LOCUS       NZ_CP086322            22280 bp    DNA     linear   CON 26-NOV-2024
DEFINITION  Streptomyces halobius strain 3_2 chromosome, complete genome.
ACCESSION   NZ_CP086322
VERSION     NZ_CP086322.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces halobius
  ORGANISM  Streptomyces halobius
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9239126)
  AUTHORS   Wen,Y., Zhang,W. and Liu,X.G.
  TITLE     Streptomyces nigrumlapis sp.nov.,an antimicrobial producing
            actinobacterium isolated from Black Gobi rocks
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9239126)
  AUTHORS   Zhang,W., Liu,X.G. and Wen,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2021) Northwest Institute of Eco-Environment and
            Resources, CAS, Chinese Academy of Sciences, Donggang West Road 320,
            Lanzhou, Gansu 730000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: GS De Novo Assembler v. FEB-2021
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 241.26X
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023277745.1-RS_2024_11_26
            Annotation Date                   :: 11/26/2024 03:43:17
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,438
            CDSs (total)                      :: 8,346
            Genes (coding)                    :: 7,837
            CDSs (with protein)               :: 7,837
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 509
            CDSs (without protein)            :: 509
            Pseudo Genes (ambiguous residues) :: 0 of 509
            Pseudo Genes (frameshifted)       :: 193 of 509
            Pseudo Genes (incomplete)         :: 418 of 509
            Pseudo Genes (internal stop)      :: 17 of 509
            Pseudo Genes (multiple problems)  :: 113 of 509
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:33:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2772446
            Orig. end                         :: 2794726
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP086322.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22280
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="22"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22280
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22280
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12280](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12280)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            1384..2307
                     /locus_tag="K9S39_RS12775"
                     /old_locus_tag="K9S39_12865"
     CDS             1384..2307
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612064.1"
                     /locus_tag="K9S39_RS12775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_12865"
                     /product="LLM class F420-dependent oxidoreductase"
                     /protein_id="WP_248868713.1"
                     /transl_table=11
                     /translation="MELRIFTEPQQGATYETLLRVARTAEELGYGAFFRSDHYLHMGNV
                     DGLPGPTDAWTTLAGLARETQRIRLGTLMTAGTFRLPGVLAIQVAQVDQMSGGRVDLGL
                     GSGWYAEEHAAYGIPFPKEKFGRLEEQLAIIRGLWDTPVGERFTFDGNFYQLQDSPALP
                     KPAQSHVPLLIGGHGARRTPALAAQYADEFNIPFASLEDTERQFKRVRAAAEERGRKAD
                     DLVYSNALVVCVGKSDAEVERRADAIGREVEELKANGLAGSPAEVVERLGRFAALGSQR
                     VYLQMLDLDDLDHMELIAAEVMPQLS"
     gene            complement(2559..3014)
                     /locus_tag="K9S39_RS12780"
                     /old_locus_tag="K9S39_12870"
     CDS             complement(2559..3014)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577478.1"
                     /locus_tag="K9S39_RS12780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_12870"
                     /product="DUF6099 family protein"
                     /protein_id="WP_248863463.1"
                     /transl_table=11
                     /translation="MDAVRIIAANRRGLAQAGTAHDVVVEAWQAQALSEAIGSHLAIFG
                     PYEVRSRARGLGDAGGRFSGGLLCSGPATGGLRAAQLSEVRDVKAALAGMCQLLQEVCE
                     ALVSVVSTADEEGMYWTCVEAIDMADESRDRVAGILEKLEVRDRDLA"
     gene            complement(3424..3783)
                     /locus_tag="K9S39_RS12785"
                     /old_locus_tag="K9S39_12875"
     CDS             complement(3424..3783)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088816.1"
                     /locus_tag="K9S39_RS12785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_12875"
                     /product="nucleotide pyrophosphohydrolase"
                     /protein_id="WP_248863464.1"
                     /transl_table=11
                     /translation="MSEDLQALQRRLAAFAAARDWQQYHTPKNLAAALSVEAAELVEIF
                     QWLTPEESAKVMSDPERAGRVEDEVADVLAYLLQFCEALGIDALTALAAKIERNESRFP
                     PGPSARPDRPRGSEG"
     gene            complement(3780..5303)
                     /locus_tag="K9S39_RS12790"
                     /old_locus_tag="K9S39_12880"
     CDS             complement(3780..5303)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088815.1"
                     /locus_tag="K9S39_RS12790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_12880"
                     /product="biotin transporter BioY"
                     /protein_id="WP_248863465.1"
                     /transl_table=11
                     /translation="MDTDSVRPAVTELRLSAFKSHRGVTLPLGPLTLLSGESGSGKSSA
                     LQAYEILARLGSGERLARAVEVVAGGATACVPAGARPDGQGRRGFRIGCTVDGPAGPVS
                     LDLAVQAEPELRIVGERLTGGGQTLLTTALTDPSRPAVQAAWHTAGATPVTRAPLPDDR
                     LGTSLLPLRVAGKTAGQRLVLAAAEQVVVALRSAFVCDPRPEVMRAAGRGGDAAQGGGD
                     GHGGSGGGGAVRNGARGGGREGSSGGSRGAGRGGARAGRRGGGESGDWRRDGDEEVVDE
                     GRLRPSCDNLPAVLDRTSRECRRRHEVLVRAVREASTGPVDGLRAVPRQGSAEGAVDAG
                     PGVGQKAGVGSAPAAQGAQGPRVAQLTQPSRGAEAAQAVSGSPMVDASQAGRGSQGMRA
                     VIDRGALGALPIEQLGDGELRFVALALVLLTGPGVLAMDPAGEIPSAQQQLTVLADGMD
                     RCMDQRQARELVSLAVRMTERGHVRLLGTVRDPSVAEGLPDVRVLHLGV"
     misc_feature    complement(5265..5267)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5359..5748)
                     /locus_tag="K9S39_RS12795"
                     /old_locus_tag="K9S39_12885"
     CDS             complement(5359..5748)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088814.1"
                     /locus_tag="K9S39_RS12795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_12885"
                     /product="cell division protein SepF"
                     /protein_id="WP_248863466.1"
                     /transl_table=11
                     /translation="MNDPDATDEQWEGLAEVVPLRSGSEWPSWPDHRALPEEEPAEEMR
                     RFIVIRVQTFADAREVAEYLMAQIPVLLDLSSADTDVAKRILDFSSGVVFGLGSGMHRV
                     DTNVFLLAPIGTEVAEAAGGTVPRS"
     gene            6037..6612
                     /locus_tag="K9S39_RS12800"
                     /old_locus_tag="K9S39_12890"
     CDS             6037..6612
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009714506.1"
                     /locus_tag="K9S39_RS12800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_12890"
                     /product="hypothetical protein"
                     /protein_id="WP_248863467.1"
                     /transl_table=11
                     /translation="MGDSTVWTVAIAALTGGTAVLASWVTSRGSTQAARIQAEIVARSQ
                     RAERLRESRRTAYLDLIEQTHRMGELYWEISASLRLPESADRTAALHELYDREIAEYAR
                     MRRCARVVELEGPAAAAAAALALQKATGPFFSAFKAELDGNSGARNGDTDNQRDNHEEF
                     NAAYNPFWKALEDFVDAARDAHQNGEGA"
     gene            complement(6616..7269)
                     /locus_tag="K9S39_RS12805"
                     /old_locus_tag="K9S39_12895"
     CDS             complement(6616..7269)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003985365.1"
                     /locus_tag="K9S39_RS12805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_12895"
                     /product="hypothetical protein"
                     /protein_id="WP_248863468.1"
                     /transl_table=11
                     /translation="MGQTLALQTVENFLTEEELTQLRKIVATGLGGWRPAFQAQVVEAP
                     EEAQDILHSALERALPVLRRVLPSVRSAAPWGYTELGEGESVPAHIDGIVDPAARPRRS
                     GRIGVVLDDADRGGGFYVETSSDPVLWDGRIAGPEDGFAPDTPLTRHLPAGTHGLQQHD
                     QQPGWLQRAHRTRWMCDAGPGTVVAYGAQVLHGVTPVVDGRLRKFVTDLLDDTL"
     gene            complement(7511..9820)
                     /locus_tag="K9S39_RS12810"
                     /old_locus_tag="K9S39_12900"
     CDS             complement(7511..9820)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981083.1"
                     /locus_tag="K9S39_RS12810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_12900"
                     /product="UvrD-helicase domain-containing protein"
                     /protein_id="WP_406707919.1"
                     /transl_table=11
                     /translation="MTEPSPSRWGAGLQLGATPRQLLHHRATTYGHYSAYEGGEYMAAG
                     GSAARRAQEARLQERLLREQWRAARQRALRWEAASEGERRVAAQLLVLTERGWRLLVDR
                     RWPGTRAANVDMLLIGPGGVFVVDVKNWQAAPETSDGELRAGGESRDEHRRKLLAVTKT
                     AEGAVASLGLSPVAVQPVMAFVGRQVNVELGRIRLLGEYEIGPALLRERTRLSAAQVRA
                     IAEHLERVFPEYEDPSAKRSAPARGAPTPQSARTPQAARNSWPPVAGRTGQSDRAPART
                     VPSRSRPRQPGSEPDGLFDLDGLCQAALDEARQAPIEQWMTFLHPDQVALVRRNWAGPA
                     RISGPAGTGKTVVGLHRAAHLARHTTGRVLYVTFANNLPRVQGTFLKTMAPAVADRIDF
                     RSLHSWAQEFLKGRGVPVQLNKARAETAFSFAWKDVGRDSCLAEIDPSPHYWHEEISYV
                     IKGRGIASFEEYAAVARRRRRTTLRRAHRRAVWALYEAYESHRTERAVHDFNDILSLAL
                     EEATGAGDSPYRAVIVDEVQDLTLVGVRLLYALVGDTPNGLLLVGDGQQAVYPGGFRLS
                     DAGVDIRGDRGQVLRTNYRNSKEIVDAALAIVAEDSFEDIDGLRTPGRRDVDLTYHDGR
                     VHRVVKPTAAEHDQALVAALRELTPQERSDAAVLCSSKRAIDGYQRLLTQAGIRVCLLE
                     HYDGHTVEAVKLGSYRRAKGLEFKRVYLPLHDADVPTGPESAETARERGELARSQLFVA
                     MTRARDVLWLGSVRPR"
     misc_feature    complement(9242..9244)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..12280)
                     /locus_tag="K9S39_RS12815"
                     /old_locus_tag="K9S39_12905"
     CDS             complement(10001..12280)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604221.1"
                     /locus_tag="K9S39_RS12815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_12905"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_248863469.1"
                     /sec_met_domain="T1TS (E-value: 7.1e-82, bitscore: 275.0,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTETTQTTQPFELPNFYVPHPARLNPHLESARKHSKKWARGMGML
                     EGSDIWEERDLDAHDYALLCSYTHPDASEQALSMVTDWYVWVFFFDDHFLEKFKRTQDR
                     EGGKAYLDRLPAFMPMDLATPMPEPTNPVEAGLADLWQRTVPHMSMAWRARFAEATEHL
                     LNESLWELANINIHRVPNPVEYIEMRRKVGGAPWSSGLVEFAAGAEIPAAVADSRPLRV
                     LKDTFCDGVHLRNDLFSYQRETQDEGELSNGVLVLETFLDCTTQEAADAVNDLITSRLQ
                     QFENTVLGELPALFVEKGLDPKSCADVLAYAKGLQDWQSGGHEWHMRSSRYMNGGGAAA
                     GAPLSSSAASASWSPFAVSGLGTSAADLKRALATAAGRRARSHSHVPYTKVGPSKIPDI
                     YMPFTLTLSPHLETSRRNVIAWAHRMGMLRPQPGVPFSGIWDEPAIKRHDLALCAAGLH
                     PDATLEELDLGTQWLAWGTYADDYYPAVFGRTRDLAPAKACNERLSQLMTVDFSAPTTA
                     PVTPLERGLADLWSRTAGPMSPDARRSFRAAVETMISSWLWELENQALNRIPDPVDYIE
                     MRRATFGADLTMSLSRIGHGRTVPPEIYRTGPMRSLENSAVDYACLLNDVFSYQKEIEY
                     EGEVHNSLLVVQNFFDCDYPAALAIVHDLMTSRMREFQHVAANELPIVYDDFNLSGEAR
                     AALDGYVKELENWMAGILNWHRDCRRYREEYLSHGPVSPMWPGGPTGLGTSAARILPSL
                     LSLSAG"
     misc_feature    12246..12261
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.7"
                     /tool="antismash"
     gene            complement(12393..12977)
                     /locus_tag="K9S39_RS12820"
                     /old_locus_tag="K9S39_12910"
     CDS             complement(12393..12977)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS12820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_12910"
                     /product="hypothetical protein"
                     /protein_id="WP_248863470.1"
                     /transl_table=11
                     /translation="MAALHLSLPTGYPRTVARRLAWPAAVTGLAALTLVGLLTAAGHPL
                     DPAATLAELAGRTVPRGGCAVWATVRFGSTAPATGMVVAGVLAKWLLIDRVVCRRGPGQ
                     ALPALLSGALGVPVHRDDAERINGTRNASHTMHHTPAPCITHLHHASHTCITHHAQPIS
                     ETPLMSSNGPDWLECAHEIRKTATLLNADQR"
     misc_feature    13284..13299
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     gene            13556..14536
                     /locus_tag="K9S39_RS12825"
                     /old_locus_tag="K9S39_12915"
     CDS             13556..14536
                     /NRPS_PKS="Domain: Polyketide_cyc2 (23-159). E-value:
                     6e-16. Score: 51.1. Matches aSDomain:
                     nrpspksdomains_K9S39_RS12825_Polyketide_cyc2.1"
                     /NRPS_PKS="Domain: Polyketide_cyc2 (171-321). E-value:
                     1.4e-09. Score: 30.4. Matches aSDomain:
                     nrpspksdomains_K9S39_RS12825_Polyketide_cyc2.2"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1128: cyclase/dehydrase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018106305.1"
                     /locus_tag="K9S39_RS12825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_12915"
                     /product="aromatase/cyclase"
                     /protein_id="WP_283112309.1"
                     /transl_table=11
                     /translation="MHRDRRLCRGDGLALAGLRRYGRRIAAPADQVYALIRDAVDWPQH
                     FIPTLHVERAALGPDSERLWIWATANGDVTHWTSHRTLDPRRRRIVFEQEVCSPPVAAM
                     SGEWTVDDGPDGGCELVLHHTFSAVDDLPENVDWITSATDRNSRTELANIRALAENAQA
                     DAELLFSFADSETVRGPSEQVYAFLQEAGAWPDRLPHVSRLDLREPSEGLQLMTMVTRA
                     GNGSEHTTESVRVCFPHDRIVYKQLTTPPLMATHIGQWLLQETDDGVCVTSHHTIRVNE
                     AAIPAVLGPEATPATARDYLREAVGGNSAATLSLAKRFAEAPHAV"
     aSDomain        13625..14032
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K9S39_RS12825_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="6.00E-16"
                     /label="K9S39_RS12825_Polyketide_cyc2.1"
                     /locus_tag="K9S39_RS12825"
                     /protein_end="159"
                     /protein_start="23"
                     /score="51.1"
                     /tool="antismash"
                     /translation="RIAAPADQVYALIRDAVDWPQHFIPTLHVERAALGPDSERLWIWA
                     TANGDVTHWTSHRTLDPRRRRIVFEQEVCSPPVAAMSGEWTVDDGPDGGCELVLHHTFS
                     AVDDLPENVDWITSATDRNSRTELANIRALAE"
     aSModule        13625..14518
                     /domains="nrpspksdomains_K9S39_RS12825_Polyketide_cyc2.1"
                     /domains="nrpspksdomains_K9S39_RS12825_Polyketide_cyc2.2"
                     /incomplete
                     /locus_tags="K9S39_RS12825"
                     /tool="antismash"
                     /type="unknown"
     aSDomain        14069..14518
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K9S39_RS12825_Polyketide_cyc2.2"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="1.40E-09"
                     /label="K9S39_RS12825_Polyketide_cyc2.2"
                     /locus_tag="K9S39_RS12825"
                     /protein_end="321"
                     /protein_start="171"
                     /score="30.4"
                     /tool="antismash"
                     /translation="ADSETVRGPSEQVYAFLQEAGAWPDRLPHVSRLDLREPSEGLQLM
                     TMVTRAGNGSEHTTESVRVCFPHDRIVYKQLTTPPLMATHIGQWLLQETDDGVCVTSHH
                     TIRVNEAAIPAVLGPEATPATARDYLREAVGGNSAATLSLAKRFAE"
     gene            14526..16253
                     /locus_tag="K9S39_RS12830"
                     /old_locus_tag="K9S39_12920"
     CDS             14526..16253
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669816.1"
                     /locus_tag="K9S39_RS12830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_12920"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_248863471.1"
                     /sec_met_domain="DAO (E-value: 7e-07, bitscore: 28.1,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSEPGGPHPDGDRAPQVLVAGAGPVGLTLAHELARRGVRVRVVD
                     RAAGPATSSRALALHPRTLELCHQMGLADALLERGRRVTHFTLHLRGRELIRFNTNYTR
                     LPTAYPFSLMLDQVHTEEVLRTRLAELGVRIEWGVELRDCVTEGPHVAVRLGHGDRTAE
                     LTVPWLVGADGSRSTVRKRLGLRLVGDATQTWLNADVVLDVDLPPDSNHLVHTGSGSVL
                     LVPFPESGKWRAVDTEYARYDRGGERGDGPEVVRRRLAEALSRGLGRPVAVAEPTWVSV
                     FRVQQRMITAMRAGRCFVAGDAAHVHSPASGQGMNTGMQDAVNLAWKLAQVVRGEADEA
                     LLDTYAAERVPVGGRLLSSTRKATALVALRNAAAPVLMPVGLTALRALGPVKRRVEHRF
                     MAGLSGLALHYADSPLSSAPPSSPQRLGRRGAGVEPGHRVGCTARDAARHPGWWALRQA
                     LADPRWTLLHFSQSAAERTSEEGDLTFLVERFGRAVRVHEVHPGGRSRSNGGAIPDPGG
                     VLRRTLGVPAGGYALIRPDGYLAAKGPRATADTLTAALRAVHLLSDVDAPQLPTSTPA"
     gene            16318..17088
                     /locus_tag="K9S39_RS12835"
                     /old_locus_tag="K9S39_12925"
     CDS             16318..17088
                     /NRPS_PKS="Domain: PKS_KR (15-177). E-value: 4.4e-10.
                     Score: 31.7. Matches aSDomain:
                     nrpspksdomains_K9S39_RS12835_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669815.1"
                     /locus_tag="K9S39_RS12835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_12925"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_248863472.1"
                     /sec_met_domain="adh_short_C2 (E-value: 6e-32, bitscore:
                     110.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRESDDPAAAHGSVALVTGATRGLGLAIASKLTAAGCEVLLNY
                     AHDESAARAAERALAEAGGKVRLLRADIGRPAGVVRMLDEVRRVHGTLDLLVHSAGTYH
                     PAPAAAPHIGRALRDGAVALGPLLYGAGRLSDLMTPGTGRIVAVSSTGAHSVVPGYAGL
                     GMAKAALETLVRYLAVELADRGVAVNAVAAGKLADGASAVLPAEAVAGLVRRTAVGRLT
                     AAVEVADVVGLLCRPEAGGLHGQVLTVDGGASLR"
     aSDomain        16363..16848
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K9S39_RS12835_PKS_KR.1"
                     /evalue="4.40E-10"
                     /label="K9S39_RS12835_PKS_KR.1"
                     /locus_tag="K9S39_RS12835"
                     /protein_end="177"
                     /protein_start="15"
                     /score="31.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VALVTGATRGLGLAIASKLTAAGCEVLLNYAHDESAARAAERALA
                     EAGGKVRLLRADIGRPAGVVRMLDEVRRVHGTLDLLVHSAGTYHPAPAAAPHIGRALRD
                     GAVALGPLLYGAGRLSDLMTPGTGRIVAVSSTGAHSVVPGYAGLGMAKAALETLVRYL"
     CDS_motif       16369..16434
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K9S39_RS12835_0001"
                     /evalue="4.50E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="K9S39_RS12835"
                     /protein_end="39"
                     /protein_start="17"
                     /score="16.1"
                     /tool="antismash"
                     /translation="LVTGATRGLGLAIASKLTAAGC"
     gene            17108..17925
                     /locus_tag="K9S39_RS12840"
                     /old_locus_tag="K9S39_12930"
                     /pseudo=""
     CDS             17108..17925
                     /GO_function="GO:0016812 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds, in cyclic amides
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007492852.1"
                     /locus_tag="K9S39_RS12840"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_12930"
                     /product="cyclase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRIIDLSTTVDASQWEVDPVIHEVLTPAEGGRHMAEGMRRNHGVV
                     FDPAELPDGELLSLDTLKLTTHTGTHVDAPSHYGSRAGYGGTPRHIDQMPLDWFLRPGF
                     RLDLTGEPVGAIGADRVRRALDACGCTPAPMDIVLLYTGADQLAGTPAYFTDFGGLDAE
                     ATHLLLDLGSRSSAPTRSAWTRPSAT"
     gene            complement(18042..19106)
                     /locus_tag="K9S39_RS12845"
                     /old_locus_tag="K9S39_12935"
     CDS             complement(18042..19106)
                     /EC_number="2.3.1.-"
                     /NRPS_PKS="Domain: PKS_AT (36-314). E-value: 1.6e-70.
                     Score: 229.8. Matches aSDomain:
                     nrpspksdomains_K9S39_RS12845_PKS_AT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981033.1"
                     /locus_tag="K9S39_RS12845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_12935"
                     /product="acyltransferase domain-containing protein"
                     /protein_id="WP_248863473.1"
                     /sec_met_domain="PKS_AT (E-value: 2.2e-68, bitscore: 229.8,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQTPLAGPVTAASAADRARCRGAAARHASRPVALLLPGQGSQYP
                     RMTAGLYGTVAAFTEALDEVFDAMGREGARIRADWLAEQSELPMDHVLRAQPLLFAVDY
                     ALGRTVESWGVRPAALLGHSIGELAAATLAGVFSVHDAAHVVLDRVVRLAHSPPGGMIA
                     VAASADQLAPFLDCEVVVAAVNAPLQTVLAGPEGALRAVGERLRVRGVAVRPVPALSPF
                     HSPAIAPYAMGATAVLASVARHSPAVPIHSCATAAPLTAREIADPVYWAAQPVAKVRFW
                     PALQGLLASGEFSLVEAGPGRGLSLLARQHPAVRRGDSGVLPLSPRRVRGPEDEVATLD
                     AARQALRRELEPRA"
     aSDomain        complement(18165..18998)
                     /ASF="(Methyl)Malonyl-CoA specificity inconclusive"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K9S39_RS12845_PKS_AT.1"
                     /evalue="1.60E-70"
                     /label="K9S39_RS12845_PKS_AT.1"
                     /locus_tag="K9S39_RS12845"
                     /protein_end="314"
                     /protein_start="36"
                     /score="229.8"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LPGQGSQYPRMTAGLYGTVAAFTEALDEVFDAMGREGARIRADWL
                     AEQSELPMDHVLRAQPLLFAVDYALGRTVESWGVRPAALLGHSIGELAAATLAGVFSVH
                     DAAHVVLDRVVRLAHSPPGGMIAVAASADQLAPFLDCEVVVAAVNAPLQTVLAGPEGAL
                     RAVGERLRVRGVAVRPVPALSPFHSPAIAPYAMGATAVLASVARHSPAVPIHSCATAAP
                     LTAREIADPVYWAAQPVAKVRFWPALQGLLASGEFSLVEAGPGRGLSLLARQHPAV"
     CDS_motif       complement(18525..18563)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K9S39_RS12845_0004"
                     /evalue="4.00E-04"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="K9S39_RS12845"
                     /protein_end="194"
                     /protein_start="181"
                     /score="13.6"
                     /tool="antismash"
                     /translation="AAVNAPLQTVLAG"
     CDS_motif       complement(18660..18767)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K9S39_RS12845_0003"
                     /evalue="1.60E-17"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="K9S39_RS12845"
                     /protein_end="149"
                     /protein_start="113"
                     /score="55.6"
                     /tool="antismash"
                     /translation="GVRPAALLGHSIGELAAATLAGVFSVHDAAHVVLDR"
     CDS_motif       complement(18789..18821)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K9S39_RS12845_0002"
                     /evalue="4.50E-03"
                     /label="PKSI-AT-M_m2"
                     /locus_tag="K9S39_RS12845"
                     /protein_end="106"
                     /protein_start="95"
                     /score="10.1"
                     /tool="antismash"
                     /translation="QPLLFAVDYAL"
     CDS_motif       complement(18951..18995)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K9S39_RS12845_0001"
                     /evalue="6.10E-05"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="K9S39_RS12845"
                     /protein_end="52"
                     /protein_start="37"
                     /score="15.7"
                     /tool="antismash"
                     /translation="PGQGSQYPRMTAGLY"
     gene            complement(19112..20190)
                     /gene="dapC"
                     /locus_tag="K9S39_RS12850"
                     /old_locus_tag="K9S39_12940"
                     /pseudo=""
     CDS             complement(19112..20190)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="dapC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008408431.1"
                     /locus_tag="K9S39_RS12850"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_12940"
                     /product="succinyldiaminopimelate transaminase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRAMPDFPWDVLLPHKRRAAEHPDGLVNLALGEPVDPTPEPVRRA
                     LASASDAPGYPPPKAPRCCARPPSAGSTAAWA"
     gene            complement(20187..20636)
                     /locus_tag="K9S39_RS12855"
                     /old_locus_tag="K9S39_12945"
     CDS             complement(20187..20636)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018571563.1"
                     /locus_tag="K9S39_RS12855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_12945"
                     /product="PPOX class F420-dependent oxidoreductase"
                     /protein_id="WP_248863474.1"
                     /transl_table=11
                     /translation="MDKDAKVPSFTPQEIAYIRTQTYGRLATVDARGEPHVTPVGFFFD
                     AENGLIDIVGRDMGNSRKYRNVQRNGRVAFVIDDIPCRDPETVRAVVVRGTAQALVTGG
                     RSHVPVCADEMIRIHPARVVSWGLTDASHPEAAPTEAEGAEASQR"
ORIGIN
        1 tgctcgacga cctcgctcag caccgccgcg tcatacccct tgagccggtt gtcggtgtac
       61 gccagcgacc cctgtacgag acgtatccgc tccgactgcc gctcgggcat ccggtccaga
      121 cgcagtcggc gccgggcttc gtgcagcgcc cgcatcgaca catccacccc gacgatctcg
      181 gtgaactgca tctccttgag cagcgcaccg accaactggc cctgtccgca gcccagatcg
      241 aggacccgcg ccgcacggga cccgcgcagc accgtgagaa tcgcctcgcg ccgctgtacg
      301 gcgagcggta ccggcttctc ctcggtgtcg gtctcctcgt ccaccgcgtt gtcgatctcc
      361 tcgacctggg cgtcgtcggc ctcggccagg cgttccagct ccagccgctc catggcctgc
      421 cgggtcagcg accggcgccg ggccagatag cggccgacga tcacccgctg ctccgggtgg
      481 tcctccagcc agccctcgcc ggcgcgcagc agcttgtcga cctcatcggg cgcgacccag
      541 tagtgcttgg cgtcgtcgag gaccggcagc agcacataca ggtggcgcag cgcgtcggcg
      601 agcctgcgct tcccgtccag gacgagccgt acgtagcgcg aatcgcccca ctccgggaag
      661 gtctcgtcca gcggaagcgg ctcggccagc accgtccatc ccagcggctg gaacagcttc
      721 cgtacgagtt ccgcaccgcc ccgggcaggc agcaccggca cctcgatacg caacgggagc
      781 gcctgctccg ccagttcggg acgcgccggg cactgtccct tcatcgcgct cgcgaagacg
      841 ctccgcagcg ccaccgccag cagtgaggag gccgcgtacg gccggtcgtt cacatactgc
      901 ccgagcgccg aatccggagc acctccccgg ccctttcccc tgccccggcg gaccagggcg
      961 atgggatcga cctccagcag cagcgcggcc gtgcaccgct cggcttccgc ctccgggtac
     1021 agcacatgcg cggtgccgta cgacgtcgag aactgctgcg ccttgtcggg atgcttgtgc
     1081 agcaggaatc cgaggtcggt cgcgggacgt tcggcgctgc cagtggtggt tatcgtcagg
     1141 aacacacgtc tgagtattac gtgacctgcc tcgatccccc accggttttc cggcagcagc
     1201 gacgattgat cgagcaggcc accgatgccc ccctccaaaa gcgcgtccat aagcccgccc
     1261 atgagccgtt ccatgagcac attcagggcc tcccccggcc acgcgcacgg cggggttgcc
     1321 acggccggcc aggcgctccc gccgggtcgt gccggcagcg atcaccaagg caatatgggc
     1381 ggcatggaac ttcgcatctt caccgaaccc cagcaaggag ccacctacga gacgctcctc
     1441 cgcgtcgcgc ggacggcgga agagctcggc tacggggcct tcttccgctc cgatcattac
     1501 ctgcacatgg gcaatgtcga cggactgccc ggccctacgg acgcctggac caccctcgcc
     1561 ggtctggccc gcgagaccca gcggatccgg ctcggcacgc tgatgacggc gggtaccttc
     1621 cgcctcccgg gcgtgctcgc cattcaggtc gcgcaggtcg accagatgtc gggcgggagg
     1681 gtggacctgg gcctcggctc cggttggtac gcggaggaac acgccgccta cggaatcccg
     1741 ttcccgaagg agaagttcgg ccggctcgaa gaacaactgg cgatcatcag gggcctgtgg
     1801 gacacgcctg tgggcgagcg cttcaccttc gacgggaatt tctaccaact gcaggattct
     1861 ccggcgctcc cgaagcccgc acagtcgcat gtgcctctcc tcattggcgg gcacggcgcc
     1921 aggcgcactc cggctctcgc cgcgcagtac gccgacgaat tcaacattcc tttcgcatcg
     1981 ctggaggaca cggagcggca gttcaagcgg gtacgggcag cggccgagga gcgtggccgg
     2041 aaggcggatg atctcgtcta ctccaatgct ctcgtggtgt gtgtgggtaa gagcgacgcg
     2101 gaggtcgagc gacgcgcgga cgccataggg cgggaggtcg aggaactgaa ggccaacggg
     2161 ctcgcgggct ccccggccga agtcgtggaa aggctggggc ggttcgcggc cctgggatcg
     2221 cagcgcgtct atcttcagat gctggatctt gacgacctgg accacatgga actgattgcc
     2281 gcggaggtca tgccgcagct ttcctgaaca ccgggcgtcc cgtcggacga gccgcgtcac
     2341 acccggcggg acgccgaccg gcgcaggagc ggtggcactc cccgcgcatg gccggacgga
     2401 gcaacgggcg tgggggcctg ggcgtaggca cgagcgtggg cgtaggcaca aacgcgggcg
     2461 taggcatggg ctccggcgtg agcgctgctg gactcacgat cgagtggcac cgccgattca
     2521 gccggcgcgg aaccactcca ggacgggccg gtgcaccatc aggcgaggtc cctgtcgcgc
     2581 acctccagct tttcgagtat tccggccacg cggtccctcg actcatcggc catgtcgatg
     2641 gcctcgacac aggtccagta catcccctcc tcatccgcgg tcgacaccac actcaccagc
     2701 gcctcgcaca cctcttgcag caattggcac atgccggcca aagcggcctt gacatcacgc
     2761 acttcggaca gctgagccgc ccgcagccca ccggtcgcag gccccgagca cagcagtccc
     2821 ccgctgaacc gcccgcccgc gtcgcccaac ccgcgtgctc tggaccggac ttcatagggc
     2881 ccgaatatcg cgagatggct accgatcgcc tccgacaaag cttgcgcttg ccatgcttcg
     2941 acgaccacgt catgagccgt gcccgcctgc gccagaccgc gccggttggc cgcgatgatc
     3001 cgcaccgcgt ccatccgcgc cccctccttc cctctccgtc actttcacct acactctttc
     3061 cactacccag agtgagggtc aacacccaaa aacgccaggg gaattcgcaa atctgtggac
     3121 aaccaaggcg ctgtggagag atccatgact ccggagagtg acaaatggcg ggttcagacc
     3181 cgctcctccc ccttgcgcca ccctgtcccc gccaaccgcc ctgccactac aggccacttg
     3241 aaccgccgcc gacactaccg tcacgccgat ccacgcgatc cccgcccgtc ggccgacata
     3301 ccgcgccagg aggagagggc acgcctcagc agggaggaag tgcacgtctc ggcaggaagg
     3361 cggcagggcg cgcccggagc cccgcgcacc tctcccgtgc cccggctgcc gcccggccgt
     3421 tccctacccc tcgctccccc gcggccggtc cgggcgtgcc gagggccccg gcgggaagcg
     3481 tgactcattg cgttcgatct tcgcggcgag tgccgtcagg gcatcgatcc ccagggcctc
     3541 acagaactgc agcagatagg ccagtacgtc cgcgacctcg tcctcgaccc ggccggcgcg
     3601 ttccgggtcg gacatgactt tcgccgattc ctcaggagtc aaccactgga agatctccac
     3661 cagttcggcg gcctcgacgc tgagcgccgc ggccaggttc ttcggggtgt ggtactgctg
     3721 ccagtcccgg gccgccgcga aggcggcgag tcgtcgctgc agggcttgaa gatcctcact
     3781 cataccccca ggtgtagcac ccgtacatcg ggcagcccct cggcgaccga cgggtcgcgc
     3841 accgtcccca gcagacggac atgcccccgc tcagtcatcc gtacggccag cgacaccagc
     3901 tcccgcgcct gccgctggtc catgcaacgg tccatcccgt ccgccaggac cgtcagctgc
     3961 tgctgagccg acgggatctc cccggccggg tccatggcga gcacccccgg gccggtgagc
     4021 agcaccagcg ccagcgcgac aaaccgcagc tcaccgtccc cgagctgctc gatgggcagc
     4081 gcccccaagg caccccggtc gatgacggcc cgcatgccct gtgagccacg ccccgcctgg
     4141 gacgcgtcca ccatggggga cccgctcacg gcctgagccg cctcagcacc tcgtgacggc
     4201 tgagtcagct gagctacccg gggcccttgc gccccctggg ctgccggcgc cgacccgacc
     4261 ccggccttct gccccacccc gggcccggca tccaccgccc cctcggcact cccctgccgc
     4321 ggcaccgccc gcagcccgtc gacagggccg gtggacgcct cccgtacggc cctgaccagc
     4381 acctcatgcc gtcgcctgca ttcgcgactc gtacggtcca gcaccgcggg aaggttgtcg
     4441 caggacggcc tcagccgccc ctcatccacc acttcctcgt ccccgtcacg ccgccagtcg
     4501 ccggattcgc caccgccccg gcgcccggca cgcgcacccc cgcgcccggc cccacgggat
     4561 cccccggaac tcccctcccg gccaccccca cgagccccgt tccgcaccgc acctccccca
     4621 ccggaaccgc cgtggccgtc acccccaccc tgcgcagcgt ccccacccct gcccgccgcg
     4681 cgcatcactt ccggccgggg atcgcagacg aacgctgacc ggagcgcgac cacgacctgc
     4741 tccgccgcgg ccaggaccag tcgctgtccc gccgtcttgc ccgcgacgcg caacggcagc
     4801 agcgaggtgc ccagccggtc gtcgggcagc ggcgcacgtg tcaccggagt ggcacccgcc
     4861 gtgtgccagg ccgcttggac ggcggggcgg gacggatcgg tgagggccgt ggtgagcagc
     4921 gtctggccgc caccggtcaa ccgctcgccg acgatgcgca gttcgggctc ggcctgcacg
     4981 gcgagatcga ggctgaccgg gccggccggt ccgtcgaccg tgcagccgat acggaaccca
     5041 cgccgcccct ggccgtcggg gcgggcgccc gccggaacgc atgccgtcgc accgcccgcc
     5101 accacctcga cggcccgcgc cagccgctca ccactgccga gcctggcgag gatctcgtaa
     5161 gcctgaagcg cactggactt gccgctgccg ctctccccgc tcagcagcgt caacgggccg
     5221 agcggcaaag tgacgcctcg atgggacttg aaggcggaca gccgtaattc ggtgaccgcc
     5281 ggccgcacac tgtcggtatc catgtgggga cgctatgcag cgccccgcac ggagaaccgt
     5341 tacgcccgac agctcttcct acgaacgggg gacggtaccg cccgccgcct cggcgacctc
     5401 ggtgccgatc ggcgccagca ggaacacatt ggtgtcgacg cggtgcattc cgctgccgag
     5461 cccgaagaca accccgctgg agaagtccag gatgcgcttg gccacatcgg tgtcggcgct
     5521 gctgaggtcc agcaggaccg ggatctgcgc catgaggtac tcggcgacct cgcgcgcgtc
     5581 cgcgaaggtc tgcacgcgga tgacgatgaa ccgccgcatt tcctccgccg gttcctcctc
     5641 ggggagggcg cggtggtcgg gccaggacgg ccattcgctg ccgctgcgga gcgggacgac
     5701 ctcggcgagc ccctcccact gctcgtcggt ggcatcgggg tcgttcaccg aatcacctca
     5761 cccagagggg cactgattgt ctgcggcggt atctgcatcg cacgattcta gggataaaca
     5821 cacaaagctt gtcacatgcg acacgcggcg ccgcacccct gccccatcct gcaccatggc
     5881 ccctgaccag tgccgacgac gtcggcagat atcttgcgtc gagtttgtgt gtgcccgttc
     5941 atcccccctt gtgacggagg tcggtacagt cgtccacgct gggcctcccg tagccgcagc
     6001 acctcacgcg tttcttgctg ggtatcgtgg cgccacgtgg gcgacagcac tgtatggacc
     6061 gtggcgatcg cggcgctgac cggtggcacc gcggtgctcg ccagttgggt caccagccgc
     6121 ggcagcaccc aggccgccag aatccaggcg gagatagtcg cgcggtcgca gcgtgccgag
     6181 cggctgcgcg agagccggcg tacggcctat ctggatctga tcgaacagac ccaccggatg
     6241 ggcgagttgt actgggagat atccgcgtcg ctgcggctgc ccgaatccgc tgaccgtacg
     6301 gcagctctcc acgagctgta cgaccgggag atcgccgagt atgcccggat gcgccgctgc
     6361 gcacgcgtcg tggagctgga gggcccggcc gcagcggccg cggcggcgct cgccctccaa
     6421 aaggccaccg gtcccttctt ctcggctttc aaggccgagt tggatggcaa cagcggtgcc
     6481 cgcaacggcg atacggacaa ccagcgcgac aaccacgaag agtttaacgc cgcctacaac
     6541 cccttctgga aggcgctgga ggacttcgtg gacgcggccc gggacgccca ccagaacggc
     6601 gagggcgcct gagctctaga gggtgtcgtc gagcaggtcg gtgacgaact ttcgcagtcg
     6661 cccgtccact acgggagtga cgccgtgcag cacctgggcc ccgtaggcga cgacggtgcc
     6721 cggccccgca tcgcacatcc accgggtacg gtgcgcgcgc tgaagccatc ccggctgctg
     6781 gtcgtgctgc tgcaacccgt gtgttccggc gggaaggtgc cgggtgagcg gagtgtccgg
     6841 tgcgaagccg tcctccggac cggcgatccg gccgtcccag agcaccgggt cggacgatgt
     6901 ctcgacgtag aatccgccgc cccggtcggc gtcgtcgagg accacgccga tccggcccga
     6961 gcggcgcggg cgggccgccg ggtccacgat cccgtcgata tgcgccggca cgctctcgcc
     7021 ctcccccagt tccgtgtacc cccagggcgc ggcgctccgc accgacggga gcacacggcg
     7081 cagcacgggc agcgcacgct ccagggcact gtgcagaatg tcctgtgcct cttccggcgc
     7141 ctcgaccact tgcgcctgga aggcgggccg ccagccgccg agtccggtgg ccacgatctt
     7201 ccgcagctga gtgagttcct cctccgtcag aaagttctcg accgtctgca gtgccagcgt
     7261 ctgccccacg gtaatcacgg cacgccccct tcgaagagca ctcgtcggtc cgatcagggt
     7321 cccgccggat ccggcaggcg ctgcagggcg cgaagcgcca cgtcgacgca gaacggcgca
     7381 gccggggcgc ccacgcccgc gcgtacgacg gggtccgccg cttacgcgaa ggggggcacg
     7441 gggtcggctg ggtagtctcc gcgccctgta cggtgcaccg tcgtccgtgc ggggtcgctc
     7501 cctgccccgc ctatcgcggt cgtacgctgc ccagccacag aacgtcgcgg gcgcgggtca
     7561 tggcgacgaa gagctggctg cgggccagtt cgccgcgttc acgtgccgtc tcggccgatt
     7621 cggggcccgt tggcacatcg gcgtcgtgca gcggcagata gacacgcttg aattccaggc
     7681 ccttggcgcg gcgatagctg ccgagcttca cggcctcgac ggtgtgtccg tcgtagtgct
     7741 ccagcaggca cacgcgtatg ccggcctggg tgagaaggcg ctggtagccg tcgatggcgc
     7801 gcttcgacga gcacagtacg gcggcgtccg accgctcctg gggtgtcagc tcgcgcaggg
     7861 ccgccacgag cgcctggtcg tgttcggccg ccgtcggctt caccacgcgg tgcacccggc
     7921 cgtcgtgata ggtcaggtcg acgtcccgtc gtcccggggt acgaaggccg tcgatgtcct
     7981 cgaaggagtc ctcggcgacg atggccagcg cggcgtccac gatctccttg ctgttgcggt
     8041 agttggtacg gaggacctgg ccgcggtcgc cacggatgtc gacgcccgcg tccgacagcc
     8101 ggaagccacc cgggtagacg gcctgctggc cgtcgccgac caggagcagg ccgttgggtg
     8161 tgtcgccgac cagggcgtac agcagccgca ctccgacgag tgtcagatcc tggacctcgt
     8221 ccacgatgac ggcccggtag ggggagtcgc cggcgccggt cgcctcttcc agggcgaggg
     8281 agagaatgtc gttgaagtcg tgcacggcgc gctcggtccg gtgggactca tacgcctcgt
     8341 acagcgccca gaccgcccgc cggtgagcgc gtcggagggt ggtccgtcga cggcggcggg
     8401 cgacggcggc gtattcctcg aacgaggcga tgccgcgccc cttgatgacg tagctgatct
     8461 cttcgtgcca gtagtgcggg gacgggtcga tctcggccag gcagctgtcc cgtccgacgt
     8521 ccttccaggc gaagctgaaa gccgtctccg ccctcgcctt gttcagctgg accggcacac
     8581 cgcgtccctt caggaactcc tgggcccagg agtgcaggct gcggaagtcg atccggtccg
     8641 ccacggccgg ggccatggtc ttcagaaagg tgccctgcac acggggcagg ttgttcgcga
     8701 aggtgacgta caggacccgg ccggtggtgt gccgggcgag gtgggccgca cggtgcagtc
     8761 cgacgaccgt cttgccggtg ccggccggac cgctgatacg ggcggggccg gcccagttac
     8821 ggcgcaccag cgcgacctgg tcagggtgca gaaaggtcat ccactgttcg atgggcgcct
     8881 gacgtgcctc gtccagcgcg gcctggcaga ggccgtcgag gtcgaagagg ccgtcgggct
     8941 ccgatcccgg ttgccgtgga cggctgcgcg acggaacggt ccgcgcgggc gcccggtctg
     9001 actgccccgt ccgtccggcc accgggggcc acgagtttcg tgcggcttgt ggggtgcgtg
     9061 cggactgtgg ggttggtgcg cctcgggccg gcgcgctccg cttcgcggac gggtcctcgt
     9121 actcggggaa gacccgctcc agatgctcgg cgatggcgcg cacctgcgcc gcggagagcc
     9181 gggtgcgctc acgcagcagc gccggtccga tctcgtactc gcccagcagc cggatccgcc
     9241 ctaactcgac gttgacctgc cgccccacga aggccatgac cggctgcacc gccaccgggg
     9301 acaggcccag cgaggccacg gcgccctccg ccgtcttcgt caccgccagc agcttgcgcc
     9361 ggtgctcgtc gcgcgactcg cccccggcgc gcagctcacc gtccgaagtc tccggagcgg
     9421 cctgccagtt cttgacgtcg acgacgaaga caccaccggg gccgatcagc aacatatcga
     9481 cattggccgc gcgggtgccc ggccatcgcc ggtcgacgag cagccgccag ccccgctcgg
     9541 tcagcaccag cagctgcgcg gcgacccgcc gctcgccctc gctcgccgcc tcccagcgca
     9601 gtgcccgctg ccgggccgcc cgccactgct cgcgcaacag ccgttcctgg agccgggctt
     9661 cctgagcccg acgtgcggcc gaaccgcctg ccgccatgta ctcgcccccc tcgtacgcgg
     9721 agtagtgacc ataggtcgtt gcacggtggt gcaatagctg ccgtggggtg gcgccgagct
     9781 gcagaccggc gccccagcgg ctcggcgaag gctcggtcac gcgtcgtatg aggggtctca
     9841 tgccggtcgt ttgacggttc gtttgacgcg tcgtctgacg agtggtttga cggttggtgt
     9901 gacagttggt gtgacggggc ggtggcaggg tcgatgacag gtcggcggag gcgccgggaa
     9961 gccatggtgc ggtccggcgt cccggcgccc ccgcccggcc ctacccggcg ctcaggctca
    10021 gcagcgacgg aaggatgcgc gcggccgatg tacccagtcc cgtcggtccc ccgggccaca
    10081 tcggtgacac cggtccgtgg ctcaggtact cctcgcggta acgacggcag tcccggtgcc
    10141 agttgaggat cccggccatc cagttctcca gctctttcac atacccgtcg agtgccgcac
    10201 gcgcttcccc ggagagattg aagtcgtcgt agacgatggg gagttcgttg gcggcgacat
    10261 gctggaactc gcgcatacgg gacgtcatca ggtcgtggac gatggccagc gcggccgggt
    10321 agtcgcagtc gaagaagttc tggaccacga ggagggagtt gtgcacctcg ccctcgtact
    10381 cgatctcctt ctggtaggag aagacgtcgt tgagcaggca ggcgtagtcg acggcggagt
    10441 tctccagtga gcgcatcggg ccggtgcggt agatctcggg tgggaccgtc cgcccgtgtc
    10501 cgatgcggct caggctcatg gtgaggtcgg caccgaaggt cgcccggcgc atctcgatgt
    10561 agtcgaccgg gtcggggata cggttcagcg cctggttctc cagttcccag agccagctgg
    10621 agatcatggt ctcgacggcc gcacggaacg aacggcgcgc gtcgggggac atcgggcccg
    10681 ccgtacggga ccacaggtcc gccaggccgc gttcgagggg ggtgaccggt gcggtcgtcg
    10741 gggccgagaa gtcgaccgtc atcagctgcg acaggcgctc attgcatgcc ttggccgggg
    10801 ccaggtcgcg ggtccggccg aagaccgcgg ggtagtagtc gtccgcgtag gtgccccagg
    10861 caagccactg ggtgcccaga tcgagttcct ccagggtggc gtccgggtgg aggcccgccg
    10921 cgcagagggc gagatcgtgc cgcttgatcg cgggctcgtc ccagatgccg gagaagggca
    10981 cgccgggctg cggccggagc atgcccatgc ggtgcgccca tgcgatgacg ttgcggcggg
    11041 acgtttccag gtgcgggctg agggtgaggg tgaacggcat gtagatgtcg gggatcttgg
    11101 acggcccgac ctttgtgtac gggacgtggc tgtggctgcg ggcacgccgt ccggcggccg
    11161 tggccagggc cctcttcagg tccgccgccg aagtgcctag gccgctgacg gcgaagggcg
    11221 accaggacgc ggatgccgcg gaggacgaca acggggcccc cgccgccgct cccccgccgt
    11281 tcatgtaccg gctggagcgc atatgccatt catggccgcc ggactgccag tcctgcagcc
    11341 ccttcgcgta cgccagcacg tccgcgcagg atttcgggtc gagccccttc tccacgaaga
    11401 gcgcggggag ttcacccagc accgtgttct cgaactgctg gagacgcgag gtgatcaggt
    11461 cgttgacggc gtccgcggcc tcctgggtgg tgcagtccag gaatgtctcc aggaccagaa
    11521 cgccgttgct cagctctcct tcgtcctgcg tttcccgctg gtaggagaag aggtcgttgc
    11581 gcagatggac gccgtcgcaa aaggtgtcct tgaggacccg caggggacgc gagtcggcca
    11641 cggccgcggg aatttcggcg ccggccgcga actccaccag gcccgaggac cacggcgctc
    11701 cgccgacctt ccgccgcatc tcgatgtact cgacgggatt gggcacgcgg tggatgttga
    11761 tattcgccag ttcccacagc gattcattga gcagatgctc ggtggcctcg gcgaaccgcg
    11821 cccgccacgc catggacata tgcggcacgg tgcgctgcca cagatccgcc aggccggctt
    11881 cgacggggtt ggtcggctcg ggcatgggcg tcgccagatc catcggcata aaggccggca
    11941 gccggtccag atatgccttg ccgccctcgc ggtcctgcgt ccgcttgaac ttctccaaga
    12001 aatggtcgtc gaagaagaag acccacacat accagtccgt caccatcgag agcgcctgct
    12061 ccgaggcgtc cggatgggtg tacgaacaca gcagggcata gtcgtgggcg tcgaggtccc
    12121 gttcctccca gatgtccgag ccttcgagca ttcccatgcc gcgggcccac ttcttcgagt
    12181 gtttccgggc cgattcgaga tgcgggttca gccgcgccgg atgagggacg tagaagttcg
    12241 gcaattcgaa tggctgtgtc gtctgcgtcg tctctgtcat cgctgctgac ctctcccgat
    12301 acgcgcggag ggaaggcgcg gtgcggtacg cccccctgac gtgcacagca ctaccccggg
    12361 gggtgccgtg gtaggccggg tccatcgaga catcagcgtt gatcggcgtt gagcagcgtt
    12421 gccgttttcc gtatctcgtg cgcgcattcg agccaatcgg gcccattcga gctcatgagc
    12481 ggtgtttcgc tgatgggttg tgcgtgatgc gtgatgcagg tgtgtgatgc atggtgcagg
    12541 tgtgtgatgc atggtgcagg tgtgtgatgc atggtgtgtg atgcgttccg cgttccgttg
    12601 atgcgttctg cgtcgtcacg gtgaaccggg actcccaggg ctccggacaa cagcgccggc
    12661 agcgcctgcc cgggccccct ccggcacacc acccggtcga tcagcagcca cttcgccagg
    12721 acgcccgcga cgaccattcc ggtggcgggc gccgtcgacc cgaaccgtac cgtcgcccac
    12781 accgcgcacc cgccccgcgg cacggtccgc ccggcgagtt cggcgagcgt ggcggccggg
    12841 tcgagggggt gtccggcggc cgtcagcagc cccaccaggg tgagagctgc gagccccgtg
    12901 acggcggcgg gccaggcgag gcggcgggcg acggtgcgcg ggtagccggt cggcagcgag
    12961 aggtgcagcg cggccatcgg ctcccgcgcc accgccgcgg cgcaggccgc gccgcggcgg
    13021 ccggaggcgc gcaggtcagc agcgagcggc cgaggagcag accggcgtcg gtgcgcacga
    13081 ccatcgacgc gtacgcgagg agcttcggca gcgccgacag cgcgtaggac tgccgtccac
    13141 agcggcgtac ctcgtgggac catcaagtcg cggcggccat tgcggagttc ctcccgagtg
    13201 tccctggccg ggctgcaacg gtggaacggc atatgcgcag caccgcatcg atcgaggcca
    13261 tgactcgggc tgccacggcc ctgacatccc tggggggcac agctccggga cgcgggattc
    13321 accgcgcacg agatcagcgc gcggctcggc gtacccgaca tccgcgaggc gccggccaac
    13381 gcggcctggc actccttcgc ccagggccac agcgacgaac cggccgagcg ccggtgacgt
    13441 cctgctgcgc ctgttcgcac tgaacctccc ggtgcccttc gggcagttca cgcccctcgt
    13501 acccgccgct gcgcgcggcg ctcacggatc tggacatggt gcggcccgcc ggggagtgca
    13561 ccgagaccgc cgcctgtgtc gaggcgacgg tctcgctctc gccggtctcc gccgatacgg
    13621 tcgtcggatc gccgctccgg ccgaccaggt ctacgccctc atccgcgacg ccgtggactg
    13681 gccacagcac ttcatcccca ccctccacgt cgagcgcgcg gccctgggcc ccgacagcga
    13741 gcgcctgtgg atctgggcca ccgccaacgg cgacgtcacc cactggacct cgcaccgcac
    13801 cctcgacccg aggcggcggc ggatcgtctt cgaacaggag gtctgttccc cgcccgtggc
    13861 cgcgatgagc ggcgaatgga cggtcgacga cggcccggac ggcggctgcg agctggtcct
    13921 gcaccacacc ttctccgccg tggacgacct cccggagaac gtcgactgga tcacctcggc
    13981 caccgaccgc aacagccgca ccgagctggc caacatcagg gccctggccg agaacgccca
    14041 ggccgacgcc gaactcctct tctccttcgc ggactccgag acggtgcgcg gcccctccga
    14101 gcaggtctac gcattcctcc aggaagccgg cgcctggccg gaccggctcc cccacgtctc
    14161 ccgcctcgac ctccgcgagc cctccgaagg actccaactg atgacgatgg tgacccgcgc
    14221 gggcaatggc tcggagcaca ccaccgagtc ggtgcgggtc tgcttccccc acgaccggat
    14281 cgtctacaag cagctcacca cgccccctct gatggccacc cacatcgggc agtggctgtt
    14341 gcaggagacc gacgacggcg tgtgcgtcac ctcccaccac accatcaggg tgaacgaggc
    14401 ggccatcccc gccgtcctgg gccccgaggc caccccggcg accgcacgcg actacctccg
    14461 cgaggcggtc ggcggcaaca gcgctgccac tctctccctc gccaagcgct tcgcagaggc
    14521 cccccatgcc gtctgagccc ggcggccccc accccgacgg tgaccgcgcg ccacaggtgc
    14581 tggtcgccgg cgccggaccg gtcggcctca ccctcgccca cgaactggcc cgcaggggag
    14641 tacgagtacg ggtcgtggat cgggccgccg gcccggcgac cagcagccgc gccctggccc
    14701 tccatccgcg caccctggag ctctgccacc aaatgggcct ggctgacgcc ctgttggagc
    14761 gcggccgtcg cgtcacccac ttcaccctgc acctgcgcgg ccgcgagctc atccgcttca
    14821 acaccaacta cacgcggctg cccaccgcct accccttcag cctgatgctc gaccaggtcc
    14881 acaccgagga ggtgctccgc actcgcctgg cggagctcgg tgtccggatc gagtgggggg
    14941 tggagctgcg ggactgtgtc acagagggcc cccacgtcgc cgtacggctg gggcacggcg
    15001 accgcacggc ggagctcacc gtcccttggc tggtcggcgc ggacggctca cgaagtaccg
    15061 tgcggaagcg gctggggctg cggctggtcg gggacgccac ccagacctgg ctcaacgcgg
    15121 atgtggtcct cgacgtcgac ctccccccgg acagcaacca cttggtgcac accggatccg
    15181 gaagcgtgct gctcgtcccg ttcccggagt cgggcaagtg gcgggccgtg gacactgagt
    15241 acgcccggta cgaccgcggt ggggagcggg gggacggccc ggaagtggtg cgccgccggc
    15301 tggcggaggc cctctcgcgc ggcctgggcc gaccggtcgc ggtcgccgaa ccgacctggg
    15361 tctccgtctt ccgtgtccag cagcgcatga tcaccgcgat gcgggccggc cgctgcttcg
    15421 tggcgggcga cgcggcccat gtccacagcc cggcctccgg ccagggcatg aacaccggga
    15481 tgcaggacgc cgtcaacctc gcctggaagc tcgcccaggt ggtgcgcggc gaggcggacg
    15541 aggcgctgct ggacacctac gccgccgagc gcgtcccggt ggggggccgg ctgctctcct
    15601 cgacgcggaa ggccacggcc ctggtggcgc tgcgcaacgc cgccgcaccc gtcctgatgc
    15661 cggtggggct caccgcactg cgggcgctcg gacccgtcaa gcggcgcgtc gagcaccggt
    15721 tcatggcggg cctgtccgga ctggcgctgc actacgccga tagcccgttg agcagtgccc
    15781 caccgtcctc gccccagcgc ctgggccggc gcggcgccgg tgtcgagccg gggcaccggg
    15841 tgggctgtac cgcgcgggac gcggcccgcc accctgggtg gtgggcgctc cgtcaggccc
    15901 tcgccgaccc ccgctggacg ctgctccact tcagccaatc tgcagccgaa cggacatccg
    15961 aagaaggcga tttgactttc ctggtcgagc ggtttggccg cgccgtccgc gtccacgagg
    16021 tgcaccctgg cggccggtca cggagcaacg ggggcgccat cccggaccca ggcggtgtcc
    16081 tgcggcgcac cctgggggtc ccagccggcg gctacgcgct catccggccg gacggctacc
    16141 tggcggcgaa ggggccgcgg gccacggcgg acaccctgac cgccgccctg cgcgccgtac
    16201 acctgctctc cgacgtcgac gccccccaac tcccgacgtc gacgcccgca taacacccac
    16261 gcgagaaccg caagacaccc gatgcctcca cggcacggca gagaggaata cctggggatg
    16321 acacgaaggg aaagcgacga cccggccgcc gcgcacggct ccgtggcgct ggtcaccggc
    16381 gcaacccgtg gtcttggcct ggccatcgca tcgaagctca ccgccgccgg ctgcgaggtc
    16441 ctgctcaact atgcccacga cgagagcgcc gcgcgggccg ccgaacgggc cctggccgag
    16501 gccggtggca aggtccggct gctgcgcgcg gacatcggcc ggcccgccgg cgtcgtccgg
    16561 atgctcgacg aagtccggcg tgtacacggc acgttggacc tcctcgtaca cagcgccggt
    16621 acctaccatc cggcaccggc cgcggcgcca cacatcggcc gcgcgctccg cgacggcgca
    16681 gtggcgctcg gaccgctgct gtacggggcc gggcggctga gcgacctgat gactccgggc
    16741 accggacgga tcgtcgccgt ctccagcacc ggtgcccact ccgtcgtccc cggctacgcc
    16801 ggcctgggca tggccaaggc ggctctggag accctggtgc gctatctcgc ggtcgagttg
    16861 gcggaccgcg gcgtcgccgt gaacgcggtg gcagccggca agctcgccga cggcgcctcc
    16921 gccgtgctgc ccgccgaagc ggtggcgggg ctggtgcggc gcactgcggt gggccggctc
    16981 accgctgccg tcgaagtggc cgatgtcgtg gggctgttgt gccgcccgga ggccggcggg
    17041 ctccatggcc aggtgctgac cgtggacggc ggcgccagcc tccgctgagg ggagaggaac
    17101 ccacaccatg cgcatcatcg atctgtcgac gaccgtggac gcctcccagt gggaggtgga
    17161 cccggtcatc cacgaggtgc tgaccccggc cgagggcggc cggcacatgg ccgaggggat
    17221 gcggcgcaac cacggcgtcg ttttcgaccc ggccgagctg ccggacggcg agctgctctc
    17281 cctggacacc ctcaagctga ccacccacac agggacccac gtggacgccc cctcccacta
    17341 cggctccagg gccggctacg gcggcacccc acgccacatc gaccagatgc cgctcgactg
    17401 gttcctgcgg ccggggttcc ggctcgacct caccggcgag ccggtcggcg ccatcggggc
    17461 cgaccgggtg cggcgcgcgc tcgacgcgtg cggctgcacc cccgccccga tggacatcgt
    17521 gctgctctac accggagcgg accaactagc cggcacgccc gcctacttca ccgacttcgg
    17581 cggcctcgac gccgaggcca cccacctcct gctggacctg gggtcaaggt catcggcacc
    17641 gacgcgttca gcctggacgc gcccttcggc cacatgatcg acgcgtacca gcggaccggc
    17701 gaccgcgggg tgctctggcc ggcgcacttc gtgggccggg aacgggagta ctgccagatc
    17761 gagcggttga gcaacctcgg ctccctcccc ggccccaccg gcttcctggt ctcctgcctc
    17821 cccgtcaaga tcgcaggggc gggggccggg tggacccggg ccgccgcgct cgtcgaagag
    17881 gagccggccg ccgaggagcg gtgcccggac cgcgccgacg gatgagccct tgaggcagag
    17941 agcgccacct atctctccct gcctcatacg tacctcccac tacctcaagg gcgccccgca
    18001 caccgtgcgg ggcgcccttg ggtctgtccg atgggatggg ctcaggcgcg gggctccagc
    18061 tcccgccgca gcgcctgacg tgccgcatcc aaggtcgcca cctcgtcctc cggccctcgt
    18121 acccgccgtg gggagagcgg caggacgcca ctgtcccccc ggcgtacggc ggggtgctgc
    18181 cgggccagaa gggagagtcc acgccccggc ccagcctcga ccagagagaa ttcgccggac
    18241 gccaacaacc cctggagtgc gggccagaag cgcaccttcg cgaccggctg ggccgcccag
    18301 tacacggggt ccgcgatctc acgggcggtc agtggcgcgg ccgtggcgca cgagtggatc
    18361 ggcaccgccg gggagtgccg cgccaccgag gccagcaccg cagtggcacc catggcgtac
    18421 ggcgcgatgg ccgggctgtg gaacggactg agcgccggga cgggccgcac cgcgacgccc
    18481 cggacacgca gccgctcgcc cactgcgcgc agcgcgccct ccggcccggc cagcaccgtc
    18541 tggagcggcg cgttgaccgc agcgaccacc acctcacagt cgaggaacgg cgccagctga
    18601 tcggcggagg cggccaccgc gatcatgccg cccggcgggg agtgcgccag ccgcaccacc
    18661 ctgtccagta cgacgtgcgc ggcgtcgtgt acggagaaaa ccccggcgag cgtggccgcc
    18721 gccaactcgc cgatgctgtg gcccagcagc gccgcggggc gcacgcccca actctccacg
    18781 gtccgcccca gggcgtagtc gacggcgaag agcagcggct gggcccgcag tacatggtcc
    18841 atgggcagct ccgactgctc agccagccag tccgcgcgga tgcgggcccc ctccctgccc
    18901 atcgcgtcga agacctcgtc gagcgcctcg gtgaatgccg cgaccgtgcc gtacaggccg
    18961 gcggtcatac gggggtactg ggagccctgc ccgggcagca gcagcgcgac cggtcgggac
    19021 gcatgccgcg cggcggctcc gcgacagcgc gcacgatccg ccgcgctggc cgccgtgacg
    19081 ggcccggcca ggggagtctg gggcacctct gtcatgacag tcgggcggct gcggccgcga
    19141 tccgctcgtc gctcgccgtg aacgcgatcc gtacgtgctg ctcgccagct tccccgtaga
    19201 aggtgccggg cgccacgagc aggccccgat cggccagttc cttcacagtc acccagcacg
    19261 actcaccgcg ggtggcccac aggaacagcc cgccctcaga gtgctcacag cggaaccccg
    19321 cggcgtgcag ggcctgttgg agggtgtggc ggcgccgggc ataccgggcg tactgctccg
    19381 ccacgtgcgc gtcgtcgtcc aacgcggcca ccatggctgc ctggacgggg gcgggcacag
    19441 cgtgcccggc gtgcttgcgg atccgcagca atcgctcgac caggcgcggg tcaccggagc
    19501 agagccccgc gcggtagcca gcgagattgg agcgcttgga gagcgagtgc accgccaaca
    19561 acccctcgtg gctgcccccg cacacccgcg ggtgcagcag cgagatcggc tggtggtccc
    19621 agccgtactc gatatagcac tcgtcgttga ccacgaccgt gccgcgctcc cgcgcccagg
    19681 ccaccaggtc gcgtagctcc tcctcgccca gcactctgcc ttcagggttg gagggggagt
    19741 tgagccacag cacccgcacc ggttccgtgc ccaggtcccc cacggcagcc accggccggg
    19801 aggcggcgcc ggccagccgg gcgctgacgt cgaaggtggg gaaggccagg tggggaaagg
    19861 ccacggtgtc gccggtgccg gcgcccagca tggccggcag ccaggcgatc aactccttgg
    19921 ttccgaccgc gggcagcacc gccgacggcg cgaccgtcac gcccaagcgg cggtggagcc
    19981 agccgacggc ggcctcgcgc agcaccgcgg tgccttcggt ggggggtagc ccggcgcgtc
    20041 cgaggctgag gcgagggccc ggcggacagg ctcgggggtg gggtcgacgg gttcgcccag
    20101 ggccaagtta accagtccgt cggggtgttc ggccgcccgg cgcttgtgcg gcaggaggac
    20161 gtcccagggg aagtcgggca tcgctctcat cgctggctcg cctccgctcc ctcggcctca
    20221 gtcggggccg cctcggggtg cgaagcgtcc gtaaggcccc aggagaccac ccttgcgggg
    20281 tgaatgcgga tcatctcgtc cgcgcagacc gggacatggg acctgcctcc cgtgacgagc
    20341 gcctgagcgg tgccacggac gacgacggcg cggacagtct cggggtcccg gcagggaatg
    20401 tcgtcgatga cgaatgcgac tctgccgttc cgctggacat tccggtactt ccggctgttt
    20461 cccatgtccc tgccgacgat gtcgatcagc ccgttctcgg catcgaagaa gaagcccacg
    20521 ggcgtgacat ggggctcgcc ccgtgcgtcg accgtcgcca gccggccgta ggtctgcgtt
    20581 cgtatatagg cgatttcctg tggggtgaaa gacggcacct ttgcgtcctt gtccatagcg
    20641 agcgggtcac cggcacgcta cggattccgc ttcgagcccg tttcgaggcc gcgcacccgg
    20701 attccggctg gaccccggct cgaaggccca aggccaccat ggcgttcgcg acttcccctt
    20761 gcgagctgtc cgcttgcgaa acttccccta gcagaaggag ggcagatgcc gtacgacgtg
    20821 gtcgtggtgg gcgccgggcc caccggactc atgctcgcct gtgagctcca actcgccgga
    20881 tcccgaaccc tggtcatcga acgcctggag cggccggccg acttctccaa ggcgctcggc
    20941 gtccacgcgc gcacggtgga actgctcgat ctgcgtgggc tctgcgcgga cttcctgcag
    21001 gacgcccgga aacttcccgg cggcaacttc gccagcctcg gtgtgcccct ggagcttacg
    21061 cccttcgaca ccgagcaccc ctacgtactg ttcgtccccc aggtccgcac agaggagcta
    21121 ctgacgcggc gagccctgga gttgggggtg gagctacggc gcggccacac cctgaccgcc
    21181 ctggagcagg atgaccagag cgtgacggcc acggttaccg gtcccgatgg gcccacccag
    21241 atcacttcct cgtatctggt cgggtgcgac ggcggcggca gtactgtgcg caagctgctg
    21301 ggcattgact tccccggcga gaagccccat atgctcgcgt tgatcgcgga cgcgcggttc
    21361 cgcgaggagc tgccccgagg ggagggaatg ggtcccatgc gcccccgcgg ggtcatgcgg
    21421 cacgacctgc gcgcctggtt ctccgccttc ccgctggaag ggggtgtctt ccgcatcacc
    21481 gtcgccttct tcgaccggcc cttcgccgac cggcgcgcgc ccatcaccga cgaggacctg
    21541 cgcgtggcgc tccgcgaggt ggccggcgac gacttcggca tgtacgacgt gcggtggcgc
    21601 tcccggctca ccgacgcttc gcggcaggcc actcggtacc gggaggggcg ggtgctgctc
    21661 gccggcgact cctgtcacat ccatctgccc gcgggtggcc aggggctcaa cctcggcttc
    21721 caggacgccg tcaacctcgg ctggaagctg ggggccaccg tcaccggcac tgcctcgccc
    21781 cacctgttgg agacctacga ggccgagcgc cgcccggtcg ccgacggcgt gctgcgcaac
    21841 acccgcgcac aggccgtcct gattgacccc gacccgcggt tccgggggct ccaggacctg
    21901 atgcgcgacc tgttgcgcca gccggagacc aaccgctatc tcgccgggct ggtctccgcg
    21961 ttggacgtgc gctacccgat cgacggcgaa caccccctgg tcgggcggcg gatgcccgac
    22021 ctcctgttgg acgccgacac ggggcgccgc cggctgagta cgcacttcca cgcggcgcat
    22081 ggcgtcctgt tgacgctctc cccggacccg caccatgccg aactcgccac cccgtggaag
    22141 gaccgagtgg acctcgtcac agccaccgat gtgctggagc gcggcccggc cgtcgagggg
    22201 ctgtccgcgg tgctcatccg ccccgacggc tatgtctgct gggcgggttc ggccgcggac
    22261 gacaccgaag ggctgacctc
//
