LOCUS       NZ_CP086322            21107 bp    DNA     linear   CON 26-NOV-2024
DEFINITION  Streptomyces halobius strain 3_2 chromosome, complete genome.
ACCESSION   NZ_CP086322
VERSION     NZ_CP086322.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces halobius
  ORGANISM  Streptomyces halobius
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9239126)
  AUTHORS   Wen,Y., Zhang,W. and Liu,X.G.
  TITLE     Streptomyces nigrumlapis sp.nov.,an antimicrobial producing
            actinobacterium isolated from Black Gobi rocks
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9239126)
  AUTHORS   Zhang,W., Liu,X.G. and Wen,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2021) Northwest Institute of Eco-Environment and
            Resources, CAS, Chinese Academy of Sciences, Donggang West Road 320,
            Lanzhou, Gansu 730000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: GS De Novo Assembler v. FEB-2021
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 241.26X
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023277745.1-RS_2024_11_26
            Annotation Date                   :: 11/26/2024 03:43:17
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,438
            CDSs (total)                      :: 8,346
            Genes (coding)                    :: 7,837
            CDSs (with protein)               :: 7,837
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 509
            CDSs (without protein)            :: 509
            Pseudo Genes (ambiguous residues) :: 0 of 509
            Pseudo Genes (frameshifted)       :: 193 of 509
            Pseudo Genes (incomplete)         :: 418 of 509
            Pseudo Genes (internal stop)      :: 17 of 509
            Pseudo Genes (multiple problems)  :: 113 of 509
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:33:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8864205
            Orig. end                         :: 8885312
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP086322.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21107
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="indole"
                     /region_number="39"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /tool="antismash"
     cand_cluster    1..21107
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21107
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11107](-)"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11107)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     gene            970..1530
                     /locus_tag="K9S39_RS40270"
                     /old_locus_tag="K9S39_40440"
     CDS             970..1530
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091483.1"
                     /locus_tag="K9S39_RS40270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_40440"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_248868229.1"
                     /transl_table=11
                     /translation="MYAISLDDDGAELRPLEPWRAEEFLAHIDRGREFIGQHIPLPDRA
                     TDLESSRAYLQSYAEKTAADTGRLYGIWTDGKLVGGVLFRTMDVEQGTAEAGCWLEPSA
                     VGKGLVTRAVRVIIDWVVEERCIHRVEWLASAANEPSIAVARRLGMTKDGVLRESYLYR
                     GKRHDTEVWSVLAPEWRADRQVS"
     misc_feature    complement(1634..1647)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.76"
                     /tool="antismash"
     gene            1637..2311
                     /locus_tag="K9S39_RS40275"
                     /old_locus_tag="K9S39_40445"
     CDS             1637..2311
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1226: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123385.1"
                     /locus_tag="K9S39_RS40275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_40445"
                     /product="formylglycine-generating enzyme family protein"
                     /protein_id="WP_248868230.1"
                     /transl_table=11
                     /translation="MDMHAGNEMVAVPPGRVTLSDRRTQRSWSTELGPYRISAFPMTQA
                     QYAQCTGQRPSSAQGDRLPVEGVSWWDAVRFCNALSRSEGLAPVYRLHADAEGVEWEAS
                     ADGYRLPTEAEWEHACRAGTAGARYGRLDEVAWYRGNSGGRIHDVGGKPPNAWGLSDML
                     GNVWEWCWDIYDAEVYGSYRVLRGGGWFDEHWSCRASVRRRSHPTFQIDDVGFRVARSI
                     VR"
     gene            2543..2965
                     /locus_tag="K9S39_RS40280"
                     /old_locus_tag="K9S39_40450"
     CDS             2543..2965
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS40280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_40450"
                     /product="hypothetical protein"
                     /protein_id="WP_248868231.1"
                     /transl_table=11
                     /translation="MRGGTKQRLGTAAAVVGLVAAVAPASSASAAQAARCPVTAWGHTG
                     YYKCGTDLKAGYVDWNRDGRVDEVFVIAPDRTIWHTWAAAGGWKEMPGNGRADNMLGAA
                     ETGAPTRCVIVYVNKGYHYWQNCFYGGRWHTWKTTG"
     gene            complement(3173..>3615)
                     /locus_tag="K9S39_RS40285"
                     /old_locus_tag="K9S39_40455"
                     /pseudo=""
     CDS             complement(3173..>3615)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003983496.1"
                     /locus_tag="K9S39_RS40285"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="K9S39_40455"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="RAGSWRTLRVDVIGRRLAPADPLHGFHRAHPVPGTEWAAYYDELA
                     AAFGLTIEVTGPDFGTEPLLDTIADSSVLATFVGGPTRLVWPADHDLRRITVHDPTPVH
                     PHSLIRRSDNPHSRARHIARLSRLHTAGRVATPGHGRRSGRRA"
     misc_feature    complement(3241..3243)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3594..3851
                     /locus_tag="K9S39_RS40290"
                     /old_locus_tag="K9S39_40460"
     CDS             3594..3851
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS40290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_40460"
                     /product="hypothetical protein"
                     /protein_id="WP_406708104.1"
                     /transl_table=11
                     /translation="MCASYRLDHTAGDRVARTLSAWSVTSKATIAAMTALWGLLAGITC
                     PRTAIAIAGLLVLATPFPASPIRSRAAARAGIGAEPLKAD"
     gene            4392..5831
                     /locus_tag="K9S39_RS40295"
                     /old_locus_tag="K9S39_40465"
     CDS             4392..5831
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049572.1"
                     /locus_tag="K9S39_RS40295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_40465"
                     /product="sensor histidine kinase KdpD"
                     /protein_id="WP_248868232.1"
                     /transl_table=11
                     /translation="MWLLPPVLLAVCGAVIVWLTPSMARSQVAWIGAIATVAVAAAAGE
                     AARRARATDELRRQYAEREATLQQYLAEQEVETVRMAKETLPAAMAKLQQGVTPDEVLE
                     SVAQKSDVSPEFEVAHKAVLRYVLQAVAAEEDLRDSAQRAFVNIARRVQAIIHQQAQEL
                     REMEDRHGQDPEVFGDLLHLDHRTALVGRLADSIAVLGGARPGRQWQQNVPLFNVLRGA
                     MSRILDYQRVDLHSVAEVGILGRAVEPLIHALSELLDNSTRYSPPQTRVHLTATEIQTG
                     VAIEIEDAGIGLTDEARVRAERALAQHSTSGLDLDDLGEAPRLGLAVVGRLCHTHAFKV
                     SLRPSAYGGVRVVLIVPPDLITATPVPGGMVAKAATLPPPRHSVGPKRSVTAEEPTPTA
                     SPRSANGLPQRRRRTRAMAPRMQPKPAASTATDSKPPVSADSPPQAGMWLAAFQEGISG
                     ESRAESPADRPDGLSEKESER"
     gene            5886..6272
                     /locus_tag="K9S39_RS40300"
                     /old_locus_tag="K9S39_40470"
     CDS             5886..6272
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018540698.1"
                     /locus_tag="K9S39_RS40300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_40470"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_248869193.1"
                     /transl_table=11
                     /translation="MDWMLEDLASSVPQTRDVVVLSSDGLCMAQFGTDKDTADRLAAAC
                     AGLQSLSAAIATEFPHGNGQMKLVVIEVNGGFFYLMAAGAGAYLAVLADDDVDAGLMGE
                     RMRDLVARIGQHLTSPPRADRQVP"
     gene            6269..6640
                     /locus_tag="K9S39_RS40305"
                     /old_locus_tag="K9S39_40475"
     CDS             6269..6640
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016573506.1"
                     /locus_tag="K9S39_RS40305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_40475"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_248868233.1"
                     /transl_table=11
                     /translation="MSDPKEEQPKGWEEGAPERLYVIASGGNQPGQKTPLDMVTLIVTR
                     NGPSSSMQPELAAIVRICDYPLSVAEISAYLHLPVSVITVLLADLLESGHVEARAPIPA
                     TSLPDVELLEAVMHGLQNL"
     gene            6621..7244
                     /locus_tag="K9S39_RS40310"
                     /old_locus_tag="K9S39_40480"
     CDS             6621..7244
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018540696.1"
                     /locus_tag="K9S39_RS40310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_40480"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_248868234.1"
                     /transl_table=11
                     /translation="MDCKISEPVVGPRSEDVLPASVTTAVKVVIVGGFGVGKTTLVGSV
                     SEIRPLTTEETMTQAGVGVDDIAGIERKTETTVAMDFGRISLSDELVLYLFGTPGQQRF
                     WFLWNGLFEGALGAVVLIDTRRLEVSFDVIGRLEERGVPFIVAINAFPDGPTYPMSELR
                     VALDIPDSVPMIDCDARDRVSSRDALLTLMRYLHTLTTTPPEPR"
     gene            7376..8659
                     /locus_tag="K9S39_RS40315"
                     /old_locus_tag="K9S39_40485"
     CDS             7376..8659
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018540695.1"
                     /locus_tag="K9S39_RS40315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_40485"
                     /product="cytochrome P450"
                     /protein_id="WP_248868235.1"
                     /transl_table=11
                     /translation="MGLYEKLRAEHGPVAPILLDGDLPAWLVIGYREILEVAGTPSRFS
                     RDSRIWRWFKEGKVPPESPLLPMIAWQPVCLFLDGDERQRLRVAVTDGLERFSRRGIRR
                     HVTRFTHQLIDGFAYRGEADLADEFAEHLPMLVMTQLLGMPDEYGPRLVQASRDMVAGT
                     ETSVDSNEFIVKTLQQLVGRKRASPGEDITSWLIEHPSQLTDEEVWNHLRVILIAANET
                     TVNLLKSTLRMLLTDPRCHASLAGGQMTLPDVLEQVLWDEPPLMTIPGRWASVDTEVGG
                     QKVEAGDMLLLGLGAGNHDPAVRPDPAVSMHGNRSHLAFSSGPQECPGQDIGRAIADTS
                     IPEEELRWKSGWMTRHLTSLPVQFSARRSGASAESAGPGGVDAETERAATGSGSRSMDK
                     LLGPSPSTPVPGARLSWWRSLKAWLRRR"
     gene            complement(8736..9995)
                     /locus_tag="K9S39_RS40320"
                     /old_locus_tag="K9S39_40490"
     CDS             complement(8736..9995)
                     /NRPS_PKS="Domain: Aminotran_1_2 (34-389). E-value:
                     7.6e-46. Score: 148.8. Matches aSDomain:
                     nrpspksdomains_K9S39_RS40320_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003985360.1"
                     /locus_tag="K9S39_RS40320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_40490"
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="WP_248868236.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.1e-43, bitscore:
                     148.8, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 1.5e-05, bitscore:
                     23.0, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 8.9e-08,
                     bitscore: 30.7, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALSAATGSLFDDSQIQPAMLRDRSNIRWSAYPPDVIPLTAAEPD
                     FAGPPVVTDAMISSLADGYFPYAPPEGLSELREICSAVAKDRYGIGASPDRVVLTAGTA
                     AAIWGVVHLLCRKGDECILPDPVDMLFGQAIDAVGARRVYCPMDKRTGRLDPDRLASLI
                     TPRTALICLCNPHNPLGTVFAEETLRAIAETAGARRIPILSDEVWNEIVYPPAVHTSTA
                     SLDTANSQRIFTLTGLSKTFALPGLRMGFAVAPTAREAHDLQLTFQRLGAAYNLTPFAQ
                     VGAVAALRHGWPWRNAFLEHLQEMRDYCVERLNAFPGISCSRPDGTFVLFPDVTSSGLD
                     SQTMAEYLLEAARVAVVGGTTEWFGPAAEGNIRICYATSRGIMTEALNRMERALDRLSE
                     APVHRAENAVASAHGRLTGT"
     aSDomain        complement(8829..9893)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K9S39_RS40320_Aminotran_1_2.1"
                     /evalue="7.60E-46"
                     /label="K9S39_RS40320_Aminotran_1_2.1"
                     /locus_tag="K9S39_RS40320"
                     /protein_end="389"
                     /protein_start="34"
                     /score="148.8"
                     /tool="antismash"
                     /translation="DVIPLTAAEPDFAGPPVVTDAMISSLADGYFPYAPPEGLSELREI
                     CSAVAKDRYGIGASPDRVVLTAGTAAAIWGVVHLLCRKGDECILPDPVDMLFGQAIDAV
                     GARRVYCPMDKRTGRLDPDRLASLITPRTALICLCNPHNPLGTVFAEETLRAIAETAGA
                     RRIPILSDEVWNEIVYPPAVHTSTASLDTANSQRIFTLTGLSKTFALPGLRMGFAVAPT
                     AREAHDLQLTFQRLGAAYNLTPFAQVGAVAALRHGWPWRNAFLEHLQEMRDYCVERLNA
                     FPGISCSRPDGTFVLFPDVTSSGLDSQTMAEYLLEAARVAVVGGTTEWFGPAAEGNIRI
                     CYATSRGIMTEALNR"
     misc_feature    complement(9627..9629)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..11107)
                     /locus_tag="K9S39_RS40325"
                     /old_locus_tag="K9S39_40495"
     CDS             complement(10001..11107)
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_process="GO:0009820 - alkaloid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indole_PTase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF023417.5"
                     /locus_tag="K9S39_RS40325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_40495"
                     /product="tryptophan dimethylallyltransferase family
                     protein"
                     /protein_id="WP_283113315.1"
                     /sec_met_domain="indole_PTase (E-value: 1.2e-107, bitscore:
                     358.9, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRLPSESRISAGATFLDYGIATGTRLLDSAGMDVEQGEAVLRSM
                     LSSWGERQIKQRPEWHSDVCADGSPIEFSASFSDDGTQIRVLVEAVPDELSTLAAQKSA
                     LGLTQTLIDDFGAAGGRLAAVSDLFLPSEDPTGFAMMHAVDFSSTGRPEFKVYLNPNAN
                     NGMTRTERTQEALDRLGFGQAWESVSAYARRGFDLDRIVYLGLDLSDRPESRVKVYFRH
                     YDVVPADLDTCMEISTHHEPGLLGEFCRQLTGRAGELTDQPVVSNLTFTQAGGHAPVSA
                     TAYVPLWRYADSDSTLRDRICSVMADIGLPSTDYRSLLNHMARRPLSDGRGMHTYASVR
                     VQRGRPRMTTYWSSELYDRYPPARYQRG"
     misc_feature    complement(11109..11120)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     misc_feature    complement(11935..11948)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 20.57"
                     /tool="antismash"
     gene            12086..13325
                     /locus_tag="K9S39_RS40330"
                     /old_locus_tag="K9S39_40500"
                     /pseudo=""
     CDS             12086..13325
                     /NRPS_PKS="Domain: Beta_elim_lyase (156-340). E-value:
                     4.9e-08. Score: 24.5. Matches aSDomain:
                     nrpspksdomains_K9S39_RS40330_Beta_elim_lyase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1180: Decarboxylase, pyridoxal-dependent"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016573976.1"
                     /locus_tag="K9S39_RS40330"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_40500"
                     /product="pyridoxal phosphate-dependent decarboxylase
                     family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRPQLGASLSQLHHLLDATRLHATALLDGIDERPVVVTSAALAGD
                     WLTSTMDQNSHSSLDPAGQHLERETIAWLRTLFGLSDEHEGTFVSGATMSNTVGLAIAR
                     EWLGERLGISPAEAGVAALGPVRVLSGSPLSSIAKGLSMLALGRGALVTVPTLPHREAV
                     DPAALASSLQQADGPCVVVANAGTVNTVDFDDVRAIAALRDRYDFWLHADAAFGAFAAA
                     SPEHARLVAGLNLADSVCVDLHKWLNAPHDSAVQFTRRRDLQARAFQNAAAYLGLLGDI
                     PDPVHLTPENSRRLRALAAWFTLRAYGRDGHREIVERCVMARPYAGTGHRRHGGPAPAG
                     TRRP"
     aSDomain        12554..13105
                     /aSDomain="Beta_elim_lyase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K9S39_RS40330_Beta_elim_lyase.1"
                     /evalue="4.90E-08"
                     /label="K9S39_RS40330_Beta_elim_lyase.1"
                     /locus_tag="K9S39_RS40330"
                     /protein_end="340"
                     /protein_start="156"
                     /score="24.5"
                     /tool="antismash"
                     /translation="LPHREAVDPAALASSLQQADGPCVVVANAGTVNTVDFDDVRAIAA
                     LRDRYDFWLHADAAFGAFAAASPEHARLVAGLNLADSVCVDLHKWLNAPHDSAVQFTRR
                     RDLQARAFQNAAAYLGLLGDIPDPVHLTPENSRRLRALAAWFTLRAYGRDGHREIVERC
                     VMARPYAGTGHRRHGGPAPAG"
     misc_feature    13217..13219
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13521..13811)
                     /locus_tag="K9S39_RS40335"
                     /old_locus_tag="K9S39_40505"
     CDS             complement(13521..13811)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018537715.1"
                     /locus_tag="K9S39_RS40335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_40505"
                     /product="hypothetical protein"
                     /protein_id="WP_248868238.1"
                     /transl_table=11
                     /translation="MTWASWTTVGIHARPGRVRTEEAGTIEGDLTVHTTWSEGEAHVAV
                     QYTGSEDWFTMAGSPVPCDTEEASRNFHQAVVEAMRDGEEGGPSLRELFPL"
     misc_feature    complement(14170..14190)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.5"
                     /tool="antismash"
     gene            complement(14374..14550)
                     /locus_tag="K9S39_RS43245"
                     /old_locus_tag="K9S39_40510"
     CDS             complement(14374..14550)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS43245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_40510"
                     /product="hypothetical protein"
                     /protein_id="WP_406708192.1"
                     /transl_table=11
                     /translation="MTDAIKAYPTTLPGLTSSHILAGCGHWVQQECSDEVNRLLVDWLH
                     SLPAHSGRQHSPS"
     gene            complement(<14621..15238)
                     /locus_tag="K9S39_RS43250"
                     /old_locus_tag="K9S39_40515"
                     /pseudo=""
     CDS             complement(<14621..15238)
                     /NRPS_PKS="Domain: Abhydrolase_1 (58-160). E-value:
                     1.1e-26. Score: 85.9. Matches aSDomain:
                     nrpspksdomains_K9S39_RS43250_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.5"
                     /locus_tag="K9S39_RS43250"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_40515"
                     /product="alpha/beta fold hydrolase"
                     /pseudo=""
                     /sec_met_domain="PF00561 (E-value: 6.3e-21, bitscore: 74.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.2e-12, bitscore:
                     47.9, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQPVSRPTERNTRRPLTPSTSATAGRVTSPPEPAPEMKHRLVDA
                     PCGRIHVVEQGSGPLVLMVHGFPESWYSWRHQLPVIAAAGFRAVAIDVRGYGRSSKPLD
                     VAAYRMLAHVDDNVAVVHALGEETAVIVGHDWGSPIAANSALLRPEVFTAVGLLSVPYA
                     PRNGIRPTEVRPRFLRARIRADRVLRSTQPLSQCRPGLGRSRR"
     misc_feature    complement(14705..14707)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(14759..15064)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K9S39_RS43250_Abhydrolase_1.1"
                     /evalue="1.10E-26"
                     /label="K9S39_RS43250_Abhydrolase_1.1"
                     /locus_tag="K9S39_RS43250"
                     /protein_end="160"
                     /protein_start="58"
                     /score="85.9"
                     /tool="antismash"
                     /translation="PLVLMVHGFPESWYSWRHQLPVIAAAGFRAVAIDVRGYGRSSKPL
                     DVAAYRMLAHVDDNVAVVHALGEETAVIVGHDWGSPIAANSALLRPEVFTAVGLLSV"
     gene            complement(15385..16593)
                     /locus_tag="K9S39_RS40345"
                     /old_locus_tag="K9S39_40520"
     CDS             complement(15385..16593)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024945.5"
                     /locus_tag="K9S39_RS40345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_40520"
                     /product="CdaR family transcriptional regulator"
                     /protein_id="WP_248868239.1"
                     /transl_table=11
                     /translation="MWASQLKPVPGRPGFPSYQMNEVTMGEATTSDARGGVCLSERGGT
                     RDDGDQRAVLAELITRSLSDHTVGFRSFIERAGHAQVARLVEEALRNAVASGARPSDAE
                     HAPGRTTDELGDGVNGGGNGDNCVDLRRPASSQQARRALFSALTGEGAIPTGMLGQLSR
                     RADWPLPGRVRAIALRTRTDIHLVASALGDCLISAPEQEPCLLVPVTASPLADEKARLH
                     GVLRCRSAAVGHAVPLHDAAASVRWACRLLELVRPGVGPGGGVVFVDDHVSSLLLLQDK
                     SLLRALVARQLRPLAGLTPDRCARLEATLLAWLGGGGAPEIAKALSIHPQTVRYRMRQI
                     EKLFGSRLRDPRTRFEIQMALRSRLLLANAHRRSPERNRRARAGARPCRLLSTAPGADV
                     NGL"
     misc_feature    16859..16868
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.9"
                     /tool="antismash"
     gene            17069..17491
                     /locus_tag="K9S39_RS40350"
                     /old_locus_tag="K9S39_40525"
     CDS             17069..17491
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952184.1"
                     /locus_tag="K9S39_RS40350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_40525"
                     /product="YjbQ family protein"
                     /protein_id="WP_248868240.1"
                     /transl_table=11
                     /translation="MADTFKTRVIDVTTGSQETVYDLTRDCERFLQDSAQGQDGFLNVF
                     APHATMGVALLETGAGSDDDLLAALRKLLPADFPWRHRHGSPGHGRDHVLPALVPPHAT
                     LPVIGGRLALGTWQSVCLVDTNVDNPNRQVRLSFLG"
     gene            complement(18107..20239)
                     /locus_tag="K9S39_RS40355"
                     /old_locus_tag="K9S39_40530"
     CDS             complement(18107..20239)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1122: ATP-dependent
                     RNA helicase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018530188.1"
                     /locus_tag="K9S39_RS40355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_40530"
                     /product="DEAD/DEAH box helicase"
                     /protein_id="WP_248868241.1"
                     /transl_table=11
                     /translation="MTGAPEPLDRLHPGLVHHIVNTLGWSGLRPLQEEAIEPLLDSSDA
                     VLLAPTAGGKTEAASFPLLSKMATENWTGTSVLYVCPLKALLNNLLPRLETCTAWLGRT
                     AALWHGDVTQPRRKKILRERPDVLLTTPESLEAMLVSTNVDHRAFFSGLQAIVIDEVHA
                     FAGDDRGWHLLAVLERLERVVGRPVQRVGLSATVGNPEQLLTWLQGSGGGRRQARVVAP
                     HLRDEAPVLPPPGDIQLDYVGSMENAATVVAALHRGEKRLVFCESRRQVEKLGESLRAK
                     GVTTFLSHASLSVDERRRAEEAFADARDCVIVSTSTLELGIDVGDLDRVIQIDAPGTVA
                     SFLQRLGRTGRRPGTIRNCLFLAVDEEGLLAAAALLLLWSRGWVEPVTAPPEPRHIVAQ
                     QVLALCLQEHRVGDRLWHEWWGGLGPFGTSAEPIVHHLIDEGYLERDGGMLFIGPEAER
                     RFGYRHFMDLTAVFTAAPEFTVLAGRTEIGTTNPSLLTEEVMGPRRLLLAGRSWQVTYI
                     DWSRRRCFVEPVDGGGKARWGGAGAARGTSYELTRAAREILLGATPPVSLTRRADAALT
                     QVRGDRAELVHPDGTVIVRGGRDTNVRWWTWAGYRANATLTSTLTTVADPLQRPTDTCV
                     RLRDDLTAAEWKKATAVAADQLGLPAVDARALNGLKFSATLPPRLAEATLAARLADLDG
                     AVAVLKEPSRFTILGQ"
ORIGIN
        1 atgatcccgg tcccgatgac cgaggccggc ccggacatgg acgtcgtgga gcgcctcgtg
       61 gccgaggacc ccgccgtcaa gggcatctgg tgcgtcccga agtacagcaa cccgtccggc
      121 gtcagctaca gcgacgagac ggtggcgcgc ctggcccgca tggagacggc cgccccggac
      181 ttccggatct tctgggacaa cgcctacgcc gcccaccacc tcaccgacga gcccgtgcag
      241 atcgccgacc tcctcgccgc gtgcacagcg agcggcaacc cggaccgggc gttcctcttc
      301 ggctccacct cgaagatcac cttcgcgggc gcgggcgtcg ccttcttcgg ctcctcgccc
      361 gccaacgtga gctggctgac cgccaacaac tccaagcgct cgatcggccc cgacaagacc
      421 aaccagctgc gccacgtcct cttcctccgg gacgaggacg gcgtacgggc ccacatggag
      481 cgccaacgag ccctgctcca gcccaagttc gatgccgtcc agcgcatcct ggaagccgag
      541 ctcggcggca ccggcctggc cgagtggacc acccccaaag gcggttactt cgtcaccctt
      601 gaggtcatgg agggctgcgc cgaggatgtg gtgcgccgcg cggccgaggc gggcatcgtg
      661 ctgaccccgg ccggcgcgac ccacccgtac ggcgacgacc cccgcgacgc gacgatccgc
      721 atcgcgccca gctacccgag cctggccgag ctggagcagg cgatgctcgg tctgaccgtg
      781 tgcgtgcgtc tgtccggcta cgagaagatg ctcacgacct gagccgatgg tcccggcgcc
      841 ccggggaccg tcccggccat cggaccgccc cgccgtccac cacaccgcca cagacgcccg
      901 ggactccgcc cgtgagaaga tccgtgcgcg gtatgcggta ggcacggttt tcgacggtgg
      961 aggttggcga tgtacgcgat atccctggac gacgacggtg ccgagctgcg cccgctggag
     1021 ccatggcgcg ccgaggagtt cctggcccat atcgaccgtg ggcgggagtt catcgggcag
     1081 cacatcccgt tgccggaccg tgccacggac ctggagtcga gccgggcgta cctgcagtcg
     1141 tacgcggaga agaccgcggc tgacaccggg cggctctacg ggatctggac cgacggcaag
     1201 ctggtcggcg gagtcctgtt ccggacgatg gacgtcgagc agggcaccgc cgaggcgggc
     1261 tgctggcttg agccgtcggc ggtgggcaag gggctggtga cccgggccgt gcgggtgatc
     1321 atcgattggg tcgtcgagga gcggtgcatc caccgcgtgg agtggctggc ctcggcggcg
     1381 aatgagccca gcatcgccgt cgcccggcgg ctcgggatga cgaaggacgg cgtcctgcgg
     1441 gagagctacc tgtatcgggg caagcggcac gacacggagg tctggtcggt actcgcaccg
     1501 gagtggcggg cggacaggca ggtgtcctga cgccgccgta gttggcgagt cggcggcagc
     1561 agcgctgaag cggcccttgt tgacgttccc gaccgacacc gggacggaga tcacgccccg
     1621 gtaggatcgc ctgtccatgg acatgcacgc aggaaacgag atggtcgccg tcccgccggg
     1681 gcgggtgacg ctgtcggatc ggcgaacgca gcggagttgg tcgaccgagc ttgggcccta
     1741 tcggatatcg gcgttcccga tgactcaggc gcagtacgca cagtgcaccg gtcagcggcc
     1801 gagcagcgcg caaggcgacc gattgcccgt cgagggcgtt tcgtggtggg acgcggtccg
     1861 gttctgcaat gccctgtccc ggagcgaggg attggcgccc gtctatcgcc tccatgctga
     1921 cgccgagggt gttgaatggg aagcttccgc tgatggctac cggctcccga ccgaggccga
     1981 gtgggaacac gcgtgtcgtg ccggtacggc cggggcgcgg tacgggcggc tcgacgaggt
     2041 cgcttggtac cgcggcaatt cgggcgggcg gatccacgat gtgggcggca aaccccccaa
     2101 tgcctggggc ctgtccgaca tgctgggcaa cgtctgggag tggtgctggg acatctacga
     2161 tgccgaggtc tacggcagct atcgggtgct gcgtggcggc ggttggttcg acgagcactg
     2221 gagctgtcgg gcctcggtgc gacgccgtag ccacccgact ttccagattg acgacgtggg
     2281 gttccgtgtc gcgcgttcca tcgtgcggtg acgcacgccc tttgccatgg ctgcggcctt
     2341 ccgtccctgc ggagccaaag gagtgttatg ccgactcctg gccattctca gcagtcttat
     2401 ctcggcgttc cacctggatt cccatcgtgt gtggccgaaa gttgcgcaga cgccccgtac
     2461 ggcccgcgta atgctgtcgc acacgttcgg tgaaggacca aggcaagggc atgggcagac
     2521 cggcccggag ggtgggggac tgatgcgtgg cggtacgaag cagagactgg gaacggccgc
     2581 ggcagtagtc ggtttggtcg ctgccgtcgc tccggcgagc agtgccagtg ccgcgcaagc
     2641 ggcgaggtgt cccgttacgg cgtggggtca caccggctac tacaagtgcg gcaccgacct
     2701 caaggccggg tatgtcgact ggaaccgcga cggccgcgtc gatgaggtct tcgtgatcgc
     2761 gccggaccgg accatctggc acacctgggc ggcggcggga ggctggaagg agatgccggg
     2821 caacggtcgc gccgacaaca tgctgggcgc tgcggagacg ggcgctccga cccgctgcgt
     2881 catcgtctat gtcaacaagg gctaccacta ctggcagaac tgtttctacg gtgggcgctg
     2941 gcacacctgg aagaccactg ggtgagcggc cttcgtcggc acgccctggc cgagcatacg
     3001 gtcagggccg tggacccgga cccggccgcg tgcggtaaca cgacgggcag cggccaccgt
     3061 gccgagcccg cgcccccggc ccgcgcccgc gccaggccaa atgcgcacct gacgtatgca
     3121 cacctgacgc tacgtcactc gacgccaggc aatgccgcgt gaggagtgtg gatcagcgcg
     3181 ccgtccactt cggcgtccat gtcccggcgt cgcgacgcgt ccggctgtgt ggagccgaga
     3241 taatcgcgcg atgtggcgag cgcgggaatg cggattgtcg ctgcgccgga tcagtgagtg
     3301 cgggtggacg ggcgtcgggt cgtgcacggt gatgcggcgc aggtcgtggt cggcgggcca
     3361 gaccaggcgc gtcggtccgc cgacgaaggt ggccagcacc gaggagtcgg cgatcgtgtc
     3421 gaggagcggc tcggtgccga agtcggggcc ggtcacctcg atggtgagcc cgaacgcggc
     3481 ggcgagctcg tcgtagtacg cggcccactc ggtaccgggg acgggatgcg cgcggtggaa
     3541 accgtgcagc ggatccgccg gtgcgagccg tcggccgatc acgtcgacgc gcagtgtgcg
     3601 ccagctaccg gctcgaccac accgcagggg accgggtcgc ccgcaccctg tccgcgtggt
     3661 cggtcaccag caaggccacc atcgcggcca tgaccgccct gtggggtctg ctggccggca
     3721 tcacctgccc ccgcaccgcc atcgcgatcg ccggtctcct cgtcctggca acgccgttcc
     3781 ccgcttcccc gatacgatca cgcgccgcag cacgagcggg aattggagcg gagcccctga
     3841 aggccgactg aggccgggcc gccggtctgc gtgtagcgtc ctttggccca cttcgccgcc
     3901 ggggcgggga gatttcggtt actgcttgac gtcacgtcag ttgacgtgca gcaacgcgac
     3961 tttgaccaag cactgcccgc aattccaatg agtgcccagg gctaaacgat tctcctgaat
     4021 ttcgcacatg agtgcattca tgtgttatat gcattcgggc cgcaaagcca ctgcgacctc
     4081 gctatgctcg ctgtcgcgca gcgagttgtg gcgattacca cacgtcgccg ctggctgtcg
     4141 tggtgccgcc gatcgcacgg aggtccgggc gtcctgggac ccggccccat gcgcggaacg
     4201 ccgccttgga atgtgctgcg gccaagcaat ggtgagcgcg acccgacggt cgtcgatctt
     4261 gttcgcgcgg cccttccccg gtgcccatat acgccatgta tgccgccctg tccctattcg
     4321 ttcatgctct gaggatgccg atggttcgtg ctggttcgtc acccggaggg tcggggtccg
     4381 cctccacccc aatgtggctg ttgccacccg tactcctggc cgtgtgcggg gcggtgatcg
     4441 tgtggctgac gccctcaatg gcccgttccc aagtcgcctg gatcggcgcc atcgcgacgg
     4501 tggcagtggc cgccgccgcc ggggaggcgg cgcgccgggc acgcgcgacc gacgaactgc
     4561 gcaggcagta cgccgagaga gaggcgaccc tgcagcagta tctggccgag caagaggtcg
     4621 agacggtgcg gatggccaag gagacactgc ccgcggccat ggccaagctg cagcaaggcg
     4681 tcacgcccga tgaggtgctg gaaagcgtcg cccagaagtc cgacgtcagc cccgagttcg
     4741 aagtcgcgca caaggcagtg ctgcgctacg tcctccaggc cgtggcggcc gaggaagacc
     4801 tgcgtgactc cgcccagcgg gccttcgtca acatcgcccg ccgtgtccag gccatcatcc
     4861 accaacaggc ccaggaacta cgggagatgg aggaccgcca cggccaggat ccggaagtct
     4921 tcggcgactt gctgcacctc gaccaccgga cggcactcgt cggccggctc gcggacagca
     4981 tcgcggtact cggtggggcc cggccgggtc gtcaatggca gcagaacgta ccgctgttca
     5041 acgtgttgcg cggtgcgatg tcccgcatcc tcgactacca gcgtgtcgat ctgcactccg
     5101 tggccgaggt cggcattctc ggacgcgcgg tcgagccgct gatccacgcc ctgtccgagc
     5161 tgctggacaa ctccacgcgc tattcaccgc cgcagacccg tgtccatctg accgcgacgg
     5221 agatccagac cggtgtggcc atcgagatcg aggacgccgg gatcggtctg accgacgaag
     5281 cccgcgtccg cgccgagcgt gccctggcac agcactccac cagcgggctc gacctcgacg
     5341 acctgggtga ggcgccgcgg ctcggcctgg ccgtggtcgg ccggctctgc cacacccatg
     5401 ccttcaaggt ctccctccgt ccgtccgcgt acggcggtgt acgcgtcgtc ctgatcgtcc
     5461 cgccggacct gatcaccgcg accccggtgc ccggtgggat ggtggccaag gccgccaccc
     5521 tgccgccgcc ccggcacagc gtcgggccga agcgctcggt gaccgccgag gagccgacgc
     5581 ccaccgcttc gccgcgcagc gccaacgggc tcccgcagcg tcggcgccgt acgcgggcca
     5641 tggctccccg catgcagccg aagcccgcgg cctccaccgc cacggactcc aagcccccgg
     5701 tgtcagcaga ttcaccccca caggccggaa tgtggctggc cgccttccag gagggcatct
     5761 ccggcgagtc ccgagctgaa tccccggcgg atcggcccga tggtctgagc gaaaaagagt
     5821 ccgagcgata actgagtcgt taagtaagga tgagtaagta agtggtgaca cagcagcggc
     5881 tcaatatgga ctggatgctc gaagacctgg catccagcgt tccgcagacc cgtgatgtcg
     5941 tggtgctgtc ctcagacggc ttgtgtatgg cgcagttcgg tacggacaag gacaccgcgg
     6001 accgcctcgc cgcagcctgc gccggactgc agagcctgtc ggcggccatc gccacggaat
     6061 tcccgcacgg caacgggcag atgaagctcg tcgtcatcga agtcaacggc ggcttcttct
     6121 atctgatggc ggccggcgcc ggagcgtatc tggcagtgct ggccgacgac gatgtggacg
     6181 ccggactcat gggagaacgc atgcgggacc tggtcgcccg gatcggtcaa cacctcacca
     6241 gcccgccgcg ggccgaccgg caggtcccat gagcgacccg aaagaggaac agcccaaggg
     6301 ctgggaagag ggcgctccgg aacggctcta cgtcattgcg tccggcggga accaacccgg
     6361 ccagaaaacc cccctggaca tggtcacgct gatcgtcacc aggaacgggc ccagttcgag
     6421 catgcagccc gaactcgccg ccatcgtccg catatgcgac taccccttgt ccgtcgccga
     6481 gatctccgca tatctccatc tgccggtcag cgtgatcacg gtattgctcg cggatctgct
     6541 ggagagcggc catgtcgaag cccgcgcacc gatcccggcc acgtcgttgc ccgatgtcga
     6601 acttttggag gcggtgatgc atggactgca aaatctctga acccgtcgtc ggtccccgca
     6661 gtgaagacgt tctgccggcc tcggtcacca cagcggtcaa agtggtgatc gtcggcggct
     6721 tcggggtcgg gaagaccacc ctcgtcggat cggtcagtga gatccgtccg ctgacgaccg
     6781 aggagaccat gacgcaggcc ggtgtcgggg tggacgacat cgccggaatc gagcgcaaga
     6841 ccgaaaccac cgtggcgatg gacttcggcc ggatcagcct cagtgacgaa ctggtgctgt
     6901 atctgttcgg cactccgggc cagcagcgct tctggtttct gtggaacggc cttttcgaag
     6961 gcgcgctggg ggcggtggtc ctgatcgaca cccgtcggct ggaagtcagc ttcgatgtga
     7021 tcggccgact tgaggaacgc ggtgtgccgt tcatcgtcgc catcaacgcc tttccggacg
     7081 gccccacata cccgatgtcc gagctccgcg tcgccctgga catccccgac tccgtaccca
     7141 tgatcgattg cgacgcccgc gaccgtgtct ccagccgcga tgccctgctg accctcatgc
     7201 gttatctgca cacccttacc accacacccc cggagccccg gtgacctcct cttcctccag
     7261 tcagccccgc accacctccg caaccgagcc gcctccggag tgcccggcgc acgcgaaatt
     7321 cggaaaccct gacggactgg cacggctttt cgggcctgaa gcggccaagg atcccatggg
     7381 tctgtacgag aagctgcgcg ccgaacacgg acctgtcgcg cccatcctgc tggacggaga
     7441 cctcccggcc tggctcgtca tcggctaccg cgagatcctt gaagtcgccg gtacgccctc
     7501 ccggttcagt cgtgattccc gcatctggcg ctggttcaag gaaggcaaag taccgccgga
     7561 atccccactg ctcccgatga tcgcctggca gccggtctgc ttgttcctgg acggcgacga
     7621 acgccagcgg ttgcgcgtgg cggtcactga tggactggaa cgcttcagcc gccgtggaat
     7681 tcgacgccat gtcacgcgct tcacccacca gttgatcgat ggcttcgcct accgaggaga
     7741 agcggatctg gccgacgagt tcgcggaaca tctgcccatg ctcgtcatga cgcagctgct
     7801 gggaatgccc gatgaatacg gtccgcggct ggtccaagcc agcagagaca tggtggcggg
     7861 caccgagacg tcggtggaca gcaacgagtt catcgtgaag acgctccagc aactcgtggg
     7921 gcgcaagcgc gccagccctg gcgaggacat cacgtcctgg ctgatcgagc acccctctca
     7981 gctcaccgac gaagaggtct ggaatcacct gcgggtcatc ctcatcgccg cgaacgagac
     8041 caccgtcaat ttgctcaaga gcaccctgcg gatgctcctc accgaccccc gttgccatgc
     8101 gtcgctggcc ggcggtcaga tgaccctgcc cgacgtgctg gagcaggtgc tgtgggacga
     8161 accgcccctg atgaccatcc ctgggcgctg ggcatccgtg gacacggagg tcggtggtca
     8221 gaaggtcgag gcgggggaca tgctgctgct cggtctcggc gccggaaacc acgacccggc
     8281 cgtgcgcccc gaccccgcgg tttccatgca cggaaaccgt tcccacctcg ccttcagcag
     8341 cggcccgcag gagtgccccg gccaggacat cggccgcgct atcgccgaca ccagcatccc
     8401 cgaggaggag ctgcgctgga aatcgggctg gatgacgcgg catctgacaa gcctgccggt
     8461 gcagttcagc gcgcgtcggt ccggtgcttc cgctgaatcc gccggtccgg ggggagttga
     8521 cgcggagact gagcgggccg ccacggggag cggctcaagg tccatggaca agctcctcgg
     8581 tccgtcccct tcgactccgg ttccgggtgc acgcctgtcc tggtggcgct cgctgaaggc
     8641 atggctgcga aggcggtagc ccggcgctcc gttgtggagg gagcgcccag aagcctttcc
     8701 cggtcaggaa tgtcagccgg gcattgctcc ctccatcagg tgcccgtcag acgcccgtgt
     8761 gcggaggcaa ccgcattctc ggctctgtgc actggagctt cggaaaggcg atccaaggcc
     8821 ctttccatgc ggttcaatgc ctccgtcata atcccccggg aagtggcata gcatatacgg
     8881 atattgcctt cggcagccgg accgaaccac tcagtggtgc cgcccaccac tgcgacccga
     8941 gccgcctcca ggaggtactc ggccatcgtc tggctgtcca gcccgcttga cgtcacatca
     9001 gggaacagga cgaatgttcc gtcgggacgg ctgcacgata ttccggggaa cgcgttcagc
     9061 cgttccacgc agtagtcccg catctcctgc agatgctcca agaaggcatt tctccagggc
     9121 cagccatgac gtagcgccgc cacagcaccg acctgggcga agggcgtcag gttgtacgca
     9181 gcgccgagac gctggaaggt gagctggaga tcgtgcgcct ctcgtgcagt gggggcgacc
     9241 gcgaatccca ttctcagacc gggcagtgcg aaggtcttgg agagcccggt caacgtgaag
     9301 attctctgac tgtttgcggt gtccaggctt gccgtgctcg tgtgcacggc aggcgggtac
     9361 acgatctcgt tccagacctc gtcggagaga atcggtatac gtcgcgcacc tgctgtctcg
     9421 gctatcgcac ggagcgtctc ctccgcgaag accgtaccga gtgggttgtg cggattgcac
     9481 aggcagatca gtgcggtgcg cggcgtaatc agagaggcca gtcggtcagg gtcaagacgt
     9541 ccggttctct tgtccatcgg gcaatagacc cgccgggccc ctacggcatc gatggcctgc
     9601 ccgaacagca tgtccaccgg atccggtaaa atgcactcgt cgcctttccg gcacagcagg
     9661 tgcaccacac cccagatcgc cgctgccgtg ccggcggtca gcaccacgcg atcgggactc
     9721 gcgccgatcc cgtaacgatc cttcgccacc gcggagcaga tttcccggag ttcgctgagc
     9781 ccctcagggg gcgcgtaggg aaagtagccg tcagcgagag acgatatcat cgcatccgtg
     9841 accaccggag ggccggcgaa atcgggttcc gctgcggtca gcgggatgac gtcgggtgga
     9901 taagcgctcc acctgatatt tgatcgatcc ctcagcattg cgggctggat ttgcgagtca
     9961 tcgaacagcg atccggtcgc agccgaaagc gccatgttgg tcaccctctc tgataacggg
    10021 caggcgggta tcggtcgtac agttccgagg accagtaggt ggtcatgcgg ggacggccgc
    10081 gctgcacccg tacagatgcg tacgtgtgca tcccgcgccc gtccgacagt gggcgccggg
    10141 ccatatggtt cagcagtgac cggtagtcag tactggggag accgatatca gccatgacgg
    10201 aacagattcg gtcccgtagc gtgctgtcgc tgtccgcgta tctccacagc gggacgtatg
    10261 ccgtggcgga tacgggggca tgcccgccgg cttgcgtgaa ggtcagattg ctgacgacgg
    10321 gttgatccgt cagctcaccg gccctgccgg tcaactgacg gcagaattcg cccaggaggc
    10381 cgggctcatg gtgggtggat atctccatgc aggtgtcaag gtctgctggg acaacgtcat
    10441 agtgacggaa atagaccttg acgcgcgact cgggacggtc gctcaggtcg aggccgaggt
    10501 agacgatcct gtcgaggtcg aatccccggc gagcgtatgc ggaaaccgac tcccatgcct
    10561 gaccgaatcc caagcgatcc agggcctcct gcgtccgctc ggtgcgggtc atgccgttat
    10621 tggcgttcgg gttcagatag accttgaact caggccttcc ggttgatgag aagtcaacgg
    10681 cgtgcatcat ggcgaaaccc gtcggatctt cgctcggcag gaacaaatcc gataccgccg
    10741 ccaaccggcc gccggcggcg ccgaagtcat cgatcaatgt ctgcgtcagg ccgagtgccg
    10801 atttctgcgc ggccagcgtg ctcagctcgt ccggcacggc ctccacgagc acccggattt
    10861 gcgtaccgtc atccgaaaag gaggcggaaa actcgattgg cgaaccgtca gcgcatacat
    10921 ccgagtgcca ttcagggcgc tgtttgatct gcctttcccc ccacgacgaa agcatgctgc
    10981 gcagaaccgc ttccccctgt tcgacgtcca tgcccgcact gtcaagcaga cgtgtgccgg
    11041 tggcgatccc gtagtccaag aaggtcgcac ccgcagatat ccgtgactcc gacggcagac
    11101 gcaacatggc gttcctttcc cttgcttcac cggttctcgc cgtacgcgtg cgcttgttcg
    11161 ccagtcgatc ggccagtacc aacaggtcgg atactcctgt ctgccactcc ttcaggcgcg
    11221 atagcctgat cacttcaccc ggtcgcgccg cagcccctgc gctcgctgcg aggattaccc
    11281 ggagactgac ctctgtattc cccagcagat gccgtgttcg tggtcatatg cgggttatcg
    11341 gactcatgga cggaaaagac cctgatggta cacctgatgg gtttgatcgt ctatcgcttt
    11401 ccctggatcc tgcgtttttg cattatcagt aacggagatc cctccgggcc gatagccgcg
    11461 cgccgggggg ctggtgaggc attccccgac agtgacatgc gcccatgcct gatgcatgtg
    11521 caggccgtca cccagagaga cagggaaagt ctcatcagct cctgacatcg ggtcaatacc
    11581 tggcggggga tcggttaagg ggactcggca tagcggcata gctggcgggc ggtacggcgc
    11641 atcggacgga taaattagcg tgcacgttcg gagttgttcg gagccgttcg ggggctttcg
    11701 gagtccttct ctgccggtgc cgagggtgcc gggggccggg gcagggctca ggccgggggc
    11761 cggggcagga ggccggttca cacgaacgcc gcccaccggg ccaggagcag tccttgcggc
    11821 gtcgcccact ctcccagacg cgactgtcct cgacgctgcc cactctcccg gcgccctgtc
    11881 cagctgttcg cagcccatac ccgggcccat ccacaccggt ccacttgtcc acaattggat
    11941 tcggcccacg cagccccgct ctgtctgacg tggtcccgga ccagccccgt cgtccccatt
    12001 tgctgcaccg tccccgctgg acgcaccgtc ctcactggca gtaccgcccc caaccaccgt
    12061 cccaagtccg atgatcggaa gcatgatgcg ccctcaactc ggcgcatctc tctcccagtt
    12121 gcaccatctc ctcgacgcca ctcgtttgca cgccacagcg ctcctcgacg gcattgacga
    12181 gcggcccgtc gtcgtgacct ccgccgcgct ggccggtgac tggctgacct caaccatgga
    12241 ccagaactcc cactcatcgc tcgacccagc gggtcagcat cttgagcgcg agacgatcgc
    12301 atggctgcga accctgttcg gcctgtcgga cgagcacgag ggcacattcg tcagcggcgc
    12361 caccatgtcc aacacggtcg gtctggcgat cgcccgggaa tggctcggtg agcggctcgg
    12421 catctcgccg gccgaggccg gagtggcggc tctcggcccg gtgcgggtgc tgtcgggcag
    12481 cccgctttcg agcatcgcca agggcctgtc gatgctcgcc ctgggccgtg gcgcactggt
    12541 cacagtgccg acgctgccgc atcgggaggc ggtcgacccg gcagcgctgg cgagttccct
    12601 acagcaggcg gacggcccct gcgtcgtggt ggccaatgcc ggcacggtca acactgtcga
    12661 cttcgacgat gtgcgtgcca tcgccgcact ccgtgaccgc tacgacttct ggctgcacgc
    12721 ggacgcagcc ttcggtgcgt tcgccgccgc atccccggaa cacgcgcgcc tcgtggcggg
    12781 tctgaacctg gccgactcgg tctgtgtgga cctgcacaag tggttgaacg caccgcacga
    12841 cagcgccgtc cagttcacac gtcgccgcga cctccaggcc cgcgcgttcc agaacgccgc
    12901 ggcctacctc gggctgctgg gcgacatccc cgatccggtc catctcaccc cggagaactc
    12961 ccgccgcttg cgcgcgctcg cggcatggtt caccttgcgc gcctacggga gggacggtca
    13021 ccgcgagatc gtcgaaaggt gcgtgatggc ccgtccgtac gctgggacgg gccatcgacg
    13081 ccatggcggg cctgcgcctg ctggcacccg tcggccttga cgtcgtctgc atcacgccca
    13141 ccgacgaccc gacgccggaa cggctcgccg cactcgccga cgaactgtcc gaggaggtct
    13201 tcctcacgcc gaccgtttac gccgaagtcc cagcactcag ggccgcgttc agcaattggc
    13261 gcactggcga ggccgacacc gcgcggatcg tccaggctct ggagaatgcg ctccgaaagc
    13321 ggtgaatcgc gctctgcgag ggatgaatag cgctttgcga ggggagcgcg ctttgcgtgg
    13381 gataacggaa acgcacgctg gtcggtacac cagggtaccg attccggcac ctggccagct
    13441 tccccgcaag cgccccgcac ggacgagatt ccagcacctg cgacgcgccg caggcggccc
    13501 catcctcctc gctgcgggcc ctacagaggg aagagctcgc gaaggctcgg cccgccctct
    13561 tccccgtcac gcatggcctc cacaaccgcc tggtgaaaat tgcggctggc ttcctccgtg
    13621 tcacagggga cggggctgcc ggccatggtg aaccagtcct ccgagccggt gtactgcacc
    13681 gctacgtggg cctcgccctc cgaccaggtc gtatggacgg tcaggtcgcc ttcgatcgtt
    13741 ccggcctctt ccgtacggac cctaccgggg cgtgcgtgga tcccgacggt cgtccaggat
    13801 gcccaggtca tgatgctccc cctagaggac gggggccgcg gccggcggcc gggcgcgatg
    13861 ccttaagtct gacactggca gcaagcggcc gcagggcatt gacaggcgga tttctgcttg
    13921 tagtcgatgc gtcacgccga gggaacggcc cgcgcctggc cgccacggct tacggccgga
    13981 ttccgaaggt ggcggaccat acaacaatgt catcactcct atacgaaggg tgatcgaggc
    14041 cgaagcccga aacgcagtga agaaatccga ttcccgatcc accagggcca ggagccgcag
    14101 actccttaac atagccagca tttccccaca tctctgccgg tctgccgcta cttcaactac
    14161 ttcaatagtt aatcgtcaaa tgaacccaag ctttaagctt caatcctcaa gcttcgaacc
    14221 tcgaacccaa acctcgaacc caaacctcga acttcgaacc tcgaacttcg acggagggta
    14281 gcgtcggcat caccgttccg ttcaatggcc accggatgcg tcagctacct caatctcggc
    14341 tgacacctca cggcggaaat ctcggctgac atctcacgac ggagagtgtt gccgccccga
    14401 gtgggccggc agcgaatgca gccagtcgac caggagccgg ttgacctcgt cgctgcattc
    14461 ctgctgcacc cagtgcccac aacctgccag gatgtgcgag gaagtcaggc ccggaagggt
    14521 ggtggggtac gccttgatgg cgtcggtcaa ccacatcgtg ggcgcgtcga actccccgcc
    14581 gatgaacagc gacggctggt tgatcggcgc cccgtcccat gcggcgagat ctacccagtc
    14641 ccggtcgaca ttgcgatagc ggttgagtgc tccggagaac cctgtccgct cgaattcgtg
    14701 cgcgtaaaaa tcgaggtcgg acttccgtcg gccggattcc gttccgaggt gcgtagggaa
    14761 cgctgagcag ccctacggcg gtgaagactt cgggcctcag cagcgccgag ttggcggcga
    14821 tgggcgagcc ccagtcgtgg cccacgatca ccgccgtctc ttcgccgagg gcgtgcacga
    14881 ccgcgacgtt gtcgtcgacg tgagccagca tccggtaggc cgccacgtcg agaggtttcg
    14941 atgaacgtcc gtagccgcgc acgtcgatag cgacggcacg aaagcccgcc gccgctatga
    15001 ccgggagctg gtggcgccac gaataccacg actcgggaaa accgtgaacc atcagaacga
    15061 ggggaccgct gccttgttcc accacgtgga tacgtccaca aggggcgtcc acgagccggt
    15121 gcttcatttc cggagcgggc tcgggcggcg acgtcactcg gcctgctgtt gccgacgtgg
    15181 acggagtgag ggggcgacgg gtgttccgtt cggtcggccg gctgacgggc tgcaacatac
    15241 acgtcctcct tgagcgacag caatgtgccc ggcggtcacg tcgagggcag ggcccgcccg
    15301 tgaggccgcc cgctggcggc gcggcgacct gccgacacca tgcgacggta agtcaaccgt
    15361 ccatcagcga ccagcctcgc cggttcacaa gccattcacg tcggccccgg gtgccgtcga
    15421 caggagtctg cagggccgcg ctccggcccg tgcacggcga ttgcgttccg gggagcgacg
    15481 atgcgcgttc gccagcaata gacggctccg gagcgccatt tggatttcga accgggtacg
    15541 cgggtcacgc agccgggatc cgaacaactt ctcgatctga cgcatccgat aacgcaccgt
    15601 ctgcggatgg atactgagtg ccttggcgat ttccggcgct ccgccaccac ccagccatgc
    15661 cagcaacgtc gcctccaaac gcgcgcaccg atccggtgtg agccctgcga gtggacgaag
    15721 ctggcgggcg acgagggcgc ggagcaacga cttgtcctgg aggagaagga gagacgacac
    15781 atggtcgtcg acgaacacca ccccgccacc gggcccgacg ccaggccgca ccagttccaa
    15841 cagccggcag gcccagcgta cggaggcggc ggcgtcatgg agcggaacag cgtgccccac
    15901 cgcggcagag cggcaacgca gcactccgtg gagcctggcc ttctcgtcgg cgagcgggct
    15961 ggccgtcaca gggaccagca ggcacggttc ttgctcaggt gcgctgatga ggcagtcgcc
    16021 cagcgcggac gccaccaggt ggatatcggt gcgggtcctg agcgcgatgg cccgcaccct
    16081 cccgggcagc ggccagtcgg cgcgacggct cagttggccg agcatcccag tggggatcgc
    16141 cccctcaccg gtcagcgcgg agaacaaggc ccggcgtgcc tgttgggatg atgccggccg
    16201 acgcaggtct acgcagttat cgccattccc gccgccgttg acgccatcac ccaattcgtc
    16261 ggtcgtgcgg ccaggcgcgt gttcggcgtc cgacggccgc gccccggagg ccacggcgtt
    16321 gcggagggcc tcctccacca gccgtgcgac ctgtgcgtgt ccggcccgct cgatgaagct
    16381 cctgaaaccc accgtgtggt cggagagcga tcgcgtgatc agttccgcga gtaccgcgcg
    16441 ctggtcgccg tcatcgcgcg tgccgccccg ctccgacagg caaacgccgc cgcgtgcgtc
    16501 actcgtagtt gcctcaccca tagtgacctc attcatctgg tagctgggaa acccaggccg
    16561 ccctgggacc ggcttgagtt gcgacgccca catcggccgt cccgcgtccg ccgccgcact
    16621 ccgtcggccg agccgctgtc ggcggcgaga aggtctccat cccgttgctt gcgcaacgat
    16681 gaggcccgac cgtatcgagc cgagcaaccc gccgcccggg gtccgttgat cgattcgctc
    16741 cgccattttg ttctacctca cggggcaagt gcctacagca cctgacagag atccgtcata
    16801 tttgggggag agtttgcctg aatcgaagcc tcactagaac gttcctgacg ccagaattcg
    16861 ttttgtgacg gcccgaggcg ctacccggcc agcgtcgggc cccaagccac tctcccgcca
    16921 cctgaaggcg ttcaggggtc aggagatcat acgcggaagc aaattccgaa ccggctgatc
    16981 gactcctcgg ccgccccggg accgggctgc gcaacggggg acgatcgcaa aacgacgctg
    17041 tgccggtggt gtctggcacg atcaagtcat ggctgacacg ttcaagacgc gagtgatcga
    17101 cgtgaccacc ggctcacagg agacggtcta cgacctgacc cgagactgtg agcgcttcct
    17161 ccaggattcg gcccaggggc aggacggatt cctgaacgtt ttcgcacccc acgcgaccat
    17221 gggcgtcgca ctgctggaaa ccggcgcggg aagcgacgac gacctgctgg cggccctccg
    17281 gaaactactc ccggccgact tcccctggcg ccacaggcac ggcagccccg gacacgggcg
    17341 ggaccatgtg ttgcctgctc tggttccgcc gcatgccacg cttcccgtca ttggggggag
    17401 gctggcgctg ggcacttggc agtccgtctg cttggtggat acgaatgtcg ataatccgaa
    17461 ccggcaggtg cggttgagct tcctcggtta gggcgcccct tcggtgggac tgcagaggcg
    17521 atgttcggcc gtaccaagtg atcagcggag cgccgttggg ggactgtctc ggattcgtcg
    17581 gccgccatcc gcctgggacg cgacccgcgc ggcctacgag gactctccga tggtggagcg
    17641 cagctacacc gcggcgctgt cggccgccaa tgagaaccct ggcgggccct ggcggacacc
    17701 gttacgcggc accccacctg gcgtcctgtg ccggtaggcc agacgccacc ccggtgatcc
    17761 acagctcacc atgccatgcg ggtcgccggc cgcggctcgc gcagtggtaa cgctcgatct
    17821 cgaccagcgc gtgccgacgg cagggtggcc cggggagagc cgggaacttg gatgtcggcg
    17881 atgagggcaa gggctgagcg aaggccgcgg tggtgtgagc ggacgcggcg gaacagtgcc
    17941 ggtgaccgga acacgtcgtg gccaggccag ggttggtggg aagtttctca gctacgggtt
    18001 gcgggtggga cctggcgggc atgcaggccg acctggcgtt ctgaatgcgg ctcgggaaag
    18061 aggtgattgt gtgtgctgac atggcccggg tcgtatgcgg cacaggtcac tggcccagaa
    18121 tcgtgaacct cgaaggttct ttgagcacgg ccactgctcc gtccaggtcg gcgaggcgtg
    18181 cggcaagagt ggcctccgcg agtcggggcg gaagcgtggc gctgaacttc agcccgttca
    18241 gggcacgcgc gtcgaccgct ggcagaccca actgatcggc ggcgaccgct gtggccttct
    18301 tccactccgc ggccgtcaag tcgtcgcgga gcctcacgca tgtgtcggtg ggacgctgaa
    18361 gggggtcagc gaccgtggtg agcgtgctgg tgagcgtggc atttgcccgg tagcctgccc
    18421 aggtccacca gcgcacattg gtgtcgcgtc cgccgcgtac gatcacggtc ccgtcggggt
    18481 gtaccaactc tgccctgtcc ccgcggacct gggtcagtgc ggcgtcggcg cgccgagtga
    18541 gggataccgg gggagtggcg ccgagcagta tctcgcgcgc cgcgcgtgtc agttcgtagg
    18601 aggtaccacg agcagcacct gcgccgcccc agcgtgcctt gccgccaccg tctaccggtt
    18661 cgacgaagca gcggcgtcgc gaccagtcga tatacgtcac ctgccagctg cgcccggcaa
    18721 gcagcagccg tctgggaccc atcacttcct cggttagtag ggaggggttg gtcgtgccga
    18781 tttcggtgcg gcccgcgagg actgtgaatt cgggagcagc ggtgaacacg gccgtgaggt
    18841 ccatgaagtg tcggtagccg aagcgccgtt ctgcctcagg gccgatgaac agcatcccac
    18901 cgtctcgctc caggtaccct tcgtcgatca gatggtgcac gatcggctcg gccgaggtgc
    18961 cgaagggacc gagaccgccc caccactcat gccagagccg gtctcctacc ctgtgctcct
    19021 gaaggcatag cgccaacacc tgctgggcga cgatgtgccg gggctcgggc ggcgccgtca
    19081 ccggctccac ccagccacgc gaccacagca ggagcagagc ggcagcggcg agcagccctt
    19141 cctcgtcgac cgcgagaaaa aggcagttgc ggatggtgcc gggccgtcgg ccggtgcggc
    19201 cgagccgttg gaggaacgag gccacggtgc cgggcgcatc gatctggatg acgcggtcca
    19261 agtcccccac gtcgatgccg agttccagtg tgctggtgga gacgatcacg cagtcccgcg
    19321 cgtcggcgaa cgcctcctcc gcccgccgcc gttcgtccac cgacaaagat gcgtgggaca
    19381 ggaaggtggt cacccccttg gctcgcaggc tttcgcccag tttctcaacc tggcggcgcg
    19441 attcacagaa caccagccgc ttctcgccgc ggtgcaaggc ggcgacaacc gtggccgcgt
    19501 tctccatgga gcccacgtag tcgagctgga tatcgccggg tggcggcagc accggggctt
    19561 cgtcgcgcag atgcggggcg acgacgcgtg cctggcgccg gccgcctccc gagccttgaa
    19621 gccaggtgag tagctgctcc gggttgccta ctgtcgccga gagccccact cgctgcaccg
    19681 gcctcccgac gacacgctcc agtcgttcga gtaccgccag cagatgccag ccccggtcgt
    19741 ccccggcgaa agcgtgcacc tcgtcgatca cgatcgcctg tagcccggag aagaaggcac
    19801 ggtgatcgac attggtactg accagcatcg cctccaggga ctccggcgtg gtgagcagaa
    19861 catccgggcg ctcgcgcagg atcttcttgc ggcgcggctg tgttacgtct ccgtgccaaa
    19921 gggccgcggt ccgccccagc caggccgtgc acgtctccag gcgtggcaga agattgttca
    19981 gcagcgcttt cagaggacag acgtacagga cggacgtgcc ggtccagttc tccgtcgcca
    20041 ttttcgacag cagggggaag gacgcggcct cggtcttccc gcccgcggtc ggggcgagga
    20101 gcacggcgtc cgagctgtcg aggagcggtt cgatcgcctc ttcctggagc ggccgcagac
    20161 ctgaccagcc cagggtgttg acgatatggt gcacgagtcc ggggtggagc cggtccagtg
    20221 gttcgggggc acccgtcatg gcagctccag ctcgatctca tcggcgctgt ccgctgccgc
    20281 gttgcgctcg atctcgttca gctcggcggc gttcaccgtc agcgcgtagt gccgccgcgg
    20341 atcgaagtcc tcgaactcgt cgacccggtc cagtacgtcc gcgacgagct tgcgcaggaa
    20401 cagccggggc gcgatgccgg cgcggccgcc gagcctgccc gtcatggccg tggccagctc
    20461 cgccacgtac gcgtcgtcga ccaactccgc gatggattcc ggacgtcggg ccgcaatcgc
    20521 gtacaagtcc cgtacagatc ggccgagttc gccgagccgt tggagatcga atccggtcag
    20581 acgcagctgt acggccctcg gtgagtcgaa gcgtggttcg gtggagaagt cggtggccag
    20641 gcgttgggcg agcgggagca gccgctgcac gccctgctgc ccgtcgtaga aggcgggggt
    20701 gccggtgatc accaggaaga gcccggggaa gcggcccgcg tcgatctcgt cgagaagctg
    20761 gcgcagcgcg ttcagcccct tctcccgaac gtctccgcgt acccgctgca cggtctcgat
    20821 ctcgtcgagg atcaccagga gaccaggatg gccgcagtct ttgagcacgg tgagcaggcc
    20881 ctggaggaag ccgagtgccg cgaagtggtc gaggtcgccg cgcacgcctg cggcgcgccg
    20941 cgcgtgggcg gcgaccgact tctggccgcc gagccaggca atgagggctt cagcggtcga
    21001 gttgtccccg gccagcgtgg ccttgcgata gccccgcagg gcggcggaga aggcgggcgt
    21061 ggtctgggcg acggcgcgca acctttcctc catcagtttt tcgaacg
//
