LOCUS       NZ_CP086373            27353 bp    DNA     circular CON 30-MAR-2024
DEFINITION  Paenibacillus polymyxa strain MEZ6 chromosome, complete genome.
ACCESSION   NZ_CP086373
VERSION     NZ_CP086373.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus polymyxa
  ORGANISM  Paenibacillus polymyxa
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 5769542)
  AUTHORS   Wang,L., Li,Z., Xiao,N., Tang,J., He,Y., Guo,J. and Zhao,X.
  TITLE     Genetic Characterization of blaNDM-1-Carrying Citrobacter
            portucalensis Sequence Type 328 and Citrobacter freundii Sequence
            Type 98
  JOURNAL   Infect Drug Resist 15, 2235-2242 (2022)
   PUBMED   35510156
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5769542)
  AUTHORS   Xie,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-NOV-2021) School of Life Sciences, Central China
            Normal University, NO.152 Luoyu Road, Wuhan, Hubei 430079, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 14-MAR-2019
            Assembly Method                   :: CANU v. 1.7.11
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 331.89x
            Sequencing Technology             :: Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023374295.1-RS_2024_03_30
            Annotation Date                   :: 03/30/2024 06:51:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,008
            CDSs (total)                      :: 4,851
            Genes (coding)                    :: 4,797
            CDSs (with protein)               :: 4,797
            Genes (RNA)                       :: 157
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 111
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 54
            CDSs (without protein)            :: 54
            Pseudo Genes (ambiguous residues) :: 0 of 54
            Pseudo Genes (frameshifted)       :: 24 of 54
            Pseudo Genes (incomplete)         :: 30 of 54
            Pseudo Genes (internal stop)      :: 14 of 54
            Pseudo Genes (multiple problems)  :: 13 of 54
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:46:42
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1058385
            Orig. end                         :: 1085738
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP086373.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..27353
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     cand_cluster    1..27353
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="neighbouring"
                     /product="lanthipeptide-class-i"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..24366
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24366
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14366](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14366
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(595..608)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: medium, score: 18.15"
                     /tool="antismash"
     gene            676..1440
                     /gene="aroD"
                     /locus_tag="LMH85_RS04760"
                     /old_locus_tag="LMH85_04760"
     CDS             676..1440
                     /EC_number="4.2.1.10"
                     /GO_function="GO:0003855 - 3-dehydroquinate dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="aroD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426256.1"
                     /locus_tag="LMH85_RS04760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04760"
                     /product="type I 3-dehydroquinate dehydratase"
                     /protein_id="WP_040102062.1"
                     /transl_table=11
                     /translation="MGKIVKINDVRIGEGAPKICVPMVGETLEQLKEEAAHLRTLDLDI
                     VEWRVDFFEHVEDLEKVKAALHEIRSILANIPLVFTFRSAREGGEKEISAASYVELNRT
                     VAETGQVDIIDVELFNEEADVKTLVEAAHKHNVYVIISNHDFQKTPPKEEIVSRLRKAQ
                     ELGGDLPKIAVMPTNTADVLTLLDATRTMAEEYADRPIITMSMAGKGVVSRLTGELFGS
                     ALTFGAAKKASAPGQIPVTELREILQVLHSHS"
     gene            complement(1541..2113)
                     /locus_tag="LMH85_RS04765"
                     /old_locus_tag="LMH85_04765"
     CDS             complement(1541..2113)
                     /EC_number="2.7.1.71"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0004765 - shikimate kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0008652 - amino acid biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819867.1"
                     /locus_tag="LMH85_RS04765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04765"
                     /product="shikimate kinase"
                     /protein_id="WP_016819867.1"
                     /transl_table=11
                     /translation="MQNNSEIPLKEQNIVLIGFMGVGKTTIGSHLARKLYRDFVDIDQE
                     IEQEYNMPTTEIFKTYGEKRFREIEKEHILKLCSNTRLKIISVGGGAFLQEEVKQACLA
                     SSIVFFLDLNWDSWKDRLKMLIDTRPNLQNKTLEEIEDLFRSRQDIYAVNHSKIDTDQL
                     DAEEVADYIIQTLNLGWELYEPTRGLN"
     misc_feature    2336..2356
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 24.85"
                     /tool="antismash"
     misc_feature    complement(2522..2537)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 22.59"
                     /tool="antismash"
     gene            2679..3371
                     /locus_tag="LMH85_RS04770"
                     /old_locus_tag="LMH85_04770"
     CDS             2679..3371
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819868.1"
                     /locus_tag="LMH85_RS04770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04770"
                     /product="pectate lyase"
                     /protein_id="WP_016819868.1"
                     /transl_table=11
                     /translation="MKTNTAKVLKKGMSIALSGMLIALFVGNYSAHAAPEVVHKTILVK
                     AGEVYDGKGKTVVADPDTLGDGSQKEAQKPIFKLENNATLKNVIIAAPAADGVHVYGNG
                     TISNVTWEDVGEDALTLKEPGTVNITGGGAFHAYDKVFQINAEGTINIKNFRADDIGKL
                     VRQLGGSTFRVNMTLDNSDISNVKDSILRSDGPNSKAKITNTRYHNVKQLFKGFKSGNT
                     SESGNTKY"
     gene            3509..4546
                     /locus_tag="LMH85_RS04775"
                     /old_locus_tag="LMH85_04775"
     CDS             3509..4546
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013308931.1"
                     /locus_tag="LMH85_RS04775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04775"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_017426257.1"
                     /sec_met_domain="APH (E-value: 6.2e-13, bitscore: 47.4,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVLLHFIQKSWVAMNLFHQYVSHDGTLNDTLVHSREILYTGTNG
                     RHVERFYVSSSESYIFKPLTNDDQKGRERWVYEHVLPALSPIYPQLLACSDTDADGGGE
                     WMVFEDLGPLHHLHADETLLQAVGFVARWHALPPGRFAGMPLRGPKPLIQEMVSELHIR
                     KPDILELCSSLGFSKQHMQRIYAQLEHLSFSHQLVLSHGDLHPGNYALSGEQLKVLDWE
                     HVHLNTPLWDVYHLIDMSHPLFPRHMTSKLRIRMLDTYLEQLELLGIQVDRTAFIQEYG
                     MFAVVFSLWMLLLITSDLQRIETELHRNSNKWSKEQLESQLDETLACLNQCTAMMDWGQ
                     VQPCK"
     misc_feature    3525..3538
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.72"
                     /tool="antismash"
     gene            4603..5601
                     /locus_tag="LMH85_RS04780"
                     /old_locus_tag="LMH85_04780"
     CDS             4603..5601
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014279969.1"
                     /locus_tag="LMH85_RS04780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04780"
                     /product="glycosyltransferase"
                     /protein_id="WP_017426258.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.6e-11,
                     bitscore: 41.6, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVGLVMRKIQFAEAQGPRIFAERLKQIGLELGVDIVFVSPERH
                     VSSHDWLPGYEHEKGDLVNYDIVLDQLHEQQIEHVIYTVSGFTYLNMFFKNSVLFPHSF
                     PDPALTGYEMMKPFYQIVDKAIVQTAFLKQEMASKFGVTDVTVIPIGFNERLVEKHFDP
                     SQVVENRVMWIGRDEENRRPDLVLEYARHNPDKDVYMVFGGERYKESMKKYDIPDNVKL
                     QFALTQDEVFALMNTAKVYWSCSKFDTFAMPLTEALAMGKIVVKPEHPCYGHISSTHSF
                     SGNEKNWFELVNMAAASPRRVSAENQTYAMEQFSSQVMKQGYRDFFDGWLS"
     gene            complement(5675..6883)
                     /locus_tag="LMH85_RS04785"
                     /old_locus_tag="LMH85_04785"
     CDS             complement(5675..6883)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369570.1"
                     /locus_tag="LMH85_RS04785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04785"
                     /product="MFS transporter"
                     /protein_id="WP_017426259.1"
                     /transl_table=11
                     /translation="MSTQENMTANRFPPSLLWLTLGAFAIGMTEFVIMGLLPNVAHDLH
                     VTIPQAGQLITSYALGVAIGAPVLTVLTHKVPQKKLLCLLMSIFILGNLFSVIAPNYEL
                     LIAARMATALSHGTFLGAGSLIAARLVRADKRAGAISMVLTGLTVANIIGVPFGTFIGQ
                     QLGWRASFGAIVVIGLISLFGIIRYIPVIQQDKPSSLKQEVKSLFNPKVLLMLLTGAVG
                     CGSLFTVFTYITPMLTDISGFAEHSITWILVLFGLGVTIGNIVGGKLADWKLLPSLVAN
                     YAVLAIILAILTFTLQNKVLAVITVFIWGIAAFGIMPGIQVRIMNLAYEAPLLASTSSH
                     SALNLGNAGGAFIGGVVINQMGLPAIPWVASLITVGGLLLMLVSYMMDRKTAHTEAIAE
                     IQS"
     cand_cluster    6757..27353
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    6757..27353
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[16756:17353](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      16757..17353
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="2"
     gene            7103..8026
                     /gene="cysK"
                     /locus_tag="LMH85_RS04790"
                     /old_locus_tag="LMH85_04790"
     CDS             7103..8026
                     /EC_number="2.5.1.47"
                     /GO_function="GO:0004124 - cysteine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006535 - cysteine biosynthetic process
                     from serine [Evidence IEA]"
                     /codon_start=1
                     /gene="cysK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819871.1"
                     /locus_tag="LMH85_RS04790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04790"
                     /product="cysteine synthase A"
                     /protein_id="WP_017426260.1"
                     /sec_met_domain="PALP (E-value: 2.2e-70, bitscore: 235.5,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLKVVHSITDLIGDTPCVRLQRLTGPQDAEVYVKLEYFNPSGSV
                     KDRAAGNLIAEAEKAGHLKPGGTIIEPTSGNTGIGLAMNAAARGYRAILVMPSNMTKER
                     INILKAYGAEVVLTPAEERMPGAIRKALELGAEIEGSFIPHQFENEANPDIHRTTTALE
                     ILEQTEGRLDVFVASSGTGGTITGTGEVLRQHLPDLRIVVVEPKGSPVLSGGKPGPHKL
                     VGTSPGFVPTVLNTEVYDEIIQVSDEDAIAMTRAIAAQEGILVGPSSGATIWTAIQEAR
                     RLGAGKRVLCIAPDTGERYLSMGIFG"
     gene            complement(8385..8510)
                     /locus_tag="LMH85_RS24995"
     CDS             complement(8385..8510)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LMH85_RS24995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_269203440.1"
                     /transl_table=11
                     /translation="MLSKKRSPYVYDMLDLVDELRFKQDMTVKELTDALRVHGIS"
     gene            8842..8988
                     /locus_tag="LMH85_RS04795"
                     /old_locus_tag="LMH85_04795"
     CDS             8842..8988
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038155.1"
                     /locus_tag="LMH85_RS04795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04795"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_226888859.1"
                     /transl_table=11
                     /translation="MFDLDLRKSYEASELSPQASIIKTTIKVSKAVCKTLTCICTGSCS
                     NCK"
     CDS_motif       8842..8895
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MFDLDLRKSYEASELSPQ"
                     /locus_tag="LMH85_RS04795_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       8896..8988
                     /prepeptide="core"
                     /locus_tag="LMH85_RS04795_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="14.70"
                     /molecular_weight="2943.6"
                     /monoisotopic_mass="2941.6"
                     /core_sequence="ASIIKTTIKVSKAVCKTLTCICTGSCSNCK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MFDLDLRKSYEASELSPQ"
                     /leader_location="[8841:8895](+)"
                     /alternative_weights="2961.6"
                     /alternative_weights="2979.6"
                     /alternative_weights="2997.7"
                     /alternative_weights="3015.7"
     gene            9055..9996
                     /locus_tag="LMH85_RS04800"
                     /old_locus_tag="LMH85_04800"
     CDS             9055..9996
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686236.1"
                     /locus_tag="LMH85_RS04800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04800"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_249507247.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 2.5e-21, bitscore:
                     74.4, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKPNIYNWHVARLTDHFSCGATVGQPLTILFIDTGVDKSHSEIQ
                     GNLVEAECKSFVPYEPCLSDYVGHGTKMVSSVTGKYILKGICPFAPVVVYKITDKKGIS
                     KLEWLYRALEEGIAKGYLIINISYRTEYEVDLFEFNRFQALVDCANAQGIWVVCSAGND
                     GRDITQEYRVPANLKGVYPIGSTNKNGDISGFSNTLSGQFFAPSGDEYEINYNNDWVMV
                     AKSSFDTEDYLYEVLGFDKAYTVGIGTSIASALFSGVVASLSGELIAQGMNAGRTEMEC
                     LLRQGARPIDVQRNYYEVSLAGSIRALRQMRG"
     gene            10001..13084
                     /locus_tag="LMH85_RS04805"
                     /old_locus_tag="LMH85_04805"
     CDS             10001..13084
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686237.1"
                     /locus_tag="LMH85_RS04805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04805"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_064962539.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 8e-114, bitscore:
                     379.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 7.9e-12,
                     bitscore: 43.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.4e-25, bitscore:
                     88.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLENFEISENYMYRKTLLGMEYYTRIFDHEQLDDDEYLDRLARFV
                     QKQGLMDSIYVSSPSTYAALQSLEQGRTLKSKKKRNLILSLSKFISRAICRPTPFGLFA
                     GVGISRFGNTGGAGEHVVWATPDYSLIYRLIGLFHGDADVRNELRLSVNNTSYIDHHRL
                     VISYQTLFAADQEERSTENISILKTPVIDFIMKILDKEQQTFLQLMQAIKDAFGVDDTI
                     STDFLQQLIEQGFLVSEMIPNPRDSAPLGHLIRTLKMLAAPKAAYYADILERVGHAIQD
                     ITVAAVKREGIEAVRKLVQLILPDYQGDLVKIDVRLNQANEIHLSDSDRQALAQVASIL
                     SMLSTYRKEDTLSDYRQQFTEKYGVYEEVPLLQLFSKTLGLGKPEEYKSHYQNGDKYRH
                     KDEGRFRQLKALIAEWQTEALANHSDIVLDEAKIQQLSELSLENVHVSFDLYYSCMENE
                     QGEVTFYLNNRAGSLEACQSFGRFAYMFDKDSRDEIFRFVRNPKDQKAGESAAEISFYP
                     FSPKITNIMTAGPTPDQSMDMATFPENRNLDISQLLVGVEDSGYFYLKHRETGELVFPK
                     LSSMYNTELAPYLIRFLNDINLQYQTGWSHLEEYLYDSSFTPRVTYKNIIICPKKWTLY
                     ADKRLQSEEQFLAFLEDWIIKYNIPRYVYLVELDNKLLLDLDRHHHRKLLHKEYTRNPE
                     GKAAVIMETEKELFASVNRYMEECVFFCKSPMFQYLPIDRLSAQATDKSLNKVLSSSVN
                     AVYYPGSDWISLQVYYNQELLTDLLGSAFKTFMDNSAEYFIDQVFFVQYADKEPHIRLR
                     CKMSGSVEHQRFTALNYVFDFLNTVTSSGLVSSYSVVPYRPEILRYGGAAFIEQAERLF
                     AIDSYLVSGYYAGKRSINATDQMLFCCTGLFEVVNCAYPLAEDQLKAMAAIIDPKKFRQ
                     EYREHKEALFERIQQTRSISLPASDKDDRLRQYAAYFTAIREADDRTNYYDDIMFSIMH
                     MFCNRVFGLDREKEELALHLCYYSLEDYLQVSKYHVAY"
     aSDomain        10448..10726
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_LMH85_RS04805_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="4.60E-14"
                     /identifier="RREFam001.1"
                     /label="LMH85_RS04805"
                     /locus_tag="LMH85_RS04805"
                     /protein_end="242"
                     /protein_start="149"
                     /score="43.9"
                     /tool="antismash"
                     /translation="LSVNNTSYIDHHRLVISYQTLFAADQEERSTENISILKTPVIDFI
                     MKILDKEQQTFLQLMQAIKDAFGVDDTISTDFLQQLIEQGFLVSEMIP"
     gene            13095..14366
                     /locus_tag="LMH85_RS04810"
                     /old_locus_tag="LMH85_04810"
     CDS             13095..14366
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426262.1"
                     /locus_tag="LMH85_RS04810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04810"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_017426262.1"
                     /sec_met_domain="LANC_like (E-value: 1.6e-48, bitscore:
                     163.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVKQVPGNLSEIVRQSAEIYKDIDTVTLLIKKHAMHDYPEMELI
                     SLASGYPGISLLLDKLDEVYPGEGWAALAFKYNQEIVRLIGNIPFHSLSLYTGLAGVIY
                     LFNECSRGSTRYTNVLSQTLDMFLSSYGEFYEETRGKLEDSLIEDSDLDLISGWTGIAA
                     TLMEVKERQDRYVGKLDAVLLKILQLITDAVGKLRHFEELPEQTIYYNLGMAHGITGAI
                     NLLAVAHLRRYPLTGLREVLEVAKTFLHGSIREWNGTLVIPNMFTPDESAETSRNPGYH
                     RDAWCYGTPGASVAMFRLGLALEDKALQQQALQLFNTVYSRPDSLRKVISPTICHGYAG
                     LVLIQHHFSRAAAMPFKDEFLHRLLSYRNTGEGVPFIDLEGSVDDPLSLDKVGLLDGCA
                     GVLLTLLTCDNENLSTWKQMLVFS"
     gene            14382..14939
                     /locus_tag="LMH85_RS04815"
                     /old_locus_tag="LMH85_04815"
     CDS             14382..14939
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819877.1"
                     /locus_tag="LMH85_RS04815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04815"
                     /product="DUF5823 family protein"
                     /protein_id="WP_017426263.1"
                     /transl_table=11
                     /translation="MFILLKEIITVMVGLITDFLSFQLDAYFYIWFLVLFISSLAATLV
                     QRSEGTITYSTAECVGINVLVVVLYLVIGTILARYFASFEDQQIVAEDKIMLYKISFML
                     TSAVIIVDIILDRLKRGRKFSYSLEFLAGSAVCFLLFQLSNQTDWIGTKLSLSYIVMVA
                     IAAGVYTMAMKFLLEYENHKEK"
     misc_feature    complement(14389..14402)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.81"
                     /tool="antismash"
     gene            14954..16747
                     /locus_tag="LMH85_RS04820"
                     /old_locus_tag="LMH85_04820"
     CDS             14954..16747
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426264.1"
                     /locus_tag="LMH85_RS04820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04820"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_249507248.1"
                     /transl_table=11
                     /translation="MELNMESTAYKKIGEEKQTAHSLLKLIKIARWPKLALAWSIVFTL
                     ISAAFSLVLPIITGKLVDKISAMELTIQTAAVLISLFLAGGILNAVSSLLLRYVGSKFF
                     QELRLKIWEKIIHLPVNYFDNNENGKIISRMTNDLAIVSNFLAITLPSILADVLMVTGC
                     IIMLFVLDWRLMSVLVALIPITALLIYPIGRRMNRVAVEAQDAAADFSGELSKILYNIR
                     FIKATTSEKLEMKYTREILGRIFRLNIKEGILSAVIEPIVTIIIMLALVGMFWYGSAGI
                     AAGHITTGTLVSMIFYLFTMVSPLTQLSSFFSQYQKAKGASKEIYTIYNQRDEKQEKLG
                     SVPDMKSHDQNSDILHFANVSFSYNQGQPVLSNVELTFRGCTTTAIVGPSGSGKTTIFS
                     LIEKFYSEYNGEIYYNNVYLDKIRTEEWRRKISYVMQDSDLLVGSVRDNLVYGLNRDAD
                     DHEIYAALDTVGLKEVIYQLPDGLDTFVGERGVKLSGGQKQRIQIARCLLSDHEILLFD
                     EATANLDSESEQLVHDVIKLLSKNKMTIVIAHRLSTIYKADQIIFLDKGEVTGVGTHHE
                     LMSWHDKYRDYVQFQLPAQLS"
     gene            16757..17353
                     /locus_tag="LMH85_RS04825"
                     /old_locus_tag="LMH85_04825"
     CDS             16757..17353
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686238.1"
                     /locus_tag="LMH85_RS04825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04825"
                     /product="accessory gene regulator AgrB"
                     /protein_id="WP_249507249.1"
                     /sec_met_domain="AgrB (E-value: 2.8e-32, bitscore: 109.7,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALYHQLSTWIVDKYFQDEELEAEKRAYVLYYLENILAGTEKILL
                     VLVSACLLGVLAETAAMLLSYTVVRRKSFGWHARKSHHCTWVSLLTFVFVPWLLKEVEW
                     NRFFLATLCLLSIILIVRYAPADTECNPLVDPKFRRACRLQAIFLSIVFVFVAIALDFY
                     PWLIFGLFLEAVVITPVFYSIMRRSYANYEQYQEY"
     gene            17582..18820
                     /locus_tag="LMH85_RS04830"
                     /old_locus_tag="LMH85_04830"
     CDS             17582..18820
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819882.1"
                     /locus_tag="LMH85_RS04830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04830"
                     /product="GHKL domain-containing protein"
                     /protein_id="WP_249507250.1"
                     /transl_table=11
                     /translation="MNYKLLLFLVMYYFIGITALNNFGLIVYLFLFVLLALYGWLTDKY
                     ESLWVIGFYAILTIFITTLLGYFITVISYAVPYEYKNKWTAPFLTACSPPLIYLALRKL
                     VSYLFPTPAIRLLKIYRIKLIVGASLILVLGIIGLGLIIYSECESNNPYPSRLKIVLML
                     IGLTSIFLMTINWLYRFLRERELEKNKTEQYLQLEAYIMEIEKMYEDIRGFRHDYTNIL
                     LMLDEGIRTGDLAMIKRIYESSIQPTASQLNGYSYSLDNLINLDVSELKSIITSKVLVA
                     KKRGVDVKLEIDSGISEMYMDIIDLCRVISCFLDNAIDAALETCNPSINIVLIHEDDIQ
                     TVTIRNSYNHSALDGIKVNDLYKRNFSTKADNRGLGLYNIAKVLRSNKYVTLDTKKEPD
                     FFTQTLIIKRATS"
     gene            18817..19596
                     /locus_tag="LMH85_RS04835"
                     /old_locus_tag="LMH85_04835"
     CDS             18817..19596
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819883.1"
                     /locus_tag="LMH85_RS04835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04835"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_017426267.1"
                     /transl_table=11
                     /translation="MNIFILEDQFIQQRIMEKMVRKSCEELGICCSNLIATSKPDLLLF
                     ESKACANNLYFLDIEISGCQMKGLEVAQEIRKYDMYGHIVFVTTHGHLSPLTFQYKVAA
                     LDFIIKDATQDEMEKKVREVLVVAHQRKPVLDVNDWFILDNKFTKFQISFSSIYYFETT
                     GVPHKIRLVSENRTLEFYGDLKDIEAKDPRLFRCHRAFIVNLMKVESIDKSKKEIIFQT
                     NQNSGEARRIIPVSRQLLKHLLDKMGDRSLLNRPVYE"
     gene            19643..20401
                     /locus_tag="LMH85_RS04840"
                     /old_locus_tag="LMH85_04840"
     CDS             19643..20401
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426268.1"
                     /locus_tag="LMH85_RS04840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04840"
                     /product="TraX family protein"
                     /protein_id="WP_017426268.1"
                     /transl_table=11
                     /translation="MEQRLSVQAEVKGIDATSLKLIAVLAMLIDHIGGLFFADFLGFQV
                     VGRITLPIMAFFVAEGYIHTRSFKKYTMRLALTGLASVVPYGLVFKDWYTSGNIMLTLL
                     MGLLAIWFYDNTTNPVLKYLAISALCVVSLLGDWSVIGVFLVLAFYVARKQQKIYNGWI
                     IAIIALMFIFGVIIIWAVPDSLSIMGINASTMNEYLYPFAIGGACIFALPLLSRYNGER
                     GKGPRTFFYLFYPLHLLALYLLKLAIDYYI"
     gene            20539..21516
                     /locus_tag="LMH85_RS04845"
                     /old_locus_tag="LMH85_04845"
     CDS             20539..21516
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426269.1"
                     /locus_tag="LMH85_RS04845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04845"
                     /product="aldo/keto reductase"
                     /protein_id="WP_249507251.1"
                     /transl_table=11
                     /translation="MKIMPLQKRGISDSRLVLGCMPFGGEWSHAPYTQEHVVEAERAVE
                     AAQSIGITMFDHADIYRMGKAEEIFGRILKGQPGLREQIVIQSKCGIFLPDGTLPGRFD
                     FSYDHIMESVDGILKRLGTEYLDILLLHRPDPLVEPEEVAKAFSELKTSGKVRHFGISN
                     MNVSQIRFLERSLTEPLIANQLEMSLAHLHFIDQTVHVNQQAGTNVHFGEGLLEYCQTE
                     DIQLQAWGPLAQGRFSGGSLEGKPEHIRKTAELVQKLASEKGTTREAIVLGWLMKHPAR
                     IQPVIGSANPERIQACQDAERQSELMTREEWYQLYVSARGQALP"
     gene            complement(21670..22470)
                     /locus_tag="LMH85_RS04850"
                     /old_locus_tag="LMH85_04850"
     CDS             complement(21670..22470)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819886.1"
                     /locus_tag="LMH85_RS04850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04850"
                     /product="WYL domain-containing protein"
                     /protein_id="WP_249507252.1"
                     /transl_table=11
                     /translation="MSLFEKIFNYQIVSRLDESGAFATTSQERVWLKSMLADSAATEAF
                     TPSTLDKLRQLLADDEPLEADGSLREKAGVPAASVYHPLLRELRSILRSRSGICMTYKL
                     RNGRLHERMSGFPYKLEFSMVKKEWSLLWYNRRHRAFMSTKLSNIVTVTEDEILPEEAE
                     KFTQRILGILESRKEQGIIEIIPVYNGEMSRILYAFSCFEKEVEYDQEADTYRITLTFQ
                     ADECEYVLSKIRFLGKRVKVVQGSRLISRMKETTAKALARYEEE"
     gene            complement(22445..23770)
                     /locus_tag="LMH85_RS04855"
                     /old_locus_tag="LMH85_04855"
     CDS             complement(22445..23770)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007428946.1"
                     /locus_tag="LMH85_RS04855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04855"
                     /product="WYL domain-containing protein"
                     /protein_id="WP_249507253.1"
                     /transl_table=11
                     /translation="MARESFDKEIQFLRMLTLTSGAYNRQQFADRLGISVHTFDKTIRR
                     LKEIVQSVQQQLPAEQGHDFNEMLRFNYYESADPLLLFLFRAKSLKESESVRLSLLLTA
                     LQSQSMTTMELLDACCNGLPSDSALPDEKTIRSDLKYLVEVGVVRKEPGGRPYRYAVRN
                     DLVTELTDEELLDLYDFVDVMANTQLPSVQGYLLRDHLKKAMRRQLGDREMAEPFLYKY
                     HYYSRILDEAHIHPLLHAIRQRRCVTFLYFSASKRSMYGSQNTNPRFEKETEGREHTIL
                     PLQVIYDHQYGRWYVLGHVGGKGIMKFRMEGMTQLVEGKPVPEQLYADLLAVLEEKMRY
                     SWLVDTGRPVKVRVRFFNPEGAKRNFIRERVLSQGQWGTITEEESESFIYEITVNGITE
                     IKPWIRSFGSSCEVLEPQRLRKEFRQEWKELQAYYEPVRENI"
     gene            23969..25537
                     /locus_tag="LMH85_RS04860"
                     /old_locus_tag="LMH85_04860"
     CDS             23969..25537
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369575.1"
                     /locus_tag="LMH85_RS04860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04860"
                     /product="limonene hydroxylase"
                     /protein_id="WP_102998721.1"
                     /transl_table=11
                     /translation="MFGRFKNEVLYPWVGKLSIYETIKQGLDPQGRLTDDHLPDDEEYW
                     AGHTMRWVAGGLDGAFGHHGAGGDGETEKIKELAHLLSRQCRKPGMKTRRETYVRLMEE
                     NALSLIDPLLDAVREHPAIQPDRLYEEARWLAEHGAHRNVVKVGIALLGLLETEQHHEL
                     ILTLAKHDEFTLYAAVAIRNISDQANEQLYNLALQVHGWGRIHVVERLEPARQEIRDWL
                     LREGFRNNVMYEYLAYECAHKGELHTAMAVPHIDRELFDGAGDILSALLAAGGPAESID
                     DYEHAAMVIGNYLRHAKTMCTTVKHLTIIMDIADFLDEEDDSWEARYEHEWTPELRKRY
                     ASVCQQMMDDPQWVKLVEQELHHADSPHLHCAIRAARMLVLDVWPVLFDQLSKHPVKPN
                     LYFELSKTEDEQRACKLVAFAEKHLPLGEIASGPADVPGFGPEYEAHQCLGMLLQLLSS
                     YEGMGQELVATGLWSPVTSNRRAALHVLKEWPSEMWGEATIERLRCLSEAETEESIREQ
                     IREIL"
     gene            25557..26375
                     /locus_tag="LMH85_RS04865"
                     /old_locus_tag="LMH85_04865"
     CDS             25557..26375
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369576.1"
                     /locus_tag="LMH85_RS04865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LMH85_04865"
                     /product="nucleotidyltransferase domain-containing protein"
                     /protein_id="WP_249507254.1"
                     /transl_table=11
                     /translation="MTDMKHGQGFIQPEMRETILRELRALEQEEQVRIVYACESGSRAW
                     GFPSQDSDYDVRFIYVRPIEWYLSIFDKRDVIERPISNMLDINGWDLKKALHLFRKSNP
                     PLLEWLQSPIPYLEQYSVADQIRAISPLTFSPKSCMYHYLNMARGNYRDYLQGEQVKIK
                     KYFYVLRPLLACGWIERYNSMPPMEFVDLLEEFIPADTELYQVIELLLERKKAGEELDM
                     EPQLSVVNDFIEQQIAYFEQKAPLLQHMEGGRDQQLDEMFRAAVNEVWKT"
     misc_feature    26507..26522
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.26"
                     /tool="antismash"
     misc_feature    26889..26902
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
     misc_feature    complement(27028..27041)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.33"
                     /tool="antismash"
ORIGIN
        1 gatttacagg acctaccttg ctgtatattg tgcagttatg gctgcctact tttgggcaac
       61 agtttatcgg catgacggaa tcagagtctc tgaggctatt agtttattac aatatgggtt
      121 cgctggtttc cgtgtttgta ttggtcattg tattgagaaa atgggttaaa cctgttcata
      181 tcatccttat ttatccttgc atttccttgt tggcttttgg agcgcttctt cttttcaaat
      241 ctggggctgc cgccattatc tgtgcgagtg tcatcgggtt ttcaatatcg ggtgtacttc
      301 agctgacgtt aaccgtaatg agtgaatttt ttagtcaacg aaaaggacag attaccgggt
      361 ttatttatac cgcaacttcg ctgtcctata cgctcattcc cgtgtttaca ggctttcttt
      421 tgaagcattc tcagatttcc agtgtgttta tgctggctat tatcgtgaat gtacttggaa
      481 tcgcactggc ggtatttgtt aactttcgtt acagtgccgt ttttcctgca aaacgagaat
      541 tgtctcctca aattgtactg gatacgaaat aactagcgac tgaacctaat catctgcatg
      601 cttattcaga atgcgttata ctatgaatta ttgtgaatgt tcgacttgaa actgtaattg
      661 gggagtgaga tagatatggg aaaaatcgta aagataaatg atgtacggat cggtgaagga
      721 gcgcctaaaa tatgtgttcc catggtggga gaaacgttgg agcagttgaa ggaagaggct
      781 gcccatttac gaacactcga cctggatatc gtagagtgga gagtcgattt tttcgagcat
      841 gtggaagatc tggaaaaggt aaaggctgcc ttacatgaaa ttcggtctat tttagccaat
      901 attccactcg tatttacgtt ccgtagcgcc cgagaaggtg gagaaaagga aatcagtgct
      961 gcaagttatg tggaattgaa tcgcactgtg gccgagacgg gacaagtaga tatcattgat
     1021 gtagagcttt ttaatgagga agctgatgtg aagacactgg tagaagcagc acacaagcat
     1081 aacgtatatg tgatcatttc taaccacgat ttccaaaaga cgccgccgaa ggaggaaatt
     1141 gtgtcccggt tgcgtaaggc acaggaattg ggcggcgatc tgcctaaaat agcggtgatg
     1201 ccaaccaata cagccgatgt actgacctta ctggacgcca cacgcactat ggcagaagag
     1261 tatgcggatc ggccgattat cacaatgtcg atggcgggaa aaggtgtcgt gagccgtctg
     1321 accggagagc tatttggttc agcgttgact tttggtgctg ccaagaaggc ttctgcaccg
     1381 ggacagattc ctgtcactga actgagagaa atattgcagg tgctgcatag ccactcttaa
     1441 gagatgcaat tactacccac tagcgagcaa ggaattcata gtgaacacaa aaggaggacc
     1501 ccatgcgata agcatgctgg ggtcctcctt tttgtaatgc ttaattcaat ccccgagtag
     1561 gttcatacaa ttcccaaccc agattcagtg tttgaataat atagtctgcg acttcttccg
     1621 catccaactg atcggtatcg atcttggagt gattcaccgc gtaaatgtcc tgtctggaac
     1681 ggaaaagatc ttcaatttcc tctaacgtct tgttttgcag attagggcgg gtgtcaatca
     1741 gcatcttgag ccgatctttc caggaatccc aatttaaatc caagaagaac acaatggagg
     1801 aagccaaaca agcctgcttc acctcttcct gtagaaacgc gccaccgcca acagaaatga
     1861 ttttaagacg cgtattgctg cacaacttca aaatatgctc tttttcaatc tcacggaaac
     1921 gcttctctcc gtaagttttg aaaatttctg ttgtaggcat gttgtactct tgttcaatct
     1981 cctgatcaat atccacgaaa tcgcgataca gcttgcgcgc tagatgggaa ccgatcgttg
     2041 ttttgcccac gcccataaag ccgatgagca caatattttg ttcttttaat ggaatctcac
     2101 tattgttttg cacataacca ctcttttctc accagtaatg ttgagatgta acgcttcaaa
     2161 gcactaaata cattatacgt tcatcaaccg tgtcattcaa tagtatagag cacatcagca
     2221 atgaggtata cgataaaaga gactctgatt accaatggag tgatagaaca gcaggtaaaa
     2281 aactaggtat tcaagtgtta tgtaatgcgt aaatggaaga aaaacaaact tgtacaagta
     2341 taaaagaggc aatattgtgt acttaattga aaaaaaggac atattttgcc gaaaaacgta
     2401 ttgaaattat tggaagtagg aatataatag agttatgcaa attgtaaatg taatcgctct
     2461 atttacaatt tgtgattgat ttaatttata aaaaagaaag ctactttgaa ccaaaaacca
     2521 agtatacata tgcaaataat taaatatcac tttacggaca tgtatcggtc aatgggttca
     2581 ttgtacgaag gtggtgatac ggtctacgcg cttacgctct agtcaacgaa gaattggaga
     2641 taagaataaa aaacgatcta ggagagggat gaattgaaat gaaaacaaac acagctaaag
     2701 tattgaaaaa gggcatgagt atcgctttat ccggtatgtt aatcgcgtta tttgtcggca
     2761 attactctgc ccatgcagct ccagaggtcg ttcacaagac catacttgtt aaagctggag
     2821 aagtatacga tggtaaaggc aagaccgtag tggctgaccc cgacaccttg ggagatggaa
     2881 gccagaaaga ggctcaaaag cctatcttta agctagaaaa taatgcaacg ctgaaaaatg
     2941 tgatcatcgc tgcacctgct gcggatggtg tgcatgtata tggcaatggc accatttcca
     3001 acgtaacgtg ggaggatgtc ggtgaagatg cattgacgct taaagaacca ggcacggtga
     3061 acattacagg tggtggagcg tttcatgcat atgataaagt attccaaatc aatgccgaag
     3121 gcacgattaa cattaaaaac tttagagccg atgatatcgg taagctggtt cgccaacttg
     3181 ggggctctac gtttagggtg aatatgactt tggataactc ggatatttcc aacgtcaagg
     3241 attcgatcct cagatcggac ggtcctaaca gcaaagctaa aattacgaat actcgttatc
     3301 ataatgtaaa acaattgttc aaaggtttta aatctggcaa tacgagcgag tccggcaata
     3361 ctaaatacta atcgttagcg taggatagga gtacgatagg aaaggggctg tccaacaggt
     3421 cgtatgatct gataggacat gccccttttt tggtatgtta agttaaccct aagatgatct
     3481 gggcttcgtt cagaacgagg actatgttat gatcgtgcta ttacatttta tacaaaaaag
     3541 ttgggtggct atgaatctat ttcatcaata tgtgagtcat gacggtactt taaatgatac
     3601 gctggtgcac agtcgtgaaa ttttatatac aggtacgaat ggccgacatg tggaacgttt
     3661 ttacgtgtcc tcctctgaaa gttatatatt taaacccctg accaatgatg atcagaaggg
     3721 acgggagaga tgggtgtatg agcatgtgct tccagcatta tcacccatct atccccaatt
     3781 gctagcttgt tccgatacag acgcagatgg cggaggagaa tggatggtgt ttgaggatct
     3841 tggtccgtta catcatctac atgcagatga aaccctattg caagctgttg gatttgtcgc
     3901 aaggtggcat gctttgccgc cgggtcgttt tgccgggatg ccattgcgtg gaccgaagcc
     3961 gctcatccag gagatggttt ccgagctgca catacgcaag ccagatatat tagagctttg
     4021 cagctcactc ggtttttcca agcaacacat gcagcgtatt tatgcacaac tggagcatct
     4081 atctttttca caccagcttg tactgtctca tggtgatctt catccgggga actatgcgct
     4141 gagtggggag cagttaaagg tattggattg ggagcatgtt catctaaaca caccgctgtg
     4201 ggatgtatat cacctgatcg acatgtccca tccgttattc ccccgacaca tgacgtctaa
     4261 attgcgtatt cgtatgttgg acacctatct ggaacagctg gagctgttgg ggatacaggt
     4321 agatcgaacg gcatttatac aggaatatgg tatgtttgct gtggtatttt cgctttggat
     4381 gctattacta atcacaagtg atttgcaaag gattgaaacg gagctgcata gaaatagcaa
     4441 caaatggtca aaagaacaat tagagtccca gttggatgaa acgttagctt gtttaaacca
     4501 atgtacagcg atgatggatt ggggacaagt ccaaccatgt aagtagtcgg tttaaggcct
     4561 agattctata tagttagcca aagaaggtag ggaaataaat ccatgaaaaa agtcggtttg
     4621 gtcatgagaa aaatacaatt tgctgaagcg cagggtcctc gtatttttgc agaacgtctg
     4681 aagcagatcg gattggaact gggagtggat atcgtatttg tatcaccgga gcgccatgta
     4741 agcagccatg actggcttcc gggctatgag cacgaaaagg gtgacctagt caattatgac
     4801 atcgtactgg accaactcca tgagcagcag attgagcacg ttatttatac ggtatctggt
     4861 tttacctatt tgaacatgtt tttcaaaaac agtgtactct ttccacatag ttttccagac
     4921 ccggcactga caggctatga gatgatgaag cctttttatc agatcgtgga caaggctatc
     4981 gtacagactg cctttctcaa gcaggagatg gcctcgaagt ttggcgtaac cgatgtgaca
     5041 gtcatcccga tcggatttaa tgagcggttg gtggaaaagc attttgatcc ctcacaagtg
     5101 gtggagaacc gggtgatgtg gattggtaga gatgaagaga atcggcgtcc ggatctggta
     5161 ctggagtatg cgcggcataa tcctgataag gatgtctata tggtatttgg cggtgaacgc
     5221 tacaaggaaa gcatgaagaa gtacgacatc ccggacaatg taaaacttca atttgcatta
     5281 acgcaagacg aggtgtttgc actgatgaat acggcgaagg tgtattggag ctgctctaaa
     5341 ttcgacacgt tcgcgatgcc gctgaccgaa gcgctagcca tggggaaaat cgtcgtcaag
     5401 ccggagcatc cttgctatgg gcacatcagc tctacgcatt ctttttcagg aaatgagaaa
     5461 aactggttcg agctggtcaa tatggctgcg gcttcacctc gccgggtttc tgcggagaat
     5521 cagacatacg ccatggaaca gttttcgagt caggtgatga agcagggata ccgagacttt
     5581 tttgatggtt ggttaagctg aacgacgagg caggatgcgt ggatttagac cataaaaaaa
     5641 ggactttcgc tctaatgaac gaaagtcctt tttcttatga ctgtatctct gctatcgctt
     5701 cagtatgagc cgtcttgcga tccatcatgt agctgaccag catcagcagc agaccgccga
     5761 cagtaatgag tgatgcaacc catggaatgg cgggtagccc catttggtta ataacgactc
     5821 ctccgataaa agcaccgcct gcgttgccta gattcaatgc ggaatggctg gaggtagagg
     5881 ctagcaaagg agcctcatag gccagattca tgatacgaac ctgaatcccc ggcatgatgc
     5941 cgaatgcggc aatcccccag ataaagacag tgatcacggc cagtaccttg ttttgaagcg
     6001 taaacgtcag aatggccaga ataatggcca gtacagcata gtttgcaacc aaggacggaa
     6061 gcagcttcca atctgcgagc ttgccgccaa cgatgttgcc aatcgtgaca cctaggccga
     6121 acaggacgag aatccaggta atgctgtgtt cggcaaagcc actaatatcc gtaagcatgg
     6181 gcgtaatgta cgtaaagaca gtgaacaagc taccacagcc aactgcacct gtgagcagca
     6241 tcagcagcac ttttggatta aacaggcttt tgacttcttg cttgagactg gaaggtttgt
     6301 cctgctgaat caccggaatg taacgaataa taccgaagag agaaatcaag ccgatcacaa
     6361 caatggctcc aaaggaagcg cgccagccga gctgctgccc gataaaggtg ccaaagggca
     6421 cgccaataat attcgccacg gtcaatccgg tcagcaccat agagatggct cctgcccgct
     6481 tatcagcacg aaccagccgg gcagcgatca aggaacctgc tcccaagaag gttccgtgcg
     6541 ataacgcagt agccatacgg gccgcaatca gcagttcgta gttaggagca atgacggaaa
     6601 aaagattgcc taaaatgaat atggacatca gcagacacaa cagctttttt tgcggaacct
     6661 tatgggttaa tacagtaagc acaggtgcgc caatggccac accaagcgcg taactggtga
     6721 ttaattgccc ggcttgcgga atcgtaacat gaagatcatg ggctacattg ggcagaagtc
     6781 ccataatgac gaattcggtc atgccgatgg cgaaggcacc aagggttaac catagcaagg
     6841 agggggggaa gcgattagct gtcatatttt cttgagtact cataagtttc ttgtatcctc
     6901 ctgaaaaaat agtaatgcga gtatatcatt ccaggcaaca tctggcgacc cattttgcaa
     6961 gaattttaca tactaagttg ataaggtttg tgtaatttac aaaagcgaca ggttggaagg
     7021 agccaattat gttattttgg tggtagtatg atatgaagat aggaaatgac gttgtaagga
     7081 atgatccggg gaggatataa caatgacact taaagtggta catagtatta cggacttaat
     7141 cggagatacg ccttgtgtgc ggctgcaacg gctcacagga ccgcaggatg cggaagtgta
     7201 tgtgaagctg gagtatttta atccaagcgg cagtgttaaa gatcgggcgg cgggcaatct
     7261 gattgccgag gcggaaaagg cgggacatct caagccggga ggcacgatta ttgagccaac
     7321 cagtggcaac acggggattg gtcttgcgat gaatgcggca gctcgaggtt accgtgcgat
     7381 tttggtaatg ccttcgaata tgacgaagga acggatcaat attttaaaag cctatggggc
     7441 tgaggtcgta ctgacaccag cggaagaacg gatgccagga gcgattcgta aagctctcga
     7501 actgggggca gaaattgaag ggagttttat cccgcatcag tttgaaaatg aagcaaatcc
     7561 tgatatccat cgtacaacca cggcacttga aattttggag cagacggagg ggcggttgga
     7621 tgtgttcgtc gcttcttcgg gaacgggtgg taccattacg ggtacaggtg aagtgctgcg
     7681 ccagcatttg ccggatctgc ggattgttgt ggtcgagccc aagggttcgc ccgtcctatc
     7741 tgggggaaaa cccggtccgc ataagctggt gggaacgagt ccgggctttg ttcccaccgt
     7801 gctgaatacg gaagtgtatg acgaaatcat acaggtttcc gatgaggatg cgattgcgat
     7861 gacacgggcg attgctgctc aggaagggat tctcgtcggg ccctccagtg gggctacaat
     7921 atggacggcc attcaggaag cccggcgttt gggagcaggc aaacgggtac tctgcattgc
     7981 cccggatacc ggagagcgtt atctgagcat ggggatattc ggataaaaag atggggatcg
     8041 ggtcaaagag attcgactca tttatatgta agatccagcc tcattaatcg aagttacaga
     8101 agtgaattgg cgatatggta gacataaaca ttgaatacat ctttgccata ttcataggtt
     8161 aatttcactc ctgacaaatc aataagccac aattcataag gttatggcta attaattgtc
     8221 gattatagct tatattcgtg agaattttaa aagtctcacg attcatgttc cgttcttcga
     8281 ccttatttgt ttcttcagga tcctcttgaa aaacccaagt aatcagagaa ggaaacacca
     8341 agcctattct ccatttcagc aagagctgcc tcaaacgggt caacttatga gatgccgtgt
     8401 acacgtagtg cgtcggtcaa ttcctttaca gtcatgtcct gtttgaatcg cagttcgtcc
     8461 acaagatcca gcatatcgta aacatagggc gagcgctttt tgctaagcat ctcttcttca
     8521 gccgacttat atgagacacc tgtataggaa cataccggat tcttgcaagc atacgtcatg
     8581 ctctaagcgt caatcgttcc gctctgtgtc ggtatttttt ttgtcatgct gcatgggaag
     8641 caaattgact gcaatttagg aggtttggaa taccttttag gaataaagta taaaaaacgg
     8701 gagaattaga tatattcttt attcatcgac agcaagatat gacatacagt cactcacaat
     8761 aaacgtgatt taggggtacc actgaaatca tgtttattag aattaaattc agagaggaag
     8821 aggaaaatga aagtagatca aatgtttgac cttgatttaa gaaagagcta tgaggccagt
     8881 gagcttagcc cacaagcttc aatcatcaag acaaccatta aggtatccaa agcagtatgt
     8941 aaaactctta cctgtatctg taccggttct tgttccaatt gtaaataatt cataagcgat
     9001 tcgtaagtca ggggtagtga aatgggctac ccctacttac attatggaga ttgtatgata
     9061 aaacctaata tatacaattg gcatgtagcc cggctgaccg atcattttag ttgtggtgca
     9121 actgttggtc agccgcttac tatcctgttt attgatacag gcgtcgataa atcccactca
     9181 gagatccaag gtaatctagt tgaggcagaa tgcaagtcat ttgtacctta tgagccttgt
     9241 ctaagcgatt acgtcgggca tggtacaaaa atggttagct ctgttactgg caaatatata
     9301 ttgaagggga tatgcccttt cgctccggtt gttgtctaca aaattacgga caaaaaagga
     9361 ataagcaagc ttgaatggtt gtatagagcg ctggaagaag gtattgctaa aggatatcta
     9421 attatcaaca tcagctatcg tacagaatat gaggtcgact tattcgagtt caatcggttt
     9481 caggctttgg ttgactgcgc taatgcgcaa ggcatctggg tagtctgttc cgcaggaaac
     9541 gatggacgcg atattacgca ggagtacaga gtgcctgcga atttaaaggg agtataccca
     9601 attggatcaa ctaataagaa cggggatatc tccgggttca gtaatacgct cagcggccaa
     9661 ttttttgcgc cgagtggtga tgagtatgaa atcaattaca acaatgattg ggtaatggtt
     9721 gccaaatcaa gcttcgacac agaggattat ttatacgaag tgctgggatt tgacaaagca
     9781 tacacagtag gtatcggtac gagtattgcc agcgccttat tcagcggagt tgttgcctct
     9841 cttagcggag agcttatcgc gcaggggatg aatgccgggc gcacagaaat ggagtgtctg
     9901 ctccgtcaag gcgcgagacc gattgatgtt cagcggaatt attatgaagt aagccttgcc
     9961 ggttcaattc gtgctttaag acagatgaga ggttgattgc atgttggaaa actttgaaat
    10021 ctcggaaaat tacatgtacc ggaagacgtt gcttggcatg gagtattata cgcggatatt
    10081 tgatcatgaa caactagacg atgatgaata tcttgacaga cttgcacggt tcgttcagaa
    10141 gcaggggttg atggattcca tttatgtctc cagcccctcg acctacgctg cgctgcaaag
    10201 cctggaacaa ggcagaacat tgaagtccaa aaaaaagcgg aatcttatcc ttagtctaag
    10261 caagttcatt tcgcgggcaa tttgtagacc aacaccgttt ggactgttcg cgggggtagg
    10321 catttcccga ttcggaaaca cgggaggcgc cggagaacat gtcgtctggg caactccgga
    10381 ttatagccta atttaccgct taatagggct tttccatggg gatgcggatg tccgcaatga
    10441 attgagactg agtgtaaata acacctctta cattgaccat cacaggctcg tcatctctta
    10501 tcagactctg tttgcagcag atcaggagga acgaagcact gaaaatatat ctattctcaa
    10561 aaccccggtc atagatttca tcatgaagat ccttgataaa gagcagcaga cttttctgca
    10621 gcttatgcaa gctataaaag atgccttcgg cgtggatgac acgatcagca cagatttttt
    10681 gcagcaattg atagaacaag gctttttggt aagtgagatg attcccaatc ctcgggatag
    10741 cgctcctttg gggcatctga tccgtacact aaagatgctc gctgctccca aggcagcata
    10801 ttacgcagat attttggaga gagttggaca tgccattcag gacatcacag ttgctgcggt
    10861 caaacgcgaa ggcattgagg ctgttcgaaa actagtccag cttatccttc ccgattatca
    10921 gggcgacttg gtcaaaatag acgtaaggct gaatcaagca aatgaaattc acttatcgga
    10981 cagcgatagg caagcgttgg cccaagtagc ttcaatattg agcatgcttt ctacgtacag
    11041 gaaagaggat acactttccg actatcgtca gcaatttact gagaagtacg gagtatatga
    11101 agaagtgccc ttattgcagt tgttcagtaa gacgttgggg ctcggcaaac ctgaagagta
    11161 caagagccac taccagaacg gagataagta caggcataag gatgaaggca ggttccgaca
    11221 gctcaaggcg ctaattgcgg agtggcagac tgaagcgctt gccaatcatt cggatatcgt
    11281 gcttgacgag gccaaaatcc aacagctgtc tgaattgagt ctggagaatg tccatgtctc
    11341 gttcgatttg tattattcct gcatggagaa tgaacaaggt gaagttacgt tttatttaaa
    11401 caacagagcc ggatcattgg aagcgtgtca aagcttcgga agatttgcct acatgtttga
    11461 caaagatagc cgtgatgaaa tcttccgttt tgtcaggaac ccgaaggatc agaaagcagg
    11521 ggagagcgcc gctgaaatct cattttaccc attcagcccc aaaataacta atattatgac
    11581 ggcaggccca acaccggatc aatccatgga tatggccacg ttccccgaga atcggaattt
    11641 ggatatttcc caactactgg taggggtgga ggattcggga tacttttatc taaagcacag
    11701 ggaaacaggc gaactggtat ttcccaaact cagcagtatg tacaatacag agctggcgcc
    11761 ttatctgatc cggtttctga atgatattaa tctgcagtat cagaccggat ggtcccatct
    11821 ggaggagtat ctctatgatt cttcttttac accgagagta acctataaaa atatcatcat
    11881 ctgccctaaa aaatggacat tatatgcgga taaacggctc cagagcgaag aacagttttt
    11941 ggcctttttg gaggattgga tcataaagta taacattccg cgatatgtat atttggtgga
    12001 gctggacaat aagctattgc tggatttgga tcgccatcat catcgaaagc ttttgcacaa
    12061 agaatatacg cggaatccgg aaggcaaggc ggctgttatt atggagacgg agaaagaatt
    12121 gttcgcttcc gttaaccggt atatggagga gtgcgtattt ttttgcaaaa gcccgatgtt
    12181 tcagtacttg ccgatagaca gattgtctgc acaggctacc gataaaagct taaataaagt
    12241 gctgagttct tcggtgaatg ccgtttatta tccaggttcg gattggatat ccctgcaggt
    12301 atattacaat caggaactgc taaccgattt gctgggcagt gcatttaaga cattcatgga
    12361 caatagcgcc gagtacttca ttgaccaggt tttttttgtc cagtatgcag ataaggagcc
    12421 gcatatcagg ctaaggtgca aaatgtcggg aagcgtagag catcagcgtt tcacggcctt
    12481 gaactatgtt tttgattttc tgaatactgt aacctcgtcc ggattggtta gttcctattc
    12541 ggttgttcct taccggcctg aaattttgcg gtatggcggc gcagccttca ttgaacaagc
    12601 ggagaggtta tttgctatcg attcttatct agtttcaggc tattatgcag gcaagaggtc
    12661 aattaatgca accgatcaga tgttattttg ctgcaccgga ctttttgagg ttgtgaactg
    12721 cgcgtatccg ctggcagaag atcaattgaa ggctatggct gcgattattg atccgaagaa
    12781 attcagacag gagtaccggg aacacaaaga agcgctattc gaaaggattc aacagacccg
    12841 ttccatatcc ttgccagcaa gcgataaaga cgacaggttg cggcaatacg ctgcatattt
    12901 cacggctatc cgggaagctg acgacagaac caattactac gatgatatta tgttcagcat
    12961 catgcacatg ttctgcaaca gagtgttcgg cctggaccgg gaaaaagaag agcttgccct
    13021 acacctatgc tactacagtt tggaagatta tctacaggta agcaaatatc atgttgccta
    13081 ttgaggagga gcttatggcg gtcaaacaag tcccgggaaa tttatctgaa atagtcaggc
    13141 aaagcgcaga aatttacaaa gatatagata ctgtaaccct gctaatcaag aagcacgcca
    13201 tgcatgatta ccctgaaatg gagctgatat cgctggcttc aggatacccc gggatcagcc
    13261 ttcttctgga taagctagat gaagtttacc cgggggaagg gtgggctgcg cttgctttca
    13321 agtacaatca ggagattgtg cgtttaatcg gtaatatacc gttccattca ttgtcactgt
    13381 ataccggatt agcaggcgtt atttatctgt tcaacgagtg ttcaagaggt tcaacaagat
    13441 atacgaatgt gctctcgcag acgctggata tgtttcttag cagctacggg gagttctatg
    13501 aggagacaag agggaaattg gaagactctt tgattgagga tagcgacttg gatttgattt
    13561 caggctggac ggggattgca gctacattaa tggaggttaa ggaacgccag gacagatacg
    13621 ttgggaagct ggatgcagtg ctccttaaga tacttcaact gattacggat gctgtaggca
    13681 agctgagaca tttcgaggaa cttcccgaac agaccattta ttataatctt ggcatggcgc
    13741 acggaattac aggagccatt aatctgctgg ccgttgcaca tctccgccgc tacccgttaa
    13801 ctggattgag agaagtactg gaagttgcca agacttttct acacggaagt atcagggagt
    13861 ggaacggcac ccttgtcata cctaatatgt tcacaccgga tgaatccgca gagactagtc
    13921 ggaatccagg ttatcacaga gatgcatggt gttacggcac accgggagct tctgtggcta
    13981 tgttccggct gggattggcc ctggaggaca aagcactgca gcagcaggct ctgcaattgt
    14041 tcaataccgt ctactccaga ccagattcgc taagaaaggt aatttcaccg acgatctgtc
    14101 acggctatgc aggcttggtc ctgattcagc accatttcag ccgtgcggca gccatgccgt
    14161 ttaaggatga atttttgcat cgtttgttat catatcgaaa tactggtgag ggagtacctt
    14221 ttatagacct tgagggaagc gtcgatgatc cgttatctct cgataaagtt gggctgctcg
    14281 atggatgtgc aggtgtattg ctgacactgc tgacctgtga taatgagaac ttgagtacat
    14341 ggaagcagat gctggtattt agctaacagg aggagacggt aatgttcatt ttattaaaag
    14401 aaattattac agtcatggtg ggactgatta ccgattttct ctcttttcaa ctggatgcat
    14461 atttttatat ttggtttctg gtcctgttta tttcaagctt ggcagcgacc ctggttcaac
    14521 gaagcgaagg gactattacc tacagcacag ccgaatgtgt cggaataaat gtgctagttg
    14581 tcgtattata cctagtaatc ggtacaattt tggccagata ctttgcaagt tttgaggatc
    14641 agcagattgt tgctgaagat aagattatgc tgtataaaat ttcttttatg cttacatccg
    14701 ctgtaattat agtggatatt attctagata ggttgaagag agggcggaaa ttctcctact
    14761 ctttggagtt tcttgccgga agcgccgtgt gcttcttact gttccagtta agcaaccaaa
    14821 cggactggat aggaaccaag ctgtcgctct cctatattgt catggtagcg atagccgcag
    14881 gtgtctatac aatggcaatg aagtttttgc tagaatacga aaatcacaaa gagaaatagg
    14941 tgattaagcc ataatggaat tgaatatgga gagcacggca tataaaaaga tcggagaaga
    15001 aaaacaaacg gcccattcct tgctgaagtt aatcaaaatt gcgagatggc ccaagcttgc
    15061 gcttgcttgg agcatagtat ttacactgat ttccgccgct ttttcattag tattgccgat
    15121 cattacaggc aagcttgtcg ataagatctc agctatggag ctgacgatcc agaccgcagc
    15181 tgtgcttatt tcgctgtttc tggccggagg gattttaaac gccgtgtctt ctctgctcct
    15241 cagatatgtg gggagcaagt tttttcagga actgcgactg aaaatttggg aaaaaattat
    15301 ccatttgccg gttaattatt ttgataacaa cgagaacggc aaaatcatca gcagaatgac
    15361 gaacgacctt gctattgtaa gtaattttct agctatcact ctgccttcta ttctggctga
    15421 tgtcctgatg gtcactggtt gcatcatcat gttatttgtg ttggattgga gattaatgag
    15481 tgtactcgtt gctctgattc ctataacggc gctactaatc tatcccattg gaagaaggat
    15541 gaatagggta gcggttgagg cacaggatgc agccgcagac ttttccggtg agttatccaa
    15601 aattctctat aacatcagat tcattaaagc gacgacgtcg gaaaagcttg aaatgaaata
    15661 tactcgggag atacttggac gtatctttcg cttgaacatc aaagagggaa tattgtcagc
    15721 tgtcattgag ccgattgtca caattatcat catgctagct ttggtaggaa tgttttggta
    15781 tggaagcgcc ggcattgccg ctggacatat cactacaggt actctggtat ccatgatctt
    15841 ttatttgttt acaatggttt cgcctctgac ccagcttagc agttttttct cgcagtatca
    15901 aaaggctaag ggagcaagta aggaaattta taccatatat aaccagcgag atgagaagca
    15961 agaaaagtta ggcagtgtgc cggacatgaa aagtcatgat cagaattcgg atatcctgca
    16021 ttttgccaat gtttctttct cgtacaacca gggccaaccg gtattatcca acgtggagtt
    16081 aaccttcaga ggctgtacca ctacagcgat cgtagggcct tccggctcgg gaaaaacaac
    16141 aatattttct ttaatagaga aattttactc agaatataat ggagaaatct attacaataa
    16201 tgtatatttg gataagatta ggacggaaga atggcgtcgc aaaatatcct atgttatgca
    16261 ggatagtgac ttactggtag gatcagtgag agacaatctg gtatatggcc taaacagaga
    16321 cgcggatgac catgagattt atgcggctct tgatacagta ggcttgaagg aggtaattta
    16381 tcaattaccg gatggtttgg atacctttgt tggagaaagg ggagtcaaat tatcgggggg
    16441 acagaagcag cgaatccaga ttgccagatg cttgctttca gaccatgaga tcctgctgtt
    16501 tgatgaagct accgccaacc tggatagcga gtcagagcag ctcgtccatg atgtaatcaa
    16561 gcttctctcc aagaataaaa tgaccattgt tatcgctcat cgtttgtcaa ccatctacaa
    16621 agcggaccag ataatctttt tggataaagg agaagtaacg ggggtaggca cgcatcacga
    16681 attaatgagt tggcatgata aatatcgtga ttatgttcaa ttccagcttc ccgcacaatt
    16741 aagttaggga ggggcggtgg cgttgtatca tcaattgtca acgtggatcg ttgataaata
    16801 ctttcaagac gaagaattgg aagcggagaa gcgtgcttat gtgctttatt atctggagaa
    16861 catactggct ggcacagaaa aaatacttct tgtattggtc agtgcctgtt tgctcggtgt
    16921 attagccgaa acggctgcga tgctgctttc ctatacagtg gtccggcgaa agtcctttgg
    16981 ctggcatgct cgcaagtcgc atcattgcac ctgggtcagt ctactgacct ttgtgtttgt
    17041 tccctggctc ttaaaggaag tagaatggaa ccgctttttt ttggcgacgc tctgtctgct
    17101 ttctatcatt ctgattgtca gatacgctcc ggccgatacg gagtgcaatc cattggtaga
    17161 tccgaagttc agaagagcat gcagattaca agctatcttt ttaagtatag tgtttgtttt
    17221 cgtggccatc gcactagatt tttatccttg gttaatattt gggctgtttc ttgaagcagt
    17281 tgtcatcaca ccagtattct attccataat gagaaggagt tatgccaatt atgaacaata
    17341 tcaagaatat taaagaatac agaaacaacc atacccagag actcaaggct aagctactgg
    17401 agcatatgag taaaagaggt gaaggaggag gaatttgttt cgggttgttc tatgaaccag
    17461 tcaacccaaa agtttggaaa ttgaacaaaa aatgattaca tccggcattt attttttgca
    17521 atacaccagc tatcttgtaa tatatcatat ggtcagcggc aatggtctaa gcgttttccg
    17581 tatgaattat aagctactgc tgtttttagt catgtattat tttatcggaa taacagctct
    17641 gaataacttc ggactgattg tttacctatt tctatttgtg ctactggcat tatacgggtg
    17701 gttgaccgac aaatatgaat ctttgtgggt cataggcttc tacgctatcc ttaccatctt
    17761 cattacgaca ctgctgggtt atttcataac ggtaatcagc tatgcggttc cttatgaata
    17821 taaaaacaaa tggacggcgc ccttcctaac cgcttgttca cctccgctga tctacttggc
    17881 gctccgaaag cttgtgtctt atttgtttcc tactccggcg atcaggcttt tgaagatata
    17941 tcggattaag cttatcgtcg gagcttcttt aatcttagtc ttggggatca tcggactagg
    18001 actcattatc tattcggagt gtgaaagcaa caatccgtat ccaagcagat taaagattgt
    18061 gttgatgctg atcggcttga cctccatctt cctgatgacg atcaattggc tgtatcgctt
    18121 cctgcgtgaa cgtgagctag agaagaacaa gacggaacaa tacctgcagc tggaggctta
    18181 tattatggag attgaaaaaa tgtacgaaga catccgcggc ttcagacatg actataccaa
    18241 tatcctgtta atgctggacg aggggatcag aactggggat ttggcgatga tcaagcggat
    18301 atatgagagt tctatccaac ctactgcttc acagttgaac ggatattcct atagtctgga
    18361 taacctgatt aatctggacg taagtgagct caagagtatt attacatcca aggtgctggt
    18421 ggcaaagaag cgtggagttg acgtaaaact ggaaattgat agcggtatca gtgaaatgta
    18481 tatggatatt atagaccttt gcagagtaat ctcttgtttc ctggacaatg caatcgatgc
    18541 ggcactagag acctgcaatc cgtccataaa tattgtgctg atccatgaag acgatattca
    18601 gacggtgacg atacgaaact cttataatca ttctgcactt gacgggatta aggtgaatga
    18661 tctctacaaa cggaactttt caacgaaagc ggacaatcga ggtcttggct tgtacaatat
    18721 agcaaaggtg ctgcgcagca acaagtatgt aactttggat accaaaaagg aaccggattt
    18781 tttcacgcaa acattaatta taaagagagc gacatcatga atatttttat tctggaagat
    18841 cagtttatcc agcagcgcat aatggaaaag atggtccgta aaagctgcga ggaacttggc
    18901 atctgctgca gcaatctcat tgccaccagt aagccggatc tcctgctttt tgaatctaaa
    18961 gcttgtgcga ataacttgta tttccttgat attgaaatct ctggttgtca gatgaaggga
    19021 ctggaagttg cccaggaaat cagaaaatat gatatgtatg ggcatattgt ctttgtaact
    19081 acccacggtc atctgtctcc gcttaccttc caatataagg tagcagctct tgatttcatt
    19141 atcaaggatg ctactcagga tgaaatggaa aaaaaggtca gagaagttct tgttgttgcc
    19201 catcaaagaa agcctgtgtt ggatgtcaat gattggttta tactcgacaa taaatttacg
    19261 aaatttcaaa tttccttctc cagcatttat tactttgaaa caaccggtgt tccccacaaa
    19321 atccgtctgg tttccgaaaa cagaactctt gagttttacg gcgatctgaa agatattgag
    19381 gctaaggacc caaggttgtt ccggtgtcat cgggcattta tcgtaaacct gatgaaggtg
    19441 gaatctatag ataagagcaa gaaggagatc atttttcaaa ccaatcagaa ttccggagaa
    19501 gcaaggcgca ttattcccgt ttcccgccaa ttgttgaagc acctcttaga taagatggga
    19561 gaccgtagcc tcctgaacag acctgtttac gaatagaata gatacggagg gcatagtcct
    19621 tcgggaagaa aaggggagga atatggaaca aagattatcc gttcaagcag aggtgaaagg
    19681 cattgatgcc accagtttaa aattaattgc agtattggca atgctaattg atcatattgg
    19741 agggctattt tttgccgatt ttttgggctt tcaggtggta ggcagaatta cattgcctat
    19801 catggctttt tttgtagccg aaggatatat ccataccaga agcttcaaaa aatatacaat
    19861 gcgccttgct ctaaccgggc tagccagtgt ggtgccttac ggattggtat ttaaagattg
    19921 gtatacttcg ggaaacatca tgctaacgtt gttgatgggc ctactggcaa tatggttcta
    19981 tgacaacacg accaatcctg tgcttaaata cttggcgatt tcggctcttt gcgtagtctc
    20041 tcttttggga gactggagtg tgattggagt gttcctggtt ctggctttct atgtggctcg
    20101 caaacaacag aagatttaca acggatggat tattgcaata attgcgctta tgttcatttt
    20161 cggagtcatc attatatggg ctgttcccga ttcgctcagc atcatgggca tcaacgccag
    20221 cacaatgaac gaatatcttt atccgtttgc gatcggcggg gcctgtattt ttgcactccc
    20281 tttgctatcc cgatataacg gagagagggg aaaaggccca cgaaccttct tctatttgtt
    20341 ttatccgctg catttgctcg cgctttatct gctgaagttg gctattgatt attacatata
    20401 agaagggctg tctaataagt aactaaaata aaaaatcaga cgggaaacga catgttttcc
    20461 gtctgatttt tgcggtttga cgaactattc gaatgttgat gaagcaagga atactttgag
    20521 ggttcaagga ggagcagcat gaaaattatg cctttacaga aacgtggaat ctccgatagt
    20581 cggctggtgc ttggctgcat gccttttggt ggagaatgga gccatgcacc gtatacacag
    20641 gagcatgtcg ttgaagcaga gagagctgta gaagctgcac aatccatcgg gattacgatg
    20701 tttgatcatg cggatatcta tcgtatggga aaagcggaag aaattttcgg tcggatttta
    20761 aagggacagc ccggattgcg tgaacaaatc gtaattcagt ccaaatgcgg catttttttg
    20821 ccggatggca cgctcccagg ccgttttgat ttctcatatg atcatattat ggagtccgta
    20881 gatggtatct tgaagcgtct gggtactgag tatttggaca tcctgctgct gcaccgcccc
    20941 gatccgctgg tagagccgga agaagtagca aaggcgttca gcgagcttaa gacatccggc
    21001 aaagtacggc attttggaat ttccaatatg aatgtaagcc aaattcgttt tctggagcgc
    21061 agcctaacgg agccgctgat tgctaatcag ctggagatga gcctggcaca tctgcatttt
    21121 atagatcaga ccgtacacgt gaaccagcag gcagggacga atgtacattt tggcgaaggt
    21181 ttgctggaat attgccaaac cgaggatatt cagctccagg cttggggacc gctggcgcag
    21241 gggcgtttta gcggaggttc tctggaagga aaacctgagc atatccgtaa gacggcagag
    21301 ctggtacaaa aactggcctc tgaaaagggg acgacacgcg aagcgatcgt cctgggctgg
    21361 cttatgaagc atccggcacg gattcagcct gtcattggca gcgccaatcc tgaacgaatc
    21421 caagcatgtc aggatgccga acgccagagc gaactgatga cccgtgagga atggtatcaa
    21481 ttgtatgtaa gtgcgcgcgg tcaagccttg ccgtaactgg tactgcggac tagcttgtta
    21541 cagcagacgt gtgcggatgt aagtgtatga cctcgtttat atgaattgta gtttaatagg
    21601 ccctcctttc gtctcattaa cagacagagg gagggccttt acatggatag atcctaattt
    21661 ctgcagcagc tattcctctt cgtaccgtgc gagggctttg gctgttgttt ctttcattcg
    21721 cgaaattaag cgagagcctt gaacgacctt gacacgtttg ccgaggaagc ggattttgga
    21781 tagcacatat tcacactcgt ctgcctggaa agtgagtgta atacgatagg tatctgcttc
    21841 ctgatcatat tcgacctcct tttcaaaaca ggaaaaagca tataaaatac gagacatttc
    21901 accgttgtat acaggaataa tttcaatgat gccctgttct ttgcgcgact ccagtatacc
    21961 gagtattcgt tgggtaaact tctcggcttc ttcaggaaga atctcatcct ccgtaacggt
    22021 tacgatgttg gatagtttag tagacataaa tgcgcggtgt cgtcgattat accacagcag
    22081 actccattct tttttgacca tggaaaactc cagcttatag gggaatccgg acattcgctc
    22141 atgcaggcga ccgttgcgca gtttgtaagt catacagatg ccggagcggg atcgcagaat
    22201 ggaacgcaat tcacgcagga gcggatgata aaccgaagca gcaggaactc ctgccttttc
    22261 gcgtaggctg ccatcggcct ccaaaggctc gtcgtctgca agtaattgcc gaagcttatc
    22321 aagtgtagac ggggtaaaag cctctgtcgc tgccgagtct gcaagcatgg acttaagcca
    22381 gactctttcc tgcgaggtgg tagcaaaagc gcccgattca tccaaccgtg agacaatctg
    22441 atagttaaat attttctcga acaggctcat aataggcttg cagctccttc cattcctgtc
    22501 tgaattcctt acgcagccgc tggggctcca atacctcaca gcttgatccg aagctgcgaa
    22561 tccacggttt aatctcagtg attccattca ctgtgatttc gtagataaag gattcacttt
    22621 cttcctccgt aatcgtaccc cattgtcctt gtgacagcac acgttcccga ataaagttgc
    22681 gttttgcccc ttcgggatta aaaaaacgta cccttacctt cacgggacga cccgtatcaa
    22741 caagccagct gtaccgcatt ttttcctcca acacggctaa caggtcggca taaagctgtt
    22801 ctgggacagg cttgccctcc accaattggg tcatgccctc catacgaaac ttcatgattc
    22861 ctttgccgcc cacatgacca agcacgtacc aacgtccata ttgatgatca tagatgactt
    22921 gcaagggcag aatggtatgt tcacggcctt cagtctcttt ttcaaatcgt gggttggtgt
    22981 tctgtgaccc gtacatgctt cgtttggatg ccgaaaaata taaaaaggtt acgcagcggc
    23041 gttgccgaat ggcatgcaga agcggatgaa tatgggcttc gtccagaatg cgtgaataat
    23101 aatggtattt atataaaaaa ggctctgcca tctcccgatc tccgagctgg cggcgcatgg
    23161 cctttttaag atgatctcgc aacagatatc cctgcacaga ggggagctga gtgttggcca
    23221 taacgtccac aaaatcatat aagtccagta attcctcgtc cgtcagttct gtcaccagat
    23281 cgttacggac agcatagcga tagggtctgc cgccaggctc cttacgaact acgccgactt
    23341 cgaccagata tttcagatca gaacggattg ttttttcatc tggcagtgca ctgtcggaag
    23401 gcagcccatt gcagcaagcg tccaacagtt ccatggtggt catagactgt gattgtagcg
    23461 ctgtcagcag aagggataag cggacgcttt ccgattcctt gagcgatttg gcccgaaaca
    23521 ggaataacaa taatgggtca gcggattcgt aataattaaa gcgcagcatc tcattaaaat
    23581 catgtccctg ttccgcaggc agctgctgtt gtacggattg gacgatttcc ttgaggcgcc
    23641 ggatcgtctt atcaaaggta tgtaccgaaa tgccaagtct gtctgcaaat tgctgccgat
    23701 tataagcgcc gctggttagt gtgagcatac gcaggaactg aatttcttta tcaaaactct
    23761 ctctcgccat gatgcattcc ccgtttctgt agccgttctc cgaaaataag tatcccttta
    23821 ttctaacagg gaagggatgc aggaaaaagg taatttattc atctttgtaa tactttcacc
    23881 atgttcatga cttccaaaat aaaggattat agggatataa ggtagcacga taagtaaaaa
    23941 gtcatacata acagaagggt gaggcaacat gtttggacga ttcaaaaatg aagtgttata
    24001 tccatgggta ggtaagcttt cgatttatga aacgattaag cagggactgg accctcaggg
    24061 aaggcttacg gatgatcatt tgccggatga tgaagaatac tgggcaggtc acacgatgcg
    24121 ttgggtggca ggggggctgg atggagcgtt tgggcatcac ggcgctggcg gagatggaga
    24181 gactgagaaa attaaggagc tagcacactt gttgtccaga caatgccgca agccagggat
    24241 gaaaacaaga cgtgagacat atgtacgctt gatggaggaa aatgcgctca gcctgattga
    24301 tccgctgcta gatgcggtgc gcgaacatcc agcaattcag ccggatcgat tgtatgagga
    24361 agcgcgttgg ctggccgaac acggagcaca tcgcaatgtg gtgaaggtcg gtattgcgct
    24421 gctcggattg ctggagacag agcagcacca cgagcttatt ttaacgctag ccaagcatga
    24481 tgaattcacg ctatatgcgg ctgtagctat ccgtaatatt tcggatcagg ccaatgagca
    24541 gttgtataat ttagccttac aggtacatgg ttggggacgt attcacgtcg tggaacgact
    24601 ggagccggcg cggcaggaaa tacgtgattg gttattacgg gaaggattcc gcaataatgt
    24661 catgtatgag tatcttgctt atgagtgcgc tcataaaggc gagctgcata cagccatggc
    24721 tgtaccgcac attgatcggg agttgtttga cggagcaggc gatatactgt cggctttgct
    24781 ggcggcaggc ggacctgcgg aaagtataga cgattatgag catgccgcta tggtcatagg
    24841 caactacctt cgtcatgcta agactatgtg tacgactgtg aagcatctta cgatcatcat
    24901 ggatattgcg gacttcctcg atgaagaaga cgattcatgg gaggcacgtt atgagcatga
    24961 atggacgccg gaattacgta aacgttacgc gtcggtatgc cagcagatga tggacgatcc
    25021 gcagtgggtg aagctggtag agcaggaact acatcatgca gattcaccgc atcttcactg
    25081 tgccattcgc gcagctcgaa tgctagtact agatgtatgg cccgtgctat ttgatcaatt
    25141 aagcaaacac ccagtcaagc ctaatctgta ctttgaactt agcaagacag aggatgaaca
    25201 gcgggcatgt aagctggtgg cttttgcaga aaagcacttg cctctgggag agatagcttc
    25261 cggtcctgct gatgtgccgg gctttggacc agagtatgaa gcgcatcaat gtctggggat
    25321 gctgctgcaa ctattgtctt cttacgaagg aatgggacaa gagctagttg ctaccggact
    25381 ttggagcccg gtgacctcca atcgccgtgc agcgcttcat gtactcaagg aatggccttc
    25441 tgagatgtgg ggagaggcaa cgatagagcg ccttcgttgc ttatcggaag ctgaaacgga
    25501 ggagtcgatc agagaacaga ttcgggaaat actttaagga taagggaggg aacaacatga
    25561 cagatatgaa gcatgggcag ggtttcattc aaccggaaat gcgcgaaacg attttgcgtg
    25621 agctgcgcgc gctggagcag gaagagcagg tgcgcattgt atacgcctgt gaatcaggca
    25681 gtcgggcatg ggggtttcct tcacaggaca gtgactatga tgttcgattt atttatgtaa
    25741 gacccataga atggtattta tctatttttg ataagcggga tgtgattgag cggccaatca
    25801 gcaatatgct ggatataaac ggctgggatt tgaaaaaggc gctccattta tttcgcaaat
    25861 ccaatccgcc tttgctggaa tggctgcaat ctccgattcc ctatctggag cagtattcag
    25921 tggctgatca gattcgtgcg atctcgccgt taaccttctc tccgaagtca tgtatgtacc
    25981 attatctgaa tatggcgcgg ggaaattatc gggattattt gcaaggtgaa caggtgaaga
    26041 ttaaaaagta tttttacgtg ctgcgcccgc tgctggcctg tggctggatt gaacgataca
    26101 acagcatgcc tccgatggaa ttcgtagact tgctggagga attcattccg gctgataccg
    26161 aactttatca ggtgatcgag cttttgctgg agcgtaaaaa agcgggtgag gagctggata
    26221 tggagccgca gctttcggtg gtgaatgact ttattgaaca gcaaattgct tattttgaac
    26281 agaaggcgcc tttgcttcag catatggagg gcggacggga tcagcaattg gacgagatgt
    26341 tccgcgctgc ggtgaatgaa gtatggaaaa cataagcagg gaaggagaag tggagtatgc
    26401 acatcacgct aaaagcaacc ggaaacaatg ctgggatgat ttcgcatttg ctcgccaaga
    26461 acccttacaa tacgtatgat cgcacggaaa agggtgcacg tgtacgcatg gtgtacacca
    26521 cttttacaga ggaagaggca gaaatcgtca ttcaggcttc accagattca atagatttgg
    26581 tcaaaaacag tccggatagc tatgacatta cacaatatat taatgaccgg gagtttgtaa
    26641 ccagcagctt gttctgtacc tatattcgcg gcgcgcttgg cacagccctg aacggcaaac
    26701 ccaaggaaga ctatacagcg tgggtgacgc atccttttgc gctggagtta tcgtttgggc
    26761 ctgttgcgtc ggatttgccg gatgctgtgg tggagggact atttgcgccg ctgggctatc
    26821 aagtgaccat cgaacgaggt gaagcggatt attcttttca gctgaaaaat cgaagcaccg
    26881 tcagatatgt cacgctaagt ggccatcaga cggtgcaata tgcgctgcgt cagttattgc
    26941 tgttgattcc agtgttggat aattataagc actactatat tagcgaagaa gagtttgaca
    27001 agctgagacg ttacggtgaa ggctggctgc aagagcatcc gatgcgcgag ctcatcattc
    27061 gacgcacgct tcattttacc aatctgattg agcaatttga gcaatctgat tctgctgcta
    27121 cacagactga aaaacatgcg gtccaagaac aaaaccgtaa tcacgaacag gatcagcagc
    27181 aagatcagtc actggaggaa ggaaagcaac agcctgtaat gcggctaaat gagctgcggt
    27241 atcaagccat tatggatgtg attcgcaagc tgccccgaag acagaaaatc gtagattttg
    27301 gatcagggga agggaagctt tcggctcgga tggctcgaat gaagggcatt gaa
//
