LOCUS       NZ_CP027059            23880 bp    DNA     circular CON 16-JUN-2024
DEFINITION  Paenibacillus konkukensis strain SK3146 chromosome.
ACCESSION   NZ_CP027059
VERSION     NZ_CP027059.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus konkukensis
  ORGANISM  Paenibacillus konkukensis
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 7969064)
  AUTHORS   Jung,H.I., Park,S., Niu,K.M., Lee,S.W., Kothari,D., Yi,K.J. and
            Kim,S.K.
  TITLE     Complete genome sequence of Paenibacillus konkukensis sp. nov.
            SK3146 as a potential probiotic strain
  JOURNAL   J Anim Sci Technol 63 (3), 666-670 (2021)
   PUBMED   34189514
REFERENCE   2  (bases 1 to 7969064)
  AUTHORS   Kim,S.-K., Jung,H.-I. and Lee,S.-W.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-FEB-2018) Department of Animal Science and Technology,
            Konkuk University, Neungdong-Ro, Seoul 140701, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 26-MAY-2016
            Assembly Method                   :: other v. HGAP
            Expected Final Version            :: yes
            Genome Coverage                   :: 7968964.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023523925.1-RS_2024_06_15
            Annotation Date                   :: 06/15/2024 05:36:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,013
            CDSs (total)                      :: 6,868
            Genes (coding)                    :: 6,761
            CDSs (with protein)               :: 6,761
            Genes (RNA)                       :: 145
            rRNAs                             :: 13, 12, 12 (5S, 16S, 23S)
            complete rRNAs                    :: 13, 12, 12 (5S, 16S, 23S)
            tRNAs                             :: 104
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 107
            CDSs (without protein)            :: 107
            Pseudo Genes (ambiguous residues) :: 0 of 107
            Pseudo Genes (frameshifted)       :: 45 of 107
            Pseudo Genes (incomplete)         :: 72 of 107
            Pseudo Genes (internal stop)      :: 13 of 107
            Pseudo Genes (multiple problems)  :: 20 of 107
            CRISPR Arrays                     :: 10
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:26:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5710439
            Orig. end                         :: 5734319
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP027059.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Soo-ki Kim.
            Genome not circularized.
            This genome has a base modification file available.
FEATURES             Location/Qualifiers
     region          1..23880
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="9"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..23880
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23880
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13880](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13880
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    142..158
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.7"
                     /tool="antismash"
     misc_feature    complement(203..219)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.12"
                     /tool="antismash"
     gene            complement(641..964)
                     /locus_tag="SK3146_RS24825"
                     /old_locus_tag="SK3146_04960"
     CDS             complement(641..964)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SK3146_RS24825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SK3146_04960"
                     /product="hypothetical protein"
                     /protein_id="WP_249861279.1"
                     /transl_table=11
                     /translation="MPPIKRLVCAALVVSALLLPTSAFASNGYNSSGHNNSYNNKNSNN
                     NSNSKINQSFNDFLSRIFGNKGHNEYHDYWGKEDEFRDWYEKNKDNCPPEESYDIWKKW
                     FCY"
     misc_feature    complement(951..964)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.86"
                     /tool="antismash"
     gene            complement(1102..3864)
                     /locus_tag="SK3146_RS24830"
                     /old_locus_tag="SK3146_04961"
     CDS             complement(1102..3864)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024627.4"
                     /locus_tag="SK3146_RS24830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SK3146_04961"
                     /product="right-handed parallel beta-helix
                     repeat-containing protein"
                     /protein_id="WP_249861280.1"
                     /transl_table=11
                     /translation="MQGKLKKLKTDDNEYIYPITVSDAVYVDPNTNLKTLLGQLQAGMG
                     SPVSYLIQAESWGIRNDGTEPEATTKGINDALAWAKEKGYNHVLLPGGTYSVQIDSNGT
                     AISMPGGMHLELHADCVLQLQANSSPSYRIIEVKGVRHAKISGGTLIGDKQNHWFEIFV
                     KFTRGGVNADGSLNDDPNFIRSEVIDRYANPGLLSNFRLWSIDGIAATSYSFYQYKDTV
                     SKDTFVNLRNNGGFAPAAPTGRGWFDTIDNANKMVFVIDISSSPLTDEQIAQISAKIDN
                     SYYTHESGLGIGILSSNYVEVSGVEIANCTGDGILTGIGVYYDDPSQYSQEQIGQHIYI
                     HDCTIHHCRRQGMSLCGPNDVYVMNNTIHHIGYADDGTTSDFRNGIPPMFGIDIESMVG
                     ESNIPFKSIYLNQTSGLETNYRIYIYNNYIHHNARGHFVNADGTYITLQNNTFEGYTVG
                     GVSSYQNQWYVKYINNTFIGGSLTVSGNNFVNGAVLNKAHLNLSNVQGAFVDNCQIKDG
                     LFYGSSIYGYFGMPAAVDVTTGTFTYNTPHGMGNGAQISFEQWFGKVPSGISVDKLYYT
                     VNVTSISFQVSETKGGKPVTITDAGTSGFNISRYNYGRCYISNITVEKDWRDNNNYDGS
                     TGFIPLVAGAALKNITVKNCDVSIKPPDNYVGRPNTIDGLTIIEGTGNLQSSHISNLKA
                     MRAKTGAMGGDITLGTNNVYSKVNLDGALFQGVQVNFGAANLSNGTFLNAKIYKPDSPN
                     TAAITKSYMENTAINLHWLTYDGAMTIAECLFNNVTMDASAAVRLLGNLDINSGLTDNR
                     MNAVPVSGKYALGQIIYNASPAPGGYVGWICTTAGYASNLSWSAGKAYSKGSRIVAAGH
                     VYEAQNNGTSGSAVPAFPTASGGTITDNDMMWKEIGLLAVFKPFGLIGT"
     gene            complement(3909..4763)
                     /locus_tag="SK3146_RS24835"
                     /old_locus_tag="SK3146_04962"
     CDS             complement(3909..4763)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012271.4"
                     /locus_tag="SK3146_RS24835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SK3146_04962"
                     /product="fibronectin type III domain-containing protein"
                     /protein_id="WP_249861281.1"
                     /transl_table=11
                     /translation="MAGENDSPADNSVYYEDWAGGEGVTVINTVPPNEVTQLIVADVRA
                     TRVTLSWTASTSPTIAAYDIYNGSAPVGTTAATTYTVDGLSPQTAYTFTVRAKSQDGLS
                     SSGVSVMVTTLAQTYALSMNGVNEYILTSPLSFDTVIMDMNASPKAGGYSAYLDASRGI
                     ALTTFGRDSSGRDFLQSGWKSVMVDGIDKTSLVGTTTVLPSGQRTVVVLSLVSPGKAPV
                     ALFSNQLGAIPMKGLLYSVQFLLNGHVIAYYDFTKPFTGPDVPDRSGNNQTAKLQGGTW
                     VSN"
     misc_feature    4741..4755
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.06"
                     /tool="antismash"
     gene            5299..6060
                     /locus_tag="SK3146_RS24840"
                     /old_locus_tag="SK3146_04964"
     CDS             5299..6060
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0009103 - lipopolysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1216: exopolysaccharide biosynthesis domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014732.4"
                     /locus_tag="SK3146_RS24840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SK3146_04964"
                     /product="Wzz/FepE/Etk N-terminal domain-containing
                     protein"
                     /protein_id="WP_259618081.1"
                     /transl_table=11
                     /translation="MEINLKEYIMMIKKRLWIVVLFVLASTMLTAFYSTVNYQPVYMAA
                     TKLIVNKTSEKDMTGKEQIDYAAIGVNIALINTYKEIIKTPAIMDKVVQRYPDLNLSAE
                     QLIAMTNVSDLHETQVMTIVAQSGSYEKAVKIANAVSDVFQTEIPKIMKVDNVTILNRA
                     KMQDNPVPINKKSNQYIVLSFAASLVISIGIIFLLEALDDTVKTEDDVREMFGASTLAL
                     IPKLKDKEINAGKRSKSRRKVGEVAHAKTIQ"
     gene            6041..6700
                     /locus_tag="SK3146_RS24845"
                     /old_locus_tag="SK3146_04965"
     CDS             6041..6700
                     /EC_number="2.7.10.2"
                     /GO_function="GO:0004713 - protein tyrosine kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0004715 - non-membrane spanning protein
                     tyrosine kinase activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1216: exopolysaccharide biosynthesis domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR01007.1"
                     /locus_tag="SK3146_RS24845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SK3146_04965"
                     /product="CpsD/CapB family tyrosine-protein kinase"
                     /protein_id="WP_249861283.1"
                     /transl_table=11
                     /translation="MPKPSNSEIIMEQNPSSAASEAYRSLRFNVEASAFDDGIKTVTIT
                     SAARGEGKSTTALNLAFAYAQIGKKVVLVDADMRQPSLHRTLGEEGSRGLSGYLSAYCS
                     MNEIVQETHVKNLSVITAGAVPPSPADLLASHEMVLLLEALKRNYDMVFIDTPPVLSLT
                     DAKIMASQCDGVLLVVEYGKVKRNVAKKVKEELALAKAKLLGIVMNKISGQAAEAY"
     misc_feature    complement(6734..6749)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 25.68"
                     /tool="antismash"
     gene            6774..8081
                     /locus_tag="SK3146_RS24850"
                     /old_locus_tag="SK3146_04966"
     CDS             6774..8081
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1029: RND family
                     efflux transporter MFP subunit"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF027890.4"
                     /locus_tag="SK3146_RS24850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SK3146_04966"
                     /product="efflux RND transporter periplasmic adaptor
                     subunit"
                     /protein_id="WP_249861284.1"
                     /transl_table=11
                     /translation="MRRKRHRLVRRRVKTVAVLALSFAIIAGCSETIPLEHNAAGAGSG
                     QEQSQSQQPLKNVKVMKVAKQKIGDPLVHAGDVQSSVQYDIAAKASGDVEAILKARGDM
                     VQEGEVIIRLNSTDAQFQKEKAALAVQTVQDAIAKAKERAKKDMDNQKRELANSIQKSE
                     QNLVDLTKTYNKTKNDYEVGLATKLQVYQMEVQLRNARMDLEQLKQKSDMLEPIDATSE
                     LETQLKGAQMTQLQVEQSMSYLEVKAPASGILTEMPLETGMSLQQGAKIGVIQKLDPIK
                     IKAQLKEEEYKYVTGKSELTYYLQGAAQKNKGKISFLAKVIDPDTKAYEINVDVPNQNM
                     ELKPGMKVWLQLTEDQDQIVVAVPTYSIVKEGDDNYVFVLNGDTVEKRKVQLGRLNDSI
                     QEITSGVNEGEQVVVEGMNQLNDKEKVKSAAVEQQK"
     gene            8099..9808
                     /locus_tag="SK3146_RS24855"
                     /old_locus_tag="SK3146_04967"
     CDS             8099..9808
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SK3146_RS24855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SK3146_04967"
                     /product="hypothetical protein"
                     /protein_id="WP_249861285.1"
                     /transl_table=11
                     /translation="MITKWKRILVVFALLVSLLIPPMPPLATAQEGAPAPADYYVTETV
                     KASVKNILNEQAPEGVRIAAVVRLYNEGSRLTRVPDYEVRAKTDGGIEYTLRPSAANAI
                     AIQPKETVELTYMIVVDREDAFSVSQISWVDVDEFVSPRKETTMLSIPVSSIEWRGDLG
                     AFSDPSVNKQWGEAFTIAELSPVIEYKPISLIEQNTPQGPKSILTLLAENKGDKKKTIP
                     DFLINGKAEQKVFTGKRLEQDAVALEPNEQKYIHYAIPAGKKEEMKSLTVLTPESFAVD
                     DKTKIDYSIGRFSIALPDGNAAAASVEQSEPYEMNQWIRFDPLNRVIQPEIGVALVDLH
                     IHDSVGGGFKAAVAKFKLQNRSDRPMPVPKFQAQLVSAAGNQYTGNRQTTVVETLAPNI
                     SYVIYYTFVLPTTEKGERLTMEILDGDSVAPYNIPIARLKTKAQSDQSDGDIQFYPFTV
                     KFNSWKEEVFYGSAKSSLPYSYKLTLDLDVKLQDQSVVDQSFPKLKVELVDASGNVIGS
                     KALPFTGDNRVASGIQTFSMDSTLFEFSNTLRVYETVDTPFGEADRLVATLQ"
     gene            10001..11941
                     /locus_tag="SK3146_RS24860"
                     /old_locus_tag="SK3146_04968"
     CDS             10001..11941
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001274517.1"
                     /locus_tag="SK3146_RS24860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SK3146_04968"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_249861286.1"
                     /sec_met_domain="GATase_7 (E-value: 1.6e-19, bitscore:
                     68.7, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 3.5e-23, bitscore:
                     81.5, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAIAGIYHLDNEPVLAEHGRTMMRELEKYPADAIRTWNSGAVFL
                     GCHVQHITPEAVYEQLPYYDADRQIVIAADAILDNRPELVRLLEVDYERRRKITDSELI
                     LLAYERWGQEAPQHLIGDFAFMLWDAKARQLFGARDFSGSRTLYYCRSGMRFAFCTVIG
                     PLLSLPRMKAELNESWLAEYLAISGMIDVVDTAATVYKDIEQLPPAHSITVTSSGARLS
                     RYCTLTPGKPLRLKSDGEYVEAFQAVFGEAVTSRLRTHRQVGAQLSGGLDSGSIAGFAA
                     GALRKENKPLHTFSYVPSGDFHDYTSKRYMANERPFIEATVRHVGNIRDHYLDFEGRNS
                     FLEVEDFLDLMEMPYKFFENSFWLKGIFEKARDEQVGVLLNGGRGNLSISWGSANEYYA
                     ILLKRLKWVKLFKELDQYSTKTGGSRYRRLPLIARTAFPFIDRMVPQADAYPFPPLIHP
                     EFARRTGVFKKLQRFDIDESGWYGGIDAYEMRKRHFEELFHWNASNTLAAKLSLRYGLW
                     KRDPTNDLRVIRFCLSVPEEQYVQGGMDRALIRRATENVLPDQVRLNQKVRGVQGADWV
                     HRMIPHWNAFREELHRLCADERMRQILNVPAIEKALHKLREGVRPEHAIDPDYKVLMRS
                     LIVYRFISRLT"
     gene            11959..12099
                     /locus_tag="SK3146_RS24865"
                     /old_locus_tag="SK3146_04969"
     CDS             11959..12099
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017378581.1"
                     /locus_tag="SK3146_RS24865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SK3146_04969"
                     /product="paeninodin family lasso peptide"
                     /protein_id="WP_249861287.1"
                     /transl_table=11
                     /translation="MVKKEWQQPKLEVLDVKQTMASTHNGPLTDEAYIPGRNSDDPRFT
                     S"
     misc_feature    complement(11962..11977)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.66"
                     /tool="antismash"
     gene            12202..13131
                     /locus_tag="SK3146_RS24870"
                     /old_locus_tag="SK3146_04970"
     CDS             12202..13131
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000582033.1"
                     /locus_tag="SK3146_RS24870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SK3146_04970"
                     /product="aldolase"
                     /protein_id="WP_249861288.1"
                     /transl_table=11
                     /translation="MIQTENKVVYKAFDLSIASGMELPELPVIHRSTGRADVEIIVDPA
                     ARFGAGLESRPYYHDVRNGEVTFHVPGNANYSIREGRVITVAPLPSADEGLTRLYVLGT
                     CMGALLMQRRKYPLHGSAVAIGGKAYAIVGESGAGKSTLASAFIQAGYTLVSDDLISVS
                     LSPVDETAVITPSFPQQKLWRESLEQFGMETGTYRSIYGRETKYSVPVATHYCAQPLPL
                     GGVIELVKTEEPEVSIHPISKLDRLQTLFRHTFRHFLIPRLGLMEWHFQTSAAIAGQAA
                     MFQLRRPAGGFTAPQLVSLLLENLRMEE"
     gene            13135..13425
                     /locus_tag="SK3146_RS24875"
                     /old_locus_tag="SK3146_04971"
     CDS             13135..13425
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000594720.1"
                     /locus_tag="SK3146_RS24875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SK3146_04971"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_249861289.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.2e-27,
                     bitscore: 93.5, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 7e-18, bitscore: 63.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPNQSIALTDRFVQGAGNIVSDMDGEKVMLSIHNSKYYNLGEVG
                     GDIWEQLAQPAEVERIVDSLMRQYEVERDDCEHQVVSFLQHLLEEGLIQWA"
     aSDomain        13183..13416
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_SK3146_RS24875_Stand_Alone_Lasso_RRE.
                     1"
                     /evalue="9.20E-30"
                     /identifier="RREFam002.1"
                     /label="SK3146_RS24875"
                     /locus_tag="SK3146_RS24875"
                     /protein_end="94"
                     /protein_start="16"
                     /score="93.5"
                     /tool="antismash"
                     /translation="AGNIVSDMDGEKVMLSIHNSKYYNLGEVGGDIWEQLAQPAEVERI
                     VDSLMRQYEVERDDCEHQVVSFLQHLLEEGLIQ"
     gene            13416..13880
                     /locus_tag="SK3146_RS24880"
                     /old_locus_tag="SK3146_04972"
     CDS             13416..13880
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012261438.1"
                     /locus_tag="SK3146_RS24880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SK3146_04972"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_249861290.1"
                     /sec_met_domain="PF13471 (E-value: 8.6e-25, bitscore: 85.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVIRKARNWLSLDWKTMLAFIEAYVYLGWARFLVSRPFAEITPS
                     LGEAMEETPETSLPEQEGRLRVVYDAVQIMSRHTFWESKCLVRAIAALKMLERRRIEST
                     LYLGTAKDEAGKLIAHAWLRSGPYYITGAEEMGRFRVVGKFAKRISDKGK"
     gene            13910..15082
                     /locus_tag="SK3146_RS24885"
                     /old_locus_tag="SK3146_04973"
     CDS             13910..15082
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016105869.1"
                     /locus_tag="SK3146_RS24885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SK3146_04973"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_249861291.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 1.4e-64, bitscore:
                     216.6, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTASFPEELNLMLALLGGEAGDKLQAAGIDWDLFLQLARHHRVY
                     PSLYHKLQQAGISAIPAHVMQALRADYQQNIFRMLQLSGEMEQICRTLGEANIRTLVLK
                     GPVLAADLYGDLSLRTCGDLDLLVPIDDLDRAEQLLGLLGYIKDEYIQTVLSDWKWRHH
                     HITFFHRHMGIKIELHWRLGPGPGSEPGFYSLWQRKRLSAITRHPVYYLGREDLFLFLV
                     SHGARHGWSRLRWLTDIHQLCRQPLDDNKLRGLLVKYRTSHIAAQAWILTSQLLHTPLS
                     ESCRRWSKEQRARSLAQGALYYIGQMINLHSEPLPEDVSRYHKRHLFALMSCQTKLLFI
                     MSLLYPYPHDAETLALPKALHFLYFPLRPFLWAWRKTKKVRLIVARSGIK"
     gene            15079..16911
                     /locus_tag="SK3146_RS24890"
                     /old_locus_tag="SK3146_04974"
     CDS             15079..16911
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016096316.1"
                     /locus_tag="SK3146_RS24890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SK3146_04974"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_249861292.1"
                     /transl_table=11
                     /translation="MKQVLYFARKMHAYAGNILFVNLLGMTLVGFLDGIGMFLLIPLLS
                     LIGILQINAGSIPLAGGLDLLKELPGPLSLLIVLAIYAALVIGQALIQRNLSLRDIRIH
                     TGFINHVRMETYRSLLQADWDFFIKRRKSDFIHAMTDELGRVTNGTYVFLQFAASLVFT
                     LIQIAIAFWLSAKLTLFVIGCGLLLAFFSRVLIRRSRTLGGQTSELARSYIAGITDHFN
                     GIKDIKSNMLEESRNRWLAEWCERIGEERYGHAKLRSDSQLYYKAASALIIAAFVYLSS
                     YLFHTQGGQLLLIMMIFSRLWPRFTGIQSNLEQIASALPAFASLLQLQEQCRASREIRD
                     GELAPEDVAPLAVERGLECRGVSFRYNRQEPVRALERIDLYIPAMRMTAVIGRSGAGKS
                     TLIDMLMGLLRPEEGQVLVDGVPLGGRLLQRLRKAVGYVPQDPLLFGGSIRENLLLIDP
                     EASERQLWEALEFAAADEFVRRLPQGLDTLIGDRGVRLSGGERQRLVLARAILRRPSIL
                     VLDEATSALDAENEARIQEALERLKGKMTIVVIAHRLSTIRNADQVVVLDQGRIVQQGG
                     FTQLSKERGKLFAHLLRNQMMPDAENNDLEQLPV"
     gene            16932..17972
                     /locus_tag="SK3146_RS24895"
                     /old_locus_tag="SK3146_04975"
     CDS             16932..17972
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123: polyprenol-monophosphomannose synthase ppm1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001081477.1"
                     /locus_tag="SK3146_RS24895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SK3146_04975"
                     /product="glycosyltransferase"
                     /protein_id="WP_249861293.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 4.2e-35,
                     bitscore: 119.8, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAKVSVIIPVYNAERYLAECIESLMKQSLQECEFLFIDDGSTDR
                     SAGLIETYAGQDRRIQLIRQDNQGVSAARNTGLRVASGEYVGFVDADDYIEPDMMAVLY
                     EAAGQYAGDVVISNFESEIEGHWVQTSYPFLTNRLLDREFVRKEILPYFLRSDQLNSVW
                     NKLYRNQLIQDCGAAFPDKVALGEDGIFNMRVFCHASNAVYLDYCGYHYREVDGSATRN
                     IIGKDYFQRALEVYLTDVPEMKAIPLSREEIRKLKAVRLVHSVMSYVYLYFQAAQKVSF
                     KARFAYVSRMIANPHVQEALAFYADEKAGKLGRYDRWLLEAIRGRSAISLYCITSYSKL
                     RSAANK"
     gene            18020..19186
                     /locus_tag="SK3146_RS24900"
                     /old_locus_tag="SK3146_04976"
     CDS             18020..19186
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016132437.1"
                     /locus_tag="SK3146_RS24900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SK3146_04976"
                     /product="polysaccharide pyruvyl transferase family
                     protein"
                     /protein_id="WP_249861294.1"
                     /transl_table=11
                     /translation="MKIMMFAHGGSLNRGCEAIVRSSTSLIKERIRDAKVYLASGKPDT
                     DQIITKLDGIYDGSARGIRKYSYDWFVSAVKMKLFQDETYALGKIHDNIVRHIPGMDVC
                     LSIGGDNYCYGEQPGWYEINRRVKASGKKLVLWGCSIGEEDMSEKKLEDLKRFDLILAR
                     ETLTYNMLVQKGLTNVQLCADPAFTMEKEELELPSGWQDGNTVGLNFSPLVWKRNVQSQ
                     QAVRELISHILTTTDMTIALTPHVMEGGNNDYEMLRQYYEEFRATDRVILLPGDLNAVQ
                     YKGYISRMRFFVGARTHATIAAYSNFVPTMVLGYSIKSKGISKDIFGEEKLVLGIKEIS
                     DGVLLKAKFDEMIREERELRQRLQTSIPHIKKMSYKAVEHLGKLVQSR"
     misc_feature    complement(18033..18048)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.08"
                     /tool="antismash"
     gene            19195..20388
                     /locus_tag="SK3146_RS24905"
                     /old_locus_tag="SK3146_04977"
     CDS             19195..20388
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016131139.1"
                     /locus_tag="SK3146_RS24905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SK3146_04977"
                     /product="glycosyltransferase"
                     /protein_id="WP_249861295.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 5.8e-33,
                     bitscore: 112.6, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKNLLFIMPSLMSGGGEKSLVTLLNQIDFQQYNVDLFLLDHNGL
                     FMELIPEKVELLPLTGVYHEFRLPMLKAFRKLLRQGYIALAFHRIAFTLSNRGKRNISQ
                     REQYSWRHMASFLDRLPKTYDAAIGFMEKTSIYFCVDKVNAHQKIGWVHTDYDQMGMDS
                     RFDHHYYKQLDRIVTVSEECANVLKRRFPDQQHKVEVIYNIVSPESIISLANQSKTDVY
                     QKNKDETIIVSVGRLHDQKGFDMAIESCRKLVDRGYRIKWNIIGEGEERGRLEHLIQEY
                     DLCDYVRLLGLRSNPYPYIKQADIYAQTSKFEGKSIAIDEAKILNKPILVTNFSTARDQ
                     ISDGVDGLIVDMNAEAIAEGIEILINDKQLRTRLIYNLSRTALGTEGEIEKFYQLLT"
     gene            20439..21683
                     /locus_tag="SK3146_RS24910"
                     /old_locus_tag="SK3146_04978"
     CDS             20439..21683
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018781209.1"
                     /locus_tag="SK3146_RS24910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SK3146_04978"
                     /product="glycosyltransferase"
                     /protein_id="WP_249861296.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.8e-26,
                     bitscore: 91.4, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQKILFVMNNLQCGGAEKALISLLETIDYSLYEVDLYLLRHSGI
                     FMSKIPAAVKLLGEPQEYQYYDMPIRKAVLNCLKRGRINIASFRLRAGVIYKTEKNSVR
                     CEQRVWKYLSKSLKSIDQVYDIAIGYLEKNPIYFCIDKVKARKKIGFIHNDYDRLGMDP
                     SYDKTYFDKLDHLVTVSGECGTILKKRFPKYAHKVEVMHNIVSPAAIRNLAMEDADWNA
                     ANTIPDSPVGQTPPIKKDSAIKLVSIGRLNYQKGFEMAVQTCKELVEGGYPVQWYVIGE
                     GEERKTLERMISENGLQDRFHLLGVKENPYPYIREADIYVQPSRFEGKSIAIDEAKILH
                     KPIVVTNFSTAKDQITDRHNGLIVEMDARSIAQGIKALLEDASLRRQLSVNLEKEPLGT
                     ETEIEKLYALFDSKK"
     gene            21707..22888
                     /locus_tag="SK3146_RS24915"
                     /old_locus_tag="SK3146_04979"
     CDS             21707..22888
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003202152.1"
                     /locus_tag="SK3146_RS24915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SK3146_04979"
                     /product="glycoside hydrolase family 88 protein"
                     /protein_id="WP_249861297.1"
                     /transl_table=11
                     /translation="MIALIVCLLLFALIIVVILIDIVPIFKDWLSRIHIGRFQDKQLWS
                     RSITNVGIQWLNHTPQIKVTDNTRLVAIDMLKGNYSKNSIQHWQEASLLMGLAEYVKRS
                     GDQEVKREIEKFLASKFDRDGEWVEKPEQVDAAILAYAVMKLDFINTDHYKKALETTWE
                     LIRDHLGTDGTVAYRKFMPNYRYVDTIGFICPFLVCYGLRYRQEACVDLAVKQILSYEK
                     HGMLEGHHIPSHAYQIDNKLPLGLYGWGRGLGWFAIGLVDAWNELPAGHKAKKTLENSV
                     RKFAVAAMAFQQADGNWSWTVTRQECRADSSTTATLGWFMQQASRIEDISADCLESAER
                     AVRYLMKATRRNGAVDFSQGDTKDIGVYSMLFNILPFTQGFCIRLMNSIHVGP"
     gene            22905..23465
                     /locus_tag="SK3146_RS24920"
                     /old_locus_tag="SK3146_04980"
     CDS             22905..23465
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0120225 - coenzyme A binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156: Chloramphenicol acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016132434.1"
                     /locus_tag="SK3146_RS24920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SK3146_04980"
                     /product="acyltransferase"
                     /protein_id="WP_249861298.1"
                     /transl_table=11
                     /translation="MLKKIICFLRARIRKCLLEELWLEDYIRMGMRVGQNCSIQPGVVF
                     DYSHCWLIRIGDNVTIAPYAYLLTHDASTKQLNQYTKVGSITVEDDVFIGARALIMPGV
                     TLGRGCIVAAGSIVTKSVPPEVIVGGAPAKFICTVEEYARKNNELLEKKTVYDRDFTIG
                     GRISAEKKRKMYEELINDIGYVV"
     misc_feature    22923..22932
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
ORIGIN
        1 cagccaaaac ctttgccgat ctgaaagggc attgggcgca aaaggacgcc gagctgctgg
       61 catccaaagg attggtcaac ggcatgacgg caacgacgtt tgctccggat aaccggatca
      121 cgcgtgcgga attcgccgcg ctgctggtaa gagcggcagg attgacaccg cagacgtcgt
      181 cttcattctc cgatgtcaaa gcttccgact ggtacgcagg cgctgtcggc gcggctgcca
      241 aggcgggatt gatcgacggc ttcgagaacg gaacgttcca gccgaacgca acgattaccc
      301 gtgaacaaat ggccgtcatg atcgaccgga ccctcaagtt cacaggcaaa caaggcaata
      361 cgaataccgg caagcttgcc gcattcaaag acagctccac catctcgagc tgggctcaag
      421 atgccgcagc aggagcggtc aatgccggaa tcattaacgg cttgaccgac accgaattcg
      481 cgcctcgcga gcaggcttcc cgcgcagaag cggccgttat gctcaagcgg ctgctgcaat
      541 acgcggagct gatgaactaa ccggatcgcc ttacgagcga ataaccggat gaacaaaaaa
      601 gagtctatcc cccgagaaag agggatagac tcttttgttc ttaataacag aaccatttct
      661 tccaaatgtc atacgattcc tcaggggggc agttgtcctt atttttctcg taccagtccc
      721 ggaattcatc ttcttttccc caataatcat ggtattcgtt atgccctttg ttgccgaaga
      781 tacgggataa gaaatcgttg aacgactgat tgatcttgct gttgctgtta ttattgctgt
      841 tcttgttgtt gtaactgttg ttatggccgc tggagttgta accgtttgaa gcgaaggcgg
      901 aagtcggcag taacagcgcg cttacgacta gagctgcgca tactaatctt ttgataggcg
      961 gcaaggtgcg aaagtcctcc tttgttatgg gatttaagta ggaaaaaagt tcgttataaa
     1021 gaatatacct cataatgaac attttgagaa cgaaaaattt gccgcttaag aaaatatagc
     1081 gattcctatt cgataagcgc tttacgtgcc gataagtcca aacggtttaa atacggccag
     1141 caatccgatt tctttccaca tcatatcgtt atccgtgatc gtaccgcccg aggcggttgg
     1201 aaatgcaggg accgcggagc cggacgttcc gttattttgg gcttcataca catgccctgc
     1261 cgcaacaatc cggcttcctt tcgaataagc cttgcccgcc gaccatgaca aattgctcgc
     1321 atatccggcc gtcgtgcaaa tccaacccac atatccgccc ggagcggggg aggcgttata
     1381 gatgatttgg cccagagcgt atttaccgct caccggcacg gcgttcatcc gattatcggt
     1441 caagcccgag ttgatatcga gattgcccag caggcggacg gcggcgctcg catccatcgt
     1501 tacgttgttg aacaagcatt cggcaatcgt catcgcccca tcgtatgtga gccagtggag
     1561 attgatcgcc gtattttcca tatagctctt tgtaatggcc gctgtgtttg gactgtccgg
     1621 tttataaatt ttggcgttaa ggaaggtgcc attgctcaaa ttagcggccc cgaaattgac
     1681 ctgtacgcct tggaatagcg cgccgtcaag gttaaccttg gaataaacgt tattggtgcc
     1741 gagcgtaatg tctccgccca tagcgcctgt cttggctcgc atcgctttga gattgctgat
     1801 gtggctgctt tgcaaatttc ccgtgccttc aataatggtg agtccgtcga ttgtgttggg
     1861 tcttccgaca tagttatccg gcggcttaat ggagacgtcg cagtttttga ccgtaatgtt
     1921 ttttaacgca gcgccggcaa caagggggat aaaccccgtg cttccgtcgt agttgttatt
     1981 gtctctccag tccttttcta ccgttatatt ggaaatgtaa cagcgaccgt agttgtaacg
     2041 ggatatgtta aagccgcttg ttcctgcgtc cgtaatggta actggctttc ctcccttggt
     2101 ctccgatact tgaaagctaa tgctggttac attgaccgta tagtacaatt tatcgacgct
     2161 gatgcctgag ggcaccttac cgaaccattg ctcgaagctg atttgggctc cgttgcccat
     2221 gccgtgagga gtgttgtagg taaatgtacc cgttgtgacg tcgaccgcag ccggcatgcc
     2281 gaagtagccg tatatgctgg agccgtagaa cagcccgtct ttaatctggc agttgtcgac
     2341 aaaagccccc tggacattgg acaaattcaa atgtgctttg ttcagcacag ctccgttcac
     2401 gaaattattg ccggatacgg tgagagagcc gccgataaac gtgttgttga tatatttgac
     2461 ataccactgg ttttggtaag agctgacgcc tccgactgta tagccttcga acgtattgtt
     2521 ctgcagcgta atgtaagtac cgtcagcatt gacgaaatgg ccgcgtgcgt tgtgatgaat
     2581 ataattattg tatatataaa ttcggtagtt cgtttcgagc ccggaagttt ggttcagata
     2641 gatgcttttg aacggaatat tgctttctcc gaccatcgat tcgatatcga tcccgaacat
     2701 cggaggtatg ccgttacgaa agtcgctggt cgtcccgtcg tcggcatagc cgatatgatg
     2761 gatcgtattg ttcatgacgt agacgtcgtt aggtccgcac agggacattc cctgtctgcg
     2821 gcaatgatgg atcgtgcagt cgtgaatata aatatgctgc cctatctgtt cctggctata
     2881 ttgggacgga tcgtcgtaat agaccccgat gcccgtcaaa atgccgtcgc cggtgcaatt
     2941 ggcaatctcg acgccgctta cttccacata gttagaactc agaataccga tacctaagcc
     3001 gctttcatgc gtgtagtagg agttatcgat tttggcgctg atttgtgcaa tctgctcgtc
     3061 ggttaacggg gaagaggaaa tatcgataac gaacaccatc ttgttcgcgt tatcgatcgt
     3121 atcgaaccac ccccgcccgg tcggcgcggc aggcgcgaat ccgccgttat tgcggagatt
     3181 gacgaacgta tccttggaca ccgtatcttt gtattgataa aagctgtacg aggttgcggc
     3241 gatgccgtca atcgaccata aacggaagtt ggacagaagt cccggattgg cataacgatc
     3301 aatcacttcg ctgcgaatga aattcggatc gtcgttcagc gagccgtccg cattgacgcc
     3361 gccgcgcgta aatttgacaa agatttcgaa ccaatggttc tgcttgtcgc cgatcagcgt
     3421 tccgccggaa attttggcgt gccggactcc tttgacttca attatgcggt agcttggcga
     3481 ggaattggcc tgcagctgca gaacgcaatc tgcgtgcagc tccagatgca tgccgcccgg
     3541 catggagatg gcggttccat tcgaatcgat ctgcacgctg tatgtccctc cgggcagcag
     3601 gacatgattg tatcctttct ccttagccca cgctaatgca tcgttaattc ctttggtcgt
     3661 agcttcgggt tcggtcccgt cattgcgaat gccccaagac tccgcctgga tgagataaga
     3721 aacaggggag cccatgcctg cttgcaactg cccgagcagc gttttcagat tcgtgttcgg
     3781 gtcgacatac acggcatcgg acaccgtaat cggatatata tattcgttgt cgtcggtttt
     3841 taattttttc agcttgccct gcataggttg cacctcctaa attaaaaatg gattgcgcaa
     3901 gcggcgcgct aattgctcac ccatgtgcct ccttgcagct tggccgtctg attgttgccg
     3961 cttcgatccg gaacgtccgg cccggtgaac ggtttggtga aatcatagta agcaatcaca
     4021 tgtccattca acaaaaattg cacgctatac agcagccctt tcatgggaat ggctccgagc
     4081 tggttggaga atagagcgac gggggccttt ccgggagaaa caagagatag aacaaccacg
     4141 gtgcgctgtc cgctcgggag cacggtggtt gtaccgacca agcttgtttt atctattccg
     4201 tcgaccatca cggatttcca gccggactgc aggaaatccc ggcccgagct gtctctgccg
     4261 aaggtcgtta gcgcaatgcc tctggaagcg tcgaggtagg cggaataacc tcccgctttc
     4321 ggagatgcgt tcatatccat aatgacggta tcgaacgaca gcggtgaagt cagaatatat
     4381 tcgttgacgc cgttcattga caaggcgtag gtttgcgcca aagttgtaac cataacgctg
     4441 acaccgctgg aactaagacc gtcttgactt ttggctctaa ccgtgaaggt atatgcggtt
     4501 tgcgggctta ggccgtctac cgtatacgtc gtggcggctg ttgtccctac cggggccgag
     4561 ccgttgtaaa tgtcataagc cgcgatagtc ggcgatgtgc tcgctgtcca ggataaagta
     4621 acccgggtag ctcgtacatc cgctacgatc agctgagtca cttcgttcgg aggaacggtg
     4681 ttgatgacgg taacgccttc tcctcccgcc caatcttcgt aataaacgga attgtctgct
     4741 ggactgtcat tttcaccagc catggacatc acctctttat ttaatgtcgt aaaaccggag
     4801 acagaatcac agaggatagg gggatgcgaa atgcagcccc ctaagctagc ggcccaaccg
     4861 ccgttaggcg atgcttcaag gaagatctca aacctccccc tagtcgatag agtgtttatt
     4921 gccataaagg aaaatataag ttatcggggg tcccgccaag aatcaattca aatagcaccg
     4981 gacacgcagg ttcatgcatc gtggaaaggc aacgaatata agctgttctc aaagtataat
     5041 atgtcccaaa aattggaatt gtgaataggc atttcattca tcattgtatg ctaaagagaa
     5101 cgaaggcagc gttcgacggt aagtttcaag acggtgattt taattctgtg aaatttgata
     5161 caaaatggat caaaccctag gaaaacgctg ttgacatgat acaaaaagtg tcataaagta
     5221 gtatctatag ccaatgatac aaaaggtatc aatgaagccg ggagttagct gaaagaatac
     5281 ttcctacgga ggagaagcat ggagattaat ttaaaagagt atatcatgat gataaaaaag
     5341 cggctgtgga ttgtcgtact attcgtactt gcctccacga tgttgaccgc cttctacagc
     5401 accgtcaact atcagcccgt ctatatggcc gcaaccaaat tgatcgttaa caaaacgagc
     5461 gaaaaggaca tgacgggcaa ggagcaaatc gattatgcgg cgatcggcgt caatattgct
     5521 ctcatcaata catataagga aattattaaa acccccgcca ttatggataa agtcgtgcag
     5581 cgctatcccg acctgaactt gtccgcagaa caactcatcg ctatgaccaa cgtatccgat
     5641 ttgcatgaaa cccaggttat gacgatcgtt gcccagagcg gctcctatga aaaagcggtc
     5701 aaaattgcca atgccgtctc cgatgtgttc cagacggaaa ttcccaaaat tatgaaggtc
     5761 gataacgtaa cgatattaaa tcgggccaag atgcaagaca accccgtccc cattaacaaa
     5821 aaatcgaacc aatacatcgt attaagcttc gctgcctcgc tggtcatttc tatcggaatc
     5881 atctttttat tagaagcttt ggacgatacg gtcaagacgg aggacgatgt gcgcgaaatg
     5941 ttcggagcgt cgactctggc tctgattccc aaattgaagg ataaagagat aaatgcgggc
     6001 aaacgaagca agtcccgaag gaaggtaggt gaggttgcac atgccaaaac catccaatag
     6061 cgagattata atggagcaaa atccaagttc ggccgcctcg gaagcatacc gttcgttacg
     6121 gttcaatgtc gaggcatcgg ccttcgatga cggaatcaag accgtgacga ttacttccgc
     6181 cgcaagaggc gagggcaaat cgacgacggc gctcaatctg gctttcgctt atgctcagat
     6241 cggcaagaag gtcgtgctgg tcgatgcgga tatgcgccag ccttccctgc accgcacatt
     6301 gggcgaggag ggaagcaggg ggttgtcggg ttatttatcc gcctattgtt ccatgaatga
     6361 gattgtgcag gagactcatg tcaagaactt gtccgttatc acggcaggcg ccgttccgcc
     6421 gagtcccgcc gatctgctcg catcccatga gatggtcctg ctgctggaag cgctgaagag
     6481 aaactacgat atggtattta tcgatacgcc tccggtactt tccttaacgg acgcgaaaat
     6541 tatggcttcg caatgcgacg gcgtgctgct ggtcgtggaa tacggcaaag tgaaacgaaa
     6601 tgtagcgaag aaggtgaagg aagaactggc actagccaaa gcaaagctgc tcgggatcgt
     6661 catgaacaaa attagcggcc aggctgcgga agcgtactga gtgcggaagc tctccgctat
     6721 gccgggaatg atcgtgaaaa aacactgaat ctcggaagaa agagggactt atagtgagaa
     6781 gaaaaagaca taggctggtc cgccggaggg tcaaaacggt tgccgtgctg gctctcagct
     6841 tcgccatcat tgccggctgc tcggagacga tcccgcttga gcacaacgca gccggcgccg
     6901 gcagcggtca ggagcagtcg caatcgcagc agccgctgaa gaacgtcaag gttatgaagg
     6961 tcgccaagca aaaaatcgga gatccgcttg ttcatgccgg cgatgtgcag tcttcagtac
     7021 agtacgacat tgcggccaaa gcgagcggag acgtagaggc tattctgaaa gcccgcggag
     7081 atatggttca agaaggagaa gtcattatca ggcttaattc cacggacgcc cagtttcaga
     7141 aggaaaaggc ggcccttgcc gttcagacgg ttcaagacgc cattgcgaag gccaaggaac
     7201 gggcgaagaa agacatggat aaccagaagc gggagcttgc caactccatt caaaagagcg
     7261 agcaaaattt ggtcgatctg accaaaacgt ataacaagac caaaaacgat tacgaggtcg
     7321 ggctggctac gaagctgcag gtgtaccaaa tggaggttca gctccgcaac gcccgcatgg
     7381 atttggagca gctgaagcag aagtcggata tgcttgagcc tatcgatgcg acttccgaat
     7441 tggaaactca gctgaaaggg gctcaaatga cgcagcttca ggtagagcaa tcgatgagtt
     7501 acttggaggt taaggcgccg gcgagcggga tactgaccga gatgccgctc gaaacgggga
     7561 tgtcgctgca gcaaggagcc aaaatcggcg ttattcagaa gctggacccg atcaagatca
     7621 aggcccaact gaaggaagag gaatataagt atgtcacggg aaaatccgag ctgacctatt
     7681 atttgcaggg ggcggcgcag aaaaataaag ggaaaatcag cttcttggcc aaggtaatcg
     7741 atccggatac gaaagcgtac gaaatcaatg tcgatgtacc gaaccaaaat atggagttaa
     7801 agcccggaat gaaagtatgg ctgcaattga cggaggatca ggatcagatc gtcgtggcgg
     7861 tacctactta cagcatcgtc aaggaaggcg acgacaacta tgttttcgtg ctgaatgggg
     7921 atacggtcga gaagcgcaaa gtgcagctgg gccggctcaa cgattctatc caggagatca
     7981 cctccggagt gaatgagggc gagcaagttg tcgttgaagg catgaatcag ctgaatgata
     8041 aggaaaaagt caagtccgct gctgtggaac agcaaaaata aaattggagt gaaccgaatt
     8101 gataacgaag tggaaacgaa tcttggtagt attcgccttg ttggtctcct tgctgatccc
     8161 tccgatgcct cctctcgcga cggctcaaga gggggcgcct gcacctgcgg attattatgt
     8221 gacggaaacg gtgaaagcat cggtaaaaaa tattcttaac gagcaggcgc ccgaaggggt
     8281 gagaatcgcc gccgtcgtca gactgtataa cgaaggctcc cgtctgaccc gggtgccgga
     8341 ttatgaagtg cgggcaaaga cggacggtgg aatcgagtat acgcttcggc cgagcgcggc
     8401 caacgctatt gcgatacagc ccaaggaaac cgtcgagctg acttacatga ttgtcgtcga
     8461 ccgggaggac gccttctcgg tatcacaaat ctcgtgggtt gacgtggatg aattcgtctc
     8521 tccgagaaaa gaaacgacga tgctgtcgat tcccgtatcc tcgattgaat ggagagggga
     8581 tctcggagca ttcagtgatc cgtcggttaa taagcagtgg ggtgaagcct tcacgatcgc
     8641 cgagctgtcg ccggttatcg aatataagcc gatcagtctg atagagcaga atacgcccca
     8701 gggaccgaaa agcattctca cgctgcttgc tgagaacaaa ggcgataaga agaaaacgat
     8761 cccggatttc ttgatcaacg gcaaagccga acaaaaagta tttaccggca agaggctgga
     8821 gcaggatgcg gtagctcttg aaccgaacga gcagaaatat attcattacg ccattcccgc
     8881 aggaaagaag gaggaaatga agagtctcac cgttctgacg ccggaaagct tcgcggttga
     8941 cgataagacg aagatcgatt attccatcgg ccggttcagc atcgcgcttc cggacggcaa
     9001 tgccgccgcc gcttcggttg agcagtccga accttatgaa atgaatcaat ggattcgttt
     9061 cgatccgtta aaccgcgtca ttcagcccga aatcggcgtt gcgctggtag atttgcacat
     9121 tcatgacagc gtaggcggtg gctttaaggc ggcagtcgcc aagttcaagc tgcaaaaccg
     9181 cagcgatcgc cctatgcccg tccccaaatt ccaggcgcag ttagtcagcg cggcgggcaa
     9241 ccaatatacg ggaaaccggc aaactaccgt agtggagaca ttagccccga atatcagcta
     9301 cgtcatctat tatacgttcg tgcttcccac gacggagaaa ggcgaacggc tgacgatgga
     9361 aattttggat ggtgacagcg ttgctcccta taatatccct atcgccagac tgaagacgaa
     9421 ggctcaatcc gatcaaagcg atggagatat ccagttttac ccgttcacgg tcaaattcaa
     9481 cagctggaaa gaagaggtgt tctatggctc ggcgaagtcc agtctgcctt attcttacaa
     9541 gctgaccttg gatttggacg tgaagctgca agatcaatcc gtcgtcgatc agagcttccc
     9601 caaattaaag gtcgagctcg tagacgcaag cggcaatgtc ataggctcaa aggcgcttcc
     9661 tttcaccggg gacaaccgcg tagccagcgg catacaaacg ttcagcatgg attcgacgct
     9721 gttcgaattt tccaatacgc tgcgcgtgta tgaaacggtc gacacgcctt tcggagaagc
     9781 ggatcggctc gttgcgacgc tccaataaag attcctttag aatggctgcg gaagcgcaag
     9841 aaaccgattg acagctttcg atgaagatgc tattctgaga tcgttcttaa taaagaacaa
     9901 tatttgttcg ttatggataa ttcgaaatga ctaattcatt ataacgaact tcgctcgggc
     9961 agcggaagcc tggaatcatg tcggattacg gaggaacagg atgagcgcca tcgctggaat
    10021 ttatcattta gacaacgagc cggtacttgc cgagcatggc cggacgatga tgcgagagct
    10081 tgagaaatat cctgccgatg cgatccgtac atggaacagc ggggcggtat tcctgggctg
    10141 ccatgtccag cacattaccc cggaagccgt ctatgagcag ctgccctact atgacgccga
    10201 caggcagatt gtcattgcgg cggatgcgat attggataac cggccggagc tagttcgctt
    10261 gctggaagtg gattatgagc gcaggcgcaa gattaccgac agcgagctga tcctgcttgc
    10321 ttacgagagg tggggccagg aggctccgca gcatttgatc ggcgacttcg cctttatgct
    10381 gtgggatgca aaagcgaggc agctcttcgg ggcgagagat ttctccggct cgcgcacgct
    10441 gtactactgc cgcagcggca tgcgtttcgc cttctgcacc gtgatcgggc cgcttctgtc
    10501 gctcccgcgc atgaaagcgg aactgaatga aagctggctg gcggaatatc tcgccatatc
    10561 gggcatgatt gatgttgtcg acacggcggc aaccgtctat aaggatatcg agcagctgcc
    10621 gcctgcccac agcatcacgg tgacgtcatc cggagcgagg ctcagccgtt actgcacctt
    10681 gactcccggg aagccgctgc ggctgaaatc ggacggagaa tacgtcgagg cgtttcaagc
    10741 cgtgttcggc gaggccgtaa cgagccgttt gcgcacgcat cgtcaggtag gggcccaact
    10801 gagcggggga ttggattccg gctccatcgc cgggtttgcc gcaggagcgc tgcgcaagga
    10861 gaacaaaccg ctgcatacgt tcagctatgt tccttccggc gactttcatg actatacttc
    10921 caagcggtat atggcgaacg agcgtccgtt cattgaagcg acggtccggc atgtcggcaa
    10981 tatccgagac cattatctgg atttcgaagg gagaaattcc tttctggagg tggaagactt
    11041 cctcgatttg atggagatgc cctacaaatt ttttgaaaat tccttttggc tcaaagggat
    11101 cttcgagaaa gcccgcgacg agcaggttgg ggtgctgctg aacggcggcc ggggcaatct
    11161 gtctatctcc tggggatcgg ctaacgagta ctacgctatt cttctcaaaa ggctgaaatg
    11221 ggtcaaattg ttcaaggaac tggaccaata cagcactaaa accggaggaa gccgctaccg
    11281 ccgactgcct ctcatagccc gaacggcctt cccgtttatc gataggatgg tccctcaggc
    11341 tgatgcttac ccgttcccgc cgctcattca tccggaattc gcccgaagga ccggagtatt
    11401 taaaaagctg cagcgcttcg acatcgacga atccggctgg tacggcggta tagatgctta
    11461 cgagatgaga aaaaggcatt ttgaagagct gtttcattgg aatgcgagca atacgctggc
    11521 cgcgaagctt tcgctgcgct acggcttatg gaagagagat ccgacgaacg atctgcgtgt
    11581 gatccgcttt tgtctgtcgg ttccggagga gcagtatgtg caaggcggga tggaccgggc
    11641 gctgatccga agggctacgg agaacgtgct gcccgatcag gtcaggctga atcagaaggt
    11701 tcggggggta cagggtgcgg attgggttca ccgtatgatt ccgcattgga acgcatttag
    11761 ggaagagctt catcggctct gcgccgacga gaggatgcgg caaatattaa acgttcctgc
    11821 aatagagaag gcgctgcaca agctgcggga aggggttcgt cccgaacatg cgatcgaccc
    11881 ggattataaa gtcctcatgc gcagcttgat cgtctaccgg tttataagcc gattaacatg
    11941 aagggaggtg aataaagcat ggtgaaaaaa gagtggcagc agcctaaatt ggaagtgctg
    12001 gatgtgaagc agacgatggc ttcgactcat aacgggcctc ttaccgatga agcttacata
    12061 ccgggcagaa actctgatga tcctcgcttc actagctaat gccttattta tagcttcagc
    12121 actaagggcc cttatacatc accgagagta taggggctct tctcttagct taaccaaccg
    12181 aacgtgtttg gagtgagtac catgattcag acggaaaata aggtcgtata caaagctttt
    12241 gacttatcca tcgcaagcgg catggaattg ccggaattgc ctgtgattca tcgcagtacc
    12301 gggcgggccg atgtggaaat catagtcgat cctgctgcgc ggttcggagc cgggctcgaa
    12361 agccgccctt attaccatga cgtgcggaac ggagaagtga cgttccatgt tcccggcaat
    12421 gcgaattact cgattcggga aggaagggtc attacggtag cgcctctgcc gtcggccgat
    12481 gaaggtctga cacggctgta cgtgctcgga acctgcatgg gcgcgctgct aatgcaaaga
    12541 agaaagtatc cgctgcacgg aagcgccgtt gctatcgggg gcaaagccta tgccatcgta
    12601 ggggaatcgg gagcgggcaa atcgaccttg gcttccgcct ttatccaggc cggctatacg
    12661 ctggtaagcg acgatctgat ctccgtatcg ctgtctcccg tggacgaaac ggctgtcata
    12721 acaccgtcgt ttccgcagca aaagctgtgg cgggaaagtc ttgagcagtt cggcatggaa
    12781 accggtacat accggtcgat ctacggcagg gagaccaagt acagcgtgcc cgtcgcgacg
    12841 cattattgcg ctcagccttt gccgctcggc ggcgttatcg aactggtcaa aacggaggag
    12901 ccggaggttt ccatccatcc aatctccaag ctggaccggc ttcagacgct tttccggcat
    12961 acgttccgcc attttctaat cccccgtttg ggcctgatgg aatggcattt ccaaacttcg
    13021 gccgcgatag cggggcaggc agctatgttc caattgagaa gacctgccgg cggttttacc
    13081 gctcctcagt tagtatcgct gcttttagag aatttgcgta tggaggaata gagcatgatt
    13141 ccaaatcaaa gtattgcttt aaccgatcgt tttgtgcaag gagcgggaaa tatcgtcagc
    13201 gacatggacg gggagaaagt aatgctgagc attcataaca gcaagtatta caacttgggc
    13261 gaagtcggag gcgacatctg ggagcagctg gcgcagccgg ccgaggtaga gcgtatcgta
    13321 gattcgctca tgcggcaata tgaagtggag cgggacgatt gcgagcatca ggtcgtatcg
    13381 tttctgcagc atttgctgga ggaaggatta attcagtggg cgtaatacgc aaagctagaa
    13441 attggctttc tttagattgg aaaacaatgc ttgcttttat cgaagcttat gtatatttag
    13501 gctgggcgcg atttctcgtg tcacggccgt ttgccgaaat aacgccttcg ctcggcgagg
    13561 cgatggaaga gactcccgag acgagtctac cggaacaaga aggacggtta agggtcgttt
    13621 acgacgcggt tcagattatg agccggcata cgttctggga gagcaaatgc ctcgtcaggg
    13681 cgatcgccgc tttgaagatg ctggagaggc gccgtatcga gagcacgctg tatctgggaa
    13741 cggccaagga tgaagcgggc aagctgatcg cccatgcctg gctgcgcagc ggcccttact
    13801 atattacagg agcggaagaa atggggcggt tccgggtagt cgggaaattc gccaaacgga
    13861 taagcgataa aggaaaatga aggtgaatac aatgagtact gattttcgtt tggatacggc
    13921 gtctttcccc gaggagctga acctcatgct tgccctgctg ggcggggaag cgggcgataa
    13981 gctgcaagcg gccgggatcg actgggactt gtttctgcag ctggcaagac atcaccgggt
    14041 ctatccttcc ctgtaccata agctgcagca ggccggaata agcgcgattc ccgcgcatgt
    14101 gatgcaagcg ctgcgcgccg attaccagca aaacatattc cggatgctgc agctgagcgg
    14161 ggaaatggag cagatctgca gaacgctcgg cgaagcgaac attcgcacgc tagtattgaa
    14221 gggacccgtt ctggcggccg atctatacgg cgatctgtcg cttcgcacat gcggagacct
    14281 cgatctgctc gtcccgatcg atgatctgga ccgggcggag cagctgctcg gcctgctcgg
    14341 ctatatcaaa gacgaatata tccaaaccgt actaagcgac tggaaatgga gacatcatca
    14401 tatcaccttc tttcacaggc acatgggaat caagattgag cttcattggc ggctcggccc
    14461 gggccccgga agcgaacccg gcttctactc cttatggcaa agaaagagac tcagcgcgat
    14521 tacccggcat cccgtttatt acttggggag agaggattta ttcctgtttc tggtctccca
    14581 cggggcgcgc cacggatggt cccggctgcg ctggctgacg gacattcatc agctgtgccg
    14641 gcagccgctg gatgataaca agctccgcgg gctgctggtc aagtatcgta cttcgcatat
    14701 cgcggcgcag gcatggatat taacctcgca gctgctgcat acgccgctaa gcgaatcatg
    14761 ccgccgatgg tcgaaggagc agcgggcgcg aagtctcgct caaggagcgc tctactacat
    14821 cgggcaaatg atcaatctgc actccgagcc gctgccggaa gacgtgtccc ggtatcacaa
    14881 acgccatctg ttcgcgctca tgtcctgtca gaccaagctg ctgtttatca tgagcctctt
    14941 gtatccgtac ccgcatgacg cggagacgct ggcgctgccc aaagctttgc actttcttta
    15001 tttccctctg cgtccttttc tgtgggcttg gagaaaaaca aagaaagtac gccttatcgt
    15061 agcaaggagc ggaataaaat gaagcaggtg ctgtacttcg cccgcaagat gcatgcctat
    15121 gccggaaata ttttatttgt caatctgctt gggatgacgc ttgtcggctt tctcgacgga
    15181 ataggcatgt tcctgctgat tccgctgctg agtctgatcg gcatcctcca aatcaacgcc
    15241 ggaagtatcc ctttggcggg cggcttggac ttgctgaagg agctgccggg accgctcagc
    15301 ctgctgatcg tgcttgcgat ttatgccgcg ctcgtgatcg ggcaggcctt aatccagcgc
    15361 aatttaagcc tcagagatat tcgaatccac accgggttta tcaaccacgt tcggatggaa
    15421 acgtatcgat ccctgctgca ggccgattgg gacttcttta ttaaacggag aaagtcggat
    15481 ttcatccatg cgatgaccga cgagctcggg cgggtgacga acggcacgta cgtatttctg
    15541 cagtttgcgg cgtcgctggt gtttaccctc atccagatcg ccattgcatt ctggttatcg
    15601 gccaaactga ccttgttcgt gataggctgc ggtctgctgc tcgccttctt ctcccgcgtg
    15661 ttgatccggc gatcgagaac gctcggcggc caaacgtcgg agctggccag gagctatatc
    15721 gccgggatta cggatcattt taacggaatt aaagatatca agagcaatat gctggaggaa
    15781 tcccgcaacc gctggcttgc ggagtggtgc gagcgaatcg gcgaggagag gtacgggcac
    15841 gccaaactgc gctccgactc ccagttgtac tataaggcgg cctccgcatt gatcatagcg
    15901 gcattcgtct acttatcgag ctacctgttt catacgcaag gggggcaatt gctgctcatc
    15961 atgatgatct tctcgcggct gtggccgcgc ttcaccggca tccagtccaa tctggagcag
    16021 atcgcttcgg ccctccctgc gtttgcctcg ctgcttcagc ttcaagagca gtgccgggcg
    16081 tcaagagaaa tccgggacgg cgagcttgcg ccggaggacg tagctccgct tgccgtggag
    16141 cgcggcttgg aatgccgcgg cgtcagcttc cgctataacc ggcaggagcc ggtgcgggca
    16201 ttggagcgga tcgatctgta cattccggcg atgcggatga cggcggtgat cggacggtcc
    16261 ggcgccggga aaagcacctt gatcgatatg ctgatggggc tgctgcggcc cgaagaaggg
    16321 caagtgctgg ttgacggcgt tcccttaggc ggccgtcttc tgcagcgtct caggaaggcc
    16381 gtcggctatg tgccgcagga cccgctgctg ttcggcggca gcatcaggga gaacctgctt
    16441 ctgatcgatc cggaagcatc ggaacgtcag ctgtgggagg cgctggaatt cgcggccgcc
    16501 gacgaattcg tcagacggct gccgcaaggg ctggatacgc tgatcggaga ccgcggagtg
    16561 cggctgtcgg gaggggaacg ccagcggctt gttctcgcca gagcgatact gcgccgccct
    16621 tcgattctcg tgctggatga agcgaccagc gcgctggacg ccgagaacga agcgcggatt
    16681 caggaggcgc tggagaggct caagggcaag atgacgatcg tcgttatcgc gcatcgcctg
    16741 tcgaccattc gcaacgccga ccaagtcgtc gtgctcgatc agggcaggat cgttcagcag
    16801 ggcggcttta cgcagctgtc caaggagcgg ggcaagctgt tcgcacattt gctgcgcaat
    16861 cagatgatgc cggatgccga gaataacgac ttggagcagc tgcctgtcta gctggaggaa
    16921 ggagggaagg aatgaaggcg aaggtaagcg taattatacc cgtttataat gccgagcggt
    16981 acttagccga atgcatcgag tctctaatga agcagtcgct tcaggaatgc gagtttctgt
    17041 ttattgacga cggttcaacg gatcggagcg ccggcctgat tgagacatat gccgggcagg
    17101 atagaagaat ccagctcatc cggcaggaca accagggtgt cagcgccgcg cgcaacaccg
    17161 gtctgcgggt tgcgtccggc gagtatgtcg ggttcgtcga tgcggatgat tatattgaac
    17221 ccgatatgat ggccgttcta tacgaagcgg ccggacagta tgccggcgat gttgtcattt
    17281 ccaacttcga aagcgagatc gagggccatt gggtgcagac cagctatccc tttcttacta
    17341 acaggctgct tgaccgggag tttgtcagga aggaaatatt gccttatttt ttaagatccg
    17401 accaattgaa ctcggtgtgg aacaagcttt acagaaatca actgattcaa gattgcggcg
    17461 cggcctttcc ggataaggta gcgcttgggg aagacgggat ttttaatatg cgggtattct
    17521 gccatgcctc caatgccgta tatctcgatt attgcggtta tcattaccgc gaggtcgacg
    17581 gcagcgcgac aaggaatatc atcggcaaag attacttcca gcgtgcgctg gaggtgtatc
    17641 ttacggatgt ccccgagatg aaagccattc cgctaagcag ggaagaaatc cgtaagctga
    17701 aggcggtccg gctagtacat agcgtcatgt cgtatgtgta cctttatttc caagctgcgc
    17761 aaaaagtgag ttttaaggcc aggttcgctt atgtcagccg gatgatagcg aatccgcatg
    17821 tgcaagaagc gctggctttt tacgccgatg aaaaagccgg gaaattggga cgctacgacc
    17881 ggtggctgtt ggaggcaata cgcgggagat cggcgataag tctctactgc atcacgtctt
    17941 atagcaaatt gagaagcgcg gcgaataaat agagtgatat cgtgaatgat ctggctaatt
    18001 aacgggagga ataaggaaaa tgaagattat gatgtttgct catggcggaa gcttgaacag
    18061 aggctgcgag gccattgtga ggtcctcaac aagtctgatt aaagagcgaa tccgcgatgc
    18121 gaaagtatac ttggcgtccg gcaagcccga taccgatcag atcatcacaa aattggacgg
    18181 catttatgac ggatctgccc gaggcatccg gaaatattcc tatgactggt ttgtttccgc
    18241 cgttaaaatg aagctgtttc aggatgaaac gtatgcgctc gggaaaattc acgataacat
    18301 tgttagacat attcccggca tggatgtctg tttatcgatt ggcggagaca attactgcta
    18361 cggggaacaa ccggggtggt atgagattaa ccggagagtc aaagcatcgg ggaaaaaatt
    18421 ggtgttatgg ggctgctcaa tcggtgagga ggatatgtcg gaaaagaaac ttgaggattt
    18481 aaagcgattc gaccttatct tggctcggga gacgctgacc tataatatgc tggttcagaa
    18541 agggctgact aacgttcaat tatgcgccga tccggctttt acgatggaga aagaagagct
    18601 ggaactgccg tcgggttggc aggatggcaa tacggtcggt ctaaacttta gtccgcttgt
    18661 atggaaacgc aacgttcaat ctcagcaagc agtgcgggag ctgattagcc atatactgac
    18721 cacgaccgat atgaccatcg cgctgactcc gcatgtaatg gaggggggca ataacgatta
    18781 tgagatgctt cggcagtatt atgaggaatt ccgagctaca gaccgagtga ttttgctgcc
    18841 gggagattta aatgccgttc agtataaggg ctatatttcg agaatgagat tttttgtcgg
    18901 cgcaagaact catgctacta tagcggctta ttccaatttc gttccaacga tggtattggg
    18961 atacagcatc aaatccaagg ggatttccaa agatattttc ggtgaggaaa agctggtgct
    19021 cggaattaag gaaatatcag acggtgtcct tcttaaagca aaattcgacg agatgatccg
    19081 ggaagagcga gaattgaggc agcggctgca aacatcgatt ccgcacataa aaaaaatgtc
    19141 ttataaagcc gttgaacatc ttggcaagct ggttcagagc cgttgaggtg gagtatgaaa
    19201 aaaaatctgc tatttattat gccgagccta atgtccggcg gcggggaaaa aagcctggta
    19261 actctgctga atcaaattga tttccaacaa tacaatgtcg atttgtttct gttggatcat
    19321 aacggcctgt ttatggaact gatcccggag aaggttgagc tgctgccttt aacgggagtg
    19381 tatcatgagt tcaggctgcc tatgcttaag gcgttccgga agctgttgcg gcaagggtat
    19441 attgcacttg cgtttcaccg aatagcattt actttgagta atagaggcaa gcgcaacata
    19501 tcacaaagag aacagtacag ctggaggcac atggcttcat ttttagaccg gctgcctaaa
    19561 acttatgatg cggctatagg gtttatggag aaaacatcca tctacttttg cgtcgataaa
    19621 gtgaatgcgc atcaaaaaat agggtgggtt catacggatt atgatcaaat gggaatggat
    19681 tcgcggttcg atcaccatta ttacaagcaa ctggaccgta tcgtaacggt gtcggaagag
    19741 tgtgccaacg tattaaaaag acgatttccc gatcaacaac ataaggtgga ggtaatatat
    19801 aatatcgtat ctcccgaatc tatcatctct ctggccaacc aatcgaaaac ggatgtatat
    19861 caaaaaaaca aagatgaaac gatcatcgtc tccgtgggaa ggcttcacga ccagaaaggc
    19921 ttcgatatgg ccattgagtc atgcaggaaa ctggttgacc ggggatatcg cattaaatgg
    19981 aatattatag gggaggggga agagagagga cgactggagc atttaattca agaatacgat
    20041 ttatgcgatt acgttcgatt gctgggttta aggtcgaatc cttatcccta tattaagcag
    20101 gctgatattt acgcgcaaac ttccaagttt gaaggcaagt ccattgcgat cgacgaggcc
    20161 aaaatactaa acaaacctat tctggttact aatttcagta cggctaggga tcagatcagc
    20221 gacggcgtcg atgggctcat tgtagacatg aacgcggagg cgatagcgga aggtattgaa
    20281 atactcatta acgataagca gttaagaacg agattaatct ataacttatc ccgaacggcg
    20341 ttaggcactg agggagagat agaaaagttt tatcaattgt tgacttagta cggaagcgat
    20401 ctgctccgat ttctatcatc aagttgcagg aggaaacgat gaagcagaag atattgtttg
    20461 tcatgaacaa tttgcaatgc ggaggcgcgg aaaaagcgct gatttcgctg ctcgagacga
    20521 tcgattactc cttgtatgag gtcgatctgt atttgctcag gcactcggga atttttatga
    20581 gcaaaatacc ggcagcggtg aagctactgg gagaaccgca agaatatcag tattacgata
    20641 tgccgattcg caaagcggtg ctcaactgct taaaacgggg caggattaac attgcttcat
    20701 tcagactgcg ggcgggtgtt atctataaaa cggaaaaaaa cagcgttcga tgtgagcaga
    20761 gagtgtggaa gtatctgtcg aaatcgttga aaagcataga tcaggtctac gatattgcca
    20821 taggctacct ggaaaaaaat ccgatttatt tctgtattga caaagtgaag gcacgtaaaa
    20881 aaatcggctt tattcacaat gattatgacc gcttgggcat ggacccttcc tatgataaga
    20941 cctacttcga taagctcgat catctagtta cggtgtccgg ggaatgcggc actattttga
    21001 agaagcggtt tccgaagtat gcgcacaagg tagaagtcat gcataatatc gtatcgccgg
    21061 cagcgattcg aaatttggct atggaagatg cggactggaa cgccgcaaac acgatacccg
    21121 attcgcccgt cgggcaaacg ccgccaatca agaaggattc cgcgataaag ctggtttcca
    21181 tcggccgact aaattatcag aagggctttg aaatggccgt acaaacctgc aaggagcttg
    21241 tagaaggagg atatcctgta caatggtatg tcattgggga aggagaggag cggaaaacac
    21301 ttgagcgaat gattagcgaa aatgggcttc aagaccggtt tcacctgctt ggagtgaagg
    21361 aaaatccgta tccttatatc agagaggccg atatttacgt gcagccttcc agatttgagg
    21421 ggaaatccat cgcgatagac gaagccaaaa ttttgcataa gccaattgtt gtcaccaatt
    21481 tcagtacggc aaaggatcag atcaccgaca gacataacgg attgatcgta gagatggatg
    21541 cccggtccat cgctcaagga atcaaggcgc tattggaaga tgcttcgttg cgacggcaat
    21601 tgtcggttaa tttagagaag gagccgcttg gcaccgaaac ggaaatcgaa aagctgtatg
    21661 cgttatttga ctcaaaaaaa taagcaaggt agaaaggaca gattctgtga tagctctcat
    21721 cgtatgtcta ctgctgtttg ctctcatcat tgtggtcata ttgatcgaca ttgtccctat
    21781 cttcaaagat tggctgagcc ggattcatat tggaagattc caagacaagc aactatggag
    21841 ccgctcgatc acgaacgtcg gaattcaatg gctcaatcat actcctcaaa ttaaagtgac
    21901 tgataatacg agactggtcg ctatcgatat gctgaagggc aactattcga agaactctat
    21961 tcagcattgg caggaagctt ccctgctcat gggtctggcc gagtatgtga agcgaagcgg
    22021 cgatcaggaa gtaaagcggg aaattgagaa gtttttggcc tccaagtttg accgtgatgg
    22081 cgagtgggtg gaaaagcccg agcaagtgga cgcggccatt ttggcttatg ccgttatgaa
    22141 gctcgatttc atcaatactg atcattacaa gaaggcgctc gagacgacat gggaacttat
    22201 tcgcgatcat ctaggaacgg acggcacggt ggcttaccgc aaatttatgc ctaactatcg
    22261 gtatgttgat acgatcggtt tcatctgccc gtttctcgtt tgctacggtc ttcgttaccg
    22321 ccaggaagct tgcgtggatt tggctgtcaa gcaaatttta tcttatgaaa agcacggcat
    22381 gctggaaggg catcatatcc ccagccacgc ttatcaaatc gataacaagc tgccgctcgg
    22441 attgtacggc tgggggcgcg ggctcggctg gttcgccatc gggcttgtcg atgcctggaa
    22501 tgagcttccc gcagggcata aggccaagaa gacgctggaa aacagtgtac gcaaattcgc
    22561 cgtcgccgcg atggcgttcc agcaagccga cggaaattgg agctggacag taacgcgtca
    22621 agaatgcaga gccgactctt caacgaccgc gacgctgggc tggtttatgc agcaggcttc
    22681 caggattgag gatatatcgg cggactgctt ggagagcgcg gaacgcgccg ttcgttatct
    22741 tatgaaggcc acccgccgaa acggggccgt cgatttctcg caaggcgaca cgaaggatat
    22801 cggggtttac tcgatgttat ttaacatatt gccgtttacg caaggctttt gtattaggct
    22861 aatgaactcc attcatgtcg gaccttaagg ttatgaggaa ttctatgtta aagaagatca
    22921 tttgtttttt gagggcgcgt attcgcaagt gcttattgga ggaattgtgg ctagaggact
    22981 acatccgaat gggaatgaga gtaggccaga actgttcgat tcagcctgga gtggtgttcg
    23041 attattcgca ctgctggctg atccgtatcg gagataacgt cacgattgct ccctacgctt
    23101 atctgttgac tcatgatgca agcactaagc agttgaacca gtataccaaa gtcggcagca
    23161 tcacagtaga ggacgatgta tttataggag ctcgcgctct aatcatgccc ggagttactc
    23221 tagggcgggg atgtattgtc gctgcgggca gtattgttac caagtctgtg cctccagagg
    23281 tcatcgttgg cggtgctccg gccaagttca tctgcacagt agaggaatat gcgcgtaaaa
    23341 ataacgagct cttggaaaag aaaacagtgt atgatcgaga cttcacgatc ggcggccgga
    23401 tttcagcgga aaaaaaacgc aaaatgtatg aagaactaat caacgatatt ggctatgtgg
    23461 tctaatcttt aaataatggg gaaaatgatg cgaacaaaaa actcgatcat caacatatcg
    23521 gtagggctcg gcaaccagct catcattacg ctgctcagct ttttttccag aacggtgttt
    23581 atccatacgc tgggcttgga ttatttggga gtgaacggac tgttcacgaa catcctgtcc
    23641 atgctctcgc tcgcagaagc gggaatcggc tccagcatta tttatcatct gtacaaaccg
    23701 gtggcggatc aggaccggca caaaatcatt ctgctgatga agctgtataa aaaggcgtat
    23761 tggatcatag ctatcattgt atcgctgctg ggattgtcgc tcatgccgtt tctcccgcat
    23821 gtcgtcaaag attcgagcgt ggagcatgtt cacctgatct atctcgtatt tttgatcaac
//
