Select genomic region:
Overview
3.1
8.1
11.1
12.1
33.1
33.2
44.1
44.2
51.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_JAGSCE010000012.1 (Staphylococcus aureus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 3.1 | RiPP-like | 53,037 | 63,321 |

NZ_JAGSCE010000017.1 (Staphylococcus aureus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 8.1 | cyclic-lactone-autoinducer | 2,469 | 23,176 |

NZ_JAGSCE010000001.1 (Staphylococcus aureus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 11.1 | terpene-precursor | 157,865 | 178,746 |

NZ_JAGSCE010000020.1 (Staphylococcus aureus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 12.1 | lanthipeptide-class-i | 32,452 | 47,482 | High | hyicin 3682 | ribosomal:RiPP

NZ_JAGSCE010000003.1 (Staphylococcus aureus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 33.1 | NI-siderophore | 10,728 | 45,216 | High | staphyloferrin B | other:other
Region 33.2 | NRPS | 69,257 | 116,432 | High | aureusimine A/aureusimine B/aureusimine C | NRPS:Type I

NZ_JAGSCE010000004.1 (Staphylococcus aureus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 44.1 | terpene,T3PKS,epipeptide | 8,867 | 72,027 |
Region 44.2 | opine-like-metallophore | 110,266 | 132,378 | High | staphylopine | other:other

NZ_JAGSCE010000008.1 (Staphylococcus aureus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 51.1 | NI-siderophore | 82,006 | 115,021 | High | staphyloferrin A | other:non-nrp siderophore

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 3.1 | RiPP-like | 53,037 | 63,321 |
Region 8.1 | cyclic-lactone-autoinducer | 2,469 | 23,176 |
Region 11.1 | terpene-precursor | 157,865 | 178,746 |
Region 12.1 | lanthipeptide-class-i | 32,452 | 47,482 | High | hyicin 3682 | ribosomal:RiPP
Region 33.1 | NI-siderophore | 10,728 | 45,216 | High | staphyloferrin B | other:other
Region 33.2 | NRPS | 69,257 | 116,432 | High | aureusimine A/aureusimine B/aureusimine C | NRPS:Type I
Region 44.1 | terpene,T3PKS,epipeptide | 8,867 | 72,027 |
Region 44.2 | opine-like-metallophore | 110,266 | 132,378 | High | staphylopine | other:other
Region 51.1 | NI-siderophore | 82,006 | 115,021 | High | staphyloferrin A | other:non-nrp siderophore

No secondary metabolite regions were found in these records:
  NZ_JAGSCE010000010.1 (Staphylococcus aureus)
  NZ_JAGSCE010000011.1 (Staphylococcus aureus)
  NZ_JAGSCE010000013.1 (Staphylococcus aureus)
  NZ_JAGSCE010000014.1 (Staphylococcus aureus)
  NZ_JAGSCE010000015.1 (Staphylococcus aureus)
  NZ_JAGSCE010000016.1 (Staphylococcus aureus)
  NZ_JAGSCE010000018.1 (Staphylococcus aureus)
  NZ_JAGSCE010000019.1 (Staphylococcus aureus)
  NZ_JAGSCE010000021.1 (Staphylococcus aureus)
  NZ_JAGSCE010000022.1 (Staphylococcus aureus)
  NZ_JAGSCE010000023.1 (Staphylococcus aureus)
  NZ_JAGSCE010000024.1 (Staphylococcus aureus)
  NZ_JAGSCE010000025.1 (Staphylococcus aureus)
  NZ_JAGSCE010000026.1 (Staphylococcus aureus)
  NZ_JAGSCE010000027.1 (Staphylococcus aureus)
  NZ_JAGSCE010000028.1 (Staphylococcus aureus)
  NZ_JAGSCE010000029.1 (Staphylococcus aureus)
  NZ_JAGSCE010000002.1 (Staphylococcus aureus)
  NZ_JAGSCE010000030.1 (Staphylococcus aureus)
  NZ_JAGSCE010000031.1 (Staphylococcus aureus)
  NZ_JAGSCE010000032.1 (Staphylococcus aureus)
  NZ_JAGSCE010000033.1 (Staphylococcus aureus)
  NZ_JAGSCE010000034.1 (Staphylococcus aureus)
  NZ_JAGSCE010000035.1 (Staphylococcus aureus)
  NZ_JAGSCE010000036.1 (Staphylococcus aureus)
  NZ_JAGSCE010000037.1 (Staphylococcus aureus)
  NZ_JAGSCE010000038.1 (Staphylococcus aureus)
  NZ_JAGSCE010000039.1 (Staphylococcus aureus)
  NZ_JAGSCE010000040.1 (Staphylococcus aureus)
  NZ_JAGSCE010000041.1 (Staphylococcus aureus)
  NZ_JAGSCE010000042.1 (Staphylococcus aureus)
  NZ_JAGSCE010000043.1 (Staphylococcus aureus)
  NZ_JAGSCE010000044.1 (Staphylococcus aureus)
  NZ_JAGSCE010000045.1 (Staphylococcus aureus)
  NZ_JAGSCE010000046.1 (Staphylococcus aureus)
  NZ_JAGSCE010000047.1 (Staphylococcus aureus)
  NZ_JAGSCE010000048.1 (Staphylococcus aureus)
  NZ_JAGSCE010000049.1 (Staphylococcus aureus)
  NZ_JAGSCE010000050.1 (Staphylococcus aureus)
  NZ_JAGSCE010000051.1 (Staphylococcus aureus)
  NZ_JAGSCE010000052.1 (Staphylococcus aureus)
  NZ_JAGSCE010000005.1 (Staphylococcus aureus)
  NZ_JAGSCE010000006.1 (Staphylococcus aureus)
  NZ_JAGSCE010000007.1 (Staphylococcus aureus)
  NZ_JAGSCE010000009.1 (Staphylococcus aureus)

Compact view
NZ_JAGSCE010000012.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 53,037 - 63,321 nt. (total: 10,285 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000626.3 |  | 0.36 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001229.4 |  | 0.36 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0002442.3 |  | 0.35 | ribosomal | toyoncin | Bacillus toyonensis
BGC0002656.2 |  | 0.33 | PKS | oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B | Streptacidiphilus oryzae TH49
BGC0002116.3 |  | 0.33 | ribosomal | darobactin A | Photorhabdus khanii HGB 1456
BGC0002447.3 |  | 0.31 | ribosomal | cerecyclin | Bacillus cereus
BGC0002110.3 |  | 0.31 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000487.5 |  | 0.31 | ribosomal | carnocyclin | Carnobacterium maltaromaticum
BGC0000488.4 |  | 0.29 | ribosomal | circularin A | Clostridium beijerinckii
BGC0000323.5 |  | 0.28 | NRPS | cichofactin A, cichofactin B | Pseudomonas cichorii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000626.3 |  | 0.36 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001229.4 |  | 0.36 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0002442.3 |  | 0.35 | ribosomal | toyoncin | Bacillus toyonensis
BGC0002656.2 |  | 0.33 | PKS | oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B | Streptacidiphilus oryzae TH49
BGC0002116.3 |  | 0.33 | ribosomal | darobactin A | Photorhabdus khanii HGB 1456
BGC0002447.3 |  | 0.31 | ribosomal | cerecyclin | Bacillus cereus
BGC0002110.3 |  | 0.31 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000487.5 |  | 0.31 | ribosomal | carnocyclin | Carnobacterium maltaromaticum
BGC0000488.4 |  | 0.29 | ribosomal | circularin A | Clostridium beijerinckii
BGC0000323.5 |  | 0.28 | NRPS | cichofactin A, cichofactin B | Pseudomonas cichorii

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.83 out of 26.06
Confidence: strong
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.93 out of 26.33
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.71 out of 27.78
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.28 out of 18.16
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.38 out of 27.78
Confidence: strong
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 21.07 out of 25.31
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.83 out of 27.78
Confidence: medium
Additional weak hits (3):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.81 out of 27.04
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.94 out of 36.54
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
AbrC3 | Antibiotic production activator
CatR | H2O2-responsive repressor
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes

NZ_JAGSCE010000017.1 - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,469 - 23,176 nt. (total: 20,708 nt) Show pHMM detection rules used
Region on contig edge.
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: kinase
KC252_RS09570: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

Lyases: hydratase
KC252_RS09605: Nitrilase/cyanide hydratase and apolipoprotein

smcogs
  SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002667.2 |  | 0.42 | ribosomal | estericin A | Clostridium estertheticum
BGC0001687.3 |  | 0.39 | other (other) | N-tetradecanoyl tyrosine | uncultured bacterium CSL12
BGC0002579.2 |  | 0.39 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0000624.3 |  | 0.30 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000207.5 |  | 0.30 | PKS | chartreusin | Streptomyces chartreusis
BGC0001872.3 |  | 0.30 | PKS | fabclavine-polyamine | Xenorhabdus bovienii SS-2004
BGC0001053.5 |  | 0.29 | NRPS, PKS | tubulysin A | Archangium disciforme
BGC0001130.5 |  | 0.27 | NRPS, PKS | fabclavine Ia, fabclavine Ib, fabclavine IIa, fabclavine IIb | Xenorhabdus budapestensis
BGC0001700.5 |  | 0.23 | PKS | niphimycin C, niphimycin D, niphimycin E, 17-O-methylniphimycin, niphimycin Iα, 19-O-malonylniphimycin | Streptomyces sp. IMB7-145
BGC0000082.5 |  | 0.22 | PKS | kijanimicin | Actinomadura kijaniata

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002667.2 |  | 0.42 | ribosomal | estericin A | Clostridium estertheticum
BGC0001687.3 |  | 0.39 | other (other) | N-tetradecanoyl tyrosine | uncultured bacterium CSL12
BGC0002579.2 |  | 0.39 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0000624.3 |  | 0.30 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000207.5 |  | 0.30 | PKS | chartreusin | Streptomyces chartreusis
BGC0001872.3 |  | 0.30 | PKS | fabclavine-polyamine | Xenorhabdus bovienii SS-2004
BGC0001053.5 |  | 0.29 | NRPS, PKS | tubulysin A | Archangium disciforme
BGC0001130.5 |  | 0.27 | NRPS, PKS | fabclavine Ia, fabclavine Ib, fabclavine IIa, fabclavine IIb | Xenorhabdus budapestensis
BGC0001700.5 |  | 0.23 | PKS | niphimycin C, niphimycin D, niphimycin E, 17-O-methylniphimycin, niphimycin Iα, 19-O-malonylniphimycin | Streptomyces sp. IMB7-145
BGC0000082.5 |  | 0.22 | PKS | kijanimicin | Actinomadura kijaniata

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.02 out of 21.84
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.53 out of 28.19
Confidence: medium
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 22.68 out of 27.04
Confidence: medium
Additional weak hits (2):
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.26 out of 30.11
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
DasR | N-acetylglucosamine dependent repressor
MexT | Global virulence regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_JAGSCE010000001.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 157,865 - 178,746 nt. (total: 20,882 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
KC252_RS00680: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: carboxylase
KC252_RS00720: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Hydrolases: peptidase
KC252_RS00735: methionine aminopeptidase

smcogs
  SMCOG1172: methionine aminopeptidase

Ligases: synthase synthetase
KC252_RS00670: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

KC252_RS00695: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001534.3 |  | 0.54 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0001535.3 |  | 0.44 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000234.5 |  | 0.42 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0002284.3 |  | 0.40 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0001605.3 |  | 0.40 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000905.5 |  | 0.40 | other (other) | heme D1 | Heliobacillus mobilis
BGC0000906.3 |  | 0.40 | other (other) | heme D1 | Heliophilum fasciatum
BGC0001529.5 |  | 0.40 | other (other) | benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K | Streptomyces sp. RI18

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001534.3 |  | 0.54 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0001535.3 |  | 0.44 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000234.5 |  | 0.42 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0002284.3 |  | 0.40 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0001605.3 |  | 0.40 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000905.5 |  | 0.40 | other (other) | heme D1 | Heliobacillus mobilis
BGC0000906.3 |  | 0.40 | other (other) | heme D1 | Heliophilum fasciatum
BGC0001529.5 |  | 0.40 | other (other) | benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K | Streptomyces sp. RI18

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
KC252_RS00695: PT_FPPS_like
Domain 1 (30 - 293): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.78 out of 18.16
Confidence: strong
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.41 out of 23.79
Confidence: medium
Additional weak hits (3):
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.52 out of 33.73
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.06 out of 25.88
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.88 out of 31.73
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
IolR | Regulator of the inositol catabolism

NZ_JAGSCE010000020.1 - Region 1 - lanthipeptide-class-i
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 32,452 - 47,482 nt. (total: 15,031 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
KC252_RS10470: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase dehydratase
KC252_RS10480: Lanthionine synthetase C family protein

smcogs
  SMCOG1140: Lanthionine synthetase C family protein

KC252_RS10485: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-i | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001618.3 |  | 0.79 | ribosomal | hyicin 3682 | Staphylococcus hyicus
BGC0002576.2 |  | 0.74 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0000508.3 |  | 0.62 | ribosomal | epidermin | Staphylococcus epidermidis
BGC0000533.3 |  | 0.54 | ribosomal | mutacin III | Streptococcus mutans
BGC0000530.5 |  | 0.53 | ribosomal | mutacin B-Ny266 | Streptococcus mutans N66
BGC0000514.5 |  | 0.53 | ribosomal | gallidermin | Staphylococcus gallinarum
BGC0000531.3 |  | 0.52 | ribosomal | mutacin I | Streptococcus mutans
BGC0000537.3 |  | 0.49 | ribosomal | nisin U | Streptococcus uberis
BGC0000541.5 |  | 0.49 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000542.3 |  | 0.49 | ribosomal | paenicidin B | Paenibacillus terrae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001618.3 |  | 0.79 | ribosomal | hyicin 3682 | Staphylococcus hyicus
BGC0002576.2 |  | 0.74 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0000508.3 |  | 0.62 | ribosomal | epidermin | Staphylococcus epidermidis
BGC0000533.3 |  | 0.54 | ribosomal | mutacin III | Streptococcus mutans
BGC0000530.5 |  | 0.53 | ribosomal | mutacin B-Ny266 | Streptococcus mutans N66
BGC0000514.5 |  | 0.53 | ribosomal | gallidermin | Staphylococcus gallinarum
BGC0000531.3 |  | 0.52 | ribosomal | mutacin I | Streptococcus mutans
BGC0000537.3 |  | 0.49 | ribosomal | nisin U | Streptococcus uberis
BGC0000541.5 |  | 0.49 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000542.3 |  | 0.49 | ribosomal | paenicidin B | Paenibacillus terrae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for KC252_RS10485

KC252_RS10490
Leader:
MENVLDLDVQVKAKNDTSDSA
Core:
G D E R I T S F I G C T P G C G K T G S F N S F C C
Core with dehydrations:
G D E R I Dhb Dha F I G Cys Dhb P G Cys G K Dhb G Dha F N Dha F Cys Cys

#### antiSMASH-DB 4.0 matches for KC252_RS10490

100.0%
NC_007622.1 and 12 others:
NC_017337.1 Lanthipeptides: SAOV_RS09475_lanthipeptide NZ_CP010941.1 Lanthipeptides: UC16_RS09555_lanthipeptide NZ_CP038268.1 Lanthipeptides: SaO55_RS09715_lanthipeptide NZ_CP042650.1 Lanthipeptides: FTD94_RS09865_lanthipeptide NZ_CP065857.1 Lanthipeptides: I1A60_RS09290_lanthipeptide NZ_CP094743.1 Lanthipeptides: MUA62_RS09290_lanthipeptide NZ_CP096114.1 Lanthipeptides: M0D62_RS09005_lanthipeptide NZ_CP102957.1 Lanthipeptides: NW959_RS08715_lanthipeptide NZ_GG730342.1 Lanthipeptides: SAUG_RS17375_lanthipeptide NZ_JAGSAD010000008.1 Lanthipeptides: KC182_RS10520_lanthipeptide NZ_JAGSCE010000020.1 Lanthipeptides: KC252_RS10490_lanthipeptide NZ_KZ984531.1 Lanthipeptides: AHP18_RS05855_lanthipeptide
Lanthipeptides: SAB_RS08990_lanthipeptide
1
G D E R I T S F I G C T P G C G K T G S F N S F C C
26
G D E R I T S F I G C T P G C G K T G S F N S F C C
1
G D E R I T S F I G C T P G C G K T G S F N S F C C
26
88.5%
NZ_CP102975.1:
Lanthipeptides: NW953_RS09010_lanthipeptide
4
R I T S F I G C T P G C G K T G S F N S F C C
26
R I T S F I G C T P G C G K T G S F N S F C C
1
R I T S F I G C T P G C G K T G S F N S F C C
23
84.6%
NZ_LR134304.1:
Lanthipeptides: EL116_RS09245_lanthipeptide
4
R I T S F I G C T P G C G K T G S F N S F C C
26
R I T S I G C T P G C G K T G S F N S F C C
1
R I T S V I G C T P G C G K T G S F N S F C C
23
with 91 more sequence matches
Only the first 10 are displayed here.
76.9%
NZ_CP023076.1:
Lanthipeptides: CJ017_RS08945_lanthipeptide
3
E R I T S F I G C T P G C G K T G S F N S F C C
26
E R I T S C T P G C K T G S F N S F C C
1
E R I T S H S L C T P G C A K T G S F N S F C C
24
76.9%
NZ_VKCY01000012.1:
Lanthipeptides: FNK43_RS09020_lanthipeptide
3
E R I T S F I G C T P G C G K T G S F N S F C C
26
E R I T S F C T P G C K T G S F N S+C C
1
E R I T S F S L C T P G C A K T G S F N S Y C C
24
73.1%
NC_003923.1 and 8 others:
NC_009641.1 Lanthipeptides: NWMN_RS09635_lanthipeptide NZ_CP054876.1 Lanthipeptides: HUW54_RS09150_lanthipeptide NZ_CP077098.1 Lanthipeptides: KSF82_RS09475_lanthipeptide NZ_CP092781.1 Lanthipeptides: ML436_RS08940_lanthipeptide NZ_CP102959.1 Lanthipeptides: NW979_RS08780_lanthipeptide NZ_CP102962.1 Lanthipeptides: NW971_RS09555_lanthipeptide NZ_LR133917.1 Lanthipeptides: ELZ45_RS09155_lanthipeptide NZ_LS483317.1 Lanthipeptides: DQL75_RS09700_lanthipeptide
Lanthipeptides: MW_RS09420_lanthipeptide
4
R I T S F I G C T P G C G K T G S F N S F C C
26
R I T S C T P G C K T G S F N S F C C
1
R I T S H S L C T P G C A K T G S F N S F C C
23
69.2%
NC_007622.1 and 1 other:
NZ_LR133917.1 Lanthipeptides: ELZ45_RS09165_lanthipeptide
Lanthipeptides: SAB_RS08995_lanthipeptide
4
R I T S F I G C T P G C G K T G S F N S F C C
26
R I T S C+ G C G K T G S F N S F C C
1
R I T S H F L C S F G C G K T G S F N S F C C
23
69.2%
NC_022873.1 and 92 others:
NZ_CM000742.1 Lanthipeptides: BMYCO0001_RS26515_lanthipeptide NZ_CP011151.1 Lanthipeptides: WR47_RS18180_lanthipeptide NZ_CP011151.1 Lanthipeptides: WR47_RS18175_lanthipeptide NZ_CP011151.1 Lanthipeptides: WR47_RS18170_lanthipeptide NZ_CP011151.1 Lanthipeptides: WR47_RS18165_lanthipeptide NZ_CP015350.1 Lanthipeptides: BT246_RS19775_lanthipeptide NZ_CP015350.1 Lanthipeptides: BT246_RS19770_lanthipeptide NZ_CP015350.1 Lanthipeptides: BT246_RS19765_lanthipeptide NZ_CP017060.1 Lanthipeptides: FORC47_RS18710_lanthipeptide NZ_CP017060.1 Lanthipeptides: FORC47_RS18705_lanthipeptide NZ_CP017060.1 Lanthipeptides: FORC47_RS18700_lanthipeptide NZ_CP026678.1 Lanthipeptides: C2I25_RS21370_lanthipeptide NZ_CP026678.1 Lanthipeptides: C2I25_RS21365_lanthipeptide NZ_CP026678.1 Lanthipeptides: C2I25_RS21360_lanthipeptide NZ_CP035965.1 Lanthipeptides: EXW35_RS16385_lanthipeptide NZ_CP035965.1 Lanthipeptides: EXW35_RS16380_lanthipeptide NZ_CP035994.1 Lanthipeptides: EXW32_RS16155_lanthipeptide NZ_CP035994.1 Lanthipeptides: EXW32_RS16150_lanthipeptide NZ_CP035994.1 Lanthipeptides: EXW32_RS16145_lanthipeptide NZ_CP035994.1 Lanthipeptides: EXW32_RS16140_lanthipeptide NZ_CP035999.1 Lanthipeptides: EXW27_RS26195_lanthipeptide NZ_CP035999.1 Lanthipeptides: EXW27_RS26190_lanthipeptide NZ_CP035999.1 Lanthipeptides: EXW27_RS26185_lanthipeptide NZ_CP035999.1 Lanthipeptides: EXW27_RS26180_lanthipeptide NZ_CP036099.1 Lanthipeptides: EXW47_RS16265_lanthipeptide NZ_CP036099.1 Lanthipeptides: EXW47_RS16260_lanthipeptide NZ_CP036099.1 Lanthipeptides: EXW47_RS16255_lanthipeptide NZ_CP036099.1 Lanthipeptides: EXW47_RS16250_lanthipeptide NZ_CP036117.1 Lanthipeptides: EXW43_RS16620_lanthipeptide NZ_CP036117.1 Lanthipeptides: EXW43_RS16615_lanthipeptide NZ_CP036117.1 Lanthipeptides: EXW43_RS16610_lanthipeptide NZ_CP036117.1 Lanthipeptides: EXW43_RS16605_lanthipeptide NZ_CP036145.1 Lanthipeptides: EXW57_RS16110_lanthipeptide NZ_CP036145.1 Lanthipeptides: EXW57_RS16105_lanthipeptide NZ_CP036145.1 Lanthipeptides: EXW57_RS16100_lanthipeptide NZ_CP036145.1 Lanthipeptides: EXW57_RS16095_lanthipeptide NZ_CP040334.1 Lanthipeptides: EUC39_RS14125_lanthipeptide NZ_CP040334.1 Lanthipeptides: EUC39_RS14120_lanthipeptide NZ_CP040334.1 Lanthipeptides: EUC39_RS14115_lanthipeptide NZ_CP045606.2 Lanthipeptides: GE376_RS18355_lanthipeptide NZ_CP045606.2 Lanthipeptides: GE376_RS18350_lanthipeptide NZ_CP045606.2 Lanthipeptides: GE376_RS18345_lanthipeptide NZ_CP047366.1 Lanthipeptides: GSN03_RS15835_lanthipeptide NZ_CP047366.1 Lanthipeptides: GSN03_RS15830_lanthipeptide NZ_CP071811.1 Lanthipeptides: EXW36_RS16415_lanthipeptide NZ_CP071811.1 Lanthipeptides: EXW36_RS16410_lanthipeptide NZ_CP071811.1 Lanthipeptides: EXW36_RS16405_lanthipeptide NZ_CP072061.1 Lanthipeptides: J5V93_RS15130_lanthipeptide NZ_CP072061.1 Lanthipeptides: J5V93_RS15125_lanthipeptide NZ_CP072061.1 Lanthipeptides: J5V93_RS15120_lanthipeptide NZ_CP084035.1 Lanthipeptides: LCF45_RS15990_lanthipeptide NZ_CP084035.1 Lanthipeptides: LCF45_RS15985_lanthipeptide NZ_CP084035.1 Lanthipeptides: LCF45_RS15980_lanthipeptide NZ_CP084035.1 Lanthipeptides: LCF45_RS15975_lanthipeptide NZ_CP093291.1 Lanthipeptides: MN093_RS25975_lanthipeptide NZ_CP093291.1 Lanthipeptides: MN093_RS25970_lanthipeptide NZ_CP093291.1 Lanthipeptides: MN093_RS25965_lanthipeptide NZ_CP093291.1 Lanthipeptides: MN093_RS25960_lanthipeptide NZ_CP093835.1 Lanthipeptides: MN034_RS15810_lanthipeptide NZ_CP093835.1 Lanthipeptides: MN034_RS15805_lanthipeptide NZ_CP093835.1 Lanthipeptides: MN034_RS15800_lanthipeptide NZ_CP093835.1 Lanthipeptides: MN034_RS15795_lanthipeptide NZ_JAIPUK010000008.1 Lanthipeptides: K9P71_RS24265_lanthipeptide NZ_JAIPUK010000008.1 Lanthipeptides: K9P71_RS24260_lanthipeptide NZ_JANCTB010000001.1 Lanthipeptides: NMG90_RS06155_lanthipeptide NZ_JANCTB010000001.1 Lanthipeptides: NMG90_RS06150_lanthipeptide NZ_JANCTB010000001.1 Lanthipeptides: NMG90_RS06145_lanthipeptide NZ_JANCTB010000001.1 Lanthipeptides: NMG90_RS06140_lanthipeptide NZ_JH792114.1 Lanthipeptides: II3_RS21535_lanthipeptide NZ_JH792114.1 Lanthipeptides: II3_RS21530_lanthipeptide NZ_JH792114.1 Lanthipeptides: II3_RS21525_lanthipeptide NZ_JH792251.1 Lanthipeptides: III_RS11095_lanthipeptide NZ_JH792251.1 Lanthipeptides: III_RS11090_lanthipeptide NZ_JH792251.1 Lanthipeptides: III_RS11085_lanthipeptide NZ_JH792251.1 Lanthipeptides: III_RS11080_lanthipeptide NZ_JH792251.1 Lanthipeptides: III_RS11075_lanthipeptide NZ_LDGT01000041.1 Lanthipeptides: ABE17_RS18900_lanthipeptide NZ_LDGT01000041.1 Lanthipeptides: ABE17_RS18895_lanthipeptide NZ_LDGT01000041.1 Lanthipeptides: ABE17_RS18890_lanthipeptide NZ_LDGT01000041.1 Lanthipeptides: ABE17_RS18885_lanthipeptide NZ_LDHL01000037.1 Lanthipeptides: ABD98_RS26430_lanthipeptide NZ_LDHL01000037.1 Lanthipeptides: ABD98_RS26425_lanthipeptide NZ_MOOL01000076.1 Lanthipeptides: BK733_RS27280_lanthipeptide NZ_MOOL01000076.1 Lanthipeptides: BK733_RS27275_lanthipeptide NZ_MOOL01000076.1 Lanthipeptides: BK733_RS27270_lanthipeptide NZ_MSTN01000016.1 Lanthipeptides: BVF97_RS28620_lanthipeptide NZ_NIUP01000011.1 Lanthipeptides: CEU84_RS08145_lanthipeptide NZ_NIUP01000011.1 Lanthipeptides: CEU84_RS08140_lanthipeptide NZ_NKAX01000026.1 Lanthipeptides: CE086_RS26165_lanthipeptide NZ_NKAX01000026.1 Lanthipeptides: CE086_RS26160_lanthipeptide NZ_NVGU01000011.1 Lanthipeptides: COL71_RS14760_lanthipeptide NZ_NVGU01000011.1 Lanthipeptides: COL71_RS14755_lanthipeptide
Lanthipeptides: YBT1518_RS19670_lanthipeptide
5
I T S F I G C T P G C G K T G S F N S F C C
26
I T S C T P G C G T G S F N S F C C
1
I T S I S A C T P G C G N T G S F N S F C C
22
69.2%
NZ_CP047792.1 and 1 other:
NZ_JAGSAY010000004.1 Lanthipeptides: KC186_RS06745_lanthipeptide
Lanthipeptides: E3S88_RS07345_lanthipeptide
4
R I T S F I G C T P G C G K T G S F N S F C C
26
R I T S C T P G C T G S F N S F C C
1
R I T S H S L C T P G C A N T G S F N S F C C
23
69.2%
NZ_CP102962.1 and 1 other:
NZ_LS483317.1 Lanthipeptides: DQL75_RS09705_lanthipeptide
Lanthipeptides: NW971_RS09560_lanthipeptide
4
R I T S F I G C T P G C G K T G S F N S F C C
26
R I T S + C+ G C G K T G S F N S F C C
1
R I T S H L L C S F G C G K T G S F N S F C C
23
65.4%
NC_003923.1 and 5 others:
NC_009641.1 Lanthipeptides: NWMN_RS09640_lanthipeptide NZ_CP054876.1 Lanthipeptides: HUW54_RS09155_lanthipeptide NZ_CP077098.1 Lanthipeptides: KSF82_RS09480_lanthipeptide NZ_CP102959.1 Lanthipeptides: NW979_RS08785_lanthipeptide NZ_CP102975.1 Lanthipeptides: NW953_RS09015_lanthipeptide
Lanthipeptides: MW_RS09425_lanthipeptide
4
R I T S F I G C T P G C G K T G S F N S F C C
26
R I T S + C+ G C K T G S F N S F C C
1
R I T S H L F C S F G C E K T G S F N S F C C
23
65.4%
NC_006582.1 and 6 others:
NZ_BOQQ01000001.1 Lanthipeptides: KI354_RS00530_lanthipeptide NZ_BOQS01000001.1 Lanthipeptides: KI364_RS00675_lanthipeptide NZ_CP019985.1 Lanthipeptides: BC8716_RS09795_lanthipeptide NZ_CP104963.1 Lanthipeptides: N7M99_RS07725_lanthipeptide NZ_FRBS01000002.1 Lanthipeptides: BUC05_RS08990_lanthipeptide NZ_JAODPB010000001.1 Lanthipeptides: N6H06_RS03040_lanthipeptide
Lanthipeptides: ABC_RS22115_lanthipeptide
5
I T S F I G C T P G C G K T G S F N S F C C
26
T S C T P G C G+T G S F N S F C C
1
F T S V S F C T P G C G E T G S F N S F C C
22
65.4%
NC_014023.1 and 36 others:
NC_014023.1 Lanthipeptides: BMQ_RS27575_lanthipeptide NZ_CP018875.1 Lanthipeptides: BUW91_RS26425_lanthipeptide NZ_CP018875.1 Lanthipeptides: BUW91_RS26420_lanthipeptide NZ_CP028091.1 Lanthipeptides: C1N54_RS28075_lanthipeptide NZ_CP028091.1 Lanthipeptides: C1N54_RS28070_lanthipeptide NZ_CP028091.1 Lanthipeptides: C1N54_RS28065_lanthipeptide NZ_CP031776.1 Lanthipeptides: D0441_RS30140_lanthipeptide NZ_CP041065.1 Lanthipeptides: FJM50_RS01185_lanthipeptide NZ_CP041065.1 Lanthipeptides: FJM50_RS01180_lanthipeptide NZ_CP041065.1 Lanthipeptides: FJM50_RS01175_lanthipeptide NZ_CP048884.1 Lanthipeptides: BMG_RS27510_lanthipeptide NZ_CP058263.1 Lanthipeptides: HW576_RS26980_lanthipeptide NZ_CP058263.1 Lanthipeptides: HW576_RS26975_lanthipeptide NZ_CP058263.1 Lanthipeptides: HW576_RS26970_lanthipeptide NZ_CP085427.1 Lanthipeptides: LIT30_RS26985_lanthipeptide NZ_CP085427.1 Lanthipeptides: LIT30_RS26980_lanthipeptide NZ_CP085427.1 Lanthipeptides: LIT30_RS26975_lanthipeptide NZ_CP085432.1 Lanthipeptides: LIT34_RS27820_lanthipeptide NZ_CP085432.1 Lanthipeptides: LIT34_RS27815_lanthipeptide NZ_CP085432.1 Lanthipeptides: LIT34_RS27810_lanthipeptide NZ_JACJHT010000009.1 Lanthipeptides: HNP21_RS25635_lanthipeptide NZ_JACJHT010000009.1 Lanthipeptides: HNP21_RS25630_lanthipeptide NZ_JACJHT010000009.1 Lanthipeptides: HNP21_RS25625_lanthipeptide NZ_JAHHYI010000015.1 Lanthipeptides: KM925_RS26245_lanthipeptide NZ_JANIOE010000010.1 Lanthipeptides: NQ109_RS28075_lanthipeptide NZ_JANIOE010000010.1 Lanthipeptides: NQ109_RS28070_lanthipeptide NZ_JANIOE010000010.1 Lanthipeptides: NQ109_RS28065_lanthipeptide NZ_NKAQ01000005.1 Lanthipeptides: CE057_RS19640_lanthipeptide NZ_NKAQ01000005.1 Lanthipeptides: CE057_RS19635_lanthipeptide NZ_NTZG01000054.1 Lanthipeptides: CN510_RS18265_lanthipeptide NZ_NUIN01000020.1 Lanthipeptides: CN973_RS26930_lanthipeptide NZ_NUOI01000090.1 Lanthipeptides: COE08_RS30285_lanthipeptide NZ_NUOI01000090.1 Lanthipeptides: COE08_RS30280_lanthipeptide NZ_NUOQ01000009.1 Lanthipeptides: COE31_RS05925_lanthipeptide NZ_NUXL01000007.1 Lanthipeptides: COJ36_RS20885_lanthipeptide NZ_NUZS01000089.1 Lanthipeptides: COJ90_RS28785_lanthipeptide
Lanthipeptides: BMQ_RS27580_lanthipeptide
5
I T S F I G C T P G C G K T G S F N S F C C
26
I T S C T P G C G T G S+N S F C C
1
I T S V S L C T P G C G D T G S W N S F C C
22

#### MIBiG 4.0 matches for KC252_RS10490

32.4%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
5
I T S F I G C T P G C G K T G S F
21
I T S C T P G C K T G+
1
I T S I S L C T P G C-K T G A L
16

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.53 out of 20.97
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.09 out of 20.97
Confidence: medium
Lanthipeptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

KC252_RS10490 - Class I
  Cleavage pHMM score: 3.70
  RODEO score: 31
  Monoisotopic mass: 2532.1 Da
  Molecular weight: 2533.9 Da
  Number of bridges: 3
  Additional modifications: AviCys
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2551.9 Da N = 1
    2569.9 Da N = 2

RRE predictions
RREfinder results sidepanel.

lanthipeptide-class-i protocluster (32451...47482)
KC252_RS10485
  RRE type: Lanthipeptide_LanB_RRE
  Location: 144 - 237
  Score: 45.8

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A

NZ_JAGSCE010000003.1 - Region 1 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 10,728 - 45,216 nt. (total: 34,489 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
KC252_RS02145: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: glycosyltransferase
KC252_RS02160: sugar transferase

smcogs
  SMCOG1146: sugar transferase

KC252_RS02165: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

Hydrolases: deaminase
KC252_RS02095: ornithine cyclodeaminase

smcogs
  SMCOG1158: ornithine cyclodeaminase

Lyases: decarboxylase dehydratase
KC252_RS02125: diaminopimelate decarboxylase

smcogs
  SMCOG1264: diaminopimelate decarboxylase

KC252_RS02155: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase
KC252_RS02090: cysteine synthase

smcogs
  SMCOG1081: cysteine synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000943.5 |  | 0.97 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000946.5 |  | 0.59 | other (other) | vibrioferrin | Vibrio parahaemolyticus
BGC0000942.4 |  | 0.56 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0002471.3 |  | 0.56 | other (other) | baumannoferrin A, baumannoferrin B | Acinetobacter baumannii AYE
BGC0002073.3 |  | 0.53 | NRPS | dehydroxynocardamine | Corynebacterium propinquum
BGC0002692.2 |  | 0.53 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0000939.5 |  | 0.51 | other (other) | aerobactin | Grimontia hollisae
BGC0000947.5 |  | 0.50 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0001531.5 |  | 0.49 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0000868.5 |  | 0.49 | other (other) | teichuronic acid | Bacillus subtilis subsp. subtilis str. 168

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000943.5 |  | 0.97 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000946.5 |  | 0.59 | other (other) | vibrioferrin | Vibrio parahaemolyticus
BGC0000942.4 |  | 0.56 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0002471.3 |  | 0.56 | other (other) | baumannoferrin A, baumannoferrin B | Acinetobacter baumannii AYE
BGC0002073.3 |  | 0.53 | NRPS | dehydroxynocardamine | Corynebacterium propinquum
BGC0002692.2 |  | 0.53 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0000939.5 |  | 0.51 | other (other) | aerobactin | Grimontia hollisae
BGC0000947.5 |  | 0.50 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0001531.5 |  | 0.49 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0000868.5 |  | 0.49 | other (other) | teichuronic acid | Bacillus subtilis subsp. subtilis str. 168

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.47 out of 26.06
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.84 out of 29.38
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.09 out of 21.55
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.78 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.17 out of 29.38
Confidence: medium
Additional weak hits (5):
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.25 out of 30.97
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.93 out of 32.74
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.51 out of 30.98
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.45 out of 33.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes

NZ_JAGSCE010000003.1 - Region 2 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 69,257 - 116,432 nt. (total: 47,176 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidase phosphate reductase
KC252_RS02325: nucleotide sugar dehydrogenase

smcogs
  SMCOG1152: nucleotide sugar dehydrogenase

KC252_RS02345: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

KC252_RS02415: N-acetyl-gamma-glutamyl-phosphate reductase

smcogs
  SMCOG1219: N-acetyl-gamma-glutamyl-phosphate reductase

KC252_RS02435: pyruvate oxidase/decarboxylase

smcogs
  SMCOG1055: pyruvate oxidase/decarboxylase

Transferases: PPTase acetyltransferase aminotransferase glycosyltransferase kinase phosphotransferase
KC252_RS02300: Chloramphenicol acetyltransferase

smcogs
  SMCOG1156: Chloramphenicol acetyltransferase

KC252_RS02315: sugar transferase

smcogs
  SMCOG1146: sugar transferase

KC252_RS02395: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

KC252_RS02405: acetylglutamate kinase

smcogs
  SMCOG1174: acetylglutamate kinase

KC252_RS02420: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

KC252_RS02445: Glucose-specific phosphotransferase enzyme IIA

smcogs
  SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

Hydrolases: hydrolase
KC252_RS02430: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Lyases: dehydratase
KC252_RS02320: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase
KC252_RS02390: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000308.5 |  | 0.92 | NRPS | aureusimine A, aureusimine B, aureusimine C | Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001135.5 |  | 0.66 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.65 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000307.4 |  | 0.64 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001128.4 |  | 0.64 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.64 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001641.4 |  | 0.63 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.62 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001833.4 |  | 0.61 | NRPS | icosalide A, icosalide B | Burkholderia gladioli

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000308.5 |  | 0.92 | NRPS | aureusimine A, aureusimine B, aureusimine C | Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001135.5 |  | 0.66 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.65 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000307.4 |  | 0.64 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001128.4 |  | 0.64 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.64 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001641.4 |  | 0.63 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.62 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001833.4 |  | 0.61 | NRPS | icosalide A, icosalide B | Burkholderia gladioli

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.63 out of 27.55
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.18 out of 27.78
Confidence: strong
Additional weak hits (11):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.56 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.07 out of 32.74
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.50 out of 30.98
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.38 out of 29.25
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.01 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.55 out of 30.11
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.52 out of 33.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.42 out of 31.73
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.38 out of 29.25
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.77 out of 33.14
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.49 out of 23.43
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 69256 - 116432:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Val - Tyr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KC252_RS02390: Val - Tyr
Search NORINE for peptide: strict or relaxed
AMP-binding (417..807): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LQNGFDAATFEGWLLIGGEINGYGPTENTTFTTT
  Nearest Stachelhaus code(s):
    Val DAFWLGGTFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1442..1834): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LAWAFDASVMECSIITGGAFNAYGPSESTVITSY
  Nearest Stachelhaus code(s):
    Tyr DAMSIGAVIK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes

NZ_JAGSCE010000004.1 - Region 1 - T3PKS,epipeptide,terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 8,867 - 72,027 nt. (total: 63,161 nt) Show pHMM detection rules used
Region on contig edge.
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
epipeptide: (TIGR04078 and yydH)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidase oxidoreductase reductase
KC252_RS02780: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

KC252_RS02795: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

KC252_RS02805: dehydrogenase

smcogs
  SMCOG1072: dehydrogenase

KC252_RS02830: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

KC252_RS02880: hydroxymethylglutaryl-CoA reductase

smcogs
  SMCOG1187: hydroxymethylglutaryl-CoA reductase

KC252_RS02910: pyruvate oxidase/decarboxylase

smcogs
  SMCOG1055: pyruvate oxidase/decarboxylase

KC252_RS03005: dehydrogenase

smcogs
  SMCOG1072: dehydrogenase

KC252_RS03010: dihydropteridine reductase

smcogs
  SMCOG1159: dihydropteridine reductase

Transferases: acetyltransferase acyltransferase aminotransferase phosphotransferase
KC252_RS02765: acyltransferase 3

smcogs
  SMCOG1088: acyltransferase 3

KC252_RS02800: aminotransferase

smcogs
  SMCOG1019: aminotransferase

KC252_RS02825: Chloramphenicol acetyltransferase

smcogs
  SMCOG1156: Chloramphenicol acetyltransferase

KC252_RS02915: Glucose-specific phosphotransferase enzyme IIA

smcogs
  SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

Hydrolases: hydrolase
KC252_RS02930: alpha/beta hydrolase domain-containing protein

smcogs
  SMCOG1066: alpha/beta hydrolase domain-containing protein

KC252_RS03000: hydrolase

smcogs
  SMCOG1179: hydrolase

Ligases: synthase
KC252_RS02875: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

Translocases: transport
KC252_RS02845: MMPL domain-containing transport protein

smcogs
  SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | T3PKS | epipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0000647.3 |  |  |  | 0.38 | terpene | carotenoid | Rhodobacter sphaeroides
BGC0000645.3 |  |  |  | 0.32 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0001636.4 |  |  |  | 0.30 | NRPS | KK-1 | Curvularia clavata
BGC0000656.5 |  |  |  | 0.27 | terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0001184.4 |  |  |  | 0.26 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0001510.5 |  |  |  | 0.22 | other (other) | anisomycin | Streptomyces hygrospinosus
BGC0000646.5 |  |  |  | 0.22 | terpene | β-carotein | uncultured bacterium
BGC0000259.3 |  |  |  | 0.22 | PKS | prodigiosin | Serratia marcescens
BGC0001412.3 |  |  |  | 0.22 | saccharide | polysaccharide C | Bacteroides fragilis
BGC0000641.3 |  |  |  | 0.21 | terpene | carotenoid | Enterobacteriaceae bacterium DC416

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000647.3 |  | 0.57 | terpene | carotenoid | Rhodobacter sphaeroides
BGC0000645.3 |  | 0.52 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000656.5 |  | 0.51 | terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000648.3 |  | 0.49 | terpene | carotenoid | Myxococcus xanthus
BGC0000640.3 |  | 0.46 | terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000646.5 |  | 0.46 | terpene | β-carotein | uncultured bacterium
BGC0002561.3 |  | 0.45 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000641.3 |  | 0.45 | terpene | carotenoid | Enterobacteriaceae bacterium DC416
BGC0000639.3 |  | 0.45 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.45 | terpene | carotenoid | Enterobacteriaceae bacterium DC413

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none

Genes with terpene domains:
KC252_RS02790: PT_phytoene_like
Domain 1 (7 - 286): Prenyltransferase; Phytoene synthase like
Subtype: Diapophytoene synthase

Reactions:
  FPP → diapophytoene

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.67 out of 26.85
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.06 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.23 out of 26.06
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.07 out of 27.78
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.94 out of 18.46
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.34 out of 30.25
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.24 out of 30.25
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.86 out of 29.38
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.97 out of 20.97
Confidence: strong
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.94 out of 21.55
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.02 out of 21.55
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.02 out of 21.55
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.40 out of 21.55
Confidence: medium
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 22.40 out of 22.40
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.42 out of 28.19
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.51 out of 32.93
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.78 out of 32.93
Confidence: medium
Additional weak hits (13):
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 19.34 out of 29.51
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.85 out of 31.73
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.00 out of 30.98
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 19.65 out of 22.40
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.42 out of 32.93
Confidence: weak
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 25.23 out of 32.38
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.40 out of 20.01
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.55 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.87 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.50 out of 30.11
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.33 out of 35.63
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.38 out of 29.25
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.10 out of 33.14
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CRP | Cyclic AMP receptor protein
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
FuR variant 1 | Ferric Uptake Regulator
HypR | L-hydroxyproline utilization repressor
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
RutR | Regulator of the pyrimidine and purine metabolism
ZuR variant 1 | Zinc-responsive repressor

NZ_JAGSCE010000004.1 - Region 2 - opine-like-metallophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 110,266 - 132,378 nt. (total: 22,113 nt) Show pHMM detection rules used
opine-like-metallophore: (CntL and CntM)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
KC252_RS03275: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | opine-like-metallophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002487.3 |  | 0.96 | other (other) | staphylopine | Staphylococcus aureus subsp. aureus Mu50
BGC0002488.3 |  | 0.79 | other (other) | bacillopaline | Paenibacillus mucilaginosus KNP414
BGC0002490.2 |  | 0.59 | other (other) | yersinopine | Yersinia pestis CO92
BGC0002276.2 |  | 0.55 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0002489.2 |  | 0.52 | other (other) | pseudopaline | Pseudomonas aeruginosa PAO1
BGC0000888.5 |  | 0.49 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001928.2 |  | 0.48 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001184.4 |  | 0.44 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0002674.2 |  | 0.40 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0000519.4 |  | 0.40 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002487.3 |  | 0.96 | other (other) | staphylopine | Staphylococcus aureus subsp. aureus Mu50
BGC0002488.3 |  | 0.79 | other (other) | bacillopaline | Paenibacillus mucilaginosus KNP414
BGC0002490.2 |  | 0.59 | other (other) | yersinopine | Yersinia pestis CO92
BGC0002276.2 |  | 0.55 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0002489.2 |  | 0.52 | other (other) | pseudopaline | Pseudomonas aeruginosa PAO1
BGC0000888.5 |  | 0.49 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001928.2 |  | 0.48 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001184.4 |  | 0.44 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0002674.2 |  | 0.40 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0000519.4 |  | 0.40 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.19 out of 19.26
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.80 out of 18.16
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.03 out of 26.06
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.67 out of 27.78
Confidence: strong
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 27.24 out of 32.74
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.99 out of 32.93
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.26 out of 18.16
Confidence: strong
Additional weak hits (4):
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.47 out of 36.54
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.06 out of 29.38
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.65 out of 20.01
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 19.14 out of 22.40
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
AfsR | Pleiotropic regulatory for antibiotic production
CRP | Cyclic AMP receptor protein
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 2 | Ferric Uptake Regulator
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes

NZ_JAGSCE010000008.1 - Region 1 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 82,006 - 115,021 nt. (total: 33,016 nt) Show pHMM detection rules used
Region on contig edge.
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
KC252_RS06200: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

KC252_RS06205: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: kinase
KC252_RS06170: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000944.5 |  | 0.96 | other (non-nrp siderophore) | staphyloferrin A | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002682.2 |  | 0.56 | other (other) | aerobactin | Vibrio mimicus
BGC0000939.5 |  | 0.56 | other (other) | aerobactin | Grimontia hollisae
BGC0000947.5 |  | 0.54 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0002073.3 |  | 0.53 | NRPS | dehydroxynocardamine | Corynebacterium propinquum
BGC0001870.3 |  | 0.50 | other (other) | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0000943.5 |  | 0.50 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002683.2 |  | 0.46 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0002471.3 |  | 0.44 | other (other) | baumannoferrin A, baumannoferrin B | Acinetobacter baumannii AYE
BGC0001948.3 |  | 0.43 | other (other) | naseseazine C, C3-aryl pyrroloindolines | Streptomyces sp.

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000944.5 |  | 0.96 | other (non-nrp siderophore) | staphyloferrin A | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002682.2 |  | 0.56 | other (other) | aerobactin | Vibrio mimicus
BGC0000939.5 |  | 0.56 | other (other) | aerobactin | Grimontia hollisae
BGC0000947.5 |  | 0.54 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0002073.3 |  | 0.53 | NRPS | dehydroxynocardamine | Corynebacterium propinquum
BGC0001870.3 |  | 0.50 | other (other) | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0000943.5 |  | 0.50 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002683.2 |  | 0.46 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0002471.3 |  | 0.44 | other (other) | baumannoferrin A, baumannoferrin B | Acinetobacter baumannii AYE
BGC0001948.3 |  | 0.43 | other (other) | naseseazine C, C3-aryl pyrroloindolines | Streptomyces sp.

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.68 out of 29.38
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.22 out of 20.97
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.34 out of 20.97
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.07 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.42 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.42 out of 29.38
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.29 out of 24.78
Confidence: medium
Additional weak hits (2):
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.58 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.39 out of 30.11
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
FuR variant 1 | Ferric Uptake Regulator
LexA variant 2 | Repressor of DNA damage response