LOCUS       NZ_CP086322            25140 bp    DNA     linear   CON 26-NOV-2024
DEFINITION  Streptomyces halobius strain 3_2 chromosome, complete genome.
ACCESSION   NZ_CP086322
VERSION     NZ_CP086322.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces halobius
  ORGANISM  Streptomyces halobius
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9239126)
  AUTHORS   Wen,Y., Zhang,W. and Liu,X.G.
  TITLE     Streptomyces nigrumlapis sp.nov.,an antimicrobial producing
            actinobacterium isolated from Black Gobi rocks
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9239126)
  AUTHORS   Zhang,W., Liu,X.G. and Wen,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2021) Northwest Institute of Eco-Environment and
            Resources, CAS, Chinese Academy of Sciences, Donggang West Road 320,
            Lanzhou, Gansu 730000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: GS De Novo Assembler v. FEB-2021
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 241.26X
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023277745.1-RS_2024_11_26
            Annotation Date                   :: 11/26/2024 03:43:17
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,438
            CDSs (total)                      :: 8,346
            Genes (coding)                    :: 7,837
            CDSs (with protein)               :: 7,837
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 509
            CDSs (without protein)            :: 509
            Pseudo Genes (ambiguous residues) :: 0 of 509
            Pseudo Genes (frameshifted)       :: 193 of 509
            Pseudo Genes (incomplete)         :: 418 of 509
            Pseudo Genes (internal stop)      :: 17 of 509
            Pseudo Genes (multiple problems)  :: 113 of 509
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:33:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6796444
            Orig. end                         :: 6821584
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP086322.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25140
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="30"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25140
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25140
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15140](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15140
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            <271..597
                     /locus_tag="K9S39_RS30845"
                     /old_locus_tag="K9S39_30985"
                     /pseudo=""
     CDS             <271..597
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1026: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611325.1"
                     /locus_tag="K9S39_RS30845"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_30985"
                     /product="integrase core domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="HHSDAGSQYTSFTLAEHLDAAGIAASIGSVGDAYDNALMESTIGL
                     FKTEVIKPRRPWKTLSQVELATAEWVDWYNHSRLHGELGHIPPAEYEASHYQATTKPQV
                     TTTI"
     gene            complement(901..1434)
                     /locus_tag="K9S39_RS30850"
                     /old_locus_tag="K9S39_30990"
     CDS             complement(901..1434)
                     /EC_number="2.3.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019061668.1"
                     /locus_tag="K9S39_RS30850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_30990"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_248866613.1"
                     /transl_table=11
                     /translation="MEHPVTTATVELRHFVHDDLPQIRQTLLDVHADAYANDMTEFDER
                     FPWFVDHWGGNAGFACVIGYDGGEPVGFAYGAPATPGREWWREHVNDPPADDSTFSLSE
                     LMVRPKWRKTGTAERLHAALLEDRPEALAVLLVDPNHPKVQTLYEAWGYRKVGNRQPFP
                     DSPNFAVMLHGLPA"
     gene            complement(1419..2705)
                     /locus_tag="K9S39_RS30855"
                     /old_locus_tag="K9S39_30995"
     CDS             complement(1419..2705)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017238179.1"
                     /locus_tag="K9S39_RS30855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_30995"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_248866614.1"
                     /transl_table=11
                     /translation="MAETRNEHLTAWMKDAGMSAAELADAVNEAIRDLTGRPGVTSERT
                     VFRWKSGENRWPQARQRRALEAITGRTVADLGFVPRGKGTTNPVPPTAPPEDPVHRRRF
                     VGAATSTAAAVAVPRITRPPRVGTSDVIRLRDSVENLVALDAERGGHTALERAALAGAD
                     EALGLQRRSTTQRVRQRLFAVSSDFVATAAWSLIDAGQLDAAGKHLDRALTLAGMAQDP
                     DMTMQVWNLRAMLARQRKDYGEAIAAAQAAQATTVARRSPLHASLVCARTAIGLAHAGD
                     HRAALRSLGRAEDALEKADLADPRAPWIAFYGPAELYSLTAIVRDVVGHPTEAEAAAYR
                     ALSALPETYRRNRAHTTARLALAQLHQGDAEQACATSADIFTIMDGDPLPGRMRQLLGD
                     FQRDLFTLAPSAHVAHEWTDRYRNEWSIP"
     misc_feature    complement(1803..1805)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(2511..2513)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3294..3680
                     /locus_tag="K9S39_RS30860"
                     /old_locus_tag="K9S39_31000"
     CDS             3294..3680
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS30860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_31000"
                     /product="hypothetical protein"
                     /protein_id="WP_248866615.1"
                     /transl_table=11
                     /translation="MSAASWAVPPSSTPAALYICARRPGTMSTQPEDKALAEGQAHAER
                     HGWPILHTITDPYDEANPQQRPGWLRVRTLAAANRIGVVITRWPASIAPESLHELRHEE
                     IGKLAADGCTVDYSWSSPISTERA"
     gene            3746..3922
                     /locus_tag="K9S39_RS30865"
                     /old_locus_tag="K9S39_31005"
     CDS             3746..3922
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS30865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_31005"
                     /product="hypothetical protein"
                     /protein_id="WP_248866616.1"
                     /transl_table=11
                     /translation="MTVLGLIGAAPPALVAGPRLADAVAIAVERADAEPGGGPFPHGGR
                     PPYTPSTAVEEAS"
     gene            3919..5103
                     /locus_tag="K9S39_RS30870"
                     /old_locus_tag="K9S39_31010"
     CDS             3919..5103
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS30870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_31010"
                     /product="phosphotransferase"
                     /protein_id="WP_248866617.1"
                     /sec_met_domain="APH (E-value: 2.1e-06, bitscore: 26.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRTPVPTSADLFALSTDRMRRAAHDLWPDGTLSFVDHVPSVTGY
                     VHRVRIDGRDLYAKDSILGLSLVSVLRGLAGDWDAVCAAQLAYATSPASLLAREAAQLR
                     ALNAAGIRVGRCAGYAGGVLFTEPVTGPTLLDLIAKEPYRTRDLLGRAVAGLVPLQHPL
                     VIAQVDAAPIQERSIDGTFRRKFNGISGRHYISALGADRLGEHTRRGAVVVLGVVVDRL
                     LRLSLTPAPGPRDIVYGDLKPEHVLFPDGADEEPVFIDPALTRSPICADVGKLVSRTVL
                     AVIAAPPVDGPAAVVDGIAAFTHDQSRELRGTARGLWWRRLMVTWLMDTVNILSTYLTA
                     PAALPLPEHARAVLDQTEALCTLLDRISAALVAGTAADAAWQLGVQAIVEAADR"
     gene            5100..6008
                     /locus_tag="K9S39_RS30875"
                     /old_locus_tag="K9S39_31015"
     CDS             5100..6008
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007490576.1"
                     /locus_tag="K9S39_RS30875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_31015"
                     /product="lactate/malate family dehydrogenase"
                     /protein_id="WP_248866618.1"
                     /transl_table=11
                     /translation="MTGQTIGIIGAGAIGQTVAALLTHEPWCTQVLVTTRTTERARGLV
                     TDLEDMRQVAASPARVQAATAADLFGSDALVICPRATFTNTANRDVRMAGLAANAPLIA
                     GLARTLTGYAGVAVMVTNPVDVLARLFARISGAATYGVGSATDTARYRLTLAGHYRVPV
                     ETVDGYVIGEHGDHAVICASSTTVAGETAPVPLDLVRTELTARPRRINQGIGRTRCGPA
                     AAVPSALRHLTGYRDGTDVLSVNREGVWIGIRLRIRSGQPTVHPLVLDERETAQFLAAR
                     TKLNAAYQQIQHHEQGEALCR"
     misc_feature    5193..5195
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5999..7138
                     /locus_tag="K9S39_RS30880"
                     /old_locus_tag="K9S39_31020"
     CDS             5999..7138
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019061659.1"
                     /locus_tag="K9S39_RS30880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_31020"
                     /product="hypothetical protein"
                     /protein_id="WP_248866619.1"
                     /transl_table=11
                     /translation="MPLTATRIQADTATVTVASQTAAVTDWSRRYFGPWWNAAAIDAPG
                     PGGIAEGGGLVLADVDPARVDDIIALTREHGRQQTTYANARTVVTCVGEVTYAVQPEER
                     LGYQADGRRLVIVGDQSEPVAVAAARLARELVRGQLLADGWTVLHASAATQNEDTVLTL
                     GGKGAGKTTTALLLARAGWGMLANDRVFARPTPDGLVKVLPWPSAAAIGLGLLDAIGLY
                     DQVRERVLAGGQLHPTQHPKVTQALIDGSREPLWREDGKELKPQFFPDQLSTWLGLSLA
                     TSTTAAGLLFPTMNPEAIPALVEDDRALTDADLFTAKTEDRYPDIFNLTPTAAAGAQAL
                     TEHLARLPRRSVLLSHDTDANTALLVKTAEEITADLEAQ"
     gene            7393..7575
                     /locus_tag="K9S39_RS30885"
                     /old_locus_tag="K9S39_31025"
     CDS             7393..7575
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018893685.1"
                     /locus_tag="K9S39_RS30885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_31025"
                     /product="hypothetical protein"
                     /protein_id="WP_406708044.1"
                     /transl_table=11
                     /translation="MQHRTWVVGECWRCDRIGVPVLWLGPVQTDLGTGPFQACEPCILR
                     LEAKVYAYAEQRDTA"
     misc_feature    7693..7709
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.17"
                     /tool="antismash"
     gene            7693..7920
                     /locus_tag="K9S39_RS30890"
                     /old_locus_tag="K9S39_31030"
     CDS             7693..7920
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS30890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_31030"
                     /product="hypothetical protein"
                     /protein_id="WP_248866621.1"
                     /transl_table=11
                     /translation="MEFNYLYETGDAPGRPARHTSVSISAFGVRMQADGRTRWQAWKVI
                     RREHPVLAWAAPLYVGLLLGLAVAVALAVT"
     gene            7923..8426
                     /locus_tag="K9S39_RS30895"
                     /old_locus_tag="K9S39_31035"
     CDS             7923..8426
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008746446.1"
                     /locus_tag="K9S39_RS30895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_31035"
                     /product="DUF6302 family protein"
                     /protein_id="WP_248866622.1"
                     /transl_table=11
                     /translation="MALPARPFVDLLPPAKAEDEEVEYYRERLEDPALIEAGAAVLIDR
                     YALLAVPAAGQRRGGCLPMPDVVTALAVRAVLAGRPGFPDVRLRWSPYLDACHVVEWGE
                     RPPVHEDDAAHGRFYGYSAEAIARFEAGHVRPQGGGFSTARLSASAQLMAGSASKVEKE
                     EPSD"
     gene            8437..9666
                     /gene="fxlM"
                     /locus_tag="K9S39_RS30900"
                     /old_locus_tag="K9S39_31040"
     CDS             8437..9666
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009329291.1"
                     /locus_tag="K9S39_RS30900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_31040"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_248866623.1"
                     /sec_met_domain="PCMT (E-value: 3e-40, bitscore: 137.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTDQPQNPTVEQQLRDEMVRQLVDLGAARSPHVLTAFRKIPRHL
                     AAPEEDMAKTYRAEQATITKRDANGVDISSVSAARVQAMQIEQADIRPGMRVLEIGSGG
                     VNAAYVAEIVGAGGLVVTLDIDSEVTGRAEKFLAETGYDRQVRVVTADGEYGLAEFAPY
                     DRIIVTVQAADIPPAWIDQLVEGGRLVVPLRMRGMTRTVAFVRDEARLVSDGIELCGFV
                     PMQGAGENRVHLAMLHDAEGEEVALRLDSHPEPDVQALRAALHEPSIKVWSGVTIGGME
                     SKDHLDLWLTTALDNLPLMAAKPAARQRGIVAGVSPMGIPTLVDGVSFAYRTSRRTDDP
                     DRWELGAVGHGPEGQKTAERLVKEIQVWDREHRGHQAHIEVYSAGTPDDQLPAGRLIDR
                     PHTRVTISWP"
     gene            9744..9926
                     /locus_tag="K9S39_RS30905"
                     /old_locus_tag="K9S39_31045"
     CDS             9744..9926
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="K9S39_RS30905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_31045"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_248866624.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 9.3e-14, bitscore:
                     50.0, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSRTTLKTGTEFTADGESSDFDLKIETVASAPVVGALLNDTGDG
                     CGQTCESACSNSTCG"
     gene            10001..13036
                     /locus_tag="K9S39_RS30910"
                     /old_locus_tag="K9S39_31050"
     CDS             10001..13036
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009319705.1"
                     /locus_tag="K9S39_RS30910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_31050"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_248866625.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.3e-182,
                     bitscore: 606.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.5e-17,
                     bitscore: 62.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.3e-30, bitscore:
                     105.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYHAADASMIRASVFPLTATLPSCPSPVDDAADDADNCRQWIAKV
                     WADDARAGAIELAAPVLASGIRKVIDGTARRSRIRRTALSLTRYLLRMQYRATPFGLFA
                     GPAPARVGRAAHVRWGTQRKAFARADATWLHDIITALEQDPDVLRHLPVVADPTCTVRG
                     ARIAVPHQPGAKGPTETTLRRTRAAEMVLALAQSPTTVSAIVAKLHAEYPDTPTQTIEA
                     MVCDLIAHRVLLTSLYAPMTCDDALGHLVAQLDTLALAATPVAPTVGKLRHVYRLLSRH
                     DRAHPVEQRVLRAQATAAMGGLTGTADRSLAVNLRPDCDIVLPEAVTQEAQRALEVIAR
                     ISPYPNGTPAWRDYRVRFLERYSMGTVVPVRDLTDPDTGLGFPAGYRGTILKRPILATT
                     PRDEHLLALAQDSAVSDQREIVLTEDDIEALSNGTPTQVPAHIQFSFSVLAQSTRALDE
                     GRFLLSTVGLSLAAGITTGRFLTMLERADLDRVAAIHASLPTLTSGAVRGQVSGPPLKV
                     PINNVSRTPLVASELLAVGEHNPDVTRDLDDLGVIADATRLYLVSLSTGRLIEPSVMNA
                     VELSNSTHPLIRFLCEVHRSHTTVLVPFAWGAAARLPFLPEVRVGRTILSAARWRLRAG
                     DLGEGDDWMRRFTNWRIRYGLPRTVYLGGSDQRLRLDVDVPAHQQLLRAELRRHNTAVL
                     HEAPEESAFGWIDRAHEVTMSFTSDQQPAPAPASRTATAADRNSGRFPGTSEWAYVKLY
                     GSAARAPEVLTAHLPRLLGDWGAVPPAAWFIRYADPEPHVRLRLRLPCPEAFGTAVQTV
                     TAWAAELRDEGLIQRVQWDTDQPETGRYGTGAALEAAEAYFVADSTAALAQMSLALPTD
                     LQPAITSASYVDVATGFLGSRSAGHEWLIRHLLRSDGEMVPRNIQSLALRLSEGNGRAV
                     LADLDGGDAVAKAWQLRRTALDHYRQSLDADGISPARVLPSLLHMHHNRVAGIDRDAES
                     ACRRIARAAALSCTIRPEGAQR"
     aSDomain        10457..10717
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_K9S39_RS30910_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="5.20E-20"
                     /identifier="RREFam001.1"
                     /label="K9S39_RS30910"
                     /locus_tag="K9S39_RS30910"
                     /protein_end="239"
                     /protein_start="152"
                     /score="62.9"
                     /tool="antismash"
                     /translation="VVADPTCTVRGARIAVPHQPGAKGPTETTLRRTRAAEMVLALAQS
                     PTTVSAIVAKLHAEYPDTPTQTIEAMVCDLIAHRVLLTSLYA"
     misc_feature    10943..10945
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13033..14175
                     /locus_tag="K9S39_RS30915"
                     /old_locus_tag="K9S39_31055"
     CDS             13033..14175
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447324.1"
                     /locus_tag="K9S39_RS30915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_31055"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_248866626.1"
                     /sec_met_domain="LANC_like (E-value: 4.5e-44, bitscore:
                     149.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTALHTTDTSLPSRQSLAHGPLGAALLHVERARRRTGDWQDVHR
                     ALSEIGPLIDGEDSNLYLGAPAMAFVLHLAADGTDRYAGALHTLDNIVATHTRRRLTAA
                     HARIDAGRRTAFAEYDVFRGLTGIGALLLRRQPQGPEMKGVLEYLVRLTKLVTDPAGEK
                     RPGWWVGHAPASDTAATPGGHANAGIAHGITGPLALLALAMRAGVTVDGHEEAIRRICR
                     WLDQIRQSDHRGTRWPRWSSNRGPALALPATPSWCYGTPSLARAQQLAAIVLRDDERKR
                     MAERALLHCLSDPHQLDQIADRGLCHGFGGLLRTVQRVAEDADVPALFTNRLGRITDRF
                     LTAEAPEKTGFLVGKTGAALALLDAETQPQGQWDVCLLLT"
     gene            14199..15140
                     /locus_tag="K9S39_RS30920"
                     /old_locus_tag="K9S39_31060"
     CDS             14199..15140
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447325.1"
                     /locus_tag="K9S39_RS30920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_31060"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_248866627.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.1e-29, bitscore:
                     102.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQVEDAVLAVLSGTPIEDAARSASTSPERLADAIERYRTAGRAA
                     LETRPSGWHQVNIRFADYPTAERAFRAYLLPALRDEPIGAWWFVRKYPHWRLRVYPAPG
                     ATAEEAVAHLTEALDDSVSWGVAKDWRPSPYEPEVVAFGGTDGMALAHELFHTDSVGVL
                     EYLRLATDGHDGMFDAKATSLLAMTLLMRAAGLEFGEQGDVWGQVEERRPLADDVSPNQ
                     VSGMVNTLRRLLLIDASPLLADGPLTPVKNWIQTLERNGQALADAADDGRLNLGLRGIL
                     ARHVFFHWNRMGFTIRQQSIWSRAAREAVLGR"
     gene            complement(15333..16349)
                     /locus_tag="K9S39_RS30925"
                     /old_locus_tag="K9S39_31065"
     CDS             complement(15333..16349)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013775.5"
                     /locus_tag="K9S39_RS30925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_31065"
                     /product="phosphotransferase"
                     /protein_id="WP_248866628.1"
                     /sec_met_domain="APH (E-value: 3.2e-24, bitscore: 85.1,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METADRTDEEVCTEALSAFGLPAPEEVRLIPEGLMNRNWSVRCAA
                     GRYALKEVVDVGPDQARRQHTATRALARAGLLVPAPVTTTDGDTLAAVRGRLYALTPWA
                     AGEMVPARSWRPDRAAAVGALLGELHSELAVAMPEAPATVPVIITAPKKAADRFAHYGR
                     QAAAGESGFDATVERALVERTELLERWADQRPQDGERGPAGWTHGDFHDLNLLWEQGSV
                     SAVLDWDRLAVRPYADEVVRTATLPVMFGSGDEHGLDLELVAAFVGGYRKASELPAAVL
                     AEAAERQRWERICDVWQLKMHYDKGDESCDHLFTAASTLIGWWCRNRQQVADALTAF"
     misc_feature    complement(16580..16590)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(16671..17588)
                     /locus_tag="K9S39_RS30930"
                     /old_locus_tag="K9S39_31070"
     CDS             complement(16671..17588)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS30930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_31070"
                     /product="hypothetical protein"
                     /protein_id="WP_248866629.1"
                     /transl_table=11
                     /translation="MTETRKRGPYARQPHPQEAQIRALLEEGLTNSEVRRRLYVGEKAV
                     ATIRKAAGIPPAPRSAWRRRPHPDERAIRVLLDEGHTDAEIGRRVNADVSTIARIRREG
                     GFGPATIRTRPPRKHPKDAEIRALLGQMSSEAIARKLRVDRVAVRRIRRQAGIMYVPPT
                     FTTAEEKWEARVRPVDGGHLEWTGERGSPSGTPVMRFREKSYSPAAIAFRQRTGRDPVG
                     QVRAECEFKHCIAPAHVDDEPGRIRTRKQLRYLTGGTERRPYCRHGHDQAEHGRYEPDG
                     TAYCEVCKREQKRARCGQAAGGCG"
     gene            complement(18030..19049)
                     /locus_tag="K9S39_RS30935"
                     /old_locus_tag="K9S39_31075"
     CDS             complement(18030..19049)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS30935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_31075"
                     /product="hypothetical protein"
                     /protein_id="WP_248866630.1"
                     /transl_table=11
                     /translation="MSDDEQVPRPGSVPHTFGNALAWRWTRDMPPSLKGGFLTMLYALR
                     TMANASGELRFSGDRKPIRIQDLAKAAGCREKDGRRYIDAAIRAGVVGLEGERRRGRSA
                     LYFLVITPWPDWKAADDHLKATARPRKDSADEKSTGGSSGHSGLNSKAEENGPQRPELP
                     ESAKEGERAAAARMGSGHSGPNGSGRCGPNNPGSTHEVSQERVDVVPQPPVRAGARDEE
                     DQSPQPTDDGELSRRCTGCGIPLVRFSRTLCHGCKIRPEGTPETTQRPVQGAFLTPVPS
                     RTEPLPIVPMHVPVIQEDPLAPLRICGCGREYRHRKPGGRCPDCHYAQQEEAREVSGA"
     gene            complement(19150..19272)
                     /locus_tag="K9S39_RS42190"
     CDS             complement(19150..19272)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS42190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_283113116.1"
                     /transl_table=11
                     /translation="MRLLCTPCYSAATLTEDAGHAVDWTQARAYSLGGLLGEAP"
     gene            complement(19359..19829)
                     /locus_tag="K9S39_RS30940"
                     /old_locus_tag="K9S39_31080"
     CDS             complement(19359..19829)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018560706.1"
                     /locus_tag="K9S39_RS30940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_31080"
                     /product="hypothetical protein"
                     /protein_id="WP_248866631.1"
                     /transl_table=11
                     /translation="MTSAPEPRRAVRFFHGGVPGLRPGDLITPHLPNIVDGCAVCAAKA
                     AGQQPHVPGLGTVDPITARPDRVYITSDREYARFYASKFPRGDLYTVEPVGELEASTED
                     RFPSWTVPAARVRSVYDRYVLLAPRQRRSLLRCWEAADLTAARGATEAEWSR"
     gene            complement(19967..20188)
                     /locus_tag="K9S39_RS30945"
                     /old_locus_tag="K9S39_31085"
     CDS             complement(19967..20188)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039648.4"
                     /locus_tag="K9S39_RS30945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_31085"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_248866632.1"
                     /transl_table=11
                     /translation="MSITAPFGPRTYRPRLTGEARRAKARELARDYKGGSTIRGLALSA
                     GLSYGTVRTLLREEGVELRPRGGHAPMH"
     gene            complement(20185..20661)
                     /locus_tag="K9S39_RS30950"
                     /old_locus_tag="K9S39_31090"
     CDS             complement(20185..20661)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS30950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_31090"
                     /product="hypothetical protein"
                     /protein_id="WP_248866633.1"
                     /transl_table=11
                     /translation="MPVRRRRGGHRGSAGGAVIGPAALAPLIEDVLRHLLDGDLGRAAV
                     VLDDITCRGDAADVFGLCCAVADTGRAVLPVLYPHGYGPGLVVDVPADDAHRLFAARFL
                     TAYDHGDVPMASALYAVAHTAGDRARTESVCALLALVSSFYRRAALSSQEGPRT"
     gene            complement(20607..20939)
                     /locus_tag="K9S39_RS30955"
                     /old_locus_tag="K9S39_31095"
     CDS             complement(20607..20939)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS30955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_31095"
                     /product="hypothetical protein"
                     /protein_id="WP_248866634.1"
                     /transl_table=11
                     /translation="MAISPREIEIRFAPPKTDGDRIAIKARICEAARELALLIHELVPG
                     SREESQAIKACEITVQWAHAGIDRRYVARGERKALAPVLIDPEDAEAACLSAVAEADIA
                     ARPAAL"
     gene            complement(20939..21139)
                     /locus_tag="K9S39_RS30960"
                     /old_locus_tag="K9S39_31100"
     CDS             complement(20939..21139)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010353389.1"
                     /locus_tag="K9S39_RS30960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_31100"
                     /product="hypothetical protein"
                     /protein_id="WP_248866635.1"
                     /transl_table=11
                     /translation="MKIPPSGLLNWTSSVHWSKHQLPCRYCGETTNLRDSSRKAAHKTC
                     AENALTQQAAEAVDAYQKGTL"
     gene            complement(21150..21488)
                     /locus_tag="K9S39_RS30965"
                     /old_locus_tag="K9S39_31105"
     CDS             complement(21150..21488)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011039394.1"
                     /locus_tag="K9S39_RS30965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_31105"
                     /product="WhiB family transcriptional regulator"
                     /protein_id="WP_248866636.1"
                     /transl_table=11
                     /translation="MPRPSRYAPDNLPRPEHWARHAACRGAEEPDVFFPDGDVGLVLLL
                     TEEAKAYCRRCPVRSNCLTTALNRREPLGIWGGLDTDERRALVRLARERAEAAEREEEQ
                     ADARASAA"
     gene            complement(22013..22582)
                     /locus_tag="K9S39_RS30970"
                     /old_locus_tag="K9S39_31110"
     CDS             complement(22013..22582)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006129697.1"
                     /locus_tag="K9S39_RS30970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_31110"
                     /product="Holliday junction endonuclease"
                     /protein_id="WP_248866637.1"
                     /transl_table=11
                     /translation="MTTETFGPKCVRTANGPCVVAFDLSLAGTGIAYRDGSTATVKTQA
                     KDGDRRLLQIAEAARLAVGGEHLGLGPAPDLVVLEDIPQNSFAAKAVSMVHGVVRAVLI
                     EVGVPYALVTAATLKAYATGKGSGDKVPMAMAAYKRAGREFPDDNQCDAWWLWCAGLDQ
                     LGAPPVDLPKVQRDRLAKVTWPEVAR"
     gene            complement(22579..22935)
                     /locus_tag="K9S39_RS30975"
                     /old_locus_tag="K9S39_31115"
     CDS             complement(22579..22935)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS30975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_31115"
                     /product="hypothetical protein"
                     /protein_id="WP_248866638.1"
                     /transl_table=11
                     /translation="MNAPFVMGSVLACGAGLVSAACLWPSRGWHPATGPALAPAADSLP
                     AGLVAVTVPTAVDENPETELTLDADLTTLFAAGEIDATDFDLCPREQRIRPHAIRADGS
                     RRCWECGHETAGDQ"
     gene            complement(22932..23273)
                     /locus_tag="K9S39_RS30980"
                     /old_locus_tag="K9S39_31120"
     CDS             complement(22932..23273)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS30980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_31120"
                     /product="hypothetical protein"
                     /protein_id="WP_248866639.1"
                     /transl_table=11
                     /translation="MSRRSRRAAERQKAADLAAARVELTRLRAELDGAREELAVGQHVD
                     TVAGQSVDTAGLQRENSELRRRLELSERARASLDIQIRQLQRSHDFMCREAVDRAGTLA
                     PVPKAGEPQ"
     gene            complement(23273..23998)
                     /locus_tag="K9S39_RS30985"
                     /old_locus_tag="K9S39_31125"
     CDS             complement(23273..23998)
                     /GO_function="GO:0004527 - exonuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008749143.1"
                     /locus_tag="K9S39_RS30985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_31125"
                     /product="exonuclease domain-containing protein"
                     /protein_id="WP_248866640.1"
                     /transl_table=11
                     /translation="MTWHRRSLVGFDLETTGVDPESDRIVTAAVVRYGGGRPNEMRTWI
                     ADPGVDIPAAAMAVHGYTTEAARAAGRPAGAVVAEIMSALVELVDEGLPLVVMNAAFDL
                     TMLEAEAARYGVKSLFAASVPRVLDPRVLDKHVDRYRRGGRRLEDLCGHYVVPLGAAHD
                     CGADAVAACGVVWKIANRHRWLAQTPLDELHEQQVCWAAEQQAGLRDYFARTPGKEALA
                     SGVRTEWPLIPAQREDGTP"
     gene            complement(23995..24999)
                     /locus_tag="K9S39_RS30990"
                     /old_locus_tag="K9S39_31130"
     CDS             complement(23995..24999)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006259 - DNA metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019548521.1"
                     /locus_tag="K9S39_RS30990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_31130"
                     /product="recombinase RecT"
                     /protein_id="WP_248866641.1"
                     /transl_table=11
                     /translation="MTSTLKDRVRAATEEARHPAKLPTARPAETVDGSTAEELHAAERQ
                     DGGETTDAVLSWLERYGEHFTKALPSHVDQGAFFAAVRAVLPGLVRCTPASLLQALLTC
                     ARFGLVPDGRHAVIRREGKLAVFVPMYQGYVELMYRSGRVGSVHVGMIHAGDEWNYEPT
                     APPPLDFTHKPALELTREQRGKPILAYAFCWMTGGARSQVVILTRQDAEEIRDEYSQAY
                     QRAKAEGREDTFWHTHFDDMWKKSALRRLHKVVPMSAELVQLGKADDAGDAGQTQVLHT
                     PDEDARLLADATAAHKAAEGSQESRQVATLPRKRMQPKRASRKSRRGGKGRRR"
ORIGIN
        1 ccaagcctcg gtctacacgt cggctgcacg gatcgccgtt gagctgacag gagccatgga
       61 aaggttccgc cgccggcggc cagcacgcgt ccgcaagtag agagaagcgg gcgtctaccc
      121 tcctcatcgg tgccccgatt cgtcacgccg gtgctgccgg gcgacaaggt gcaccgcccg
      181 gttcccgtac gggccaccgc ggccccgcgg ccgcatccca gcaccacacg aactgatggc
      241 ctggctcgac ggtcatgccg aagtcgtaca caccactccg acgcgggctc gcagtacaca
      301 tcgttcacgc tcgccgagca cctggacgcg gccggcatcg cagcctcgat cggctcagtc
      361 ggggacgcgt atgacaacgc gctcatggag tccacgatcg gcctgttcaa gaccgaggtg
      421 atcaagcccc ggcggccgtg gaagacgctg tcgcaggtcg agctggccac cgccgagtgg
      481 gtcgactggt acaaccacag ccgcctccac ggtgagctcg gccacatccc gcccgccgaa
      541 tacgaagcca gccactacca agcaaccacg aaaccccagg tcacaaccac catctgagct
      601 ctctaccgaa cccggggcgg ttcagacatc gacgcagcct catctcaaat gatcgagtgg
      661 cggggcggcg gaccggatgt atgggcctcc gacactgcct gaagcctggg ggcttggggg
      721 accagtgaag ctcacctggt cccctgtgcg agcatccccg agcaccagcc agccgcgggc
      781 ccaggaccca gccgacgacg gccgtacgcg gccgctcgac tagcgccctc gtccagagtc
      841 accgccccga ggcgtctcgc cggtgtgtcc ccagcacggg tgctgcagtg gtgctgctgg
      901 ttaggctggc aggccgtgga gcatgaccgc gaagttcggg gagtccggga acggctgacg
      961 gttcccgact ttccggtacc cccatgcctc gtatagcgtc tgcaccttcg gatggttggg
     1021 gtcgaccagg agcacagcca gggcttcggg cctgtcctcc aagagtgcgg cgtgtagccg
     1081 ctcagctgtg ccggttttgc gccacttcgg ccgtaccatc agctcagaca aggagaatgt
     1141 cgagtcatcg gccggcggat cattcacgtg ctcgcgccac cactcacggc ccggcgtggc
     1201 cggggccccg tacgcgaatc cgaccggttc gcctccgtcg tagccgatca cgcacgcgaa
     1261 cccggcattg ccgccccagt ggtcgacaaa ccaggggaac cgctcatcga attcggtcat
     1321 gtcgttcgcg taggcgtcgg cgtgaacgtc gaggagggtt tgcctgatct gcggtaggtc
     1381 atcgtgcacg aagtggcgga gttcgacggt tgccgtggtc acgggatgct ccattcgttc
     1441 cggtagcggt cggtccactc gtgcgcgaca tgcgcggacg gggccagggt gaacaggtcg
     1501 cgttggaagt cgccgaggag ctgacgcatg cggccgggga gcgggtcccc gtccatgatc
     1561 gtgaagatgt ccgcgctggt ggcgcatgcc tgttcagcat cgccttgatg cagctgggcg
     1621 agcgcaaggc gcgcggtggt gtgcgcgcgg ttgcgccggt acgtctcggg gagggcggac
     1681 aacgcccggt acgcggcggc ctcagcctcc gtcggatggc cgacgacgtc gcgcacgatc
     1741 gcggtcagcg agtacagctc tgcaggaccg tagaaggcga tccagggcgc ccgcggatcc
     1801 gctaaatcag ccttttcaag ggcgtcttcg gcgcggccaa gtgaacgcag ggctgcgcga
     1861 tgatccccgg cgtgcgcgag cccaatagcg gtccgcgcac agacgagtga ggcatgcagc
     1921 ggggagcggc gggctacggt cgttgcctgc gcggcctggg cagcggcaat ggcctcgccg
     1981 tagtccttcc gctgccgggc gagcatggcg cggaggttcc acacttgcat ggtcatgtcg
     2041 gggtcctggg ccatgcctgc gagggtcagc gcacggtcaa ggtgtttgcc ggcggcgtcg
     2101 agctgtccgg cgtcgatcag agaccatgca gcggttgcga cgaagtcgga ggagacggcg
     2161 aacaggcgtt ggcgtacgcg ttgtgtggtg gaccggcgtt ggagtcctag ggcctcgtcg
     2221 gctccggcga gggcggcgcg ttcgagggcg gtgtgtccgc cgcgctcggc gtcaagtgcg
     2281 acgaggttct cgacgctgtc acggagtcgg atcacgtcgg aggttccaac gcgtggcggg
     2341 cgggttatgc ggggtacggc gacggcggcg gcggtgctgg tggccgcgcc gacgaaccgg
     2401 cggcggtgca cggggtcctc cggtggtgca gttgggggta cggggttggt ggtgcctttc
     2461 ccccgaggca cgaagcctag gtctgcgacg gttcgaccag tgatggcctc taaagcgcgg
     2521 cgttggcgcg cttggggcca ccggttctct ccggacttcc atcggaacac tgtgcgttcc
     2581 gacgtgacgc cagggcggcc ggtgaggtcg cggatggctt cgttgaccgc gtcggccagc
     2641 tcagcggccg acatgccagc gtccttcatc caggcggtga ggtgttcgtt tctggtctcc
     2701 gccatgagga cacgtgaccc atcgcatcga aggttgagcg gtttcagcga aggctgggca
     2761 cagaatcgcg aggccggacc gggtgaggcc ctcgtgccgc acgctgtgcc cgttgtgcga
     2821 gccttgtcgg ccctgcctcg gccagcccac tcaaccttca cggaacatca cggtaggtgg
     2881 ataggctcgc cacggatagt aaagagcggg tcaattcgtc agcttccacg cgagccaccc
     2941 gcgcaatttc gtcatgcaca acgagcggtg acggtcggtt agctggtgtg tacggccccg
     3001 tcgcgcccgg gtcccccgag ggcacggcgg ggcgccgaac ccgaccgcga gcgcgaggcg
     3061 atcgatatga cgacgcgcgg cacgaccccc cttccaccga ccggcggact cgtggacgcc
     3121 ccagtgctcc actgcgaggc gttgacggac cggcaacgcc agggctcctc gtgttgctgg
     3181 tgcagcggca cccccgaccg ccgattccct gtcccagcac ttcgtacggt cggcgtccgc
     3241 ctgtacgcct gcgtcctgtg cgctggcatg tacggcgttt ctgaggtgtc ccggtgagcg
     3301 ccgcatcgtg ggcagtacca ccgtccagca cgccggccgc gctctacatc tgtgcccgac
     3361 gccccgggac catgtcgacc cagccggagg acaaagcact cgcggagggc caggcgcacg
     3421 ccgagcggca cggctggccg atcctgcaca ccatcaccga cccctacgac gaggcgaacc
     3481 cccagcagcg ccccggatgg ctccgggtac gcacactggc cgccgccaat cggatcggcg
     3541 tcgtcatcac ccgctggcct gcttccatcg ctcccgaatc gctccacgaa ctgcggcacg
     3601 aggagatcgg gaagttggcc gcggacggct gcacggtgga ctactcctgg tcgtcgccga
     3661 tctcgacgga gagggcgtga gcggcgcgca tgcggcgccg gcgccgcgac cgtcggagca
     3721 cggacgagac gggttagcag gcgcgttgac ggtgcttggt ctcatcggcg cggccccgcc
     3781 ggccctggtc gccggtccgc gcctcgctga cgccgtcgcc atcgccgtcg agcgcgcgga
     3841 cgccgagccc ggtggcgggc ccttcccgca cggcggtcgg ccaccgtaca caccctctac
     3901 cgccgtcgag gaggcatctt gacccgcaca cccgtaccca catccgcgga cctgttcgcg
     3961 ctcagcaccg accggatgcg ccgcgccgcg cacgacctgt ggcccgacgg gacgctgtcc
     4021 ttcgttgatc acgtgccctc ggtcaccggc tacgtccacc gcgtccgcat cgacggccgg
     4081 gacctgtacg cgaaggattc catccttggc ctgtccctcg tttcggtcct gcggggcctg
     4141 gccggcgact gggacgccgt ctgtgccgca cagctcgcct acgccacctc tcccgcctcg
     4201 ctgttggcgc gggaagccgc acagctccgt gccctgaacg cggccgggat ccgcgtgggc
     4261 cgctgcgccg gatatgcggg cggggtgctg ttcaccgagc ccgtgaccgg tccgaccctg
     4321 ctggacctga ttgccaagga gccgtaccgc acgcgggatc tactcgggcg ggccgtggcc
     4381 ggactcgtac cgctccagca cccgctcgtg atcgcccagg ttgatgccgc gccgatccaa
     4441 gagcgcagta tcgatgggac gttccgccgg aagttcaacg gcatttccgg ccgccactac
     4501 atcagcgccc tcggtgctga ccggctcggc gaacataccc gccgcggcgc ggtcgtcgtg
     4561 ctcggcgttg tggtggaccg gctgctgcgc ctcagtctca cccctgcccc gggtccgcgc
     4621 gacattgtgt acggggacct gaagcccgaa cacgtgctgt tcccggacgg tgcggacgaa
     4681 gagccggtgt tcatcgaccc cgccctaacc cgcagtccga tctgcgcgga tgtggggaaa
     4741 ctcgtctcgc gtacagtcct tgccgtgatc gcggcgccgc cggtcgacgg cccggccgcg
     4801 gtggtggacg gcatcgccgc cttcacccac gaccagtccc gtgaactgcg cggcacggcc
     4861 cggggactgt ggtggcgccg gctgatggtg acgtggctga tggacacggt caacatcctg
     4921 tccacctacc tcaccgcccc ggcggccctg ccgctgcccg agcacgcccg cgcggtactg
     4981 gaccagacag aggcactgtg caccctgctg gaccgcatca gcgccgctct tgtggccggg
     5041 acagccgcgg atgccgcctg gcaactcggc gtgcaggcaa tcgtcgaggc agcggaccgg
     5101 tgaccggcca gacgatcggc atcatcggtg ccggcgcgat cggacagacc gtcgccgctc
     5161 tcctgaccca tgagccgtgg tgcacgcagg tgttagtcac cacgcgcacc accgagcgcg
     5221 cccgcggcct ggtcaccgat ctggaggaca tgcgacaggt cgccgcatcc cccgcccgag
     5281 tacaggcagc cacagcggca gacctgttcg gcagtgacgc gctggtgatc tgcccgcgcg
     5341 ccaccttcac caacaccgcg aaccgggatg tgcgcatggc cggcctcgcc gcaaatgccc
     5401 cgctgatcgc cggcctcgcc cgcaccctca ccggatacgc cggtgttgcg gtcatggtca
     5461 ccaaccctgt ggatgtcctc gcccgcctct tcgcccgtat cagcggcgcc gccacctacg
     5521 gggtcggctc cgcaaccgac accgcccgct accgcctcac cctcgccggc cactaccgcg
     5581 tgccggtcga aaccgtggac ggctacgtga tcggcgagca cggcgaccac gccgtcatct
     5641 gcgcctcatc caccaccgtg gccggcgaga cggctccggt gccgctcgac ctggtacgga
     5701 ccgaactcac cgcccggcca cgccgcatca accaagggat cggccgcacc cggtgcggcc
     5761 cggccgccgc cgtcccgtcc gcactgcggc acctgacggg ctaccgggac gggaccgacg
     5821 tcctgtcagt caaccgcgaa ggcgtatgga tcggaattcg gttgcgcatc cgttccggtc
     5881 aaccaaccgt gcaccccttg gtcctggacg aacgtgagac cgcccagttc ctcgccgccc
     5941 ggaccaagct caacgccgcc tatcagcaga tccaacacca cgagcaagga gaggccctgt
     6001 gccgctgacc gcaactcgca tccaggccga caccgccacg gtcaccgtcg ccagccagac
     6061 cgcggccgtc accgactggt cgcgtcgcta cttcggtccc tggtggaacg ccgcggccat
     6121 cgacgcgccg ggccccggcg gcatcgccga gggcggcggc ctggtcctcg ccgatgtcga
     6181 cccggcccgc gtggacgaca tcattgccct cacccgtgag cacggccgcc agcagaccac
     6241 ctacgcgaac gcccgtaccg tggtcacctg cgtgggcgaa gtcacgtacg cggtgcagcc
     6301 cgaggagcgg ctcggctacc aggccgacgg ccgccgcttg gtcatcgtcg gcgaccagtc
     6361 ggagccggtt gccgtcgccg cggcccggct ggcgcgcgaa ctcgtccgcg gtcagctcct
     6421 ggccgacggc tggaccgtgc tccacgcctc cgccgccacg cagaatgagg atacggtcct
     6481 gaccctgggc ggcaagggcg ccggcaagac caccactgcc ctcctcctgg cccgcgccgg
     6541 atggggcatg ctcgccaatg atcgcgtctt cgcccgtccc accccagatg gcctcgtgaa
     6601 ggtgctgccg tggccgtcgg ccgccgccat cggccttggg ctcctggacg cgatcggtct
     6661 gtacgaccag gtgcgggaaa gggttctcgc tggcgggcag ctccacccca cccagcaccc
     6721 caaggtgacc caggccctca tcgatggcag ccgcgagccg ctgtggcgcg aggacggcaa
     6781 ggagctgaag ccgcagttct tccccgacca gctctccact tggctcggcc tgagcctggc
     6841 caccagcacg accgcggccg ggctcctctt cccaaccatg aatcctgagg cgatccccgc
     6901 actcgtcgaa gacgaccgcg ccctgaccga cgcggacctg ttcaccgcca agaccgaaga
     6961 ccgctacccc gacatcttca acctgacccc caccgccgcg gccggcgccc aagcgctgac
     7021 cgagcacctt gcccgcctcc cccgccggtc ggtgctcctc agccacgaca ccgacgcgaa
     7081 cacggcgctt ctggtcaaaa ccgccgagga gatcacggcc gacctggagg cacagtgacg
     7141 aaagggagcg ttgtgcgacg acaacgacca ggcgccacat gagcgaccgt aacgcccaac
     7201 tcctctacgt ggccttgctg gtcgcggtga tggtcatgct cgcgttcgcc atcacgcact
     7261 gctgaagccc ccgccccgtc cggaacgcct ccccgtggtg gccggccggg gtgggaccgg
     7321 gctccggtcg ccgcccatcc caccaggtgg cggccggagc caccaccaat gacaaagagg
     7381 ggaggccgcc ccgtgcagca tcggacatgg gtcgtcggcg agtgctggag gtgcgaccgc
     7441 atcggcgtgc cggtgctctg gctcggcccg gtacagaccg acctcgggac cggccccttc
     7501 caagcctgcg agccgtgcat tctccgcctg gaggcgaagg tctacgccta tgccgagcag
     7561 cgcgacacgg cctgaaagtc cccgcccccg gccgtgcagt gcgacgacgt atggccgggg
     7621 cgcgggtcac cacacaccga cctggcccgg ggcgccgatg cggcgctggc tttgttctga
     7681 ccgaggagca ccatggaatt caactacctc tacgagaccg gcgacgcacc cggccggccc
     7741 gcccggcaca cgtcggtgag catcagcgcg ttcggcgtgc ggatgcaggc tgacggccgt
     7801 accaggtggc aggcatggaa ggtcatccgc cgcgagcatc cggtgctggc atgggcggcg
     7861 ccgctgtacg tcggcctgct cctgggcctg gcggtcgcgg ttgccctagc tgtgacgtga
     7921 cggtggcgct gcccgcgcgg cccttcgtgg acctcctgcc gcccgccaag gctgaggacg
     7981 aagaagtgga gtactaccgg gaacggttgg aggaccccgc gctcatcgaa gcgggtgcgg
     8041 cggtcctcat cgaccgatac gcgctgctcg ccgtcccggc ggccggccag cgccgcggcg
     8101 gctgcctgcc catgccggac gtcgtgaccg cgctcgccgt gcgcgcggtg ctcgctggcc
     8161 gaccgggctt ccctgatgtc cggctgcgct ggtccccgta cctcgacgcc tgccacgtcg
     8221 tcgagtgggg cgagcgtccc ccggttcatg aggacgacgc ggcacacggg cggttctacg
     8281 gctacagcgc cgaagccatc gcacgattcg aggccggcca tgtaagacct caaggcggag
     8341 gtttctcaac cgcccgcctg tcggcatcgg cgcaactcat ggccggatcg gcgagcaagg
     8401 tcgagaagga ggagcccagt gactaacgtc cctgaagtga ctacagatca gcctcaaaac
     8461 cccaccgtcg aacagcagtt gcgcgatgag atggtcaggc agctcgtcga cctaggcgcc
     8521 gcccggagcc cgcacgtcct gaccgcgttt cgcaagatcc cccggcacct ggcggcaccc
     8581 gaggaggaca tggccaagac gtaccgggcg gagcaagcca cgatcacgaa aagggacgcc
     8641 aatggcgtgg acatcagctc ggtgtccgct gcccgcgtgc aggccatgca gatcgagcag
     8701 gcggacatcc ggcctgggat gcgcgtgctg gagatcggct ctggtggcgt caacgccgcg
     8761 tacgtcgctg agatcgtcgg tgcgggtggc ctggtcgtca ccctggacat cgatagcgag
     8821 gtcaccgggc gggccgagaa gttcctggct gagaccggct acgaccggca ggtgcgggtc
     8881 gtcaccgccg acggtgagta cggccttgct gagttcgctc cgtacgaccg catcatcgtc
     8941 acggtgcagg ccgcagacat cccaccggcg tggatcgacc aactcgtgga aggggggagg
     9001 ctcgtcgtcc cgctgcggat gcgcggcatg acgcgcacgg tggccttcgt ccgcgatgag
     9061 gcacgcctgg tcagcgacgg gatcgaattg tgcggcttcg tgccgatgca gggcgccggc
     9121 gagaacaggg tgcatctggc catgctccac gacgccgagg gtgaagaggt cgccctacgc
     9181 ttggacagcc atcccgagcc cgatgtccag gccctgcgcg ccgcccttca cgagcccagc
     9241 atcaaggtgt ggtccggggt gacgatcggc ggcatggagt cgaaggacca cctggacctg
     9301 tggctgacga ccgccctgga caacctgcct ctcatggcgg cgaaacccgc ggcccggcag
     9361 cgcggcatcg tggccggggt ctccccgatg ggcatcccga ccctcgtaga cggggtcagc
     9421 ttcgcctacc gcacatcgcg ccggaccgac gaccctgaca ggtgggagct gggcgcggtc
     9481 ggccacgggc cggagggtca gaagaccgcc gagcgcctgg tcaaggagat ccaggtgtgg
     9541 gaccgcgagc accgcggcca ccaggcgcac atcgaggtct actcggcggg cacgccggac
     9601 gatcagcttc ccgcgggccg gctcatcgac cggccgcaca cgcgggtcac gatctcctgg
     9661 ccgtgacgcc ccggcgttgc gctcaggagg caccaccagc acgaccgagc acatccacaa
     9721 acccctctat ccgaggagac gagatgtcat cgcgtacgac gctgaagaca ggtacggagt
     9781 tcactgctga cggtgagtcg tcggacttcg acctgaagat cgagaccgtg gcctccgcgc
     9841 ctgtggtcgg ggccctgctg aacgacaccg gcgacggctg tggccagacc tgcgagtccg
     9901 cctgctccaa cagcacctgc gggtgacccc acagcccggg gcgggccggg cagccaaccc
     9961 acccgccccg ggcgctgcat ccccctacgg aggcacagcc atgtaccacg cagctgacgc
    10021 gagcatgatc agggcgtccg tgtttccact gacggccacg ctgccctcct gcccctctcc
    10081 cgtcgatgac gctgccgacg acgccgacaa ctgccgccag tggatcgcca aggtctgggc
    10141 cgacgatgcc cgtgctggtg ccatcgaact cgccgcgccc gtcctcgcct ccgggatccg
    10201 caaggtgatc gacggaactg cccgccgttc ccgcatccgc cgtacagcgc tttccctgac
    10261 ccgctacctg ctgcggatgc agtaccgcgc caccccgttc gggctgttcg ccggccccgc
    10321 acctgcgcgc gtcggccgcg cggcacacgt ccgctggggc acacagcgca aggcgttcgc
    10381 cagggccgac gcgacatggc tgcacgacat catcacagcc ttggaacagg acccggacgt
    10441 gctgcggcac ctgcctgtag tggccgatcc cacctgcacc gtgcggggtg cccggatcgc
    10501 cgtcccacac cagccgggag ccaaggggcc caccgagacg acgcttcggc gcactcgcgc
    10561 cgcggagatg gtcctcgccc tggcccagtc acccaccacc gtcagcgcca tcgtggccaa
    10621 actccacgcc gaataccccg acactcctac ccagacgatc gaggccatgg tgtgcgacct
    10681 gatcgcccac cgtgtcctac tgaccagcct ttatgccccg atgacctgtg acgacgcgct
    10741 tggccacctg gtcgcgcagc tcgacacgtt ggccctggcg gccaccccgg tcgcgccgac
    10801 ggtcgggaag ctgcgtcacg tctaccggct tctctcccga cacgaccgcg cccacccggt
    10861 cgaacaacgg gtgctccgcg cgcaggccac cgccgcaatg ggcggcctca ccggcaccgc
    10921 cgaccgcagc cttgcggtga acttacgtcc agactgcgac atcgtcctgc ccgaggcagt
    10981 cacgcaggag gcccagcggg ccctggaggt catcgcccgc atctcgccgt acccaaacgg
    11041 caccccagcc tggcgggact accgcgtccg gttcctggag cgctacagca tgggcaccgt
    11101 cgtgccggta cgcgacctca ccgaccccga cacgggcctc ggcttccctg ccggctaccg
    11161 cggcacgatc ctgaagcgtc ccatcctggc cacaacgccc cgcgacgaac acctcctcgc
    11221 cctcgcccag gactccgctg tatccgatca gcgcgagatt gtcctcactg aggacgacat
    11281 cgaggccctg tccaatggca cacccacaca ggtccccgca cacatacagt tcagcttcag
    11341 cgtgcttgcg cagtccacgc gcgccctgga cgagggccgt ttcctactgt ccaccgtggg
    11401 gctgtccctc gcggctggca tcaccaccgg ccgcttcctg acaatgctgg aacgggcgga
    11461 cctcgaccga gtggccgcca tccacgcctc cctgcccacg ctgacttcgg gcgccgtccg
    11521 cggacaggtc tccggccctc cgctgaaagt gccgatcaac aacgtcagcc ggaccccgct
    11581 cgtcgcctcc gagctactgg ccgtcggcga gcacaacccg gacgtcaccc gagacctcga
    11641 tgacctgggc gtcatcgccg acgccacgcg cctctatctg gtgtccctct ccaccggtcg
    11701 gctgatcgaa ccgtcggtca tgaacgccgt ggagctgagc aacagcaccc acccgctgat
    11761 ccgcttcctg tgcgaagtgc accgctccca caccaccgtc ctcgtgccgt tcgcctgggg
    11821 agctgcggcc cggcttccgt tcctcccaga ggtccgcgtc ggccgcacca tcctgtccgc
    11881 agctcgctgg cgactgcgtg ccggcgacct gggggagggg gacgattgga tgcgtcgctt
    11941 caccaactgg cgcatccgct acggcctgcc acgcaccgtc tacctcggcg gcagcgacca
    12001 acgcctaaga ctcgacgtcg atgttcccgc ccatcagcaa ctattgcgcg ccgaactccg
    12061 ccgccacaac accgccgtgc tacacgaggc gccggaagag agcgccttcg gctggatcga
    12121 ccgcgcccac gaggtgacca tgtccttcac ctccgaccag cagcccgccc cggcgcccgc
    12181 gtcccgcaca gccaccgcag cggaccggaa ctctggccgc ttccccggga catcggagtg
    12241 ggcgtacgtg aaactctacg gcagcgccgc gcgggcaccg gaggtgctga ccgcacacct
    12301 tccgcgcctc ctgggtgact ggggtgccgt cccgccggca gcgtggttca tccgatacgc
    12361 ggaccccgag ccgcatgtgc ggcttcggct gcggcttccc tgtccagagg cgttcggcac
    12421 ggccgtgcaa acggtgactg cgtgggcggc agagctgcgc gatgagggct tgatccagcg
    12481 tgttcagtgg gacaccgacc agccggagac cggccgctac ggaaccggcg ccgcgctgga
    12541 agctgcggaa gcgtacttcg tggccgattc gacggccgcc ctcgcacaga tgtccctggc
    12601 cctgcccact gacctccagc cggccatcac ctcggcgtcg tacgtcgacg tcgcaaccgg
    12661 cttcctcggc tcccgctcgg ccgggcacga gtggctgatc cgccacctgc tccgcagcga
    12721 cggcgagatg gtcccccgca acatccagtc ccttgcccta cgcctgtcgg agggcaacgg
    12781 ccgggccgtg ctcgccgacc tcgacggagg tgacgccgta gccaaggcgt ggcagctgcg
    12841 acgcacagcg ctcgaccact accgccagtc gctcgacgct gacggaatct ccccggccag
    12901 ggtgcttccg tccctgctgc acatgcacca caaccgggtc gcaggcatcg accgcgacgc
    12961 cgaatccgcc tgccgccgca ttgcccgcgc cgcggccctg tcctgcacta tccgccccga
    13021 aggagcacag cggtgaccac cgccctgcac accaccgaca cgtccctacc ctcccggcag
    13081 tccctcgcgc acggccctct cggggcagcc ctgctgcacg tagagcgggc acgccgccgc
    13141 accggagact ggcaggacgt gcaccgtgcc ctgtccgaga tcgggccctt gatcgacggc
    13201 gaggactcca acctctacct cggtgcacct gcgatggcct tcgtcttgca cctggctgcc
    13261 gacggcaccg accggtacgc aggggcgctg cacaccctcg acaacatcgt ggccacccac
    13321 acccggcgcc gtctgaccgc cgcgcacgcc cgcatcgacg cgggccgccg caccgcgttc
    13381 gccgaatacg acgtgttccg cggcttgacc ggcatcgggg cactgctgct gcgccgccag
    13441 ccacaaggac cggaaatgaa gggcgtgttg gagtacctgg tccgcctaac aaaactggtg
    13501 actgaccctg cgggtgagaa acggcccggc tggtgggtgg ggcatgcgcc ggccagcgac
    13561 acggcggcta cgccgggcgg gcacgcgaac gccggtatcg cgcacggcat caccggcccg
    13621 ctcgccctcc tggccctggc catgcgcgcc ggggtcaccg tggacggcca tgaggaggcc
    13681 atacgccgta tctgccggtg gcttgaccag atccgccaga gcgaccatcg cggaacccga
    13741 tggccccggt ggagcagcaa ccgcggcccc gccctcgcac tgccagccac gccgtcctgg
    13801 tgctacggaa cgcccagcct ggcccgcgca cagcagctcg ccgcgattgt cctgcgcgac
    13861 gacgagcgca agcggatggc cgaacgggca ctgctgcact gcctgagcga tccgcaccaa
    13921 ctcgaccaga ttgcagaccg gggcctctgc cacgggtttg gcggcctcct gcgtaccgtg
    13981 cagcgtgtcg ccgaagacgc ggatgtgcca gctctgttca ccaaccgact cggccggatc
    14041 acggaccggt tcctcaccgc cgaggcaccc gagaagaccg ggttcctcgt ggggaagacc
    14101 ggtgcggccc tagcccttct cgacgccgaa acccaacccc aagggcaatg ggacgtctgc
    14161 cttctgctga cgtgagagag acacgcatgc tgcacaacat gagccaggtc gaagacgctg
    14221 ttctggccgt cctcagcggg acaccgatcg aagacgcggc ccggtccgcg agcacctccc
    14281 ccgaacggct ggccgatgcc atcgagcgct accgaaccgc cggccgggcc gcgctcgaaa
    14341 cccgcccctc cggatggcac caggtgaaca tccgcttcgc cgactacccc accgcagagc
    14401 gcgccttccg cgcctacctg ttgcccgccc tccgcgacga gcccatcggc gcatggtggt
    14461 tcgtgcggaa gtacccgcac tggagactgc gcgtataccc ggcaccgggc gccaccgcag
    14521 aggaggcggt cgcgcacctc accgaagcgc tcgacgactc tgtctcctgg ggcgtggcca
    14581 aggactggcg gccctcccct tacgaaccgg aagtcgtcgc cttcgggggc acggacggga
    14641 tggcccttgc gcacgaactg ttccacacgg acagcgtcgg cgtcctggaa tacctacgcc
    14701 tcgccaccga tggccacgac ggaatgttcg acgccaaggc cacctcactg ctcgccatga
    14761 cactactgat gcgggctgcc ggcctggagt tcggcgaaca gggcgacgtg tggggacagg
    14821 tcgaagaacg tcgcccccta gcggacgacg tgtccccgaa ccaggtcagc ggcatggtga
    14881 acaccctgcg tcgcctgctc ctgatcgacg cttcacccct gctcgccgac ggccccctca
    14941 cacccgtgaa gaactggatc caaacgctgg agcggaacgg ccaagccctc gcggacgccg
    15001 cagacgacgg gcgactcaac ctcggtctgc gcggcatcct cgcgcgccac gtgttcttcc
    15061 actggaaccg catggggttt acgatccggc agcaatctat ctggtcacgc gccgcccggg
    15121 aggccgttct cggacgttga ccgagggacg cctgacaatc gtatccaagc accaggccgc
    15181 actccccgcc ccaccggagc ggcggcgccg gcgtgtggcg ccggggcatg gccaggggcg
    15241 cggcagcggc cgggaacggg gcctggcagc ggccgggaac ggggcctggc aaatcgtgca
    15301 ccaggcgacg gccgccgtcg gcgagaagcc gatcagaacg ctgtgagcgc gtcagcgact
    15361 tgctgacggt tgcggcacca ccagccgatc agcgtggagg cggcggtgaa caggtggtcg
    15421 caggattcat cgcccttgtc gtagtgcatc ttgagctgcc acacgtcaca gatgcgctcc
    15481 cagcgctgcc gctcggcggc ctccgccagc actgcggctg gcagttcgct ggccttccgg
    15541 tatccgccga cgaacgccgc caccagctcc aggtccaggc cgtgctcatc ccctgagccg
    15601 aacatcaccg gcagcgtcgc cgtgcgcacg acttcgtccg cgtatgggcg gaccgcgagc
    15661 cggtcccaat ccagcaccgc actgaccgat ccctgctccc aaaggaggtt cagatcatgg
    15721 aagtccccat gagtccatcc ggccgggccc cgctcaccgt cctggggccg ctggtcggcc
    15781 caccgctcca gcagctccgt gcgctcgacg agcgcccgct ccaccgtcgc atcgaatccg
    15841 ctctctcccg ccgcagcttg gcggccatag tgggcgaagc gatcggctgc cttcttcggc
    15901 gcggtgatga tcacgggcac ggtggccggg gcctcgggca tcgcgactgc cagctcggag
    15961 tgcagctcgc cgagcagcgc cccgacagcg gcggcgcggt cgggacgcca cgagcgggca
    16021 ggaaccatct cccccgccgc ccacggagtg agcgcgtaca gacgtccgcg cacggcggcg
    16081 agggtgtctc cgtccgtagt ggtcaccgga gccggcacca gcagcccggc cctggccaga
    16141 gcccgggtcg cggtgtgctg gcggcgtgcc tggtcggggc cgacgtcgac gacctctttg
    16201 agggcgtacc ggccggcggc gcagcgcacg gaccagttgc ggttcatcag cccctcaggg
    16261 atcagtcgca cttcctccgg ggcgggcaaa ccgaacgccg acagcgcctc ggtgcagacc
    16321 tcctcatccg tacggtctgc cgtctccatg cccgcgctcc tcatccgtcc cgctcgcccc
    16381 cggcctgctc cagggtgccc gagcctacgg agcaccagcg tgatcacggg gaggctcccg
    16441 tgaagcgctc ctcgaacgtg cgacccggcg gcaaccggcc agtgcgggtg gtggtggagg
    16501 ggctgtgcct ggccgggaaa tccacgatcg tcgccgcccc tcgccccact tctgggcgcg
    16561 cacgcggtgc ccgagtacgg tgacctggca ccgctgccac cgtggccacc cgccgacacc
    16621 ggcgccgcgc gagccggcct ggaccacctc gccagcgtcg aacgggcacg tcagccgcag
    16681 ccgcccgccg cctgaccaca gcgggcgcgc ttctgctccc tcttacacac ctcgcagtac
    16741 gcggtgccgt ccggctcgta ccggccatgc tcggcctgat cgtggccgtg ccggcagtac
    16801 gggcgccgtt ccgtgccccc ggtgaggtag cgcagttgct tgcgggtacg gatgcggccg
    16861 ggctcgtcgt cgacgtgggc cggtgcaatg cagtgcttga actcgcactc cgcccgcacc
    16921 tggccgactg ggtcgcgacc ggtgcgctgc cggaaggcga tcgccgcggg actgtaggac
    16981 ttctcccgga accgcatgac cggtgttcca ctcggcgatc cgcgctcgcc agtccactcc
    17041 aggtgtccgc cgtcgacggg ccggacgcgg gcctcccact tctcctcagc ggtggtgaag
    17101 gtcggcggga cgtacatgat gccggcttgg cggcggatgc ggcgcaccgc gacgcggtcc
    17161 acgcggagct tccgggcgat ggcctcgctg ctcatctgtc ccaggagcgc gcggatttcg
    17221 gcgtccttcg ggtgcttgcg gggtggccgg gtcctgatgg tcgccgggcc gaacccgccc
    17281 tcccggcgga tgcgggcgat ggtgctgacg tcagcattca cccggcggcc aatctccgcg
    17341 tcggtgtgcc cctcgtcgag gagcacgcgg atcgcccgct catccgggtg cggacggcgg
    17401 cgccaggcgc tccgaggcgc tgggggaatg ccggccgcct tgcggatggt ggccacggct
    17461 ttctcgccga cgtacagccg tcggcgaacc tcactgttcg tcaggccctc ttccaggagc
    17521 gcgcggatct gggcctcctg cgggtgcggc tggcgggcgt aggggccgcg cttgcgggtc
    17581 tcggtcactg ggcggtcgtc tccgtggttt caggcccggc ggcggccggg tgcatgtggg
    17641 gcgggtagcg gtgggtgccg cggccggcgg cggcgagggc gcgagtgacc gcgcgggcgc
    17701 cgtagcggcg cgcggcctcc tcctcaccga gctcggcgac ggcgccgtgg acacctcaag
    17761 gtccgccgtg ctggcggccg tctgcgtccg gcgggtgcgg atgcgacaca ggaggcaggc
    17821 gccgccgctg tccggctcga ccgggccgtg cgggtgctcc gggcacgtcg tgcccgtccg
    17881 gcccgcggct gtgaggaggc gccggacgcg gtcgaggccg gcgccgatgg cgtgcaggac
    17941 ttcgggggtg atgtcctgcg gggcggtccg ggctgcgttc tcgccgatgg tgcggagtgc
    18001 ggtgaggagt tccggcagga cggtgcggtt cacgcgccgc tcacctcccg ggcctcctcc
    18061 tgctgggcgt agtggcaatc cgggcaccgg ccgccgggtt tgcggtgccg gtactcccgg
    18121 ccgcacccgc agatgcgcag cggggccaac gggtcctcct ggatcacagg aacatgcatg
    18181 ggaacgatcg ggaggggctc ggtccgggac ggcaccgggg tgaggaacgc gccttgaaca
    18241 ggccgttgtg ttgtctccgg ggtgccctcg gggcggatct tgcatccgtg gcagagcgtg
    18301 cggctgaagc gaaccagcgg gattccgcat ccggtgcacc gccgggacag ctcgccgtcg
    18361 tccgtcggct ggggggattg atcttcttca tctcgcgcgc ctgcgcggac cggtggctga
    18421 ggtactacat caaccctctc ctgggatacc tcgtgggtac tacctgggtt gttcgggcca
    18481 cagcggcccg aaccgttcgg gccactgtgg ccggaaccca ttcgggccgc agcggcccgt
    18541 tctccctcct tggcactctc gggaagttcg ggccgctgtg gcccgttctc ctctgccttc
    18601 gagttcaggc cgctgtggcc cgaacttcca ccggtgctct tctcgtctgc ggagtccttc
    18661 cgaggccggg cggtcgcctt gaggtggtcg tcggcggcct tccagtccgg ccagggggtg
    18721 atgacgagga agtagagagc cgaccggccc cggcggcgct caccttcaag gccgacgact
    18781 cctgcccgga tcgcagcgtc gatgtagcgg cggccgtcct tctcccggca tccggccgcc
    18841 ttggcgaggt cctggatccg gatcggcttc cggtcgccgc tgaaccggag ctccccggag
    18901 gcgttcgcca tcgtgcgcaa ggcatagagc atcgtgagga agccgccctt gagggagggc
    18961 ggcatatcgc gcgtccagcg ccaggcgagc gcgttgccga aggtgtgcgg cacgctgccg
    19021 ggccgtggga cctgctcgtc gtcgctcacg agcaccctct ctcgtcagtc ctggtctggg
    19081 gcggtcctgg tggcgttgcg tcccgtaagt ccgcccccgg ggggtgtcgg ccccgggccg
    19141 cggtcgccgt cacggcgcct cacccagcaa gccgcccaag ctgtacgccc gggcctgcgt
    19201 ccagtcgacg gcatggccgg catcctcggt gagcgtcgcg gcggagtagc acggggtgca
    19261 cagcagcctc acgagcccat cccggcgtga ccggtgacgg cacaagtgcc ggggcagacg
    19321 gcatagcgcg catcggccca ggggcggcag acgccccgtc accggctcca ctccgcctcg
    19381 gtagcccccc gagcagcggt gaggtccgcg gcctcccagc agcgcagcag cgaccggcgc
    19441 tggcgcggcg cgaggagaac gtaccggtcg tacaccgacc gcacccgggc ggctggcacc
    19501 gtccagcttg ggaaccggtc ttccgtggac gcttccaact cgccgacggg ctcgaccgtg
    19561 tagaggtcac cgcgcgggaa cttcgacgcg tagaacctcg cgtactcccg atcgctggtg
    19621 atgtagacgc ggtcaggccg ggcggtgatc gggtcgacgg tgccaagtcc gggaacgtgc
    19681 ggctgctggc cggccgcctt cgcggcgcag accgcacagc cgtcgacgat gttcggcagg
    19741 tgcggggtga tgaggtcccc aggacggagg ccgggcacgc cgccgtggaa gaaccggacg
    19801 gcacggcgtg gctcgggggc tgaggtcatg gaaaggctcc ggcggtgatg cggtgaaggg
    19861 gggcagacaa gcaccgggcg cagtgacacc gggggctcgg ggcggcatac ccccgcaggt
    19921 gtccggacct gtccggacac ccggacgggc ggggtatccg tgctggtcaa tgcatcgggg
    19981 catgtccgcc gcgcgggcgg agctcgacgc cctcctcccg aagcagggtt cggaccgtgc
    20041 catatgagag gccagcggag agggcgaggc cgcgaatcgt cgacccaccc ttgtagtccc
    20101 gggcgagttc gcgggccttc gcgcggcgtg cctccccagt gagccggggc cggtaggtgc
    20161 gcgggccgaa cggggcggta atgctcatgt gcgggggcct tcctgagatg agagggcagc
    20221 gcggcggtag aaggaggaga caagtgcaag gagggcgcac accgactccg tccgggcccg
    20281 gtcgccggcc gtgtgggcaa cggcgtaaag ggcggaggcc atcggcacgt caccgtggtc
    20341 gtaggcggtg aggaaccggg cggcgaacag ccggtgggcg tcgtcggccg ggacgtctac
    20401 gacgaggccc ggcccgtacc cgtgcgggta gaggaccggc agcaccgcac ggccggtgtc
    20461 ggccacggcg cagcacaggc caaagacgtc ggcagcgtca ccgcggcagg tgatgtcatc
    20521 cagcacgacc gcggcccggc cgaggtcacc gtctagcagg tgccggagaa cgtcctctat
    20581 gagcggcgcg agggccgccg ggccgatcac agcgccgccg gccgagccgc gatgtccgcc
    20641 tcggcgacgg cggacaggca tgcggcctcc gcgtcctccg ggtcgatgag gaccggcgcc
    20701 agtgccttgc gctcaccgcg ggcgacgtac cggcggtcaa tgccggcgtg cgcccactgc
    20761 accgtgatct cgcatgcctt gatcgcctga gactcctccc tggagccagg gaccaactca
    20821 tgaatgagca acgccagttc acgggccgcc tcgcagatac gggcctttat ggcgatgcgg
    20881 tccccgtcgg tcttcggcgg ggcgaatctg atctcgatct cacgcgggct gatcgccatc
    20941 acagggttcc tttctggtag gcatcgaccg cctcggcggc ctgttgggtc agggcgtttt
    21001 cggcgcacgt cttgtgtgcc gccttccggc tggagtcgcg gaggttcgtc gtctcgccgc
    21061 agtagcggca cgggagttgg tgcttcgacc agtgcacgga cgacgtccag ttgaggagcc
    21121 cgctcggcgg gatcttcacg cgccgggggc tacgccgcgg acgcgcgggc atcggcctgc
    21181 tcctcctctc gctctgccgc ttcggcgcgc tcgcgagcca ggcgcaccag ggcacgccgc
    21241 tcgtccgtgt cgaggccgcc ccagatcccc aagggctccc tgcgattgag ggcggtggtc
    21301 aggcagttcg agcgcacagg gcagcgccgg cagtaggcct tggcttcctc ggtgaggagg
    21361 aggaccaggc ccacgtcgcc gtccgggaag aagacgtcag gctcctccgc gccgcggcat
    21421 gcggcgtgcc gggcccagtg ctcgggccgc gggagattgt cgggtgcgta tcggctcgga
    21481 cgaggcatca gagtgctcct gctccgtcgt gtccgggggg gtccggacgg ttgtccgtgg
    21541 tcatgtccgg agacgtgtcc gcgcagttca gggccgtctc accggaaggc gccggggggt
    21601 tatccggggt tgtccggacg ccggcccgga cgactttcca gagtggcttc cgtcgtcccc
    21661 ggtggcggcc ggacggccgg agctcccacc acgcgaggaa cgcaagcacg gcgagaacca
    21721 ccggcgccca cacggggaag gtctcgatca cggggaaggc gagagagcca aagacgagga
    21781 atgcctcaag gacgtccatc agccaccccg ccctcttgcc gccagcggac gacggtgcgt
    21841 gccgcgatga gccggtcagc gatgaccgcg actgagaggc cggtcgcggt cctctccagg
    21901 gcggcgtgcc gctgttcctc ctctgtgagc tccggcagtg gcggggcacc gtggatgacc
    21961 cgctcaacgg caaccaggtc gattccgcgg taccacgttg ctcccacagg gatcaccggg
    22021 ctacctccgg ccacgtcacc ttggcgagcc ggtcccgctg aaccttgggg agatcgacgg
    22081 gcggtgcgcc gagctggtcc agcccggcgc accagagcca ccaggcatcg cactggttgt
    22141 catcagggaa ctcccggccc gcgcgcttgt acgcggccat cgccataggg accttgtcgc
    22201 cggatccctt gccggtcgca tacgccttga gcgtcgcggc cgtcacgagg gcgtacggga
    22261 cgccgacctc gatcagcacg gcgcggacga ccccgtgcac catgctgact gccttcgctg
    22321 caaagctgtt ctgcgggatg tcctccagga ccacgaggtc cggcgccggg ccgagcccga
    22381 ggtgttcacc accgaccgcg aggcgggcgg cctcagcgat ctgcaggagg cggcggtctc
    22441 cgtccttcgc ctgcgtcttc accgtggccg tagagccgtc ccggtaggcg atcccggtcc
    22501 cagcaaggga caggtcgaag gcgaccacgc acgggccgtt agcagtccgg acgcacttcg
    22561 ggccgaaagt ctcggtggtc actggtcacc tgccgtttcg tgaccgcatt cccagcagcg
    22621 ccgtgacccg tccgcacgaa tggcgtgcgg acggatgcgc tgctcgcgcg gacagaggtc
    22681 gaagtcggtg gcgtcgatct ccccggccgc aaagagggtg gtgaggtcgg cgtccagggt
    22741 gagctccgtt tccgggttct cgtcgacggc agtcggcacg gtcaccgcga cgagaccggc
    22801 ggggagcgag tcggctgccg gggcgagtgc tggaccggtc gcggggtgcc agccccgcga
    22861 cggccacagg caggccgccg acacgagccc ggcaccgcac gccagcaccg agcccatgac
    22921 gaacggggcg ttcactgcgg ctcacccgcc ttcggaaccg gggcgagcgt cccagcccgg
    22981 tcgacggcct cccgacacat gaagtcgtgg gagcgctgca actgcctgat ctggatatcg
    23041 aggcttgcgc gtgcccgctc ggacagctcc aggcgacgcc gcaactccga gttctcccgc
    23101 tgtagtccgg cggtgtccac gctctggccg gcgacggtgt ccacgtgctg gccgacggcc
    23161 agctcctccc gggcgccgtc gagctcggcg cgcaggcgcg tcaactccac gcgggcggcg
    23221 gcgagatcag cggccttctg gcgttcagca gcgcgacgcg atctacggct catcacgggg
    23281 taccgtcctc tcgctgggcg ggaatcagag gccactcggt gcgcaccccg gaggccagcg
    23341 cctccttgcc aggcgtccga gcgaagtagt cgcgcagccc ggcctgctgc tcagccgccc
    23401 aacacacctg ctgctcgtgc agctcatcga gcggcgtctg cgccagccac cggtgccggt
    23461 tcgcgatctt ccagacgaca ccgcaggcgg cgaccgcgtc cgcgccacag tcgtgtgccg
    23521 cgcccagcgg caccacgtag tggccgcaca ggtcttcaag gcgccggccg cccctccggt
    23581 accggtcgac gtgcttgtcc agcacgcgcg ggtccagcac ccttggcacc gacgcggcga
    23641 acagcgactt caccccgtac cgggcggcct cggcctccag catcgtcagg tcgaacgccg
    23701 cgttcatcac gaccagcggc aggccctcgt cgaccagctc aacaagcgcc gacatgatct
    23761 cggcgaccac ggccccggcc gggcggcccg cagcgcgggc cgcctcggtc gtgtaaccgt
    23821 gcaccgccat cgcagccgcg gggatgtcca ccccgggatc cgcgatccag gtacgcatct
    23881 cgttgggccg gccgccgccg tagcggacga cggcggccgt cacgatccgg tccgactcgg
    23941 gatccacccc agtcgtctcc aggtcgaacc ccaccaggga gcggcgatgc caggtcaccg
    24001 gcggcgcccc ttcccccctc gacgggactt gcgactggcg cgcttgggct gcatccgctt
    24061 cctcggcagc gtggcgacct gccgggactc ctgagagccc tcagccgcct tgtgcgccgc
    24121 ggtggcgtcg gcgaggagcc tcgcgtcctc gtccggtgtg tggaggacct gcgtctgccc
    24181 ggcgtcaccg gcatcgtcgg ccttcccgag ctgcaccagc tcggccgaca tgggcaccac
    24241 cttgtgcagc cgccgcagcg ccgacttctt ccacatgtcg tcgaagtggg tgtgccagaa
    24301 ggtgtcctcc cggccttcgg ccttggcccg ctggtacgcc tggctgtact cgtcgcggat
    24361 ctcctcggcg tcctggcgcg tcaggatgac gacctgggag cgggcgccgc cggtcatcca
    24421 gcagaacgcg tacgcgagga tcggcttccc gcgctgctcg cgggtcagct ccagcgcggg
    24481 cttgtgcgtg aagtcgagcg ggggaggggc ggtgggctcg tagttccact cgtctccggc
    24541 atggatcatc ccgacgtgca cgctgccgac ccgcccggag cggtacatca gctcgacgta
    24601 gccctggtac atcggcacga acaccgcgag cttgccctcg cgtcggatga ccgcgtggcg
    24661 tccgtccggc acgagtccga accgggcgca cgtcagcagc gcctggagca ggctcgcggg
    24721 ggtgcagcgg accaggccgg gcaggaccgc ccgcacggcc gcgaagaacg cgccctgatc
    24781 gacgtgggaa ggcagggcct tcgtgaagtg ctcgccgtac cgctccagcc aggacaggac
    24841 ggcgtcggtg gtctcgccgc cgtcctgccg ctcagcggcg tgcagttcct cggctgtgct
    24901 gccgtcgacg gtctcggcgg ggcgtgccgt cgggagcttc gccgggtgcc gggcctcttc
    24961 ggtggccgcg cggacgcggt ctttcaacgt gctcgtcacg gtcacactcc cttctcgggc
    25021 acgttcagca cacgggcgcg gtaagcggcg tacgtctcgg ggtggtcggc cttgagccgg
    25081 tcggtgtcga tcgcggggac caggtgcgtg tacgcggcgg ccagctccgg ctccgcctca
//
