtgtcg ttcgttacct
     2881 tcgcacttta atcatccctc cgtcgtgccc gcgcacgcgg gtacccagcg tcttttttca
     2941 caatcaaatt caaagccact ggaccctcgc gttcgcaagg gtgacgggat ggaggaggtg
     3001 accctcgcgt tcgcaagggt gacgggatgg aggaggtgac cctcgcgttt gtaagagtga
     3061 caggatggag gggggggcca tcgcgttcgc aagggtgacg ggatggagga ggtgaccccg
     3121 gcgttcgcaa ggacgacggg tttgaggaaa gataaaaaaa cgcctctata tatagaggcg
     3181 ttattgagtt tggtgacggg gactcaggcg agggcgcgct gagcccgttc tccctcttta
     3241 tatagagtgg cgatgatctc atcgacgtcc cttagtaccc gtaactggca gaaaaagggt
     3301 tcggcttccg ggtactgcat gatgatataa cgcagccact gcttgattcg attggggaaa
     3361 tagatccatt tctcgccatc gatttcccgt tgagcgtaat tggccatcaa cgccaccacc
     3421 tggtgccagt cgtaccgagc ctgttctccc cggaccactt tcgccaggtt gggcaccgcc
     3481 agggcgccgc gacccaacat gatgtcctgg cagccactct ggtcgaggca gttgagggca
     3541 tcttgtcggt tccagatctc accattagcg accacaggaa tcgacagggc ctgggcgatg
     3601 ggcttaatcc gtgcccagtt gattcgctcg gcccgatagc cgtcggcctt ggtgcgggcg
     3661 tgaatggcca attcgtcggc gccgccgctg gctgcggcat cggcaatttc catggcgttg
     3721 tcgcaactgt cccagccgag gcgcactttc gcggtaacgg gcaagtgggc cggtaccgcg
     3781 gcgcgcaccg ctttcacgac ctggtgcagc tgttccggag ttttcagcat taccgcgccg
     3841 ccattggagc gattcacgga tttagctgga cagccaaaat taagatcaat gcccggagag
     3901 cccagttctg aggcaaaggc ggcattttcc gccatccact caggggattg ccccagcaac
     3961 tgaacccgca ccggggtgcc ggccagtgtg gcgcccccct gggccagttc agggcacagt
     4021 cgacggtaca ctttttcagg aaggcattga tttaccaccc ggacaaattc ggtgacgcac
     4081 aggtcatagc caccaatctc ggtgaaaacc tggcgcatca atgggtccat gaccccttcc
     4141 attggtgcta atacgactct catgaccatc aaaacggatt aaaactcagg cgcgggagtg
     4201 tagcagttat ggccattttc agcatcccta acaggagttt cttgattaat aaagcagcaa
     4261 gatcaaaaaa agttgttata ttgtgaaata gatcctgatg tggctgggtc tcttatcgta
     4321 agccagcgaa atacgacgct gggttaacaa tggtttaagc atccgagata tgaaaggaag
     4381 ggtattaaga tgaattcaat gaaaaaaacc actgttgcag cagcgttggg cctgtgtgtt
     4441 gctggtactg ccatggccgc gaatgccgcc gatgcgaacc cgtttgccgc tcaagaactg
     4501 acctctggtt accagttgga tggtgacaag cacaaagagg gtaagtgtgg cgaaggtaag
     4561 tgcggcggtg aaaagaaagc cggcgaaggg aaatgcggcg aaggcaaatg cggcggcgaa
     4621 aagaaagccg gcgaagggaa atgcggtgaa ggcaagtgtg gcggcgaaaa gaaagccggc
     4681 gaagggaaat gtggtgaagg taagtgcggc ggcgaaaaga aagccggcga aggtaagtgt
     4741 ggtgaaggca agtgcggcgg cgaaaagaaa gccggcgaag gtaagtgtgg tgaaggcaag
     4801 tgcggtggcg cagcctaacg ccatacagat gctctgacac accgagtgag gctggcgtga
     4861 gtcagcctca ctgctatccg gtgttcagaa tcagattcat cgccattgaa gattggagcc
     4921 gagaaaactt cagtgcgcaa tggcgagcaa tctcaaacaa tcacaccgca gtaacgtgaa
     4981 cagcaatgag gagaaaggcg atgatctcag gggccgggct tggattaaag cgagagatgg
     5041 ttgaggagtt tgtgaccgag ggcctgccgt catccatcaa ttttttggag gtggctccag
     5101 agaactggct caaggtgcct ccccggttgg cacgcaagtt tcgttcgctg accgagcagt
     5161 acccctttgt gtgtcacggc ctgtcgctgt ccatcggtgc cccggcgcct ttggacatcg
     5221 agtttgtcaa acaggtgaag cgctttctcg atacccatgg catcgacctg tattccgagc
     5281 atttgagtta ctgctcaggg aatgctcata tgtacgatct gatgccgatc cctttcaccg
     5341 aagaggcggt ggatcacgtt gcggcccgca ttcggaccgt gcaagagatc atcgagcggc
     5401 cgctgatcat cgaaaatgtc tcctactacg ccgagcccgg ggctgagatg gaggaggtga
     5461 ccttcatcaa tgaagtgctc aaacgagcag actgcaaact gctgctggac gtgaacaaca
     5521 tctatgtgaa tagcattaac cacaattacg atgccgatga gtttctgcaa gggatcgatg
     5581 gcagtcgtac cgcttattat catgtggcgg ggcattataa agaggcggat gattttctgg
     5641 tggacaccca tggggcgccg gtgaatgacc cggtgtgggg actgttgcag agggcctacc
     5701 agcttcacgg cattcacccc accctgcttg agcgggactt taacctgccg aaaacctcgg
     5761 agttggtggg tgaaattgat cgcatccacg agattgccgc cgacgttaaa ggagtgaaac
     5821 agagcgcatg atcgatttta aagcgttgca gcaggagttt atggcccaca ttcgtgatcc
     5881 ccagcaaccg gcgccgcagc gggttccggc tccgcggatg gcggtctacc gggagctgat
     5941 gctgaacaac gtcggcagct tcatcgacag tgggtttccg gttttgaagt cgttgtacag
     6001 cgagtccgat tggcgggcgc tgcgggaacg ctttttcgct caccatgaca gtcactcgcc
     6061 gctgtttgtg gacatagcgg ccgaattcct ggtttatctg gatgggctga aacaactgca
     6121 gccgaatgat cctccttata tgagagagct ggcgcattat gagtatctgg agttgaaact
     6181 ggatgtgatg ccggaggcag agcatcagca accgctatcg gtgcaggacg acctggtgac
     6241 cacaccgctg ctgttgaatc aagtcgccga aatcggtcaa taccgttatc cggttcaaca
     6301 tgcggccgcg catcagcgtg agctggaacc ggttgagact ctgttgctgg tgtatcgcaa
     6361 tccggagctg gagattgcct ttatggcggt caatgccatg accgtagcgt tgctggctca
     6421 gttgtcggtg gacaaaccga cgactctggc ggcgatcatc gaggctatgc agcagcagtt
     6481 tgatcagttt gctgccgacg tgattgagca gggtgtgatc cagatgctgg ggcagttggc
     6541 ccgttgtggg gtggtggtca aacccttggg gtaatttgcg accgctactg aatctaggct
     6601 gaattggcgg tgaagttgtt tcaaacttaa tcagatttcg ccgaaatctc tgcaaccgct
     6661 gtgatcggca gcacatcacc cttggatggg gtttcgtacc atgcgcccat gataattgat
     6721 gttgggtgcg aaggatgacc aagcgaatca tggtagtgga cgacaacgcc gccagtcgag
     6781 cgaagattga gcaggcgctg atcgaggccg ggatgatggt aatgaccgcc gaaaatggca
     6841 tgcaggcgct gttgctggcg aaaaatgaag ccatcgacgg cgtggtgacg gatcaggtga
     6901 tgccgatgat ggacggagcg catttgaccc gaatgttaag agagattccc gcttacaaac
     6961 gcattcccat cgttctgctc accaccgaga gtggccgtga ctttatggag cagttggatg
     7021 attgtggtgt gccggtatgg ttggaaaaac cacttacaga acaaaagtta gcactaattg
     7081 cggcggaaat gttacatccg tctgttgcaa ccaaaacgaa agctgcttaa gctatagccg
     7141 aaaaaggtag tagtcataaa ggctcatctg ctgaacctta tttcagcaag tgggcttttt
     7201 tattgtgttt ttgccgccac aattgtggcg aaatggtaaa gccgtaacca tgaaccaaga
     7261 taaactgacg ctgatcaaag acagcatcaa aaccgtaccg gattacccga agccaggaat
     7321 catgttccgt gacgtcacct ccatgatgga gagtgccgag gcttttaccg cgtccattga
     7381 actgttcgct gaagagttcc gcgacgccgg tatcactaaa atcgtcggta ctgaagctcg
     7441 cggtttcctg ttcggtgcgc ctttggccat cgctctgggc gtgggttttg ttccggtacg
     7501 taagccgggt aaactgccac gcaaaaccat cggccagtca tacgaactcg agtatggcca
     7561 ggacacgctg gaactgcacg ttgacgccat cgtaccgggt gacaaggtgt tggttgtcga
     7621 tgacctgctg gcaaccggtg gcaccatcga agcaaccgtg aagctgatcc gctccttggg
     7681 cggcgaagtt gatcactccg cttttgttat ctctctgccg gatctgggcg gtgagaagaa
     7741 gctggaagcg ctgggactga caattaccaa actctgtgag tttgaaggcg attaacagtc
     7801 tgtcagctaa gccgggtttg atgcccggct tttttgtgcc tgctctcccg tggtaacctc
     7861 tctgtcttga tgaggcgatc cgcctccact ggattacggg aatcaccatg gcatatcagg
     7921 ttctggcgcg taagtggcgc ccggccaatt tcgagcaggt ggtggggcag caacacgtgt
     7981 tgcgcgccct caccaacgcc cttgagcatg atcgtctgca tcatgcctat ctgtttaccg
     8041 gcacccgagg ggtggggaaa accagtatcg cccggctgtt tgccaagggg ttgaactgcg
     8101 aacaggggat caccgccacg ccctgtggta cctgcagtgc ctgccaggag atcagtcagg
     8161 ggcggtttgt cgacctgatg gaaatcgatg cggcatcgcg caccaaggta gacgacaccc
     8221 gcgaaattct ggataacgtc cagtaccaac cgacccgtgg ccgcttcaag gtgtacctga
     8281 tcgatgaagt acacatgttg tctcgtcaca gtttcaatgc cctgctgaag acactggaag
     8341 agccgccacc gcacgttaaa ttcctgctgg ccaccacgga tccgcaaaag ttgccggtca
     8401 cggtgctgtc ccgttgtttg cagttcaatc tgaaaagcct gtccagcgaa aaaatcgccg
     8461 ctcacctgga gaccgtcctt aaaggggaag aggtggcgtt tgaacctcag gcgctgaacc
     8521 tgttggcaca agccgccgat ggcagtgttc gagatgccat gagcctcacc gatcaagcca
     8581 ttgcccatgg caatggtggt attgccctgg cggaagtgca ggcgatgctc ggcactttgg
     8641 atagcagtta cagcttgaac ctgttgcatg ctttggtcgc cggcgatctg cagggggtga
     8701 tgtcgactct ggccgagatc gaccagtttg caccggatta cgatgagctg ctcaaacagt
     8761 tgctggagtt gctgcacaac gtcgccatga cccagttttc ggttaccgcc agtaaactgc
     8821 agccccattc gcaggcgttg ttgcagttgg ctacccgcct gagccgcgag caggttcagc
     8881 tgtggtatca gatgctggcg gaaggtcgcc gggatctgcc gttggcaccg gagccacgca
     8941 gtgggctgga gatgaccttg ctgcgcacac tggcattttc accggtaacc gagattgaac
     9001 ctctggcgcc cggattgccg gttacgcctg cggctcggcc agagccccag gcaccacagg
     9061 ctccggcgca gtctgagcct gctgcggcgc agtcggttga accggcaccg caacccgccc
     9121 cccagcccgc tgtgcaggcg caagagtcag agcccgatgc tgagctgggg actgcggcgc
     9181 cgtcgtcgca ggcgccgggc agtgatgatc cgcaggtgtt ggctgccgaa cagcagatgc
     9241 tgatgatgca ggcgcaacag ctgcatggca atttggatta tgacgatgcc gaggcgccga
     9301 tgtcggcggc gcaacagatg gaagagttac aggcccaggc attgagcccg acgccgccac
     9361 agcccgcagt ggtaggggac gaggcgccga actcgccacc agcgcaaccg gcagcggccg
     9421 ccgaatcgcc catgagcctt ttagaacggg ccatggccaa tcgcgagcgg ctggcggccc
     9481 ggtctcgacc tgccgaggat aacccgtcaa aaaagccaag cccccaggcg ggggctgaac
     9541 cccgaagcca gagaccgatt ccgccaaagc cctctgtcag ccggtcgcaa ccgccaatgg
     9601 acgcggtgcc agagcctgtg acagagccgg tgtcggcgcc ttcggagtcg aacgccgatt
     9661 cggcgccgcc ctgggataac gaatcgacgc cagcagtgac gattcaggcc cctgaggctg
     9721 ctacggcgcc tgcggtggag tccggtaccg aggtgtcgcc attggcacca ccgccttcag
     9781 tgccacagtc ggaagcgcct cagtcggaag tgctacagtc ggaagcgcct cagccggaag
     9841 tcgaaccgac ggccgccacc gttgctgctg cggatgtcag cggccgcgcc gacgatcaac
     9901 agtggtacca ggcgattttt gagcttgggg tgatggcccg tgccaggcag ttggccatta
     9961 actcgctgat ggatcgacaa ggggacacca ttcgtctgtt gcttaagcct gaacagcgtc
    10021 atttaatgca tgagtctgtg gtcggccaga tccgcgataa aatggtggcg gtgtggcagg
    10081 cacccatcga gcttaagatt gagatcggtg aggatcggca gcgggagacg ccattggaga
    10141 ttcgtcgccg tctgcataaa gagcgcttgg ccgaggccaa ggtgaacctg ctggatgatc
    10201 cccacgtcag ttggatgatg gcagagctgg atgccgagtt aatcgatgag tccatcagct
    10261 acactcaggc tgagaataag tgatccagtc tgagtttctg agcggacgga gtaacaaata
    10321 gtattcgcca acggagctga atccgttaac atagcccctt tgtggctcag taagtataga
    10381 gagaaccgaa tatgtttggt aaaggtggaa tgggcaacct gatgaagcag gcccagcaga
    10441 tgcaggaaaa gatgcagcag gcacaggctg aaatcgccaa catggaagtg accggtgagt
    10501 ccggtgcggg catggttaag atcaccatga ccggcagcca cagcgttcgc cgcgttgaga
    10561 tcgatccttc cctgatggaa gacgacaaag agatgctgga agacctgatt gccgcggcct
    10621 gtaacgatgc agcccgccgc gttgaagaga cctccaaaga gaaaatgggc gctctgaccg
    10681 gcggcatgag cctgcctcct ggcttcaaaa tgccgttcta atgaagttca gtccactcgt
    10741 tgatgagctg atcaaaagcc tgcagtgtct accaggggtt gggccgcgtt cggcgcagcg
    10801 gatgacgttt cagttgttgg agcgggatcg c
//
