Select genomic region:
Overview
29.1
30.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_JAMDIB010000003.1 (Streptococcus suis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 29.1 | T3PKS,terpene-precursor | 164,124 | 205,278 |

NZ_JAMDIB010000004.1 (Streptococcus suis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 30.1 | lanthipeptide-class-i | 47,067 | 73,101 | High | suicin 90-1330 | ribosomal:RiPP

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 29.1 | T3PKS,terpene-precursor | 164,124 | 205,278 |
Region 30.1 | lanthipeptide-class-i | 47,067 | 73,101 | High | suicin 90-1330 | ribosomal:RiPP

No secondary metabolite regions were found in these records:
  NZ_JAMDIB010000010.1 (Streptococcus suis)
  NZ_JAMDIB010000011.1 (Streptococcus suis)
  NZ_JAMDIB010000012.1 (Streptococcus suis)
  NZ_JAMDIB010000013.1 (Streptococcus suis)
  NZ_JAMDIB010000014.1 (Streptococcus suis)
  NZ_JAMDIB010000015.1 (Streptococcus suis)
  NZ_JAMDIB010000016.1 (Streptococcus suis)
  NZ_JAMDIB010000017.1 (Streptococcus suis)
  NZ_JAMDIB010000018.1 (Streptococcus suis)
  NZ_JAMDIB010000019.1 (Streptococcus suis)
  NZ_JAMDIB010000001.1 (Streptococcus suis)
  NZ_JAMDIB010000020.1 (Streptococcus suis)
  NZ_JAMDIB010000021.1 (Streptococcus suis)
  NZ_JAMDIB010000022.1 (Streptococcus suis)
  NZ_JAMDIB010000023.1 (Streptococcus suis)
  NZ_JAMDIB010000024.1 (Streptococcus suis)
  NZ_JAMDIB010000025.1 (Streptococcus suis)
  NZ_JAMDIB010000026.1 (Streptococcus suis)
  NZ_JAMDIB010000027.1 (Streptococcus suis)
  NZ_JAMDIB010000028.1 (Streptococcus suis)
  NZ_JAMDIB010000029.1 (Streptococcus suis)
  NZ_JAMDIB010000002.1 (Streptococcus suis)
  NZ_JAMDIB010000030.1 (Streptococcus suis)
  NZ_JAMDIB010000031.1 (Streptococcus suis)
  NZ_JAMDIB010000032.1 (Streptococcus suis)
  NZ_JAMDIB010000033.1 (Streptococcus suis)
  NZ_JAMDIB010000034.1 (Streptococcus suis)
  NZ_JAMDIB010000035.1 (Streptococcus suis)
  NZ_JAMDIB010000005.1 (Streptococcus suis)
  NZ_JAMDIB010000006.1 (Streptococcus suis)
  NZ_JAMDIB010000007.1 (Streptococcus suis)
  NZ_JAMDIB010000008.1 (Streptococcus suis)
  NZ_JAMDIB010000009.1 (Streptococcus suis)

Compact view
NZ_JAMDIB010000003.1 - Region 1 - T3PKS,terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 164,124 - 205,278 nt. (total: 41,155 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase reductase
M5P35_RS03515: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

M5P35_RS03550: hydroxymethylglutaryl-CoA reductase

smcogs
  SMCOG1187: hydroxymethylglutaryl-CoA reductase

Transferases: acetyltransferase methyltransferase
M5P35_RS03445: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

M5P35_RS03540: acetyl-CoA acetyltransferase

smcogs
  SMCOG1124: acetyl-CoA acetyltransferase

M5P35_RS03615: isoprenylcysteine carboxyl methyltransferase

smcogs
  SMCOG1150: isoprenylcysteine carboxyl methyltransferase

Hydrolases: deacetylase peptidase
M5P35_RS03440: methionine aminopeptidase

smcogs
  SMCOG1172: methionine aminopeptidase

M5P35_RS03525: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Isomerases: mutase
M5P35_RS03535: phosphoglycerate mutase

smcogs
  SMCOG1101: phosphoglycerate mutase

Ligases: synthase synthetase
M5P35_RS03545: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

M5P35_RS03595: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002397.2 |  |  | 0.43 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  |  | 0.37 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  |  | 0.29 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000205.3 |  |  | 0.29 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002561.3 |  |  | 0.27 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0001605.3 |  |  | 0.26 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000286.3 |  |  | 0.24 | PKS | viguiepinol | Streptomyces sp. KO-3988
BGC0001456.3 |  |  | 0.24 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000550.3 |  |  | 0.24 | ribosomal | salivaricin G32 | Streptococcus salivarius
BGC0000665.5 |  |  | 0.23 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.54 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.51 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000866.5 |  | 0.48 | other (other) | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0000867.3 |  | 0.46 | other (other) | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0002398.2 |  | 0.44 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000205.3 |  | 0.44 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0000278.3 |  | 0.42 | PKS | urdamycin | Streptomyces fradiae
BGC0001605.3 |  | 0.42 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0002561.3 |  | 0.42 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0001595.3 |  | 0.41 | other (other) | fischerindole | Fischerella sp. SAG 46.79

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
M5P35_RS03595: PT_FPPS_like
Domain 1 (25 - 281): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.45 out of 26.06
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.26 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.64 out of 26.06
Confidence: medium
Additional weak hits (3):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.22 out of 30.25
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.36 out of 36.54
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.42 out of 29.38
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes

NZ_JAMDIB010000004.1 - Region 1 - lanthipeptide-class-i
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 47,067 - 73,101 nt. (total: 26,035 nt) Show pHMM detection rules used
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: esterase protease
M5P35_RS03960: putative esterase

smcogs
  SMCOG1104: putative esterase

M5P35_RS04060: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase dehydratase
M5P35_RS04015: Lanthionine synthetase C family protein

smcogs
  SMCOG1140: Lanthionine synthetase C family protein

M5P35_RS04025: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-i | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001789.3 |  | 0.97 | ribosomal | suicin 90-1330 | Streptococcus suis
BGC0000537.3 |  | 0.85 | ribosomal | nisin U | Streptococcus uberis
BGC0000536.3 |  | 0.76 | ribosomal | nisin Q | Lactococcus lactis
BGC0000535.4 |  | 0.74 | ribosomal | nisin A | Lactococcus lactis subsp. lactis
BGC0000538.3 |  | 0.72 | ribosomal | nisin Z | Lactococcus lactis
BGC0000549.3 |  | 0.58 | ribosomal | salivaricin D | Streptococcus salivarius
BGC0000506.4 |  | 0.57 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0000559.4 |  | 0.55 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000556.5 |  | 0.55 | ribosomal | streptin | Streptococcus pyogenes
BGC0001618.3 |  | 0.54 | ribosomal | hyicin 3682 | Staphylococcus hyicus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001789.3 |  | 0.97 | ribosomal | suicin 90-1330 | Streptococcus suis
BGC0000537.3 |  | 0.85 | ribosomal | nisin U | Streptococcus uberis
BGC0000536.3 |  | 0.76 | ribosomal | nisin Q | Lactococcus lactis
BGC0000535.4 |  | 0.74 | ribosomal | nisin A | Lactococcus lactis subsp. lactis
BGC0000538.3 |  | 0.72 | ribosomal | nisin Z | Lactococcus lactis
BGC0000549.3 |  | 0.58 | ribosomal | salivaricin D | Streptococcus salivarius
BGC0000506.4 |  | 0.57 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0000559.4 |  | 0.55 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000556.5 |  | 0.55 | ribosomal | streptin | Streptococcus pyogenes
BGC0001618.3 |  | 0.54 | ribosomal | hyicin 3682 | Staphylococcus hyicus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for M5P35_RS04025

M5P35_RS04030
Leader:
MNNEDFNLDLVTISKENNSGASPR
Core:
V T S K S L C T P P G C K T G I L M T C A I K T A T C G C H F G
Core with dehydrations:
V Dhb Dha K Dha L Cys Dhb P P G Cys K Dhb G I L M Dhb Cys A I K Dhb A Dhb Cys G Cys H F G

#### antiSMASH-DB 4.0 matches for M5P35_RS04030

100.0%
NZ_JAMDIB010000004.1:
Lanthipeptides: M5P35_RS04030_lanthipeptide
1
V T S K S L C T P P G C K T G I L M T C A I K T A T C G C H F G
32
V T S K S L C T P P G C K T G I L M T C A I K T A T C G C H F G
1
V T S K S L C T P P G C K T G I L M T C A I K T A T C G C H F G
32
96.9%
NC_015600.1 and 14 others:
NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptide NZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptide NZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptide NZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptide NZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptide NZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptide NZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptide NZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide
Lanthipeptides: SGPB_RS10680_lanthipeptide
1
V T S K S L C T P P G C K T G I L M T C A I K T A T C G C H F G
32
V T S K S L C T P G C K T G I L M T C A I K T A T C G C H F G
1
V T S K S L C T P-G C K T G I L M T C A I K T A T C G C H F G
31
90.6%
NZ_CP024974.1 and 1 other:
NZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptide
Lanthipeptides: CVO91_RS06555_lanthipeptide
1
V T S K S L C T P P G C K T G I L M T C A I K T A T C G C H F
31
V T S S L C T P G C K T G I L M T C A I K T A T C G C H F
1
V T S I S L C T P-G C K T G I L M T C A I K T A T C G C H F
30
with 64 more sequence matches
Only the first 10 are displayed here.
87.5%
NZ_CP059471.1 and 3 others:
NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptide NZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptide NZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide
Lanthipeptides: H1R75_RS06635_lanthipeptide
1
V T S K S L C T P P G C K T G I L M T C A I K T A T C G C H F G
32
+T S K S L C T P G C K T G L M T C I K T A T C G C H F G
1
I T S K S L C T P-G C K T G A L M T C P I K T A T C G C H F G
31
77.8%
NZ_NHVL01000013.1 and 1 other:
NZ_NHVL01000013.1 Lanthipeptides: CEU70_RS16830_lanthipeptide
Lanthipeptides: CEU70_RS16825_lanthipeptide
1
V T S K S L C T P P G C K T G I L M T C A I K T A T C G C--H F G
32
V T S K S L C T P G C K T G I L T C A I K+A T C G C H G
3
V T S K S L C T P-G C K T G I L Q T C A I K S A T C G C S I H I G
35
69.7%
NZ_CP015405.2 and 7 others:
NZ_CP015405.2 Lanthipeptides: A4V09_RS08295_lanthipeptide NZ_CP015405.2 Lanthipeptides: A4V09_RS08290_lanthipeptide NZ_CP015405.2 Lanthipeptides: A4V09_RS08285_lanthipeptide NZ_CP053228.1 Lanthipeptides: HL650_RS06240_lanthipeptide NZ_CP053228.1 Lanthipeptides: HL650_RS06235_lanthipeptide NZ_CP053228.1 Lanthipeptides: HL650_RS06230_lanthipeptide NZ_CP053228.1 Lanthipeptides: HL650_RS06225_lanthipeptide
Lanthipeptides: A4V09_RS08300_lanthipeptide
1
V T S K S L C T P P G C K T G I L M T C A I K T A T C G C H F
31
+T S K S L C T P G C T G I L M T C ++T A T C G C
1
I T S K S L C T P-G C V T G I L M T C P V Q T A T C G C Q I
30
69.7%
NZ_JADNJR010000016.1 and 2 others:
NZ_JADNJR010000016.1 Lanthipeptides: I2E58_RS10875_lanthipeptide NZ_QSHK01000002.1 Lanthipeptides: DW860_RS04740_lanthipeptide
Lanthipeptides: I2E58_RS10880_lanthipeptide
3
S K S L C T P P G C K T G I L M T C A I K T A T C G C H F
31
S K S C T P G C T G I L M T C +K T A T C G C H
3
S K S A C T P-G C P T G I L M T C P L K T A T C G C H I
30
69.7%
NZ_QSHK01000002.1 and 1 other:
NZ_QSHK01000002.1 Lanthipeptides: DW860_RS04730_lanthipeptide
Lanthipeptides: DW860_RS04735_lanthipeptide
3
S K S L C T P P G C K T G I L M T C A I K T A T C G C H F
31
S K S+C T P G C T G I L M T C +K T A T C G C H
3
S K S V C T P-G C P T G I L M T C P L K T A T C G C H I
30
65.7%
NZ_FNDP01000013.1:
Lanthipeptides: BLP54_RS11230_lanthipeptide
1
V T S K S L C T P P G C K T G I L M T C A I K T A T C G C--H F G
32
+T S K S L C T P G C T G+L M C K T A T C C H G
3
I T S K S L C T P-G C V T G V L M G C N N K T A T C N C S V H V G
35
64.7%
NZ_CP090412.1 and 3 others:
NZ_QSTB01000004.1 Lanthipeptides: DXC22_RS03785_lanthipeptide NZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide NZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide
Lanthipeptides: LZF92_RS09890_lanthipeptide
1
V T S K S L C T P P G C K T G I L M T C A I K T A T C G C H F
31
+T S S L C T P G C K T G L M C +K T A+C G C H
1
I T S Y S L C T P-G C K T G A L M G C T M K T A S C G C H V
30
64.7%
NZ_FBTD01000003.1:
Lanthipeptides: PB1E_RS03075_lanthipeptide
1
V T S K S L C T P P G C K T G I L M T C A I K T A T C G C H F
31
+T S S L C T P G C K T G L M C +K T A+C G C H
1
I T S V S L C T P-G C K T G A L M G C N M K T A S C G C H V
30
62.9%
NZ_CP013655.1 and 2 others:
NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptide NZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide
Lanthipeptides: ATZ35_RS03640_lanthipeptide
1
V T S K S L C T P P G C K T G I L M T C A I K T A T C G C H F G
32
+T S K S L C T P G C T G+L M C A+K T T C C G
1
I T S K S L C T P-G C V T G V L M G C A L K T I T C N C S V G
31
62.9%
NZ_FNDP01000013.1 and 1 other:
NZ_FNDP01000013.1 Lanthipeptides: BLP54_RS11225_lanthipeptide
Lanthipeptides: BLP54_RS11220_lanthipeptide
1
V T S K S L C T P P G C K T G I L M T C A I K T A T C G C--H F G
32
+T S K S L C T P G C T G+L M C A +A T C C H G
3
I T S K S L C T P-G C V T G L L M G C A G S S A T C N C S V H V G
35

#### MIBiG 4.0 matches for M5P35_RS04030

61.8%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
1
V T S K S L C T P P G C K T G I L M T C A I K T A T C G C
29
+T S S L C T P G C K T G L M C +K T A T C C
1
I T S I S L C T P-G C K T G A L M G C N M K T A T C H C
28

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.38 out of 27.78
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.81 out of 20.97
Confidence: medium
Additional weak hits (1):
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 19.31 out of 27.18
Confidence: weak
Lanthipeptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

M5P35_RS04030 - Class I
  Cleavage pHMM score: 27.40
  RODEO score: 27
  Monoisotopic mass: 3084.5 Da
  Molecular weight: 3086.7 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3104.7 Da N = 1
    3122.8 Da N = 2
    3140.8 Da N = 3

RRE predictions
RREfinder results sidepanel.

lanthipeptide-class-i protocluster (47066...73101)
M5P35_RS04025
  RRE type: Lanthipeptide_LanB_RRE
  Location: 144 - 226
  Score: 25.6

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria