Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
1.10
1.11
1.12
1.13
1.14

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP077072.1 (Luteibacter anthropi)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | redox-cofactor | 76,912 | 99,056 |  |
Region 2 | terpene-precursor | 397,041 | 417,943 |
Region 3 | RiPP-like | 1,135,499 | 1,146,335 |  |
Region 4 | lanthipeptide-class-iii | 1,332,088 | 1,354,808 |
Region 5 | arylpolyene | 1,817,048 | 1,858,238 | Low | xanthomonadin I | other:other
Region 6 | RiPP-like | 2,138,152 | 2,151,448 |
Region 7 | lanthipeptide-class-ii | 2,267,382 | 2,290,318 |
Region 8 | lanthipeptide-class-ii | 2,536,572 | 2,559,448 |
Region 9 | NRPS | 2,825,728 | 2,897,422 | High | rhizomide A/rhizomide B/rhizomide C | NRPS:Type I
Region 10 | NRPS,T1PKS | 3,682,473 | 3,735,023 |  |
Region 11 | NI-siderophore | 3,880,425 | 3,913,098 | High | xanthoferrin | other:other
Region 12 | NRP-metallophore,NRPS | 4,117,764 | 4,182,637 | Low | pyochelin | NRPS:Type I
Region 13 | T1PKS | 4,502,945 | 4,548,698 |  |
Region 14 | lanthipeptide-class-ii | 4,753,378 | 4,776,317 |

NZ_CP077072.1 - Region 1 - redox-cofactor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 76,912 - 99,056 nt. (total: 22,145 nt) Show pHMM detection rules used
redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | redox-cofactor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001485.4 |  | 0.40 | other (other) | chuangxinmycin | Actinoplanes tsinanensis
BGC0001100.5 |  | 0.34 | NRPS, PKS | lankacidin C | Streptomyces rochei
BGC0001440.5 |  | 0.34 | other (other) | cystargolide A, cystargolide B | Kitasatospora cystarginea
BGC0002138.2 |  | 0.32 | PKS | fuelimycin A, fuelimicin B, fuelimicin C | Streptomyces albireticuli NRRL B-1670
BGC0001441.5 |  | 0.32 | other (other) | belactosin A, belactosin C | Streptomyces sp.
BGC0002060.3 |  | 0.29 | PKS | secimide | Pseudomonas syringae pv. syringae B728a
BGC0002496.3 |  | 0.28 | NRPS | serratiochelin A, serratiochelin C, serratiochelin B | Serratia plymuthica
BGC0001019.5 |  | 0.27 | NRPS, PKS | microsclerodermin M | Sorangium cellulosum
BGC0002359.3 |  | 0.26 | NRPS | dudomycin A | Streptomyces albus subsp. chlorinus
BGC0002282.2 |  | 0.26 | other (other) | formycin A | Streptomyces kaniharaensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001485.4 |  | 0.40 | other (other) | chuangxinmycin | Actinoplanes tsinanensis
BGC0001100.5 |  | 0.34 | NRPS, PKS | lankacidin C | Streptomyces rochei
BGC0001440.5 |  | 0.34 | other (other) | cystargolide A, cystargolide B | Kitasatospora cystarginea
BGC0002138.2 |  | 0.32 | PKS | fuelimycin A, fuelimicin B, fuelimicin C | Streptomyces albireticuli NRRL B-1670
BGC0001441.5 |  | 0.32 | other (other) | belactosin A, belactosin C | Streptomyces sp.
BGC0002060.3 |  | 0.29 | PKS | secimide | Pseudomonas syringae pv. syringae B728a
BGC0002496.3 |  | 0.28 | NRPS | serratiochelin A, serratiochelin C, serratiochelin B | Serratia plymuthica
BGC0001019.5 |  | 0.27 | NRPS, PKS | microsclerodermin M | Sorangium cellulosum
BGC0002359.3 |  | 0.26 | NRPS | dudomycin A | Streptomyces albus subsp. chlorinus
BGC0002282.2 |  | 0.26 | other (other) | formycin A | Streptomyces kaniharaensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.31 out of 18.46
Confidence: strong
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 26.42 out of 29.72
Confidence: strong
Additional weak hits (3):
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.35 out of 36.53
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.86 out of 23.43
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.03 out of 29.65
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

redox-cofactor protocluster (76911...99056)
KR767_RS00430
  RRE type: PqqD_RRE
  Location: 0 - 86
  Score: 111.3

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
NtrC | Nitrogen regulatory protein C
RpoN | Regulator of nitrogen assimilation and virulence

NZ_CP077072.1 - Region 2 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 397,041 - 417,943 nt. (total: 20,903 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: transferase
KR767_RS01850: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Ligases: synthetase
KR767_RS01880: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000630.3 |  | 0.36 | terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000646.5 |  | 0.35 | terpene | β-carotein | uncultured bacterium
BGC0000641.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC416
BGC0000639.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.34 | terpene | carotenoid | Pantoea ananatis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000630.3 |  | 0.36 | terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000646.5 |  | 0.35 | terpene | β-carotein | uncultured bacterium
BGC0000641.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC416
BGC0000639.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.34 | terpene | carotenoid | Pantoea ananatis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
KR767_RS01880: PT_FPPS_like
Domain 1 (36 - 298): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.76 out of 27.55
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.16 out of 26.33
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.95 out of 20.97
Confidence: medium
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52
Confidence: strong
Additional weak hits (3):
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.96 out of 26.33
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.11 out of 25.75
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.21 out of 28.19
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
AbrC3 | Antibiotic production activator
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
CcpA | Catabolite control protein A
GnfM | Regulator of nitrogen-fixation genes

NZ_CP077072.1 - Region 3 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,135,499 - 1,146,335 nt. (total: 10,837 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002133.3 |  | 0.43 | ribosomal | group 1 methanobactin | Methylosinus sp. LW3
BGC0000527.5 |  | 0.39 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000043.5 |  | 0.39 | PKS | curacin A | Moorea producens 19L
BGC0000589.5 |  | 0.39 | ribosomal | microcin M | Escherichia coli Nissle 1917
BGC0002116.3 |  | 0.38 | ribosomal | darobactin A | Photorhabdus khanii HGB 1456
BGC0002571.2 |  | 0.38 | NRPS | pyoverdine DC3000 | Pseudomonas syringae pv. tomato str. DC3000
BGC0002447.3 |  | 0.37 | ribosomal | cerecyclin | Bacillus cereus
BGC0002442.3 |  | 0.36 | ribosomal | toyoncin | Bacillus toyonensis
BGC0000487.5 |  | 0.36 | ribosomal | carnocyclin | Carnobacterium maltaromaticum
BGC0001727.3 |  | 0.36 | ribosomal | paenilan | Paenibacillus polymyxa E681

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002133.3 |  | 0.43 | ribosomal | group 1 methanobactin | Methylosinus sp. LW3
BGC0000527.5 |  | 0.39 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000043.5 |  | 0.39 | PKS | curacin A | Moorea producens 19L
BGC0000589.5 |  | 0.39 | ribosomal | microcin M | Escherichia coli Nissle 1917
BGC0002116.3 |  | 0.38 | ribosomal | darobactin A | Photorhabdus khanii HGB 1456
BGC0002571.2 |  | 0.38 | NRPS | pyoverdine DC3000 | Pseudomonas syringae pv. tomato str. DC3000
BGC0002447.3 |  | 0.37 | ribosomal | cerecyclin | Bacillus cereus
BGC0002442.3 |  | 0.36 | ribosomal | toyoncin | Bacillus toyonensis
BGC0000487.5 |  | 0.36 | ribosomal | carnocyclin | Carnobacterium maltaromaticum
BGC0001727.3 |  | 0.36 | ribosomal | paenilan | Paenibacillus polymyxa E681

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.15 out of 27.55
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.08 out of 28.19
Confidence: medium
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
GnfM | Regulator of nitrogen-fixation genes
ZuR variant 1 | Zinc-responsive repressor

NZ_CP077072.1 - Region 4 - lanthipeptide-class-iii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,332,088 - 1,354,808 nt. (total: 22,721 nt) Show pHMM detection rules used
lanthipeptide-class-iii: (micKC and not PKS_KS)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Isomerases: mutase
KR767_RS06100: phosphoglycerate mutase

smcogs
  SMCOG1101: phosphoglycerate mutase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-iii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002337.2 |  | 0.56 | ribosomal | class IV lanthipeptide, SflA | Streptomyces sp. NRRL S-1022
BGC0002700.2 |  | 0.51 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000519.4 |  | 0.51 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000496.5 |  | 0.51 | ribosomal | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000513.3 |  | 0.49 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000553.3 |  | 0.48 | ribosomal | SRO15-2212 | Streptomyces filamentosus NRRL 15998
BGC0002111.3 |  | 0.48 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0002701.2 |  | 0.40 | ribosomal | paenithipeptin | Paenibacillus thiaminolyticus
BGC0002116.3 |  | 0.38 | ribosomal | darobactin A | Photorhabdus khanii HGB 1456
BGC0002447.3 |  | 0.37 | ribosomal | cerecyclin | Bacillus cereus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002337.2 |  | 0.56 | ribosomal | class IV lanthipeptide, SflA | Streptomyces sp. NRRL S-1022
BGC0002700.2 |  | 0.51 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000519.4 |  | 0.51 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000496.5 |  | 0.51 | ribosomal | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000513.3 |  | 0.49 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000553.3 |  | 0.48 | ribosomal | SRO15-2212 | Streptomyces filamentosus NRRL 15998
BGC0002111.3 |  | 0.48 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0002701.2 |  | 0.40 | ribosomal | paenithipeptin | Paenibacillus thiaminolyticus
BGC0002116.3 |  | 0.38 | ribosomal | darobactin A | Photorhabdus khanii HGB 1456
BGC0002447.3 |  | 0.37 | ribosomal | cerecyclin | Bacillus cereus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
Lanthipeptides - No core peptides found.
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46
Confidence: strong
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.64 out of 27.55
Confidence: medium
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 22.05 out of 22.40
Confidence: strong
Additional weak hits (7):
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.21 out of 26.33
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.57 out of 26.33
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.52 out of 18.57
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.81 out of 21.55
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.76 out of 30.25
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.31 out of 27.78
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.85 out of 20.01
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
GnfM | Regulator of nitrogen-fixation genes
HypR | L-hydroxyproline utilization repressor
RpoN | Regulator of nitrogen assimilation and virulence

NZ_CP077072.1 - Region 5 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,817,048 - 1,858,238 nt. (total: 41,191 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: transferase
KR767_RS08185: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Hydrolases: peptidase
KR767_RS08280: methionine aminopeptidase

smcogs
  SMCOG1172: methionine aminopeptidase

Isomerases: mutase
KR767_RS08255: phosphoglycerate mutase

smcogs
  SMCOG1101: phosphoglycerate mutase

Ligases: synthase
KR767_RS08225: polyprenol-monophosphomannose synthase ppm1

smcogs
  SMCOG1123: polyprenol-monophosphomannose synthase ppm1

KR767_RS08235: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001160.5 |  | 0.55 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001164.3 |  | 0.54 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001217.5 |  | 0.50 | other (other) | PreQ0 Base | Streptomyces qinglanensis
BGC0000840.5 |  | 0.49 | other (other) | xanthomonadin I | Xanthomonas oryzae pv. oryzae
BGC0000013.3 |  | 0.43 | PKS | alternariol | Aspergillus nidulans FGSC A4
BGC0002008.3 |  | 0.43 | other (other) | aryl polyenes | Xenorhabdus doucetiae
BGC0001400.3 |  | 0.43 | PKS | citreoviridin | Aspergillus terreus NIH2624
BGC0000836.5 |  | 0.43 | other (other) | APE Ec | Escherichia coli CFT073
BGC0001987.2 |  | 0.42 | PKS | koreenceine A, koreenceine B, koreenceine C, koreenceine D | Pseudomonas koreensis
BGC0000837.4 |  | 0.40 | other (other) | APE Vf | Aliivibrio fischeri ES114

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001160.5 |  | 0.55 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001164.3 |  | 0.54 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001217.5 |  | 0.50 | other (other) | PreQ0 Base | Streptomyces qinglanensis
BGC0000840.5 |  | 0.49 | other (other) | xanthomonadin I | Xanthomonas oryzae pv. oryzae
BGC0000013.3 |  | 0.43 | PKS | alternariol | Aspergillus nidulans FGSC A4
BGC0002008.3 |  | 0.43 | other (other) | aryl polyenes | Xenorhabdus doucetiae
BGC0001400.3 |  | 0.43 | PKS | citreoviridin | Aspergillus terreus NIH2624
BGC0000836.5 |  | 0.43 | other (other) | APE Ec | Escherichia coli CFT073
BGC0001987.2 |  | 0.42 | PKS | koreenceine A, koreenceine B, koreenceine C, koreenceine D | Pseudomonas koreensis
BGC0000837.4 |  | 0.40 | other (other) | APE Vf | Aliivibrio fischeri ES114

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.99 out of 20.47
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16
Confidence: strong
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.60 out of 23.79
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.38 out of 23.79
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.21 out of 23.79
Confidence: medium
Additional weak hits (10):
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.46 out of 27.55
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 18.63 out of 30.97
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.82 out of 32.93
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.07 out of 29.65
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.79 out of 22.40
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.12 out of 21.84
Confidence: weak
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 23.42 out of 32.38
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.50 out of 32.93
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.06 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 18.90 out of 33.14
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
IolR | Regulator of the inositol catabolism
VqsM | Regulator of quorum-sensing signalling systems

NZ_CP077072.1 - Region 6 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,138,152 - 2,151,448 nt. (total: 13,297 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001285.5 |  | 0.26 | other (fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0002788.2 |  | 0.20 | PKS | 14-hydroxyisochainin | Streptomyces peucetius subsp. caesius ATCC 27952

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001285.5 |  | 0.26 | other (fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0002788.2 |  | 0.20 | PKS | 14-hydroxyisochainin | Streptomyces peucetius subsp. caesius ATCC 27952

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.79 out of 21.84
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26
Confidence: medium
Additional weak hits (5):
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 20.79 out of 30.97
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.94 out of 19.52
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.77 out of 27.55
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.33 out of 27.04
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.50 out of 30.98
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
CRP | Cyclic AMP receptor protein
MexT | Global virulence regulator

NZ_CP077072.1 - Region 7 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,267,382 - 2,290,318 nt. (total: 22,937 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: dehalogenase
KR767_RS10115: haloalkane dehalogenase

smcogs
  SMCOG1262: haloalkane dehalogenase

Lyases: cyclase
KR767_RS10080: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001579.4 |  | 0.49 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0000528.5 |  | 0.48 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002698.2 |  | 0.46 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0001210.5 |  | 0.45 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000503.5 |  | 0.45 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0002346.3 |  | 0.43 | ribosomal | kyamicin | Saccharopolyspora sp.
BGC0000527.5 |  | 0.42 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000517.4 |  | 0.41 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001364.3 |  | 0.39 | ribosomal | cinnamycin B | Actinomadura atramentaria DSM 43919
BGC0001863.4 |  | 0.38 | ribosomal, terpene | bacillicn CER074 | Bacillus mycoides

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001579.4 |  | 0.49 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0000528.5 |  | 0.48 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002698.2 |  | 0.46 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0001210.5 |  | 0.45 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000503.5 |  | 0.45 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0002346.3 |  | 0.43 | ribosomal | kyamicin | Saccharopolyspora sp.
BGC0000527.5 |  | 0.42 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000517.4 |  | 0.41 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001364.3 |  | 0.39 | ribosomal | cinnamycin B | Actinomadura atramentaria DSM 43919
BGC0001863.4 |  | 0.38 | ribosomal, terpene | bacillicn CER074 | Bacillus mycoides

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for KR767_RS10080

KR767_RS10085
Leader:
MQTDKILAGWLSGADSVGG
Core:
Y D N P A G S L Y T E G L A K T M N A M T N P E V A I G T N C S S C T A S R P G F C C
Core with dehydrations:
Y D N P A G Dha L Y Dhb E G L A K Dhb M N A M Dhb N P E V A I G Dhb N Cys Dha Dha Cys Dhb A Dha R P G F Cys Cys

#### antiSMASH-DB 4.0 matches for KR767_RS10085

100.0%
NZ_CP077072.1:
Lanthipeptides: KR767_RS10085_lanthipeptide
1
Y D N P A G S L Y T E G L A K T M N A M T N P E V A I G T N C S S C T A S R P G F C C
43
Y D N P A G S L Y T E G L A K T M N A M T N P E V A I G T N C S S C T A S R P G F C C
1
Y D N P A G S L Y T E G L A K T M N A M T N P E V A I G T N C S S C T A S R P G F C C
43
79.1%
NZ_CP095741.1:
Lanthipeptides: L2Y96_RS03630_lanthipeptide
1
Y D N P A G S L Y T E G L A K T M N A M T N P E V A I G T N C S S C T A S R P G F C C
43
Y D N P A G S L Y T E G A+T M A M T N E+A+ +N C S S C T A S R P G C C
1
Y D N P A G S L Y T E G Q A Q T M V A M T N A E M A L A S N C S S C T A S R P G L C C
43
74.4%
NZ_CP095742.1:
Lanthipeptides: L2Y97_RS03060_lanthipeptide
1
Y D N P A G S L Y T E G L A K T M N A M T N P E V A I G T N C S S C T A S R P G F C C
43
Y D N P A G S L Y T E G +T M A M N E+A+ +N C S S C T A S R P G C C
1
Y D N P A G S L Y T E G Q T Q T M A A M V N A E M A L A S N C S S C T A S R P G L C C
43
with 61 more sequence matches
Only the first 10 are displayed here.
72.1%
NZ_JAAOYX010000001.1:
Lanthipeptides: FHS47_RS11835_lanthipeptide
1
Y D N P A G S L Y T E G L A K T M N A M T N P E V A I G T N C S S C T A S R P G F C C
43
Y D N P A G S L Y T E G A+T+ A M T+ ++A+ +N C S S C T A S R P G C C
1
Y D N P A G S L Y T E G H A Q T V M A M T S T D I A L V S N C S S C T A S R P G V C C
43
54.7%
NZ_CP063231.1 and 1 other:
NZ_FPIS01000001.1 Lanthipeptides: BT115_RS02490_lanthipeptide
Lanthipeptides: IM816_RS09045_lanthipeptide
1
Y D N P A G S L Y T E G L A K T M N A M T N P E V A I G T N C S S C T A S R P G F C C
43
Y D N P A G L Y T E G +T+ A M T+ ++A+ +N C S S C T A S R P G C C
11
Y D N P A G P L Y T E G H N Q T L M A M T S T D I A L I S N C S S C T A S R P G V C C
53
48.8%
NZ_CP010407.1 and 4 others:
NZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptide NZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptide NZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptide NZ_JACHJY010000017.1 Lanthipeptides: GGE06_RS39715_lanthipeptide
Lanthipeptides: SVTN_RS37515_lanthipeptide
2
D N P A G S L Y T E G L A K T M N A M T N P E V A I G T N C S S C T A S R P G F C C
43
D N P A G L Y G A A+T+ A+ T C S S C T S +C C
1
D N P A G P L Y V G G A A G E A-A L T D G T E A L L T G C S S C T G S L H S Y C C
41
48.8%
NZ_CP029194.1 and 1 other:
NZ_CP059991.1 Lanthipeptides: H4W23_RS35675_lanthipeptide
Lanthipeptides: DEJ46_RS04155_lanthipeptide
2
D N P A G S L Y T E G L A K T M N A M T N P E V A I G T N C S S C T A S R P G F C C
43
D N P A G L Y G A A+T+ A+ T C S S C T S +C C
1
D N P A G P L Y V G G A A G E A-A L T D A T E A L L T G C S S C T G S W H S Y C C
41
48.8%
NZ_CP069396.1:
Lanthipeptides: JRI60_RS03735_lanthipeptide
3
N P A G S L Y T E G L A K T M N A M T N P E V A I G T N C S S C T A S R P G F C C
43
N P A G L Y G A T N A+T+ A+ T C S S C+ S +C C
2
N P A G P L Y V G G-A A T E N A L T D A S D A L V T R C S S C S G S A G S Y C C
41
48.8%
NZ_JH941044.1:
Lanthipeptides: Y19_RS0126875_lanthipeptide
2
D N P A G S L Y T E G L A K T M N A M T N P E V A I G T N C S S C T A S R P G F C C
43
D N P A G L Y G A A+T+ A+ T C S S C T S +C C
1
D N P A G P L Y V G G A A G E A-A L T D A T E A L F T G C S S C T G S W H S Y C C
41
47.2%
NZ_CP093340.1:
Lanthipeptides: MNO14_RS04685_lanthipeptide
1
Y D N P A G S L Y T E G L A K T M N A M T N P E V A I G T N C S S C T A S R P G F C C
43
Y+N P A G+L Y E G+A T A M T+ + T C S S C T A S P C C
11
Y E N P A G A L Y V E G I A A T E A A M T D K S F L L L T Q C S S C T A S I P A H C C
53
46.5%
NZ_CP034669.1:
Lanthipeptides: EJ065_RS19470_lanthipeptide
3
N P A G S L Y T E G L A K T M N A M T N P E V A I G T N C S S C T A S R P G F C C
43
N P A G ++ G L +T A+T + T C S S C+A S G F C C
2
N P A G P V F V G G L-R T E Q A L T E S N L V E N T G C S S C S A S T T G F C C
41
44.2%
NZ_CP012109.1:
Lanthipeptides: A176_RS31295_lanthipeptide
3
N P A G S L Y T E G L A K T M N A M T N P E V A I G T N C S S C T A S R P G F C C
43
N P A G L Y G A T A+T+ + I T C S S C+A S G F C C
13
N P A G P L Y V G G D A-T E A A L T D E S L M I F T G C S S C S A S G T G F C C
52
44.2%
NZ_CP071090.1:
Lanthipeptides: JY651_RS36970_lanthipeptide
3
N P A G S L Y T E G L A K T M N A M T N P E V A I G T N C S S C T A S R P G F C C
43
N P A G L Y G A T A+T+ +G T C S C T A S R P C C
13
N P A G P L Y V G G T A-T E A A L T D A A P M M G T G C S I C T A S R P V V C C
52

#### MIBiG 4.0 matches for KR767_RS10085

11.6%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
26
A I G T N C S S C T A S R
38
A+G N C T ++
11
A L G N N G G W C T L T K
23
allorf_2267459_2267614
Leader:
MHDETREGG
Core:
S C P S F V L L G R G C D Q S R F V D A A L Q G R Y R V P H K H L S F S R S K G H L
Core with dehydrations:
Dha Cys P Dha F V L L G R G Cys D Q Dha R F V D A A L Q G R Y R V P H K H L Dha F Dha R Dha K G H L

#### antiSMASH-DB 4.0 matches for allorf_2267459_2267614

100.0%
NZ_CP077072.1:
Lanthipeptides: allorf_2267459_2267614_lanthipeptide
1
S C P S F V L L G R G C D Q S R F V D A A L Q G R Y R V P H K H L S F S R S K G H L
42
S C P S F V L L G R G C D Q S R F V D A A L Q G R Y R V P H K H L S F S R S K G H L
1
S C P S F V L L G R G C D Q S R F V D A A L Q G R Y R V P H K H L S F S R S K G H L
42
allorf_2268058_2268276
Leader:
MAHGTSCADMFKLIIFHELMAMLWA
Core:
A C M T M I V V L I Y P G Y G A I W K V F L F W G A L A Q V L V A L R V A M D R R K R R A N H
Core with dehydrations:
A Cys M Dhb M I V V L I Y P G Y G A I W K V F L F W G A L A Q V L V A L R V A M D R R K R R A N H

#### antiSMASH-DB 4.0 matches for allorf_2268058_2268276

100.0%
NZ_CP077072.1:
Lanthipeptides: allorf_2268058_2268276_lanthipeptide
1
A C M T M I V V L I Y P G Y G A I W K V F L F W G A L A Q V L V A L R V A M D R R K R R A N H
47
A C M T M I V V L I Y P G Y G A I W K V F L F W G A L A Q V L V A L R V A M D R R K R R A N H
1
A C M T M I V V L I Y P G Y G A I W K V F L F W G A L A Q V L V A L R V A M D R R K R R A N H
47
allorf_2268112_2268327
Leader:
MHASLAHLHAG
Core:
D K C N H F S V I R P S L P S I H G H P K R H Q H L G Q R A P E K K H L P D G P V T R V D E Y D N H R H A C S P E H G H
Core with dehydrations:
D K Cys N H F Dha V I R P Dha L P Dha I H G H P K R H Q H L G Q R A P E K K H L P D G P V Dhb R V D E Y D N H R H A Cys Dha P E H G H

#### antiSMASH-DB 4.0 matches for allorf_2268112_2268327

100.0%
NZ_CP077072.1:
Lanthipeptides: allorf_2268112_2268327_lanthipeptide
1
D K C N H F S V I R P S L P S I H G H P K R H Q H L G Q R A P E K K H L P D G P V T R V D E Y D N H R H A C S P E H G H
60
D K C N H F S V I R P S L P S I H G H P K R H Q H L G Q R A P E K K H L P D G P V T R V D E Y D N H R H A C S P E H G H
1
D K C N H F S V I R P S L P S I H G H P K R H Q H L G Q R A P E K K H L P D G P V T R V D E Y D N H R H A C S P E H G H
60
10.0%
NZ_CP099547.1:
Lanthipeptides: allorf_0569907_0570044_lanthipeptide
7
S V I R P S L P S I H G H P
20
S++R P+L ++ G P
10
S L V R P A L G A L G G S P
23
allorf_2268889_2269032
Leader:
MPFSAMRRGTHAAS
Core:
H R M R R R S L V R L A C H R I H Q D G P V H L P R G S E I S G N
Core with dehydrations:
H R M R R R Dha L V R L A Cys H R I H Q D G P V H L P R G Dha E I Dha G N

#### antiSMASH-DB 4.0 matches for allorf_2268889_2269032

100.0%
NZ_CP077072.1:
Lanthipeptides: allorf_2268889_2269032_lanthipeptide
1
H R M R R R S L V R L A C H R I H Q D G P V H L P R G S E I S G N
33
H R M R R R S L V R L A C H R I H Q D G P V H L P R G S E I S G N
1
H R M R R R S L V R L A C H R I H Q D G P V H L P R G S E I S G N
33
24.2%
NZ_CP116936.1:
Lanthipeptides: allorf_2855879_2856049_lanthipeptide
11
L A C H R I H Q D G P V H L P R G S E
29
+A C R H P H R +E
6
V A C S R S H P Q P P P H H Q R S A E
24
18.2%
NZ_FNPT01000004.1:
Lanthipeptides: allorf_361247_361429_lanthipeptide
13
C H R I H Q D G P V H L P R G
27
C I Q G P P R G
30
C D E I E Q S G P A A Q P R G
44
with 4 more sequence matches
18.2%
NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: allorf_0444250_0444393_lanthipeptide
Lanthipeptides: allorf_0444250_0444393_lanthipeptide
4
R R R S L V R L A C H R I H Q
18
R R R L L C ++
1
R R R E L F S L K C K E F Y E
15
16.7%
NZ_CP064030.1:
Lanthipeptides: allorf_1950344_1950583_lanthipeptide
7
S L V R L A C H R I H Q D G P V H L P R G
27
S R C+R G V H G
15
S A T R T Q C Y R Y R N A G K V H G K T G
35
15.2%
NZ_KZ454939.1:
Lanthipeptides: allorf_0215974_0216129_lanthipeptide
16
I H Q D G P V H
23
++Q D P V H
2
V N Q D S P V H
9
10.7%
NZ_KB900614.1:
Lanthipeptides: allorf_2973181_2973414_lanthipeptide
4
R R R S L V R L A C H R I H Q
18
R R + C R+H Q
15
R R A G W I T E G C Q R V H Q
29
allorf_2272776_2272946
Leader:
MCRSDMSAKCLLANRKILLEDVAGL
Core:
V R L L Q V R A L R A T G C R V E P V A R K A R S Y M A S V T
Core with dehydrations:
V R L L Q V R A L R A Dhb G Cys R V E P V A R K A R Dha Y M A Dha V Dhb

#### antiSMASH-DB 4.0 matches for allorf_2272776_2272946

100.0%
NZ_CP077072.1:
Lanthipeptides: allorf_2272776_2272946_lanthipeptide
1
V R L L Q V R A L R A T G C R V E P V A R K A R S Y M A S V T
31
V R L L Q V R A L R A T G C R V E P V A R K A R S Y M A S V T
1
V R L L Q V R A L R A T G C R V E P V A R K A R S Y M A S V T
31
19.4%
NZ_CP069338.1:
Lanthipeptides: allorf_01719481_01719645_lanthipeptide
5
Q V R A L R A T G C R
15
+ R A L T G C+
2
K W R A L H P T G C Q
12
allorf_2273844_2273954
Leader:
MPPSEHIAIPFS
Core:
L P I S R E N T R C P P I S T R L D D C C E C S
Core with dehydrations:
L P I Dha R E N Dhb R Cys P P I Dha Dhb R L D D Cys Cys E Cys Dha

#### antiSMASH-DB 4.0 matches for allorf_2273844_2273954

100.0%
NZ_CP077072.1:
Lanthipeptides: allorf_2273844_2273954_lanthipeptide
1
L P I S R E N T R C P P I S T R L D D C C E C S
24
L P I S R E N T R C P P I S T R L D D C C E C S
1
L P I S R E N T R C P P I S T R L D D C C E C S
24
29.2%
NZ_QKUF01000002.1:
Lanthipeptides: EI42_RS32305_lanthipeptide
14
S T R L D D C C E C S
24
S T +D D C C S
2
S T G I D D S C S C S
12
25.0%
NZ_CP090100.1 and 3 others:
NZ_SIJR01000001.1 Lanthipeptides: allorf_2033312_2033491_lanthipeptide NZ_SIKP01000006.1 Lanthipeptides: allorf_320758_320937_lanthipeptide NZ_SIMU01000019.1 Lanthipeptides: allorf_19855_20034_lanthipeptide
Lanthipeptides: allorf_349430_349609_lanthipeptide
9
R C P P I S T R L
17
R P P I S R L
11
R T P P I S R R L
19
with 2 more sequence matches
25.0%
NZ_LT607733.1:
Lanthipeptides: GA0070610_RS30575_lanthipeptide
11
P P I S T R L D D C C E C
23
P P I + C C C
2
P P I D G H T E K C C H C
14
21.6%
NZ_CP069396.1 and 1 other:
NZ_CP069396.1 Lanthipeptides: allorf_03493802_03493966_lanthipeptide
Lanthipeptides: allorf_03493802_03493966_lanthipeptide
2
P I S R E N T R C P P I S T R L D D C C
21
P+S C P S+R D C
5
P L S A S A P V C G P S S S R F D S P C
24

#### MIBiG 4.0 matches for allorf_2273844_2273954

16.7%
BGC0001155.5 (AGY49587.1):
Thiopeptide: GE2270
20
C C E C S
24
C C C S
9
C C S C S
13
allorf_2280552_2280674
Leader:
MGLRPEREGRASQRA
Core:
L L R R R H R T I L K S P G Q R H G R T C R I Y M
Core with dehydrations:
L L R R R H R Dhb I L K Dha P G Q R H G R Dhb Cys R I Y M

#### antiSMASH-DB 4.0 matches for allorf_2280552_2280674

100.0%
NZ_CP077072.1:
Lanthipeptides: allorf_2280552_2280674_lanthipeptide
1
L L R R R H R T I L K S P G Q R H G R T C R I Y M
25
L L R R R H R T I L K S P G Q R H G R T C R I Y M
1
L L R R R H R T I L K S P G Q R H G R T C R I Y M
25
36.0%
NZ_CAOJCM010000001.1:
Lanthipeptides: allorf_0381374_0381505_lanthipeptide
9
I L K S P G Q R H G R T C R I
23
I L K+ G R H +C R I
1
I L K A K G N R H--S C R I
13
24.0%
NZ_CP101417.1:
Lanthipeptides: allorf_0369305_0369400_lanthipeptide
13
P G Q R H G R T C R I
23
P H G R T C +
4
P P S L H G R T C G V
14
with 2 more sequence matches
17.1%
NZ_LUCO01000016.1:
Lanthipeptides: BMBG_RS27150_lanthipeptide
4
R R H R T I L K S P G Q R H G R T C R I
23
+ L G +G R T C +
6
S K Q A A N L T G L G N N Y G R T C T L
25
13.7%
NC_019779.1:
Lanthipeptides: allorf_0212589_0212804_lanthipeptide
7
R T I L K S P G Q R H G R T C R I
23
R ++K P R H G R+
29
R C L V K H P D I R H G S A F R V
45
allorf_2285440_2285562
Leader:
MPLVIQDDISAG
Core:
H C D K T P G Y M I D P H R S A S F S M R H R L Q S P I
Core with dehydrations:
H Cys D K Dhb P G Y M I D P H R Dha A Dha F Dha M R H R L Q Dha P I

#### antiSMASH-DB 4.0 matches for allorf_2285440_2285562

100.0%
NZ_CP077072.1:
Lanthipeptides: allorf_2285440_2285562_lanthipeptide
1
H C D K T P G Y M I D P H R S A S F S M R H R L Q S P I
28
H C D K T P G Y M I D P H R S A S F S M R H R L Q S P I
1
H C D K T P G Y M I D P H R S A S F S M R H R L Q S P I
28

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.03 out of 29.72
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.99 out of 20.47
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.06 out of 28.19
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05
Confidence: medium
Additional weak hits (8):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.87 out of 29.38
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.91 out of 27.78
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.16 out of 21.55
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.99 out of 27.55
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.26 out of 20.01
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.26 out of 18.57
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.23 out of 20.01
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

KR767_RS10085 - Class II
  Cleavage pHMM score: -4.00
  RODEO score: 0
  Monoisotopic mass: 4282.9 Da
  Molecular weight: 4285.8 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4303.8 Da N = 1
    4321.8 Da N = 2
    4339.8 Da N = 3
    4357.9 Da N = 4
    4375.9 Da N = 5
allorf_2267459_2267614 - Class II
  Cleavage pHMM score: -4.40
  RODEO score: 0
  Monoisotopic mass: 4603.4 Da
  Molecular weight: 4606.2 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4624.3 Da N = 1
    4642.3 Da N = 2
    4660.3 Da N = 3
    4678.3 Da N = 4
allorf_2268058_2268276 - Class II
  Cleavage pHMM score: -1.30
  RODEO score: 0
  Monoisotopic mass: 5385.0 Da
  Molecular weight: 5388.5 Da
  Number of bridges: 1
allorf_2268112_2268327 - Class II
  Cleavage pHMM score: -4.70
  RODEO score: 0
  Monoisotopic mass: 6800.4 Da
  Molecular weight: 6804.5 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    6822.5 Da N = 1
    6840.5 Da N = 2
    6858.5 Da N = 3
allorf_2268889_2269032 - Class II
  Cleavage pHMM score: -6.70
  RODEO score: 0
  Monoisotopic mass: 3786.0 Da
  Molecular weight: 3788.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3806.3 Da N = 1
    3824.4 Da N = 2
allorf_2272776_2272946 - Class II
  Cleavage pHMM score: -6.10
  RODEO score: 0
  Monoisotopic mass: 3384.9 Da
  Molecular weight: 3387.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3405.0 Da N = 1
    3423.1 Da N = 2
    3441.1 Da N = 3
allorf_2273844_2273954 - Class II
  Cleavage pHMM score: -6.00
  RODEO score: 0
  Monoisotopic mass: 2617.2 Da
  Molecular weight: 2619.0 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2637.0 Da N = 1
allorf_2280552_2280674 - Class II
  Cleavage pHMM score: -6.70
  RODEO score: 0
  Monoisotopic mass: 3049.7 Da
  Molecular weight: 3051.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3069.7 Da N = 1
    3087.7 Da N = 2
allorf_2285440_2285562 - Class II
  Cleavage pHMM score: -2.70
  RODEO score: 0
  Monoisotopic mass: 3176.6 Da
  Molecular weight: 3178.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3196.6 Da N = 1
    3214.6 Da N = 2
    3232.7 Da N = 3
    3250.7 Da N = 4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
NtrC | Nitrogen regulatory protein C
VqsM | Regulator of quorum-sensing signalling systems
ZuR variant 1 | Zinc-responsive repressor

NZ_CP077072.1 - Region 8 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,536,572 - 2,559,448 nt. (total: 22,877 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase reductase
KR767_RS11190: alkyl hydroperoxide reductase/ Thiol specific

smcogs
  SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

KR767_RS11225: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

Hydrolases: hydrolase
KR767_RS11240: alpha/beta hydrolase domain-containing protein

smcogs
  SMCOG1066: alpha/beta hydrolase domain-containing protein

Lyases: cyclase
KR767_RS11210: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002703.2 |  | 0.48 | ribosomal | archalan α | Halorussus salinus
BGC0000554.4 |  | 0.48 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000584.5 |  | 0.47 | ribosomal | colicin V | Escherichia coli
BGC0000504.5 |  | 0.46 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0002704.2 |  | 0.46 | ribosomal | archalan β | Halorussus salinus
BGC0001579.4 |  | 0.46 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0000500.5 |  | 0.46 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001387.5 |  | 0.45 | other (other) | nucleocidin | Streptomyces calvus
BGC0000503.5 |  | 0.45 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0002346.3 |  | 0.43 | ribosomal | kyamicin | Saccharopolyspora sp.

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002703.2 |  | 0.48 | ribosomal | archalan α | Halorussus salinus
BGC0000554.4 |  | 0.48 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000584.5 |  | 0.47 | ribosomal | colicin V | Escherichia coli
BGC0000504.5 |  | 0.46 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0002704.2 |  | 0.46 | ribosomal | archalan β | Halorussus salinus
BGC0001579.4 |  | 0.46 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0000500.5 |  | 0.46 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001387.5 |  | 0.45 | other (other) | nucleocidin | Streptomyces calvus
BGC0000503.5 |  | 0.45 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0002346.3 |  | 0.43 | ribosomal | kyamicin | Saccharopolyspora sp.

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for KR767_RS11210

allorf_2541699_2541854
Leader:
MRQKGGVRVRCYRSHPGRRGGRFTGRAQGA
Core:
L L H K P P C R S A P R A R P I R S G G L
Core with dehydrations:
L L H K P P Cys R Dha A P R A R P I R Dha G G L

#### antiSMASH-DB 4.0 matches for allorf_2541699_2541854

100.0%
NZ_CP077072.1:
Lanthipeptides: allorf_2541699_2541854_lanthipeptide
1
L L H K P P C R S A P R A R P I R S G G L
21
L L H K P P C R S A P R A R P I R S G G L
1
L L H K P P C R S A P R A R P I R S G G L
21
38.5%
NZ_CP077072.1:
Lanthipeptides: allorf_4767256_4767366_lanthipeptide
6
P C R S A P R A R P I
16
P C R S A P R A R P+
12
P C R S A P R A R P V
22
24.1%
NZ_JAGIYX010000033.1:
Lanthipeptides: allorf_81159_81302_lanthipeptide
8
R S A P R A R P I R S G G
20
R+ R A R +R+G G
6
R T G R R A R C L R A G G
18
allorf_2549811_2549951
Leader:
MPTGITAPRRDVSRRSHLHENGKRSMSSAGG
Core:
C N T P Y A P P R H A E P H D
Core with dehydrations:
Cys N Dhb P Y A P P R H A E P H D

#### antiSMASH-DB 4.0 matches for allorf_2549811_2549951

100.0%
NZ_CP077072.1:
Lanthipeptides: allorf_2549811_2549951_lanthipeptide
1
C N T P Y A P P R H A E P H D
15
C N T P Y A P P R H A E P H D
1
C N T P Y A P P R H A E P H D
15
43.8%
NC_009621.1 and 6 others:
NC_017327.1 Lanthipeptides: allorf_0124171_0124311_lanthipeptide NZ_CP021217.1 Lanthipeptides: allorf_1159796_1159936_lanthipeptide NZ_CP088111.1 Lanthipeptides: allorf_0786224_0786295_lanthipeptide NZ_NBUK01000063.1 Lanthipeptides: allorf_7325_7396_lanthipeptide NZ_VISX01000063.1 Lanthipeptides: allorf_1360_1431_lanthipeptide NZ_VITA01000039.1 Lanthipeptides: allorf_07280_07351_lanthipeptide
Lanthipeptides: allorf_1019980_1020051_lanthipeptide
6
A P P R H A E P H D
15
A P R A E P D
3
A P A R S A E P A D
12
26.9%
NZ_CP079114.1 and 2 others:
NZ_CP079114.1 Lanthipeptides: allorf_2712645_2712809_lanthipeptide NZ_CP079114.1 Lanthipeptides: allorf_2712645_2712809_lanthipeptide
Lanthipeptides: allorf_2712645_2712809_lanthipeptide
2
N T P Y A P P R H A E P
13
N T A P P R P
3
N T G A A P P R F V R P
14
with 1 more sequence matches
25.9%
NZ_CP076103.1:
Lanthipeptides: allorf_4159822_4159995_lanthipeptide
6
A P P R H A E P
13
A P P R H A P
8
A P P R H A N P
15
allorf_2555924_2556031
Leader:
MPRIRQLRLIAG
Core:
T R L T Q D K N R C A A P Y A Y K R D V R R F
Core with dehydrations:
Dhb R L Dhb Q D K N R Cys A A P Y A Y K R D V R R F

#### antiSMASH-DB 4.0 matches for allorf_2555924_2556031

100.0%
NZ_CP077072.1:
Lanthipeptides: allorf_2555924_2556031_lanthipeptide
1
T R L T Q D K N R C A A P Y A Y K R D V R R F
23
T R L T Q D K N R C A A P Y A Y K R D V R R F
1
T R L T Q D K N R C A A P Y A Y K R D V R R F
23
20.8%
NZ_LT630004.1:
Lanthipeptides: allorf_2780737_2780889_lanthipeptide
4
T Q D K N R C A A P Y
14
+ D+N C A P+
11
S S D R N L C D A P W
21
allorf_2556044_2556175
Leader:
MTSLSACRQRRCVGG
Core:
V P C S W S R A G E G S R R H I R V R R T Q A V G C T G
Core with dehydrations:
V P Cys Dha W Dha R A G E G Dha R R H I R V R R Dhb Q A V G Cys Dhb G

#### antiSMASH-DB 4.0 matches for allorf_2556044_2556175

100.0%
NZ_CP077072.1:
Lanthipeptides: allorf_2556044_2556175_lanthipeptide
1
V P C S W S R A G E G S R R H I R V R R T Q A V G C T G
28
V P C S W S R A G E G S R R H I R V R R T Q A V G C T G
1
V P C S W S R A G E G S R R H I R V R R T Q A V G C T G
28
25.0%
NZ_JAJNOJ010000002.1:
Lanthipeptides: allorf_7584253_7584438_lanthipeptide
1
V P C S W S R A G E
10
V P C R A G E
10
V P C R P P R A G E
19
18.6%
NZ_CP067396.1 and 1 other:
NZ_CP110813.1 Lanthipeptides: allorf_0964079_0964300_lanthipeptide
Lanthipeptides: allorf_0994793_0995014_lanthipeptide
11
G S R R H I R V R R T Q A V G C
26
G+R R R R+ A G C
3
G N R R S D R K R K V G A A G C
18
with 4 more sequence matches
17.5%
NZ_CP010407.1 and 2 others:
NZ_CP010407.1 Lanthipeptides: allorf_8470670_8470873_lanthipeptide NZ_CP010407.1 Lanthipeptides: allorf_8470670_8470873_lanthipeptide
Lanthipeptides: allorf_8470670_8470873_lanthipeptide
1
V P C S W S R A G E G S
12
V P C+ R G G S
9
V P C T P D R H G P G S
20
17.5%
NZ_CP038504.1:
Lanthipeptides: allorf_0573691_0573876_lanthipeptide
3
C S W S R A G E G S R R H I R V R R T Q A V
24
C W R +R ++ V R+Q +
14
C I W P R L L I C T R A N L P V L R S Q T M
35
16.7%
NZ_CABWKH010000001.1 and 1 other:
NZ_CP010411.1 Lanthipeptides: allorf_1259634_1259786_lanthipeptide
Lanthipeptides: allorf_022146_022298_lanthipeptide
2
P C S W S R A G
9
P C W R A G
3
P C R W H R A G
10
16.7%
NZ_CP097263.1:
Lanthipeptides: M3Q35_RS17960_lanthipeptide
4
S W S R A G E G S R R H I R V R R T Q A V G C
26
S W+R G E + ++ A+G C
13
S W T R R G E A A L N N V-----L A I G C
30
allorf_2556081_2556245
Leader:
MAGFRAHGVALA
Core:
K G A E G T Y V S G E R K L S V V P G R A G G R C V L R G N A C V E S P C N R A C A
Core with dehydrations:
K G A E G Dhb Y V Dha G E R K L Dha V V P G R A G G R Cys V L R G N A Cys V E Dha P Cys N R A Cys A

#### antiSMASH-DB 4.0 matches for allorf_2556081_2556245

100.0%
NZ_CP077072.1:
Lanthipeptides: allorf_2556081_2556245_lanthipeptide
1
K G A E G T Y V S G E R K L S V V P G R A G G R C V L R G N A C V E S P C N R A C A
42
K G A E G T Y V S G E R K L S V V P G R A G G R C V L R G N A C V E S P C N R A C A
1
K G A E G T Y V S G E R K L S V V P G R A G G R C V L R G N A C V E S P C N R A C A
42
23.8%
NZ_CP016767.1 and 3 others:
NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide
Lanthipeptides: BCV50_RS13415_lanthipeptide
14
L S V V P G R A G G R C V L R G N A C V E S P C N R A C
41
L S V+ G + N C + C R A C
5
L S V I T G Y------I S S N T C P T T A C T R A C
26
21.4%
NZ_CP120210.1:
Lanthipeptides: allorf_4400817_4401044_lanthipeptide
12
R K L S V V P G R A G G R C V L R G N A C V E S
35
R +V P G R +L R + V S
3
R H R A V A P P S D A G R V L L R S D V V V S S
26
with 9 more sequence matches
19.0%
NZ_BMMP01000005.1 and 3 others:
NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptide NZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide NZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide
Lanthipeptides: IEY56_RS28370_lanthipeptide
8
V S G E R K L S V V P G R A G G R C V L
27
+ L S V G G G C L
2
T T N T F S L S D V L G N T G G W C T L
21
16.7%
NZ_BLIS01000009.1 and 5 others:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide
Lanthipeptides: GVO03_RS04825_lanthipeptide
27
L R G N A C V E S P C N R A C
41
+ N C S C R A C
25
V S A N T C P T S A C T R A C
39
16.7%
NZ_CABWKH010000001.1:
Lanthipeptides: allorf_004703_004852_lanthipeptide
8
V S G E R K L S V V P G R A G
22
V G+R+ +V G R A
24
V F G D R R Y F L V L G R A A
38
16.7%
NZ_CP051884.1 and 3 others:
NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide
Lanthipeptides: HGK68_RS15130_lanthipeptide
27
L R G N A C V E S P C N R A C
41
+ N C S C R A C
14
I S N N T C P S S A C T R A C
28
14.3%
NZ_CP061868.1 and 1 other:
NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide
Lanthipeptides: IE339_RS06335_lanthipeptide
27
L R G N A C V E S P C N R A C
41
+ N C + C R A C
14
I S T N T C P T T S C T R A C
28
14.3%
NZ_JALAPU010000003.1 and 9 others:
NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide
Lanthipeptides: MOD17_RS07925_lanthipeptide
27
L R G N A C V E S P C N R A C
41
+ N C + C R A C
12
I S S N T C P T T A C T R A C
26
14.3%
NZ_LR134317.1 and 1 other:
NZ_LR134317.1 Lanthipeptides: EL136_RS01690_lanthipeptide
Lanthipeptides: EL136_RS01690_lanthipeptide
27
L R G N A C V E S P C N R A C
41
+ N C + C R A C
19
I S A N T C P T T S C T R A C
33
14.3%
NZ_MIFN01000022.1 and 1 other:
NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15355_lanthipeptide
Lanthipeptides: BHL26_RS15355_lanthipeptide
27
L R G N A C V E S P C N R A C
41
+ N C + C R A C
19
I S S N T C P S T A C T R A C
33
14.3%
NZ_PCGR01000003.1 and 1 other:
NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide
Lanthipeptides: CQS04_RS09625_lanthipeptide
27
L R G N A C V E S P C N R A C
41
+ N+C + C R A C
14
I S A N S C P T T A C T R A C
28

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.92 out of 29.65
Confidence: medium
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.01 out of 26.85
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.80 out of 20.47
Confidence: medium
Additional weak hits (8):
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.92 out of 26.33
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.61 out of 29.38
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.70 out of 39.62
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.03 out of 26.12
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.50 out of 20.01
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.94 out of 27.55
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.16 out of 30.22
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.17 out of 28.19
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

allorf_2541699_2541854 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 2245.3 Da
  Molecular weight: 2246.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2264.7 Da N = 1
allorf_2549811_2549951 - Class II
  Cleavage pHMM score: -2.20
  RODEO score: 0
  Monoisotopic mass: 1685.7 Da
  Molecular weight: 1686.8 Da
  Number of bridges: 1
allorf_2555924_2556031 - Class II
  Cleavage pHMM score: -6.30
  RODEO score: 0
  Monoisotopic mass: 2791.5 Da
  Molecular weight: 2793.2 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2811.2 Da N = 1
allorf_2556044_2556175 - Class II
  Cleavage pHMM score: -5.20
  RODEO score: 0
  Monoisotopic mass: 2991.6 Da
  Molecular weight: 2993.4 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3011.4 Da N = 1
    3029.4 Da N = 2
    3047.4 Da N = 3
allorf_2556081_2556245 - Class II
  Cleavage pHMM score: -5.50
  RODEO score: 0
  Monoisotopic mass: 4205.1 Da
  Molecular weight: 4207.8 Da
  Number of bridges: 4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 1 | Repressor of DNA damage response
RutR | Regulator of the pyrimidine and purine metabolism
VqsM | Regulator of quorum-sensing signalling systems

NZ_CP077072.1 - Region 9 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,825,728 - 2,897,422 nt. (total: 71,695 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: acyltransferase
KR767_RS12475: polyketide synthase associated protein papA3

smcogs
  SMCOG1209: polyketide synthase associated protein papA3

Hydrolases: peptidase
KR767_RS12555: gamma-glutamyltranspeptidase

smcogs
  SMCOG1274: gamma-glutamyltranspeptidase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001758.4 |  | 0.77 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001833.4 |  | 0.77 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.76 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001132.4 |  | 0.75 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.75 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.75 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.75 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001641.4 |  | 0.73 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001261.3 |  | 0.69 | NRPS | AM-toxin | Alternaria alternata

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001758.4 |  | 0.77 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001833.4 |  | 0.77 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.76 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001132.4 |  | 0.75 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.75 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.75 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.75 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001641.4 |  | 0.73 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001261.3 |  | 0.69 | NRPS | AM-toxin | Alternaria alternata

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46
Confidence: strong
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.60 out of 29.72
Confidence: medium
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.28 out of 20.01
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.60 out of 19.26
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.19 out of 23.79
Confidence: medium
Additional weak hits (5):
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 19.13 out of 30.97
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.21 out of 20.01
Confidence: weak
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.22 out of 20.97
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.59 out of 18.57
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.02 out of 32.74
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 9, location 2825727 - 2897422:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Leu - Ser - X - Ile - Leu - X - Leu - Gln - Ile)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KR767_RS12475: Leu - Ser - X - Ile - Leu - X - Leu - Gln - Ile
Search NORINE for peptide: strict or relaxed
AMP-binding (703..1095): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHAFDASAWEPFLLVGGDTNNYGPTETTVVATS
  Nearest Stachelhaus code(s):
    Leu DAWFLGNVVK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1757..2160): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFMCSGEHNLYGPTEAAVDVTA
  Nearest Stachelhaus code(s):
    Ser DVWHMSLVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2842..3239): X
nrpys: Gln, Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWSSFDATITSTKIVIGGEINEYGPTETVVGCAI
  Nearest Stachelhaus code(s):
    Gln or Asn DATKVGEVGK (91% 8Å match)
    Asn DATKVGEVGK (88% 8Å match)
    OH-Asn or Asn DATKVGEVGK (79% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (3922..4318): Ile
nrpys: Ile

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    ile (Ile)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNNAFDASTMEGFAMSGGELNCYGPTETTTYATT
  Nearest Stachelhaus code(s):
    Ile DAMFMGCTFK (88% 8Å match)
  Stachelhaus code match:
    90% (moderate)

AMP-binding (5422..5811): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHAFDASAWEPFLLVGGDTNNYGPTETTVVATS
  Nearest Stachelhaus code(s):
    Leu DAWFLGNVVK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (6494..6891): X
nrpys: Asn, OH-Asn, Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDATVTSVKIVIGGEVNEYGPTETVVGCAI
  Nearest Stachelhaus code(s):
    Asn DATKVGEVGK (88% 8Å match)
    OH-Asn or Asn DATKVGEVGK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (7575..7964): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHAFDASAWEPFLLVGGDTNNYGPTETTVVATS
  Nearest Stachelhaus code(s):
    Leu DAWFLGNVVK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (8626..9027): Gln
nrpys: Gln

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    gln (Gln)

Stachelhaus prediction details:
  Stachelhaus sequence:
    HWQTFDASVWETQLFCGGEVNLYGPTETTIDATS
  Nearest Stachelhaus code(s):
    Gln DAWQFGLIDK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (9709..10106): Ile
nrpys: Ile

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    ile (Ile)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNNAFDASTVEGFVMCGGEVHCYGPTEATTYATT
  Nearest Stachelhaus code(s):
    Ile DALFMGCTYK (88% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArgR | Regulator of arginine biosynthesis genes
CRP | Cyclic AMP receptor protein
IolR | Regulator of the inositol catabolism
NtrC | Nitrogen regulatory protein C
RpoN | Regulator of nitrogen assimilation and virulence

NZ_CP077072.1 - Region 10 - NRPS,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,682,473 - 3,735,023 nt. (total: 52,551 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
KR767_RS15990: nucleotide sugar dehydrogenase

smcogs
  SMCOG1152: nucleotide sugar dehydrogenase

Transferases: glycosyltransferase
KR767_RS15895: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

KR767_RS15905: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

KR767_RS15910: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

KR767_RS15975: sugar transferase

smcogs
  SMCOG1146: sugar transferase

Hydrolases: deacetylase
KR767_RS15900: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Lyases: dehydratase
KR767_RS15985: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase
KR767_RS15935: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

KR767_RS15940: Beta-ketoacyl synthase

smcogs
  SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002135.2 |  |  | 0.77 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  |  | 0.75 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  |  | 0.74 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000342.4 |  |  | 0.72 | NRPS | enniatin | Fusarium equiseti
BGC0001128.4 |  |  | 0.71 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002286.3 |  |  | 0.69 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0000307.4 |  |  | 0.67 | NRPS | AbT1 | Aureobasidium pullulans
BGC0002164.2 |  |  | 0.66 | NRPS | peramine | Epichloe festucae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.70 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.70 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000342.4 |  | 0.69 | NRPS | enniatin | Fusarium equiseti
BGC0001128.4 |  | 0.68 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  | 0.68 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002286.3 |  | 0.68 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.67 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0000307.4 |  | 0.67 | NRPS | AbT1 | Aureobasidium pullulans
BGC0002164.2 |  | 0.66 | NRPS | peramine | Epichloe festucae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.77 out of 29.51
Confidence: medium
Additional weak hits (11):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.52 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.05 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.76 out of 29.38
Confidence: weak
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.25 out of 20.97
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.17 out of 18.57
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.22 out of 21.55
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.55 out of 28.19
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 35.63
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.43 out of 35.63
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.44 out of 28.19
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.45 out of 35.63
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 10, location 3682472 - 3735023:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Val - mal) + (X - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KR767_RS15935: X - X
AMP-binding (486..882): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FAMTFDIAFMELQAISGGEWNGYGPTETTVYSTY
  Nearest Stachelhaus code(s):
    Gly DILQIGMVWK (82% 8Å match)
    Ala DILQITLVYK (71% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (1544..1828): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    RTTL--------HTVWLDE--------ATPAIAF
  Nearest Stachelhaus code(s):
  Stachelhaus code match:
    0% (weak)

KR767_RS15940: Val - mal
Search NORINE for peptide: strict or relaxed
AMP-binding (18..397): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHSAFDASTLEAWLLTGGEVNGYGPTECTTFATT
  Nearest Stachelhaus code(s):
    Val DALWLGGTFK (82% 8Å match)
    bOH-Val DALWLGGTFK (76% 8Å match)
  Stachelhaus code match:
    100% (strong)

PKS_AT (1113..1401): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 87.5%
  inactive: 83.3%
  Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 158.1
  Methylmalonyl-CoA: 77.5
  inactive: 73.6
  Methoxymalonyl-CoA: 71.2
  Propionyl-CoA: 54.1
  Isobutyryl-CoA: 35.4
  Ethylmalonyl-CoA: 31.9
  Benzoyl-CoA: 30.0
  Acetyl-CoA: 29.8
  fatty_acid: 21.9
  CHC-CoA: 21.9
  trans-1,2-CPDA: 18.9
  3-Methylbutyryl-CoA: 6.8
  2-Methylbutyryl-CoA: -2.0

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
DosR | Hypoxia stress response regulator

NZ_CP077072.1 - Region 11 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,880,425 - 3,913,098 nt. (total: 32,674 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: sulfotransferase
KR767_RS16595: glutathione S-transferase

smcogs
  SMCOG1193: glutathione S-transferase

Lyases: decarboxylase
KR767_RS16565: diaminopimelate decarboxylase

smcogs
  SMCOG1264: diaminopimelate decarboxylase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000946.5 |  | 0.79 | other (other) | vibrioferrin | Vibrio parahaemolyticus
BGC0001408.5 |  | 0.73 | other (other) | xanthoferrin | Xanthomonas oryzae pv. oryzae KACC 10331
BGC0002527.2 |  | 0.73 | other (other) | vibrioferrin | Azotobacter vinelandii CA
BGC0000947.5 |  | 0.63 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0000943.5 |  | 0.49 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002692.2 |  | 0.48 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0002683.2 |  | 0.45 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0002694.2 |  | 0.41 | other (other) | roseobactin | Phaeobacter inhibens 2.10
BGC0002466.3 |  | 0.40 | NRPS | peucechelin | Streptomyces peucetius subsp. caesius ATCC 27952
BGC0002755.2 |  | 0.34 | NRPS | clovibactin | Eleftheria terrae P9846

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000946.5 |  | 0.79 | other (other) | vibrioferrin | Vibrio parahaemolyticus
BGC0001408.5 |  | 0.73 | other (other) | xanthoferrin | Xanthomonas oryzae pv. oryzae KACC 10331
BGC0002527.2 |  | 0.73 | other (other) | vibrioferrin | Azotobacter vinelandii CA
BGC0000947.5 |  | 0.63 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0000943.5 |  | 0.49 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002692.2 |  | 0.48 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0002683.2 |  | 0.45 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0002694.2 |  | 0.41 | other (other) | roseobactin | Phaeobacter inhibens 2.10
BGC0002466.3 |  | 0.40 | NRPS | peucechelin | Streptomyces peucetius subsp. caesius ATCC 27952
BGC0002755.2 |  | 0.34 | NRPS | clovibactin | Eleftheria terrae P9846

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.28 out of 29.38
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.65 out of 28.19
Confidence: medium
Additional weak hits (12):
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.47 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.53 out of 29.38
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 20.30 out of 31.73
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.63 out of 32.74
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.06 out of 26.06
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.09 out of 30.98
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.74 out of 28.14
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.41 out of 28.19
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.65 out of 28.19
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.40 out of 32.93
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 24.70 out of 30.12
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 21.63 out of 35.63
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
FuR variant 1 | Ferric Uptake Regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_CP077072.1 - Region 12 - NRP-metallophore,NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,117,764 - 4,182,637 nt. (total: 64,874 nt) Show pHMM detection rules used
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxygenase reductase
KR767_RS17575: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

KR767_RS17625: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

Transferases: PPTase acyltransferase
KR767_RS17615: acyltransferase 3

smcogs
  SMCOG1088: acyltransferase 3

KR767_RS17620: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1060: 4'-phosphopantetheinyl transferase

Hydrolases: esterase hydrolase
KR767_RS17485: HAD-superfamily hydrolase, subfamily IA, variant

smcogs
  SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

KR767_RS17595: thioesterase

smcogs
  SMCOG1004: thioesterase

Isomerases: isomerase
KR767_RS17605: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase
KR767_RS17540: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

KR767_RS17590: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Translocases: permease
KR767_RS17490: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRP-metallophore | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002286.3 |  |  | 0.61 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  |  | 0.61 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  |  | 0.60 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  |  | 0.60 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001758.4 |  |  | 0.60 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001825.4 |  |  | 0.60 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001641.4 |  |  | 0.60 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4 |  |  | 0.59 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0002075.3 |  |  | 0.59 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000357.5 |  |  | 0.59 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002286.3 |  | 0.64 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  | 0.64 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.64 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.64 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001758.4 |  | 0.64 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001825.4 |  | 0.63 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001641.4 |  | 0.63 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4 |  | 0.63 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0002075.3 |  | 0.63 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000357.5 |  | 0.63 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.16 out of 20.97
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.38 out of 19.26
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.54 out of 20.97
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.94 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.18 out of 29.38
Confidence: medium
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.14 out of 29.72
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46
Confidence: medium
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.03 out of 29.72
Confidence: medium
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.56 out of 33.14
Confidence: medium
Additional weak hits (21):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.56 out of 29.38
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.27 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.08 out of 29.25
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 19.33 out of 30.97
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.78 out of 29.38
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.91 out of 31.73
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.57 out of 26.85
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.20 out of 21.55
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.45 out of 30.25
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 24.26 out of 30.22
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.94 out of 29.65
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.17 out of 28.19
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.46 out of 32.93
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.52 out of 32.93
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.50 out of 35.63
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.73 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.35 out of 28.14
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.80 out of 29.25
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.45 out of 28.19
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.85 out of 28.19
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.32 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 12, location 4117763 - 4182637:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Ser - Cys) + (Me-Cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KR767_RS17540: Ser - Cys
Search NORINE for peptide: strict or relaxed
AMP-binding (563..940): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TDLSFDLSVYDANCLLGGDIALGGTTETAIHSTF
  Nearest Stachelhaus code(s):
    Ser DLYNLGLIHK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1597..1980): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TDVSFDLSVFDANSLISGDIALGGATEASVWSNY
  Nearest Stachelhaus code(s):
    Cys DLFNLSLVWK (79% 8Å match)
  Stachelhaus code match:
    100% (strong)

KR767_RS17545: Cys
Search NORINE for peptide: strict or relaxed
AMP-binding (529..922): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TDIAFDLSVYDGNSLLSGDIGLGGATEASIWSNY
  Nearest Stachelhaus code(s):
    Cys DLYNLSLIWK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

KR767_RS17590: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (36..435): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    NESLFPLACPGGALQAGGAQQVYGMAEGLLCYTR
  Nearest Stachelhaus code(s):
    diOH-Bz PLPAQGVLCK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CcpA | Catabolite control protein A
FuR variant 1 | Ferric Uptake Regulator
NtrC | Nitrogen regulatory protein C
RpoN | Regulator of nitrogen assimilation and virulence
ZuR variant 2 | Zinc-responsive repressor

NZ_CP077072.1 - Region 13 - T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,502,945 - 4,548,698 nt. (total: 45,754 nt) Show pHMM detection rules used
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: synthase
KR767_RS19085: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Translocases: transport
KR767_RS19035: MMPL domain-containing transport protein

smcogs
  SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000056.3 |  | 0.70 | PKS | esperamicin | Actinomadura verrucosospora
BGC0001164.3 |  | 0.57 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001160.5 |  | 0.57 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001284.4 |  | 0.57 | PKS | alternariol | Parastagonospora nodorum SN15
BGC0001276.3 |  | 0.56 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0002191.2 |  | 0.56 | PKS | prolipyrone B, gibepyrone D | Fusarium graminearum PH-1
BGC0001273.3 |  | 0.56 | PKS | asperlactone | Aspergillus ochraceus
BGC0002154.2 |  | 0.56 | PKS | 1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene | Pyricularia oryzae 70-15
BGC0002175.3 |  | 0.56 | PKS | YWA1 | Aspergillus oryzae RIB40
BGC0001257.3 |  | 0.56 | PKS | 1,3,6,8-tetrahydroxynaphthalene | Nodulisporium sp. ATCC74245

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000056.3 |  | 0.70 | PKS | esperamicin | Actinomadura verrucosospora
BGC0001164.3 |  | 0.57 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001160.5 |  | 0.57 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001284.4 |  | 0.57 | PKS | alternariol | Parastagonospora nodorum SN15
BGC0001276.3 |  | 0.56 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0002191.2 |  | 0.56 | PKS | prolipyrone B, gibepyrone D | Fusarium graminearum PH-1
BGC0001273.3 |  | 0.56 | PKS | asperlactone | Aspergillus ochraceus
BGC0002154.2 |  | 0.56 | PKS | 1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene | Pyricularia oryzae 70-15
BGC0002175.3 |  | 0.56 | PKS | YWA1 | Aspergillus oryzae RIB40
BGC0001257.3 |  | 0.56 | PKS | 1,3,6,8-tetrahydroxynaphthalene | Nodulisporium sp. ATCC74245

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Location:
Identifier
Identity
Coverage
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26
Confidence: medium
Additional weak hits (8):
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.51 out of 21.84
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.68 out of 28.14
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.91 out of 27.78
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.96 out of 26.06
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 20.87 out of 31.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.95 out of 31.73
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 23.66 out of 30.22
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.79 out of 22.40
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS substrates
TFBS Finder
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KR767_RS19085: mal
PKS_AT (610..837): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 75.0%
  inactive: 62.5%
  Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 77.8
  Methoxymalonyl-CoA: 65.9
  Methylmalonyl-CoA: 57.4
  Ethylmalonyl-CoA: 31.9
  Isobutyryl-CoA: 30.3
  trans-1,2-CPDA: 24.2
  inactive: 22.8
  Benzoyl-CoA: 17.8
  CHC-CoA: 17.6
  Acetyl-CoA: 14.9
  2-Methylbutyryl-CoA: 14.5
  fatty_acid: 13.0
  Propionyl-CoA: 12.7
  3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein

NZ_CP077072.1 - Region 14 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,753,378 - 4,776,317 nt. (total: 22,940 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: glycosyltransferase transferase
KR767_RS20360: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

KR767_RS20385: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Lyases: cyclase lyase
KR767_RS20370: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

KR767_RS20410: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000528.5 |  | 0.47 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001579.4 |  | 0.46 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0000503.5 |  | 0.43 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0002698.2 |  | 0.43 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0001210.5 |  | 0.43 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001364.3 |  | 0.42 | ribosomal | cinnamycin B | Actinomadura atramentaria DSM 43919
BGC0002346.3 |  | 0.41 | ribosomal | kyamicin | Saccharopolyspora sp.
BGC0000517.4 |  | 0.41 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001594.3 |  | 0.41 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0001229.4 |  | 0.41 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000528.5 |  | 0.47 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001579.4 |  | 0.46 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0000503.5 |  | 0.43 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0002698.2 |  | 0.43 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0001210.5 |  | 0.43 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001364.3 |  | 0.42 | ribosomal | cinnamycin B | Actinomadura atramentaria DSM 43919
BGC0002346.3 |  | 0.41 | ribosomal | kyamicin | Saccharopolyspora sp.
BGC0000517.4 |  | 0.41 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001594.3 |  | 0.41 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0001229.4 |  | 0.41 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for KR767_RS20370

KR767_RS20375
Leader:
MSNEMGFSSKSVSRAAEWRKQAGNGNPAGDLFANAFAEADIVGG
Core:
T E I A V T D C A M C T G S I K T T K I T Q C A
Core with dehydrations:
Dhb E I A V Dhb D Cys A M Cys Dhb G Dha I K Dhb Dhb K I Dhb Q Cys A

#### antiSMASH-DB 4.0 matches for KR767_RS20375

100.0%
NZ_CP077072.1:
Lanthipeptides: KR767_RS20375_lanthipeptide
1
T E I A V T D C A M C T G S I K T T K I T Q C A
24
T E I A V T D C A M C T G S I K T T K I T Q C A
1
T E I A V T D C A M C T G S I K T T K I T Q C A
24
66.7%
NZ_FNBR01000006.1 and 1 other:
NZ_FUYT01000011.1 Lanthipeptides: B5X73_RS13320_lanthipeptide
Lanthipeptides: BLT40_RS18630_lanthipeptide
1
T E I A V T D C A M C T G S I K T T K I T Q C A
24
T++ V T D C A M C T G S I K T C A
1
T D M L V T D C A M C T G S I K N T I H I Y C A
24
62.5%
NZ_CP095740.1:
Lanthipeptides: L2Y94_RS08185_lanthipeptide
1
T E I A V T D C A M C T G S I K T T K I T Q C A
24
T E+ V T C A M C T G S I+ T C A
1
T E M L V T G C A M C T G S I E H T I R I A C A
24
with 14 more sequence matches
Only the first 10 are displayed here.
57.7%
NZ_CP077072.1:
Lanthipeptides: KR767_RS20380_lanthipeptide
1
T E I A V T D C A M C T G S I K T-T K I T Q C A
24
T+I V T D C M C T G S I T+ Q C
1
T D I V V T D C V M C T G S I D A R T R H I Q C G
25
46.2%
NZ_CP095740.1:
Lanthipeptides: L2Y94_RS08180_lanthipeptide
1
T E I A V T D C A M C T G S I K-T T K I T Q C A
24
T+I V T+C +C T G S+ T+ Q C
1
T D I I V T N C V L C T G S V D A N T R H V Q C G
25
22.6%
NZ_CP048887.1:
Lanthipeptides: BMG_RS29400_lanthipeptide
1
T E I A V T D C A M C T G
13
T +A V T A+C G
8
T P V A V T S S A V C I G
20
19.5%
NZ_CP010407.1 and 4 others:
NZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptide NZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptide NZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptide NZ_JACHJY010000017.1 Lanthipeptides: GGE06_RS39715_lanthipeptide
Lanthipeptides: SVTN_RS37515_lanthipeptide
1
T E I A V T D C A M C T G S I K T
17
T E +T C+ C T G S+ +
22
T E A L L T G C S S C T G S L H S
38
19.5%
NZ_CP029194.1 and 1 other:
NZ_CP059991.1 Lanthipeptides: H4W23_RS35675_lanthipeptide
Lanthipeptides: DEJ46_RS04155_lanthipeptide
1
T E I A V T D C A M C T G S I K T
17
T E +T C+ C T G S +
22
T E A L L T G C S S C T G S W H S
38
19.5%
NZ_JH941044.1:
Lanthipeptides: Y19_RS0126875_lanthipeptide
1
T E I A V T D C A M C T G S I K T
17
T E T C+ C T G S +
22
T E A L F T G C S S C T G S W H S
38
17.8%
NZ_JACHYJ010000001.1:
Lanthipeptides: FHW73_RS02140_lanthipeptide
6
T D C A M C T G S I
15
T+C A C T G S I
31
T N C A D C T G S I
40
15.4%
NZ_FOSG01000018.1 and 1 other:
NZ_PDKQ02000037.1 Lanthipeptides: BFM75_RS14295_lanthipeptide
Lanthipeptides: BM237_RS22045_lanthipeptide
1
T E I A V T D C A M C T G S I K T
17
T+ T C+ C T G S+ T
33
T D A L F T A C S S C T G S L T T
49
14.8%
NZ_CP076103.1:
Lanthipeptides: KME82_RS02870_lanthipeptide
4
A V T D C A M C T G S I K
16
A+T C++C T G S I+
37
A I T G C S L C T G S I R
49
14.0%
NZ_QSFS01000023.1:
Lanthipeptides: DW924_RS15110_lanthipeptide
6
T D C A M C T G S I K T T K
19
+ C A C T G S K ++
34
S Q C A P C T G S S K G S Q
47
KR767_RS20380
Leader:
MIVESMRASQPAGRAAFWRSNACADSPAGALFANEFAEADIVGG
Core:
T D I V V T D C V M C T G S I D A R T R H I Q C G A
Core with dehydrations:
Dhb D I V V Dhb D Cys V M Cys Dhb G Dha I D A R Dhb R H I Q Cys G A

#### antiSMASH-DB 4.0 matches for KR767_RS20380

100.0%
NZ_CP077072.1:
Lanthipeptides: KR767_RS20380_lanthipeptide
1
T D I V V T D C V M C T G S I D A R T R H I Q C G A
26
T D I V V T D C V M C T G S I D A R T R H I Q C G A
1
T D I V V T D C V M C T G S I D A R T R H I Q C G A
26
76.9%
NZ_CP095740.1:
Lanthipeptides: L2Y94_RS08180_lanthipeptide
1
T D I V V T D C V M C T G S I D A R T R H I Q C G A
26
T D I+V T+C V+C T G S+D A T R H+Q C G A
1
T D I I V T N C V L C T G S V D A N T R H V Q C G A
26
61.5%
NZ_FNBR01000006.1 and 1 other:
NZ_FUYT01000011.1 Lanthipeptides: B5X73_RS13320_lanthipeptide
Lanthipeptides: BLT40_RS18630_lanthipeptide
1
T D I V V T D C V M C T G S I D A R T R H I Q C G
25
T D++V T D C M C T G S I T H I C
1
T D M L V T D C A M C T G S I K-N T I H I Y C A
24
with 19 more sequence matches
Only the first 10 are displayed here.
57.7%
NZ_CP077072.1:
Lanthipeptides: KR767_RS20375_lanthipeptide
1
T D I V V T D C V M C T G S I D A R T R H I Q C G
25
T+I V T D C M C T G S I T+ Q C
1
T E I A V T D C A M C T G S I K T-T K I T Q C A
24
42.3%
NZ_CP095740.1:
Lanthipeptides: L2Y94_RS08185_lanthipeptide
1
T D I V V T D C V M C T G S I D A R T R
20
T+++V T C M C T G S I+ R
1
T E M L V T G C A M C T G S I E H T I R
20
19.2%
NZ_CGZJ01000010.1 and 1 other:
NZ_CRIA01000002.1 Lanthipeptides: AKS83_RS03030_lanthipeptide
Lanthipeptides: AQF97_RS08515_lanthipeptide
12
T G S I D A R T R H I Q C G
25
T G S + + +++C G
4
T G S Y E C T S N N V K C G
17
18.8%
NZ_AP023392.1 and 8 others:
NZ_CP015557.1 Lanthipeptides: A6M16_RS04825_lanthipeptide NZ_CP065430.1 Lanthipeptides: I5V48_RS05970_lanthipeptide NZ_CP100430.1 Lanthipeptides: NLY76_RS04560_lanthipeptide NZ_JAEUXF010000003.1 Lanthipeptides: JNE40_RS02525_lanthipeptide NZ_VMLD01000009.1 Lanthipeptides: HT679_RS04540_lanthipeptide NZ_VMLI01000004.1 Lanthipeptides: HT696_RS02290_lanthipeptide NZ_VMMD01000015.1 Lanthipeptides: HT711_RS05575_lanthipeptide NZ_VMMI01000027.1 Lanthipeptides: HT721_RS06695_lanthipeptide
Lanthipeptides: H7679_RS04975_lanthipeptide
12
T G S I D A R T R H I Q C G
25
T G S + + H++C G
19
T G S F E C T S N H V K C G
32
18.8%
NZ_CGZJ01000010.1 and 15 others:
NZ_CP028436.1 Lanthipeptides: DA395_RS05845_lanthipeptide NZ_CP031248.1 Lanthipeptides: DV130_RS02040_lanthipeptide NZ_CP040803.1 Lanthipeptides: FHI56_RS00865_lanthipeptide NZ_CP090008.1 Lanthipeptides: LV497_RS10155_lanthipeptide NZ_CP113267.1 Lanthipeptides: OTB22_RS04695_lanthipeptide NZ_CRIA01000002.1 Lanthipeptides: AKS83_RS03025_lanthipeptide NZ_FHPK02000016.1 Lanthipeptides: AZ518_RS08970_lanthipeptide NZ_FNJT01000001.1 Lanthipeptides: BLS46_RS03555_lanthipeptide NZ_FZCI01000021.1 Lanthipeptides: CFV25_RS09680_lanthipeptide NZ_JALDWE010000003.1 Lanthipeptides: M1F86_RS04915_lanthipeptide NZ_JUQX01000059.1 Lanthipeptides: ADI74_RS08840_lanthipeptide NZ_LR699783.1 Lanthipeptides: F1569_RS03120_lanthipeptide NZ_NANQ01000004.1 Lanthipeptides: B5K28_RS02515_lanthipeptide NZ_NANU01000009.1 Lanthipeptides: B5K23_RS03060_lanthipeptide NZ_NCUW01000030.1 Lanthipeptides: B7709_RS09425_lanthipeptide
Lanthipeptides: AQF97_RS08510_lanthipeptide
12
T G S I D A R T R H I Q C G
25
T G S + T +++C G
19
T G S F E C T T N N V K C G
32
18.8%
NZ_CP040803.1 and 1 other:
NZ_CP090008.1 Lanthipeptides: LV497_RS10150_lanthipeptide
Lanthipeptides: FHI56_RS00860_lanthipeptide
12
T G S I D A R T R H I Q C G
25
T G S + T +++C G
19
T G S Y E C T T N N V K C G
32
17.1%
NZ_CP010407.1 and 4 others:
NZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptide NZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptide NZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptide NZ_JACHJY010000017.1 Lanthipeptides: GGE06_RS39715_lanthipeptide
Lanthipeptides: SVTN_RS37515_lanthipeptide
1
T D I V V T D C V M C T G S I
15
T+ ++T C C T G S+
22
T E A L L T G C S S C T G S L
36
17.1%
NZ_CP029194.1 and 1 other:
NZ_CP059991.1 Lanthipeptides: H4W23_RS35675_lanthipeptide
Lanthipeptides: DEJ46_RS04155_lanthipeptide
1
T D I V V T D C V M C T G S
14
T+ ++T C C T G S
22
T E A L L T G C S S C T G S
35
17.1%
NZ_JH941044.1:
Lanthipeptides: Y19_RS0126875_lanthipeptide
1
T D I V V T D C V M C T G S
14
T+ + T C C T G S
22
T E A L F T G C S S C T G S
35
16.7%
NZ_CP014326.1:
Lanthipeptides: AXK38_RS11340_lanthipeptide
10
M C T G S I D A R T R H I Q C G
25
+ T S + T H+ C G
21
L F T Y S F E C S T P H V S C G
36

#### MIBiG 4.0 matches for KR767_RS20380

15.4%
BGC0000468.5 (CCM09443.1)and 2 others:
BGC0000469.6 (AFV25481.1) Bottromycin: bottromycin A2 BGC0001157.6 (CBG72694.1) Bottromycin: bottromycin A2
Bottromycin: bottromycin A2
3
I V V T D C
8
+V V D C
3
V V V F D C
8
11.5%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
6
T D C V M C
11
T C++C
17
T I C L V C
22
allorf_4753534_4753761
Leader:
MHPVARKARSYRDCVSLDGYRNDWRQSRCNAIVFA
Core:
G K P R R W V P A C A G T T G A I F E N I S I P K R V R N L V R C V R C L L V R
Core with dehydrations:
G K P R R W V P A Cys A G Dhb Dhb G A I F E N I Dha I P K R V R N L V R Cys V R Cys L L V R

#### antiSMASH-DB 4.0 matches for allorf_4753534_4753761

100.0%
NZ_CP077072.1:
Lanthipeptides: allorf_4753534_4753761_lanthipeptide
1
G K P R R W V P A C A G T T G A I F E N I S I P K R V R N L V R C V R C L L V R
40
G K P R R W V P A C A G T T G A I F E N I S I P K R V R N L V R C V R C L L V R
1
G K P R R W V P A C A G T T G A I F E N I S I P K R V R N L V R C V R C L L V R
40
15.0%
NZ_JAQCXO010000012.1:
Lanthipeptides: PGY55_RS14570_lanthipeptide
10
C A G T T G A I F E N I S I P K
25
A +G+ F E I P+
7
A A R N S G S F F E K R D I P R
22
15.0%
NZ_QGTL01000006.1:
Lanthipeptides: allorf_311998_312129_lanthipeptide
7
V P A C A G T T
14
+P A C A G+T
11
I P A C A G S T
18
with 1 more sequence matches
12.5%
NZ_CP078091.1:
Lassopeptides: KVF90_RS04685_lassopeptide
3
P R R W V P A C A G
12
P R++P A G
13
P S R Y I P G V A G
22
allorf_4755020_4755199
Leader:
MCSVETSAFVGFRSVARARLSASRSARERGG
Core:
A R G D G C G P W R S G L R C P S G K E E P L R G S V F
Core with dehydrations:
A R G D G Cys G P W R Dha G L R Cys P Dha G K E E P L R G Dha V F

#### antiSMASH-DB 4.0 matches for allorf_4755020_4755199

100.0%
NZ_CP077072.1:
Lanthipeptides: allorf_4755020_4755199_lanthipeptide
1
A R G D G C G P W R S G L R C P S G K E E P L R G S V F
28
A R G D G C G P W R S G L R C P S G K E E P L R G S V F
1
A R G D G C G P W R S G L R C P S G K E E P L R G S V F
28
36.7%
NZ_CP103871.1 and 1 other:
NZ_CP103871.1 Lanthipeptides: NYE86_RS08200_lanthipeptide
Lanthipeptides: NYE86_RS08200_lanthipeptide
1
A R G D G C G P W R S G--L R C P S G K E E P
22
+ G D G C G S G C S E+P
6
S T G D G C G S T C S G G A S A C S S F V E D P
29
32.1%
NZ_CP031264.1 and 1 other:
NZ_CP031264.1 Lanthipeptides: C7M71_RS08475_lanthipeptide
Lanthipeptides: C7M71_RS08475_lanthipeptide
4
D G C G P W R S G L R C P S G K E E P L
23
D G C G S G C S ++P+
3
D G C G S S C S G S A C T S F T D D P V
22
with 30 more sequence matches
Only the first 10 are displayed here.
32.1%
NZ_JAMTCT010000035.1 and 1 other:
NZ_JAMTCT010000035.1 Lanthipeptides: APR04_RS28805_lanthipeptide
Lanthipeptides: APR04_RS28805_lanthipeptide
1
A R G D G C G P W R S G L R C P S G K E E P L
23
+ D G C G S C +G K P
6
S T S D G C G S S C S N S A C T T G K N T P F
28
32.1%
NZ_KB905816.1 and 1 other:
NZ_KB905816.1 Lanthipeptides: F603_RS35860_lanthipeptide
Lanthipeptides: F603_RS35860_lanthipeptide
4
D G C G P W R S G L R C P S G K E E P
22
D G C G S G C S ++P
9
D G C G S T C S G S A C N S F T D D P
27
28.6%
NC_013929.1 and 11 others:
NC_013929.1 Lanthipeptides: SCAB_RS44850_lanthipeptide NZ_CP024989.1 Lanthipeptides: CVT30_RS13845_lanthipeptide NZ_CP024989.1 Lanthipeptides: CVT30_RS13845_lanthipeptide NZ_CP024989.1 Lanthipeptides: CVT30_RS13845_lanthipeptide NZ_CP043956.1 Lanthipeptides: F3K20_RS28980_lanthipeptide NZ_CP043956.1 Lanthipeptides: F3K20_RS28980_lanthipeptide NZ_CP119182.1 Lanthipeptides: IHE65_RS14995_lanthipeptide NZ_CP119182.1 Lanthipeptides: IHE65_RS14995_lanthipeptide NZ_JABXWH010000012.1 Lanthipeptides: HW845_RS28550_lanthipeptide NZ_JABXWH010000012.1 Lanthipeptides: HW845_RS28550_lanthipeptide NZ_KL997517.1 Lanthipeptides: IQ61_RS45045_lanthipeptide
Lanthipeptides: SCAB_RS44850_lanthipeptide
4
D G C G P W R S G L R C P S G K E E P
22
D C G S G C S +P
8
D N C G S T C S G T A C A S F T G D P
26
28.6%
NZ_CM001439.1 and 5 others:
NZ_CM001439.1 Lanthipeptides: SACMADRAFT_RS20585_lanthipeptide NZ_CP059997.1 Lanthipeptides: HUW46_RS22770_lanthipeptide NZ_CP059997.1 Lanthipeptides: HUW46_RS22770_lanthipeptide NZ_CP090063.1 Lanthipeptides: LWP59_RS37700_lanthipeptide NZ_CP090063.1 Lanthipeptides: LWP59_RS37700_lanthipeptide
Lanthipeptides: SACMADRAFT_RS20585_lanthipeptide
4
D G C G P W R S G L R C P S G K E E P L
23
D C G G C S P L
7
D N C G G T T C G S A C T S H V A T P L
26
28.6%
NZ_CP054919.1 and 1 other:
NZ_CP054919.1 Lanthipeptides: HUT16_RS27255_lanthipeptide
Lanthipeptides: HUT16_RS27255_lanthipeptide
4
D G C G P W R S G L R C P S G
18
D G C G G C S G
9
D G C G S T C E G S A C A S G
23
28.6%
NZ_CP076538.1 and 1 other:
NZ_CP076538.1 Lanthipeptides: KOI47_RS17130_lanthipeptide
Lanthipeptides: KOI47_RS17130_lanthipeptide
4
D G C G P W R S G L R C P S G K E E P
22
D G C G S C S P
9
D G C G Q T C S T S A C N S Q A N N P
27
28.6%
NZ_CP113837.1 and 1 other:
NZ_CP113837.1 Lanthipeptides: OU787_RS02725_lanthipeptide
Lanthipeptides: OU787_RS02725_lanthipeptide
4
D G C G P W R S G L R C P S
17
D G C G S G C S
9
D G C G S T C S G T A C T S
22
28.6%
NZ_KI632511.1 and 1 other:
NZ_KI632511.1 Lanthipeptides: ACTRO_RS29755_lanthipeptide
Lanthipeptides: ACTRO_RS29755_lanthipeptide
4
D G C G P W R S G L R C P S G K E E P
22
D G C G S C +G +P
9
D G C G S T C S N S A C A T G S N D P
27
28.6%
NZ_PGGV01000032.1 and 1 other:
NZ_PGGV01000032.1 Lanthipeptides: CUT39_RS12965_lanthipeptide
Lanthipeptides: CUT39_RS12965_lanthipeptide
4
D G C G P W R S G L R C P S G K E E P L
23
D G C G G C S P+
7
D G C G N T C Q G S A C A S F T N N P V
26
28.6%
NZ_PVZV01000003.1 and 1 other:
NZ_PVZV01000003.1 Lanthipeptides: C2865_RS14135_lanthipeptide
Lanthipeptides: C2865_RS14135_lanthipeptide
1
A R G D G C G P W R S G L R C P S G K E E P L
23
+ D G C G C S G P+
5
S T S D G C G S T C Q T S A C N S G V A N P V
27
allorf_4766677_4766784
Leader:
MRNHVTIAGA
Core:
C K K F P S K R H A S V E D M P R P L V N L P Q T
Core with dehydrations:
Cys K K F P Dha K R H A Dha V E D M P R P L V N L P Q Dhb

#### antiSMASH-DB 4.0 matches for allorf_4766677_4766784

100.0%
NZ_CP077072.1:
Lanthipeptides: allorf_4766677_4766784_lanthipeptide
1
C K K F P S K R H A S V E D M P R P L V N L P Q T
25
C K K F P S K R H A S V E D M P R P L V N L P Q T
1
C K K F P S K R H A S V E D M P R P L V N L P Q T
25
24.3%
NZ_KB235948.1 and 1 other:
NZ_KB235948.1 Lanthipeptides: allorf_4821822_4821968_lanthipeptide
Lanthipeptides: allorf_4821822_4821968_lanthipeptide
1
C K K F P S K R H A S V E D M P R P
18
C+K P R S+ D P R P
8
C Q K E P R T R--S L A D F P R P
23
24.0%
NZ_JAGGRJ010000031.1:
Lanthipeptides: allorf_023920_024030_lanthipeptide
10
A S V E D M P R P L V N
21
A++E D+ R P+ N
2
A A I E D L S R P V W N
13
allorf_4767256_4767366
Leader:
MRHERSRAGA
Core:
L L Q R I R T T T P Y P C R S A P R A R P V E R E R
Core with dehydrations:
L L Q R I R Dhb Dhb Dhb P Y P Cys R Dha A P R A R P V E R E R

#### antiSMASH-DB 4.0 matches for allorf_4767256_4767366

100.0%
NZ_CP077072.1:
Lanthipeptides: allorf_4767256_4767366_lanthipeptide
1
L L Q R I R T T T P Y P C R S A P R A R P V E R E R
26
L L Q R I R T T T P Y P C R S A P R A R P V E R E R
1
L L Q R I R T T T P Y P C R S A P R A R P V E R E R
26
38.5%
NZ_CP077072.1:
Lanthipeptides: allorf_2541699_2541854_lanthipeptide
12
P C R S A P R A R P V
22
P C R S A P R A R P+
6
P C R S A P R A R P I
16
23.3%
NZ_SNYR01000002.1:
Lanthipeptides: allorf_843846_843965_lanthipeptide
1
L L Q R I R T T T P Y P C-R S A P R A R P V E R
24
L+++I R P C +++P ++R
3
L I E K I R N A G A L P C A Q T S P E G E L I K R
27
with 4 more sequence matches
21.4%
NZ_JADKRR010000001.1:
Lanthipeptides: allorf_2139491_2139706_lanthipeptide
6
R T T T P Y P C R S A P R A R P V E R E R
26
R T T T + A P R A R P R R
32
R T T T----K Q A P R A R P A C R N R
48
21.3%
NZ_LMFT01000038.1:
Lanthipeptides: allorf_010542_010721_lanthipeptide
6
R T T T P Y P C R S A P R A R P V E R E R
26
R T T P+P R S+ P R R
23
R T T G P H P P R S S D E R S P G P R S R
43
21.1%
NZ_CP026490.1:
Lanthipeptides: allorf_0208403_0208621_lanthipeptide
4
R I R T T T P Y P C R S A P R A
19
R+R T T P R P+A
16
R L R A T T Q V P V R Q C P K A
31
12.1%
NZ_JANVAG010000003.1:
Lanthipeptides: allorf_432453_432671_lanthipeptide
13
C R S A P R A R P V E R E
25
C R P R P V+R
8
C R H L P S Q R P V Q R H
20
allorf_4771891_4772103
Leader:
MDSFATTGRAQARSYRWECYRRCLSGSGASGHGRAQGA
Core:
L L H W A V S A A I S L C C L L Q R P G W G S G N L G R F P I H
Core with dehydrations:
L L H W A V Dha A A I Dha L Cys Cys L L Q R P G W G Dha G N L G R F P I H

#### antiSMASH-DB 4.0 matches for allorf_4771891_4772103

100.0%
NZ_CP077072.1:
Lanthipeptides: allorf_4771891_4772103_lanthipeptide
1
L L H W A V S A A I S L C C L L Q R P G W G S G N L G R F P I H
32
L L H W A V S A A I S L C C L L Q R P G W G S G N L G R F P I H
1
L L H W A V S A A I S L C C L L Q R P G W G S G N L G R F P I H
32
21.9%
NZ_JACSCH020000010.1:
Lanthipeptides: E0F75_RS21605_lanthipeptide
22
G S G N L G R F P I H
32
G+G+L G R P I
2
G A G S L G R A P I R
12
14.0%
NZ_BMUU01000006.1 and 2 others:
NZ_BMUZ01000004.1 Lanthipeptides: IE267_RS12230_lanthipeptide NZ_CP070373.1 Lanthipeptides: GWQ54_RS15580_lanthipeptide
Lanthipeptides: IE233_RS19525_lanthipeptide
18
R P G W G S G N L G R F P I H
32
P G S G N L + P+H
16
S P G V A S G N L V Q I P V H
30
with 1 more sequence matches
13.8%
NZ_CP003987.1:
Lanthipeptides: allorf_00516755_00516991_lanthipeptide
11
S L C C L L Q R P G W G S G N L G R
28
S +R P G G S G L R
3
S R A T T S R R P G R G S G E L A R
20

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.31 out of 18.57
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.33 out of 27.78
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16
Confidence: strong
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 23.62 out of 29.72
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 20.10 out of 21.84
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.18 out of 20.47
Confidence: medium
Additional weak hits (4):
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.70 out of 26.33
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.75 out of 33.14
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.33 out of 36.53
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.43 out of 28.19
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

KR767_RS20375 - Class II
  Cleavage pHMM score: -3.10
  RODEO score: 0
  Monoisotopic mass: 2362.2 Da
  Molecular weight: 2363.8 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2381.8 Da N = 1
    2399.8 Da N = 2
    2417.8 Da N = 3
    2435.8 Da N = 4
KR767_RS20380 - Class II
  Cleavage pHMM score: -3.10
  RODEO score: 0
  Monoisotopic mass: 2674.3 Da
  Molecular weight: 2676.1 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2694.1 Da N = 1
    2712.1 Da N = 2
allorf_4753534_4753761 - Class II
  Cleavage pHMM score: -5.30
  RODEO score: 0
  Monoisotopic mass: 4450.5 Da
  Molecular weight: 4453.4 Da
  Number of bridges: 3
allorf_4755020_4755199 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 2919.4 Da
  Molecular weight: 2921.3 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2939.3 Da N = 1
allorf_4766677_4766784 - Class II
  Cleavage pHMM score: -0.50
  RODEO score: 0
  Monoisotopic mass: 2823.5 Da
  Molecular weight: 2825.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2843.3 Da N = 1
    2861.3 Da N = 2
allorf_4767256_4767366 - Class II
  Cleavage pHMM score: -6.40
  RODEO score: 0
  Monoisotopic mass: 3049.7 Da
  Molecular weight: 3051.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3069.5 Da N = 1
    3087.6 Da N = 2
    3105.6 Da N = 3
allorf_4771891_4772103 - Class II
  Cleavage pHMM score: -7.20
  RODEO score: 0
  Monoisotopic mass: 3417.8 Da
  Molecular weight: 3420.0 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3438.0 Da N = 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MexT | Global virulence regulator
NtrC | Nitrogen regulatory protein C
ToxT | Regulator of MSHA biosynthesis
VqsM | Regulator of quorum-sensing signalling systems