GCF_023699965.1 - 14 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP077072.1 (Luteibacter anthropi)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	redox-cofactor	76,912	99,056
Region 2	terpene-precursor	397,041	417,943
Region 3	RiPP-like	1,135,499	1,146,335
Region 4	lanthipeptide-class-iii	1,332,088	1,354,808
Region 5	arylpolyene	1,817,048	1,858,238	Low	xanthomonadin I	other:other
Region 6	RiPP-like	2,138,152	2,151,448
Region 7	lanthipeptide-class-ii	2,267,382	2,290,318
Region 8	lanthipeptide-class-ii	2,536,572	2,559,448
Region 9	NRPS	2,825,728	2,897,422	High	rhizomide A/rhizomide B/rhizomide C	NRPS:Type I
Region 10	NRPS,T1PKS	3,682,473	3,735,023
Region 11	NI-siderophore	3,880,425	3,913,098	High	xanthoferrin	other:other
Region 12	NRP-metallophore,NRPS	4,117,764	4,182,637	Low	pyochelin	NRPS:Type I
Region 13	T1PKS	4,502,945	4,548,698
Region 14	lanthipeptide-class-ii	4,753,378	4,776,317

NZ_CP077072.1 - Region 1 - redox-cofactor

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Location: 76,912 - 99,056 nt. (total: 22,145 nt) Show pHMM detection rules used

redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001485.4	0.40	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0001100.5	0.34	NRPS, PKS	lankacidin C	Streptomyces rochei
BGC0001440.5	0.34	other (other)	cystargolide A, cystargolide B	Kitasatospora cystarginea
BGC0002138.2	0.32	PKS	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670
BGC0001441.5	0.32	other (other)	belactosin A, belactosin C	Streptomyces sp.
BGC0002060.3	0.29	PKS	secimide	Pseudomonas syringae pv. syringae B728a
BGC0002496.3	0.28	NRPS	serratiochelin A, serratiochelin C, serratiochelin B	Serratia plymuthica
BGC0001019.5	0.27	NRPS, PKS	microsclerodermin M	Sorangium cellulosum
BGC0002359.3	0.26	NRPS	dudomycin A	Streptomyces albus subsp. chlorinus
BGC0002282.2	0.26	other (other)	formycin A	Streptomyces kaniharaensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001485.4	0.40	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0001100.5	0.34	NRPS, PKS	lankacidin C	Streptomyces rochei
BGC0001440.5	0.34	other (other)	cystargolide A, cystargolide B	Kitasatospora cystarginea
BGC0002138.2	0.32	PKS	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670
BGC0001441.5	0.32	other (other)	belactosin A, belactosin C	Streptomyces sp.
BGC0002060.3	0.29	PKS	secimide	Pseudomonas syringae pv. syringae B728a
BGC0002496.3	0.28	NRPS	serratiochelin A, serratiochelin C, serratiochelin B	Serratia plymuthica
BGC0001019.5	0.27	NRPS, PKS	microsclerodermin M	Sorangium cellulosum
BGC0002359.3	0.26	NRPS	dudomycin A	Streptomyces albus subsp. chlorinus
BGC0002282.2	0.26	other (other)	formycin A	Streptomyces kaniharaensis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.31 out of 18.46

Confidence: strong

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 26.42 out of 29.72

Confidence: strong

Additional weak hits (3):

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.35 out of 36.53

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.86 out of 23.43

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.03 out of 29.65

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: PqqD_RRE; Location: 0 - 86; Score: 111.3

TFBS definitions

Regulator	Description
NtrC	Nitrogen regulatory protein C
RpoN	Regulator of nitrogen assimilation and virulence

NZ_CP077072.1 - Region 2 - terpene-precursor

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Location: 397,041 - 417,943 nt. (total: 20,903 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

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MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: transferase

KR767_RS01850: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Ligases: synthetase

KR767_RS01880: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000630.3	0.36	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000646.5	0.35	terpene	β-carotein	uncultured bacterium
BGC0000641.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000639.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.34	terpene	carotenoid	Pantoea ananatis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000630.3	0.36	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000646.5	0.35	terpene	β-carotein	uncultured bacterium
BGC0000641.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000639.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.34	terpene	carotenoid	Pantoea ananatis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

KR767_RS01880: PT_FPPS_like

Domain 1 (36 - 298): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.76 out of 27.55

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.16 out of 26.33

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.95 out of 20.97

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52

Confidence: strong

Additional weak hits (3):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.96 out of 26.33

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.11 out of 25.75

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.21 out of 28.19

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
AbrC3	Antibiotic production activator
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CcpA	Catabolite control protein A
GnfM	Regulator of nitrogen-fixation genes

NZ_CP077072.1 - Region 3 - RiPP-like

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Location: 1,135,499 - 1,146,335 nt. (total: 10,837 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002133.3	0.43	ribosomal	group 1 methanobactin	Methylosinus sp. LW3
BGC0000527.5	0.39	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000043.5	0.39	PKS	curacin A	Moorea producens 19L
BGC0000589.5	0.39	ribosomal	microcin M	Escherichia coli Nissle 1917
BGC0002116.3	0.38	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0002571.2	0.38	NRPS	pyoverdine DC3000	Pseudomonas syringae pv. tomato str. DC3000
BGC0002447.3	0.37	ribosomal	cerecyclin	Bacillus cereus
BGC0002442.3	0.36	ribosomal	toyoncin	Bacillus toyonensis
BGC0000487.5	0.36	ribosomal	carnocyclin	Carnobacterium maltaromaticum
BGC0001727.3	0.36	ribosomal	paenilan	Paenibacillus polymyxa E681

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002133.3	0.43	ribosomal	group 1 methanobactin	Methylosinus sp. LW3
BGC0000527.5	0.39	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000043.5	0.39	PKS	curacin A	Moorea producens 19L
BGC0000589.5	0.39	ribosomal	microcin M	Escherichia coli Nissle 1917
BGC0002116.3	0.38	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0002571.2	0.38	NRPS	pyoverdine DC3000	Pseudomonas syringae pv. tomato str. DC3000
BGC0002447.3	0.37	ribosomal	cerecyclin	Bacillus cereus
BGC0002442.3	0.36	ribosomal	toyoncin	Bacillus toyonensis
BGC0000487.5	0.36	ribosomal	carnocyclin	Carnobacterium maltaromaticum
BGC0001727.3	0.36	ribosomal	paenilan	Paenibacillus polymyxa E681

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.15 out of 27.55

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.08 out of 28.19

Confidence: medium

TFBS Finder

TFBS definitions

Regulator	Description
GnfM	Regulator of nitrogen-fixation genes
ZuR variant 1	Zinc-responsive repressor

NZ_CP077072.1 - Region 4 - lanthipeptide-class-iii

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Location: 1,332,088 - 1,354,808 nt. (total: 22,721 nt) Show pHMM detection rules used

lanthipeptide-class-iii: (micKC and not PKS_KS)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Isomerases: mutase

KR767_RS06100: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002337.2	0.56	ribosomal	class IV lanthipeptide, SflA	Streptomyces sp. NRRL S-1022
BGC0002700.2	0.51	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000519.4	0.51	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000496.5	0.51	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000513.3	0.49	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000553.3	0.48	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0002111.3	0.48	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0002701.2	0.40	ribosomal	paenithipeptin	Paenibacillus thiaminolyticus
BGC0002116.3	0.38	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0002447.3	0.37	ribosomal	cerecyclin	Bacillus cereus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002337.2	0.56	ribosomal	class IV lanthipeptide, SflA	Streptomyces sp. NRRL S-1022
BGC0002700.2	0.51	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000519.4	0.51	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000496.5	0.51	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000513.3	0.49	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000553.3	0.48	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0002111.3	0.48	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0002701.2	0.40	ribosomal	paenithipeptin	Paenibacillus thiaminolyticus
BGC0002116.3	0.38	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0002447.3	0.37	ribosomal	cerecyclin	Bacillus cereus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46

Confidence: strong

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.64 out of 27.55

Confidence: medium

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 22.05 out of 22.40

Confidence: strong

Additional weak hits (7):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.21 out of 26.33

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.57 out of 26.33

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.52 out of 18.57

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.81 out of 21.55

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.76 out of 30.25

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.31 out of 27.78

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.85 out of 20.01

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

No core peptides found.

TFBS definitions

Regulator	Description
GnfM	Regulator of nitrogen-fixation genes
HypR	L-hydroxyproline utilization repressor
RpoN	Regulator of nitrogen assimilation and virulence

NZ_CP077072.1 - Region 5 - arylpolyene

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Location: 1,817,048 - 1,858,238 nt. (total: 41,191 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: transferase

KR767_RS08185: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Hydrolases: peptidase

KR767_RS08280: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Isomerases: mutase

KR767_RS08255: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Ligases: synthase

KR767_RS08225: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

KR767_RS08235: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001160.5	0.55	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.54	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001217.5	0.50	other (other)	PreQ0 Base	Streptomyces qinglanensis
BGC0000840.5	0.49	other (other)	xanthomonadin I	Xanthomonas oryzae pv. oryzae
BGC0000013.3	0.43	PKS	alternariol	Aspergillus nidulans FGSC A4
BGC0002008.3	0.43	other (other)	aryl polyenes	Xenorhabdus doucetiae
BGC0001400.3	0.43	PKS	citreoviridin	Aspergillus terreus NIH2624
BGC0000836.5	0.43	other (other)	APE Ec	Escherichia coli CFT073
BGC0001987.2	0.42	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0000837.4	0.40	other (other)	APE Vf	Aliivibrio fischeri ES114

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001160.5	0.55	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.54	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001217.5	0.50	other (other)	PreQ0 Base	Streptomyces qinglanensis
BGC0000840.5	0.49	other (other)	xanthomonadin I	Xanthomonas oryzae pv. oryzae
BGC0000013.3	0.43	PKS	alternariol	Aspergillus nidulans FGSC A4
BGC0002008.3	0.43	other (other)	aryl polyenes	Xenorhabdus doucetiae
BGC0001400.3	0.43	PKS	citreoviridin	Aspergillus terreus NIH2624
BGC0000836.5	0.43	other (other)	APE Ec	Escherichia coli CFT073
BGC0001987.2	0.42	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0000837.4	0.40	other (other)	APE Vf	Aliivibrio fischeri ES114

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.99 out of 20.47

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.60 out of 23.79

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.38 out of 23.79

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.21 out of 23.79

Confidence: medium

Additional weak hits (10):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.46 out of 27.55

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 18.63 out of 30.97

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.82 out of 32.93

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.07 out of 29.65

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.79 out of 22.40

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.12 out of 21.84

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 23.42 out of 32.38

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.50 out of 32.93

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.06 out of 26.06

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 18.90 out of 33.14

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
IolR	Regulator of the inositol catabolism
VqsM	Regulator of quorum-sensing signalling systems

NZ_CP077072.1 - Region 6 - RiPP-like

Download region GenBank file

Download region SVG

Location: 2,138,152 - 2,151,448 nt. (total: 13,297 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	RiPP-like	Similarity score	Type	Compound(s)	Organism
BGC0001285.5		0.26	other (fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0002788.2		0.20	PKS	14-hydroxyisochainin	Streptomyces peucetius subsp. caesius ATCC 27952

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0001285.5		0.26	other (fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0002788.2		0.20	PKS	14-hydroxyisochainin	Streptomyces peucetius subsp. caesius ATCC 27952

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.79 out of 21.84

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

Additional weak hits (5):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 20.79 out of 30.97

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.94 out of 19.52

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.77 out of 27.55

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.33 out of 27.04

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.50 out of 30.98

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CRP	Cyclic AMP receptor protein
MexT	Global virulence regulator

NZ_CP077072.1 - Region 7 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 2,267,382 - 2,290,318 nt. (total: 22,937 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: dehalogenase

KR767_RS10115: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

Lyases: cyclase

KR767_RS10080: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001579.4	0.49	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000528.5	0.48	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002698.2	0.46	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000503.5	0.45	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0002346.3	0.43	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000527.5	0.42	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000517.4	0.41	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001364.3	0.39	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0001863.4	0.38	ribosomal, terpene	bacillicn CER074	Bacillus mycoides

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001579.4	0.49	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000528.5	0.48	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002698.2	0.46	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000503.5	0.45	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0002346.3	0.43	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000527.5	0.42	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000517.4	0.41	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001364.3	0.39	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0001863.4	0.38	ribosomal, terpene	bacillicn CER074	Bacillus mycoides

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for KR767_RS10080

KR767_RS10085

Leader:

MQTDKILAGWLSGADSVGG

Core:

YDNPAGSLYTEGLAKTMNAMTNPEVAIGTNCSSCTASRPGFCC

Core with dehydrations:

YDNPAGDhaLYDhbEGLAKDhbMNAMDhbNPEVAIGDhbNCysDhaDhaCysDhbADhaRPGFCysCys

antiSMASH-DB 4.0 matches for KR767_RS10085

100.0%

NZ_CP077072.1:

Lanthipeptides: KR767_RS10085_lanthipeptide

1

YDNPAGSLYTEGLAKTMNAMTNPEVAIGTNCSSCTASRPGFCC

43

YDNPAGSLYTEGLAKTMNAMTNPEVAIGTNCSSCTASRPGFCC

1

YDNPAGSLYTEGLAKTMNAMTNPEVAIGTNCSSCTASRPGFCC

43

79.1%

NZ_CP095741.1:

Lanthipeptides: L2Y96_RS03630_lanthipeptide

1

YDNPAGSLYTEGLAKTMNAMTNPEVAIGTNCSSCTASRPGFCC

43

YDNPAGSLYTEG A+TM AMTN E+A+ +NCSSCTASRPG CC

1

YDNPAGSLYTEGQAQTMVAMTNAEMALASNCSSCTASRPGLCC

43

74.4%

NZ_CP095742.1:

Lanthipeptides: L2Y97_RS03060_lanthipeptide

1

YDNPAGSLYTEGLAKTMNAMTNPEVAIGTNCSSCTASRPGFCC

43

YDNPAGSLYTEG +TM AM N E+A+ +NCSSCTASRPG CC

1

YDNPAGSLYTEGQTQTMAAMVNAEMALASNCSSCTASRPGLCC

43

with 61 more sequence matches

Only the first 10 are displayed here.

72.1%

NZ_JAAOYX010000001.1:

Lanthipeptides: FHS47_RS11835_lanthipeptide

1

YDNPAGSLYTEGLAKTMNAMTNPEVAIGTNCSSCTASRPGFCC

43

YDNPAGSLYTEG A+T+ AMT+ ++A+ +NCSSCTASRPG CC

1

YDNPAGSLYTEGHAQTVMAMTSTDIALVSNCSSCTASRPGVCC

43

54.7%

NZ_CP063231.1and 1 other:

NZ_FPIS01000001.1 Lanthipeptides: BT115_RS02490_lanthipeptide

Lanthipeptides: IM816_RS09045_lanthipeptide

1

YDNPAGSLYTEGLAKTMNAMTNPEVAIGTNCSSCTASRPGFCC

43

YDNPAG LYTEG +T+ AMT+ ++A+ +NCSSCTASRPG CC

11

YDNPAGPLYTEGHNQTLMAMTSTDIALISNCSSCTASRPGVCC

53

48.8%

NZ_CP010407.1and 4 others:

NZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptideNZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptideNZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptideNZ_JACHJY010000017.1 Lanthipeptides: GGE06_RS39715_lanthipeptide

Lanthipeptides: SVTN_RS37515_lanthipeptide

2

DNPAGSLYTEGLAKTMNAMTNPEVAIGTNCSSCTASRPGFCC

43

DNPAG LY G A A+T+ A+ T CSSCT S +CC

1

DNPAGPLYVGGAAGEA-ALTDGTEALLTGCSSCTGSLHSYCC

41

48.8%

NZ_CP029194.1and 1 other:

NZ_CP059991.1 Lanthipeptides: H4W23_RS35675_lanthipeptide

Lanthipeptides: DEJ46_RS04155_lanthipeptide

2

DNPAGSLYTEGLAKTMNAMTNPEVAIGTNCSSCTASRPGFCC

43

DNPAG LY G A A+T+ A+ T CSSCT S +CC

1

DNPAGPLYVGGAAGEA-ALTDATEALLTGCSSCTGSWHSYCC

41

48.8%

NZ_CP069396.1:

Lanthipeptides: JRI60_RS03735_lanthipeptide

3

NPAGSLYTEGLAKTMNAMTNPEVAIGTNCSSCTASRPGFCC

43

NPAG LY G A T NA+T+ A+ T CSSC+ S +CC

2

NPAGPLYVGG-AATENALTDASDALVTRCSSCSGSAGSYCC

41

48.8%

NZ_JH941044.1:

Lanthipeptides: Y19_RS0126875_lanthipeptide

2

DNPAGSLYTEGLAKTMNAMTNPEVAIGTNCSSCTASRPGFCC

43

DNPAG LY G A A+T+ A+ T CSSCT S +CC

1

DNPAGPLYVGGAAGEA-ALTDATEALFTGCSSCTGSWHSYCC

41

47.2%

NZ_CP093340.1:

Lanthipeptides: MNO14_RS04685_lanthipeptide

1

YDNPAGSLYTEGLAKTMNAMTNPEVAIGTNCSSCTASRPGFCC

43

Y+NPAG+LY EG+A T AMT+ + T CSSCTAS P CC

11

YENPAGALYVEGIAATEAAMTDKSFLLLTQCSSCTASIPAHCC

53

46.5%

NZ_CP034669.1:

Lanthipeptides: EJ065_RS19470_lanthipeptide

3

NPAGSLYTEGLAKTMNAMTNPEVAIGTNCSSCTASRPGFCC

43

NPAG ++ GL +T A+T + T CSSC+AS GFCC

2

NPAGPVFVGGL-RTEQALTESNLVENTGCSSCSASTTGFCC

41

44.2%

NZ_CP012109.1:

Lanthipeptides: A176_RS31295_lanthipeptide

3

NPAGSLYTEGLAKTMNAMTNPEVAIGTNCSSCTASRPGFCC

43

NPAG LY G A T A+T+ + I T CSSC+AS GFCC

13

NPAGPLYVGGDA-TEAALTDESLMIFTGCSSCSASGTGFCC

52

44.2%

NZ_CP071090.1:

Lanthipeptides: JY651_RS36970_lanthipeptide

3

NPAGSLYTEGLAKTMNAMTNPEVAIGTNCSSCTASRPGFCC

43

NPAG LY G A T A+T+ +GT CS CTASRP CC

13

NPAGPLYVGGTA-TEAALTDAAPMMGTGCSICTASRPVVCC

52

MIBiG 4.0 matches for KR767_RS10085

11.6%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

26

AIGTNCSSCTASR

38

A+G N CT ++

11

ALGNNGGWCTLTK

23

allorf_2267459_2267614

Leader:

MHDETREGG

Core:

SCPSFVLLGRGCDQSRFVDAALQGRYRVPHKHLSFSRSKGHL

Core with dehydrations:

DhaCysPDhaFVLLGRGCysDQDhaRFVDAALQGRYRVPHKHLDhaFDhaRDhaKGHL

antiSMASH-DB 4.0 matches for allorf_2267459_2267614

100.0%

NZ_CP077072.1:

Lanthipeptides: allorf_2267459_2267614_lanthipeptide

1

SCPSFVLLGRGCDQSRFVDAALQGRYRVPHKHLSFSRSKGHL

42

SCPSFVLLGRGCDQSRFVDAALQGRYRVPHKHLSFSRSKGHL

1

SCPSFVLLGRGCDQSRFVDAALQGRYRVPHKHLSFSRSKGHL

42

allorf_2268058_2268276

Leader:

MAHGTSCADMFKLIIFHELMAMLWA

Core:

ACMTMIVVLIYPGYGAIWKVFLFWGALAQVLVALRVAMDRRKRRANH

Core with dehydrations:

ACysMDhbMIVVLIYPGYGAIWKVFLFWGALAQVLVALRVAMDRRKRRANH

antiSMASH-DB 4.0 matches for allorf_2268058_2268276

100.0%

NZ_CP077072.1:

Lanthipeptides: allorf_2268058_2268276_lanthipeptide

1

ACMTMIVVLIYPGYGAIWKVFLFWGALAQVLVALRVAMDRRKRRANH

47

ACMTMIVVLIYPGYGAIWKVFLFWGALAQVLVALRVAMDRRKRRANH

1

ACMTMIVVLIYPGYGAIWKVFLFWGALAQVLVALRVAMDRRKRRANH

47

allorf_2268112_2268327

Leader:

MHASLAHLHAG

Core:

DKCNHFSVIRPSLPSIHGHPKRHQHLGQRAPEKKHLPDGPVTRVDEYDNHRHACSPEHGH

Core with dehydrations:

DKCysNHFDhaVIRPDhaLPDhaIHGHPKRHQHLGQRAPEKKHLPDGPVDhbRVDEYDNHRHACysDhaPEHGH

antiSMASH-DB 4.0 matches for allorf_2268112_2268327

100.0%

NZ_CP077072.1:

Lanthipeptides: allorf_2268112_2268327_lanthipeptide

1

DKCNHFSVIRPSLPSIHGHPKRHQHLGQRAPEKKHLPDGPVTRVDEYDNHRHACSPEHGH

60

DKCNHFSVIRPSLPSIHGHPKRHQHLGQRAPEKKHLPDGPVTRVDEYDNHRHACSPEHGH

1

DKCNHFSVIRPSLPSIHGHPKRHQHLGQRAPEKKHLPDGPVTRVDEYDNHRHACSPEHGH

60

10.0%

NZ_CP099547.1:

Lanthipeptides: allorf_0569907_0570044_lanthipeptide

7

SVIRPSLPSIHGHP

20

S++RP+L ++ G P

10

SLVRPALGALGGSP

23

allorf_2268889_2269032

Leader:

MPFSAMRRGTHAAS

Core:

HRMRRRSLVRLACHRIHQDGPVHLPRGSEISGN

Core with dehydrations:

HRMRRRDhaLVRLACysHRIHQDGPVHLPRGDhaEIDhaGN

antiSMASH-DB 4.0 matches for allorf_2268889_2269032

100.0%

NZ_CP077072.1:

Lanthipeptides: allorf_2268889_2269032_lanthipeptide

1

HRMRRRSLVRLACHRIHQDGPVHLPRGSEISGN

33

HRMRRRSLVRLACHRIHQDGPVHLPRGSEISGN

1

HRMRRRSLVRLACHRIHQDGPVHLPRGSEISGN

33

24.2%

NZ_CP116936.1:

Lanthipeptides: allorf_2855879_2856049_lanthipeptide

11

LACHRIHQDGPVHLPRGSE

29

+AC R H P H R +E

6

VACSRSHPQPPPHHQRSAE

24

18.2%

NZ_FNPT01000004.1:

Lanthipeptides: allorf_361247_361429_lanthipeptide

13

CHRIHQDGPVHLPRG

27

C I Q GP PRG

30

CDEIEQSGPAAQPRG

44

with 4 more sequence matches

18.2%

NZ_LT575476.1and 1 other:

NZ_LT575476.1 Lanthipeptides: allorf_0444250_0444393_lanthipeptide

Lanthipeptides: allorf_0444250_0444393_lanthipeptide

4

RRRSLVRLACHRIHQ

18

RRR L L C ++

1

RRRELFSLKCKEFYE

15

16.7%

NZ_CP064030.1:

Lanthipeptides: allorf_1950344_1950583_lanthipeptide

7

SLVRLACHRIHQDGPVHLPRG

27

S R C+R G VH G

15

SATRTQCYRYRNAGKVHGKTG

35

15.2%

NZ_KZ454939.1:

Lanthipeptides: allorf_0215974_0216129_lanthipeptide

16

IHQDGPVH

23

++QD PVH

2

VNQDSPVH

9

10.7%

NZ_KB900614.1:

Lanthipeptides: allorf_2973181_2973414_lanthipeptide

4

RRRSLVRLACHRIHQ

18

RR + C R+HQ

15

RRAGWITEGCQRVHQ

29

allorf_2272776_2272946

Leader:

MCRSDMSAKCLLANRKILLEDVAGL

Core:

VRLLQVRALRATGCRVEPVARKARSYMASVT

Core with dehydrations:

VRLLQVRALRADhbGCysRVEPVARKARDhaYMADhaVDhb

antiSMASH-DB 4.0 matches for allorf_2272776_2272946

100.0%

NZ_CP077072.1:

Lanthipeptides: allorf_2272776_2272946_lanthipeptide

1

VRLLQVRALRATGCRVEPVARKARSYMASVT

31

VRLLQVRALRATGCRVEPVARKARSYMASVT

1

VRLLQVRALRATGCRVEPVARKARSYMASVT

31

19.4%

NZ_CP069338.1:

Lanthipeptides: allorf_01719481_01719645_lanthipeptide

5

QVRALRATGCR

15

+ RAL TGC+

2

KWRALHPTGCQ

12

allorf_2273844_2273954

Leader:

MPPSEHIAIPFS

Core:

LPISRENTRCPPISTRLDDCCECS

Core with dehydrations:

LPIDhaRENDhbRCysPPIDhaDhbRLDDCysCysECysDha

antiSMASH-DB 4.0 matches for allorf_2273844_2273954

100.0%

NZ_CP077072.1:

Lanthipeptides: allorf_2273844_2273954_lanthipeptide

1

LPISRENTRCPPISTRLDDCCECS

24

LPISRENTRCPPISTRLDDCCECS

1

LPISRENTRCPPISTRLDDCCECS

24

29.2%

NZ_QKUF01000002.1:

Lanthipeptides: EI42_RS32305_lanthipeptide

14

STRLDDCCECS

24

ST +DD C CS

2

STGIDDSCSCS

12

25.0%

NZ_CP090100.1and 3 others:

NZ_SIJR01000001.1 Lanthipeptides: allorf_2033312_2033491_lanthipeptideNZ_SIKP01000006.1 Lanthipeptides: allorf_320758_320937_lanthipeptideNZ_SIMU01000019.1 Lanthipeptides: allorf_19855_20034_lanthipeptide

Lanthipeptides: allorf_349430_349609_lanthipeptide

9

RCPPISTRL

17

R PPIS RL

11

RTPPISRRL

19

with 2 more sequence matches

25.0%

NZ_LT607733.1:

Lanthipeptides: GA0070610_RS30575_lanthipeptide

11

PPISTRLDDCCEC

23

PPI + CC C

2

PPIDGHTEKCCHC

14

21.6%

NZ_CP069396.1and 1 other:

NZ_CP069396.1 Lanthipeptides: allorf_03493802_03493966_lanthipeptide

Lanthipeptides: allorf_03493802_03493966_lanthipeptide

2

PISRENTRCPPISTRLDDCC

21

P+S C P S+R D C

5

PLSASAPVCGPSSSRFDSPC

24

MIBiG 4.0 matches for allorf_2273844_2273954

16.7%

BGC0001155.5 (AGY49587.1):

Thiopeptide: GE2270

20

CCECS

24

CC CS

9

CCSCS

13

allorf_2280552_2280674

Leader:

MGLRPEREGRASQRA

Core:

LLRRRHRTILKSPGQRHGRTCRIYM

Core with dehydrations:

LLRRRHRDhbILKDhaPGQRHGRDhbCysRIYM

antiSMASH-DB 4.0 matches for allorf_2280552_2280674

100.0%

NZ_CP077072.1:

Lanthipeptides: allorf_2280552_2280674_lanthipeptide

1

LLRRRHRTILKSPGQRHGRTCRIYM

25

LLRRRHRTILKSPGQRHGRTCRIYM

1

LLRRRHRTILKSPGQRHGRTCRIYM

25

36.0%

NZ_CAOJCM010000001.1:

Lanthipeptides: allorf_0381374_0381505_lanthipeptide

9

ILKSPGQRHGRTCRI

23

ILK+ G RH +CRI

1

ILKAKGNRH--SCRI

13

24.0%

NZ_CP101417.1:

Lanthipeptides: allorf_0369305_0369400_lanthipeptide

13

PGQRHGRTCRI

23

P HGRTC +

4

PPSLHGRTCGV

14

with 2 more sequence matches

17.1%

NZ_LUCO01000016.1:

Lanthipeptides: BMBG_RS27150_lanthipeptide

4

RRHRTILKSPGQRHGRTCRI

23

+ L G +GRTC +

6

SKQAANLTGLGNNYGRTCTL

25

13.7%

NC_019779.1:

Lanthipeptides: allorf_0212589_0212804_lanthipeptide

7

RTILKSPGQRHGRTCRI

23

R ++K P RHG R+

29

RCLVKHPDIRHGSAFRV

45

allorf_2285440_2285562

Leader:

MPLVIQDDISAG

Core:

HCDKTPGYMIDPHRSASFSMRHRLQSPI

Core with dehydrations:

HCysDKDhbPGYMIDPHRDhaADhaFDhaMRHRLQDhaPI

antiSMASH-DB 4.0 matches for allorf_2285440_2285562

100.0%

NZ_CP077072.1:

Lanthipeptides: allorf_2285440_2285562_lanthipeptide

1

HCDKTPGYMIDPHRSASFSMRHRLQSPI

28

HCDKTPGYMIDPHRSASFSMRHRLQSPI

1

HCDKTPGYMIDPHRSASFSMRHRLQSPI

28

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.03 out of 29.72

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.99 out of 20.47

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.06 out of 28.19

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

Additional weak hits (8):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.87 out of 29.38

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.91 out of 27.78

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.16 out of 21.55

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.99 out of 27.55

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.26 out of 20.01

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.26 out of 18.57

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.23 out of 20.01

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

KR767_RS10085 - Class II

Cleavage pHMM score: -4.00

RODEO score: 0

Monoisotopic mass: 4282.9 Da

Molecular weight: 4285.8 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4303.8 Da N = 1; 4321.8 Da N = 2; 4339.8 Da N = 3; 4357.9 Da N = 4; 4375.9 Da N = 5

allorf_2267459_2267614 - Class II

Cleavage pHMM score: -4.40

RODEO score: 0

Monoisotopic mass: 4603.4 Da

Molecular weight: 4606.2 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4624.3 Da N = 1; 4642.3 Da N = 2; 4660.3 Da N = 3; 4678.3 Da N = 4

allorf_2268058_2268276 - Class II

Cleavage pHMM score: -1.30

RODEO score: 0

Monoisotopic mass: 5385.0 Da

Molecular weight: 5388.5 Da

Number of bridges: 1

allorf_2268112_2268327 - Class II

Cleavage pHMM score: -4.70

RODEO score: 0

Monoisotopic mass: 6800.4 Da

Molecular weight: 6804.5 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 6822.5 Da N = 1; 6840.5 Da N = 2; 6858.5 Da N = 3

allorf_2268889_2269032 - Class II

Cleavage pHMM score: -6.70

RODEO score: 0

Monoisotopic mass: 3786.0 Da

Molecular weight: 3788.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3806.3 Da N = 1; 3824.4 Da N = 2

allorf_2272776_2272946 - Class II

Cleavage pHMM score: -6.10

RODEO score: 0

Monoisotopic mass: 3384.9 Da

Molecular weight: 3387.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3405.0 Da N = 1; 3423.1 Da N = 2; 3441.1 Da N = 3

allorf_2273844_2273954 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 2617.2 Da

Molecular weight: 2619.0 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 2637.0 Da N = 1

allorf_2280552_2280674 - Class II

Cleavage pHMM score: -6.70

RODEO score: 0

Monoisotopic mass: 3049.7 Da

Molecular weight: 3051.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3069.7 Da N = 1; 3087.7 Da N = 2

allorf_2285440_2285562 - Class II

Cleavage pHMM score: -2.70

RODEO score: 0

Monoisotopic mass: 3176.6 Da

Molecular weight: 3178.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3196.6 Da N = 1; 3214.6 Da N = 2; 3232.7 Da N = 3; 3250.7 Da N = 4

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
NtrC	Nitrogen regulatory protein C
VqsM	Regulator of quorum-sensing signalling systems
ZuR variant 1	Zinc-responsive repressor

NZ_CP077072.1 - Region 8 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 2,536,572 - 2,559,448 nt. (total: 22,877 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase reductase

KR767_RS11190: alkyl hydroperoxide reductase/ Thiol specific

smcogs: SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

KR767_RS11225: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Hydrolases: hydrolase

KR767_RS11240: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Lyases: cyclase

KR767_RS11210: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002703.2	0.48	ribosomal	archalan α	Halorussus salinus
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000584.5	0.47	ribosomal	colicin V	Escherichia coli
BGC0000504.5	0.46	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0002704.2	0.46	ribosomal	archalan β	Halorussus salinus
BGC0001579.4	0.46	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000500.5	0.46	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001387.5	0.45	other (other)	nucleocidin	Streptomyces calvus
BGC0000503.5	0.45	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0002346.3	0.43	ribosomal	kyamicin	Saccharopolyspora sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002703.2	0.48	ribosomal	archalan α	Halorussus salinus
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000584.5	0.47	ribosomal	colicin V	Escherichia coli
BGC0000504.5	0.46	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0002704.2	0.46	ribosomal	archalan β	Halorussus salinus
BGC0001579.4	0.46	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000500.5	0.46	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001387.5	0.45	other (other)	nucleocidin	Streptomyces calvus
BGC0000503.5	0.45	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0002346.3	0.43	ribosomal	kyamicin	Saccharopolyspora sp.

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for KR767_RS11210

allorf_2541699_2541854

Leader:

MRQKGGVRVRCYRSHPGRRGGRFTGRAQGA

Core:

LLHKPPCRSAPRARPIRSGGL

Core with dehydrations:

LLHKPPCysRDhaAPRARPIRDhaGGL

antiSMASH-DB 4.0 matches for allorf_2541699_2541854

100.0%

NZ_CP077072.1:

Lanthipeptides: allorf_2541699_2541854_lanthipeptide

1

LLHKPPCRSAPRARPIRSGGL

21

LLHKPPCRSAPRARPIRSGGL

1

LLHKPPCRSAPRARPIRSGGL

21

38.5%

NZ_CP077072.1:

Lanthipeptides: allorf_4767256_4767366_lanthipeptide

6

PCRSAPRARPI

16

PCRSAPRARP+

12

PCRSAPRARPV

22

24.1%

NZ_JAGIYX010000033.1:

Lanthipeptides: allorf_81159_81302_lanthipeptide

8

RSAPRARPIRSGG

20

R+ RAR +R+GG

6

RTGRRARCLRAGG

18

allorf_2549811_2549951

Leader:

MPTGITAPRRDVSRRSHLHENGKRSMSSAGG

Core:

CNTPYAPPRHAEPHD

Core with dehydrations:

CysNDhbPYAPPRHAEPHD

antiSMASH-DB 4.0 matches for allorf_2549811_2549951

100.0%

NZ_CP077072.1:

Lanthipeptides: allorf_2549811_2549951_lanthipeptide

1

CNTPYAPPRHAEPHD

15

CNTPYAPPRHAEPHD

1

CNTPYAPPRHAEPHD

15

43.8%

NC_009621.1and 6 others:

NC_017327.1 Lanthipeptides: allorf_0124171_0124311_lanthipeptideNZ_CP021217.1 Lanthipeptides: allorf_1159796_1159936_lanthipeptideNZ_CP088111.1 Lanthipeptides: allorf_0786224_0786295_lanthipeptideNZ_NBUK01000063.1 Lanthipeptides: allorf_7325_7396_lanthipeptideNZ_VISX01000063.1 Lanthipeptides: allorf_1360_1431_lanthipeptideNZ_VITA01000039.1 Lanthipeptides: allorf_07280_07351_lanthipeptide

Lanthipeptides: allorf_1019980_1020051_lanthipeptide

6

APPRHAEPHD

15

AP R AEP D

3

APARSAEPAD

12

26.9%

NZ_CP079114.1and 2 others:

NZ_CP079114.1 Lanthipeptides: allorf_2712645_2712809_lanthipeptideNZ_CP079114.1 Lanthipeptides: allorf_2712645_2712809_lanthipeptide

Lanthipeptides: allorf_2712645_2712809_lanthipeptide

2

NTPYAPPRHAEP

13

NT APPR P

3

NTGAAPPRFVRP

14

with 1 more sequence matches

25.9%

NZ_CP076103.1:

Lanthipeptides: allorf_4159822_4159995_lanthipeptide

6

APPRHAEP

13

APPRHA P

8

APPRHANP

15

allorf_2555924_2556031

Leader:

MPRIRQLRLIAG

Core:

TRLTQDKNRCAAPYAYKRDVRRF

Core with dehydrations:

DhbRLDhbQDKNRCysAAPYAYKRDVRRF

antiSMASH-DB 4.0 matches for allorf_2555924_2556031

100.0%

NZ_CP077072.1:

Lanthipeptides: allorf_2555924_2556031_lanthipeptide

1

TRLTQDKNRCAAPYAYKRDVRRF

23

TRLTQDKNRCAAPYAYKRDVRRF

1

TRLTQDKNRCAAPYAYKRDVRRF

23

20.8%

NZ_LT630004.1:

Lanthipeptides: allorf_2780737_2780889_lanthipeptide

4

TQDKNRCAAPY

14

+ D+N C AP+

11

SSDRNLCDAPW

21

allorf_2556044_2556175

Leader:

MTSLSACRQRRCVGG

Core:

VPCSWSRAGEGSRRHIRVRRTQAVGCTG

Core with dehydrations:

VPCysDhaWDhaRAGEGDhaRRHIRVRRDhbQAVGCysDhbG

antiSMASH-DB 4.0 matches for allorf_2556044_2556175

100.0%

NZ_CP077072.1:

Lanthipeptides: allorf_2556044_2556175_lanthipeptide

1

VPCSWSRAGEGSRRHIRVRRTQAVGCTG

28

VPCSWSRAGEGSRRHIRVRRTQAVGCTG

1

VPCSWSRAGEGSRRHIRVRRTQAVGCTG

28

25.0%

NZ_JAJNOJ010000002.1:

Lanthipeptides: allorf_7584253_7584438_lanthipeptide

1

VPCSWSRAGE

10

VPC RAGE

10

VPCRPPRAGE

19

18.6%

NZ_CP067396.1and 1 other:

NZ_CP110813.1 Lanthipeptides: allorf_0964079_0964300_lanthipeptide

Lanthipeptides: allorf_0994793_0995014_lanthipeptide

11

GSRRHIRVRRTQAVGC

26

G+RR R R+ A GC

3

GNRRSDRKRKVGAAGC

18

with 4 more sequence matches

17.5%

NZ_CP010407.1and 2 others:

NZ_CP010407.1 Lanthipeptides: allorf_8470670_8470873_lanthipeptideNZ_CP010407.1 Lanthipeptides: allorf_8470670_8470873_lanthipeptide

Lanthipeptides: allorf_8470670_8470873_lanthipeptide

1

VPCSWSRAGEGS

12

VPC+ R G GS

9

VPCTPDRHGPGS

20

17.5%

NZ_CP038504.1:

Lanthipeptides: allorf_0573691_0573876_lanthipeptide

3

CSWSRAGEGSRRHIRVRRTQAV

24

C W R +R ++ V R+Q +

14

CIWPRLLICTRANLPVLRSQTM

35

16.7%

NZ_CABWKH010000001.1and 1 other:

NZ_CP010411.1 Lanthipeptides: allorf_1259634_1259786_lanthipeptide

Lanthipeptides: allorf_022146_022298_lanthipeptide

2

PCSWSRAG

9

PC W RAG

3

PCRWHRAG

10

16.7%

NZ_CP097263.1:

Lanthipeptides: M3Q35_RS17960_lanthipeptide

4

SWSRAGEGSRRHIRVRRTQAVGC

26

SW+R GE + ++ A+GC

13

SWTRRGEAALNNV-----LAIGC

30

allorf_2556081_2556245

Leader:

MAGFRAHGVALA

Core:

KGAEGTYVSGERKLSVVPGRAGGRCVLRGNACVESPCNRACA

Core with dehydrations:

KGAEGDhbYVDhaGERKLDhaVVPGRAGGRCysVLRGNACysVEDhaPCysNRACysA

antiSMASH-DB 4.0 matches for allorf_2556081_2556245

100.0%

NZ_CP077072.1:

Lanthipeptides: allorf_2556081_2556245_lanthipeptide

1

KGAEGTYVSGERKLSVVPGRAGGRCVLRGNACVESPCNRACA

42

KGAEGTYVSGERKLSVVPGRAGGRCVLRGNACVESPCNRACA

1

KGAEGTYVSGERKLSVVPGRAGGRCVLRGNACVESPCNRACA

42

23.8%

NZ_CP016767.1and 3 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide

Lanthipeptides: BCV50_RS13415_lanthipeptide

14

LSVVPGRAGGRCVLRGNACVESPCNRAC

41

LSV+ G + N C + C RAC

5

LSVITGY------ISSNTCPTTACTRAC

26

21.4%

NZ_CP120210.1:

Lanthipeptides: allorf_4400817_4401044_lanthipeptide

12

RKLSVVPGRAGGRCVLRGNACVES

35

R +V P GR +LR + V S

3

RHRAVAPPSDAGRVLLRSDVVVSS

26

with 9 more sequence matches

19.0%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

8

VSGERKLSVVPGRAGGRCVL

27

+ LS V G GG C L

2

TTNTFSLSDVLGNTGGWCTL

21

16.7%

NZ_BLIS01000009.1and 5 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

27

LRGNACVESPCNRAC

41

+ N C S C RAC

25

VSANTCPTSACTRAC

39

16.7%

NZ_CABWKH010000001.1:

Lanthipeptides: allorf_004703_004852_lanthipeptide

8

VSGERKLSVVPGRAG

22

V G+R+ +V GRA

24

VFGDRRYFLVLGRAA

38

16.7%

NZ_CP051884.1and 3 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide

Lanthipeptides: HGK68_RS15130_lanthipeptide

27

LRGNACVESPCNRAC

41

+ N C S C RAC

14

ISNNTCPSSACTRAC

28

14.3%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide

Lanthipeptides: IE339_RS06335_lanthipeptide

27

LRGNACVESPCNRAC

41

+ N C + C RAC

14

ISTNTCPTTSCTRAC

28

14.3%

NZ_JALAPU010000003.1and 9 others:

NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptideNZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptideNZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide

Lanthipeptides: MOD17_RS07925_lanthipeptide

27

LRGNACVESPCNRAC

41

+ N C + C RAC

12

ISSNTCPTTACTRAC

26

14.3%

NZ_LR134317.1and 1 other:

NZ_LR134317.1 Lanthipeptides: EL136_RS01690_lanthipeptide

Lanthipeptides: EL136_RS01690_lanthipeptide

27

LRGNACVESPCNRAC

41

+ N C + C RAC

19

ISANTCPTTSCTRAC

33

14.3%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15355_lanthipeptide

Lanthipeptides: BHL26_RS15355_lanthipeptide

27

LRGNACVESPCNRAC

41

+ N C + C RAC

19

ISSNTCPSTACTRAC

33

14.3%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide

Lanthipeptides: CQS04_RS09625_lanthipeptide

27

LRGNACVESPCNRAC

41

+ N+C + C RAC

14

ISANSCPTTACTRAC

28

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.92 out of 29.65

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.01 out of 26.85

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.80 out of 20.47

Confidence: medium

Additional weak hits (8):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.92 out of 26.33

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.61 out of 29.38

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.70 out of 39.62

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.03 out of 26.12

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.50 out of 20.01

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.94 out of 27.55

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.16 out of 30.22

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.17 out of 28.19

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

allorf_2541699_2541854 - Class II

Cleavage pHMM score: -7.00

RODEO score: 0

Monoisotopic mass: 2245.3 Da

Molecular weight: 2246.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2264.7 Da N = 1

allorf_2549811_2549951 - Class II

Cleavage pHMM score: -2.20

RODEO score: 0

Monoisotopic mass: 1685.7 Da

Molecular weight: 1686.8 Da

Number of bridges: 1

allorf_2555924_2556031 - Class II

Cleavage pHMM score: -6.30

RODEO score: 0

Monoisotopic mass: 2791.5 Da

Molecular weight: 2793.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2811.2 Da N = 1

allorf_2556044_2556175 - Class II

Cleavage pHMM score: -5.20

RODEO score: 0

Monoisotopic mass: 2991.6 Da

Molecular weight: 2993.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3011.4 Da N = 1; 3029.4 Da N = 2; 3047.4 Da N = 3

allorf_2556081_2556245 - Class II

Cleavage pHMM score: -5.50

RODEO score: 0

Monoisotopic mass: 4205.1 Da

Molecular weight: 4207.8 Da

Number of bridges: 4

TFBS definitions

Regulator	Description
LexA variant 1	Repressor of DNA damage response
RutR	Regulator of the pyrimidine and purine metabolism
VqsM	Regulator of quorum-sensing signalling systems

NZ_CP077072.1 - Region 9 - NRPS

Download region GenBank file

Download region SVG

Location: 2,825,728 - 2,897,422 nt. (total: 71,695 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acyltransferase

KR767_RS12475: polyketide synthase associated protein papA3

smcogs: SMCOG1209: polyketide synthase associated protein papA3

Hydrolases: peptidase

KR767_RS12555: gamma-glutamyltranspeptidase

smcogs: SMCOG1274: gamma-glutamyltranspeptidase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001758.4	0.77	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833.4	0.77	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.76	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001132.4	0.75	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.75	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.75	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.75	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001641.4	0.73	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001261.3	0.69	NRPS	AM-toxin	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001758.4	0.77	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833.4	0.77	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.76	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001132.4	0.75	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.75	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.75	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.75	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001641.4	0.73	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001261.3	0.69	NRPS	AM-toxin	Alternaria alternata

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46

Confidence: strong

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.60 out of 29.72

Confidence: medium

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.28 out of 20.01

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.60 out of 19.26

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.19 out of 23.79

Confidence: medium

Additional weak hits (5):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 19.13 out of 30.97

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.21 out of 20.01

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.22 out of 20.97

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.59 out of 18.57

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.02 out of 32.74

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 9, location 2825727 - 2897422:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Leu - Ser - X - Ile - Leu - X - Leu - Gln - Ile)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

KR767_RS12475: Leu - Ser - X - Ile - Leu - X - Leu - Gln - Ile

Search NORINE for peptide: strict or relaxed

AMP-binding (703..1095): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHAFDASAWEPFLLVGGDTNNYGPTETTVVATS
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1757..2160): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFMCSGEHNLYGPTEAAVDVTA
Nearest Stachelhaus code(s):: Ser DVWHMSLVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2842..3239): X

nrpys: Gln, Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWSSFDATITSTKIVIGGEINEYGPTETVVGCAI
Nearest Stachelhaus code(s):: Gln or Asn DATKVGEVGK (91% 8Å match); Asn DATKVGEVGK (88% 8Å match); OH-Asn or Asn DATKVGEVGK (79% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3922..4318): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: LNNAFDASTMEGFAMSGGELNCYGPTETTTYATT
Nearest Stachelhaus code(s):: Ile DAMFMGCTFK (88% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (5422..5811): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHAFDASAWEPFLLVGGDTNNYGPTETTVVATS
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (6494..6891): X

nrpys: Asn, OH-Asn, Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDATVTSVKIVIGGEVNEYGPTETVVGCAI
Nearest Stachelhaus code(s):: Asn DATKVGEVGK (88% 8Å match); OH-Asn or Asn DATKVGEVGK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (7575..7964): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHAFDASAWEPFLLVGGDTNNYGPTETTVVATS
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (8626..9027): Gln

nrpys: Gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: HWQTFDASVWETQLFCGGEVNLYGPTETTIDATS
Nearest Stachelhaus code(s):: Gln DAWQFGLIDK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (9709..10106): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: LNNAFDASTVEGFVMCGGEVHCYGPTEATTYATT
Nearest Stachelhaus code(s):: Ile DALFMGCTYK (88% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ArgR	Regulator of arginine biosynthesis genes
CRP	Cyclic AMP receptor protein
IolR	Regulator of the inositol catabolism
NtrC	Nitrogen regulatory protein C
RpoN	Regulator of nitrogen assimilation and virulence

NZ_CP077072.1 - Region 10 - NRPS,T1PKS

Download region GenBank file

Download region SVG

Location: 3,682,473 - 3,735,023 nt. (total: 52,551 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

KR767_RS15990: nucleotide sugar dehydrogenase

smcogs: SMCOG1152: nucleotide sugar dehydrogenase

Transferases: glycosyltransferase

KR767_RS15895: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

KR767_RS15905: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

KR767_RS15910: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

KR767_RS15975: sugar transferase

smcogs: SMCOG1146: sugar transferase

Hydrolases: deacetylase

KR767_RS15900: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Lyases: dehydratase

KR767_RS15985: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase

KR767_RS15935: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

KR767_RS15940: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.77	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.75	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.74	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000342.4	0.72	NRPS	enniatin	Fusarium equiseti
BGC0001128.4	0.71	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000307.4	0.67	NRPS	AbT1	Aureobasidium pullulans
BGC0002164.2	0.66	NRPS	peramine	Epichloe festucae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.70	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.70	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.68	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.67	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000307.4	0.67	NRPS	AbT1	Aureobasidium pullulans
BGC0002164.2	0.66	NRPS	peramine	Epichloe festucae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.77 out of 29.51

Confidence: medium

Additional weak hits (11):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.52 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.05 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.76 out of 29.38

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.25 out of 20.97

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.17 out of 18.57

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.22 out of 21.55

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.55 out of 28.19

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 35.63

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.43 out of 35.63

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.44 out of 28.19

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.45 out of 35.63

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 10, location 3682472 - 3735023:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Val - mal) + (X - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

KR767_RS15935: X - X

AMP-binding (486..882): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FAMTFDIAFMELQAISGGEWNGYGPTETTVYSTY
Nearest Stachelhaus code(s):: Gly DILQIGMVWK (82% 8Å match); Ala DILQITLVYK (71% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1544..1828): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: RTTL--------HTVWLDE--------ATPAIAF
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

KR767_RS15940: Val - mal

Search NORINE for peptide: strict or relaxed

AMP-binding (18..397): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LHSAFDASTLEAWLLTGGEVNGYGPTECTTFATT
Nearest Stachelhaus code(s):: Val DALWLGGTFK (82% 8Å match); bOH-Val DALWLGGTFK (76% 8Å match)
Stachelhaus code match:: 100% (strong)

PKS_AT (1113..1401): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 83.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 158.1
Methylmalonyl-CoA: 77.5
inactive: 73.6
Methoxymalonyl-CoA: 71.2
Propionyl-CoA: 54.1
Isobutyryl-CoA: 35.4
Ethylmalonyl-CoA: 31.9
Benzoyl-CoA: 30.0
Acetyl-CoA: 29.8
fatty_acid: 21.9
CHC-CoA: 21.9
trans-1,2-CPDA: 18.9
3-Methylbutyryl-CoA: 6.8
2-Methylbutyryl-CoA: -2.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
DosR	Hypoxia stress response regulator

NZ_CP077072.1 - Region 11 - NI-siderophore

Download region GenBank file

Download region SVG

Location: 3,880,425 - 3,913,098 nt. (total: 32,674 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: sulfotransferase

KR767_RS16595: glutathione S-transferase

smcogs: SMCOG1193: glutathione S-transferase

Lyases: decarboxylase

KR767_RS16565: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000946.5	0.79	other (other)	vibrioferrin	Vibrio parahaemolyticus
BGC0001408.5	0.73	other (other)	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331
BGC0002527.2	0.73	other (other)	vibrioferrin	Azotobacter vinelandii CA
BGC0000947.5	0.63	other (other)	vibrioferrin	Vibrio alginolyticus
BGC0000943.5	0.49	other (other)	staphyloferrin B	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002692.2	0.48	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0002683.2	0.45	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0002694.2	0.41	other (other)	roseobactin	Phaeobacter inhibens 2.10
BGC0002466.3	0.40	NRPS	peucechelin	Streptomyces peucetius subsp. caesius ATCC 27952
BGC0002755.2	0.34	NRPS	clovibactin	Eleftheria terrae P9846

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000946.5	0.79	other (other)	vibrioferrin	Vibrio parahaemolyticus
BGC0001408.5	0.73	other (other)	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331
BGC0002527.2	0.73	other (other)	vibrioferrin	Azotobacter vinelandii CA
BGC0000947.5	0.63	other (other)	vibrioferrin	Vibrio alginolyticus
BGC0000943.5	0.49	other (other)	staphyloferrin B	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002692.2	0.48	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0002683.2	0.45	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0002694.2	0.41	other (other)	roseobactin	Phaeobacter inhibens 2.10
BGC0002466.3	0.40	NRPS	peucechelin	Streptomyces peucetius subsp. caesius ATCC 27952
BGC0002755.2	0.34	NRPS	clovibactin	Eleftheria terrae P9846

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.28 out of 29.38

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.65 out of 28.19

Confidence: medium

Additional weak hits (12):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.47 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.53 out of 29.38

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 20.30 out of 31.73

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.63 out of 32.74

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.06 out of 26.06

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.09 out of 30.98

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.74 out of 28.14

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.41 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.65 out of 28.19

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.40 out of 32.93

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 24.70 out of 30.12

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 21.63 out of 35.63

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
FuR variant 1	Ferric Uptake Regulator
ZuR variant 1	Zinc-responsive repressor

NZ_CP077072.1 - Region 12 - NRP-metallophore,NRPS

Download region GenBank file

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Location: 4,117,764 - 4,182,637 nt. (total: 64,874 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase reductase

KR767_RS17575: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

KR767_RS17625: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Transferases: PPTase acyltransferase

KR767_RS17615: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

KR767_RS17620: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1060: 4'-phosphopantetheinyl transferase

Hydrolases: esterase hydrolase

KR767_RS17485: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

KR767_RS17595: thioesterase

smcogs: SMCOG1004: thioesterase

Isomerases: isomerase

KR767_RS17605: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase

KR767_RS17540: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

KR767_RS17590: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: permease

KR767_RS17490: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002286.3	0.61	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.61	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.60	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001758.4	0.60	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001825.4	0.60	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001641.4	0.60	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4	0.59	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.59	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000357.5	0.59	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002286.3	0.64	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.64	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.64	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001758.4	0.64	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001825.4	0.63	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001641.4	0.63	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4	0.63	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.63	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000357.5	0.63	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.16 out of 20.97

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.38 out of 19.26

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.54 out of 20.97

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.94 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.18 out of 29.38

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.14 out of 29.72

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.03 out of 29.72

Confidence: medium

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.56 out of 33.14

Confidence: medium

Additional weak hits (21):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.56 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.27 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.08 out of 29.25

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 19.33 out of 30.97

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.78 out of 29.38

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.91 out of 31.73

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.57 out of 26.85

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.20 out of 21.55

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.45 out of 30.25

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 24.26 out of 30.22

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.94 out of 29.65

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.17 out of 28.19

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.46 out of 32.93

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.52 out of 32.93

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.50 out of 35.63

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.73 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.35 out of 28.14

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.80 out of 29.25

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.45 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.85 out of 28.19

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.32 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 12, location 4117763 - 4182637:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser - Cys) + (Me-Cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

KR767_RS17540: Ser - Cys

Search NORINE for peptide: strict or relaxed

AMP-binding (563..940): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TDLSFDLSVYDANCLLGGDIALGGTTETAIHSTF
Nearest Stachelhaus code(s):: Ser DLYNLGLIHK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1597..1980): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TDVSFDLSVFDANSLISGDIALGGATEASVWSNY
Nearest Stachelhaus code(s):: Cys DLFNLSLVWK (79% 8Å match)
Stachelhaus code match:: 100% (strong)

KR767_RS17545: Cys

Search NORINE for peptide: strict or relaxed

AMP-binding (529..922): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TDIAFDLSVYDGNSLLSGDIGLGGATEASIWSNY
Nearest Stachelhaus code(s):: Cys DLYNLSLIWK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

KR767_RS17590: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (36..435): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: NESLFPLACPGGALQAGGAQQVYGMAEGLLCYTR
Nearest Stachelhaus code(s):: diOH-Bz PLPAQGVLCK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CcpA	Catabolite control protein A
FuR variant 1	Ferric Uptake Regulator
NtrC	Nitrogen regulatory protein C
RpoN	Regulator of nitrogen assimilation and virulence
ZuR variant 2	Zinc-responsive repressor

NZ_CP077072.1 - Region 13 - T1PKS

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Location: 4,502,945 - 4,548,698 nt. (total: 45,754 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthase

KR767_RS19085: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: transport

KR767_RS19035: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000056.3	0.70	PKS	esperamicin	Actinomadura verrucosospora
BGC0001164.3	0.57	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.57	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001284.4	0.57	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001276.3	0.56	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002191.2	0.56	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001273.3	0.56	PKS	asperlactone	Aspergillus ochraceus
BGC0002154.2	0.56	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.56	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001257.3	0.56	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000056.3	0.70	PKS	esperamicin	Actinomadura verrucosospora
BGC0001164.3	0.57	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.57	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001284.4	0.57	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001276.3	0.56	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002191.2	0.56	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001273.3	0.56	PKS	asperlactone	Aspergillus ochraceus
BGC0002154.2	0.56	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.56	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001257.3	0.56	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

Additional weak hits (8):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.51 out of 21.84

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.68 out of 28.14

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.91 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.96 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 20.87 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.95 out of 31.73

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 23.66 out of 30.22

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.79 out of 22.40

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

KR767_RS19085: mal

PKS_AT (610..837): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 77.8
Methoxymalonyl-CoA: 65.9
Methylmalonyl-CoA: 57.4
Ethylmalonyl-CoA: 31.9
Isobutyryl-CoA: 30.3
trans-1,2-CPDA: 24.2
inactive: 22.8
Benzoyl-CoA: 17.8
CHC-CoA: 17.6
Acetyl-CoA: 14.9
2-Methylbutyryl-CoA: 14.5
fatty_acid: 13.0
Propionyl-CoA: 12.7
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein

NZ_CP077072.1 - Region 14 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 4,753,378 - 4,776,317 nt. (total: 22,940 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: glycosyltransferase transferase

KR767_RS20360: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

KR767_RS20385: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Lyases: cyclase lyase

KR767_RS20370: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

KR767_RS20410: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000528.5	0.47	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001579.4	0.46	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000503.5	0.43	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0002698.2	0.43	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001210.5	0.43	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001364.3	0.42	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0002346.3	0.41	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000517.4	0.41	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001594.3	0.41	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0001229.4	0.41	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000528.5	0.47	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001579.4	0.46	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000503.5	0.43	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0002698.2	0.43	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001210.5	0.43	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001364.3	0.42	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0002346.3	0.41	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000517.4	0.41	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001594.3	0.41	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0001229.4	0.41	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for KR767_RS20370

KR767_RS20375

Leader:

MSNEMGFSSKSVSRAAEWRKQAGNGNPAGDLFANAFAEADIVGG

Core:

TEIAVTDCAMCTGSIKTTKITQCA

Core with dehydrations:

DhbEIAVDhbDCysAMCysDhbGDhaIKDhbDhbKIDhbQCysA

antiSMASH-DB 4.0 matches for KR767_RS20375

100.0%

NZ_CP077072.1:

Lanthipeptides: KR767_RS20375_lanthipeptide

1

TEIAVTDCAMCTGSIKTTKITQCA

24

TEIAVTDCAMCTGSIKTTKITQCA

1

TEIAVTDCAMCTGSIKTTKITQCA

24

66.7%

NZ_FNBR01000006.1and 1 other:

NZ_FUYT01000011.1 Lanthipeptides: B5X73_RS13320_lanthipeptide

Lanthipeptides: BLT40_RS18630_lanthipeptide

1

TEIAVTDCAMCTGSIKTTKITQCA

24

T++ VTDCAMCTGSIK T CA

1

TDMLVTDCAMCTGSIKNTIHIYCA

24

62.5%

NZ_CP095740.1:

Lanthipeptides: L2Y94_RS08185_lanthipeptide

1

TEIAVTDCAMCTGSIKTTKITQCA

24

TE+ VT CAMCTGSI+ T CA

1

TEMLVTGCAMCTGSIEHTIRIACA

24

with 14 more sequence matches

Only the first 10 are displayed here.

57.7%

NZ_CP077072.1:

Lanthipeptides: KR767_RS20380_lanthipeptide

1

TEIAVTDCAMCTGSIKT-TKITQCA

24

T+I VTDC MCTGSI T+ QC

1

TDIVVTDCVMCTGSIDARTRHIQCG

25

46.2%

NZ_CP095740.1:

Lanthipeptides: L2Y94_RS08180_lanthipeptide

1

TEIAVTDCAMCTGSIK-TTKITQCA

24

T+I VT+C +CTGS+ T+ QC

1

TDIIVTNCVLCTGSVDANTRHVQCG

25

22.6%

NZ_CP048887.1:

Lanthipeptides: BMG_RS29400_lanthipeptide

1

TEIAVTDCAMCTG

13

T +AVT A+C G

8

TPVAVTSSAVCIG

20

19.5%

NZ_CP010407.1and 4 others:

NZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptideNZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptideNZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptideNZ_JACHJY010000017.1 Lanthipeptides: GGE06_RS39715_lanthipeptide

Lanthipeptides: SVTN_RS37515_lanthipeptide

1

TEIAVTDCAMCTGSIKT

17

TE +T C+ CTGS+ +

22

TEALLTGCSSCTGSLHS

38

19.5%

NZ_CP029194.1and 1 other:

NZ_CP059991.1 Lanthipeptides: H4W23_RS35675_lanthipeptide

Lanthipeptides: DEJ46_RS04155_lanthipeptide

1

TEIAVTDCAMCTGSIKT

17

TE +T C+ CTGS +

22

TEALLTGCSSCTGSWHS

38

19.5%

NZ_JH941044.1:

Lanthipeptides: Y19_RS0126875_lanthipeptide

1

TEIAVTDCAMCTGSIKT

17

TE T C+ CTGS +

22

TEALFTGCSSCTGSWHS

38

17.8%

NZ_JACHYJ010000001.1:

Lanthipeptides: FHW73_RS02140_lanthipeptide

6

TDCAMCTGSI

15

T+CA CTGSI

31

TNCADCTGSI

40

15.4%

NZ_FOSG01000018.1and 1 other:

NZ_PDKQ02000037.1 Lanthipeptides: BFM75_RS14295_lanthipeptide

Lanthipeptides: BM237_RS22045_lanthipeptide

1

TEIAVTDCAMCTGSIKT

17

T+ T C+ CTGS+ T

33

TDALFTACSSCTGSLTT

49

14.8%

NZ_CP076103.1:

Lanthipeptides: KME82_RS02870_lanthipeptide

4

AVTDCAMCTGSIK

16

A+T C++CTGSI+

37

AITGCSLCTGSIR

49

14.0%

NZ_QSFS01000023.1:

Lanthipeptides: DW924_RS15110_lanthipeptide

6

TDCAMCTGSIKTTK

19

+ CA CTGS K ++

34

SQCAPCTGSSKGSQ

47

KR767_RS20380

Leader:

MIVESMRASQPAGRAAFWRSNACADSPAGALFANEFAEADIVGG

Core:

TDIVVTDCVMCTGSIDARTRHIQCGA

Core with dehydrations:

DhbDIVVDhbDCysVMCysDhbGDhaIDARDhbRHIQCysGA

antiSMASH-DB 4.0 matches for KR767_RS20380

100.0%

NZ_CP077072.1:

Lanthipeptides: KR767_RS20380_lanthipeptide

1

TDIVVTDCVMCTGSIDARTRHIQCGA

26

TDIVVTDCVMCTGSIDARTRHIQCGA

1

TDIVVTDCVMCTGSIDARTRHIQCGA

26

76.9%

NZ_CP095740.1:

Lanthipeptides: L2Y94_RS08180_lanthipeptide

1

TDIVVTDCVMCTGSIDARTRHIQCGA

26

TDI+VT+CV+CTGS+DA TRH+QCGA

1

TDIIVTNCVLCTGSVDANTRHVQCGA

26

61.5%

NZ_FNBR01000006.1and 1 other:

NZ_FUYT01000011.1 Lanthipeptides: B5X73_RS13320_lanthipeptide

Lanthipeptides: BLT40_RS18630_lanthipeptide

1

TDIVVTDCVMCTGSIDARTRHIQCG

25

TD++VTDC MCTGSI T HI C

1

TDMLVTDCAMCTGSIK-NTIHIYCA

24

with 19 more sequence matches

Only the first 10 are displayed here.

57.7%

NZ_CP077072.1:

Lanthipeptides: KR767_RS20375_lanthipeptide

1

TDIVVTDCVMCTGSIDARTRHIQCG

25

T+I VTDC MCTGSI T+ QC

1

TEIAVTDCAMCTGSIKT-TKITQCA

24

42.3%

NZ_CP095740.1:

Lanthipeptides: L2Y94_RS08185_lanthipeptide

1

TDIVVTDCVMCTGSIDARTR

20

T+++VT C MCTGSI+ R

1

TEMLVTGCAMCTGSIEHTIR

20

19.2%

NZ_CGZJ01000010.1and 1 other:

NZ_CRIA01000002.1 Lanthipeptides: AKS83_RS03030_lanthipeptide

Lanthipeptides: AQF97_RS08515_lanthipeptide

12

TGSIDARTRHIQCG

25

TGS + + +++CG

4

TGSYECTSNNVKCG

17

18.8%

NZ_AP023392.1and 8 others:

NZ_CP015557.1 Lanthipeptides: A6M16_RS04825_lanthipeptideNZ_CP065430.1 Lanthipeptides: I5V48_RS05970_lanthipeptideNZ_CP100430.1 Lanthipeptides: NLY76_RS04560_lanthipeptideNZ_JAEUXF010000003.1 Lanthipeptides: JNE40_RS02525_lanthipeptideNZ_VMLD01000009.1 Lanthipeptides: HT679_RS04540_lanthipeptideNZ_VMLI01000004.1 Lanthipeptides: HT696_RS02290_lanthipeptideNZ_VMMD01000015.1 Lanthipeptides: HT711_RS05575_lanthipeptideNZ_VMMI01000027.1 Lanthipeptides: HT721_RS06695_lanthipeptide

Lanthipeptides: H7679_RS04975_lanthipeptide

12

TGSIDARTRHIQCG

25

TGS + + H++CG

19

TGSFECTSNHVKCG

32

18.8%

NZ_CGZJ01000010.1and 15 others:

NZ_CP028436.1 Lanthipeptides: DA395_RS05845_lanthipeptideNZ_CP031248.1 Lanthipeptides: DV130_RS02040_lanthipeptideNZ_CP040803.1 Lanthipeptides: FHI56_RS00865_lanthipeptideNZ_CP090008.1 Lanthipeptides: LV497_RS10155_lanthipeptideNZ_CP113267.1 Lanthipeptides: OTB22_RS04695_lanthipeptideNZ_CRIA01000002.1 Lanthipeptides: AKS83_RS03025_lanthipeptideNZ_FHPK02000016.1 Lanthipeptides: AZ518_RS08970_lanthipeptideNZ_FNJT01000001.1 Lanthipeptides: BLS46_RS03555_lanthipeptideNZ_FZCI01000021.1 Lanthipeptides: CFV25_RS09680_lanthipeptideNZ_JALDWE010000003.1 Lanthipeptides: M1F86_RS04915_lanthipeptideNZ_JUQX01000059.1 Lanthipeptides: ADI74_RS08840_lanthipeptideNZ_LR699783.1 Lanthipeptides: F1569_RS03120_lanthipeptideNZ_NANQ01000004.1 Lanthipeptides: B5K28_RS02515_lanthipeptideNZ_NANU01000009.1 Lanthipeptides: B5K23_RS03060_lanthipeptideNZ_NCUW01000030.1 Lanthipeptides: B7709_RS09425_lanthipeptide

Lanthipeptides: AQF97_RS08510_lanthipeptide

12

TGSIDARTRHIQCG

25

TGS + T +++CG

19

TGSFECTTNNVKCG

32

18.8%

NZ_CP040803.1and 1 other:

NZ_CP090008.1 Lanthipeptides: LV497_RS10150_lanthipeptide

Lanthipeptides: FHI56_RS00860_lanthipeptide

12

TGSIDARTRHIQCG

25

TGS + T +++CG

19

TGSYECTTNNVKCG

32

17.1%

NZ_CP010407.1and 4 others:

NZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptideNZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptideNZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptideNZ_JACHJY010000017.1 Lanthipeptides: GGE06_RS39715_lanthipeptide

Lanthipeptides: SVTN_RS37515_lanthipeptide

1

TDIVVTDCVMCTGSI

15

T+ ++T C CTGS+

22

TEALLTGCSSCTGSL

36

17.1%

NZ_CP029194.1and 1 other:

NZ_CP059991.1 Lanthipeptides: H4W23_RS35675_lanthipeptide

Lanthipeptides: DEJ46_RS04155_lanthipeptide

1

TDIVVTDCVMCTGS

14

T+ ++T C CTGS

22

TEALLTGCSSCTGS

35

17.1%

NZ_JH941044.1:

Lanthipeptides: Y19_RS0126875_lanthipeptide

1

TDIVVTDCVMCTGS

14

T+ + T C CTGS

22

TEALFTGCSSCTGS

35

16.7%

NZ_CP014326.1:

Lanthipeptides: AXK38_RS11340_lanthipeptide

10

MCTGSIDARTRHIQCG

25

+ T S + T H+ CG

21

LFTYSFECSTPHVSCG

36

MIBiG 4.0 matches for KR767_RS20380

15.4%

BGC0000468.5 (CCM09443.1)and 2 others:

BGC0000469.6 (AFV25481.1) Bottromycin: bottromycin A2BGC0001157.6 (CBG72694.1) Bottromycin: bottromycin A2

Bottromycin: bottromycin A2

3

IVVTDC

8

+VV DC

3

VVVFDC

8

11.5%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

6

TDCVMC

11

T C++C

17

TICLVC

22

allorf_4753534_4753761

Leader:

MHPVARKARSYRDCVSLDGYRNDWRQSRCNAIVFA

Core:

GKPRRWVPACAGTTGAIFENISIPKRVRNLVRCVRCLLVR

Core with dehydrations:

GKPRRWVPACysAGDhbDhbGAIFENIDhaIPKRVRNLVRCysVRCysLLVR

antiSMASH-DB 4.0 matches for allorf_4753534_4753761

100.0%

NZ_CP077072.1:

Lanthipeptides: allorf_4753534_4753761_lanthipeptide

1

GKPRRWVPACAGTTGAIFENISIPKRVRNLVRCVRCLLVR

40

GKPRRWVPACAGTTGAIFENISIPKRVRNLVRCVRCLLVR

1

GKPRRWVPACAGTTGAIFENISIPKRVRNLVRCVRCLLVR

40

15.0%

NZ_JAQCXO010000012.1:

Lanthipeptides: PGY55_RS14570_lanthipeptide

10

CAGTTGAIFENISIPK

25

A +G+ FE IP+

7

AARNSGSFFEKRDIPR

22

15.0%

NZ_QGTL01000006.1:

Lanthipeptides: allorf_311998_312129_lanthipeptide

7

VPACAGTT

14

+PACAG+T

11

IPACAGST

18

with 1 more sequence matches

12.5%

NZ_CP078091.1:

Lassopeptides: KVF90_RS04685_lassopeptide

3

PRRWVPACAG

12

P R++P AG

13

PSRYIPGVAG

22

allorf_4755020_4755199

Leader:

MCSVETSAFVGFRSVARARLSASRSARERGG

Core:

ARGDGCGPWRSGLRCPSGKEEPLRGSVF

Core with dehydrations:

ARGDGCysGPWRDhaGLRCysPDhaGKEEPLRGDhaVF

antiSMASH-DB 4.0 matches for allorf_4755020_4755199

100.0%

NZ_CP077072.1:

Lanthipeptides: allorf_4755020_4755199_lanthipeptide

1

ARGDGCGPWRSGLRCPSGKEEPLRGSVF

28

ARGDGCGPWRSGLRCPSGKEEPLRGSVF

1

ARGDGCGPWRSGLRCPSGKEEPLRGSVF

28

36.7%

NZ_CP103871.1and 1 other:

NZ_CP103871.1 Lanthipeptides: NYE86_RS08200_lanthipeptide

Lanthipeptides: NYE86_RS08200_lanthipeptide

1

ARGDGCGPWRSG--LRCPSGKEEP

22

+ GDGCG SG C S E+P

6

STGDGCGSTCSGGASACSSFVEDP

29

32.1%

NZ_CP031264.1and 1 other:

NZ_CP031264.1 Lanthipeptides: C7M71_RS08475_lanthipeptide

Lanthipeptides: C7M71_RS08475_lanthipeptide

4

DGCGPWRSGLRCPSGKEEPL

23

DGCG SG C S ++P+

3

DGCGSSCSGSACTSFTDDPV

22

with 30 more sequence matches

Only the first 10 are displayed here.

32.1%

NZ_JAMTCT010000035.1and 1 other:

NZ_JAMTCT010000035.1 Lanthipeptides: APR04_RS28805_lanthipeptide

Lanthipeptides: APR04_RS28805_lanthipeptide

1

ARGDGCGPWRSGLRCPSGKEEPL

23

+ DGCG S C +GK P

6

STSDGCGSSCSNSACTTGKNTPF

28

32.1%

NZ_KB905816.1and 1 other:

NZ_KB905816.1 Lanthipeptides: F603_RS35860_lanthipeptide

Lanthipeptides: F603_RS35860_lanthipeptide

4

DGCGPWRSGLRCPSGKEEP

22

DGCG SG C S ++P

9

DGCGSTCSGSACNSFTDDP

27

28.6%

NC_013929.1and 11 others:

NC_013929.1 Lanthipeptides: SCAB_RS44850_lanthipeptideNZ_CP024989.1 Lanthipeptides: CVT30_RS13845_lanthipeptideNZ_CP024989.1 Lanthipeptides: CVT30_RS13845_lanthipeptideNZ_CP024989.1 Lanthipeptides: CVT30_RS13845_lanthipeptideNZ_CP043956.1 Lanthipeptides: F3K20_RS28980_lanthipeptideNZ_CP043956.1 Lanthipeptides: F3K20_RS28980_lanthipeptideNZ_CP119182.1 Lanthipeptides: IHE65_RS14995_lanthipeptideNZ_CP119182.1 Lanthipeptides: IHE65_RS14995_lanthipeptideNZ_JABXWH010000012.1 Lanthipeptides: HW845_RS28550_lanthipeptideNZ_JABXWH010000012.1 Lanthipeptides: HW845_RS28550_lanthipeptideNZ_KL997517.1 Lanthipeptides: IQ61_RS45045_lanthipeptide

Lanthipeptides: SCAB_RS44850_lanthipeptide

4

DGCGPWRSGLRCPSGKEEP

22

D CG SG C S +P

8

DNCGSTCSGTACASFTGDP

26

28.6%

NZ_CM001439.1and 5 others:

NZ_CM001439.1 Lanthipeptides: SACMADRAFT_RS20585_lanthipeptideNZ_CP059997.1 Lanthipeptides: HUW46_RS22770_lanthipeptideNZ_CP059997.1 Lanthipeptides: HUW46_RS22770_lanthipeptideNZ_CP090063.1 Lanthipeptides: LWP59_RS37700_lanthipeptideNZ_CP090063.1 Lanthipeptides: LWP59_RS37700_lanthipeptide

Lanthipeptides: SACMADRAFT_RS20585_lanthipeptide

4

DGCGPWRSGLRCPSGKEEPL

23

D CG G C S PL

7

DNCGGTTCGSACTSHVATPL

26

28.6%

NZ_CP054919.1and 1 other:

NZ_CP054919.1 Lanthipeptides: HUT16_RS27255_lanthipeptide

Lanthipeptides: HUT16_RS27255_lanthipeptide

4

DGCGPWRSGLRCPSG

18

DGCG G C SG

9

DGCGSTCEGSACASG

23

28.6%

NZ_CP076538.1and 1 other:

NZ_CP076538.1 Lanthipeptides: KOI47_RS17130_lanthipeptide

Lanthipeptides: KOI47_RS17130_lanthipeptide

4

DGCGPWRSGLRCPSGKEEP

22

DGCG S C S P

9

DGCGQTCSTSACNSQANNP

27

28.6%

NZ_CP113837.1and 1 other:

NZ_CP113837.1 Lanthipeptides: OU787_RS02725_lanthipeptide

Lanthipeptides: OU787_RS02725_lanthipeptide

4

DGCGPWRSGLRCPS

17

DGCG SG C S

9

DGCGSTCSGTACTS

22

28.6%

NZ_KI632511.1and 1 other:

NZ_KI632511.1 Lanthipeptides: ACTRO_RS29755_lanthipeptide

Lanthipeptides: ACTRO_RS29755_lanthipeptide

4

DGCGPWRSGLRCPSGKEEP

22

DGCG S C +G +P

9

DGCGSTCSNSACATGSNDP

27

28.6%

NZ_PGGV01000032.1and 1 other:

NZ_PGGV01000032.1 Lanthipeptides: CUT39_RS12965_lanthipeptide

Lanthipeptides: CUT39_RS12965_lanthipeptide

4

DGCGPWRSGLRCPSGKEEPL

23

DGCG G C S P+

7

DGCGNTCQGSACASFTNNPV

26

28.6%

NZ_PVZV01000003.1and 1 other:

NZ_PVZV01000003.1 Lanthipeptides: C2865_RS14135_lanthipeptide

Lanthipeptides: C2865_RS14135_lanthipeptide

1

ARGDGCGPWRSGLRCPSGKEEPL

23

+ DGCG C SG P+

5

STSDGCGSTCQTSACNSGVANPV

27

allorf_4766677_4766784

Leader:

MRNHVTIAGA

Core:

CKKFPSKRHASVEDMPRPLVNLPQT

Core with dehydrations:

CysKKFPDhaKRHADhaVEDMPRPLVNLPQDhb

antiSMASH-DB 4.0 matches for allorf_4766677_4766784

100.0%

NZ_CP077072.1:

Lanthipeptides: allorf_4766677_4766784_lanthipeptide

1

CKKFPSKRHASVEDMPRPLVNLPQT

25

CKKFPSKRHASVEDMPRPLVNLPQT

1

CKKFPSKRHASVEDMPRPLVNLPQT

25

24.3%

NZ_KB235948.1and 1 other:

NZ_KB235948.1 Lanthipeptides: allorf_4821822_4821968_lanthipeptide

Lanthipeptides: allorf_4821822_4821968_lanthipeptide

1

CKKFPSKRHASVEDMPRP

18

C+K P R S+ D PRP

8

CQKEPRTR--SLADFPRP

23

24.0%

NZ_JAGGRJ010000031.1:

Lanthipeptides: allorf_023920_024030_lanthipeptide

10

ASVEDMPRPLVN

21

A++ED+ RP+ N

2

AAIEDLSRPVWN

13

allorf_4767256_4767366

Leader:

MRHERSRAGA

Core:

LLQRIRTTTPYPCRSAPRARPVERER

Core with dehydrations:

LLQRIRDhbDhbDhbPYPCysRDhaAPRARPVERER

antiSMASH-DB 4.0 matches for allorf_4767256_4767366

100.0%

NZ_CP077072.1:

Lanthipeptides: allorf_4767256_4767366_lanthipeptide

1

LLQRIRTTTPYPCRSAPRARPVERER

26

LLQRIRTTTPYPCRSAPRARPVERER

1

LLQRIRTTTPYPCRSAPRARPVERER

26

38.5%

NZ_CP077072.1:

Lanthipeptides: allorf_2541699_2541854_lanthipeptide

12

PCRSAPRARPV

22

PCRSAPRARP+

6

PCRSAPRARPI

16

23.3%

NZ_SNYR01000002.1:

Lanthipeptides: allorf_843846_843965_lanthipeptide

1

LLQRIRTTTPYPC-RSAPRARPVER

24

L+++IR PC +++P ++R

3

LIEKIRNAGALPCAQTSPEGELIKR

27

with 4 more sequence matches

21.4%

NZ_JADKRR010000001.1:

Lanthipeptides: allorf_2139491_2139706_lanthipeptide

6

RTTTPYPCRSAPRARPVERER

26

RTTT + APRARP R R

32

RTTT----KQAPRARPACRNR

48

21.3%

NZ_LMFT01000038.1:

Lanthipeptides: allorf_010542_010721_lanthipeptide

6

RTTTPYPCRSAPRARPVERER

26

RTT P+P RS+ P R R

23

RTTGPHPPRSSDERSPGPRSR

43

21.1%

NZ_CP026490.1:

Lanthipeptides: allorf_0208403_0208621_lanthipeptide

4

RIRTTTPYPCRSAPRA

19

R+R TT P R P+A

16

RLRATTQVPVRQCPKA

31

12.1%

NZ_JANVAG010000003.1:

Lanthipeptides: allorf_432453_432671_lanthipeptide

13

CRSAPRARPVERE

25

CR P RPV+R

8

CRHLPSQRPVQRH

20

allorf_4771891_4772103

Leader:

MDSFATTGRAQARSYRWECYRRCLSGSGASGHGRAQGA

Core:

LLHWAVSAAISLCCLLQRPGWGSGNLGRFPIH

Core with dehydrations:

LLHWAVDhaAAIDhaLCysCysLLQRPGWGDhaGNLGRFPIH

antiSMASH-DB 4.0 matches for allorf_4771891_4772103

100.0%

NZ_CP077072.1:

Lanthipeptides: allorf_4771891_4772103_lanthipeptide

1

LLHWAVSAAISLCCLLQRPGWGSGNLGRFPIH

32

LLHWAVSAAISLCCLLQRPGWGSGNLGRFPIH

1

LLHWAVSAAISLCCLLQRPGWGSGNLGRFPIH

32

21.9%

NZ_JACSCH020000010.1:

Lanthipeptides: E0F75_RS21605_lanthipeptide

22

GSGNLGRFPIH

32

G+G+LGR PI

2

GAGSLGRAPIR

12

14.0%

NZ_BMUU01000006.1and 2 others:

NZ_BMUZ01000004.1 Lanthipeptides: IE267_RS12230_lanthipeptideNZ_CP070373.1 Lanthipeptides: GWQ54_RS15580_lanthipeptide

Lanthipeptides: IE233_RS19525_lanthipeptide

18

RPGWGSGNLGRFPIH

32

PG SGNL + P+H

16

SPGVASGNLVQIPVH

30

with 1 more sequence matches

13.8%

NZ_CP003987.1:

Lanthipeptides: allorf_00516755_00516991_lanthipeptide

11

SLCCLLQRPGWGSGNLGR

28

S +RPG GSG L R

3

SRATTSRRPGRGSGELAR

20

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.31 out of 18.57

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.33 out of 27.78

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 23.62 out of 29.72

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 20.10 out of 21.84

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.18 out of 20.47

Confidence: medium

Additional weak hits (4):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.70 out of 26.33

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.75 out of 33.14

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.33 out of 36.53

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.43 out of 28.19

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

KR767_RS20375 - Class II

Cleavage pHMM score: -3.10

RODEO score: 0

Monoisotopic mass: 2362.2 Da

Molecular weight: 2363.8 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2381.8 Da N = 1; 2399.8 Da N = 2; 2417.8 Da N = 3; 2435.8 Da N = 4

KR767_RS20380 - Class II

Cleavage pHMM score: -3.10

RODEO score: 0

Monoisotopic mass: 2674.3 Da

Molecular weight: 2676.1 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2694.1 Da N = 1; 2712.1 Da N = 2

allorf_4753534_4753761 - Class II

Cleavage pHMM score: -5.30

RODEO score: 0

Monoisotopic mass: 4450.5 Da

Molecular weight: 4453.4 Da

Number of bridges: 3

allorf_4755020_4755199 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 2919.4 Da

Molecular weight: 2921.3 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2939.3 Da N = 1

allorf_4766677_4766784 - Class II

Cleavage pHMM score: -0.50

RODEO score: 0

Monoisotopic mass: 2823.5 Da

Molecular weight: 2825.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2843.3 Da N = 1; 2861.3 Da N = 2

allorf_4767256_4767366 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 3049.7 Da

Molecular weight: 3051.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3069.5 Da N = 1; 3087.6 Da N = 2; 3105.6 Da N = 3

allorf_4771891_4772103 - Class II

Cleavage pHMM score: -7.20

RODEO score: 0

Monoisotopic mass: 3417.8 Da

Molecular weight: 3420.0 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3438.0 Da N = 1

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MexT	Global virulence regulator
NtrC	Nitrogen regulatory protein C
ToxT	Regulator of MSHA biosynthesis
VqsM	Regulator of quorum-sensing signalling systems