LOCUS       NZ_CP084530            28497 bp    DNA     circular CON 20-MAY-2024
DEFINITION  Paenibacillus sp. YPG26 chromosome, complete genome.
ACCESSION   NZ_CP084530
VERSION     NZ_CP084530.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus sp. YPG26
  ORGANISM  Paenibacillus sp. YPG26
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 3966665)
  AUTHORS   Ma,K., Chen,W., Yan,S.Q., Lin,X.Q., Liu,Z.Z., Zhang,J.B., Gao,Y. and
            Yang,Y.J.
  TITLE     Genome mining reveals polysaccharide-degrading potential and new
            antimicrobial gene clusters of novel intestinal bacterium
            Paenibacillus jilinensis sp. nov
  JOURNAL   BMC Genomics 23 (1), 380 (2022)
   PUBMED   35590262
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3966665)
  AUTHORS   Ma,K. and Yang,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2021) College of Veterinary Medicine, Jilin
            University, Xi'an Road 5333, Changchun, Jilin 130062, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT v. v5.0.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023704175.1-RS_2024_05_20
            Annotation Date                   :: 05/20/2024 03:35:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,770
            CDSs (total)                      :: 3,645
            Genes (coding)                    :: 3,614
            CDSs (with protein)               :: 3,614
            Genes (RNA)                       :: 125
            rRNAs                             :: 11, 11, 11 (5S, 16S, 23S)
            complete rRNAs                    :: 11, 11, 11 (5S, 16S, 23S)
            tRNAs                             :: 88
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 31
            CDSs (without protein)            :: 31
            Pseudo Genes (ambiguous residues) :: 0 of 31
            Pseudo Genes (frameshifted)       :: 17 of 31
            Pseudo Genes (incomplete)         :: 17 of 31
            Pseudo Genes (internal stop)      :: 6 of 31
            Pseudo Genes (multiple problems)  :: 7 of 31
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:27:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 453982
            Orig. end                         :: 482479
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP084530.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Yong-Jun Yang Lab, College
            of Veterinary Medicine, Jilin University, Changchun, China.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..28497
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="3"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..28497
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..28497
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:18497](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..18497
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            734..3922
                     /locus_tag="LDO05_RS02050"
                     /old_locus_tag="LDO05_02065"
     CDS             734..3922
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040416.3"
                     /locus_tag="LDO05_RS02050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LDO05_02065"
                     /product="glycosyltransferase"
                     /protein_id="WP_251377262.1"
                     /transl_table=11
                     /translation="MNPFAPIQQQIYTRARHGIFRQTEGFDTVARSEGLEASFIKKVLH
                     PFCVYDAPAELAARGEKDNLAYPGAIHLFHAENGDTVLGRSIYQAADFTGLRSALFSHN
                     YVIPSSRSEELVQNYRSYLHADFLDHYDIGQSGQIPELNQIPVDQASLGSDRVKPAQLL
                     GELHIPEAMFKQLLAAVMTSVAGGRKVYIALDVPASYISEAAVPLLELLYAALPYAYRR
                     KLGFLTYAKEPQSRKGIHISFVERGSLRHGDRSIEKDYTFDLASGRVTNMELDWTKQPY
                     LDLVWSRIGSLDHLEDFHRFADIMLKDMGPEKPMSISSYHELSVLYRIEGGDEALYERH
                     KIAALSGMLEYLRPAGALPVKERLSDLFLARFDREFDIVKSGKVPDLAVAECIKDYYRI
                     DPKNNERKIVEYFIRAAVNAIKDKAAFAGLYALIENHPSLRKAYFDQVQKDDQLSALLL
                     VPYIQGRLQAAEKPREVVSLVQEWDRLSPGMWDKFALSELARSGLTGKLKVQQDLVASV
                     NEVLHMLGAHPGPAQEKGQYGEWEEQKRQLKMRQQGEADGAPGRQENDSWSMLSKPARG
                     QVMDEFESKDATGQFGREGSGISAVLAETARRVLLIELDLNKLTKEELLSLDWLKSANP
                     ACGPQRLDGQLRSKLAKLQSLYAWFSEAEPDVHVFDGLKPAEMDEVQKAGRRWLRDEVN
                     ADRFDRLTLAYYRGGAEDCMDYAPLVDALRKYAGSPDIVYRFFHWSAGQPLYVRGSKLA
                     PAYEAAILAYFRKYDRDAFKKRANRKEHFDKAGRALRPVYERAGQELASPLMRMFGRGG
                     KPMLFSVFILLLLAAGTLGILQLTGAFDKKEPAAVVPPVVDKPDVTEPAPSVSIPDRAV
                     YTEQVKDKSGKEVTRLVFLFRTSSECKSFNPGSVTVTTPGAKATSQNLKLSNLAHDCGT
                     GDSEETGVSAAGSTDSGHSSGLESGNKKSAGAEEGSVSSENDRLAQSSVDGQDDNEAGL
                     SVDGEGSSTQTGTQNAGVSSGESSSSSSIDPDVYPNKLTAALGKAYSIPEGSRISAAGL
                     EFVRISKTAAGKEQ"
     misc_feature    4716..4729
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.86"
                     /tool="antismash"
     regulatory      5044..5143
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            5264..6703
                     /locus_tag="LDO05_RS02055"
                     /old_locus_tag="LDO05_02070"
     CDS             5264..6703
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009223923.1"
                     /locus_tag="LDO05_RS02055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LDO05_02070"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_251377263.1"
                     /transl_table=11
                     /translation="MSKYDVIVVGAGPAGIFACYELSLKAPHWKVLLVDKGHDIYKRRC
                     PILEEKIKLCPPAAGKKEFAGCLPACSITAGFGGAGAYSDGKFNITTEFGGWMTDYISP
                     SKVLELIKYVDAINLGHGATTNVTDPMTDVIRGIEQRGYAAGLKLLRAQVRHLGTEQNL
                     EILKSIYEYLRTRIDMSFKTEVEDIITTKDEAGGLRIGGITLRSGEVHEADLVMIAPGR
                     DGSAWLTEILKRRRLKMYNNQVDVGVRVETSDVVMREINEHLYEGKFIYNTSVGTRVRT
                     FCSNPSGHVVVENHSGVMAANGHSYKDPALGSANTNFALLVSHKFTEPFDKPNEYAREI
                     CQRANDLSNGGVIVQKYGDIIRGRRSTESRISEGFLEPTLKEAVPGDLGLVLPYNTMKS
                     LIEMVEALDKVTPGIASEHTLFYGVEAKFYSARPKLDAALETEIKGLYCGGDGAGITRG
                     LAQAGAAGVWIARGMMEKAGI"
     CDS             complement(6710..6874)
                     /gene="allorf_0460692_0460856"
                     /locus_tag="allorf_0460692_0460856"
                     /protein_id="allorf_0460692_0460856"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MKVQVLILVKMISQASHIIPLYKYVLSKNLLEKKHRPAASRSCMA
                     VLSHILDAI"
     CDS_motif       complement(6758..6874)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MKVQVLILVKMISQASHIIPLYKYVLSKNLLEKKHRPAA"
                     /locus_tag="allorf_0460692_0460856_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(6710..6757)
                     /prepeptide="core"
                     /locus_tag="allorf_0460692_0460856_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.90"
                     /molecular_weight="1561.9"
                     /monoisotopic_mass="1560.8"
                     /core_sequence="SRSCMAVLSHILDAI"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKVQVLILVKMISQASHIIPLYKYVLSKNLLEKKHRPAA"
                     /leader_location="[6757:6874](-)"
                     /alternative_weights="1579.9"
                     /alternative_weights="1597.9"
     misc_feature    6930..6943
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: strong, score: 26.33"
                     /tool="antismash"
     gene            7003..7224
                     /locus_tag="LDO05_RS02060"
                     /old_locus_tag="LDO05_02075"
     CDS             7003..7224
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LDO05_RS02060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LDO05_02075"
                     /product="hypothetical protein"
                     /protein_id="WP_251377264.1"
                     /transl_table=11
                     /translation="MLEKFPLEIYSGYFSHYDESFEWKWFHEQETGLYLIVIFLSGWIP
                     TLKVSKEDLINFGAHILKEFESAPEYSN"
     CDS             7365..7508
                     /gene="allorf_0461347_0461490"
                     /locus_tag="allorf_0461347_0461490"
                     /protein_id="allorf_0461347_0461490"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MLKMKEVLSFLPIDLKEWSKAETWGLLQKSPGSIPISESICTPPD
                     IL"
     CDS_motif       7365..7463
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MLKMKEVLSFLPIDLKEWSKAETWGLLQKSPGS"
                     /locus_tag="allorf_0461347_0461490_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       7464..7508
                     /prepeptide="core"
                     /locus_tag="allorf_0461347_0461490_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.00"
                     /molecular_weight="1443.7"
                     /monoisotopic_mass="1442.8"
                     /core_sequence="IPISESICTPPDIL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLKMKEVLSFLPIDLKEWSKAETWGLLQKSPGS"
                     /leader_location="[7364:7463](+)"
                     /alternative_weights="1461.7"
                     /alternative_weights="1479.7"
     gene            complement(7740..8483)
                     /locus_tag="LDO05_RS02065"
                     /old_locus_tag="LDO05_02080"
     CDS             complement(7740..8483)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.4"
                     /locus_tag="LDO05_RS02065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LDO05_02080"
                     /product="ABC transporter permease"
                     /protein_id="WP_251377265.1"
                     /transl_table=11
                     /translation="MNNYLRSELYRIKSKKLIYLLPFLLAAIPLLGIFLVWSVGRSDPS
                     FTYNSTGFLYRFCRISFNNLVLLLPFLTIYLFASEYSSGTFKNVVASGISRRHIYLSKI
                     TVIFCILVLLSVIDIAMIVSAIELLLNHKDLGEKTLFYQNIIQTMPLFIAAYSISIMLC
                     FTEEKIVSNLVKYFLIIYIIPVFLGNFENIIPGLKSLLHIFPVIRLSEGLPFTMENLLF
                     NWLEALVYFVAAFVIGLSIFNKKEI"
     gene            complement(8452..9393)
                     /locus_tag="LDO05_RS02070"
                     /old_locus_tag="LDO05_02085"
     CDS             complement(8452..9393)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="LDO05_RS02070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LDO05_02085"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_251377266.1"
                     /transl_table=11
                     /translation="MRAVIEVENLTKQYRSIMALDHVNLHIQEGEIYGLIGKNGAGKSS
                     LLRILCGQSTRYSGSVKLFGHTVKQDSNERKRIGALIEYPAFYPELTGRQNLEYYRIQR
                     GISQKGAVEKVLNDLNLVPLADRKFKQYSLGNKQRLGIALALLDNPRILILDEPTNGLD
                     PIGIKEIRRLLLSINREHNITIVISSHILSELEQVISKVGFIDNGKLIQELTMDELRTK
                     CTRSVRLKVSNYDKIHLLLRNHLNNCEIRLLDNSEIQLSGDHLEISDITKLILDAGEKI
                     HSVHESHDSLEDYFFQLVGGAEHEQLSEKRTV"
     CDS             complement(9499..9609)
                     /gene="allorf_0463481_0463591"
                     /locus_tag="allorf_0463481_0463591"
                     /protein_id="allorf_0463481_0463591"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRLKSPFCIIIFYFFIIINYTLHGSSCKYWIASLLP"
     CDS_motif       complement(9535..9609)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRLKSPFCIIIFYFFIIINYTLHGS"
                     /locus_tag="allorf_0463481_0463591_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9499..9534)
                     /prepeptide="core"
                     /locus_tag="allorf_0463481_0463591_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.60"
                     /molecular_weight="1244.5"
                     /monoisotopic_mass="1243.7"
                     /core_sequence="SCKYWIASLLP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRLKSPFCIIIFYFFIIINYTLHGS"
                     /leader_location="[9534:9609](-)"
                     /alternative_weights="1262.5"
     misc_feature    9556..9569
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 21.35"
                     /tool="antismash"
     gene            9727..9933
                     /locus_tag="LDO05_RS02075"
                     /old_locus_tag="LDO05_02090"
     CDS             9727..9933
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_ha"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF000539.0"
                     /locus_tag="LDO05_RS02075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LDO05_02090"
                     /product="plantaricin C family lantibiotic"
                     /protein_id="WP_251377267.1"
                     /sec_met_domain="mature_ha (E-value: 4.7e-11, bitscore:
                     39.9, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLENRNPFIVFNQEAKMEALSPVLAEELIEVDLSIQGGCTTNTFT
                     LSNYLGNNGGWCTLTKECQRSCN"
     CDS_motif       9727..9840
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MLENRNPFIVFNQEAKMEALSPVLAEELIEVDLSIQGG"
                     /locus_tag="LDO05_RS02075_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9841..9933
                     /prepeptide="core"
                     /locus_tag="LDO05_RS02075_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.80"
                     /molecular_weight="3186.5"
                     /monoisotopic_mass="3184.4"
                     /core_sequence="CTTNTFTLSNYLGNNGGWCTLTKECQRSCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLENRNPFIVFNQEAKMEALSPVLAEELIEVDLSIQGG"
                     /leader_location="[9726:9840](+)"
                     /alternative_weights="3204.5"
                     /alternative_weights="3222.5"
                     /alternative_weights="3240.6"
                     /alternative_weights="3258.6"
     gene            10001..13024
                     /gene="lanM"
                     /locus_tag="LDO05_RS02080"
                     /old_locus_tag="LDO05_02095"
     CDS             10001..13024
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="LDO05_RS02080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LDO05_02095"
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_251377268.1"
                     /sec_met_domain="DUF4135 (E-value: 2.9e-71, bitscore:
                     238.4, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1e-53, bitscore:
                     180.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLSKEEVLPFWKSLLGIQSEEKLESHLESFFGEPIDIQVDNINK
                     ENEMKALGISRIQESSRKQNFFAKELDYFSLKLTELVEASAVIEDKEHFIDSQKEQLEK
                     ILENDLWYFLIDEATLYFNDKKDSIKNKNGEEMLKIFIEEVFHTERFRSQCEVLYLELF
                     PLISLRINNYLSYVEEIISNVTIDLHNIEGLLPSAHSPLQLNDVKLGSGDTHSDGKSVG
                     KLIFNRGVVYYKPRTGELDIKFFDFLDKLYLQDEKFDFKRIKIISRDTYSFFEQIDHVL
                     VRDSGELEQYYEKLGYLLCIMYTLNGTDFHSENIIAHGKDPVLVDLESLFHSNIFLNEN
                     LYDQGFLEIIKSSDPTVLDIGILPKKIVKNYDSDDYSLEIGGIGAEKQKVSPFKFSEFS
                     IDDQGQPRHIRKFGFNGVSENNPIKEISDSELSAINLIMQNSFEYFYKWILNNKSLYIS
                     MVNDHFKSKKIRVILRPTFLYSKLMILSKNIYFLGNRTNRKILFSKLAYERENQMSFVY
                     SEYDQLMNYDIPIFYAYTDELEIYNARNDKLGALSDKTPLESTILKIEKMSPDDLDNQK
                     ILIDQAMRLKEYKGDRTDIKFAPAAAAVDEIDSERAHQLCENIGNLLMRRAVYPNDESI
                     TWISTTILGKEESEFGVGPVGNDMYLGNAGITLFLAHLYKFTKNEKYKETVLKAVHYNI
                     RFLQQEKLYENGNIGYYNGTSGLLLSIGVINTIIPIPNFHSIMITSLERLMKLVKNCNN
                     YDIFAGSSGLITSLIALDKLYPEYRAYIRPLLEEAYRNLLGNAVRENNMCYWKNKNTLA
                     YVGYAHGNAGILAALIKLQAVEQEILGYQLVDSQFLLEISNYIDSAYNEQANNWENIPG
                     SKKYSHGWCHGAQGLLLAQVIAKENHSASLRDEDYISNLVEITMQHGFGANPSYCHGDL
                     GSLKIIEKYAQVFGKEDLLKQCLQTYASIFYNTIEKKWEKQVLSHSESLGLLIGVSGWG
                     YSVLQYLYPDQVFDFFTL"
     misc_feature    10034..10048
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.67"
                     /tool="antismash"
     gene            13115..15265
                     /locus_tag="LDO05_RS02085"
                     /old_locus_tag="LDO05_02100"
     CDS             13115..15265
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="LDO05_RS02085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LDO05_02100"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_251377269.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.2e-31, bitscore:
                     106.2, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRIKVIRQLQPNECGLICTKMILDYYGCNIELRDIRNDIGSIRD
                     GVNIFQMKAYLQKYNYQAKVLKVNAENAADALKKVQLPSILFWEYKHFVVLEQIKNNKY
                     YVVDPELGRKTYSEDELLARFSNILLETGQLDNSIKVPKVKFKHKWQFFISSIKSSTNK
                     IIASLLLSVFMYVVTIFSAEYSKRLINSITGAMASGDIQGHLSTFSNFVMVFLLFLVIV
                     FAAAFVRELVSLSLRVDTEKKIVSEAFKKTLSLPYSFFESRTNGELLTSLGSVNLLKDF
                     LLDKYIKMFFDVGLFILLVGYVFSISMDLFLVHVILLIVNQVIIYSVSSRIKELSQQEF
                     SLNSMSNSIQIETLHSIQLTKVMRSENEIFAKWQDVFSQLQKIRKQKQFYQGIISSFTN
                     TMNIVIPLIVLLIGFFLVIYQKITLGDIVIAQTFTIMSISLLSQIVGTYSEYMVNASFI
                     ERINDIVLHPEEVNGTREIDKIKSIEVRNLNFSYTKDANLILKDINMTINRGEKIAIVG
                     LTGCGKSTLVKLLAGLYREKELPIYYNNVPLNEINTISLSEQVSSVLQDMHVYSDTIFE
                     NIRAQRFSYTEEDVIRAAKGACLDQDIAKFPMGYYTVPTDSGVDLSGGQRQRIAIARAI
                     LNNPTVLIFDEGTSYLDYTTEKQIMSNILGQDNIAIIVAHRLETIKSCDRIYLMEKGEI
                     VEEGTHEELLARKGKYYYLYSH"
     misc_feature    complement(15298..15315)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 18.45"
                     /tool="antismash"
     gene            15358..15537
                     /locus_tag="LDO05_RS02090"
                     /old_locus_tag="LDO05_02105"
     CDS             15358..15537
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038161.1"
                     /locus_tag="LDO05_RS02090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LDO05_02105"
                     /product="class II lanthipeptide, LchA2/BrtA2 family"
                     /protein_id="WP_251377270.1"
                     /transl_table=11
                     /translation="MTKREIRREVLANNTFICEKEERELQDKVGAAIPITTSSWICGVA
                     SAAFCPSTACTSKC"
     CDS_motif       15358..15450
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTKREIRREVLANNTFICEKEERELQDKVGA"
                     /locus_tag="LDO05_RS02090_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       15451..15537
                     /prepeptide="core"
                     /locus_tag="LDO05_RS02090_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-1.60"
                     /molecular_weight="2615.0"
                     /monoisotopic_mass="2613.3"
                     /core_sequence="AIPITTSSWICGVASAAFCPSTACTSKC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTKREIRREVLANNTFICEKEERELQDKVGA"
                     /leader_location="[15357:15450](+)"
                     /alternative_weights="2633.1"
                     /alternative_weights="2651.1"
                     /alternative_weights="2669.1"
                     /alternative_weights="2687.1"
                     /alternative_weights="2705.1"
     gene            15651..18497
                     /gene="lanM"
                     /locus_tag="LDO05_RS02095"
                     /old_locus_tag="LDO05_02110"
     CDS             15651..18497
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="LDO05_RS02095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LDO05_02110"
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_251377271.1"
                     /sec_met_domain="DUF4135 (E-value: 8.3e-89, bitscore:
                     296.1, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 5.9e-35, bitscore:
                     118.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMNSICSFPAIKNNDDLKISLKEYFSHNSKETGLSEEYFRNYYAP
                     FYSCLKRVIEEHFSGFTVVYPVQSTYLQVIMDEVIYKIREVSSNTLLTELNINRLSGVL
                     QGDTKEERYSFFDDEILGNEEGFFEILEEYPEMLSLIVLNFNQIAEQHYHILTSIINDY
                     TDLKNTFFQVDFVITGYKFGFGDSHNNGKSVVIVETNMGNLVYKPKTLYIEQHFNELLE
                     WINSKSSHLHQQLRYPKVICRQGYGWQEYMDNEELDGLESAHDFYYRQGMNIALMYILN
                     ANDFHYENLIAHGAYPVLVDIETFFSNIVPQEEEDELSRSYQTSVLSTMMLPMDFGEIL
                     DFEISGLSGKEGQVSSLYSSLKLVNNKSDEMQFVQQPFIVDGKSNIPVFEGQRIEAVNY
                     IEEICEGFSYCYNLIRNAKGEFVDAIHMFKDDTIRVVLRATQTYSEFLSMSRYPKYLVS
                     PDKRKELFNLLYEHQTDKFRLDIIHEEIRSLVNDDVPYFYTSIGSTTIRINEIQIPNYF
                     RISPLDSAKDKIIRLNDDDLKLQIKIIRLSLGFELSKTDADNKYVDTAKLLRISRDDKP
                     EIRHQIEYWAEDILNKSTRLPSGRIQWFSHVTDTGQKAKLGYMLYGLYDGITGMTILFG
                     LLSEFIDSEKYEPYYSLLLEDIMENEHKVLEHENNVCGFGNTGSIIYTYLYLGRLRNDT
                     ELISRAAGLAIQFSAKVVSIIEKQRAEIDFVSGISSLLVILCRVNKESASAELTESIGK
                     ITDYILLELETHKANEDYRTGFAHGYSGIVFALNLAASYTAVPDTKLEELILLENNKYD
                     RVSGKWSDTRKNDNIYSEDYWCQGSPGMYISRMELSRKLPAEMLMLDELRDRSLGSTRE
                     FTNYSLCHGYLGNLLIMDHAHHSAGDGFHLPRSGDEYVGGLGVHTESLGLYLGEAGLVY
                     FLITMLGYDVPKILYLEV"
     gene            18541..20670
                     /locus_tag="LDO05_RS02100"
                     /old_locus_tag="LDO05_02115"
     CDS             18541..20670
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="LDO05_RS02100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LDO05_02115"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_251377272.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.7e-36, bitscore:
                     121.6, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNRIRMVGQLHQTECGYCCLAMISGYHGLHVTLRELREIGNTGR
                     DGLSLLDIMEICDKLNLEARTYEIEATDTANFGLPCIAFWEEKHFVVIEKFDKKGVWIY
                     DPAGLDKVRISYEEFNEKFSNYIIEVNRTEQTEVRKRVNVWRPYLKYILDNKKFIVIFL
                     FSSIFLYGITLILSYFMQEIIDRLTNNTLSVNLVLISALLVVAFQTVIRLVQGKSVLYL
                     NNNVDFKFMDDFFSHLLKLPYHFFQSRSSGDILYSASSIRVIRNTLSTEVITSAMNLFF
                     MLFVLIYMFVFSEVIALLCCTLIIIYGLLLLVNTKYLTRFTNNEVMNTSKLHANQNEMI
                     FNIFSVKINGIEGLVYKEWKKKLENFIASVKRKENFSNYIQTSIGAFETLSPLLVIWLG
                     AYLYLQGMLTTGEIVMLYTLSIQLFTICKSLFQLYSSFVTSTMYLSRVHDVLAEEEEKA
                     NPNGVRPVLHGNIRLDNVSYKYGKGSVLSGITLQINAGEKVALVGESGSGKSTLAKIIV
                     GLYPPNSGNVYFDGYDSFDIDTKYLKSLIGIVPQEITLFNKTIRENIILHDVEVTEEEL
                     EKAAMKANIYEDIMDMPMKFNTLVSESGTNLSGGQKQRIAIARALINNPKFIVFDEATS
                     SLDYKNEKQIDEYLKEIECTRIIISHKLTSIKDADKIIVLKNGQIDACGNHEELIRNNE
                     FYRNYFNLLEYSPGR"
     gene            20872..21888
                     /locus_tag="LDO05_RS02105"
                     /old_locus_tag="LDO05_02120"
     CDS             20872..21888
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017689723.1"
                     /locus_tag="LDO05_RS02105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LDO05_02120"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_251377273.1"
                     /transl_table=11
                     /translation="MKGKVTVQEIADFVGVSKFAVSRALAGKSGVSEKTRDTILQAAAE
                     LGYFKNRPKRVTPAPAPEGGGSWKGNILVLFPNIRFQNRDSLYWGPIFDGVSARLNEKG
                     IDIITLTEPSTEDIFSLINPDAVSGVITVGTVSSSILTEIDRLKIPVVMIDHMDPVLKC
                     DTVFTDNFMSINEIMNYLLNKGYRDFQFVGYPGYAPSFRERWTAYRAFLEEKGIEGNQA
                     EGLISPAREELAQTIMDMKPRELPEVFLCANDIMASFTIEALTAKGIKVPGRCVVTGFD
                     NLNEELPLLATAEVNKEQLGMRAVDQILWRIQNPHHANERKMVSTEIIVHEENGMKH"
     misc_feature    complement(21936..21947)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.96"
                     /tool="antismash"
     gene            22115..24685
                     /locus_tag="LDO05_RS02110"
                     /old_locus_tag="LDO05_02125"
     CDS             22115..24685
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019913447.1"
                     /locus_tag="LDO05_RS02110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LDO05_02125"
                     /product="glycoside hydrolase family 2 protein"
                     /protein_id="WP_251377274.1"
                     /transl_table=11
                     /translation="MIQQLNNWTFRACDEQQWRSAVVPGCVHTDLLRNGLIPDPFYGTN
                     EHDLQWIDKKDWEYQSEFEAGPELLGLTRIDLVFEGLDTYADVYLNEQPILAADNMFRI
                     WKVDVKEQLKPGLNQLRIRFRSPIHEDLPKLEKLGYALPAPNDQSELGGLENKRVSIFA
                     RKAPYHYGWDWGPRFVTSGIWREVRLEGWSQLQITDLYIRQDEVTAEAAKLTAVAEVNA
                     EANWAGTLRITAGGKQWEQPVQITAGQSTVSADVELASPDLWWCQGLGEAHMYTFQAEL
                     LFEEEELAKKSVRTGLRDLKLIRERDEAGVSFYFQLNGVPVYVKGANHIPNDSFTAEVT
                     RERYLHEIVTAVESNMNMLRVWGGGIYEEDVFYELCDEYGLLVWQDFMFACSMYPGDEA
                     FLNSVRAEAVDNVKRLRNHPSLALWCGNNEIDSAWAHYVEDAGWGWKKDYSPEMREKLW
                     ADYEAIFHKLLPEVVSELSGNIAYWPSSPLRNLTGDQEQHAHKTTGDGDIHYWGVWHAI
                     EPFENYNKNVGRFMSEYGFQSFPELKSVLEYAPEEALELESEIMLAHQKNGRGNLLIKE
                     YMDMYLPEPKNFKSFLYMSQVLQAEAITMAIEAHRRSKPYCMGTLYWQMNDCWPVASWA
                     GMDYQGRWKALQYAVKRSFAPVVVIVQSVGDDINFYAVSDLGTVIQAELVTELRKLSGE
                     LILQKVHSVALGAGESTEVFHITRNELLGGLDSHDVILTAVLKQGGDVIAAREHYLAPE
                     KELKLVKPNIKLTEATDESGGTVYTLETDTLARQVWLSTPEEGIFSDNFFDLVPGQPRT
                     VEFKLRSGEGSFVPAAASRLDIKSMADFVGEASLVQLSEIKASK"
     misc_feature    24832..24850
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 23.3"
                     /tool="antismash"
     gene            24953..26344
                     /locus_tag="LDO05_RS02115"
                     /old_locus_tag="LDO05_02130"
     CDS             24953..26344
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1212:
                     sodium:dicarboxylate symporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009223940.1"
                     /locus_tag="LDO05_RS02115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LDO05_02130"
                     /product="L-cystine transporter"
                     /protein_id="WP_251377275.1"
                     /transl_table=11
                     /translation="MTTFWVILNVVVMLVLVGFLLWLQKKHVSFTKRVFAGLGLGIVFG
                     VILQLVSKPDSEVVAKSTDWFNLIGYGYVGLLQMIVVPLIMVSIISAIMNLKGKQNLGK
                     ISASIIAVLLITTAIAASVSIVTSLSFNLKAIEIQSGDKEQQQGAKLEERLGDVKDLTI
                     PQQILEFIPTNPFEDMTGARRSSTLAVVIFSAFIGIAVLGLDKKKPEQADTFRKIVDAV
                     YAVVMRIVTLVLRLTPYGILALMAKTIATTNADSIVKLIKFVGASYVALIIMFIIHLIL
                     LALFGYNPVRYVRKVLPTLVFAFTSRSSAATIPLNVETQTKKLGVPTGIANLAASFGAT
                     IGQNGCAGIYPAMLAVMIAPTVGIDPLSWDFILTLILVVTISSFGVAGVGGGATFASLI
                     VLSTMNLPVALAGLLISVEPLIDMGRTALNVNDSITAGVITGKILGENDKEVFDKDVDL
                     DVATA"
     gene            complement(26505..27650)
                     /locus_tag="LDO05_RS02120"
                     /old_locus_tag="LDO05_02135"
     CDS             complement(26505..27650)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013915082.1"
                     /locus_tag="LDO05_RS02120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LDO05_02135"
                     /product="winged helix DNA-binding domain-containing
                     protein"
                     /protein_id="WP_251377276.1"
                     /transl_table=11
                     /translation="MSSDNTAPEAISGKEELPVLSTRALNRALLARQMLLCREELPSLE
                     AIERLAGLQAQSPSAPYFALWARLETFNPEELSHLLQEKKAVRIALMRSTIHLVSAGDC
                     LSFRPNLQPVLDRSLQGAFGKALTGLNLNELASRGRDLVEETPLTAQQLGQSLQVIYPG
                     YEPSALSAAVRNSVPLVQLPPRGLWGKSGQAVHTSAEKWLGQPLSPVSSADQMVVRYLA
                     AFGPASVKDIQVWSGLTRLSEAVERLRPQLITFRDEHGSELFDLPGAPRPDPSTPAPPR
                     FLGEFDNMLLSYADRTRIIDKNIQPRVCTKNGLVRPTLLLGGFVCGTWTLKRERGRAVL
                     LIEPFKPLTIQEKEALTEEGARLLHFAAASAKSHDIRFEDI"
     misc_feature    complement(28246..28261)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
ORIGIN
        1 cctatgagga gcctctgttc gaacggggag acctgctcgc ttcgacgcag aaggagaaga
       61 tgcaggagcc gtttattttc caattcgtat ttaaggatga atccaagccg ccgctgacgc
      121 tggtgttctt cgatgtggcg ggcgagggca tggtggatca ggattacctc ggtctgcacg
      181 gccagcatat caagaattcc gccggtattc tgttcatggt cgatcctctg cagatccgct
      241 cgatccgcga gaagatccgc atcaagcatg gcgacaagcc gggcgagtgg gtgtcgcagt
      301 atgacgaacc tcgcgatgtg gtgctgacct tgttcgggga tttcatcgcg tacgaggata
      361 aagggaagac cgatattcca acagcagtcg tgctgacaaa aagtgatatg ctgcatgcgc
      421 tggcggatga ggaaggcgag tacatcaaga agaacagcaa tattttcaac aatgctgtcc
      481 accgccggac gctgaatttg acggagttcg agaatattga cggcgaggtc cgccacttga
      541 tcgagaaggt ggatcgtccg ttcaaaggca cgatggatgt gtactttaag gataccgctt
      601 atttcgcggt ctcggctctt ggaagcaatc cggtcgatca gaagctgcag ggcgtcgtga
      661 gcccgatccg ggtcgatgag ccgttcatct ggctgctgta caagctgaat tacatcgagg
      721 ggagtgaagc gtagtgaatc ccttcgctcc gatccagcag cagatctata cccgcgcacg
      781 gcacgggatc ttccgccaga ccgaagggtt cgatacggtg gcaagatctg agggccttga
      841 ggcttctttt atcaaaaaag tgctgcatcc gttctgcgtc tacgatgcgc ccgcagagct
      901 tgccgcgcgc ggtgagaagg ataacttggc ttatcccggc gccattcacc tgttccacgc
      961 ggagaacggg gatacggtgc tgggccgcag catctatcaa gctgctgatt tcacggggct
     1021 gcgcagcgcc ttattcagtc acaactatgt tattccttcc tcaaggtcag aggagctggt
     1081 ccagaactac cggtcttatc ttcatgctga tttcttggat cattatgata ttgggcagag
     1141 cgggcagatt cctgaactca accagatccc tgtagaccag gcgtcactag gcagcgacag
     1201 ggtgaaaccc gcgcagctgc ttggggagct gcatatcccg gaggccatgt tcaagcagct
     1261 gctggccgcc gtaatgactt ccgtggctgg gggacgcaag gtctatatcg cactggatgt
     1321 ccctgcttct tacatatcgg aagcggcggt tcccttgcta gagctgctgt atgctgccct
     1381 gccatatgct taccgcagga agctcggctt ccttacctat gccaaggaac cgcagagccg
     1441 gaagggcatt catatctctt tcgttgaacg cggcagtctg cgtcatgggg accgcagcat
     1501 cgagaaggac tatacgttcg atctcgcctc cgggcgggtg accaatatgg agctggactg
     1561 gacgaagcag ccgtatcttg atctggtctg gtcgcggatt ggaagtctgg atcacctgga
     1621 ggacttccac cggttcgcgg atattatgct gaaggatatg ggccctgaga agccgatgtc
     1681 gatctccagc tatcatgagc ttagtgtgct gtaccggatt gagggaggcg atgaagccct
     1741 ctatgagagg cataagattg ccgctctcag cgggatgctg gaatatcttc gcccagcggg
     1801 ggccctaccg gtcaaggagc gcctgagtga tctgttcctg gctcgctttg acagggagtt
     1861 cgatattgtg aaatcgggca aggttcctga tcttgcagtg gcggaatgta ttaaggatta
     1921 ttaccggatc gacccgaaga acaatgaacg gaagatcgtg gagtatttca tccgggctgc
     1981 tgtcaacgcc attaaggata aggccgcatt tgcggggctc tatgccttaa tcgagaatca
     2041 tccatctctg cgcaaagcct atttcgatca ggtgcagaag gatgatcagc tctcagcgct
     2101 tcttctcgtt ccttatatcc agggaagact gcaggctgct gaaaagcccc gcgaagtggt
     2161 cagtctcgtg caggaatggg atcggctctc ccccggaatg tgggataagt tcgcgctaag
     2221 tgagctcgcc cggtcggggc tgaccggcaa gctgaaggta cagcaagatc tggttgcgtc
     2281 ggtaaatgag gtgcttcata tgctcggcgc acacccgggt ccggctcaag agaagggcca
     2341 gtacggagag tgggaagagc agaagagaca gctgaagatg aggcagcaag gagaagcgga
     2401 tggggctccg ggaagacaag agaatgactc ttggagtatg ctgtccaagc cagcgcgggg
     2461 gcaggtcatg gatgaatttg aatccaagga tgccacgggc caattcggcc gggaaggctc
     2521 cgggatctcg gctgttctcg ctgagacggc ccggcgtgtg ctgctgatag agctggatct
     2581 gaataagctt accaaggagg agctcttaag cctggattgg ttgaagagcg ctaatccagc
     2641 ttgcggcccc cagcgcctcg atgggcagct gaggtccaag ctggctaagc tgcaatcctt
     2701 atatgcctgg ttcagcgagg ctgaaccaga tgtgcatgtg ttcgatggac taaagcccgc
     2761 cgagatggat gaagttcaga aagccggccg cagatggcta agggacgaag tgaacgcaga
     2821 ccggttcgac cggcttacct tggcatacta ccggggagga gccgaggatt gcatggatta
     2881 tgcccccctg gtagacgcgc ttcgcaaata tgcggggagc ccggatatag tgtaccgctt
     2941 cttccactgg tcggcagggc agcccttata tgtgcgggga agcaagcttg caccagctta
     3001 tgaagccgcc atactggcgt atttccgcaa gtatgaccgg gatgcgttca agaagcgggc
     3061 gaaccggaag gagcacttcg ataaggcagg ccgggcgctg aggccggtat atgagcgggc
     3121 gggacaggag cttgcttctc cgctgatgag aatgttcggc agaggcggaa aaccaatgct
     3181 gttcagtgtg ttcatcctgc tgctgcttgc cgcaggaacg ctgggtatac tccagctgac
     3241 aggggccttc gataagaagg agcctgcggc tgtagttcct ccggtcgtgg acaagcctga
     3301 tgttacggag ccggcaccta gtgtatccat accagaccgg gcggtctata ccgaacaggt
     3361 caaagacaaa agcggcaagg aagttacaag gctggtcttc ttattcagga ctagctcgga
     3421 gtgcaaatcc ttcaatccgg gttcagtcac tgtaaccacc ccaggagcta aggcgacaag
     3481 tcagaacttg aagctctcca atctggccca cgattgcggc actggggatt ctgaggagac
     3541 aggcgtgagc gctgccgggt caacagatag cggccactcc tccggtctgg agtccgggaa
     3601 taagaagtca gcaggagcgg aggaaggctc agttagcagc gagaatgacc gcttagcgca
     3661 aagttcggtt gacggccagg atgacaacga ggctggtctt tcagttgacg gtgagggatc
     3721 gtccacacag acaggtacac agaacgcagg tgtttcttca ggggagagtt cctctagttc
     3781 ttctattgac ccggacgttt accctaataa gctgacggca gcacttggca aggcatacag
     3841 tattccggaa ggcagcagga ttagcgcggc cggtctggag tttgtacgaa tcagcaagac
     3901 tgcggctggt aaggagcaat aatcgtagca gtgttaaagg tataaattca tacagactta
     3961 gtagctcagc tgttgctgca atctatgctg gtttgtcaat gcatcttgta atccgttcaa
     4021 ataataaatt acacgaagga gaccgtttat tgtgaacggt ctccttcgtg taatttatac
     4081 taaaagaata atgggaatgt aagaatgaat aataagctta aaattaaaga aacaatcgcc
     4141 caaatatttt tagtttgcat attcctgctt cttacaaaca aaaatgatga tatcaaaaac
     4201 gctgctatcc aataatacat aagaataact ccaaatccgg gaaagtcgat aactttataa
     4261 tgtactgaaa tcccagctat aacagaaact agtgacagaa taattagaac tttttcaata
     4321 ataaaagatt tatttctcaa aaaatcaccc tcatttttaa tccattttta aaataatctg
     4381 ctcttgcagc cttggtttgt agcttatgaa actagtttct tttcagtcat agcttatttt
     4441 acgtactgaa aaaactgtct tctgaattaa gatgggaatt atggtttaag caatttaatc
     4501 ttaataaatc taaacaaaaa attgataaga atcggaagag aaagaaaaac taaaaccaaa
     4561 acaaatattt caacatccca cgccttaatt gtacccgaaa aaattacata gcctattgct
     4621 ccataaatcg aaactctcac gatcaaccct aacaaatttc tcattgaata taagaagctg
     4681 gtaacaacca caacaattaa aaagtcctgt atattattat tcaataaaaa acctcccttc
     4741 agaacgatcc tataacttac cttatcccta attgtaacag tatttgctaa ataatcccat
     4801 ataatataaa aagttgttgt gcctcaagtc cggtacagca ggtatacaag ataggtcttc
     4861 ttgatgaaac gggtcttttt ttaatcacca taccattgtt cgtgtttaaa ggattagaaa
     4921 ttataatttg cctctgtcta ataaggtggc tgtattaaat gcgaacatta tccgacttgt
     4981 gtattgacac attcgtattt gttgtttatg cttctacatg tcatctgact ttgttggcac
     5041 ttacaacttc acaatttaac cattcgtata tcctcaataa tatgggttga gggtttctac
     5101 aagggaccat aaattcctgg ctacgaacag ggtgccgctg catacctatt cgcatatata
     5161 tcatgaatta cagagcttga tgcccagtag ttcaagacta tagccaggat tttttgcgtc
     5221 ttaaccaaga gactacacta aaccgtttat tttaggagga accatgagta aatatgatgt
     5281 aattgtcgta ggtgctggtc cggcaggaat attcgcatgt tatgaactga gcctcaaggc
     5341 ccctcattgg aaggtgctgc tcgtcgacaa gggtcatgat atctataagc gccgctgtcc
     5401 gattctcgaa gagaaaatca agctgtgtcc gccggctgcg ggcaagaagg aattcgcagg
     5461 ctgtctgccc gcttgttcca taaccgcagg cttcggggga gcaggcgcct atagcgatgg
     5521 aaagttcaac ataaccactg agttcggcgg ctggatgacc gattatattt ctccctccaa
     5581 agtacttgaa ctgattaaat atgtagatgc cattaatctg gggcacggcg caacaacgaa
     5641 cgtgaccgat ccaatgacgg atgtaatccg ggggattgag cagcgcggtt atgcggctgg
     5701 actcaagctg ctgcgggccc aggtcagaca tctgggtaca gagcagaatc tggagattct
     5761 gaagtccatc tatgagtatc tgagaacacg aattgatatg tccttcaaga cagaagttga
     5821 agatatcatt acgaccaagg atgaagcggg cgggctgcgc attggcggca ttacgcttag
     5881 aagcggcgag gtgcacgaag ccgacctggt catgatcgct ccgggccggg atggatcagc
     5941 ctggctcacc gagatcctga aaagacgccg tctcaaaatg tacaataatc aagtcgatgt
     6001 gggcgttcgt gtagagacct ctgacgtggt tatgagggag attaacgagc acttgtatga
     6061 aggcaaattc atctacaaca cctcggtggg tacccgggtt cggacgttct gcagcaatcc
     6121 ttcaggtcat gtcgtggtcg agaaccacag cggcgtgatg gctgccaatg gacattctta
     6181 caaggacccc gcgctgggtt cagcaaatac caacttcgca ctgcttgtct cacataaatt
     6241 cacggagccc ttcgacaaac cgaatgaata cgcgcgggaa atctgccagc gtgcgaatga
     6301 tctgtcgaac gggggcgtta ttgtacagaa gtatggggac attattcgcg ggcgccgctc
     6361 aacggagagt cgaatctcgg aaggctttct ggagccaacc ttgaaagagg cggtaccagg
     6421 tgatcttggc cttgtgctgc cgtataatac aatgaagagc ctgattgaaa tggtcgaagc
     6481 cctggacaag gtgactcccg gcattgcttc ggagcatacg ctgttctacg gcgtggaagc
     6541 caagttctat tctgcccgtc cgaagctgga tgcggcactg gagaccgaga ttaaaggtct
     6601 gtactgcggt ggggacggtg cgggaattac ccgcggattg gctcaggcag gagccgcagg
     6661 ggtctggatc gcaagaggca tgatggagaa ggccggaata tagattgagc taaatagcat
     6721 ctagaatgtg agaaagcact gccatacagc tgcgtgatgc agctgggcgg tgcttttttt
     6781 ctaataaatt tttgctgagt acatacttat agagggggat aatatggctt gcctgagaga
     6841 tcattttaac gagaataagt acctggactt tcaaattgtc aattgcagta aatcaataga
     6901 tcagggaagt agtctccgtg tgaaaataat tgatccagat caagacagca atattacagt
     6961 cgatttcggt tggactaacg aaacctaagt aagtttctta cgatgttgga gaaattcccc
     7021 ttagaaattt atagtggcta tttttctcat tatgatgagt cctttgagtg gaagtggttc
     7081 catgaacaag agactggatt atatctaatt gttatttttc tatcaggctg gattcctaca
     7141 ttgaaggtta gcaaagaaga tttaatcaat ttcggtgctc atatactcaa agagtttgaa
     7201 tctgcacctg aatattcaaa ttagcaagtg taatgtcatg gttctgaatt ttcacatacg
     7261 ttagatcgct aatgacgagg ttccgattgc tcaagctctc gatccagaac atttgtcgtc
     7321 caccataatg agtcaagttc aaagtgccca gtctataagt accagtgtta aaaatgaaag
     7381 aagtactcag ctttctgcca atcgatttaa aagaatggtc aaaagcagag acttggggtc
     7441 tgcttcaaaa gagtcccggc tcaatcccaa tcagcgaatc tatttgtacc cctccggata
     7501 ttttgtagct gttgtaaggc tgtcgatgcg cccattcttt tcccgggaaa tatcgacaaa
     7561 cttccttaga atctctcgtt cgttctcctt atcctcattg ccgccaatga tcttacggat
     7621 aggagatcgg ctctttcggt gctgcacaac agaaaaagag ccttgaaccc gtatgaatag
     7681 tggattcaag gctttcgaag aagcagtagg ttcctcaata actaagatgg caatatggtt
     7741 catatttcct ttttattaaa aatagacaga ccgatcacaa atgcggccac gaagtacaca
     7801 agtgcttcca accagttgaa taacagattc tccattgtga aaggcagacc ttccgagagc
     7861 cggattaccg ggaagatatg aagaagagac ttcagtcctg ggatgatatt ctcgaaattc
     7921 cccaaaaaaa ccgggattat gtatatgatc aagaagtatt tgaccaggtt ggagacaatc
     7981 ttctcttctg taaagcacag cataatagat atagagtaag cggcaataaa cagaggcatg
     8041 gtctggatta tattttgata aaataaggtc ttctcgccta ggtccttatg gttaagaagc
     8101 agttcaatcg ctgacacaat catagctatg tcaatcacgc tgagcagcac taggatacag
     8161 aagatgaccg tgatttttga caggtaaata tgtctcctgc taattcctga agccacaaca
     8221 ttcttgaatg taccactcga atactcgctc gcaaaaagat aaatcgttag aaagggcagc
     8281 aggagcacta gattattaaa agaaatccgg cagaacctgt ataagaaacc cgtgctgttg
     8341 taagtaaagg atgggtcgga cctcccaaca gaccagacca gaaagatacc gagcaagggg
     8401 attgccgcta gtaaaaaggg cagcaggtag atcagctttt tggacttgat tctatacagt
     8461 tcgcttctca gataattgtt catgttctgc acctcccacc aactgaaaga agtaatcctc
     8521 aagtgaatca tggctttcat ggacagagtg gattttctcg ccggcatcca ggatcagctt
     8581 ggtgatgtcg gaaatctcta gatggtcacc ggacagctga atctcggaat tatccagaag
     8641 gcggatctca cagttgttca gatgattcct tagaagaaga tgaatcttgt cataattaga
     8701 tacttttagg cgtacggatc gtgtgcattt agttcttagc tcgtccattg tcagttcctg
     8761 gattaacttg ccattatcga tgaatccaac cttgcttatg acctgttcaa gctcagagag
     8821 aatgtgactg gagataacaa tcgtgatatt gtgctcccgg ttaatgctta gcagcagcct
     8881 gcggatttcc ttgatgccga tcgggtctaa tccgttggtg ggttcatcca gaatcaatat
     8941 tctcggattg tccaacaagg caagggctat ccccagccgc tgcttattcc ctaatgaata
     9001 ctgtttgaat ttcctgtctg ccagagggac taaattcagg tcattaagta ccttctccac
     9061 agcgcccttc tgtgaaattc ccctttgaat ccggtaatat tcaagattct gcctcccggt
     9121 tagctcagga tagaaggctg ggtattctat cagcgcaccg attctcttgc gctcattgga
     9181 atcctgcttg acggtgtgtc cgaacagctt cacgctcccg gagtagcgtg tggattgtcc
     9241 gcatagaatt cgcagcaggg aggacttccc ggccccgttc tttccaatca gaccatagat
     9301 ctctccctct tgaatgtgta gattgacatg atccagagcc ataatactgc ggtattgttt
     9361 ggtcaaattc tcaacctcaa ttactgcacg cacagaatct cctcctgaat gtaaaatgaa
     9421 tgcgcgaacg agttcaataa agatcataaa ttcacattaa atttacagat ttcaattcga
     9481 atttataaac tttatcaatt aaggaagcaa gctagcaatc cagtatttac aactacttcc
     9541 atgcagagtg taatttataa ttataaaaaa gtaaaatatg attatacaaa aaggtgactt
     9601 taagcgcatt ttttcatttt taaggataaa tctactaatt taaacaaaat aatggttgcc
     9661 aattaataat aaaaatctat aataaaaatc agctgggtat atatcccata actaggagga
     9721 ataaaaatgt tagagaatag aaacccattc atcgttttta accaagaggc aaaaatggaa
     9781 gcgttatctc cggtactggc agaagaactt atcgaagttg atctgagtat tcaaggcgga
     9841 tgcacaacga acacctttac gttgagtaac tatctgggca acaatggcgg ctggtgtaca
     9901 ctgacgaagg aatgccaacg ttcctgtaac taatccaatc taaaaaccga atgtacccag
     9961 ctaccctatt attacttact taatgtcagg aggagagact gtgaagttaa gtaaagagga
    10021 agtgctccct ttttggaaat cattattagg aattcaaagc gaagagaagc tagagtcaca
    10081 cctggagagc ttttttggag aaccgatcga tatccaagtc gataatatta acaaagagaa
    10141 cgaaatgaag gcattgggga ttagtagaat acaagagagc agcaggaaac agaacttctt
    10201 cgcaaaggaa ctggattact tctcgctcaa gctgacagaa cttgtagaag ccagtgcggt
    10261 catagaggac aaagagcatt tcatcgattc ccaaaaagag cagttggaga agattctcga
    10321 gaacgatttg tggtatttcc tgattgatga ggctactctt tattttaacg ataaaaaaga
    10381 cagcatcaaa aataaaaacg gggaagaaat gctcaagatc ttcatcgaag aagtctttca
    10441 tacagagcgg ttcagaagcc agtgtgaagt gctgtattta gagctgttcc cgctaatctc
    10501 attacgtatt aacaactatc tttcttacgt cgaggagatt ataagcaacg ttacgataga
    10561 cctgcacaat atagaggggt tgctgccgtc cgcccattcc ccgctgcagc tgaatgatgt
    10621 caagcttgga agcggagata cccactcgga tgggaaaagc gtaggcaagt tgatctttaa
    10681 ccggggtgtc gtctattaca agccaagaac gggcgagctc gatatcaaat tttttgactt
    10741 cctggacaag ctgtacctgc aggacgagaa gttcgatttc aagaggatca agattattag
    10801 cagagataca tattcttttt ttgaacagat agatcatgtt ctggttaggg attcaggtga
    10861 gctggagcaa tattatgaga agctgggcta tctactgtgt attatgtaca cactcaatgg
    10921 cacggatttt cacagtgaga atattattgc ccatgggaag gacccggtat tggttgacct
    10981 ggaatcatta tttcactcca atatcttctt gaacgagaat ctctatgatc aagggttcct
    11041 tgagattatt aaatcctctg atccgaccgt gctcgacatt ggaattctgc ctaagaaaat
    11101 agtcaagaac tatgattcag atgactattc actcgagatt ggcggcattg gcgcagagaa
    11161 acagaaggtt tcacctttta aattctcgga attcagcatt gatgaccaag gacaaccgcg
    11221 gcatatcagg aagttcgggt tcaatggagt aagtgagaat aacccaatta aggaaattag
    11281 tgattcagag ctatccgcaa tcaatctgat tatgcagaat agttttgaat atttttataa
    11341 atggattttg aacaataaat ccctgtatat cagcatggtt aacgatcatt tcaaaagcaa
    11401 aaaaatacgg gtgatcttaa gacctacctt cttatactcg aagctcatga tactgagtaa
    11461 aaacatttat ttccttggca acagaacaaa ccggaagatt ctattcagca aattagctta
    11521 tgaaagagag aatcagatgt cattcgtgta cagcgaatat gaccagttaa tgaactatga
    11581 catccctata ttctatgcgt ataccgatga actggagatc tataatgcgc gtaacgacaa
    11641 gctgggagct ctatcggaca aaactccgct ggaaagtaca attctgaaga tcgagaagat
    11701 gtcgccagat gacctggaca accagaagat cttgattgac caggccatga ggctcaaaga
    11761 atataaaggg gaccggacgg atattaagtt cgcgcctgct gcggctgctg ttgatgagat
    11821 tgattccgaa agggcacatc agctctgtga gaatatcggt aatctattga tgaggcgggc
    11881 ggtgtatcct aacgatgaat cgattacctg gatcagcacc acgatactcg ggaaggaaga
    11941 atccgaattt ggcgtaggtc cggtcggtaa tgatatgtat ctcgggaatg cggggatcac
    12001 gctgtttcta gcccatctct ataaatttac caagaatgag aagtataaag agactgttct
    12061 taaggcagtt cattataata tccggtttct gcagcaggag aaattatacg agaacggaaa
    12121 tatcggctat tacaacggaa ctagtggact gttactaagt attggcgtga ttaacaccat
    12181 cattccaatt cctaacttcc attctattat gatcacatct ctggaaagat taatgaagct
    12241 ggtgaagaac tgcaacaact acgatatatt cgcaggctcc agcggattaa ttacaagtct
    12301 gattgcgctg gacaagttgt atccggagta ccgggcttat atccggcctc tattggaaga
    12361 ggcatataga aatctgctcg gcaatgcagt tcgcgagaac aatatgtgtt actggaagaa
    12421 taagaatacc ttggcctatg taggctatgc gcacgggaat gccgggatac tcgcagccct
    12481 tattaagctg caggcagtgg aacaagagat tttgggatat caattggtag atagtcaatt
    12541 cctgttagaa atctcgaact atattgattc cgcctataat gaacaagcga acaactggga
    12601 gaacatcccc ggctccaaga aatactcgca tggctggtgc catggggctc aagggctgtt
    12661 gctggcccaa gttattgcca aagagaatca ctcggcaagt ctgagagatg aagattatat
    12721 tagcaacctg gtcgagatca cgatgcaaca tggcttcgga gctaatcctt cctattgtca
    12781 tggcgatttg ggaagcttga agattattga gaaatatgcg caggtgttcg ggaaggaaga
    12841 tctgctcaag caatgcttac agacctatgc aagtattttc tacaatacca ttgagaagaa
    12901 gtgggagaag caggttcttt cccactcgga atcattaggc ttattaatcg gtgtttcggg
    12961 ctggggatat tcagttctgc aatatttgta tccggatcag gtgttcgact tctttactct
    13021 gtaaggaaat taagcaccgg tctaatagaa acctttcatg gagcacctcc agagcggtat
    13081 agatgagaaa aattaacttc ataggaggtg cccggtgaag aggattaaag ttattcggca
    13141 gctgcagccc aatgaatgcg ggctcatctg taccaaaatg attttggact attacggctg
    13201 taatatcgag cttagagata ttcgtaatga tattggctcc ataagagacg gagtcaatat
    13261 ctttcagatg aaggcatacc tgcagaaata taattaccag gcgaaggttc tgaaagtaaa
    13321 tgcggagaat gcagctgacg ctctgaagaa ggtgcagctc ccgtccattc ttttctggga
    13381 atacaagcat ttcgtagtgc tcgagcagat caagaataac aagtactatg tcgtagatcc
    13441 ggaactgggc aggaagacgt actcggaaga tgaactgctg gcaaggttct cgaacatttt
    13501 gttagagaca gggcaattgg ataattcaat caaggtgccc aaagttaagt tcaagcacaa
    13561 atggcagttc ttcatctctt ccataaaatc gtcgaccaac aaaattatag caagcttgct
    13621 cttatccgta tttatgtatg tagttactat attttctgct gaatattcga agagactaat
    13681 caatagcata acgggtgcca tggcctcggg ggatatacaa ggacacttga gtacattcag
    13741 caattttgtg atggttttct tgttatttct agttattgta tttgcggcag cctttgtccg
    13801 ggagcttgta tcgttatctc ttagagtgga tacggagaag aagattgtat ctgaggcatt
    13861 caagaagacg ctcagcctgc cgtattcttt ctttgagtcc cgtacgaacg gcgagttatt
    13921 gaccagcttg ggtagtgtga acttgttaaa agacttttta ttagataaat atatcaaaat
    13981 gttctttgat gtcggcttat ttattctgtt ggtcggctat gtattctcca tatctatgga
    14041 tctattcttg gtgcatgtta ttctgctgat tgtgaatcaa gtgattatat acagtgtatc
    14101 gagcaggatc aaagagctga gtcagcagga gttctcgctg aactccatgt ctaacagcat
    14161 tcaaatcgag acgctgcatt ccattcagct aactaaagtt atgcgttctg agaatgagat
    14221 ctttgcaaag tggcaggatg tattctctca attgcaaaaa atcaggaagc aaaagcagtt
    14281 ctatcagggg atcatctcct cgttcacgaa caccatgaat attgttattc cgttgattgt
    14341 gctcttgatc ggcttcttcc tggtcatcta tcagaagatc acgttgggcg atattgttat
    14401 agcccagacc ttcacgatta tgtccatctc cttactaagt caaattgttg gtacttatag
    14461 tgagtatatg gttaacgcca gcttcattga gcgaatcaac gatattgtat tacatccgga
    14521 agaggtcaac gggacccggg aaattgacaa gatcaagtca atcgaagtga ggaatctgaa
    14581 tttctcctat accaaggatg cgaatctgat tctcaaagat attaatatga ccataaaccg
    14641 cggggagaaa atagcgattg taggcttaac gggctgcgga aaaagcacgc tggtgaagct
    14701 gttggcagga ctgtacagag agaaggagct gcctatttac tacaataatg tcccccttaa
    14761 tgagattaat acaatttctc tgagtgaaca ggtatccagc gtgcttcagg atatgcatgt
    14821 gtactcggat acaatttttg aaaatatacg cgcacaacga ttctcttata cagaggaaga
    14881 tgtcatcagg gcagcaaaag gtgcctgtct cgatcaagat atcgccaaat tccctatggg
    14941 atattatacg gtgcctaccg attccggcgt agatctatca ggcggacaac ggcagcgaat
    15001 cgcgatagcc cgggcgatac ttaataatcc tacagtatta atctttgatg agggtacaag
    15061 ctatctcgat tacactacgg agaaacaaat tatgagcaat attctcggtc aagataacat
    15121 tgccatcatt gtggctcacc gtctggagac cataaagagc tgtgaccgca tctatctgat
    15181 ggaaaaggga gaaattgtag aagaaggaac acatgaagag ttactggccc ggaaggggaa
    15241 gtattactat ctatattcac attagaagac tcatatgaac ctaacaaggg tacgactttg
    15301 acacaaagtt aacatataag aaccaaaaaa aataacatga cgaagggatg attaattatg
    15361 acaaaaagag aaatcagaag agaagttttg gcaaataaca cttttatctg cgagaaggaa
    15421 gaaagagaac ttcaagataa agtaggggca gcaatcccga ttacaacttc ttcttggatc
    15481 tgtggtgtgg cttccgccgc attctgtcca tcaacagctt gcacaagcaa gtgctagggt
    15541 agggactact taagttatag agtcataggc aggttagtca aagtcgtacc aactttacca
    15601 atttgcctgg cttaaattcg attcaacact tctgagataa aggggctaat atgatgaaca
    15661 gtatttgttc ttttccggcg attaagaata atgacgatct gaaaatttct cttaaagaat
    15721 attttagcca taattcgaag gaaactggac tatcagaaga gtactttcgt aattattatg
    15781 ccccctttta ttcttgtctg aagcgggtta tcgaggagca tttcagcggt tttacagttg
    15841 tatatccggt acagtctact tatcttcaag taattatgga tgaggtaatt tacaagatta
    15901 gagaagtgtc ctccaacacc ttattaacag agctgaatat caacagactt agtggtgtgt
    15961 tacagggaga tacgaaggaa gagaggtatt ccttcttcga tgacgagatt ttgggtaatg
    16021 aagagggttt ctttgaaata ttggaagaat accccgagat gctgtcactc atcgtattga
    16081 actttaacca gatcgcagag cagcattacc atattctaac ttctattatt aacgattaca
    16141 cggatttgaa gaacacattt ttccaggtag actttgttat taccgggtat aagttcggat
    16201 tcggagattc acataacaac ggaaaaagtg tagttatcgt tgaaactaac atgggaaatt
    16261 tagtgtacaa gcccaaaaca ctttatatag agcagcattt caatgaactg ctggaatgga
    16321 tcaattccaa gagcagccat ctccatcagc agctaaggta ccctaaggtg atatgcaggc
    16381 aagggtacgg ctggcaggaa tatatggaca atgaagagtt agacggtctt gagtccgctc
    16441 atgatttcta ttatagacaa gggatgaata tcgccctgat gtacatattg aacgccaatg
    16501 acttccacta cgagaatctg attgcccatg gggcctatcc cgtgttagtg gatattgaga
    16561 ccttcttctc caatatcgtg cctcaagaag aagaggatga gctttcgaga tcttatcaga
    16621 catccgtcct gtccaccatg atgctcccga tggattttgg agaaatactg gatttcgaga
    16681 ttagcggctt atccgggaaa gaagggcagg tatcctctct atattcctcg ttgaagctgg
    16741 tgaacaataa gagtgatgag atgcagtttg tccaacagcc ctttattgta gatggcaaaa
    16801 gcaacattcc agtcttcgag ggacagagga tagaagcggt caactacatt gaggagattt
    16861 gtgaaggatt ctcgtattgt tacaatctca tccgcaatgc caagggtgaa tttgtggatg
    16921 ctattcatat gttcaaagat gacacgataa gagtggttct acgggcaacg cagacctatt
    16981 ccgaattcct tagtatgtcc aggtatccta aatacttggt aagtccggat aaaagaaaag
    17041 aattatttaa cctgttatat gaacatcaga cggacaagtt ccggttggat atcattcatg
    17101 aggagatcag aagtcttgtc aatgacgatg tcccatactt ctataccagc attggcagta
    17161 ctactattag gattaacgag attcagatcc ctaattactt ccgtatttct ccactggata
    17221 gtgcaaagga taaaatcatt cgcctgaatg acgatgactt gaagctgcaa attaaaatta
    17281 taagactgtc cttaggcttt gaattgtcca agacagatgc ggataacaaa tatgtggata
    17341 cagctaaatt actgaggatt agcagggatg acaagccgga aatccgacac cagatcgagt
    17401 attgggcaga agatatcctg aataaatcaa ccaggctgcc aagtggccgg atccagtggt
    17461 tctcacacgt tacagatacc ggacaaaagg caaagctagg ttatatgctg tacggcttat
    17521 atgacgggat tacaggcatg acgattctat tcggcctgct gtcagaattt atcgattcag
    17581 agaaatacga gccttattat tctctcctcc ttgaagacat catggagaat gaacacaagg
    17641 ttcttgagca tgagaataat gtgtgcggct tcgggaatac aggttcaatt atatatacct
    17701 atctctatct gggaagattg cgaaatgaca cagagctgat ctccagagcg gccggcttgg
    17761 ccatccagtt ctcggcgaaa gtagtcagca tcatagagaa gcaaagggcg gaaatagatt
    17821 ttgtaagcgg tataagcagc ctgctggtga ttttgtgcag agttaacaag gagtcagctt
    17881 cagcggaact gacggagagt atcggcaaga tcacggacta tatcctgctt gaacttgaga
    17941 cgcacaaagc taatgaggac tatcgcacag gttttgcgca cggttattcg ggtattgtat
    18001 ttgctcttaa tctggcagct tcctatacag ctgtaccgga caccaagctc gaggaattaa
    18061 tcctcttgga gaataacaag tacgataggg taagcggtaa atggtccgat acgaggaaga
    18121 acgacaatat ctatagtgaa gattattggt gccaaggctc accgggtatg tatatttcca
    18181 gaatggaatt gagtcgcaag ctcccggccg aaatgttaat gttagacgaa ttgagggacc
    18241 gttcgctagg atccactcgg gaattcacca actactcact atgccatgga tatcttggga
    18301 atctgctgat tatggaccat gctcaccact cagctggtga cggcttccat ctcccgcgga
    18361 gcggggacga atatgtgggc gggctgggcg tacatacaga atccctcggt ctttatttag
    18421 gtgaagctgg cctagtatat ttcctgataa ctatgttagg gtacgatgtt cctaagattc
    18481 tgtatcttga agtctgatgg tatcaagttg tctactaatc tataacagga gagcatacac
    18541 gtgaagaaca ggataagaat ggtgggacaa ttacatcaga ctgaatgtgg atattgctgc
    18601 ttagcgatga tctccggcta tcatgggtta catgtaacgc tgagagaatt aagggagatc
    18661 gggaatacag gaagagacgg gttaagcctg ctcgatatca tggagatctg tgacaagctg
    18721 aatcttgagg ccagaaccta cgagattgaa gccacggaca cagctaattt cgggctgcct
    18781 tgtattgcct tttgggaaga gaagcacttc gttgtgattg agaaatttga caagaaaggc
    18841 gtctggatct atgatccggc cgggctcgat aaggtcagaa tctcctatga ggaattcaac
    18901 gagaaattca gcaactacat tatagaagtg aaccgcactg agcagaccga ggtacgaaag
    18961 agagtaaatg tgtggcgtcc gtatctgaaa tacattctgg acaataagaa gtttatcgtc
    19021 atattcctgt tctcatctat cttcttgtac ggaataacgt taattttgag ttattttatg
    19081 caggagatta ttgaccggtt aactaacaat acgctgagtg taaatcttgt cttgatttcg
    19141 gcacttcttg ttgtcgcatt tcagaccgtc atcaggctgg tccaaggcaa atccgtgctg
    19201 tatctcaata acaacgtgga cttcaaattc atggatgact tcttttccca tttactcaag
    19261 ctgccgtacc atttcttcca atcccgttca tcaggagata tattatacag cgcctctagt
    19321 atccgggtaa taaggaacac gttatctaca gaagtcataa caagcgcaat gaatctattc
    19381 tttatgttat ttgtgcttat ctacatgttc gtcttctccg aggttattgc cctattgtgc
    19441 tgcaccctga ttatcatcta cggcctgctg cttctcgtga ataccaaata cttgacccga
    19501 ttcaccaata atgaggttat gaatacctcg aaacttcatg ctaaccagaa tgagatgatt
    19561 ttcaacattt tctccgtgaa gatcaacgga attgagggac tggtatacaa agagtggaag
    19621 aaaaagctgg agaactttat tgcttcggtt aaacgcaaag agaacttctc taactatatc
    19681 cagacctcga tcggggcatt tgagacgtta tccccgttat tggtaatctg gttaggcgcc
    19741 tatctctatc tgcaggggat gttaacaaca ggggaaattg tgatgctgta caccctgtcg
    19801 atccagctgt tcaccatttg caaatcatta tttcagctgt attcctcttt tgttacttcg
    19861 accatgtatt tgagcagagt tcatgacgtg ttagccgaag aggaagagaa ggctaatccc
    19921 aatggggtac ggcctgtcct ccatgggaat atccgattag acaatgtcag ctataaatac
    19981 ggcaaaggct ctgtgttaag cgggataacc ctgcagatca atgcgggaga aaaagtggcc
    20041 ctggtgggag aaagcggcag cggaaagagc acattagcca aaataatagt tggactatat
    20101 cccccaaact cgggaaatgt ctattttgac ggttatgaca gctttgatat tgataccaaa
    20161 tacctgaaaa gtctgatcgg gattgtaccg caggaaatca cgctgttcaa taagacaatc
    20221 agagagaata ttatccttca tgatgtggaa gtgacagagg aagagctgga gaaggcagct
    20281 atgaaggcta acatttacga ggatatcatg gacatgccga tgaagttcaa taccttagta
    20341 tcggaatcgg gaaccaatct atccggtggg cagaagcaaa ggattgccat agccagagcc
    20401 ctgatcaaca acccgaagtt catcgtcttt gatgaagcga ccagctcgct ggattacaag
    20461 aatgagaagc agattgatga atacctcaaa gaaatagagt gtacaagaat cattatctcc
    20521 cacaagctta cgtcgattaa ggatgccgac aagatcattg tgctaaagaa tggacaaatt
    20581 gatgcttgcg ggaatcatga ggaactgatc cggaataatg agttctacag gaactacttc
    20641 aatttattgg agtatagccc tggccggtaa tattccctga ctaagcagat tgccttggag
    20701 ttccggggta gtctgtttaa ttttttatga ggaagtgctg gcctaacaag aaaacaaaat
    20761 gttagttatt tatgtgtttt gtttgttttt gtattgctaa gggggtcata ttttgtgata
    20821 atatgaacag taatttaggt atgaagtgaa aacacgggaa taggtgatcg gatgaagggc
    20881 aaagttactg ttcaggagat tgcagacttt gtaggtgtat ccaagttcgc ggtctcccgc
    20941 gcgcttgccg ggaaatcggg agtcagtgag aagacaagag atacgatact acaggcagcc
    21001 gctgaacttg ggtatttcaa gaatagacct aagcgtgtca cgccagcgcc ggccccggag
    21061 ggcggcggca gctggaaggg gaacattctg gttctattcc cgaatatcag gttccagaac
    21121 cgggattctt tatattgggg gcccatcttt gatggagtct cggcccggct gaatgagaag
    21181 gggatcgata ttattacgct gactgagcct tcgacagaag atattttctc gctgatcaat
    21241 ccggatgcgg taagtggagt gattacggta ggaaccgtct cctcttccat tctgaccgag
    21301 attgaccgct tgaagattcc ggtggttatg attgaccata tggaccctgt tctgaaatgt
    21361 gatacggtct tcacagataa ctttatgtcc attaacgaga ttatgaatta tctattaaat
    21421 aaaggctaca gggactttca attcgtcgga tatcctggtt acgcgccaag cttccgggag
    21481 aggtggacgg cttaccgggc ctttcttgaa gagaagggaa ttgaggggaa tcaagctgaa
    21541 ggcttgatct ctccggcaag agaagagctt gcccagacga ttatggatat gaagccgcgg
    21601 gagcttcctg aggtattttt gtgtgcgaat gacatcatgg cttcatttac aattgaggcc
    21661 ctgacggcta aaggaattaa ggtgccaggg cgctgcgtag taaccggctt tgacaatctc
    21721 aatgaggagc tgccgctact cgccactgcc gaggtgaaca aggagcagct ggggatgcgt
    21781 gcggttgacc agattctgtg gcggattcag aatcctcacc atgcgaatga gcgcaagatg
    21841 gtctccacag agatcattgt tcatgaagag aatggaatga agcattgaat tcagtccgaa
    21901 tcgcccagag atagcaggag gatgtagact gcatggaaag ccttttctaa caggaaaggc
    21961 tttttttgtt attatttttc ctatcattta acctaacaaa ttgaataaca taattgaagt
    22021 atttgcaaat ttgttattgt aattatccct aacagatgct acatttgtta tgaaatgcaa
    22081 gagtgttatc ccaaacgcag ggaggaacta agtaatgatt caacaactca acaattggac
    22141 ttttagagca tgtgatgagc agcagtggcg ttctgcggta gtgcctggct gcgtgcatac
    22201 agatttactg cgaaacggac taattcctga tccattctat ggaacgaatg agcacgatct
    22261 gcagtggatt gacaagaagg actgggagta ccaatcagaa tttgaggcag gacccgagct
    22321 gctcgggtta acccggatcg atctggtatt tgaaggtctg gatacctatg cggatgtgta
    22381 cctgaacgag cagccgattc tggcggctga taatatgttc cggatctgga aagttgatgt
    22441 gaaggagcag cttaagccgg ggcttaatca acttcggatt cgttttcgtt caccgattca
    22501 tgaggatctt cctaagcttg agaagctggg gtatgccctt ccggcaccga atgaccagtc
    22561 tgagcttggc gggctagaga ataagagggt aagtattttt gcaaggaagg ccccttacca
    22621 ctatggctgg gactggggac cgcgctttgt gaccagcggc atctggcgtg aagtccggct
    22681 cgaaggatgg tcacagcttc agattaccga tctgtatatt cgccaggacg aagtgactgc
    22741 cgaagcggcc aagcttacgg ctgtagccga agtgaatgct gaggcgaact gggcgggcac
    22801 gcttcgcata acggcaggcg gtaagcagtg ggagcagcca gtccagatta ctgccggcca
    22861 gtctacggtg tctgcggatg tggaactcgc aagtccagat ctatggtggt gtcaggggtt
    22921 aggtgaagcc catatgtaca cgttccaagc tgaactgctg ttcgaagagg aggagcttgc
    22981 gaagaaatcc gttcggacag gattgagaga tctgaagctc atccgtgaaa gggatgaagc
    23041 gggggtatcc ttctatttcc agctgaacgg ggtacctgtc tatgtgaagg gtgcgaacca
    23101 cattccaaat gacagcttta cggcagaggt cactcgtgag cggtatcttc atgagattgt
    23161 cactgcggtg gaatcgaaca tgaacatgct ccgtgtatgg ggcggcggta tttatgaaga
    23221 ggacgtcttc tatgagctgt gtgatgagta tggcctgttg gtatggcagg acttcatgtt
    23281 cgcctgcagt atgtatcccg gagatgaggc tttcttaaat agcgttcgcg cagaggcggt
    23341 agataatgtg aagcgtcttc gcaaccaccc ctccttagcc ctctggtgtg ggaataatga
    23401 gattgattcg gcttgggcgc actatgtgga ggacgcaggc tggggctgga agaaggatta
    23461 cagtcccgag atgcgtgaga agctgtgggc ggattatgaa gcgatcttcc ataagctgct
    23521 gccggaggtt gtctctgagc tgtccgggaa cattgcatac tggccatctt ctccgctccg
    23581 caatctgacc ggggaccaag agcagcacgc gcataagaca accggagacg gggatattca
    23641 ctattggggt gtgtggcatg cgattgagcc tttcgagaac tacaacaaga atgtagggcg
    23701 cttcatgagc gaatacggct tccagtcctt ccctgagttg aagtcggttc ttgaatatgc
    23761 accggaagag gcgctggagc tcgaatccga gattatgctg gcccaccaga agaatggccg
    23821 cgggaatctg ctaattaagg aatacatgga tatgtatctg cctgagccca agaactttaa
    23881 gtcattcctg tatatgagcc aggttctgca ggctgaggcg attaccatgg ctattgaagc
    23941 gcaccgccgc agcaagcctt actgcatggg gacgctgtac tggcagatga acgactgctg
    24001 gccagtggct tcatgggccg gaatggatta tcaagggcgc tggaaagcac tgcagtatgc
    24061 ggtgaagcga agctttgccc ctgtggtggt tattgtacaa tcggtcgggg acgacattaa
    24121 cttctatgct gtatcggatc ttggaacggt gattcaggct gagcttgtta ccgagcttcg
    24181 caagctctct ggagaactga tccttcagaa ggtacattca gttgccctgg gtgcgggcga
    24241 atctacagaa gtattccata tcacaaggaa tgagctgctg ggcggcctgg attctcatga
    24301 cgtaatcctg acagcggtgc tgaagcaggg cggagacgtc attgcggcaa gagagcatta
    24361 cctggcacct gagaaagagc ttaagctggt taagccgaat atcaagctga ccgaagccac
    24421 agatgagagc ggcggtacag tctatacact ggagacggac accttggcca gacaggtatg
    24481 gctatccaca ccggaagaag gcattttctc cgacaacttc ttcgatctgg ttccgggtca
    24541 gccaagaaca gtagagttca agctccggtc cggagaaggc tcattcgtac ctgctgcggc
    24601 atcccgattg gacatcaaat cgatggccga ctttgtaggt gaggcatcgc tcgtgcagct
    24661 aagtgagatt aaagcttcca agtaagcagc tccaaggcaa ggcttatatt gacagataga
    24721 tggactcatc ctctgctagt tcgggggatg agttttttgc ttttcggctc ttcaggcatg
    24781 atttcggtgc ttgtgcatat acatcaaaac atactgaaat taatcctata aatttagtat
    24841 acattatgat acaataatca ggcacatcat ctttctggtg ctgtaaggat tctctgtgta
    24901 ccagatccgg gtaatcattc ataattagtg cgataagagg gggatattta ttatgactac
    24961 attttgggtc atactcaacg tagttgttat gctggttctt gtgggctttt tactgtggct
    25021 gcagaagaag catgtatcat ttaccaagcg tgtatttgcc gggctgggcc tggggattgt
    25081 attcggggtt attttgcagc ttgtatcgaa gcctgattca gaagtggtgg ccaagtcaac
    25141 agattggttc aatctgattg gttacggtta tgtgggactt cttcagatga ttgttgtgcc
    25201 actgattatg gtgtcgatca tctcggcgat catgaacctg aagggcaagc agaacctggg
    25261 caagatcagt gcttcaatca ttgctgtact gctgattacc accgccattg cggcgtctgt
    25321 aagtattgta acgagcctta gcttcaacct gaaggcgatc gagatccaga gcggggataa
    25381 agagcagcag cagggcgcga agctggagga acgccttggt gatgtgaagg atctgacgat
    25441 tcctcagcaa attcttgaat ttattcctac caatccgttc gaggatatga ccggagcccg
    25501 ccgttcttct acgctggctg tcgttatttt ctccgcattc atcgggattg ctgtactggg
    25561 tctggataag aagaagccgg agcaggcaga cacttttcgt aaaatagtag atgccgtata
    25621 cgccgtagtt atgcgcattg taaccctggt gctcagacta accccttacg ggattctagc
    25681 cctgatggcg aagacgattg ccacgacgaa tgcggattcg atcgtgaagc tgatcaagtt
    25741 cgtaggggct tcttatgtgg cacttatcat tatgttcatt atccacctga ttctgctggc
    25801 cttgttcggc tacaatccgg tcagatacgt tcgcaaggtg cttccaacgc ttgtgttcgc
    25861 gttcacttca cgttcaagcg cggcaacgat tccgcttaat gtggagacac agacgaagaa
    25921 gcttggcgtt ccaacaggga tcgccaacct ggcggcgagc ttcggggcta ccatcggcca
    25981 gaatggctgc gccgggattt atcctgcgat gctggctgtc atgatcgcgc caactgtcgg
    26041 catagatccg cttagctggg atttcatcct gaccctgatt cttgtggtaa ccatcagttc
    26101 attcggggta gccggagtcg gtggcggagc aaccttcgct tccctgatcg tgctctccac
    26161 gatgaacctg ccggttgcgc tggccggtct cttaatctcg gttgagccgc tgatcgatat
    26221 gggccgtacg gctctgaacg tcaacgattc tattacagct ggtgtaatta caggtaagat
    26281 tcttggtgag aatgacaaag aagtgttcga caaggatgtg gacctggacg tagcaacagc
    26341 ttaataggaa gtcgtgctga attatatagc tgcgtaacaa agaaatcccg gactgctgag
    26401 gcggtccggg atttctttgt atatgcggga atgctgcgtt atcggtcagc cgtaagtcac
    26461 atcatggcga gtatactgtt gcaaatctat acaaccaaag gcgatcaaat gtcctcaaac
    26521 cggatgtcat gagatttagc actcgctgcg gcaaagtgaa gcaatcgtgc gccttcttca
    26581 gttagagcct ccttctcttg aatcgttagc ggcttaaagg gctcaattag aaggactgca
    26641 cgtcctctct cacgcttgag ggtccaagtt ccacagacga acccacccag aagcaaagtg
    26701 ggcctgacca agccgttctt ggtacataca cgaggctgaa tgttcttgtc gatgattcgc
    26761 gtacgatcgg cgtaggatag cagcatattg tcgaattcac ccaggaaccg tggaggtgca
    26821 ggcgtactag gatcaggtct tggtgctcct ggcagatcga acagctcgga tccgtgttca
    26881 tctcgaaatg tgatcagctg cggcctaaga cgctccacag cctcactcag ccgggtgagt
    26941 cctgaccaga cttgaatatc cttcactgaa gccggaccga aggcggcgag ataacgaacc
    27001 accatctgat ctgcggacga cacgggggat agcggctggc ctagccattt ctccgcagag
    27061 gtatgaacgg cctgcccgct cttcccccat aatccgcggg gcggcagctg cacgagcgga
    27121 actgaatttc gcacggcagc cgagagagcg gaaggttcgt atccagggta gatgacctgc
    27181 aggctttggc caagctgctg agcggttaat ggagtctctt ccacgaggtc ccttcctctg
    27241 gaggccagct cattaagatt aaggcctgtt agagccttgc cgaaggcacc ttgcaagctg
    27301 cggtccagca ccggttgcag attaggccgg aaagacaggc aatcccctgc ggataccaga
    27361 tgaatggtgg agcgcatcaa ggctatgcgc accgcctttt tctcctgaag aagatgggat
    27421 aattcctctg gattaaatgt ctcaagccgc gcccagagtg cgaagtaggg ggcgctcgga
    27481 gactgggctt gcagcccggc tagccgctct atggcctcaa gggaaggcag ctcctcgcgg
    27541 cacagaagca tttgtcttgc cagcagggcc cggttgaggg cgcgggtact gagcacagga
    27601 agctcctctt tgccagagat ggcttctggg gctgtgttgt cagaactcat atccagtgcc
    27661 tccaatccaa tttattctga gtgttctcag cctgggacag cagaattaga aatggtcact
    27721 tagaataccc tcgaaaccta gcttggacct cgcaccctca caacatattg tcagagtgcg
    27781 aggtcacatg ggaattgagt tcctctctgt cacttgcccg agctcggcca gtgtgccgga
    27841 tgaatgagag agaggggcag ctgtgtcgct gcatcgccct tggcagcatt cacttgggct
    27901 tgagttagga agatactgtg cgatagattg gctcccctaa ggtcggtatc ccggaggtcc
    27961 gccccaatca gatctgctcc tctgaggtcg gcctctctca gatcggcggc aatcaagtag
    28021 gccccccgca gattggctcc actaagattg gcacctttga gcttggccgc aatcaggtct
    28081 gcgccccggc caatcccttt cttcgggcga ccttgagatt gcttatactt aagcttggct
    28141 tcctcacgta caagctcgct tgtccttagc agcagaatat taaccttggc ccggtgggct
    28201 gccacatcaa gctgaacaag agagtccgga gtgagctggg tcaggtgttc ggtctcggca
    28261 agagcgagtt caagctcatc ccggatttca cgtgcaggct ccagggttaa cgcttcgttc
    28321 agataccaga gcagctcgtg gagctgccac attacgggaa atacctcgta catttgcttg
    28381 gccgattcag gatgggcacg ccagtcacgt cccccatagg taacctggga tacctgttgt
    28441 cctgcgccaa agcagtcata taccgtacac ccacgaaatc ctaacggcct caggtta
//
