LOCUS       NZ_JAMDIB010000004     26035 bp    DNA     linear   CON 25-MAY-2024
DEFINITION  Streptococcus suis strain LSSP240
            NODE_4_length_166856_cov_293.059234, whole genome shotgun sequence.
ACCESSION   NZ_JAMDIB010000004
VERSION     NZ_JAMDIB010000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus suis
  ORGANISM  Streptococcus suis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 166856)
  AUTHORS   Li,J.
  TITLE     The Streptococcus suis genomes of diseased pigs in China
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 166856)
  AUTHORS   Li,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-MAR-2022) College of Food Sciences & Technology,
            Huazhong Agricultural University, No. 1, Shizishan Street, Wuhan,
            Hubei 430070, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.15.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 500x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023469985.1-RS_2024_05_25
            Annotation Date                   :: 05/25/2024 04:47:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,225
            CDSs (total)                      :: 2,174
            Genes (coding)                    :: 2,095
            CDSs (with protein)               :: 2,095
            Genes (RNA)                       :: 51
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 44
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 79
            CDSs (without protein)            :: 79
            Pseudo Genes (ambiguous residues) :: 0 of 79
            Pseudo Genes (frameshifted)       :: 41 of 79
            Pseudo Genes (incomplete)         :: 34 of 79
            Pseudo Genes (internal stop)      :: 22 of 79
            Pseudo Genes (multiple problems)  :: 13 of 79
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:27:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 47066
            Orig. end                         :: 73101
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAMDIB010000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26035
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26035
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26035
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16035](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16035)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(693..1418)
                     /locus_tag="M5P35_RS03960"
                     /old_locus_tag="M5P35_03960"
     CDS             complement(693..1418)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1104: putative esterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002909732.1"
                     /locus_tag="M5P35_RS03960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_03960"
                     /product="alpha/beta hydrolase-fold protein"
                     /protein_id="WP_024394864.1"
                     /transl_table=11
                     /translation="MHVEFLSHWSGNLGREMNLNRYGHAGIPVVVFASSGGSYNEYADF
                     GMIEACQVQFFTLTSYDSESWLADWKSIHDKAEAHRAYERYVIEEAIPFIKHKTGWFDG
                     MMTTGCSMGAYHALNFFLQHPDVFTKVIALSGVYDARFFNNNQDYGNDDVVYQNSPSDY
                     IWNQNDGWFIDKYRQADIIVCTGLGDWEQDGLDSFYNLKRAFEEKSIPAWFDTWGTDVA
                     HDWVWWRKQMPFFLHSIGL"
     gene            complement(1449..2276)
                     /locus_tag="M5P35_RS03965"
                     /old_locus_tag="M5P35_03965"
     CDS             complement(1449..2276)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002935033.1"
                     /locus_tag="M5P35_RS03965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_03965"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_011922416.1"
                     /transl_table=11
                     /translation="MNKSYFYLDMRTHELDVPFTERKRRVRVLLPKGYAENTEETYPVV
                     YFHDGQNVLYSKEAFSGHSWKVIPTIKRNPDIAKMIVVAIDNDGADRMHEYAAWKFSEM
                     GIPGVQFGGKGTLYAEFVMDVVKPFIDQEYRTKSDKVHTAMIGSSLGGNITQFMGLAYQ
                     NQIGCLGVFSSANWLHQDAFDRYIERQQLDSEQRVYIYVGTEEADDTDKTLMAGNIKQA
                     YINSSLTYYRQLIAGGVDLDNIALEVVSGAVHNEEAWALYLPACLRFLSEHWS"
     misc_feature    2326..2340
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 26.38"
                     /tool="antismash"
     gene            complement(2390..3394)
                     /locus_tag="M5P35_RS03970"
                     /old_locus_tag="M5P35_03970"
     CDS             complement(2390..3394)
                     /GO_function="GO:0019104 - DNA N-glycosylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036297 - interstrand cross-link repair
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012775107.1"
                     /locus_tag="M5P35_RS03970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_03970"
                     /product="crosslink repair DNA glycosylase YcaQ family
                     protein"
                     /protein_id="WP_024394865.1"
                     /transl_table=11
                     /translation="MHHNTWKGIILQKQGLLNPQSVQQICQNLNGLQAQFQPYVHVGFR
                     NRMTAEDFHEGSWQEELTRQWSIRRTVHAYLESEIPLYIHEGRLVSTDYLKTEGRDGFS
                     PQTKQKYHHLILEALEQGPMTREDLKVLCREEKMTQKEEKLVFNAWGGLFRYMVERGEV
                     YQEYGAKRFHRLTDFQPLSREKAELEIARRYFSGFGPVSLADARYYFKENKSTILEWMA
                     QLDLKTIQVAGEERFYLGVLDEADLPQCLFVAGFDQLLLGYEKKNNPFFDPKYIRNIYT
                     LTGIVKPVVFYKGRFVATWKRDKGTILLDIFEDITQQEEKELEHYRQMFEKIL"
     gene            complement(3459..4294)
                     /locus_tag="M5P35_RS03975"
                     /old_locus_tag="M5P35_03975"
                     /pseudo=""
     CDS             complement(3459..4294)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014636394.1"
                     /locus_tag="M5P35_RS03975"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_03975"
                     /product="AraC family transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIKEFNATVRYLESF"
     gene            complement(4371..5705)
                     /gene="trmFO"
                     /locus_tag="M5P35_RS03980"
                     /old_locus_tag="M5P35_03980"
     CDS             complement(4371..5705)
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_process="GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /gene="trmFO"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011922419.1"
                     /locus_tag="M5P35_RS03980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_03980"
                     /product="methylenetetrahydrofolate--tRNA-(uracil(54)-
                     C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO"
                     /protein_id="WP_024394866.1"
                     /transl_table=11
                     /translation="MSQTHINVIGAGLAGSEAAYQIAKRGIPVKLYEMRGVKPTPQHKT
                     DKFAELVCSNSFRGDSLTNAVGLLKEEMRRLDSIIMRTGEAHRVPAGGAMAMDRENFSQ
                     AVTDEIHNHPLIEVIRGEITEIPEDAITVIATGPLTSDALAEKIHALNGGDGFYFYDAA
                     APIVDSSTINMDLVYLKSRYDKGEAAYLNAPMNKEQFNAFYEALISAEEAPLNSFEKEK
                     YFEGCMPIEVMAKRGIKTMLYGPMKPVGLEYPEDYKGPRDGEYKTPYAVVQLRQDNAAG
                     SLYNIVGFQTHLKWGEQKRVFQMIPGLENAEFVRYGVMHRNSYMDSPNLLEQTFATKKN
                     PNLFFAGQMTGVEGYVESAASGLVAGINAVRRFHGEEPVIFPQTTAIGALPFYITHTES
                     KHFQPMNVNFGIIKELDGPRIRDKKERYEAIAERSLKDLEEFLTV"
     gene            complement(5901..6652)
                     /locus_tag="M5P35_RS11220"
                     /pseudo=""
     CDS             complement(5901..6652)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015646823.1"
                     /locus_tag="M5P35_RS11220"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="HAD family hydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKSYKNYIFDFYGTLVDIRTDENKLEVWNQLTQIYNAFGCSYRPR
                     QLKNAYHRFVEEAESSLAETVSYQYVEIDLETIFIRLLTDAPNENQSTNKPTDLETFGQ
                     VVATIFRVLFHVKS"
     misc_feature    complement(6702..6713)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.81"
                     /tool="antismash"
     gene            complement(6837..8036)
                     /locus_tag="M5P35_RS03995"
                     /old_locus_tag="M5P35_03995"
     CDS             complement(6837..8036)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002943304.1"
                     /locus_tag="M5P35_RS03995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_03995"
                     /product="site-specific integrase"
                     /protein_id="WP_024411335.1"
                     /transl_table=11
                     /translation="MATKSSKKYKGVYCDNKGKIFYQIDLGIDPVTGKRVQKKARKNQY
                     GKTFETMKEAYDELVRIKYEFANKVSLENYNMTFENYMNTIYLRAYKQKVQSVTYKTAL
                     PHHKLFIQYFGSKLLKAITPRDCEAFRLHIIENYSENYAKNLWSRFKACMGYAERLGYI
                     SDMPCKALDNPRGKHPETPFWTYAEFQTFIKSFDLNDYEELQRFTAIWLYYMTGVRVSE
                     GLSLCWEDIDFENKFLKVHTTLEKDENGNWYRKDQTKTPAGERLIELDDITIEVLQVWR
                     KNQFANQDTDFIISRFGDPFCKSTICRIIKRKAQQVGVPVITGKGLRHSHASYLINVLK
                     KDILYVARRMGHADKSTTLNTYSHWFNALDKTVSEEITQNIKSAGLDSILCQNSCQTSN
                     "
     gene            complement(8059..8286)
                     /locus_tag="M5P35_RS04000"
                     /old_locus_tag="M5P35_04000"
     CDS             complement(8059..8286)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003106749.1"
                     /locus_tag="M5P35_RS04000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_04000"
                     /product="DUF3173 family protein"
                     /protein_id="WP_001258320.1"
                     /transl_table=11
                     /translation="MRTATYKDLMNLGFPEHTSRDIIREAKRIAVKKFEEARKVDHNAV
                     QLSKSPFDNRRLGIAPAEIVEQLIGIPLSK"
     gene            complement(8611..9015)
                     /locus_tag="M5P35_RS04005"
                     /old_locus_tag="M5P35_04005"
     CDS             complement(8611..9015)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018368528.1"
                     /locus_tag="M5P35_RS04005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_04005"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_000878635.1"
                     /transl_table=11
                     /translation="MKYYIHVRGSKIPVTETVYKSYWQLVNHEKYLNRKDRKFGVLPFS
                     SFEVDGLLLANVLPDTTVDVERFIENKLLIEQLNEALLTLSDKEFKIIDALYFREHTIR
                     EVAIEHEMSATSLFRMRNTILDNLRKFFEK"
     gene            complement(9283..9999)
                     /locus_tag="M5P35_RS04010"
                     /old_locus_tag="M5P35_04010"
     CDS             complement(9283..9999)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001226539.1"
                     /locus_tag="M5P35_RS04010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_04010"
                     /product="NisI/SpaI family lantibiotic immunity
                     lipoprotein"
                     /protein_id="WP_001226539.1"
                     /transl_table=11
                     /translation="MRKILFSLVVLIGICTLVACRLVDNKTIEFHDQSFNQFTYKGNDY
                     TIMNQIVDENDLGTVKESFFKTLVIDRNSQKVVTKSNSDTVSLAYSGLYNFSDGLAISI
                     NDSYYKVSLSSDVQSNNEMLSLEEFNNNSAGGELAIDPSDCRIVKFNNKKFRISSDIVS
                     DDKLKEFLGVIADSKTFILNTGQEISKSELNKIDYSGSNSNEKREVWDYGEVYLLAEEG
                     TIAVEINNEFRIARIE"
     gene            complement(10001..11278)
                     /locus_tag="M5P35_RS04015"
                     /old_locus_tag="M5P35_04015"
     CDS             complement(10001..11278)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000344171.1"
                     /locus_tag="M5P35_RS04015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_04015"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_000344171.1"
                     /sec_met_domain="LANC_like (E-value: 2e-58, bitscore:
                     191.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDENKVIIDLSEKVFAKFDEQLKRYAEQPNYDLLTLSSGLPGLIL
                     LSSELTSLTSERKYSARTGKYVNFMVKQMRNYGVLSDSLFSGVSGIGISILHLVEEHPE
                     YHNLLISFNEYIKYYTLSKIENIDIKKISPTDYDIIEGVSGVLVYLLSQEQDENDYIIN
                     RIINFLSEFSLKNSTLTGFYVESKNQMSKTESKLYPLGCLNFGLAHGLAGVGAMLSYSK
                     LKGYSNEKSIAAIKKIIMLYEKHELKNYMWKEGLSDIELKKTEKSNLQYEFIRDAWCYG
                     SPGISLLYLYSSLALEDKKLKSKACNILKASIRRSNGLEQSILCHGFSGAIEICLFFKK
                     IYKTTDFDDCIKSLKEKLISDFREDMTYGFNTTAEFENIKTKDNLGYLDGIIGILLTMI
                     ELNNLKVTTNWQRALLLFDDVIKEVK"
     gene            complement(11271..13067)
                     /locus_tag="M5P35_RS04020"
                     /old_locus_tag="M5P35_04020"
     CDS             complement(11271..13067)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002943315.1"
                     /locus_tag="M5P35_RS04020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_04020"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_031912841.1"
                     /transl_table=11
                     /translation="MDKFTLKNFFQTILTIPKTIRLIFRIERKYASYLIILNILQSIIP
                     LASLFIYQELINAVLKKGSNIFSVLIVYILMQMMLSILSQLNSYISEKFNMNLSYNLNL
                     KLLKKTSSLNLIDFEQADTYNLIENIVQDSTYKPFQLFNAIIGVITGFLSLLTSIIYVS
                     TWNVAVSTFLLIIPVISLVIFMRVGQLEFLIQWERANSEREVWYINYLLTHDFSFKEIK
                     LNGISQYFIDKYGTLKRNFMNQDLNISKKKVLFRGSLDILLNFINGIAIFMMIQSIRSG
                     KLLVGNFVSLIQAITRVNTYSQSMIQNTYIIYNTSLFMEQLFKFFDMEVSNISIQNSRI
                     SRIEKRIDKIKVNNLSFIYPGSVKKTLEDINVEFNKGELVAIVGKNGSGKSTLVKLLSG
                     LYQPSEGQIYYNNESSDVLDLSYYQNNVSVLFQDFVKFELSVRENIGLSDVNSISDSKI
                     KKHIDNLKLNFLTAENNFNLNQRLGTWFNDSRQISGGQWQKVALARTFFKNASIYILDE
                     PSSALDPVSEKEIFDEFVTRSRDKIALFVSHNLMAASRADRIIVMQDGRIIDEGKHDDL
                     ISKSKYYRELYYSEKYEEESDG"
     gene            complement(13060..16035)
                     /locus_tag="M5P35_RS04025"
                     /old_locus_tag="M5P35_04025"
     CDS             complement(13060..16035)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400478.1"
                     /locus_tag="M5P35_RS04025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_04025"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_000400477.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.8e-91, bitscore:
                     298.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.4e-07,
                     bitscore: 25.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.3e-21, bitscore:
                     70.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHKYTTNNFLVRNAIIGIHELLECDYNSFLETIRENKIFQEQLF
                     VASRSLYESLQKYYSGDSMKRKKINQLSESVYKYYKRSKERSTPFGLFSETSIGSFSST
                     EKLNLNGKTLKKVLLDSEWLIRLVFKIEKEYSRELAYKINPANYQFGDRVVQLFSINDT
                     KIEEVNIKFTKVYQLIDELCCDKYVYFNCIIEKLVESYGEEYRDIATSYIMSLIDSHFL
                     ISNINSELIMNFKFEEFISKVKEIDKQNLYYFKLIAISNLIVEYSELEIGDGIEKLKEI
                     YKLMSSLVETPNFLQIDLYNDGQIQLGNENKTQIVEFAEFLVSNSDHVKRTYLDDYKEK
                     FLDKYGVNREVQLMELFDSNLGIGSPYGYQHPKNDFWESSPSTVYFSEKEELEYLNNFE
                     KALETGGNIQLYNEEDFFNQDKDKINLGFELFFYVNKVDGKSVLSLTNTGCSKNLGASS
                     GRFSILSDKLEHYHQTITQIVENNNHVSGYNSCEITFLPENLRHANVMRTTNVREKVLS
                     LFTNMDKRSQILSDIYIGIDSKNSFYARNFKTKELLKFYSTNMYNQMMFSNELRFLCEI
                     AQEDHFGIFPWEMVYQKFSHIPRIVFKDIIVAPERWRLSGRMLSKDIHQIILENNLPTK
                     LYVDNSDNRILINRNNPLDNQLFEDIVRKSSNKNEELCLSECIFDSHLVEKESTTHISD
                     IVVPVFAKDEIKEPRYIKEILPEVIPTNVRQKIPFDEWLYFKLYMSADRQEEFLSDIMP
                     QILKLVNLDDGMSFYIRYTDPKFHIRLRIRTQNLYKSFEKIQEIFQLCIQNKLISNIDI
                     STYDREIERYGGLERIPLVEEIFCLDTEIVINSLSLIRQKRLDLTLDDLAIIFNYFYLK
                     SFFKDNNKEIIQFLEFACPEHLDSQNRDKNRNTALIDLYLIKGYLINLLPELSKLCQRL
                     KKLSDSCIQLSDDYTYIIYDSIIHVHNNRLFGIKRENETKIYAIIRGLIISEEFRNGHN
                     HG"
     aSDomain        complement(15358..15603)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_M5P35_RS04025_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.30E-08"
                     /identifier="RREFam001.1"
                     /label="M5P35_RS04025"
                     /locus_tag="M5P35_RS04025"
                     /protein_end="226"
                     /protein_start="144"
                     /score="25.6"
                     /tool="antismash"
                     /translation="PANYQFGDRVVQLFSINDTKIEEVNIKFTKVYQLIDELCCDKYVY
                     FNCIIEKLVESYGEEYRDIATSYIMSLIDSHFLISNI"
     gene            complement(16276..16446)
                     /locus_tag="M5P35_RS04030"
                     /old_locus_tag="M5P35_04030"
     CDS             complement(16276..16446)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001058290.1"
                     /locus_tag="M5P35_RS04030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_04030"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_249549472.1"
                     /sec_met_domain="TIGR03731 (E-value: 7.8e-21, bitscore:
                     67.3, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNEDFNLDLVTISKENNSGASPRVTSKSLCTPPGCKTGILMTCA
                     IKTATCGCHFG"
     CDS_motif       complement(16375..16446)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNNEDFNLDLVTISKENNSGASPR"
                     /locus_tag="M5P35_RS04030_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16276..16374)
                     /prepeptide="core"
                     /locus_tag="M5P35_RS04030_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="27.40"
                     /molecular_weight="3086.7"
                     /monoisotopic_mass="3084.5"
                     /core_sequence="VTSKSLCTPPGCKTGILMTCAIKTATCGCHFG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNNEDFNLDLVTISKENNSGASPR"
                     /leader_location="[16374:16446](-)"
                     /alternative_weights="3104.7"
                     /alternative_weights="3122.8"
                     /alternative_weights="3140.8"
     gene            complement(16795..17481)
                     /locus_tag="M5P35_RS04035"
                     /old_locus_tag="M5P35_04035"
     CDS             complement(16795..17481)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001033677.1"
                     /locus_tag="M5P35_RS04035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_04035"
                     /product="hypothetical protein"
                     /protein_id="WP_053861413.1"
                     /transl_table=11
                     /translation="MNKILKSELLKLKGSLTLNLILILSIIQLFTIPLYLQFTNNSVVI
                     ENIIFLPMLGYCILASIFSIFLHEQEEKANFFQNIKSEKNSGIIWGIKLISTDLLMVLL
                     GVPVWIVVGVEFNRLSYFAYVGVITWLLLVLLNHFHMLLSLITGKGGNLVISFIECLFI
                     IFATNKVFLNIFWLPIVLPVNMILEIGKNEIFMILVYLIGFIILSYFCNLAVMNNVEIQ
                     KICKKR"
     gene            complement(17459..18196)
                     /locus_tag="M5P35_RS04040"
                     /old_locus_tag="M5P35_04040"
     CDS             complement(17459..18196)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013851902.1"
                     /locus_tag="M5P35_RS04040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_04040"
                     /product="lantibiotic ABC transporter permease"
                     /protein_id="WP_029171580.1"
                     /transl_table=11
                     /translation="MTNIFKSEWLKQKSSSDKKLLILIPLLAIFIAFILAGPLNLESFS
                     IYWWEGGFLFTLLGLLFLADYSAEENAGAFQNISLGRYTFTIYLAKILLKFKDVLISTF
                     IFTIIFYGISFLFSGVISVDIGKDLICLLLIGVSSAWVLPLLYFLAKWINPYLLLATNS
                     LICLLVAPLIAQTSVWFIFPYTYHYKIAYALLHLKPSGDLEAALSGVEISTILISVSLS
                     ILVFVSFLSLLKWRIINEQNSKK"
     gene            complement(18189..18890)
                     /locus_tag="M5P35_RS04045"
                     /old_locus_tag="M5P35_04045"
     CDS             complement(18189..18890)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000452012.1"
                     /locus_tag="M5P35_RS04045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_04045"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_024383493.1"
                     /transl_table=11
                     /translation="MEVIIQNLRKSYKDKEVLKDVSFKIEEGTICGLLGVNGAGKSTIM
                     KILFGLERADSGEVIFNGKHKDIVEENRFDIGALIESPAIYLNLSAFDNLKTRALLHDI
                     PDERICEVLQLVGLSDTGKKKAGHFSLGMKQRLGLGMAIITNPDLLILDEPTNGLDPDG
                     IKELLNLIRDLKKSGMTVLLSSHQLSEVSKIADQIVILNQGKIFYDDINKNSNDLEKLF
                     FRIVHGGDGND"
     gene            complement(19062..20426)
                     /locus_tag="M5P35_RS04050"
                     /old_locus_tag="M5P35_04050"
     CDS             complement(19062..20426)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677618.1"
                     /locus_tag="M5P35_RS04050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_04050"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_053861412.1"
                     /transl_table=11
                     /translation="MMKRYSINKRILRTVLEIVIGTVANVIMLLVLSYVLIFTGQLNTY
                     GTDYHISISDSKSANGIKNQMDYSVFDYVLFDSDNGELVSGKYQKQDLQHYKEVFDTGS
                     SVSEGSILFTEYENSDFILVIRRPTVPEFVNQNFRHISYNLVSYLFFIVLELLLISISV
                     IRLLREFTKNFRLIEKISLNMGIPGMDIGRKETEILECNNILLTLYQKDEELTKLLEME
                     KKDKEDLSFQVAALAHDIKTPLTVLKGNIELLEMTNLDEKQLDFMSSINHSVGIFEKYF
                     NSMVNYSRLLIEDKNYQEDIELAKFLDELSLECRDIMSSKKINFQIVNESHTRVIKGNR
                     LNLDRALINILSNATRFCSEEGKVVLTISESSNFISFEIWNNGLPFTEESLKDGGKLFY
                     TDNKGRNDKHYGIGLSFAQKIAMRHQGQLILSNPQNGGAQVTLLIKKILRAGQKA"
     gene            complement(20404..21102)
                     /locus_tag="M5P35_RS04055"
                     /old_locus_tag="M5P35_04055"
     CDS             complement(20404..21102)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000276750.1"
                     /locus_tag="M5P35_RS04055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_04055"
                     /product="response regulator transcription factor"
                     /protein_id="WP_002943322.1"
                     /transl_table=11
                     /translation="MYKILVVDDDFEIVKLMRTILEMKNYNVTTYQEVRLPIKISDFDG
                     FDLILLDVMMPNVDGLQICKQIRKSVSSPIIFVSAKDSEDDIVSGLNLGGDDYITKPFS
                     VNQLVAKVAAHLKREERYRNAESNESVIRELLPLTFYLQEKLVCVNGEAISLTKREYDI
                     LELLSSKTNKVYTREEIYECVYDDEADALFRSISEYIYQIRVKFGSYGINPIKTIRGMG
                     YKWNDEKIFN"
     gene            complement(21143..22516)
                     /locus_tag="M5P35_RS04060"
                     /old_locus_tag="M5P35_04060"
     CDS             complement(21143..22516)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000719507.1"
                     /locus_tag="M5P35_RS04060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_04060"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_000719507.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 4.1e-38, bitscore:
                     124.7, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIGLLSNVFISLFIVILASGSVSSGVSANENKEISYNVLVSEN
                     KSIEDVEDVLQSQGIKVTDKIPEINFLTISTEKSEDTIKKENSNYIDDIVIDNTMTVKP
                     NITYLYGDKVYTNTNLDFWGNQWDMQKSISTGSKFQHKSSGKATIGVIDSGITYDNPDI
                     YSHIISVQNFTSDLETGIVDNQNVVDKIGHGTSVVGQISSSGEYLGIAPDMKIRMYRVF
                     DEGNAQDQWILKALIQAAKDDVDVINLSLGEYLLRDSTDEDDDTALINIYQRAINYAHN
                     QGSVVVASVGDEGMDLQNQDELKNYLGSLRGKDYSQVDGTVQDIPAELDNVVTVGSVDD
                     NDLVSSFSNQGNGDIDIYATGGGSQALSKVGYDKWVADKLYEKEWILVPTLEGKYTYAY
                     GTSISTPKVSAALGLIIEKYNLKDQPDEAIRILYDNCFLSNNGNNGQIRLLNITNFVQ"
     gene            complement(22613..24496)
                     /locus_tag="M5P35_RS04065"
                     /old_locus_tag="M5P35_04065"
     CDS             complement(22613..24496)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000261812.1"
                     /locus_tag="M5P35_RS04065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_04065"
                     /product="SAG1250 family conjugative relaxase"
                     /protein_id="WP_249549473.1"
                     /transl_table=11
                     /translation="MVVTKHFAVHGNKYRKSLIKYILNPAKTDQLKLVSDFGMSNYLDF
                     PNYEEIVEMYQANFVNNDRLYDSRNDRQQIKQNKIHAHHLIQSFSPEDNLTPEEINRIG
                     YETIKELTGGNFRFIVTTHTDRLHVHNHILINSVDLNSHKKLKWDYAQERNLRMISDRL
                     SKEAGAKIITPNRYSHEKFVTYRKSNHKFELKQRLYFLMENSKDFDDFLSKAEALNVQI
                     DFSRKYARFLMTDMPMKRVIRGKQLDKRQPYTEEYFREHFAKRAIEQCLDFLLPRVRDL
                     SQLLEFARELNLAMSLKQKNVAFTLTKNSQSITVNNQKVSSKNLYDVQFFETYFEKRGE
                     VPDIDQSQLISDFEGYCEEQDKEKLAYEDLQEAYQAFKEKRDQVQEFDVVLADHQIDKL
                     VKDGLFIRMNYGVKKDGLVFIPNRHLDIKETESGKHYHAFIRETAQFFIYNKEASELNR
                     YMRGRELIRQLTNDSQTISKRKRPTIDTLKKKIEEINLLIELGTENKSYQDFKDEIIKD
                     IAQLDLTITEIQEHIDHLNKVAEVLLNLDNNDIENRRLAKYDYAKMNLTAAIKLEQVEK
                     EIEIYQIKLDKSIDDYEYLIRRLEKFVKILNEIDSSKDELKFEHSEKNVKE"
     gene            complement(24483..24848)
                     /locus_tag="M5P35_RS04070"
                     /old_locus_tag="M5P35_04070"
     CDS             complement(24483..24848)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000263054.1"
                     /locus_tag="M5P35_RS04070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_04070"
                     /product="MobC family plasmid mobilization relaxosome
                     protein"
                     /protein_id="WP_000431640.1"
                     /transl_table=11
                     /translation="MENRYRTNLKKVFLTDQELANLNNHISQSSCQNFSAYARKVLLNP
                     NMTFLTIDTSNYQDLVFELRRIGNNINQIAKTVNQTKLLTVEQRDNLKTGIGQLIAEVD
                     KDFYVKCQKLREFYGSH"
     gene            complement(24851..25213)
                     /locus_tag="M5P35_RS04075"
                     /old_locus_tag="M5P35_04075"
     CDS             complement(24851..25213)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013851909.1"
                     /locus_tag="M5P35_RS04075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M5P35_04075"
                     /product="SAG1252 family conjugative relaxosome accessory
                     protein"
                     /protein_id="WP_000140674.1"
                     /transl_table=11
                     /translation="MTESYRTIRKEINLTLEEFEQIQLLMRKENAEQFSPFVRQKLLDI
                     VNNKDDIRDWFILWQSQKIEQISRDILQVATLAERGHQVTSEHLRIILTCVQELMTEVE
                     KAVPLSSEFRDKYMGG"
     misc_feature    complement(25321..25335)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 19.31"
                     /tool="antismash"
ORIGIN
        1 caattcaaat ggagtatgaa cataagtcaa gcctgtttca aagacaacat tgccttcgta
       61 gtccaacaaa ccatcataag tagtgataat acttgaattg acaaattttt cgaggaaata
      121 aatagttgct ccatcccatg tctccacaaa ccgatcaaaa tcttctttat tttcgatttt
      181 gaagacacct gatgctccaa caccgttgtc tggtttagca atcattggaa aaccaacatt
      241 cttcaaagct ctgccaaaat cacgttccga tttaacaacc acacctggaa caactggaac
      301 acctgctttt ttgaaatatt ttttcatttc agacttaaat ttggtctttt tcaggtgttt
      361 aggcttagca ccaaaaatgt tgaattgttc acggagggct gcatcgtttt caagccaata
      421 ttcattgtgg gattctacac ggttaattgg accatgcttg taaataagaa aggctgctgc
      481 acgcttgact tcatccaagt tttcaagatt ctcaacacgg aagtattctg ttaaggcatt
      541 acgaagttct tcagggaatt gatcgtaagg ttcttgcccg atacctagaa ccgtaacgcc
      601 ttcttttttt gccaattcaa tggtaaatgg ttggaaattt tctggataaa aaggtgaaat
      661 aacgagataa ttcataggta gtcctttcta gcttatagtc cgatagaatg aaggaagaat
      721 ggcatttgct ttctccacca cacccagtcg tgggccacat ctgttcccca agtatcaaac
      781 caagctggga tactcttctc ttcaaatgca cgtttgaggt tatagaatga gtccaaaccg
      841 tcttgctccc aatcgcccaa acctgtacag acgataatat cagcctgacg gtatttatca
      901 ataaaccagc cgtcgttttg gttccaaatg taatctgatg gtgagttctg ataaacaaca
      961 tcatcattgc cataatcttg attgttgttg aagaaacgag catcatagac acctgaaagg
     1021 gcgataactt tcgtgaaaac atctggatgt tgcaggaaga aattgagcgc gtgataagct
     1081 cccatagaac aaccagttgt catcatccca tcaaaccaac cagttttatg tttgataaag
     1141 ggaatcgctt cttcaatcac ataacgctca taggcacggt gagcctctgc cttgtcatgg
     1201 atggatttcc agtctgccaa ccagctttca ctatcgtagc tagttagagt aaaaaattgg
     1261 acctgacaag cttcaatcat accaaaatca gcatattcat tgtaagaacc acctgatgaa
     1321 gcaaatacga caacaggaat ccctgcgtga ccataacgat ttagattcat ttctcggcca
     1381 agatttccag accaatgact taaaaattca acgtgcatag taaagcctcc tatttgtata
     1441 tttttgtttt atgaccaatg ttcgcttagg aatcgtaggc aagctggcaa atagagcgcc
     1501 caagcctctt cattatggac cgcacctgaa acgacttcca aggcgatatt gtccaaatcc
     1561 actccgccag cgatcaattg acgatagtaa gtcaatgaag aattgatata ggcctgcttg
     1621 atatttcctg ccatcaatgt tttatctgta tcatctgctt cttctgtccc aacgtagatg
     1681 tagactcgtt gctctgagtc taattgttga cgttcaatat aacggtcgaa agcatcttga
     1741 tgaagccagt tggcagatga aaatactcct agacagccaa tctggttctg ataagccaat
     1801 cccataaact gggtgatatt gcctcccaag gatgagccaa tcattgcagt gtgaacttta
     1861 tcagattttg tccggtattc ttgatcaata aatggtttga cgacatccat cacaaattca
     1921 gcatacaagg ttcccttacc accgaactgc acaccaggaa tccccatctc actaaacttc
     1981 caagcagcgt attcatgcat gcgatcagca ccatcgttat caatagccac tacgatcatt
     2041 tttgcaatgt ctggattacg cttaatagtt gggatgactt tccatgaatg acctgaaaaa
     2101 gcttccttac tgtagagtac attttgccca tcgtggaaat aaacaacggg ataggtctct
     2161 tctgtatttt cagcatatcc tttcggcaat aaaacacgga ctcgacgttt tctttctgta
     2221 aatggtacat ctaattcatg agttctcatg tccaaataaa agtaagactt attcatatct
     2281 atctcttcct tacgtatttt aagtattata tcatagtttt tctggaatat tcagaaaatt
     2341 tagttattta tttgcaattt tcggattttc cgaacatagt tagttaatgt cacagaattt
     2401 tctcaaacat ttggcggtaa tgctccaatt ctttttcttc ttgttgtgtg atgtcttcaa
     2461 aaatatctag caaaatagta cctttatctc gtttccaggt tgccacaaat cgccctttat
     2521 aaaatacaac aggtttgaca atacctgtca acgtataaat gttacggatg tattttggat
     2581 cgaaaaatgg gttgtttttc ttttcatagc ccaaaagtaa ttgatcaaac ccagcaacga
     2641 aaagacactg aggtaaatct gcctcatcaa gcaccccaag gtaaaaccgc tcctctccag
     2701 ctacttgaat tgtttttaaa tctaattgag ccatccactc tagaatggtt gacttatttt
     2761 ctttgaaata ataacgagca tctgctagac tgactggccc aaagcctgaa aaataccgac
     2821 gtgctatttc cagctcagct ttttcccgag aaagtggctg aaagtctgtc agacgatgaa
     2881 aacgcttggc accgtactct tggtagactt ccccacgctc gaccatgtag cgaaagagac
     2941 cgccccaggc attaaagacc agcttctcct ctttctgtgt catcttttcc tctcggcaaa
     3001 ggaccttgag atcctcacgg gtcataggac cttgttcaag ggcttctaaa atcagatggt
     3061 gatatttctg cttggtctga ggactaaaac cgtcccgtcc ttctgtcttg aggtaatcgg
     3121 tgctgaccag ccgcccctca tggatataga gaggaatttc cgactcgaga taggcatgaa
     3181 ccgttcgccg aatggaccac tgacgagtca gttcctcctg ccagctaccc tcatgaaaat
     3241 cctccgctgt catacggtta cgaaatccga catgaacata gggctgaaac tgagcctgca
     3301 aaccattgag attttggcag atttgttgaa cagactgggg gttcaacaga ccttgtttct
     3361 gcagaataat tcccttccaa gtattgtggt gcatcgtatt tctcctccgc tttctaatcc
     3421 cagtataaca caaaagacac ccgaaggtgt cctgtacatt atgctttcac aatgggaatc
     3481 cagagttcca tttggtagtc tggggaactc atgtctcctt caaaatagta ctcaaaatct
     3541 ggtgcacctg aatggcgata gccgtgttca ggaaaaaaag tttctagcgc ataacgccat
     3601 cctgcatgaa tagattgagg aacagggcct gttagggtaa aaatagcata gtcagcttcg
     3661 tgaacatcaa gaagttctaa gcctaactta gtcgcttttt cactatctgt gacatcataa
     3721 gcagccatat aattaatcgt ctcgtccgct tgagctaatg tacaaactcc aaaggactgc
     3781 ccacttccta gagcagctaa ctcttcataa gtatggttct tgaacaagtc ttcccatacc
     3841 tgcggacaca cttcgttact gattgctgtg cgaagaagtc cagcaactgt aaaaccagcc
     3901 ttcttttcaa tacgaacatc catttcttta cctccttgga tggttaatga tagttgcaag
     3961 ggtaagagga ccttaaaagg caacccctta cgcacttgac taggagaaat ctgatgaaat
     4021 tgtttgaagg caaaggcaaa agaatccgaa gattcatacc catatttaag ggctatatct
     4081 ataatctttg cctgtccttc acgaatgtcc atagcagctc gcgtcaactt tcgtaaccga
     4141 acgtattctg acaaggacat atctgtcaga atcgaaaaga gacgactaaa catgggaacg
     4201 gaatatcctg atatgcgcaa aaattcccgt tcatcgattt cgctttctaa aaggactcta
     4261 ggtaacgtac ggttgcattg aactctttta tcatcaactt cccctttccc tatcagttta
     4321 ccatctacca tccaagtttt cccgatactt ttcgtcggaa aactatcggc ttaaaccgtc
     4381 aaaaactctt ccaagtcctt gagggaacgc tctgctattg cctcataacg ctccttctta
     4441 tcgcggatac gcggtccgtc cagctccttg atgataccaa agttgacatt cataggctgg
     4501 aagtgcttgc tttcggtgtg ggtgatgtaa aatggcagag ctccgatggc tgtggtctgt
     4561 gggaagatga ctggctcttc gccatggaaa cggcgaacag cattgatacc ggctactaag
     4621 ccagaggcgg cagactcgac atagccttct actcctgtca tttgacctgc aaagaacaaa
     4681 tttggatttt tcttggtcgc aaaggtctgt tccaataagt ttggcgaatc catgtaggaa
     4741 ttgcggtgca taacgccgta gcggacaaac tcagcatttt cgagtcctgg aatcatctgg
     4801 aagacccgct tctgctcgcc ccacttaagg tgagtctgga agccaacaat attgtaaagg
     4861 ctacctgctg cgttatcctg acggagctgg acaactgcgt aaggtgtctt gtattcgcca
     4921 tcacgtggtc ccttgtaatc ttctggatat tccagaccaa ctggcttcat tgggccatag
     4981 agcatggttt tgataccacg tttggccatg acttcaatgg gcatacagcc ttcaaagtat
     5041 ttttcttttt caaaggagtt aagcggtgct tcctcggctg aaatcaaggc ctcatagaaa
     5101 gcgttgaact gctccttgtt cataggggca ttgagatagg cagcctctcc cttgtcgtaa
     5161 cgagacttaa gataaaccaa gtccatgtta atggtcgagc tgtcgacaat cggtgctgcc
     5221 gcatcgtaga agtaaaaacc gtcaccacca ttaagcgcgt gaatcttctc cgccaaggcg
     5281 tcagacgtca aaggccccgt cgcaatgact gtaatagcat cttcaggaat ttcggtaatc
     5341 tcaccacgga tgacctcaat cagcgggtga ttgtgaatct catcagtaac cgcttgagag
     5401 aaattctcac gatccatggc catggcacct ccagcaggaa cacggtgagc ctctccagta
     5461 cgcatgataa tggaatccaa acgacgcatc tcttccttaa gaaggccgac agcgttggtc
     5521 aaactatcac cacggaatga attggaacaa accaactccg caaacttgtc cgtcttgtgc
     5581 tgaggagtcg gcttgacacc acgcatctcg tagagtttga caggaatgcc acgtttggca
     5641 atctgataag cagcttctga gccagccaag ccagctccta taacattaat gtgggtttga
     5701 gacatgaaac taatacctct agccagaata tctgactact gtttgggaat acccaaaaac
     5761 agaacctttc taaattttat acctatctag tataccagaa aatggctaga aaggacaaaa
     5821 ctaccttcat tgaaatgaaa gtagtttcac ctttttacat aatatatttt atgtatatcc
     5881 tttactgttc tatcgcttat ttacaatagc tccgctatat ctccaacaac ctcaaaattc
     5941 caaccaagtc tcctataaga gtcgatttct tcctgactat acgggaaagt attcagcaaa
     6001 atggaatcca ttcccaattc atgagcaata gctatatcgg atgtcaaatc attaccaacc
     6061 ataaccgttt cctcaacatc aagattattt tcctctaaaa ccagttgaag aaatgctggt
     6121 tcaggcttct tcatcttaaa gtcagaagag atataaattt tttccatcaa atcagcacaa
     6181 cctgtctgtt caatttctgc ctgagtaaaa attcgttgag cattggagag aataaataat
     6241 cgcacttctc tgtcctttaa tgtctgtaga ctagttaggg tattttcata agcctctaac
     6301 ttttcacgtg aaaaagcacg cggaaaatcg tggctactac ttgtccaaaa gtctctaaat
     6361 cagtcggctt attggtactt tggttttcat ttggtgcatc cgttaataga cgaatgaaga
     6421 ttgtttctaa atcaatttcg acatactgat aactcactgt ttccgcgaga gagctctctg
     6481 cctcttctac aaaacgatga taggcatttt tcaactggcg cggtcgatag gaacaaccaa
     6541 aagcattgta aatctgtgtt agctgattcc agacctctag tttattctca tctgtacgaa
     6601 tatcaaccaa tgtaccataa aaatcgaaga tatagttttt gtaacttttc atgtctttct
     6661 cctaatcttt agacatcatt ttttatatta taccccacaa cgaaaacgtt tgcaacaata
     6721 gaacgaaaaa acctaccaca ttaagtgata ggtttttatt ttgattggaa actctattat
     6781 ttaagagtaa caattgcaca acctgttaaa tgtgcagtat caaggggttt gagttcttaa
     6841 tttgaagttt ggcaggaatt ttggcataaa attgaatcca atcctgcact tttaatattt
     6901 tgagtgattt cttcagaaac tgttttatct aaagcattaa accagtgact gtatgtattc
     6961 aaagttgttg atttatcggc atgtcccata cgtctggcta catataaaat atcttttttc
     7021 aagacattga ttagatagga tgcatggcta tgtctgagac cttttcctgt aattactgga
     7081 actcctacct gctgagcttt ccgtttgata atgcgacaaa tggttgattt acaaaaagga
     7141 tctccaaatc ttgaaatgat aaaatctgta tcttgatttg caaactgatt ttttcgccaa
     7201 acttgaagta cttcaatagt tatatcatcc aattcaataa gtcgttcacc tgctggagtc
     7261 tttgtttggt ctttacgata ccaatttcca ttttcatctt tctccaaggt tgtatgtacc
     7321 tttagaaatt tattttcaaa atcaatatcc tcccaacata aagataaacc ttcactcact
     7381 cgtacacctg tcatataata taaccagatg gctgtaaatc gttgtaattc ttcataatca
     7441 tttaagtcaa atgatttgat aaatgtctga aactccgcat aggtccaaaa tggagtttct
     7501 ggatgcttac ctctaggatt atctaatgct ttacaaggca tatctgaaat atagccaagt
     7561 ctttctgcat aacccataca agctttaaac cttgaccata aatttttcgc atagttttca
     7621 gaataatttt ctatgatatg caatctaaaa gcttcgcaat ctctaggagt tattgctttt
     7681 aatagctttg aaccaaaata ttgaataaaa agtttatgat gaggaagagc cgtcttatat
     7741 gtcacagact gaactttttg cttataagct cttaaataaa ttgtgttcat atagttttca
     7801 aaagtcatat tgtaattttc taaactgact ttgttggcaa attcatattt tatacgaact
     7861 aattcgtcat atgcttcttt cattgtttca aaggttttac catattgatt ttttctagct
     7921 ttcttttgta cccttttgcc agttactggg tcgattccaa gatcaatctg ataaaatatc
     7981 tttcccttat tatcacaata aacacctttg tattttttac tactttttgt tgccatttgg
     8041 attctcactt tctaaatgtt atttagatag tggaatccct attaattgtt ccacaatttc
     8101 tgctggtgcg atacctagtc ttcgattgtc aaagggcgat ttacttaatt gtaccgcatt
     8161 atggtcaact ttgcgagctt cttcaaactt ttttacagca attcttttag cttctcgaat
     8221 aatgtctcta gaggtatgtt caggaaatcc taagttcatt aaatctttat atgtagcagt
     8281 tctcatacac tttcctcctt caaatcactt agttttttaa catgctagat gagatttgaa
     8341 tggttagttc aatcatggga atttcacccg ctgtcctttt acgatggcag cctgaacggt
     8401 cagaagtatc attatcatta tttgtgtcat ggcagatagg tcaccatcct atttttgaat
     8461 aaatgatttt cgctcatttc ttggcgcatt acattctatt gctcaacaaa taaataaagt
     8521 cccacctaga attattcaat tgtcaaaggg caaaaagaga ctaaaaattc ctctcactat
     8581 aaagagtgaa ttttttagtc tcctgtttcc ttatttttca aaaaattttc gtaggttgtc
     8641 caaaattgta tttctcatcc gaaatagact agtcgcagac atctcatgct ctattgctac
     8701 ttctctgatg gtatgctctc taaaatacag agcatcaatg attttaaact ctttatcaga
     8761 taaggttaat aaagcctcat ttagttgctc aataaggagc ttgttttcta taaaacgttc
     8821 aacatcaaca gttgtatcag gcagtacatt tgctagcagt aacccatcta cttcaaatga
     8881 tgaaaaaggt aatactccaa atttcctatc ttttctattc agatacttct cgtgattgac
     8941 caattgccag tagcttttat aaaccgtttc tgttacgggg attttactac ctctaacgtg
     9001 aatataatat ttcatttcag cctccgttta tgattttttc ttagtcataa aaggagggct
     9061 ccttatctca accatagcta tttctcactt ttatcaaatc aaggagttct cctcactata
     9121 agagtgaaaa tatggtgctc ttgttccaaa aaaaattata tgtaccaaaa aacagcaagc
     9181 tcttctgaac ttgctgatct atattttaat aagtttctgt ttagtaggta acaacaagat
     9241 attttgctat ataagcaatg taatacctag ataatctata atttattcta tgcgcgctat
     9301 tctaaattca ttattaatct caacagctat ggttccttct tctgctaaca aataaacttc
     9361 tccgtaatcc caaacttctc ttttttcatt agaattagaa ccagaataat ctattttatt
     9421 tagttccgat ttagaaattt cttgtcccgt attcaaaata aatgtttttg aatctgctat
     9481 tactcctaga aattctttta gtttatcatc agatacaata tcagatgaaa tacgaaattt
     9541 tttattatta aatttaacta tcctacaatc agatggatca attgcaagtt ccccacctgc
     9601 tgaattatta ttgaactctt ccaagctcag catttcatta ttggattgca catccgaact
     9661 caaagaaacc ttataataag aatcatttat agaaatagct aaaccatcac taaaattata
     9721 gagcccacta tatgctaatg atactgtatc actattactt ttagtaacaa ctttctggct
     9781 atttctatca attactaatg ttttaaaaaa agattccttc acagtaccta gatcattttc
     9841 atcaacaatt tgattcatga ttgtataatc atttccttta tatgtaaatt gattaaatga
     9901 ttgatcatga aactctattg ttttattgtc taccaatcta catgcaacta aagtacaaat
     9961 tccaataaga acaactaagc taaataaaat tttcctcatg ctacttcacc tcctttataa
    10021 catcatcaaa taataagagt gccctttgcc aatttgttgt aacctttaag ttatttagtt
    10081 cgatcattgt taacagaatt ccaattattc catctaaata accaagatta tcttttgttt
    10141 ttatattttc aaattccgcg gtagtattaa aaccatatgt catgtcttct ctaaaatcac
    10201 taattaactt ttccttaaga gattttatac agtcatcaaa atcagttgtt ttataaattt
    10261 ttttaaaaaa taggcaaatc tcaattgctc cagaaaatcc gtgacataaa atagattgtt
    10321 ccaaaccatt acttctcctg atggatgctt tcaagatgtt acaagcttta gattttagtt
    10381 tcttatcttc tagagccaaa cttgaataca gatatagtaa actaattcct gggctaccgt
    10441 agcaccacgc atctcgaata aattcatact gtaaattgct tttttctgtt ttctttagtt
    10501 caatatcgct taatccctct ttccacatat aattttttaa ctcgtgtttt tcgtataaca
    10561 ttataatttt tttgattgct gcaatagatt tttcattaga atagcctttt aattttgaat
    10621 aagacaacat tgcgccaaca cccgcaaggc cgtgtgctaa accaaaattt agacatccta
    10681 acggataaag cttagactct gtcttggaca tttgattctt tgattccaca tagaagcctg
    10741 ttaaagtaga attttttagt gaaaactcag ataagaaatt gataattctg tttattatat
    10801 aatcattttc atcttgctcc tgagataaaa gataaactaa tactccagat actccttcta
    10861 tgatgtcata atctgtagga gagattttct taatatctat attttcaatc ttacttaacg
    10921 tatagtactt aatgtactca ttaaaactaa tcaataagtt atgatattct gggtgttctt
    10981 caactaaatg aagtatactt attccaattc cagaaactcc tgaaaataaa gaatccgata
    11041 aaacaccata atttctcatt tgtttaacca taaagttaac atatttaccc gttctagcgg
    11101 agtattttct ttcactagtt aaacttgtca attctgaaga taataatatc aatccaggta
    11161 aaccagaaga caaggtcaat aaatcataat tcggttgttc agcatatctt tttaactgct
    11221 catcaaattt agcaaatact ttctcagata aatcaataat aactttattt tcatccatca
    11281 gactcctcct cgtacttttc tgaatagtaa agttccctat aatatttaga tttacttata
    11341 aggtcgtcat gttttccttc atcaataatt cgtccatctt gcataactat aattcgatct
    11401 gctctactcg cagccattag attatgtgac acaaacaaag caatcttatc tctagaacga
    11461 gttacaaatt catcaaatat ttctttctct gaaacaggat caagcgctga acttggttca
    11521 tccaaaatgt atatgcttgc attcttgaag aaagtcctag ccaatgctac tttttgccat
    11581 tgtcctcctg aaatttgtct actatcgtta aaccaggtcc ctaaacgttg attaaggttg
    11641 aaattgtttt ctgcggttaa gaaatttaat tttaagttat caatatgttt ctttattttg
    11701 gagtcagata tactgtttac atcacttagg ccaatatttt ctctcacaga taattcaaac
    11761 ttcacaaagt cctgaaaaag aacagaaaca ttattttgat aataactcaa gtctaggaca
    11821 tcactagatt cgttattata atatatttga ccctctgaag gttggtataa tcccgatagt
    11881 aattttacta aggtactctt accagaacca ttcttcccca caattgctac aagttcaccc
    11941 ttattaaact caacattaat atcctctaaa gtttttttga cacttcctgg atagataaaa
    12001 gagagattat tgacttttat tttgtcaatg cgcttttcaa ttcttgagat tctactattc
    12061 tgaattgaaa tattacttac ttccatatca aaaaatttaa ataattgttc catgaataaa
    12121 cttgtgttat agatgatata agtattttgg atcatagatt gtgagtaggt atttacacga
    12181 gttattgctt gaataaggct tacaaaatta cctactaaaa gtttaccgct tcgaattgac
    12241 tgtatcatca taaaaatagc tataccatta ataaaattca ataaaatatc caaacttcct
    12301 ctgaaaagaa ctttcttttt cgaaatattc aaatcctgat tcataaaatt tcttttcaat
    12361 gttccatatt tatcaatgaa atattgacta ataccattta gtttaatctc tttaaatgaa
    12421 aaatcatgag taagaagata attgatgtac caaacttccc tctccgaatt tgctcgctcc
    12481 cattgaatca aaaattctag ctggccaaca cgcataaaaa ttactaagga aataacagga
    12541 attatcagta aaaaagtcga tactgccaca ttccaagtgg acacataaat aatacttgtt
    12601 aataaagata gaaaccctgt aatcacacca atgatagcat tgaaaagttg gaacggctta
    12661 tatgtactat cttgtacaat attttcaatg agattgtatg tatctgcttg ttcaaaatct
    12721 attaaattta gagatgatgt ttttttcaat aacttcaaat tgagattata ggacaagttc
    12781 atattaaatt tctcacttat atatgagttt aactgactta gtattgatag catcatttgc
    12841 attaatatat agacaattaa tactgaaaaa atgttacttc ctttttttaa aacagcattg
    12901 attaattctt gatagataaa taagcttgct aaaggaatta ttgattgtaa tatgtttaaa
    12961 attattagat agctagcata ttttctttct attcgaaaaa ttaatcttat tgttttagga
    13021 attgtcaaaa ttgtttgaaa aaaatttttt agtgtaaatt tatccatgat tgtgcccatt
    13081 tctaaattct tcactgatta tcaatccgcg aattatagca taaatcttag tctcattttc
    13141 tctctttata ccaaataagc gattattgtg tacatgaatg atactatcat aaatgatata
    13201 tgtatagtca tctgataatt gaatacaact gtctgataat ttcttaagtc tttgacatag
    13261 tttagatagt tctggaagaa gatttattaa atatcccttt attaagtaca aatcaattaa
    13321 tgcagtattc ctatttttat ctctattttg gctgtctaaa tgctctggac aagcaaattc
    13381 taaaaattgt attatttctt tattgttatc tttaaaaaat gatttgagat aaaagtagtt
    13441 aaatattatt gctaaatcat ctagggttaa atctaatctt ttctgccgaa ttaaacttaa
    13501 tgaattgatg actatttcag tatctagaca aaaaatttct tctaccaaag gaattctttc
    13561 tagtccccca tacctttcga tttctctgtc atacgttgaa atatctatat ttgatattaa
    13621 cttgttttgt atgcagagtt gaaaaatctc ttgaattttt tcaaaacttt tatataaatt
    13681 ctgcgttctt atccttagtc ggatatgaaa ttttggatca gtatatctga tatagaagct
    13741 catcccatca tctaaattta ctaacttcaa aatttgaggc attatatccg aaagaaattc
    13801 ctcttgccta tctgccgaca tatacaattt aaagtagagc cattcatcaa atggtatttt
    13861 ctgtctaaca tttgtcggaa taacctctgg taatatttct tttatgtacc taggttcctt
    13921 aatttcatcc ttagcaaata ctggaacaac tatatcagaa atatgagttg tagattcctt
    13981 ctctacaagg tgtgaatcaa aaatacactc tgatagacat aattcttcat ttttattact
    14041 actttttctt acaatatctt caaaaagttg attatctagt ggattattac ggttaattaa
    14101 tattcgatta tcactgttat caacatacaa ttttgtcgga agattgtttt caagaataat
    14161 ctgatgaata tccttcgaca acatccttcc actaagcctc caacgttcag gagcaacaat
    14221 aatgtcctta aatactattc taggaatatg agaaaatttt tgataaacca tctcccaagg
    14281 gaatattccg aaatgatctt cttgagctat ctcacataaa aaccgtaatt cattgctaaa
    14341 catcatttgg ttatacatat ttgtactata aaattttaag agttccttag ttttaaaatt
    14401 tctagcataa aaactattct tagaatcaat accaatatat atatcagata aaatttgact
    14461 tctcttatcc atattcgtaa aaagtgataa tactttttct ctgacatttg ttgtgcgcat
    14521 aacattagca tgacgaagat tctctggtaa aaatgttatt tcacaagagt tataccctga
    14581 tacgtgatta ttgttttcaa caatttgagt gatagtttga tgataatgtt ccaacttatc
    14641 tgatagaata gaaaacctgc ctgagctagc tcctaaattc ttagaacatc ctgtattagt
    14701 taagcttagt acgcttttac catctacttt attaacataa aagaacaact caaatcctag
    14761 attgatttta tctttgtctt gattaaaaaa atcttcttca ttataaagtt gaatatttcc
    14821 acctgtttct aaggcttttt caaaattatt gagatattct aattcttctt tttcactaaa
    14881 atatacagta gaaggcgaag attcccagaa atcatttttg gggtgctgat atccatatgg
    14941 agaaccaatt cctaaattag aatcaaacaa ctccatcaac tgaacttctc tatttactcc
    15001 gtacttatct aaaaattttt ctttataatc atctaaataa gtacgcttta catgatctga
    15061 attacttact agaaactcag caaattctac tatctgagtt ttattttcat tacctaattg
    15121 gatttgacca tcattataaa gatcaatttg aagaaaatta ggggtttcaa ctaacgatga
    15181 cattaacttg tagatttctt taagcttttc aatcccatcc ccaatttcca attcagaata
    15241 ttcaacaatt aagttgctaa ttgctattag tttaaaataa taaagatttt gcttatcgat
    15301 ttctttgact ttagaaatga attcttcaaa cttaaaattc attattaatt ctgaattaat
    15361 atttgaaatt agaaaatgac tatcaatcaa actcatgata tatgatgttg caatatctcg
    15421 atactcttca ccataggatt caacaagttt ttctataata cagttaaaat atacatattt
    15481 atcacaacaa agctcatcaa taagttgata aactttagtg aactttatgt tgacttcttc
    15541 aattttagta tcatttatag aaaacaattg aacaactcta tctccaaatt gatagttggc
    15601 tggatttatt ttataggcta attctcgaga atattccttc tcaatcttaa aaactagacg
    15661 tattaaccac tctgaatcca agagtacttt ttttaatgtt tttccattca agtttaattt
    15721 ctctgtagaa gaaaatgaac ctattgaagt ttcactaaat aaaccaaatg gtgttgagcg
    15781 ctccttgcta cgcttataat atttatatac agattctgat aattggttga tttttttcct
    15841 tttcattgaa tcaccactat aatatttttg aagcgattca tataaactcc tgctggctac
    15901 aaatagttgc tcctggaata tcttattctc tcttatagtt tctaaaaatg aattataatc
    15961 acattccaac aattcatgta ttccaatgat tgcattacga accaaaaaat tatttgtagt
    16021 atatttatgt tccattagca gctccaactt ctaaattatt tttataaatc ttcaaatatt
    16081 attttggaaa tttataaaaa taaaggtagt agactactat ccactacctt tattttagca
    16141 atagacatat tcgtctaaag agtaatatcc taaacaaata ttctaatatt tagagggacc
    16201 ttactcgaaa agatatagag tccctttctt tcttagtcaa gatttgcaaa aagatagtta
    16261 ctaaacaaat aaattttatc caaaatggca accacaagtt gcagttttga ttgcacaggt
    16321 catcaaaata cccgtcttac atccaggagg agtacataat gatttactag ttacccgagg
    16381 tgaagctcct gagttgtttt cctttgagat tgtgacaaga tccaaattaa aatcttcatt
    16441 gttcataata aaattcctcc aattattttt tctttgttcg aacaaatata ttgtaagata
    16501 cctagttcag aatttgttca taattataga gaatgaacaa atttttttat ttagaatgca
    16561 tgaaatattt atactgatac tctggacaat taaataaaaa gatagttgac taatgaaact
    16621 gctgaaaaag tctgatattt ttaaaatatc atgaacaata ctgtcttgaa aagataataa
    16681 aatagacata aaaagcggat gacctgcaat ctttagattt caaaatatgc tgtcattcgc
    16741 tttttatcta ttgaattttg ttgtattcta ctcttttagt gacctctaac caatttacct
    16801 ctttttacat attttttgaa tttcaacatt attcataaca gctaaattac aaaaatacga
    16861 taatatgata aaaccaatta agtatactag aatcataaaa atttcatttt tcccaatttc
    16921 taggatcata ttaacaggta aaacgatagg caaccagaag atatttaaaa atactttatt
    16981 ggttgcaaat ataataaaca gacattcgat aaaagaaatt actagattcc ctccctttcc
    17041 cgtgataaga ctaagtaaca tatggaaatg gttaagtaat actaataata accaagtaat
    17101 cacaccaaca tacgcaaagt aagagagtct attaaattca actcctacca ctatccaaac
    17161 tggaactccc aataaaacca taagtaagtc tgtcgaaata agctttattc cccaaataat
    17221 tccactattt ttttcgcttt ttatattttg aaagaaattt gctttttcct cttgttcatg
    17281 aagaaaaata gagaaaattg atgctaatat acaatatcct aacataggta aaaaaatgat
    17341 attttcaatt acaactgaat tatttgtaaa ctgtaaataa agaggaattg tgaataattg
    17401 aataattgat aaaattaaaa taagatttaa agtaagagag cctttcaact ttagcaactc
    17461 actttttaga attttgttca ttaattatcc tccacttcaa caaactaagg aaactcacaa
    17521 aaactaagat tgaaagagat actgatatta aaattgtcga tatttcaact ccacttaatg
    17581 ctgcctctaa atcacctgag ggttttaaat gtaaaagagc ataagcaatt ttatagtgat
    17641 aagtataagg aaatatgaac caaaccgatg tctgagctat tagaggagca actaataagc
    17701 aaataagaga atttgtagcc aacaacaagt agggatttat ccactttgct agaaaatata
    17761 atagtggtaa tacccaagca gaagaaacac caataagtaa taaacaaatc aaatctttac
    17821 caatgtctac tgatatcaca cctgaaaaaa gaaatgagat gccataaaat attatcgtaa
    17881 aaataaaggt tgaaatcaaa acatccttga acttcaacag tatcttcgct aaataaatag
    17941 taaacgtata tctacccaag ctaatatttt gaaacgcacc tgcattctcc tccgcgctat
    18001 aatcagctaa aaacaataac ccaaggagag tgaaaaggaa tcctccctcc caccaataaa
    18061 ttgaaaaact ttctaaattg agaggtcctg ctagtatgaa agctataaaa attgctagca
    18121 aaggaataag gattagtaat tttttatcag aactagattt ttgcttcagc cactcagatt
    18181 taaaaatatt agtcatttcc atcacctcca tggacaattc taaagaatag tttttctaaa
    18241 tcatttgaat tcttattaat atcatcgtaa aaaatcttgc cctgattcag tataacgatt
    18301 tgatccgcaa ttttgctgac ttcacttagt tgatggctgg acaagaggac tgtcattcca
    18361 gattttttta gatccctaat taaatttagc aattctttta tcccatctgg atctagacca
    18421 ttagttggct catctaaaat taataaatca ggattggtaa taattgccat tcctaaacca
    18481 agtcgttgct tcattcctaa tgaaaagtgc cctgccttct tttttccagt atcagataaa
    18541 ccaaccaact gaagtacctc acaaattctt tcatctggaa tatcatgtag caatgctcgt
    18601 gtttttaaat tgtcaaatgc agaaagattc aaatagatag caggagattc aatcaacgct
    18661 ccaatatcaa atctattttc ttctacaatg tccttatgct ttccattgaa aatgacttct
    18721 ccactatcag ctctttctaa cccaaaaaga attttcataa tggtggattt cccagcccca
    18781 tttactccca gaagaccaca aatagtacct tcttcaattt taaatgaaac gtcttttaaa
    18841 acctctttgt ctttatagct ttttcttaga ttttgaatga taacttccat tttttctgcc
    18901 tccatttctt ttattataat acaaaagaaa tttcagtatt tgttcagaaa aaaagattga
    18961 gcaaaaagtc gatatctcat tgattttttc aaattttcga aacaaaaaaa cgcataaaat
    19021 caacgtttgt aaatgaaaga tttcatgcgt ttttgtttat attaggcttt ttgaccagcc
    19081 cgtaaaattt ttttaattaa taaagtgacc tgtgcaccac cattttgtgg atttgagagt
    19141 attaattgac cttgatgtct catagctatc ttttgagcaa atgaaagtcc tattccgtaa
    19201 tgcttatcat ttcttccttt attatctgtg taaaaaagtt ttcctccatc tttaagagac
    19261 tcttctgtaa atggtaaacc attattccaa atctcaaaac tgataaagtt agaactttca
    19321 gatatagtca gtaccacctt gccctcttct gaacaaaatc tagtcgcatt agataagata
    19381 tttatcaaag ctcgatctaa gttgagacga tttcctttaa tcactctggt atgggattca
    19441 ttaactattt gaaaattaat tttttttgaa gacataatat ctcgacattc taatgataat
    19501 tcatcaagaa attttgctaa ttcaatatct tcctgataat tcttatcctc aattagcaac
    19561 cttgagtaat taaccattga attaaaatac ttttcaaata taccaacact atgatttatt
    19621 gaggacataa aatctaattg tttttcatct agattagtca tctcaagcaa ctcgatattc
    19681 ccctttaaaa cagttaatgg tgttttaata tcatgtgcta atgcagcaac ttgaaatgac
    19741 aaatcttctt tatctttttt ctccatttct aataactttg tcaactcttc gtctttttga
    19801 taaagcgtca ataaaatgtt attacattct aagatttcag tttctttacg tccaatatcc
    19861 attcctggta ttcccatatt cagagatatt ttttcaatta aacgaaaatt ttttgtaaat
    19921 tctcttaaga gcctgataac ggagatagag atgagtagta attctagcac tataaaaaac
    19981 aaataagaga ctaaattata ggaaatatgt cgaaagtttt gatttacaaa ttcgggcact
    20041 gttggtcttc taataaccaa aataaaatct gagttttcat attctgtaaa caatatagaa
    20101 ccctcgctaa ccgaacttcc agtatcaaaa acttctttat aatgttgtaa atcctgtttt
    20161 tgatattttc cagagaccaa ttcgccatta tcgctatcaa acaatacata atcaaagaca
    20221 gagtaatcca tttgattctt aataccgtta gcagatttac tatcactaat tgaaatatga
    20281 tagtctgttc catatgtatt caactgacct gtaaaaataa gaacgtagct caatacaagc
    20341 aacataataa catttgcaac tgtaccaatc actatttcaa gaactgtcct taaaatccgc
    20401 ttattaattg aatatctttt catcattcca cttatatccc atccccctta ttgttttaat
    20461 gggattaatt ccataggaac caaacttgac tctaatttga taaatgtatt ccgaaattga
    20521 acgaaataat gcatctgctt catcatcata gacacattca tagatttctt ctcttgtata
    20581 aaccttattt gtcttactag ataatagctc taaaatatca tattcccttt tagtaagaga
    20641 aatagcttca ccattaacac acacgagttt ttcttgaagg taaaatgtta gtggaagtaa
    20701 ttctcgaata acagattcat tagattcagc atttctataa cgttcttctc gttttaaatg
    20761 cgctgcaacc ttagcaacta gttgattaac actaaatggc tttgtgatat aatcgtcacc
    20821 accgagattt aagccagata caatatcatc ttcagaatct tttgcactga caaaaataat
    20881 cggagaggat actgatttac gaatctgttt acagatttgc agaccatcaa catttggcat
    20941 cataacatca agcaatatta aatcaaatcc atcaaaatca cttattttta taggaagcct
    21001 aacttcttga taagtcgtca cattatagtt tttcatttct aaaattgttc gcatcaattt
    21061 tacaatttca aaatcatcat caactaccaa aatcttatac atactaggta cctcttttat
    21121 ctcatactac tattttacac tattattgca caaaatttgt aatatttagt agcctaattt
    21181 gtccattgtt tccattatta ctaagaaaac aattatcata taaaattcga atagcttcat
    21241 ctggttggtc cttcaaatta tacttttcta taatcaatcc taaagctgca gagactttag
    21301 gagtcgaaat tgaagtccca tatgcatatg tatactttcc ttcaagcgtt ggaacaagaa
    21361 tccattcttt ttcatataat ttatcagcta cccatttatc atatcctact ttagaaagcg
    21421 cttgacttcc acctcctgtt gcatagatat caatgtcgcc attcccttga tttgagaaac
    21481 tagatacaag atcattatca tctactgaac caactgtaac aacattgtct aattcagccg
    21541 gaatatcttg tacagttcca tcaacttgac tataatcttt tcctcttaaa ctaccaagat
    21601 agttttttaa ttcatcttga ttctgtaaat ccatcccttc atcacctact gaagcaacga
    21661 caacggaacc ttgattatga gcataattaa ttgcccgttg atagatattg atcaaagctg
    21721 tatcatcatc ttcatcagtg gaatctctta acaaatattc tcctaaacta aggttaataa
    21781 catcaacatc atcttttgct gcttgaatga gcgctttgag aatccattgg tcttgagcat
    21841 tcccttcatc aaaaacacga tacattcgta ttttcatgtc aggtgctatc cctaaatatt
    21901 ctccacttga tgaaatttgt cccacaacag aggtcccatg gccaatttta tctacaacat
    21961 tttggttatc aactattcct gtttccaaat ctgatgtgaa attttgtact gaaataatgt
    22021 gtgaataaat atctggatta tcatatgtaa taccagaatc tattacacca attgttgctt
    22081 taccagaaga cttatgttga aatttacttc cagtactaat actcttttgc atatcccact
    22141 gatttcccca aaaatctaaa ttagtatttg tataaacctt gtccccatac aaataagtaa
    22201 tattaggctt tacagtcata gtattatcta taactatgtc atcaatataa ttagagtttt
    22261 ctttttttat tgtatcttca cttttttcgg tagaaatagt taaaaaattt atttcaggta
    22321 ttttatcagt aactttaatt ccttgacttt gtaaaacatc ttctacatcc tcaatagatt
    22381 tattttcact aactaaaaca ttataactaa tttccttatt ttcattagca cttactcctg
    22441 atgacacaga accgctagct aatataacaa taaacaatga tataaaaaca ttcgacaata
    22501 agcctatctt tttcataata tcatctcctt agttttttat tcctttttat caattttatt
    22561 tcagaatttc ttcagagtac tcaatatttg gtatcaataa atccgaaaaa tgctattctt
    22621 tcacattttt ttcactgtgt tcaaatttta gttcatcctt gcttgagtct atttcattta
    22681 aaattttgac aaacttttcc aacctcctta ttaaatactc ataatcatct attgacttat
    22741 ctaacttaat ttgatagatt tcgatttctt tctcaacttg ttccagtttt atagccgcag
    22801 ttagattcat cttggcatag tcatatttgg ccaagcggcg gttctctata tcgttattgt
    22861 ccaggttaag caagacttcc gcaaccttgt tgagatgatc tatgtgttcc tgaatctctg
    22921 taatggtcaa atctaattga gcaatatcct taataatctc gtctttaaaa tcttgataag
    22981 acttattctc cgtacccaac tcaataagaa gattaatctc ttcaatcttt ttcttaagtg
    23041 tgtcaatggt cggtcttttt cttttagaga tagtctggct atcattggtt aactgacgaa
    23101 tgagttcacg ccctcgcata tagcgattga gttcggacgc ctccttattg taaatgaaaa
    23161 attgtgcggt ctcacggata aaggcatggt agtgtttacc actctctgtc tctttaatat
    23221 ctaaatgacg gtttgggata aagaccaagc catctttttt aacgccgtag ttcattctga
    23281 taaagagacc atctttgact aacttatcaa tctgatggtc agctaagacg acatcaaact
    23341 cttgaacctg gtctcttttc tccttaaatg cctgataagc ctcttgcaag tcttcataag
    23401 ctagcttttc cttatcttgt tcctcacaat atccctcaaa gtcggaaata agttgcgact
    23461 ggtcaatatc aggaacttct ccacgtttct caaagtaagt ttcgaaaaat tgaacatcgt
    23521 agagattttt ggaactgact ttttgattat tgactgtaat gctctgacta ttttttgtta
    23581 gagtaaacgc cacattcttt tgttttagag acatagcaag gttgagttct cttgcaaact
    23641 ccaaaagttg tgaaaggtca cgaactctgg gtaagagaaa atctaaacat tgctcaatcg
    23701 ctcgcttggc aaagtgctct cgaaagtatt cctcggtata gggttgacgt ttatctagtt
    23761 gcttgcctcg aataactcgc ttcatgggca tatccgtcat caaaaaacga gcgtattttc
    23821 ttgaaaaatc aatctgaaca ttcaatgctt ctgccttgga taaaaagtcg tcaaaatcct
    23881 tactattctc catcagaaaa taaagacgtt gcttcaattc aaatttgtga ttacttttgc
    23941 gataggtcac aaacttctca tgagaataac ggttcggtgt gataattttg gcacctgctt
    24001 ctttggaaag acggtcagaa atcatccgta aatttctctc ctgagcataa tcccatttga
    24061 gtttcttatg agaattgagg tcaacagaat tgatgaggat atggttatga acatgcaacc
    24121 tatccgtatg ggttgtcaca ataaagcgaa agtttccgcc agtcaactcc tttatcgtct
    24181 cataaccaat acgattgatt tcttcaggtg taagattatc ctcaggtgag aatgactgga
    24241 taagatgatg agcatgaatt ttattttgct tgatttgttg ccggtcattt ctcgaatcat
    24301 aaagcctatc attattgaca aagtttgcct gatacatctc aactatttct tcataattag
    24361 ggaagtcgag gtaattgctc attccaaaat ctgaaaccaa tttgagttgg tcagtcttag
    24421 ctggatttag aatatacttg ataagacttt tacggtattt gttgccatga accgcaaaat
    24481 gtttagtgac taccataaaa ttccctcaac ttttgacact tgacatagaa gtccttatca
    24541 acttccgcaa tcagctgacc tatgcccgtt ttcaaattat ctcgctgctc tactgtcaga
    24601 agttttgtct gattgactgt tttagctatc tggttaatgt tattgccaat tcgacgtaat
    24661 tcaaaaacca agtcttggta gttactggta tcaattgtta aaaaggtcat atttggatta
    24721 agcaaaacct ttctggcata agcagaaaaa ttttgacaag aactttggct aatatgattg
    24781 ttcaggttcg caagttcctg gtctgttaaa aagacttttt tgagattggt tcgataacga
    24841 ttttccatat ctaacctccc atatacttat ctcgaaattc tgaactgagt ggtactgcct
    24901 tctctacttc tgtcatcagt tcttgaacac aagtcaatat aattcttaag tgttctgacg
    24961 tgacctgatg gcctcgttcc gctagagttg ctacctgtaa aatatctcta ctgatttgtt
    25021 ctattttttg agattgccac agaataaacc aatctctgat gtcatccttg ttattgacaa
    25081 tgtccaatag tttttgtcta acaaagggag aaaactgctc cgcattctcc tttctcatca
    25141 gtagttgaat ctgctcaaat tcctcaagcg tcaagttgat ttccttacga attgtccgat
    25201 aactttctgt catgatgata cactccttct cacatttccc tctagcgggt tagcaccgat
    25261 accatatctg atacgggggc tccctaaaag cctcaaatct tcccttttcg gcttttgcga
    25321 gctcagatat tgtgtccaca atatcccaaa aatcttatcg ccagccgacc aaaacctttg
    25381 agttttgata gccgatgata agataacttg gtggcttcgc ccccaaaccc ccagtgaaaa
    25441 atcatggatt gattttttta ggaatgatat taggataata gaggtgattt ggaaaaggta
    25501 tcacaaaaca aaaagtagga tatttctaac ctacttttca tttccttata ttattcagaa
    25561 agagctgtct catatatgga catcttatgt ttaaatgagt ctcttccacc ttccaattga
    25621 ttgataatat ggttttttat aaatttttca ctaacatatc cctgtgattc aatccaagca
    25681 tgagccccat ctgattccat aattaccact tgatcggtca tggaatttgt tacaattgtc
    25741 gcattatggg ttgctaaaat aatttgtcgt tgagctttca cgtctctaaa ctgttgaact
    25801 aaatgtctgt atatatagcg gttatccaaa ttatcttcag gttgatcaat aattaatggt
    25861 ctgaaatcct ttgaataatc actatatgct agtaaaaaat ctaacatcgc tacaactttt
    25921 tgacccaaac ttaatacact aacttcttta taaagaatgt caagatgttg tgatgtttct
    25981 tttgagttaa tgttaaactc caaaaaaagt ctttcattgg ctacgtgttc tttta
//
