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Overview
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1.10

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP084530.1 (Paenibacillus sp. YPG26)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | NRPS,transAT-PKS | 226,078 | 300,661 |  |
Region 2 | terpene-precursor | 303,541 | 325,925 |
Region 3 | lanthipeptide-class-ii | 453,983 | 482,479 |
Region 4 | proteusin | 884,917 | 905,156 |
Region 5 | terpene-precursor | 1,704,292 | 1,725,167 |  |
Region 6 | NI-siderophore | 1,993,010 | 2,024,674 | Low | staphyloferrin B | other:other
Region 7 | T3PKS,other | 2,097,249 | 2,156,641 |  |
Region 8 | opine-like-metallophore | 2,185,600 | 2,207,740 | High | bacillopaline | other:other
Region 9 | cyclic-lactone-autoinducer | 2,638,869 | 2,659,399 |
Region 10 | terpene | 3,549,555 | 3,570,478 |

NZ_CP084530.1 - Region 1 - NRPS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 226,078 - 300,661 nt. (total: 74,584 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: acylase
LDO05_RS01320: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: esterase phosphatase
LDO05_RS01310: thioesterase

smcogs
  SMCOG1004: thioesterase

LDO05_RS01330: FkbH like protein

smcogs
  SMCOG1256: FkbH like protein

Ligases: ligase
LDO05_RS01290: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

LDO05_RS01300: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

LDO05_RS01315: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | transAT-PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002135.2 |  |  | 0.97 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  |  | 0.92 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001128.4 |  |  | 0.91 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  | 0.91 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  |  | 0.90 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001261.3 |  |  | 0.89 | NRPS | AM-toxin | Alternaria alternata
BGC0001132.4 |  |  | 0.89 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  |  | 0.82 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001758.4 |  |  | 0.82 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001240.4 |  |  | 0.78 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.78 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.76 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001128.4 |  | 0.76 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.76 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001261.3 |  | 0.75 | NRPS | AM-toxin | Alternaria alternata
BGC0001132.4 |  | 0.75 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001166.5 |  | 0.73 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001825.4 |  | 0.73 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001758.4 |  | 0.72 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.18 out of 23.79
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.95 out of 20.97
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19
Confidence: medium
Additional weak hits (20):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.00 out of 39.62
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.25 out of 26.85
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.12 out of 26.06
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.21 out of 31.73
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.07 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.99 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.98 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.01 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.82 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.31 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.42 out of 26.06
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.81 out of 27.78
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.70 out of 32.93
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.29 out of 32.93
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.13 out of 29.65
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.90 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.41 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.53 out of 28.14
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.43 out of 26.85
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 20.98 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 226077 - 300661:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Phe) + (Cys) + (fatty_acid - Ser - Ser) + (mal - Ser)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
LDO05_RS01290: Phe
Search NORINE for peptide: strict or relaxed
AMP-binding (267..660): Phe
nrpys: Phe

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Unpolar aromatic ring (Phe, Trp)
  Single AA prediction:
    phe (Phe)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LYFAFDASIWEMTLVTAGSVNAYGPTETTVCATA
  Nearest Stachelhaus code(s):
    Phe DAWTVAAVCK (82% 8Å match)
  Stachelhaus code match:
    100% (strong)

LDO05_RS01300: Cys
Search NORINE for peptide: strict or relaxed
AMP-binding (689..966): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TWVTFDLSVYDGDSLLSGDAALGGATEACIWSNY
  Nearest Stachelhaus code(s):
    Cys DLYNLSLIWK (76% 8Å match)
  Stachelhaus code match:
    90% (moderate)

LDO05_RS01315: fatty_acid - Ser - Ser
Search NORINE for peptide: strict or relaxed
CAL_domain (173..482): fatty_acid
minowa: fatty_acid

Prediction, score:
  fatty_acid: 122.8
  NH2: 32.3
  shikimic_acid: 0.0
  Acetyl-CoA: 0.0
  AHBA: 0.0

AMP-binding (1158..1623): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFFASGEINLYGPTEATVDVTV
  Nearest Stachelhaus code(s):
    Ser DVWHFSLVDK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2280..2696): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFFASGEINLYGPTEATVDVTV
  Nearest Stachelhaus code(s):
    Ser DVWHFSLVDK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

LDO05_RS01320: mal
PKS_AT (6..296): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 79.2%
  inactive: 70.8%
  Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 107.9
  Methoxymalonyl-CoA: 50.5
  inactive: 43.3
  Methylmalonyl-CoA: 40.1
  Propionyl-CoA: 26.7
  Ethylmalonyl-CoA: 21.0
  CHC-CoA: 15.0
  2-Methylbutyryl-CoA: 11.3
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

LDO05_RS01330: Ser
Search NORINE for peptide: strict or relaxed
AMP-binding (2478..2894): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFFASGEINLYGPTEATVDVTV
  Nearest Stachelhaus code(s):
    Ser DVWHFSLVDK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CcpA | Catabolite control protein A
IolR | Regulator of the inositol catabolism
ZuR variant 1 | Zinc-responsive repressor

NZ_CP084530.1 - Region 2 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 303,541 - 325,925 nt. (total: 22,385 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
LDO05_RS01465: FAD dependent oxidoreductase

smcogs
  SMCOG1103: FAD dependent oxidoreductase

Ligases: synthetase
LDO05_RS01480: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Translocases: transporter
LDO05_RS01445: sugar-binding lipoprotein

smcogs
  SMCOG1143: sugar-binding lipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000528.5 |  | 0.39 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001576.3 |  | 0.39 | ribosomal | divamide A | Prochloron didemni
BGC0001456.3 |  | 0.38 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000664.5 |  | 0.37 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000643.3 |  | 0.37 | terpene | carotenoid | Brevundimonas vesicularis
BGC0000557.5 |  | 0.37 | ribosomal | streptococcin A-FF22 | Streptococcus pyogenes
BGC0000043.5 |  | 0.36 | PKS | curacin A | Moorea producens 19L
BGC0002442.3 |  | 0.36 | ribosomal | toyoncin | Bacillus toyonensis
BGC0001789.3 |  | 0.35 | ribosomal | suicin 90-1330 | Streptococcus suis
BGC0000498.5 |  | 0.35 | ribosomal | bovicin HJ50 | Streptococcus equinus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000528.5 |  | 0.39 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001576.3 |  | 0.39 | ribosomal | divamide A | Prochloron didemni
BGC0001456.3 |  | 0.38 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000664.5 |  | 0.37 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000643.3 |  | 0.37 | terpene | carotenoid | Brevundimonas vesicularis
BGC0000557.5 |  | 0.37 | ribosomal | streptococcin A-FF22 | Streptococcus pyogenes
BGC0000043.5 |  | 0.36 | PKS | curacin A | Moorea producens 19L
BGC0002442.3 |  | 0.36 | ribosomal | toyoncin | Bacillus toyonensis
BGC0001789.3 |  | 0.35 | ribosomal | suicin 90-1330 | Streptococcus suis
BGC0000498.5 |  | 0.35 | ribosomal | bovicin HJ50 | Streptococcus equinus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
LDO05_RS01480: PT_FPPS_like
Domain 1 (535 - 756): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.46 out of 27.78
Confidence: medium
Additional weak hits (4):
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.11 out of 30.11
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.66 out of 31.73
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.17 out of 25.75
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.80 out of 26.12
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT | Regulator of MSHA biosynthesis

NZ_CP084530.1 - Region 3 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 453,983 - 482,479 nt. (total: 28,497 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
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Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
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Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
LDO05_RS02080: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

LDO05_RS02095: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000517.4 |  | 0.56 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001210.5 |  | 0.55 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000623.3 |  | 0.54 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000525.5 |  | 0.53 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000516.4 |  | 0.53 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000520.5 |  | 0.52 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0001229.4 |  | 0.52 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000552.3 |  | 0.52 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0000555.3 |  | 0.52 | ribosomal | staphylococcin C55 α, staphylococcin C55 β | Staphylococcus aureus
BGC0001311.5 |  | 0.51 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000517.4 |  | 0.56 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001210.5 |  | 0.55 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000623.3 |  | 0.54 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000525.5 |  | 0.53 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000516.4 |  | 0.53 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000520.5 |  | 0.52 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0001229.4 |  | 0.52 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000552.3 |  | 0.52 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0000555.3 |  | 0.52 | ribosomal | staphylococcin C55 α, staphylococcin C55 β | Staphylococcus aureus
BGC0001311.5 |  | 0.51 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for LDO05_RS02080

LDO05_RS02075
Leader:
MLENRNPFIVFNQEAKMEALSPVLAEELIEVDLSIQGG
Core:
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
Core with dehydrations:
Cys Dhb Dhb N Dhb F Dhb L Dha N Y L G N N G G W Cys Dhb L Dhb K E Cys Q R Dha Cys N

#### antiSMASH-DB 4.0 matches for LDO05_RS02075

100.0%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide
Lanthipeptides: LDO05_RS02075_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
93.3%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide
Lanthipeptides: C8268_RS00165_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F T L S+Y L G N G G W C T L T K E C Q R S C N
1
C T T N T F T L S D Y L G N K G G W C T L T K E C Q R S C N
30
80.0%
NZ_BJTV01000004.1 and 1 other:
NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide
Lanthipeptides: TNCT1_RS10200_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F+L S+ L G N+G G W C T L T K E C Q +C N
1
C T T N T F S L S D A L G N H G G W C T L T K E C Q A N C N
30
with 99 more sequence matches
Only the first 10 are displayed here.
80.0%
NZ_BNBV01000031.1 and 1 other:
NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide
Lanthipeptides: IE286_RS22995_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F+L S+ L G N+G G W C T L T K E C Q +C N
1
C T T N T F S L S D A L G N S G G W C T L T K E C Q P N C N
30
80.0%
NZ_CP047419.1 and 3 others:
NZ_CP047419.1 Lanthipeptides: GTU71_RS12805_lanthipeptide NZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide NZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide
Lanthipeptides: GTU71_RS12805_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C
29
C T T N T F T L S N L G N G G W C T L T E C Q +C
1
C T T N T F T L S N V L G N Q G G W C T L T V E C Q P N C
29
80.0%
NZ_CP107567.1 and 3 others:
NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide
Lanthipeptides: OGH68_RS19760_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F+L S++L G N G G W C T L T K E C Q +C N
1
C T T N T F S L S D W L G N Q G G W C T L T K E C Q P N C N
30
76.7%
NZ_AKXV01000031.1 and 4 others:
NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptide NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptide NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide
Lanthipeptides: Y19_RS0109895_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C+T N T F+L S++L G N G G W C T L T K E C Q +C N
1
C S T N T F S L S D F L G N Q G G W C T L T K E C Q P N C N
30
76.7%
NZ_BMMP01000005.1 and 3 others:
NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptide NZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide NZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide
Lanthipeptides: IEY56_RS28370_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F+L S+ L G N G G W C T L T E C Q +C N
1
C T T N T F S L S D V L G N T G G W C T L T V E C Q P N C N
30
76.7%
NZ_BNCA01000011.1 and 1 other:
NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15865_lanthipeptide
Lanthipeptides: IE314_RS15865_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F+L S+ +G N+G G W C T L T K E C Q +C N
1
C T T N T F S L S D A V G N H G G W C T L T K E C Q P N C N
30
76.7%
NZ_CP016795.1 and 5 others:
NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptide NZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptide NZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptide NZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide NZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide
Lanthipeptides: BC342_RS18360_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F+L S+ L G N+G G W C T L T K E C Q +C+
1
C T T N T F S L S D A L G N H G G W C T L T K E C Q P N C S
30
76.7%
NZ_CP043317.1 and 1 other:
NZ_CP043317.1 Lanthipeptides: FYC74_RS17680_lanthipeptide
Lanthipeptides: FYC74_RS17680_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F+L S+ L G N+G G W C T L T K E C Q +C+
1
C T T N T F S L S D S L G N H G G W C T L T K E C Q P N C S
30
76.7%
NZ_MJEJ02000054.1 and 3 others:
NZ_MJEJ02000054.1 Lanthipeptides: BH683_RS28205_lanthipeptide NZ_QJSP01000005.1 Lanthipeptides: DFR67_RS09500_lanthipeptide NZ_QJSP01000005.1 Lanthipeptides: DFR67_RS09500_lanthipeptide
Lanthipeptides: BH683_RS28205_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C
29
C T T N T F T L S++L G N+G G W C T L T K E Q +C
1
C T T N T F T L S D F L G N D G G W C T L T K E S Q N N C
29
73.3%
NZ_JAASAG010000001.1 and 1 other:
NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS30395_lanthipeptide
Lanthipeptides: HCC61_RS30395_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F+L S+ L N G G W C T L T E C Q +C N
1
C T T N T F S L S D A L T N T G G W C T L T V E C Q P N C N
30

#### MIBiG 4.0 matches for LDO05_RS02075

86.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F+L S N L G N N G G W C T L T K E C Q +C N
1
C T T N T F S L S N A L G N N G G W C T L T K E C Q P N C N
30
46.7%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
6
F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
+ +S L G N G +C T L T E C S C N
4
Y N I S C R L G N K G A Y C T L T V E C M P S C N
28
23.1%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
19
C T L T K E C Q R S C N
30
C T L+K E C Q +C N
28
C T L S K E C Q P N C N
39
with 1 more sequence matches
10.0%
BGC0000503.5 (cinA):
Lanthipeptide: cinnamycin
25
C Q R S C N
30
C++S C+
1
C R Q S C S
6
LDO05_RS02090
Leader:
MTKREIRREVLANNTFICEKEERELQDKVGA
Core:
A I P I T T S S W I C G V A S A A F C P S T A C T S K C
Core with dehydrations:
A I P I Dhb Dhb Dha Dha W I Cys G V A Dha A A F Cys P Dha Dhb A Cys Dhb Dha K Cys

#### antiSMASH-DB 4.0 matches for LDO05_RS02090

100.0%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide
Lanthipeptides: LDO05_RS02090_lanthipeptide
1
A I P I T T S S W I C G V A S A A F C P S T A C T S K C
28
A I P I T T S S W I C G V A S A A F C P S T A C T S K C
1
A I P I T T S S W I C G V A S A A F C P S T A C T S K C
28
64.5%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00150_lanthipeptide
Lanthipeptides: C8268_RS00150_lanthipeptide
1
A I P I T T S S W I C G V A S A A F C P S T A C T S K C
28
A+ I T T S S W I C G +A A C P S T A C T C
4
A L G I T T S S W I C G F V T A A L C P S T A C T G D C
31
53.1%
NZ_CP006058.1 and 25 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS19790_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptide NZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptide NZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide
Lanthipeptides: BAMY6639_RS19790_lanthipeptide
5
T T S S W I C G V-A S A A F C P S T A C T S K C
28
T S S C G V +A A F C P S T C T S C
8
T P S S L P C G V F V T A A F C P S T K C T S S C
32
with 102 more sequence matches
Only the first 10 are displayed here.
50.0%
NZ_CP013862.1 and 1 other:
NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide
Lanthipeptides: AOX59_RS09365_lanthipeptide
5
T T S S W I C G V A-S A A F C P S T A C T S K C
28
T S S C G+A S A F C P+T C T S+C
8
T P S S V A C G I A V S A L F C P T T K C T S Q C
32
50.0%
NZ_FOBE01000018.1:
Lanthipeptides: BMW61_RS21935_lanthipeptide
1
A I P I T T S S W I C G V A S A A F C P S T A C T S K C
28
+P I T I A S A F C P S C+S K C
5
G V P I T V P I T I--A A S T A F C P S I K C S S K C
30
46.4%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00390_lanthipeptide
Lanthipeptides: CWT12_RS00390_lanthipeptide
5
T T S S W I C G V A-S A A F C P S T A C T S K C
28
T S S W C G+ + C P+ A C+S K C
3
T P S S W P C G I G I T T T V C P T A A C S S K C
27
46.4%
NZ_CP039292.1 and 1 other:
NZ_CP039292.1 Lanthipeptides: E4J16_RS14990_lanthipeptide
Lanthipeptides: E4J16_RS14990_lanthipeptide
5
T T S S W I C G V A-S A A F C P S T A C T S K C
28
T S S W C G+ + C P+ C T S K C
3
T P S S W P C G I G I T T T I C P T A V C T S K C
27
46.4%
NZ_PCGR01000003.1 and 1 other:
NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide
Lanthipeptides: CQS04_RS09625_lanthipeptide
1
A I P I T T S S W I C G V A S A A F C P S T A C T S K C
28
A P + I G S A C P+T A C T C
1
A T P T I V I T A I T G Y I S A N S C P T T A C T R A C
28
44.7%
NC_006322.1 and 7 others:
NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide
Lanthipeptides: BLI_RS20290_lanthipeptide
3
P I T T S S W I C G V A----S A A F C P S T A C T S K C
28
P T T S S W C A S A+ C P+T C T S+C
9
P A T T S S W T C I T A G V T V S A S L C P T T K C T S R C
38
43.8%
NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00915_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide
Lanthipeptides: BALI_RS00915_lanthipeptide
5
T T S S W I C G-V A S A A F C P S T A C T S K C
28
T S S C G + +A +C P S A C T S C
8
T P S S L P C G T L V T A V W C P S N A C T S D C
32
43.6%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide
Lanthipeptides: P40081_RS37160_lanthipeptide
3
P I T T S S W I C G V A----S A A F C P S T A C T S K C
28
P+T T S S W C + S A C P+T C T S K C
10
P L T T S S W P C V I G A V D I S A N L C P T T K C T S K C
39
41.4%
NZ_CP040938.1 and 1 other:
NZ_CP040938.1 Lanthipeptides: B5772_RS02455_lanthipeptide
Lanthipeptides: B5772_RS02455_lanthipeptide
4
I T T S S W I C G V A S A A F C P S T A C T S K C
28
I T T S +A S A C P+ C++K C
1
I T T S I P C A V M A S T A I C P T L V C S N K C
25
41.4%
NZ_JABBGE010000004.1 and 1 other:
NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13570_lanthipeptide
Lanthipeptides: HHL19_RS13570_lanthipeptide
7
S S W I C G V A-------S A A F C P S T A C T S K C
28
++W C V S A+ C P+T C T S+C
1
T T W S C A V V T A V A T L V S A S A C P T T K C T S Q C
29

#### MIBiG 4.0 matches for LDO05_RS02090

32.1%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
18
F C P S T A C T S K C
28
F C P+T C T S K C
16
F C P T T K C T S K C
26
29.7%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
15
S A A F C P S T A C T S K C
28
S A A F C P+T C T S+C
24
S A A F C P T T K C T S R C
37
allorf_0460692_0460856
Leader:
MKVQVLILVKMISQASHIIPLYKYVLSKNLLEKKHRPAA
Core:
S R S C M A V L S H I L D A I
Core with dehydrations:
Dha R Dha Cys M A V L Dha H I L D A I

#### antiSMASH-DB 4.0 matches for allorf_0460692_0460856

100.0%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: allorf_0460692_0460856_lanthipeptide
Lanthipeptides: allorf_0460692_0460856_lanthipeptide
1
S R S C M A V L S H I L D A I
15
S R S C M A V L S H I L D A I
1
S R S C M A V L S H I L D A I
15
allorf_0461347_0461490
Leader:
MLKMKEVLSFLPIDLKEWSKAETWGLLQKSPGS
Core:
I P I S E S I C T P P D I L
Core with dehydrations:
I P I Dha E Dha I Cys Dhb P P D I L

#### antiSMASH-DB 4.0 matches for allorf_0461347_0461490

100.0%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: allorf_0461347_0461490_lanthipeptide
Lanthipeptides: allorf_0461347_0461490_lanthipeptide
1
I P I S E S I C T P P D I L
14
I P I S E S I C T P P D I L
1
I P I S E S I C T P P D I L
14
18.8%
NC_014479.1 and 9 others:
NZ_CP026362.1 Lanthipeptides: BV11031_RS00400_lanthipeptide NZ_CP033052.1 Lanthipeptides: D9779_RS17315_lanthipeptide NZ_CP051464.1 Lanthipeptides: HC660_RS17030_lanthipeptide NZ_JALAKK010000002.1 Lanthipeptides: MOB09_RS02800_lanthipeptide NZ_JALAKO010000014.1 Lanthipeptides: MOB26_RS08535_lanthipeptide NZ_JALAOG010000003.1 Lanthipeptides: MOC96_RS02500_lanthipeptide NZ_JALAPG010000043.1 Lanthipeptides: MOC70_RS16815_lanthipeptide NZ_JALAQI010000009.1 Lanthipeptides: MOD13_RS06065_lanthipeptide NZ_NXEM01000027.1 Lanthipeptides: CPT06_RS15285_lanthipeptide
Lanthipeptides: BSUW23_RS16845_lanthipeptide
4
S E S I C T P P D I
13
S E S+C T P +
3
S E S L C T P G C V
12
18.8%
NC_016047.1 and 6 others:
NZ_CP025079.1 Lanthipeptides: BVQ_RS17705_lanthipeptide NZ_CP047644.1 Lanthipeptides: GNE05_RS17275_lanthipeptide NZ_CP099859.1 Lanthipeptides: NIZ95_RS16280_lanthipeptide NZ_CP101621.1 Lanthipeptides: NN913_RS16115_lanthipeptide NZ_KZ848487.1 Lanthipeptides: DSL71_RS15965_lanthipeptide NZ_MUXL01000003.1 Lanthipeptides: B0W20_RS12275_lanthipeptide
Lanthipeptides: GYO_RS39160_lanthipeptide
4
S E S I C T P
10
S E S+C T P
3
S E S V C T P
9
with 3 more sequence matches
18.8%
NZ_CP021903.1 and 20 others:
NZ_CP023409.1 Lanthipeptides: Bateq7PJ16_RS18530_lanthipeptide NZ_CP026036.1 Lanthipeptides: C2H93_RS15000_lanthipeptide NZ_CP028218.1 Lanthipeptides: C7M30_RS14555_lanthipeptide NZ_CP035167.1 Lanthipeptides: EQJ08_RS17140_lanthipeptide NZ_CP035226.1 Lanthipeptides: EQW70_RS18175_lanthipeptide NZ_CP045006.1 Lanthipeptides: F9B13_RS03875_lanthipeptide NZ_CP076083.1 Lanthipeptides: KFF76_RS16710_lanthipeptide NZ_CP079759.1 Lanthipeptides: KXZ66_RS17780_lanthipeptide NZ_CP080508.1 Lanthipeptides: K0V03_RS06525_lanthipeptide NZ_CP089148.1 Lanthipeptides: LRO88_RS19055_lanthipeptide NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04985_lanthipeptide NZ_JALAVX010000009.1 Lanthipeptides: MOE40_RS09385_lanthipeptide NZ_JAMYDW010000007.1 Lanthipeptides: NHM07_RS16180_lanthipeptide NZ_JAQOXM010000001.1 Lanthipeptides: PO770_RS03875_lanthipeptide NZ_NJRD01000003.1 Lanthipeptides: CE053_RS07200_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18435_lanthipeptide NZ_SORJ01000001.1 Lanthipeptides: BJ795_RS01490_lanthipeptide NZ_VFNF01000001.1 Lanthipeptides: FB592_RS01525_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03850_lanthipeptide NZ_VLJL01000012.1 Lanthipeptides: L604_RS09425_lanthipeptide
Lanthipeptides: CD007_RS17065_lanthipeptide
4
S E S I C T P
10
S E S+C T P
3
S E S L C T P
9
18.8%
NZ_JAMDIB010000004.1:
Lanthipeptides: M5P35_RS04030_lanthipeptide
4
S E S I C T P P D
12
S+S+C T P P
3
S K S L C T P P G
11
13.7%
NZ_JADMPO010000001.1:
Lanthipeptides: allorf_303731_303931_lanthipeptide
1
I P I S E S I C T P P
11
I P I S C+P P
8
I P I S N L F C S P P
18
allorf_0463481_0463591
Leader:
MRLKSPFCIIIFYFFIIINYTLHGS
Core:
S C K Y W I A S L L P
Core with dehydrations:
Dha Cys K Y W I A Dha L L P

#### antiSMASH-DB 4.0 matches for allorf_0463481_0463591

100.0%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: allorf_0463481_0463591_lanthipeptide
Lanthipeptides: allorf_0463481_0463591_lanthipeptide
1
S C K Y W I A S L L P
11
S C K Y W I A S L L P
1
S C K Y W I A S L L P
11
14.3%
NZ_ML219773.1:
Lanthipeptides: allorf_1335288_1335458_lanthipeptide
3
K Y W I A S L L P
11
+Y W+ L+P
13
R Y W V D R L V P
21
12.1%
NZ_MKZS01000001.1:
Lanthipeptides: allorf_3081872_3082018_lanthipeptide
4
Y W I A S L L P
11
+W I+ +L P
20
F W I S D M L P
27

#### Lanthipeptide(s) for LDO05_RS02095

LDO05_RS02075
Leader:
MLENRNPFIVFNQEAKMEALSPVLAEELIEVDLSIQGG
Core:
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
Core with dehydrations:
Cys Dhb Dhb N Dhb F Dhb L Dha N Y L G N N G G W Cys Dhb L Dhb K E Cys Q R Dha Cys N

#### antiSMASH-DB 4.0 matches for LDO05_RS02075

100.0%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide
Lanthipeptides: LDO05_RS02075_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
93.3%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide
Lanthipeptides: C8268_RS00165_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F T L S+Y L G N G G W C T L T K E C Q R S C N
1
C T T N T F T L S D Y L G N K G G W C T L T K E C Q R S C N
30
80.0%
NZ_BJTV01000004.1 and 1 other:
NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide
Lanthipeptides: TNCT1_RS10200_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F+L S+ L G N+G G W C T L T K E C Q +C N
1
C T T N T F S L S D A L G N H G G W C T L T K E C Q A N C N
30
with 99 more sequence matches
Only the first 10 are displayed here.
80.0%
NZ_BNBV01000031.1 and 1 other:
NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide
Lanthipeptides: IE286_RS22995_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F+L S+ L G N+G G W C T L T K E C Q +C N
1
C T T N T F S L S D A L G N S G G W C T L T K E C Q P N C N
30
80.0%
NZ_CP047419.1 and 3 others:
NZ_CP047419.1 Lanthipeptides: GTU71_RS12805_lanthipeptide NZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide NZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide
Lanthipeptides: GTU71_RS12805_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C
29
C T T N T F T L S N L G N G G W C T L T E C Q +C
1
C T T N T F T L S N V L G N Q G G W C T L T V E C Q P N C
29
80.0%
NZ_CP107567.1 and 3 others:
NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide
Lanthipeptides: OGH68_RS19760_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F+L S++L G N G G W C T L T K E C Q +C N
1
C T T N T F S L S D W L G N Q G G W C T L T K E C Q P N C N
30
76.7%
NZ_AKXV01000031.1 and 4 others:
NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptide NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptide NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide
Lanthipeptides: Y19_RS0109895_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C+T N T F+L S++L G N G G W C T L T K E C Q +C N
1
C S T N T F S L S D F L G N Q G G W C T L T K E C Q P N C N
30
76.7%
NZ_BMMP01000005.1 and 3 others:
NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptide NZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide NZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide
Lanthipeptides: IEY56_RS28370_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F+L S+ L G N G G W C T L T E C Q +C N
1
C T T N T F S L S D V L G N T G G W C T L T V E C Q P N C N
30
76.7%
NZ_BNCA01000011.1 and 1 other:
NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15865_lanthipeptide
Lanthipeptides: IE314_RS15865_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F+L S+ +G N+G G W C T L T K E C Q +C N
1
C T T N T F S L S D A V G N H G G W C T L T K E C Q P N C N
30
76.7%
NZ_CP016795.1 and 5 others:
NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptide NZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptide NZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptide NZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide NZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide
Lanthipeptides: BC342_RS18360_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F+L S+ L G N+G G W C T L T K E C Q +C+
1
C T T N T F S L S D A L G N H G G W C T L T K E C Q P N C S
30
76.7%
NZ_CP043317.1 and 1 other:
NZ_CP043317.1 Lanthipeptides: FYC74_RS17680_lanthipeptide
Lanthipeptides: FYC74_RS17680_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F+L S+ L G N+G G W C T L T K E C Q +C+
1
C T T N T F S L S D S L G N H G G W C T L T K E C Q P N C S
30
76.7%
NZ_MJEJ02000054.1 and 3 others:
NZ_MJEJ02000054.1 Lanthipeptides: BH683_RS28205_lanthipeptide NZ_QJSP01000005.1 Lanthipeptides: DFR67_RS09500_lanthipeptide NZ_QJSP01000005.1 Lanthipeptides: DFR67_RS09500_lanthipeptide
Lanthipeptides: BH683_RS28205_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C
29
C T T N T F T L S++L G N+G G W C T L T K E Q +C
1
C T T N T F T L S D F L G N D G G W C T L T K E S Q N N C
29
73.3%
NZ_JAASAG010000001.1 and 1 other:
NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS30395_lanthipeptide
Lanthipeptides: HCC61_RS30395_lanthipeptide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F+L S+ L N G G W C T L T E C Q +C N
1
C T T N T F S L S D A L T N T G G W C T L T V E C Q P N C N
30

#### MIBiG 4.0 matches for LDO05_RS02075

86.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
C T T N T F+L S N L G N N G G W C T L T K E C Q +C N
1
C T T N T F S L S N A L G N N G G W C T L T K E C Q P N C N
30
46.7%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
6
F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
+ +S L G N G +C T L T E C S C N
4
Y N I S C R L G N K G A Y C T L T V E C M P S C N
28
23.1%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
19
C T L T K E C Q R S C N
30
C T L+K E C Q +C N
28
C T L S K E C Q P N C N
39
with 1 more sequence matches
10.0%
BGC0000503.5 (cinA):
Lanthipeptide: cinnamycin
25
C Q R S C N
30
C++S C+
1
C R Q S C S
6
LDO05_RS02090
Leader:
MTKREIRREVLANNTFICEKEERELQDKVGA
Core:
A I P I T T S S W I C G V A S A A F C P S T A C T S K C
Core with dehydrations:
A I P I Dhb Dhb Dha Dha W I Cys G V A Dha A A F Cys P Dha Dhb A Cys Dhb Dha K Cys

#### antiSMASH-DB 4.0 matches for LDO05_RS02090

100.0%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide
Lanthipeptides: LDO05_RS02090_lanthipeptide
1
A I P I T T S S W I C G V A S A A F C P S T A C T S K C
28
A I P I T T S S W I C G V A S A A F C P S T A C T S K C
1
A I P I T T S S W I C G V A S A A F C P S T A C T S K C
28
64.5%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00150_lanthipeptide
Lanthipeptides: C8268_RS00150_lanthipeptide
1
A I P I T T S S W I C G V A S A A F C P S T A C T S K C
28
A+ I T T S S W I C G +A A C P S T A C T C
4
A L G I T T S S W I C G F V T A A L C P S T A C T G D C
31
53.1%
NZ_CP006058.1 and 25 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS19790_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptide NZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptide NZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide
Lanthipeptides: BAMY6639_RS19790_lanthipeptide
5
T T S S W I C G V-A S A A F C P S T A C T S K C
28
T S S C G V +A A F C P S T C T S C
8
T P S S L P C G V F V T A A F C P S T K C T S S C
32
with 102 more sequence matches
Only the first 10 are displayed here.
50.0%
NZ_CP013862.1 and 1 other:
NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide
Lanthipeptides: AOX59_RS09365_lanthipeptide
5
T T S S W I C G V A-S A A F C P S T A C T S K C
28
T S S C G+A S A F C P+T C T S+C
8
T P S S V A C G I A V S A L F C P T T K C T S Q C
32
50.0%
NZ_FOBE01000018.1:
Lanthipeptides: BMW61_RS21935_lanthipeptide
1
A I P I T T S S W I C G V A S A A F C P S T A C T S K C
28
+P I T I A S A F C P S C+S K C
5
G V P I T V P I T I--A A S T A F C P S I K C S S K C
30
46.4%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00390_lanthipeptide
Lanthipeptides: CWT12_RS00390_lanthipeptide
5
T T S S W I C G V A-S A A F C P S T A C T S K C
28
T S S W C G+ + C P+ A C+S K C
3
T P S S W P C G I G I T T T V C P T A A C S S K C
27
46.4%
NZ_CP039292.1 and 1 other:
NZ_CP039292.1 Lanthipeptides: E4J16_RS14990_lanthipeptide
Lanthipeptides: E4J16_RS14990_lanthipeptide
5
T T S S W I C G V A-S A A F C P S T A C T S K C
28
T S S W C G+ + C P+ C T S K C
3
T P S S W P C G I G I T T T I C P T A V C T S K C
27
46.4%
NZ_PCGR01000003.1 and 1 other:
NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide
Lanthipeptides: CQS04_RS09625_lanthipeptide
1
A I P I T T S S W I C G V A S A A F C P S T A C T S K C
28
A P + I G S A C P+T A C T C
1
A T P T I V I T A I T G Y I S A N S C P T T A C T R A C
28
44.7%
NC_006322.1 and 7 others:
NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide
Lanthipeptides: BLI_RS20290_lanthipeptide
3
P I T T S S W I C G V A----S A A F C P S T A C T S K C
28
P T T S S W C A S A+ C P+T C T S+C
9
P A T T S S W T C I T A G V T V S A S L C P T T K C T S R C
38
43.8%
NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00915_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide
Lanthipeptides: BALI_RS00915_lanthipeptide
5
T T S S W I C G-V A S A A F C P S T A C T S K C
28
T S S C G + +A +C P S A C T S C
8
T P S S L P C G T L V T A V W C P S N A C T S D C
32
43.6%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide
Lanthipeptides: P40081_RS37160_lanthipeptide
3
P I T T S S W I C G V A----S A A F C P S T A C T S K C
28
P+T T S S W C + S A C P+T C T S K C
10
P L T T S S W P C V I G A V D I S A N L C P T T K C T S K C
39
41.4%
NZ_CP040938.1 and 1 other:
NZ_CP040938.1 Lanthipeptides: B5772_RS02455_lanthipeptide
Lanthipeptides: B5772_RS02455_lanthipeptide
4
I T T S S W I C G V A S A A F C P S T A C T S K C
28
I T T S +A S A C P+ C++K C
1
I T T S I P C A V M A S T A I C P T L V C S N K C
25
41.4%
NZ_JABBGE010000004.1 and 1 other:
NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13570_lanthipeptide
Lanthipeptides: HHL19_RS13570_lanthipeptide
7
S S W I C G V A-------S A A F C P S T A C T S K C
28
++W C V S A+ C P+T C T S+C
1
T T W S C A V V T A V A T L V S A S A C P T T K C T S Q C
29

#### MIBiG 4.0 matches for LDO05_RS02090

32.1%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
18
F C P S T A C T S K C
28
F C P+T C T S K C
16
F C P T T K C T S K C
26
29.7%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
15
S A A F C P S T A C T S K C
28
S A A F C P+T C T S+C
24
S A A F C P T T K C T S R C
37
allorf_0460692_0460856
Leader:
MKVQVLILVKMISQASHIIPLYKYVLSKNLLEKKHRPAA
Core:
S R S C M A V L S H I L D A I
Core with dehydrations:
Dha R Dha Cys M A V L Dha H I L D A I

#### antiSMASH-DB 4.0 matches for allorf_0460692_0460856

100.0%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: allorf_0460692_0460856_lanthipeptide
Lanthipeptides: allorf_0460692_0460856_lanthipeptide
1
S R S C M A V L S H I L D A I
15
S R S C M A V L S H I L D A I
1
S R S C M A V L S H I L D A I
15
allorf_0461347_0461490
Leader:
MLKMKEVLSFLPIDLKEWSKAETWGLLQKSPGS
Core:
I P I S E S I C T P P D I L
Core with dehydrations:
I P I Dha E Dha I Cys Dhb P P D I L

#### antiSMASH-DB 4.0 matches for allorf_0461347_0461490

100.0%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: allorf_0461347_0461490_lanthipeptide
Lanthipeptides: allorf_0461347_0461490_lanthipeptide
1
I P I S E S I C T P P D I L
14
I P I S E S I C T P P D I L
1
I P I S E S I C T P P D I L
14
18.8%
NC_014479.1 and 9 others:
NZ_CP026362.1 Lanthipeptides: BV11031_RS00400_lanthipeptide NZ_CP033052.1 Lanthipeptides: D9779_RS17315_lanthipeptide NZ_CP051464.1 Lanthipeptides: HC660_RS17030_lanthipeptide NZ_JALAKK010000002.1 Lanthipeptides: MOB09_RS02800_lanthipeptide NZ_JALAKO010000014.1 Lanthipeptides: MOB26_RS08535_lanthipeptide NZ_JALAOG010000003.1 Lanthipeptides: MOC96_RS02500_lanthipeptide NZ_JALAPG010000043.1 Lanthipeptides: MOC70_RS16815_lanthipeptide NZ_JALAQI010000009.1 Lanthipeptides: MOD13_RS06065_lanthipeptide NZ_NXEM01000027.1 Lanthipeptides: CPT06_RS15285_lanthipeptide
Lanthipeptides: BSUW23_RS16845_lanthipeptide
4
S E S I C T P P D I
13
S E S+C T P +
3
S E S L C T P G C V
12
18.8%
NC_016047.1 and 6 others:
NZ_CP025079.1 Lanthipeptides: BVQ_RS17705_lanthipeptide NZ_CP047644.1 Lanthipeptides: GNE05_RS17275_lanthipeptide NZ_CP099859.1 Lanthipeptides: NIZ95_RS16280_lanthipeptide NZ_CP101621.1 Lanthipeptides: NN913_RS16115_lanthipeptide NZ_KZ848487.1 Lanthipeptides: DSL71_RS15965_lanthipeptide NZ_MUXL01000003.1 Lanthipeptides: B0W20_RS12275_lanthipeptide
Lanthipeptides: GYO_RS39160_lanthipeptide
4
S E S I C T P
10
S E S+C T P
3
S E S V C T P
9
with 3 more sequence matches
18.8%
NZ_CP021903.1 and 20 others:
NZ_CP023409.1 Lanthipeptides: Bateq7PJ16_RS18530_lanthipeptide NZ_CP026036.1 Lanthipeptides: C2H93_RS15000_lanthipeptide NZ_CP028218.1 Lanthipeptides: C7M30_RS14555_lanthipeptide NZ_CP035167.1 Lanthipeptides: EQJ08_RS17140_lanthipeptide NZ_CP035226.1 Lanthipeptides: EQW70_RS18175_lanthipeptide NZ_CP045006.1 Lanthipeptides: F9B13_RS03875_lanthipeptide NZ_CP076083.1 Lanthipeptides: KFF76_RS16710_lanthipeptide NZ_CP079759.1 Lanthipeptides: KXZ66_RS17780_lanthipeptide NZ_CP080508.1 Lanthipeptides: K0V03_RS06525_lanthipeptide NZ_CP089148.1 Lanthipeptides: LRO88_RS19055_lanthipeptide NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04985_lanthipeptide NZ_JALAVX010000009.1 Lanthipeptides: MOE40_RS09385_lanthipeptide NZ_JAMYDW010000007.1 Lanthipeptides: NHM07_RS16180_lanthipeptide NZ_JAQOXM010000001.1 Lanthipeptides: PO770_RS03875_lanthipeptide NZ_NJRD01000003.1 Lanthipeptides: CE053_RS07200_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18435_lanthipeptide NZ_SORJ01000001.1 Lanthipeptides: BJ795_RS01490_lanthipeptide NZ_VFNF01000001.1 Lanthipeptides: FB592_RS01525_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03850_lanthipeptide NZ_VLJL01000012.1 Lanthipeptides: L604_RS09425_lanthipeptide
Lanthipeptides: CD007_RS17065_lanthipeptide
4
S E S I C T P
10
S E S+C T P
3
S E S L C T P
9
18.8%
NZ_JAMDIB010000004.1:
Lanthipeptides: M5P35_RS04030_lanthipeptide
4
S E S I C T P P D
12
S+S+C T P P
3
S K S L C T P P G
11
13.7%
NZ_JADMPO010000001.1:
Lanthipeptides: allorf_303731_303931_lanthipeptide
1
I P I S E S I C T P P
11
I P I S C+P P
8
I P I S N L F C S P P
18
allorf_0463481_0463591
Leader:
MRLKSPFCIIIFYFFIIINYTLHGS
Core:
S C K Y W I A S L L P
Core with dehydrations:
Dha Cys K Y W I A Dha L L P

#### antiSMASH-DB 4.0 matches for allorf_0463481_0463591

100.0%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: allorf_0463481_0463591_lanthipeptide
Lanthipeptides: allorf_0463481_0463591_lanthipeptide
1
S C K Y W I A S L L P
11
S C K Y W I A S L L P
1
S C K Y W I A S L L P
11
14.3%
NZ_ML219773.1:
Lanthipeptides: allorf_1335288_1335458_lanthipeptide
3
K Y W I A S L L P
11
+Y W+ L+P
13
R Y W V D R L V P
21
12.1%
NZ_MKZS01000001.1:
Lanthipeptides: allorf_3081872_3082018_lanthipeptide
4
Y W I A S L L P
11
+W I+ +L P
20
F W I S D M L P
27

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 26.33 out of 26.33
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.96 out of 20.97
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.67 out of 28.19
Confidence: medium
Additional weak hits (5):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.86 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.35 out of 28.14
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.45 out of 21.55
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.30 out of 36.54
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

LDO05_RS02075 - Class II
  Cleavage pHMM score: -3.80
  RODEO score: 0
  Monoisotopic mass: 3184.4 Da
  Molecular weight: 3186.5 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3204.5 Da N = 1
    3222.5 Da N = 2
    3240.6 Da N = 3
    3258.6 Da N = 4
LDO05_RS02090 - Class II
  Cleavage pHMM score: -1.60
  RODEO score: 0
  Monoisotopic mass: 2613.3 Da
  Molecular weight: 2615.0 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2633.1 Da N = 1
    2651.1 Da N = 2
    2669.1 Da N = 3
    2687.1 Da N = 4
    2705.1 Da N = 5
allorf_0460692_0460856 - Class II
  Cleavage pHMM score: -6.90
  RODEO score: 0
  Monoisotopic mass: 1560.8 Da
  Molecular weight: 1561.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1579.9 Da N = 1
    1597.9 Da N = 2
allorf_0461347_0461490 - Class II
  Cleavage pHMM score: -6.00
  RODEO score: 0
  Monoisotopic mass: 1442.8 Da
  Molecular weight: 1443.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1461.7 Da N = 1
    1479.7 Da N = 2
allorf_0463481_0463591 - Class II
  Cleavage pHMM score: -5.60
  RODEO score: 0
  Monoisotopic mass: 1243.7 Da
  Molecular weight: 1244.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1262.5 Da N = 1
LDO05_RS02075 - Class II
  Cleavage pHMM score: -3.80
  RODEO score: 0
  Monoisotopic mass: 3184.4 Da
  Molecular weight: 3186.5 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3204.5 Da N = 1
    3222.5 Da N = 2
    3240.6 Da N = 3
    3258.6 Da N = 4
LDO05_RS02090 - Class II
  Cleavage pHMM score: -1.60
  RODEO score: 0
  Monoisotopic mass: 2613.3 Da
  Molecular weight: 2615.0 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2633.1 Da N = 1
    2651.1 Da N = 2
    2669.1 Da N = 3
    2687.1 Da N = 4
    2705.1 Da N = 5
allorf_0460692_0460856 - Class II
  Cleavage pHMM score: -6.90
  RODEO score: 0
  Monoisotopic mass: 1560.8 Da
  Molecular weight: 1561.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1579.9 Da N = 1
    1597.9 Da N = 2
allorf_0461347_0461490 - Class II
  Cleavage pHMM score: -6.00
  RODEO score: 0
  Monoisotopic mass: 1442.8 Da
  Molecular weight: 1443.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1461.7 Da N = 1
    1479.7 Da N = 2
allorf_0463481_0463591 - Class II
  Cleavage pHMM score: -5.60
  RODEO score: 0
  Monoisotopic mass: 1243.7 Da
  Molecular weight: 1244.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1262.5 Da N = 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CcpA | Catabolite control protein A
ZuR variant 1 | Zinc-responsive repressor

NZ_CP084530.1 - Region 4 - proteusin
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 884,917 - 905,156 nt. (total: 20,240 nt) Show pHMM detection rules used
proteusin: (PoyD or TIGR03793)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: glucosidase
LDO05_RS04060: Alpha-glucosidase

smcogs
  SMCOG1257: Alpha-glucosidase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | proteusin | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002285.2 |  | 0.44 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0001810.3 |  | 0.36 | PKS | trehangelin | Polymorphospora rubra
BGC0001735.5 |  | 0.30 | other (other) | pentostatine, vidarabine | Streptomyces antibioticus
BGC0000905.5 |  | 0.29 | other (other) | heme D1 | Heliobacillus mobilis
BGC0002571.2 |  | 0.29 | NRPS | pyoverdine DC3000 | Pseudomonas syringae pv. tomato str. DC3000
BGC0002122.2 |  | 0.25 | NRPS | gramicidin S | Aneurinibacillus migulanus
BGC0000804.5 |  | 0.25 | saccharide | acarviostatin I03, acarviostatin II03, acarviostatin III03, acarviostatin IV03 | Streptomyces coelicoflavus ZG0656
BGC0001728.4 |  | 0.24 | NRPS, PKS | paenilipoheptin | Paenibacillus polymyxa E681
BGC0001011.5 |  | 0.23 | NRPS, PKS | meridamycin | Streptomyces sp. NRRL 30748
BGC0001812.3 |  | 0.22 | PKS | tylactone | Micromonospora chalcea subsp. izumensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002285.2 |  | 0.44 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0001810.3 |  | 0.36 | PKS | trehangelin | Polymorphospora rubra
BGC0001735.5 |  | 0.30 | other (other) | pentostatine, vidarabine | Streptomyces antibioticus
BGC0000905.5 |  | 0.29 | other (other) | heme D1 | Heliobacillus mobilis
BGC0002571.2 |  | 0.29 | NRPS | pyoverdine DC3000 | Pseudomonas syringae pv. tomato str. DC3000
BGC0002122.2 |  | 0.25 | NRPS | gramicidin S | Aneurinibacillus migulanus
BGC0000804.5 |  | 0.25 | saccharide | acarviostatin I03, acarviostatin II03, acarviostatin III03, acarviostatin IV03 | Streptomyces coelicoflavus ZG0656
BGC0001728.4 |  | 0.24 | NRPS, PKS | paenilipoheptin | Paenibacillus polymyxa E681
BGC0001011.5 |  | 0.23 | NRPS, PKS | meridamycin | Streptomyces sp. NRRL 30748
BGC0001812.3 |  | 0.22 | PKS | tylactone | Micromonospora chalcea subsp. izumensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.05 out of 20.97
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.81 out of 27.78
Confidence: medium
Additional weak hits (5):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.98 out of 28.14
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.88 out of 39.62
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.73 out of 36.54
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.30 out of 26.06
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.40 out of 35.63
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_CP084530.1 - Region 5 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,704,292 - 1,725,167 nt. (total: 20,876 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
LDO05_RS07945: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
LDO05_RS07985: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

LDO05_RS07990: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002219.2 |  | 0.39 | terpene | (-)-(R)-nephthenol | Stereum hirsutum FP-91666 SS1
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0001594.3 |  | 0.37 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000666.5 |  | 0.36 | terpene | xiamycin A | Streptomyces sp. SCSIO 02999

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002219.2 |  | 0.39 | terpene | (-)-(R)-nephthenol | Stereum hirsutum FP-91666 SS1
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0001594.3 |  | 0.37 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000666.5 |  | 0.36 | terpene | xiamycin A | Streptomyces sp. SCSIO 02999

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
LDO05_RS07985: PT_FPPS_like
Domain 1 (26 - 291): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 20.49 out of 23.43
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.84 out of 27.78
Confidence: medium
Additional weak hits (6):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.37 out of 31.73
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.13 out of 30.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.37 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.98 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.16 out of 26.06
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.10 out of 35.63
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
BldD | Development and antibiotic global regulator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT | Regulator of MSHA biosynthesis

NZ_CP084530.1 - Region 6 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,993,010 - 2,024,674 nt. (total: 31,665 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
LDO05_RS09510: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

Hydrolases: deacetylase deaminase
LDO05_RS09445: ornithine cyclodeaminase

smcogs
  SMCOG1158: ornithine cyclodeaminase

LDO05_RS09495: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Lyases: decarboxylase
LDO05_RS09465: diaminopimelate decarboxylase

smcogs
  SMCOG1264: diaminopimelate decarboxylase

Ligases: synthase
LDO05_RS09440: cysteine synthase

smcogs
  SMCOG1081: cysteine synthase

LDO05_RS09485: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000943.5 |  | 0.60 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000946.5 |  | 0.59 | other (other) | vibrioferrin | Vibrio parahaemolyticus
BGC0001408.5 |  | 0.57 | other (other) | xanthoferrin | Xanthomonas oryzae pv. oryzae KACC 10331
BGC0002527.2 |  | 0.57 | other (other) | vibrioferrin | Azotobacter vinelandii CA
BGC0000942.4 |  | 0.56 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0001498.5 |  | 0.54 | other (other) | aerobactin | Xenorhabdus szentirmaii DSM 16338
BGC0002692.2 |  | 0.53 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0001870.3 |  | 0.52 | other (other) | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0001572.3 |  | 0.52 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0000939.5 |  | 0.51 | other (other) | aerobactin | Grimontia hollisae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000943.5 |  | 0.60 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000946.5 |  | 0.59 | other (other) | vibrioferrin | Vibrio parahaemolyticus
BGC0001408.5 |  | 0.57 | other (other) | xanthoferrin | Xanthomonas oryzae pv. oryzae KACC 10331
BGC0002527.2 |  | 0.57 | other (other) | vibrioferrin | Azotobacter vinelandii CA
BGC0000942.4 |  | 0.56 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0001498.5 |  | 0.54 | other (other) | aerobactin | Xenorhabdus szentirmaii DSM 16338
BGC0002692.2 |  | 0.53 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0001870.3 |  | 0.52 | other (other) | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0001572.3 |  | 0.52 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0000939.5 |  | 0.51 | other (other) | aerobactin | Grimontia hollisae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.37 out of 29.38
Confidence: strong
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.00 out of 20.47
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.34 out of 29.38
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.10 out of 26.06
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19
Confidence: medium
Additional weak hits (12):
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.61 out of 32.74
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.12 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.97 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.36 out of 29.38
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.27 out of 32.93
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.58 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.72 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.83 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.48 out of 28.14
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.07 out of 30.97
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
VqsM | Regulator of quorum-sensing signalling systems
ZuR variant 1 | Zinc-responsive repressor

NZ_CP084530.1 - Region 7 - T3PKS,other
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,097,249 - 2,156,641 nt. (total: 59,393 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
other: (Neocarzinostat or bcpB or frbD or mitE or prnB or CaiA or bacilysin or orf2_PTase)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
LDO05_RS09945: oxidoreductase

smcogs
  SMCOG1161: oxidoreductase

LDO05_RS10075: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

Transferases: aminotransferase
LDO05_RS10095: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs
  SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

LDO05_RS10100: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs
  SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

LDO05_RS10135: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: deacetylase hydrolase
LDO05_RS09900: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

LDO05_RS10015: HAD-superfamily hydrolase, subfamily IA, variant

smcogs
  SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

LDO05_RS10020: alpha/beta hydrolase fold protein

smcogs
  SMCOG1036: alpha/beta hydrolase fold protein

LDO05_RS10085: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

Lyases: lyase
LDO05_RS10045: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

LDO05_RS10050: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: synthase
LDO05_RS09955: chalcone and stilbene synthase domain protein

smcogs
  SMCOG1024: chalcone and stilbene synthase domain protein

LDO05_RS10120: cysteine synthase

smcogs
  SMCOG1081: cysteine synthase

Translocases: permease
LDO05_RS09940: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | other | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001310.5 |  |  | 0.42 | PKS | naringenin | Streptomyces clavuligerus ATCC 27064
BGC0002332.2 |  |  | 0.36 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0000387.5 |  |  | 0.35 | NRPS | mangotoxin | Pseudomonas syringae pv. syringae
BGC0000888.5 |  |  | 0.31 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001184.4 |  |  | 0.30 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0002573.2 |  |  | 0.29 | other (other) | phosphoramidon | Streptomyces mozunensis
BGC0001077.4 |  |  | 0.29 | PKS | 6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone | Actinoplanes missouriensis 431
BGC0002362.3 |  |  | 0.27 | PKS | loseolamycin A1, loseolamycin A2 | Micromonospora endolithica
BGC0000563.4 |  |  | 0.26 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001590.5 |  |  | 0.26 | PKS | formicamycin A, formicamycin B, formicamycin C, formicamycin D, formicamycin E, formicamycin F, formicamycin G, formicamycin H, formicamycin I, formicamycin J, formicamycin K, formicamycin L, formicamycin M, fasamycin C, fasamycin D, fasamycin E | Streptomyces sp. KY5

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001310.5 |  | 0.53 | PKS | naringenin | Streptomyces clavuligerus ATCC 27064
BGC0002332.2 |  | 0.49 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0000387.5 |  | 0.49 | NRPS | mangotoxin | Pseudomonas syringae pv. syringae
BGC0000898.5 |  | 0.47 | saccharide | desosamine, pikromycin, neomethymycin, narbomycin | Streptomyces venezuelae
BGC0002568.2 |  | 0.47 | other (other) | Ethylenediaminesuccinic acid hydroxyarginine | Streptomyces scabiei 87.22
BGC0001184.4 |  | 0.46 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0002487.3 |  | 0.46 | other (other) | staphylopine | Staphylococcus aureus subsp. aureus Mu50
BGC0000899.4 |  | 0.46 | saccharide | desosamine | Streptomyces narbonensis
BGC0002567.2 |  | 0.46 | other (other) | EDHA | Streptomyces sp. MA5143a
BGC0001595.3 |  | 0.46 | other (other) | fischerindole | Fischerella sp. SAG 46.79

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.48 out of 18.57
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.97 out of 21.55
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.06 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.54 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.32 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.00 out of 28.19
Confidence: medium
Additional weak hits (13):
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.57 out of 33.73
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.57 out of 36.53
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.91 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.70 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.47 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.96 out of 29.38
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.38 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.26 out of 26.06
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.12 out of 32.74
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.70 out of 27.04
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.28 out of 31.73
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.24 out of 33.14
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.64 out of 32.93
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP084530.1 - Region 8 - opine-like-metallophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,185,600 - 2,207,740 nt. (total: 22,141 nt) Show pHMM detection rules used
opine-like-metallophore: (CntL and CntM)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | opine-like-metallophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002488.3 |  | 0.82 | other (other) | bacillopaline | Paenibacillus mucilaginosus KNP414
BGC0002487.3 |  | 0.79 | other (other) | staphylopine | Staphylococcus aureus subsp. aureus Mu50
BGC0002489.2 |  | 0.53 | other (other) | pseudopaline | Pseudomonas aeruginosa PAO1
BGC0002490.2 |  | 0.50 | other (other) | yersinopine | Yersinia pestis CO92
BGC0000513.3 |  | 0.41 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000551.5 |  | 0.41 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000501.3 |  | 0.40 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002698.2 |  | 0.39 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000546.3 |  | 0.39 | ribosomal | SAL-2242 | Streptomyces albidoflavus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002488.3 |  | 0.82 | other (other) | bacillopaline | Paenibacillus mucilaginosus KNP414
BGC0002487.3 |  | 0.79 | other (other) | staphylopine | Staphylococcus aureus subsp. aureus Mu50
BGC0002489.2 |  | 0.53 | other (other) | pseudopaline | Pseudomonas aeruginosa PAO1
BGC0002490.2 |  | 0.50 | other (other) | yersinopine | Yersinia pestis CO92
BGC0000513.3 |  | 0.41 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000551.5 |  | 0.41 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000501.3 |  | 0.40 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002698.2 |  | 0.39 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000546.3 |  | 0.39 | ribosomal | SAL-2242 | Streptomyces albidoflavus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.28 out of 26.06
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16
Confidence: strong
Additional weak hits (2):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.48 out of 26.06
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.33 out of 35.63
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
MogR | Repressor of flagellar motility genes

NZ_CP084530.1 - Region 9 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,638,869 - 2,659,399 nt. (total: 20,531 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Translocases: transport
LDO05_RS12465: MMPL domain-containing transport protein

smcogs
  SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000779.3 |  | 0.35 | saccharide | lipopolysaccharide | Aeromonas piscicola
BGC0000679.5 |  | 0.24 | terpene | diazepinomicin | Micromonospora sp. M42
BGC0001330.5 |  | 0.23 | NRPS, PKS | BE-43547A1, BE-43547A2, BE-43547B1, BE-43547B2, BE-43547B3, BE-43547C1, BE-43547C2 | Micromonospora sp. RV43
BGC0002381.3 |  | 0.23 | PKS, other (other) | tambjamine BE-18591 | Streptomyces albus subsp. albus
BGC0000982.5 |  | 0.23 | NRPS, PKS | cystothiazole A | Cystobacter fuscus
BGC0001848.4 |  | 0.22 | other (other) | diazaquinomycin H, diazaquinomycin J | Micromonospora sp. B006
BGC0000203.3 |  | 0.21 | PKS | BE-7585A | Amycolatopsis orientalis subsp. vinearia
BGC0000780.3 |  | 0.19 | saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0000965.5 |  | 0.18 | PKS | C-1027 | Streptomyces globisporus
BGC0001397.5 |  | 0.18 | NRPS, PKS | lidamycin | Streptomyces globisporus C-1027

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000779.3 |  | 0.35 | saccharide | lipopolysaccharide | Aeromonas piscicola
BGC0000679.5 |  | 0.24 | terpene | diazepinomicin | Micromonospora sp. M42
BGC0001330.5 |  | 0.23 | NRPS, PKS | BE-43547A1, BE-43547A2, BE-43547B1, BE-43547B2, BE-43547B3, BE-43547C1, BE-43547C2 | Micromonospora sp. RV43
BGC0002381.3 |  | 0.23 | PKS, other (other) | tambjamine BE-18591 | Streptomyces albus subsp. albus
BGC0000982.5 |  | 0.23 | NRPS, PKS | cystothiazole A | Cystobacter fuscus
BGC0001848.4 |  | 0.22 | other (other) | diazaquinomycin H, diazaquinomycin J | Micromonospora sp. B006
BGC0000203.3 |  | 0.21 | PKS | BE-7585A | Amycolatopsis orientalis subsp. vinearia
BGC0000780.3 |  | 0.19 | saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0000965.5 |  | 0.18 | PKS | C-1027 | Streptomyces globisporus
BGC0001397.5 |  | 0.18 | NRPS, PKS | lidamycin | Streptomyces globisporus C-1027

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.21 out of 27.78
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.51 out of 23.79
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.90 out of 24.78
Confidence: strong
Additional weak hits (1):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.71 out of 30.25
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
IolR | Regulator of the inositol catabolism
LexA variant 2 | Repressor of DNA damage response
ToxT | Regulator of MSHA biosynthesis

NZ_CP084530.1 - Region 10 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,549,555 - 3,570,478 nt. (total: 20,924 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
LDO05_RS16845: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

LDO05_RS16870: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

LDO05_RS16875: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

Ligases: synthase
LDO05_RS16850: polyprenol-monophosphomannose synthase ppm1

smcogs
  SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000645.3 |  | 0.65 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000656.5 |  | 0.58 | terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000647.3 |  | 0.58 | terpene | carotenoid | Rhodobacter sphaeroides
BGC0000664.5 |  | 0.50 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3 |  | 0.49 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000640.3 |  | 0.45 | terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000642.3 |  | 0.44 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000633.3 |  | 0.43 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.43 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000635.3 |  | 0.42 | terpene | carotenoid | Paracoccus sp. N81106

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000645.3 |  | 0.65 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000656.5 |  | 0.58 | terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000647.3 |  | 0.58 | terpene | carotenoid | Rhodobacter sphaeroides
BGC0000664.5 |  | 0.50 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3 |  | 0.49 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000640.3 |  | 0.45 | terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000642.3 |  | 0.44 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000633.3 |  | 0.43 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.43 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000635.3 |  | 0.42 | terpene | carotenoid | Paracoccus sp. N81106

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene |  | squalene | C30 | acyclic | none
triterpene |  | PSPP | C30 | acyclic | PP
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none
tetraterpene | C40 carotenoid | phytoene | C40 | acyclic | none
triterpene |  | hydroxysqualene | C30 | acyclic | OH

Genes with terpene domains:
LDO05_RS16865: PT_phytoene_like
Domain 1 (6 - 279): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → squalene
  FPP → PSPP
  FPP → diapophytoene
  GGPP → phytoene
  PSPP → hydroxysqualene

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.69 out of 26.85
Confidence: medium
Additional weak hits (6):
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.62 out of 29.25
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.73 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.81 out of 26.06
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.36 out of 21.55
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.50 out of 20.01
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.20 out of 26.06
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
PP | Diphosphate
PSPP | Presqualene diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
RutR | Regulator of the pyrimidine and purine metabolism