LOCUS       NZ_CP086322            22173 bp    DNA     linear   CON 26-NOV-2024
DEFINITION  Streptomyces halobius strain 3_2 chromosome, complete genome.
ACCESSION   NZ_CP086322
VERSION     NZ_CP086322.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces halobius
  ORGANISM  Streptomyces halobius
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9239126)
  AUTHORS   Wen,Y., Zhang,W. and Liu,X.G.
  TITLE     Streptomyces nigrumlapis sp.nov.,an antimicrobial producing
            actinobacterium isolated from Black Gobi rocks
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9239126)
  AUTHORS   Zhang,W., Liu,X.G. and Wen,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2021) Northwest Institute of Eco-Environment and
            Resources, CAS, Chinese Academy of Sciences, Donggang West Road 320,
            Lanzhou, Gansu 730000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: GS De Novo Assembler v. FEB-2021
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 241.26X
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023277745.1-RS_2024_11_26
            Annotation Date                   :: 11/26/2024 03:43:17
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,438
            CDSs (total)                      :: 8,346
            Genes (coding)                    :: 7,837
            CDSs (with protein)               :: 7,837
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 509
            CDSs (without protein)            :: 509
            Pseudo Genes (ambiguous residues) :: 0 of 509
            Pseudo Genes (frameshifted)       :: 193 of 509
            Pseudo Genes (incomplete)         :: 418 of 509
            Pseudo Genes (internal stop)      :: 17 of 509
            Pseudo Genes (multiple problems)  :: 113 of 509
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:33:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1238932
            Orig. end                         :: 1261105
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP086322.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22173
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="11"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22173
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22173
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12173](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12173)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            complement(311..448)
                     /locus_tag="K9S39_RS05965"
                     /old_locus_tag="K9S39_05995"
     CDS             complement(311..448)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS05965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_05995"
                     /product="hypothetical protein"
                     /protein_id="WP_248862312.1"
                     /transl_table=11
                     /translation="MGRFKVRKPRRDKEQRQERFRIDDRVVGEAEILDARAFLANTSAV
                     "
     gene            689..1054
                     /locus_tag="K9S39_RS05970"
                     /old_locus_tag="K9S39_06000"
     CDS             689..1054
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014151643.1"
                     /locus_tag="K9S39_RS05970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_06000"
                     /product="hypothetical protein"
                     /protein_id="WP_248862313.1"
                     /transl_table=11
                     /translation="MASQSSPTAAPSATDVLRQRYADRLPASLDDLTGPTHGRVELPLH
                     IAWSGLRTYNLDQPRQRMSYYRTALAEGQRDDLTALLNKGMLVSLWPVLRTLVSRHIRE
                     VWEAAFPALASRTSAAA"
     gene            1051..1719
                     /locus_tag="K9S39_RS05975"
                     /old_locus_tag="K9S39_06005"
                     /pseudo=""
     CDS             1051..1719
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482148.1"
                     /locus_tag="K9S39_RS05975"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_06005"
                     /product="nucleotidyl transferase AbiEii/AbiGii toxin
                     family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNLSALHRRLLADVLAIGTPYPLVITGGYAVQAHGLVNRLSQDLD
                     VATENPAPMADIARTLQQGLSQRGWHVTVISTDPLSARLVATDADGAACEVDILKENLW
                     SPPRETDYGPVLALDDVIGTKVRALADRGAVRDLIDVQAAAEHRTHPELEQLGQRHGRD
                     DFRLDDLRDRLARRRVVRRRGIHRLRPHR"
     gene            1858..>2613
                     /locus_tag="K9S39_RS05980"
                     /old_locus_tag="K9S39_06010"
                     /pseudo=""
     CDS             1858..>2613
                     /GO_function="GO:0045027 - DNA end binding [Evidence IEA]"
                     /GO_process="GO:0006303 - double-strand break repair via
                     nonhomologous end joining [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR02772.1"
                     /locus_tag="K9S39_RS05980"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_06010"
                     /product="Ku protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAQTIAKRTITWGLVTIPVTVHAATAPHPVPLHQVHTRCGGGRIR
                     LRRVCEREGVDVPYDQVARGFDAGDGRVVVLSEEDLADLPLPTSPRAIEVLAFVAADRI
                     DPLLLHKPYYLGSDPATARPYALLRDAMHESGLAAVVRVALRNRDSLALLQARGETIAM
                     QTLLWPDELRSSEDITVPRTEPPRRQELQMARTLMDTVSEDFRLEDEHDVYRAALEQVV
                     AARLEGLEPPHAPAPVEGGPIDLMAALEES"
     misc_feature    complement(2771..2791)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 21.56"
                     /tool="antismash"
     misc_feature    2813..2824
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.75"
                     /tool="antismash"
     misc_feature    complement(3011..3025)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.09"
                     /tool="antismash"
     gene            3065..3898
                     /locus_tag="K9S39_RS05985"
                     /old_locus_tag="K9S39_06015"
     CDS             3065..3898
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:TIGR02937.1"
                     /locus_tag="K9S39_RS05985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_06015"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_248862314.1"
                     /transl_table=11
                     /translation="MKRAGTGETAEDVTAAVGGDRAALERVVRAVQPEVFRLAVRFFGD
                     PRDAEDAAQEALIQVVTRLDRFRAESAFSTWVYRVATNKFLSIARTRGERQALSFTDFD
                     TELSRLPQSPLATPHPDVEEQLLIEEVKVGCTLAMLLCLDREHRMTYILGEIMELDHAT
                     AAEILGITPAAYRKRLQRARERITHLMRARCGLFDRANACRCRKRVNTAVGRGCVDPHD
                     LVFATSAQQAREFPEVLTEIRRLEHAERAGAIYRSHPEARSHVDLAGFVDGLFPA"
     gene            complement(4071..4277)
                     /locus_tag="K9S39_RS42785"
     CDS             complement(4071..4277)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS42785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_406707874.1"
                     /transl_table=11
                     /translation="MTGDEFVEPGDAGDSFGQVRGGQLAAGLVLELDVVVVFGPVVTDQ
                     QQQTLPKCVLVARRSLRKARRAA"
     gene            complement(4274..5665)
                     /locus_tag="K9S39_RS05995"
                     /old_locus_tag="K9S39_06025"
     CDS             complement(4274..5665)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033592.1"
                     /locus_tag="K9S39_RS05995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_06025"
                     /product="IS4 family transposase"
                     /protein_id="WP_406707875.1"
                     /transl_table=11
                     /translation="MPDQCATTTFTETITCAAGSFAPGHLGELTQHVPFELADAVLEET
                     RTGHRRLRHLPSRVGIYFLLALAMYPALGYARVWDKLVAGLDGLALHRPSEKALRDLRR
                     RLGPAPLKALFEAVSGPLARPATRGTCYRSWRTVVFDGCSSLKAPDQPRIRSLFSKSKH
                     RWGISGYPALRLTALVETGTRGLLGAVFGPTGVGEPTHAAELMHLLSPKMLLLADRGFD
                     GNNFYAAVARSGAQLLARLGPHRKPVVLEVLADGSYLTLLGGLRLRVIEADITVTLRNG
                     DRVHDRYRLVTTLLEPGSDPASVLVQLYHERWEIESAFYSLRHTLLRGRVLRSCDPSGL
                     EQELWAVLAFYQVLRRAMVEAAESVPGVDPDRASFTVALEAARDQLTAARGILSANDGI
                     GHSGRIGRAVLAALLPARRPRVSARKVKCPMTRYPGNPADPRPAVSQDIASVDIAVPPG
                     SSSPP"
     misc_feature    5716..5728
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     gene            5787..6083
                     /locus_tag="K9S39_RS42790"
                     /old_locus_tag="K9S39_06030"
     CDS             5787..6083
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025063.5"
                     /locus_tag="K9S39_RS42790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_06030"
                     /product="integrase core domain-containing protein"
                     /protein_id="WP_406708125.1"
                     /transl_table=11
                     /translation="MADYPERFDSLAHAREWFDAFISYYNHEHRHSGIGWHTPASVHFG
                     TAEEARDQRAVTLAAAYTRHPERFGRRPTPPEIPQQAWINDPAKRREPTPQIS"
     gene            6106..6522
                     /locus_tag="K9S39_RS06000"
                     /old_locus_tag="K9S39_06035"
     CDS             6106..6522
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS06000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_06035"
                     /product="hypothetical protein"
                     /protein_id="WP_406707876.1"
                     /transl_table=11
                     /translation="MKSSATMLTDPALTGMPRPAFEHLVTASEPYWDALAEAAFQRRFH
                     RPRSYLHPQSSSLDHYHRLLAALLRRRRAITSTFLAQLLGVGRTNLSNQFQDGHRLLDL
                     HRVVVTPLPGPPARTVEQIRARLTPDEDHRADQP"
     misc_feature    6310..6312
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(6523..6539)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.45"
                     /tool="antismash"
     gene            <6546..7448
                     /locus_tag="K9S39_RS06005"
                     /old_locus_tag="K9S39_06040"
                     /pseudo=""
     CDS             <6546..7448
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004993112.1"
                     /locus_tag="K9S39_RS06005"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_06040"
                     /product="IS701 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="GKVANCQAGVSLHLASDHASAAVDWRLFLPRTWDPASPEADPAKV
                     ARRARCGIPDDVGHVEKWQLALDMIDETRSWGLEIPLAVADGGYGDTAAFRLGLEERGL
                     HYVVGISTTVTAQPGDATPHTPPYNGTGRPPVAKYPEAARKVKQLVIDAGRVAARPVQW
                     REGSRPGTGRSGLKRMYSRFTALRIRPAGREIRRTTQGPELPVCWLLAEWPAKEAEPVQ
                     FWLSNLPADTPLTTLVRLAKIRWRIEHDYREMKQALGLAHFEGRTWNGWHHHVTLVSAA
                     HAFCTLQRLARAPKETAPA"
     gene            complement(7657..8937)
                     /locus_tag="K9S39_RS06010"
                     /old_locus_tag="K9S39_06045"
     CDS             complement(7657..8937)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612234.1"
                     /locus_tag="K9S39_RS06010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_06045"
                     /product="IS701 family transposase"
                     /protein_id="WP_248862315.1"
                     /transl_table=11
                     /translation="MDALEVNRVRAKLALFVEDVFASVPRKDQRAKGDCYLRGLMLEGR
                     RKSVQAMALRLPDGNEQNLQQFVNQSTWDPVPVQRRIAERMLPLIGPTAWVIDDVSVPK
                     DGRMSVGVAPQYCGALGKRANCQVAVSVHAATDTASCPLQWRLFLPKEWAWDTDRRART
                     RIPPEVTHREKWRLALDMLDTLATWGMTPPVVVADAAYGTNAHLRAALSDRQLAYVLAV
                     RADVTARPFDAKPVTPRRNGTVGCRPQPRYREPAPSVAALASGLGPDAFTPVTWRQGSR
                     GELRSRFAAVRVRPAGKAVERPIRAAASAEQGWWDGILPDCWLLIEWPEDSEEPTNYWL
                     SSLPAHTPIADLVRLAKVRWRIEHDYRELKHGLGLDHFEGRSWPGWHHHVTLVTAAHAF
                     LTEQRLAPKVPTPVSPSTKYSTPSRTS"
     misc_feature    complement(8086..8088)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9148..9846
                     /locus_tag="K9S39_RS06015"
                     /old_locus_tag="K9S39_06050"
     CDS             9148..9846
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS06015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_06050"
                     /product="hypothetical protein"
                     /protein_id="WP_248862316.1"
                     /transl_table=11
                     /translation="MSWNTPTGTEATAHGDAANANAGASASRSVFRRVRRIAAASLIAV
                     AALSLTACQSGEDGAKATKVSSSPDSTDMGSSSGGETVTPGENGGSDGGKQSDAGTEGS
                     TGGGSASNTGKGGAGAGSGSATGSGSAHKGKGVNGTFNGVLNYLAPGKLTVSPKSGAEQ
                     AFFVSEETKTLGAAGICASNGNVTVDDNGYGTSPCTEAQLEKAAKMNSVEVRVTLQGGI
                     ATKIVEHYHQ"
     gene            complement(10001..11152)
                     /gene="pqqE"
                     /locus_tag="K9S39_RS06020"
                     /old_locus_tag="K9S39_06055"
     CDS             complement(10001..11152)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669244.1"
                     /locus_tag="K9S39_RS06020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_06055"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_248862317.1"
                     /sec_met_domain="PF04055 (E-value: 2.3e-23, bitscore: 82.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.3e-06, bitscore: 27.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.2e-06, bitscore: 27.8,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.5e-09, bitscore:
                     36.3, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAARPATAPPRPWALLAELTHGCPLHCPYCSNPLELARKSAELT
                     TTQWTDALRQAADLGVVSAHLSGGEPLLRPDVAAIVAAADGAGIHTQLITSGVGLSRAR
                     LGRLVDAGLRSVQLSVQHADPGANDLIAGRRSFADKERAAALVRDAGLPLGLNVVLHRH
                     NLDALDDLIDLGPAWGADRIELANTQFYGWALYNRAALLPSREQLTRAQRTVQRRRAEL
                     AGRTEGRIELIWVVPDYFEGNAKPCMGGWGALSLTITPDGTTLPCPAAASIPGLDAPNV
                     RDHRLAWIWDHSRAFNRYRGTDWMRDPCRSCELRERDFGGCRCQAYALTGDATATDPAC
                     RLSPEHALVRDLVDAPSERAPGGLGHPRRPLAAPRRRPHDRTT"
     gene            complement(11149..11460)
                     /gene="pqqD"
                     /locus_tag="K9S39_RS06025"
                     /old_locus_tag="K9S39_06060"
     CDS             complement(11149..11460)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003962382.1"
                     /locus_tag="K9S39_RS06025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_06060"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_406707877.1"
                     /sec_met_domain="PqqD_RRE (E-value: 4.5e-19, bitscore:
                     66.9, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.1e-08, bitscore: 34.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGRPTAKDAAPSFKDMAPSRWCPALAPAVHLRYDRVRDTDLLLL
                     PERVVVLVGNAGTVLRLCDGQREVSDIVAELMCRYPGAPVADEVPEFLARIREEGWLR"
     aSDomain        complement(11155..11397)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_K9S39_RS06025_PqqD_RRE.1"
                     /evalue="1.50E-21"
                     /identifier="RREFam006.1"
                     /label="K9S39_RS06025"
                     /locus_tag="K9S39_RS06025"
                     /protein_end="102"
                     /protein_start="21"
                     /score="66.9"
                     /tool="antismash"
                     /translation="WCPALAPAVHLRYDRVRDTDLLLLPERVVVLVGNAGTVLRLCDGQ
                     REVSDIVAELMCRYPGAPVADEVPEFLARIREEGWL"
     gene            complement(11457..12173)
                     /gene="pqqC"
                     /locus_tag="K9S39_RS06030"
                     /old_locus_tag="K9S39_06065"
     CDS             complement(11457..12173)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056908.1"
                     /locus_tag="K9S39_RS06030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_06065"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_248868604.1"
                     /sec_met_domain="TIGR02111 (E-value: 2.8e-83, bitscore:
                     277.9, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKTSSSPRTDTSSSPPFEERLRAVARDRYHDRHPFNIRMHKGEL
                     TPWELRLWIRNRFHYQRHIPIKDALITAKLPTPELRRMWLRRIQDHDGREEGEGGIERW
                     LRLGEAAGLGRSLLMDEAGVLPGVRLAVDGYVNFCRLRSPLEAVAASLTELSAPDIMRT
                     RIDAFEKHYRWIDAEGLAYFRGRQNQGRRDSKEALALVLDWARTEEEQESAVAALAFKC
                     DVLWSLLDAVERGERT"
     gene            complement(12239..13252)
                     /locus_tag="K9S39_RS06035"
                     /old_locus_tag="K9S39_06070"
     CDS             complement(12239..13252)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003962380.1"
                     /locus_tag="K9S39_RS06035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_06070"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_248862318.1"
                     /transl_table=11
                     /translation="MLCKVLGTAAGGGVPQWNCACPGCSGARTHPEWRRRHASLAVRAE
                     DDHWYLINATPDIADQMESTPALRPGPAARRTPVAGLVLTDAELDHTLGIARLREGDRI
                     EVLATGPVRAALRDRAHLDDLLMPYATLVWRELGARPVQLCDGSDVEISAVPVSAKRPR
                     YAIGSDGFPADRSPADHVIMAGGAPQATAPGTIDPPALDPPAVDPSATEPWVVAVRLHD
                     RRTGGTVVYAPALAAWPDGFQQALADADCVLLDGTFWDDDEPCRSGFSARTATGMGHLP
                     IDGPEGTARRLAPLAARCFYTHLNNTNPLVDPDAPQHRRLAELGLAVAVEGMEISL"
     gene            complement(13263..13418)
                     /gene="pqqA"
                     /locus_tag="K9S39_RS06040"
                     /old_locus_tag="K9S39_06075"
     CDS             complement(13263..13418)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174696.1"
                     /locus_tag="K9S39_RS06040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_06075"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_248868605.1"
                     /transl_table=11
                     /translation="MQQSRQASRRPQRSRATHSPARYGEQATWRTPDYTVVETALEVTA
                     YSLSAR"
     gene            14153..14374
                     /locus_tag="K9S39_RS06045"
                     /old_locus_tag="K9S39_06080"
     CDS             14153..14374
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS06045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_06080"
                     /product="hypothetical protein"
                     /protein_id="WP_248862319.1"
                     /transl_table=11
                     /translation="MRTRSPRHVTPAMVAASALAAGLLISAAGSGGAADATHRSTSRPT
                     SHTAAGGALASEPGTPRTVSSGWSSPGA"
     gene            14398..14997
                     /locus_tag="K9S39_RS06050"
                     /old_locus_tag="K9S39_06085"
     CDS             14398..14997
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019607.5"
                     /locus_tag="K9S39_RS06050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_06085"
                     /product="sorbosone dehydrogenase family protein"
                     /protein_id="WP_248868607.1"
                     /transl_table=11
                     /translation="MLTERDSFTVHTLTQDGTKKEVGKVPNVVTTGGEGGLLSIAVSPS
                     WQTDHHVYVMHSAKEGNRIARMTFDGGELGDYKVVVDGIKKNRYHNGGRIKFGPDGYLY
                     ATTGDAQDEDLAQDTSSLNGKILRMTPDGKPAPGNPFGNLVHSYGHRNPQGITWDAQGR
                     LWDGGLGARTYDELNLIEPGKNYGWPTCEASVPRTG"
     gene            14994..15431
                     /locus_tag="K9S39_RS06055"
                     /old_locus_tag="K9S39_06090"
     CDS             14994..15431
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS06055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_06090"
                     /product="hypothetical protein"
                     /protein_id="WP_248862320.1"
                     /transl_table=11
                     /translation="MTNPKRQWPVSEASPSGVAYADGAIYMAALRGERLWRIPVDGSNT
                     GTPEAYYTNDYGRLRTVESVPGKNSLWLTTTNADNNGDGGPGSDKVFHIDLKSGPGGPV
                     LLPMARWKNSTPPTPWTGRQERDRQADKKQARPKDQGREAQ"
     gene            15428..16210
                     /locus_tag="K9S39_RS06060"
                     /old_locus_tag="K9S39_06095"
     CDS             15428..16210
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606899.1"
                     /locus_tag="K9S39_RS06060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_06095"
                     /product="alpha-ketoglutarate-dependent dioxygenase AlkB"
                     /protein_id="WP_248862321.1"
                     /transl_table=11
                     /translation="MSTPLPGFESFGQPDGCGPPDSSDRHDGKGNADEPGASGDAGTRA
                     TAPRGRRELAPGAVHVPDWLTLAQQRELVAACRGWARGPVPIRHTRLPRGGVMSVQTVC
                     IGWHWQPYAYTRTADDVNGAPVAEFPHWMVELGRRALVEAYQDPSAGEAYTPDTALINF
                     YDDQAKLGMHQDKEERSSAPVVSLSIGDSCVFRFGNTETRTKPYTDIELASGDLFVFGG
                     PSRFAYHGVPRVHPGTCDPASGLTSGRLNITMRVTGLA"
     misc_feature    complement(16463..16477)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 22.13"
                     /tool="antismash"
     gene            16478..16648
                     /locus_tag="K9S39_RS06065"
                     /old_locus_tag="K9S39_06100"
     CDS             16478..16648
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS06065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_06100"
                     /product="hypothetical protein"
                     /protein_id="WP_248862322.1"
                     /transl_table=11
                     /translation="MPARTVAPEPEVATIEPTAAIVGDGLGQPVHHVRTGELVGYLTPE
                     KFFPIDQVEKR"
     gene            17444..17599
                     /locus_tag="K9S39_RS06070"
                     /old_locus_tag="K9S39_06105"
     CDS             17444..17599
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS06070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_06105"
                     /product="hypothetical protein"
                     /protein_id="WP_248862147.1"
                     /transl_table=11
                     /translation="MTRIRLAAGALAAAALLTIFGGGVANAAPSDNYGVGHCRAGGMFG
                     DCYGVS"
     gene            complement(17867..18196)
                     /locus_tag="K9S39_RS06075"
                     /old_locus_tag="K9S39_06110"
     CDS             complement(17867..18196)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS06075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_06110"
                     /product="hypothetical protein"
                     /protein_id="WP_248862148.1"
                     /transl_table=11
                     /translation="MAANFHLDLYESALNELVSSRASEKLAAGVASKIASIARKDAPKN
                     RKGSWNMYSRSLSIDTSRSNGTVYALVQADRHPLLVEYGWRDKGGRRHPGRHILKGALV
                     KVREP"
     gene            18491..>18901
                     /locus_tag="K9S39_RS41995"
                     /pseudo=""
     CDS             18491..>18901
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024935.5"
                     /locus_tag="K9S39_RS41995"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTKRVPCPPAPGPLKAYAARFDDLFSTLAQRRGFREYLAGLLLPR
                     DRNKTLTCLAGTEPVAGAQHRAVQRLQFFLSESTWDHEKVNARRVELLLADPATATHSG
                     GVLVIDDSGDRKDGSATAHVGKQYLGSVGKIDR"
     gene            19044..19895
                     /locus_tag="K9S39_RS42000"
     CDS             19044..19895
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024935.5"
                     /locus_tag="K9S39_RS42000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transposase"
                     /protein_id="WP_283113444.1"
                     /transl_table=11
                     /translation="MARKAKESGVSLRAVAADCAYGDQDAFRGELSAAGLPFVMALKPR
                     RGAWAYGDEAYTPVDAARDLAWHGPDRPGDWTAVTRTFRDGHTTTWWAADAQLGWWGPH
                     GTTRLVVATTDPATLPAQSTWYLATNLPRPGSPRERGSCHPAADLTEVVRIYGLLHWVE
                     QSYKQVKDELGWADFQVRSDVAIRRHQTLVTCAFSFCWDTWFTPPPPVAHEAEPAPGRP
                     ERGHPTAPPAPAGLLAPRHPGRPWLADALGHAATLLAGMVNETPSHRTPVPHQRPRRRQ
                     TT"
     gene            complement(20028..21305)
                     /locus_tag="K9S39_RS06085"
                     /old_locus_tag="K9S39_06120"
     CDS             complement(20028..21305)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612234.1"
                     /locus_tag="K9S39_RS06085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_06120"
                     /product="IS701 family transposase"
                     /protein_id="WP_248862323.1"
                     /transl_table=11
                     /translation="MDVRQVQGLRAGLSAFVADVFASVPRKDQRAKGDCYLRGLMLDGR
                     RKSIQPMAERLPDGNEQNLQQFVNQSTWDPVPVRRRIAQRMVPLIGPDAWAVDDVSFPK
                     DGRMSVAVAHQYCGALGKQANCQVAVSMHAVTDTASCPLQWRLFVPEEWAADADRRHKT
                     GIPEDIGHQEKWRLALNILDELAGWGLAPPVVVADAGYGQNADFRDGLEGRGIKYVVAI
                     RSDVTVHPHDAVPTAPPWSGNGRKPQPRYRDKPPPVAALATSHGRQAFTDVTWREGSRG
                     PMRSRFLALRVRPAGVRVRRLTQSAAVAGHGSWDGVLPEVTLLVEWPEGAAAPTDYWLS
                     NLPEDTPLAELVRLAKIRWRIEHDYRELKHGLGLDHFEGRSWNGWHHHVTLVTAAHAFL
                     TEQRLSPKARTPASRSTRSWTPSRPC"
     misc_feature    complement(21267..21269)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(21387..>21602)
                     /locus_tag="K9S39_RS06090"
                     /old_locus_tag="K9S39_06125"
                     /pseudo=""
     CDS             complement(21387..>21602)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019070687.1"
                     /locus_tag="K9S39_RS06090"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_06125"
                     /product="IS630 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="ERWFALLTDKLIRRGVHTSVKALENDIRDWIDTWNENPRPFTWTK
                     TADEILKSLADYLARITPPSSPTSTN"
ORIGIN
        1 ctgcagctgg gcggtgatcc gtgcctcgcg aaggaaccgg tcgcgtgcct cgtcgccgcg
       61 gcttccgctg ccggtaagca gggagatcac cttgactgcg acgggtcgac ccagtgtctc
      121 gtcctgcgcc tcccatacgt gccccattcc gccctcgccg atctgtcgca ccaaccggta
      181 acggcccccg aggagctggt ctcgcactgt ccgcctcccc cgtttcgatc aactccgcct
      241 accgccggcg aaccggcacc ccgggatcat gacgcgaccg cgagcgcagc gcacgatacg
      301 cagtaccgtg tcaaacggca gaggtgttcg ccaagaaggc ccgagcgtcc agaatctccg
      361 cctcaccgac cacccggtcg tcgatacgga accgctcctg tcgctgctcc ttgtcgcgcc
      421 gcggcttcct caccttgaac cgtcccatcg cgggtccccc tccatatgtg gtcggcccag
      481 cctcagacag gcgacggcaa cggcacaaga gcgcctcgcg ccatcccgcc cgcctccggc
      541 gcggtaccac cgcgagtgct acgggcaccg cgtgatggcc accgcgctgg ccaggtcggt
      601 cctacgtgtg agccacctga gccgacgcga gcacagcgga tacggcccac cggtacccgc
      661 cagcacctcg gcaggggata atcgctccat ggcctcgcag tcctccccca ccgccgcacc
      721 gtccgccacg gacgtgctgc gccagcggta cgccgaccgc ctgcctgcct ccctcgacga
      781 cctcaccggc cctacccacg gccgcgtcga gctgccgctg cacatcgcct ggtccggcct
      841 gcgcacctac aacctggacc agccacgcca gcgcatgagc tactaccgca ccgcactggc
      901 cgaagggcag cgcgacgacc tgaccgcgct gctcaacaaa ggcatgctgg tctcgctgtg
      961 gccagtgctg cgcacgctgg tcagccggca catccgagag gtgtgggaag cggccttccc
     1021 cgctctggcc agcaggacct ccgcagccgc gtgaacctca gcgcactcca ccgccggctc
     1081 ctggccgacg tcctcgccat cggcaccccc taccccctgg tcatcaccgg cggctacgcc
     1141 gtacaggccc acggactggt caaccgcctc agccaggacc tcgacgtcgc caccgagaac
     1201 cccgcaccca tggccgacat cgcccgcacc ctccagcagg gcctgtccca gcgaggctgg
     1261 cacgtcacgg tgatcagcac cgacccgctc tccgcccgcc tcgtcgccac cgacgccgac
     1321 ggcgcagcct gcgaagtcga catcctcaag gaaaacctgt ggtcgccgcc acgcgaaacc
     1381 gactacggcc cggtcctcgc actcgacgac gtcatcggca ccaaggtccg agccctggcc
     1441 gaccgcggcg ccgtccgcga cctcatcgac gtccaagccg ccgccgaaca ccgaacccac
     1501 ccggaactcg aacagctcgg ccagcgccac ggacgcgacg acttccgcct cgacgacctg
     1561 cgcgaccgtc tggccaggcg ccgagtggta cgacgacgag gaattcaccg cctacggcct
     1621 caccgatgac gccatcaccg aactcagaac tgggcccagc aatgggccag cgacctcgac
     1681 gaacggctgg cacgagaaac cggcgagtac gaaaactgac ccgcccgacc ggcgcggccg
     1741 gcggctggtc ggcacccacg ccgccagctg cagcatgcgt ctgccgcccg gaccaggcgg
     1801 gggcgaggac aagtggttcg aggtgcgatc agccagtgcg ggcggtgcga tgggatcatg
     1861 gcgcagacca tcgcaaagcg gacgatcacc tggggcctgg tgaccatccc ggtgactgtg
     1921 catgccgcga ccgccccgca tcccgtcccg ctccaccagg tccacacacg gtgcggcggc
     1981 ggccggatcc ggctgcgacg cgtctgcgaa cgagagggcg tcgacgtccc ctacgaccag
     2041 gtagcccgag gcttcgacgc cggcgacggg cgcgttgtgg tgctatccga ggaggacctc
     2101 gccgaccttc cgctgccgac ttcaccccgc gctatcgagg tactcgcctt cgtggcagcg
     2161 gatcggatcg accctctgct gctgcataag ccctactacc tcggcagcga ccccgccacg
     2221 gcgcgtccgt acgccctcct tcgcgacgcc atgcacgaga gcggcctggc cgccgtcgtc
     2281 agggtggcct tgcgcaaccg tgactccctc gccctgctcc aggcgcgcgg cgagaccatc
     2341 gcgatgcaga cgcttctttg gcctgacgaa ctgcggagca gcgaggacat caccgtgccg
     2401 cgcacggagc cgccgcgtcg ccaggagctg cagatggccc gcaccctgat ggacaccgtc
     2461 agcgaggact tccgcctgga agacgagcac gacgtctacc gggccgccct cgaacaggtc
     2521 gtcgccgccc gcctcgaagg gcttgagcca ccgcacgcac ccgctccggt cgaaggcggg
     2581 cccatagacc tgatggctgc cctggaggag tccgtacggg ccgcgcggtc acgccgcggg
     2641 agcgaacaag taggcacccg ggagacggaa cagcccgact gggcccgagg tcaccggcga
     2701 ctcgctgacc ggtatgttgt cgtcgaccaa gggcgccgcg cacctcgtgg tgacgctgct
     2761 ggtccaggac cacacagccg atgctgtgca cgccggagca acaggcgcag ctggacgcga
     2821 acgcgaccgc gccgtaaagc ctgaccggca tcgcgttcag ccaccagcac ggcgtggtcc
     2881 tcgccgacct gccccatcac cggatcgtgt gccagctggg acaacggagg tcgcggcgta
     2941 cgtcctgccg tgatgcgcgc cgcctgccgg tcggccctgg ccggtcacac cgtccggggc
     3001 gggagcgtct aagtcactga aagatgtggc gggccgggca cggatgaggg agagcaggac
     3061 agtcgtgaag cgtgcgggaa caggtgagac ggccgaggac gtgacggcgg ccgtgggcgg
     3121 cgaccgggcg gctttggagc gggtggtccg tgcggtgcag ccggaagtgt tccggctggc
     3181 cgtgcggttc ttcggtgatc cccgtgatgc cgaggacgcg gcccaggagg cgctgatcca
     3241 ggtggtcacc cggctggacc ggttccgggc cgagagcgcc ttctccacct gggtgtaccg
     3301 ggtggcgacc aacaagtttc tgtccatcgc ccgtacccgg ggcgagcggc aggcactgag
     3361 cttcaccgat ttcgacaccg agctctcccg cctgccacag tcccctctgg cgacaccgca
     3421 tcctgacgtc gaggagcagc tgctgatcga ggaggtcaag gtcggctgca cgctcgcgat
     3481 gctgctctgc ctggatcgtg agcaccggat gacctacatc ctcggcgaga tcatggaact
     3541 ggaccatgcg accgcggcgg agattctcgg catcacgccg gccgcgtacc gcaagcgtct
     3601 gcagcgtgcc cgggagcgga tcacccacct gatgcgcgct cggtgcgggc tgttcgacag
     3661 ggccaacgcc tgccgctgcc ggaagcgggt gaacacggcg gtcggccgcg gctgtgtgga
     3721 cccccatgac ctcgtgttcg ccacctcggc gcagcaggcc cgggagtttc ccgaagtact
     3781 caccgagatc cgccgcctgg agcacgccga acgcgccggt gcgatctacc gatcgcaccc
     3841 ggaagcacgc tcccacgtcg acctggccgg cttcgtcgac ggcctgttcc ccgcctaatg
     3901 ggagctacgg ggccggggaa tgctcggttc cgtagccgcc agcaggtgag cactatcgcc
     3961 gccggaagca gtcgagttct ggtgtcagac cgtgcccctg ctggtggtcg ggaggccaga
     4021 ccgctgatgg ggtggcgtgc ccgccccgcg gggcgtgagc actggatcca ttaggccgcg
     4081 cgccgtgcct tccgcaggct acgacgcgca acgagaacac acttggggag ggtttgttgc
     4141 tgctgatcgg tgacgactgg gccgaagacc accacgacgt cgagctccag gacgaggccg
     4201 gccgcaagct ggccaccgcg aacctgcccg aaggagtcgc cggcatcgcc aggctccacg
     4261 aactcatcgc ccgtcacggc ggtgagctgg atcctggggg aaccgcgatg tccacggaag
     4321 cgatgtcctg gctgacagcg gggcgggggt cggccgggtt gccggggtag cgcgtcatag
     4381 ggcacttcac ctttcgggcg ctgacgcgcg ggcgccgggc cggaagcagg gctgcgagta
     4441 cagctcggcc gatccggccg gagtgcccga tgccgtcgtt cgcggacaga atgcctcgcg
     4501 ccgcggtgag ctggtcccgc gccgcttcga gagccacggt gaagctcgcg cggtcggggt
     4561 cgacgcccgg gacggactcg gccgcctcga ccatggccct gcggagaacc tggtagaacg
     4621 ccaggaccgc ccacagttcc tgctccagcc cggaggggtc gcaagaacgc aggacccgcc
     4681 cgcgcagaag cgtgtgccgc aacgagtaga aggccgattc gatctcccac cgctcatggt
     4741 agagctgcac gagtacggac gcggggtcgc tgccgggttc gaggagtgtg gtgaccagac
     4801 ggtaacggtc gtgcacgcga tcgccgttgc gcaaggtcac ggtgatgtcc gcctcgatga
     4861 cccggagcct gagcccgccc agcagggtga gataggagcc gtcggcgagg acctccagga
     4921 cgacgggctt gcggtgcggg ccaagacggg ccagcagctg agcgccgctg cgggcgacgg
     4981 ccgcgtagaa attgttcccg tcaaagcccc ggtcggccag caggagcatc ttcggcgaca
     5041 agagatgcat gagctcggcg gcatgagtcg gctcaccgac accggtgggg ccgaagaccg
     5101 ccccgagcag gccccgcgta ccggtctcga ccagggccgt caaccgcagg gccggataac
     5161 ccgaaatgcc ccaccgatgc ttggacttac tgaacagact tcgaatccgt ggctggtcag
     5221 gggccttgag cgagctgcag ccgtcgaaaa cgaccgtgcg ccaggaacgg taacaggtgc
     5281 ccctcgtggc cggtcgggcg agcggtccgg acaccgcctc gaacagcgcc ttcaagggtg
     5341 ccggccccag acggcggcgc agatcacgca gtgccttctc cgacggccgg tgcagagcca
     5401 gcccgtcgag gccggcgacg agcttgtccc atacgcgtgc gtatcccagc gccggataca
     5461 tcgccagggc caacaggaag tagatgccga cccgtgacgg gagatgccgc agacgacgat
     5521 ggcccgtacg ggtctcctcc aagacggcgt cggccagctc gaacggcaca tgctgggtca
     5581 gctcgccaag gtgtccgggc gcgaaggaac cagccgcgca ggtgatggtt tcggtgaacg
     5641 tggtggtggc acactgatcg ggcaacggga cctctcgggc aggaagacct tggacggctt
     5701 ctctgcctaa cgaaggtccc gttgtcacgt ccgcagcctc accagccgcc gatttgacga
     5761 tgccgcatct cgcttaacta cgcggcattg ccgactaccc cgaacgattc gactccctgg
     5821 cccacgcccg cgaatggttc gacgccttca tctcctacta caaccacgaa caccggcact
     5881 cgggcatcgg atggcacacg ccagccagcg tccacttcgg caccgccgag gaggcccgcg
     5941 accaaagagc cgtcaccctg gccgcggcat acacccgcca ccccgaacgc ttcggccgcc
     6001 gccccacacc acccgaaata ccccagcagg cgtggatcaa cgaccccgcc aaacgcaggg
     6061 aacccacacc acagatctca tagcatcaca aacgtctcac tggacttgaa atcttccgcc
     6121 acgatgctca ccgatccggc cctgaccggc atgccacggc ccgccttcga acacctcgtc
     6181 acagcctcgg agccgtactg ggatgccctg gccgaggcgg ccttccaacg gcgcttccac
     6241 cgcccgcgca gctacctcca cccgcaatcc agcagcctgg accactacca ccgcctcctg
     6301 gcagccctct tacgccgccg ccgagcgatc accagcacct tcctggccca actgctggga
     6361 gtcggccgca ccaacctgtc caaccagttc caggacggcc accgactcct ggacctgcac
     6421 cgcgtagtcg tcacaccgct ccccggacca cccgcccgca ccgtggaaca gatccgagcc
     6481 cgcttgactc ccgacgaaga ccaccgagca gaccaaccct gacagttatt cagatacaag
     6541 tcccgggcaa ggtcgccaac tgccaggcag gcgtgtcact tcatctcgcc tctgaccatg
     6601 cctcggccgc ggtcgactgg cgcctgttcc tgccgcggac gtgggaccca gcctcgccgg
     6661 aggccgatcc cgccaaggtc gcccggcgcg cgcggtgcgg catccccgat gacgtcgggc
     6721 atgtcgagaa gtggcagctc gccctggaca tgatcgacga gacacggtcc tggggcctgg
     6781 aaatccccct cgccgtcgcg gacggcggat acggggacac cgccgccttc cggctcgggc
     6841 ttgaggaacg cggcctgcac tacgtggtgg gtatctccac cacggttact gcccagccgg
     6901 gcgatgcaac accgcacact ccgccctaca acgggaccgg acgcccaccg gtggcgaagt
     6961 atcccgaggc agccaggaag gtgaaacagc tggtcatcga cgccggacgt gtggcggcca
     7021 gacctgtcca gtggcgtgag ggatcccggc ccggcaccgg ccgaagcggc ctcaaacgca
     7081 tgtactcccg gttcacggct ctgcgaatcc ggcccgccgg acgcgagatc cgccgcacca
     7141 cacaggggcc cgagctgccc gtgtgctggc tgctggccga atggcccgcg aaggaggccg
     7201 agccggtcca gttctggctc tcgaacctgc ccgccgacac cccgctgacc acactcgtgc
     7261 ggctggcgaa gatcagatgg cggatcgagc acgactaccg ggagatgaaa caggccctgg
     7321 ggcttgccca cttcgaaggc cgcacctgga acggctggca ccaccacgtc accctcgtct
     7381 ccgccgccca cgccttctgc accctccagc gactggccag agccccaaaa gaaacggcgc
     7441 cggcctgagc ctctaccagg tagtccgcga gttacagacg ctcctcgcgg tctgggccgg
     7501 cgcctgcccc acctgtcacc gcgacatact cacagccaca ccaacctgac caagccctac
     7561 tagtaggact ccgttaggtc tgtctcgatc ttggtgtcat gtgtgtcctg gtgggcaggc
     7621 gttgttggca ggtggtgcag atgccggtcc agcacctcaa gacgtcctgg agggcgtcga
     7681 gtacttggta gagggtgaga ccggcgtggg cacttttggg gccaggcgct gttcggtgag
     7741 gaaggcgtgg gcggcggtga cgagggtgac gtggtggtgc cagccgggcc aggaacggcc
     7801 ttcgaagtgg tccaggccca ggccgtgctt gagttcgcgg tagtcgtgct cgatgcgcca
     7861 gcggaccttg gccaggcgga ccaggtcagc gatgggtgtg tgcgccggta ggctggacag
     7921 ccagtaattt gtgggttcct cgctgtcttc gggccattcg atcagcagcc agcagtcggg
     7981 caggattccg tcccaccagc cctgttcggc tgaggcggcg gctcggatgg ggcgttcgac
     8041 tgccttgccg gccgggcgta cacgcacggc ggcgaagcgg gaacgtaact cccctcgcga
     8101 gccttgccgc cacgtcacgg gggtgaaggc atccggccca aggcctgagg cgagagctgc
     8161 cacggacggt gcgggttccc ggtatcgggg ctggggccgg cagccgacgg tcccgttgcg
     8221 gcgtggggtc acgggtttcg cgtcgaaggg gcgggcggtc acatcagcgc ggacggccag
     8281 cacgtaggcg agttggcggt cggacagagc cgcccgcagg tgcgcgttgg tgccgtaggc
     8341 ggcgtcggcc accacgactg gtggtgtcat gccccaggtg gcgagcgtgt cgagcatgtc
     8401 cagagccagg cgccatttct cgcggtgtgt gacctcgggc gggatgcggg tcctggcccg
     8461 ccgatcggtg tcccaagccc actccttggg caggaacagg cgccattgca gcgggcagga
     8521 ggcggtgtcg gttgcggcat ggacgctgac cgcgacctgg cagttcgccc gtttccccaa
     8581 cgctccgcag tactgcggag ccaccccgac cgacatccgg ccgtccttgg gcaccgacac
     8641 gtcgtcgatc acccaggcgg tcgggccgat cagtggcagc atccgctcgg cgatccgccg
     8701 ctgcaccggc acgggatccc acgtggactg gttcacgaac tgctgcaggt tctgctcgtt
     8761 gccgtccggc agccgcaaag ccatggcctg gacggacttg cggcgaccct ccagcatcag
     8821 accccgcaga tagcagtcgc ccttggcccg ctggtccttg cgcggtactg aggcgaacac
     8881 atcctccacg aacaacgcca acttcgcccg aacccggttc acttcaagtg catccacaca
     8941 cccaacatgc tcctgatcta gcacaacagg aagacctaac ggagtcctac taggggctgt
     9001 ccggtgaatc acccacgacc caccggacag cccctagtgg atcaccgcgg tcccggccag
     9061 gctgatgcat gtggcgctca cggagatgag tgccacgaac gccacactca gaaccgctgt
     9121 gcagcagcgg gcatacgagg ggatcccatg tcctggaaca cgcccaccgg caccgaagcc
     9181 accgcccatg gcgatgccgc caacgccaac gccggtgcct ccgcgtcccg ttccgtcttc
     9241 cggcgtgtgc gccggatcgc cgcggcttcg ctgatcgccg tcgccgcgct ctcgctcacc
     9301 gcctgtcaga gcggtgagga cggcgccaag gcgaccaagg tctcgtcgag cccggactcc
     9361 acggacatgg gctcgtcgtc cggcggtgag acggtgacgc cgggcgagaa cgggggctcg
     9421 gacggcggca agcagtcgga cgccggtacg gagggcagca cgggcggcgg ctcggcatcg
     9481 aacaccggga agggcggcgc cggtgcggga tccggctcgg cgaccggttc cggttccgca
     9541 cacaaaggga agggcgtgaa cggcacgttc aacggcgtcc tcaactacct ggcgcccggc
     9601 aagctgacgg tgtccccgaa gtccggggcc gagcaggcgt tcttcgtcag tgaggagacg
     9661 aaaaccctgg gtgccgccgg aatctgcgcg tccaacggca atgtcacggt ggacgacaac
     9721 ggctacggaa cctcaccgtg caccgaggca cagctggaga aggcggccaa gatgaactcc
     9781 gtcgaggtcc gcgtcaccct ccagggcggc atcgccacga agatcgtgga gcactaccac
     9841 cagtgaccgt tcggagcgtt cgctccgccg agcaccgctc accgagccgc tcacggctcg
     9901 cacccgagca gccgccgtcg cggacttccc cggccgcgac ggcagcccca tacctaccgc
     9961 cgtgctccct cagcccacgt actcgaccag ggattccgtg tcaggttgtt cggtcatgcg
    10021 gtcgccgcct cggtgcggcg agtggcctgc gagggtgtcc gagtcccccc ggcgcccgtt
    10081 cggacggggc gtccaccagg tcgcgtacga gggcgtgctc cggggacagc cggcaggccg
    10141 ggtcggtggc cgtggcatcg ccggtgagcg cgtacgcctg gcagcggcag ccgccgaagt
    10201 ccctctcacg cagctcacag ctgcggcacg gatcgcgcat ccagtccgtg ccccggtagc
    10261 ggttgaaggc ccgggagtgg tcccagatcc atgccagccg atggtcacgg acattgggcg
    10321 catcgaggcc gggaatcgag gcggccgccg ggcaggggag ggtcgtgcca tcgggagtga
    10381 tggtgagcga gagggcgccc caaccgccca tacagggctt ggcgttgccc tcgaagtagt
    10441 cggggacgac ccagatcaac tcgatccgtc cctcggtccg gccggcgagc tcggcgcgtc
    10501 gtcgctgtac ggtccgctgc gcgcgggtga gctgttcgcg ggacggcagc agggcggcgc
    10561 ggttgtacag tgcccacccg tagaactggg tgttggcgag ttcgatgcgg tccgcgcccc
    10621 aggccggtcc gagatcgatg aggtcgtcca gcgcgtcgag gttgtggcgg tgcagtacga
    10681 cgttgagtcc gagcggcagc ccggcatccc gtaccagggc ggcggcccgc tccttgtcgg
    10741 cgaaggagcg gcgcccggcg atcaggtcgt tggcgcccgg gtcggcgtgc tggacggaca
    10801 gctgcacact gcgcagaccg gcgtcgacga gccggccgag ccgggcccgg ctgagaccga
    10861 cgccgctggt gatgagctgg gtgtggatgc ctgcgccgtc ggcggccgcg acgatcgccg
    10921 ccacgtcggg gcgaaggagg ggttcaccgc cggagagatg cgcgctgacc acccctaggt
    10981 cggcggcctg acgcagtgcg tccgtccact gggtggtcgt caactccgct gatttgcggg
    11041 ccagttcgag cgggttggag cagtaggggc agtgcagtgg gcagccgtgg gtgagttcgg
    11101 cgaggagggc ccaggggcgg ggtggtgcgg tggccggccg ggccgccgtc atcgcagcca
    11161 gccttcctcc cggatccggg cgaggaattc cggcacctcg tccgccaccg gcgcacccgg
    11221 ataccggcac atcaactccg cgacgatgtc cgatacttcg cgctgcccgt cacacagacg
    11281 cagcacggtg ccggcattgc ccacgagcac cacgacacgt tccggcagaa gcagcaggtc
    11341 ggtgtcgcgc acccggtcgt agcgcaggtg gacggcgggg gcgagggcgg ggcaccagcg
    11401 cgatggagcc atgtccttga aggagggagc cgcgtccttg gcggtcggcc tgccgttcac
    11461 gtccgctccc ctcgctcgac cgcgtccagc agggaccaca gcacatcgca cttgaaggcg
    11521 agcgcggcga ccgccgattc ctgctcctcc tcggtgcgcg cccagtccag gaccagcgcg
    11581 agcgcctcct tgctgtcccg ccggccctgg ttctgccgac cacggaagta ggcgaggccc
    11641 tcggcgtcga tccagcggta gtgcttttcg aacgcgtcga tccgggtgcg catgatgtcg
    11701 ggtgcggaca gttcggtgag cgaggcggcg accgcctcca gaggcgagcg cagccggcag
    11761 aagttgacat agccgtcgac ggcgagccgt acaccgggca gcacgcccgc ctcgtccatc
    11821 agcagcgacc ggccgagtcc ggccgcctcg ccgagccgca gccagcgctc gatgccgccc
    11881 tcgccctcct cccgcccgtc gtggtcctgg atccggcgca gccacatccg gcgcagctcc
    11941 ggcgtgggca gcttcgcggt gatcagggcg tccttgatgg ggatatggcg ctggtagtgg
    12001 aaccggttac ggatccagag gcgcagttcc catggggtca actctccctt gtgcatacgg
    12061 atgttgaagg ggtggcggtc gtggtagcgg tcgcgcgcca cggcccgcag ccgctcctcg
    12121 aacggtgggc ttgacgaggt atccgtccgc gggcttgacg aggttttcgt cagctggttc
    12181 gaagtggttt tcgtccgcgg gcttgaagag gtatgcgtca gctgactcga tcgcctgctc
    12241 atagggaaat ctccatccct tccacggcca ccgccagacc cagttcggcc agtcgcctgt
    12301 gctgcggcgc gtcgggatcg acgagggggt tggtgttgtt gaggtgggtg tagaagcagc
    12361 gggcggcgag cggggcgagt cgccgggcgg tgccttcggg cccgtcgatg ggcagatggc
    12421 ccatgcccgt ggccgtacgg gcggagaatc cgctgcggca tggttcgtcg tcgtcccaga
    12481 aggtgccgtc gagcaggaca cagtcggcat cggccagcgc ttgctggaag ccgtcgggcc
    12541 aggcggcaag cgcgggcgcg tagacgacgg tgcctccggt acggcggtcg tgcagccgta
    12601 ccgcgacgac ccatggttcg gtggccgatg ggtcgaccgc cggtgggtcg agcgccggtg
    12661 ggtcgatggt ccccggggcg gtggcctgcg gggcaccacc cgccatgatg acgtgatcag
    12721 ccgggctacg gtcggccggg aaaccatcgc tgccgatcgc gtagcggggc cgtttcgcgg
    12781 aaacgggcac ggcgctgatc tcgacgtccg acccgtcaca cagctgcacc ggccgtgccc
    12841 ccaactcccg ccatacaagc gtggcgtacg gcatgaggag gtcgtccagg tgcgcccggt
    12901 cgcgcaatgc ggcgcggacc ggtccggtgg cgagcacctc gatgcggtcg ccctcacgga
    12961 gccgtgcgat gccgagggtg tggtcgagtt cggcgtccgt gagcaccagt cccgccaccg
    13021 gtgtacgccg tgccgctggg cccggacgca gggcgggggt gctttccatc tggtcggcga
    13081 tatcaggggt ggcgttgatc agataccagt ggtcgtcctc ggctcgtacg gcgagcgagg
    13141 cgtggcgccg acgccattcg gggtgtgtgc gtgccccgga gcacccgggg cacgcacagt
    13201 tccattgggg cactccgcca ccagccgcgg tgccgagcac cttgcacagc atggcgggcc
    13261 ggtcagcgtg cggacaggga gtacgcggtg acctccagtg cggtctcgac caccgtgtag
    13321 tccggagtgc gccaggtcgc ctgctcgcca taccgggccg gggagtgggt ggcgcgcgag
    13381 cgctgagggc gccggctggc ctgccggctc tgctgcatgc cgtcgtgcac accgttcacg
    13441 gcgttgatgt agttcacggc gttgatgtcg gtgatgttgt tcatatcgct catctagggg
    13501 tccagccctt ctcgtgggtg ctgtggccgt ggcagtgcct gactgtgccg gtacctgact
    13561 gtggcaatgc ctggctgtgg cagtaggtct ctggatcggc gctgggtggt tacggtcctg
    13621 tcgtcacggc tttggccgcg cttgcacggt gcacgtctgg cattcgtctg acggacatga
    13681 ctcgcacacc ggccgccgca tcactcgaat gccgtcgacg cccccacccc ggccatcgct
    13741 caatcgaccg tcatggagac atcgacggcg acaccgacgc cgacggacgc atgaccggcc
    13801 gtcgttcgtc gctgcactgc ggagggagcg cctcttaccc gtgcgagcgc gttccggtcg
    13861 cgtcgccgag ccgtcaacgt tcccagttgg cggcggccgt tggcggatca ttgagcaggg
    13921 tgccgctttg cagaatcctc agccacggcg tcacggtcaa tgggcagagc gaaattcatc
    13981 aactccccct gctccaaagg gaaatccccc cgcgatccct tgaccccatc ccacaggcgc
    14041 agtaccttcc cgccgaacca acaggaaact ttcctgtcag cccggcgccg ctgatgctca
    14101 cgagggagtg ccatgccccg tcacgccgcc tgaccggagg acccccatgc gcatgcgcac
    14161 cagatcccca cgccacgtca cgccggccat ggtggccgca tccgccctcg ccgccggcct
    14221 gctcatatcg gccgccgggt ccggcggcgc cgccgacgcg acacaccgca gcacatcccg
    14281 ccccacatcc cacaccgcag cgggcggcgc cctcgcctcc gaacccggca caccccgcac
    14341 cgtctcgtcg ggctggtcat cccctggggc ctgagctggc tgccggacgg ctcggccctg
    14401 ctcaccgaac gcgactcgtt caccgtccac accctcacgc aggacggtac gaagaaagaa
    14461 gtcggcaagg tacccaacgt cgtcaccacg ggcggcgagg gcggactgct gagcatcgcc
    14521 gtatcgccgt cctggcagac cgaccaccat gtgtacgtga tgcactccgc caaggaaggc
    14581 aatcggatcg cacggatgac gttcgacggc ggcgaactcg gcgactacaa agtcgtggtc
    14641 gacggcatca agaagaacag gtaccacaac ggcggacgca tcaaattcgg ccccgacggc
    14701 tacctctacg ccacgacggg cgacgcccag gacgaggacc tggcccagga caccagctcg
    14761 ctcaacggca agatcctccg catgaccccc gacggcaagc cggcccccgg caaccctttc
    14821 ggcaacctgg tccactccta cggtcaccgc aatccgcagg gcatcacctg ggacgcccaa
    14881 ggacgcctgt gggatggggg gttgggtgcc agaacgtacg acgagctgaa cctcatcgag
    14941 cccggcaaga actacggctg gcccacgtgc gaggcgagtg ttccacggac gggatgacca
    15001 atcccaagcg ccagtggccg gtcagtgaag cctcacccag cggggtggcc tacgccgacg
    15061 gtgcgatcta catggccgcg ctccgcggcg aacgcctgtg gcgcattccc gtcgacggct
    15121 cgaacacggg cacccctgag gcgtactaca ccaacgacta cgggcgactg cgtacggtcg
    15181 agtccgtacc cggcaagaac tcgctgtggc tgaccaccac caacgcggac aacaacggcg
    15241 acgggggacc cggttcggac aaggtgttcc acatcgatct caagtcaggc cctggcggcc
    15301 cagtcctcct ccccatggca cgctggaaga acagcactcc accgaccccc tggaccggca
    15361 gacaagaacg ggaccggcag gcagacaaga agcaggcaag accgaaagac caaggtcgag
    15421 aagcgcaatg agcacgccac tccccggctt cgagagcttc gggcagcccg acggatgcgg
    15481 gccgcctgac agctccgacc ggcacgacgg caaagggaac gccgacgagc ctggggcctc
    15541 cggcgacgcc gggacccgcg ccacagcgcc ccgcggccgc cgggaactcg ctcccggcgc
    15601 cgtccacgtc cccgactggc tcaccctggc acagcagcgc gaactggtcg cggcctgtcg
    15661 cggctgggca cgcggcccgg tcccgatccg gcacaccagg ctcccccggg gcggtgtgat
    15721 gtccgtccag acggtgtgca tcggatggca ctggcagccg tacgcgtaca cccgcaccgc
    15781 cgacgacgtc aacggtgccc cggtcgccga attccctcac tggatggtcg agttgggccg
    15841 cagagcactg gtcgaggcat atcaggaccc gtccgcgggc gaggcctaca caccggacac
    15901 cgcgctgatc aatttctacg acgaccaggc caagctcggc atgcaccagg acaaggagga
    15961 gcggtccagc gcgccggtgg tctccctcag catcggcgac agctgcgtct tccggttcgg
    16021 caatacggag acccgcacca aaccgtacac cgacatcgag ctggcgtccg gcgatctctt
    16081 cgtcttcggc ggaccgtccc ggttcgcgta tcacggggtg cccagggtcc acccgggcac
    16141 ctgcgacccc gcgtccggcc tgaccagcgg gcgcctcaac atcacgatgc gggtcaccgg
    16201 cctcgcctga agcgcaaccg acgccggttc tgtcgcgaag gcggaggaac cctcgggctg
    16261 gcagaacacc gagctgcgcc atgtccccgg gattcgtgcg agcaatcacg aggcggcgtt
    16321 ccacttcggc gggaagggag gtaagcgcag caaggagcca gccgagcccg tcgtactcgc
    16381 cggcattacc tacaccggcg acggccggta cgagatatgg aatcaagaca cgcgtgacgt
    16441 gctgatgacg tgctcgctcc agacccacat ctggtggatg cctgcaagga cggtggcgcc
    16501 ggagcccgag gtcgcgacca tcgagccgac ggcggctatc gtgggcgatg gcctcggtca
    16561 gccggtgcat cacgtgcgga ccggggagtt ggtcggctac ctcacccccg agaagttctt
    16621 cccgattgac caagtggaga agcgttgaat aacgagctgg catgcctgga tgcccggcac
    16681 agtggatgtg ccggggaggt gctgtaccgc gagagcctga gcggcaccgg taccgcgatc
    16741 cccaggtgcg accagcacca ggccctcgcg gaggcacgcg ccgagaatgg ccgtcgaatc
    16801 caacccggct gagcagctcg taagcctctc gatgaactca tcgagatcct tcgggacgcc
    16861 cctaagactg gaggagggcc gaagtgggat gagcggaacg ccctcgacat cagcaatagc
    16921 taccgcaaga acatcattca gaagggtccc cgattcggag acgttgcgct ttaaacgcag
    16981 aaaggcgctc tccccggcca tacggccggg gagagcgctg aatggtgctg ggcatgccgc
    17041 tgaagcgccc cgattcgttc ggggcgaggt ccgccgttcg gcctactttg agcatcgcgc
    17101 ggcagtaccg ctctatccgg acgccggact gcggtgagga ctggccccat gggcccggca
    17161 cacccctggt cgccctcggg accgggctca acagcaccag gccccctaga tggcatacac
    17221 caggtggtat ctgccgcacg ccgatggatc atggaggtac ggcttctctc cagccgcccg
    17281 cggcctgaga tggggttccg cccaagctca cgggacggac gagagcaaca ggcacgcagc
    17341 atggctcgga gcgtcctccg tgacgtcccg gcaaggaacg cctggacgtc acggcagacc
    17401 gaagcctgat tcaccaccga aacagcccaa aggaaggaac accgtgacac gtatcagact
    17461 ggccgccgga gcccttgccg ccgcagcgct gctgacaatc ttcggcggag gcgtcgccaa
    17521 cgccgcaccc tcagacaact acggcgttgg ccactgcagg gcggggggga tgttcggaga
    17581 ctgctacggc gtctcgtgat ctgcccggca ggcatgtagc caagccgctt gtggtcgtct
    17641 tcacttacca gtcttggcag gtgaagacgg ccgcaccggg gcgggaacga cccggcgagg
    17701 gccatgagca tctgctgacg ctccgccacc gctgaaacat caaacgcgac tggcggacgg
    17761 cacgccgtgt cggccggctc gcggccgacc aagtctccgg tcaccgtgtg cgctagttcg
    17821 ggcttggcgc gcaggtattc atggacgacg gagaccggat cgaccctcac ggttcccgga
    17881 ccttcaccag ggcgcccttg aggatgtggc ggcccggatg gcgccggccg cccttgtcac
    17941 gccagccata ctccaccagt agcgggtggc ggtcggcctg gacgagcgcg tagacggtgc
    18001 cgttgctgcg ggaggtgtcg atcgacaggg agcgggagta catgttccag gagcccttgc
    18061 gattcttggg cgcgtccttg cgggcgatgg acgcgatctt cgatgccacc cctgcggcca
    18121 gcttttccga agcccgggag gagaccagct cgttgagggc agattcgtag aggtcgaggt
    18181 ggaagttcgc tgccatcagt gctcgaccct ccacgcccgg acccggacgt gccgtaggga
    18241 cccctgcccc catctcatcg gcacgccgtc cacctcgtac gtctggccat tccacgcgat
    18301 acggtccgcg gattcgacgc gagcgcccca gggcaggtag gccaccaagc gctcctgtgc
    18361 ggtctctcgt tcgggactgc ggacctcgaa ggaacggtcc ggttggacac tagcggtggt
    18421 ttgttgacgg cggttcgggt cggtagtagg ccagttggtg ggaactccgc tcgctgtccc
    18481 gggggttgtg atgaccaagc gtgtgccgtg tccgcccgcg ccggggccgt tgaaagccta
    18541 tgccgcccgc ttcgatgacc tgttttccac gttggcacag cgccgggggt tccgcgagta
    18601 cctcgctgga ctgctgctgc cgagggaccg gaacaagacg ctgacctgcc tggccggtac
    18661 ggagccggtg gccggtgccc agcaccgggc ggtccagcgg ctgcagttct tcctgtccga
    18721 gtcgacctgg gaccacgaga aggtcaacgc ccgccgtgtg gaactgctgc tggccgatcc
    18781 agccacggcc acgcactcgg gcggggtgct ggtcatcgac gactccggcg accgcaagga
    18841 cgggagtgcg accgcacacg tcggcaagca gtacctgggc tcggtcggga aaatcgaccg
    18901 cggcgtcgtc accgtgacca cctgctgggc ggacgaacgc gtctactacc ccctgcacgc
    18961 cgtgccctac acccccgccc accacttccc gaaggggaag aacgaccccg acttcccgca
    19021 cgaaactcca gatcggagcc gacctggccc ggaaggcgaa ggagtcgggg gtgtctttgc
    19081 gggcggtggc cgccgactgt gcctacggcg accaggacgc cttccgcggg gaactgtcgg
    19141 ccgcagggct gccgttcgtg atggcgctca aaccccggcg gggagcctgg gcctacggcg
    19201 acgaggcgta cacgcccgtc gacgccgccc gcgacctggc ctggcacgga ccggaccgcc
    19261 ccggcgactg gacggcggtg acccgcacct tccgcgacgg gcacaccact acgtggtggg
    19321 ccgccgacgc gcagctgggc tggtggggtc cgcacggcac cacccggctg gtggtggcca
    19381 cgaccgatcc ggccacgctg cccgcgcagt ccacctggta cctggccacc aacctgcccc
    19441 ggccaggatc gccacgcgag aggggcagct gtcacccggc cgccgatctc accgaagtcg
    19501 tgcggatcta cggactgctg cactgggtcg agcagagcta caagcaggtc aaggacgagc
    19561 tcggatgggc tgacttccag gtccgctccg atgtcgccat ccgccgccac cagaccctcg
    19621 tcacctgcgc gttcagcttc tgctgggaca cctggttcac cccgccccca cccgtcgccc
    19681 atgaggcgga gccggctcct ggccggccag agagggggca ccccaccgcc ccaccagccc
    19741 cagccggcct gctggcccca cgccatccgg gccgtccgtg gctggctgac gccctgggcc
    19801 acgctgcaac gctactggcg ggcatggtca acgaaacccc ctcccaccgc actccagtcc
    19861 ctcatcaacg ccctcggcgc aggcagacca cttgatctct accgcccggt ctaacaaacc
    19921 accgctagta gggctccgtt aggtcggtgt gggtcttggc gggcggcgtc tgcctgatcg
    19981 tctgggcagg gggcggtggc aggtggtgca ggtgccggtc cagcagttca gcagggtctg
    20041 gagggcgtcc aggacctggt agagcgtgag gccggtgtgc gggcttttgg ggagagccgc
    20101 tgttcggtga ggaaggcgtg ggcggcggtg accagggtga cgtggtggtg ccagccgttc
    20161 caggaacgtc cctcgaagtg gtccaggccc aggccgtgct tgagttcccg gtagtcgtgc
    20221 tcgatgcgcc agcggatctt agccaggcgg accagttcgg cgagcggggt gtcctcgggc
    20281 aggttggaca gccagtagtc ggtcggcgct gcggcgcctt cgggccactc gaccagcaag
    20341 gtgacctcgg gcaggacacc gtcccaagag ccgtgcccgg cgacggcggc ggactgggtc
    20401 agacgacgga cccgcactcc ggccggccgg acccgcaggg ccaggaagcg tgaacgcatt
    20461 ggtccgcgtg agccttcacg ccaggtaacg tcggtgaaag cctgccgtcc atggctggtg
    20521 gcgagtgcgg ctactggggg cggcttgtcg cggtagcggg gctgcggttt gcggccgttg
    20581 ccggaccacg gcggtgcggt gggcaccgca tcgtgcgggt ggacggtcac atccgagcgg
    20641 atggcgacga cgtacttgat gccgcggccc tccaggccgt cgcggaagtc ggcgttttgg
    20701 ccgtagccgg cgtcggccac caccaccggc ggcgccaggc cccacccggc cagctcgtcc
    20761 aggatgttca gggccaggcg ccacttctcc tggtgcccga tgtcctcggg gatccccgtc
    20821 ttgtgccgcc ggtcggcgtc tgcggcccac tcttcgggca cgaacaggcg ccactgcagc
    20881 gggcacgacg cggtgtcggt gactgcgtgc atgctcaccg cgacctggca gttggcctgc
    20941 ttgcccagtg caccgcagta ctggtgggcg accgccaccg acatccggcc gtccttgggg
    21001 aacgacacgt catcgactgc ccaggcatcc gggccgatca gcggcaccat ccgctgcgcg
    21061 atccgtcgcc gcaccggcac cggatcccag gtggactggt tcacgaactg ctgcaggttc
    21121 tgctcgttgc cgtccggcag ccgctcagcc atcggctgga tcgacttgcg ccgcccgtcc
    21181 agcatcaatc cccgcagata gcagtccccc ttcgcccgct gatccttccg cggcaccgat
    21241 gcgaacacat ccgccacaaa cgctgataac cccgcccgca aaccctgaac ctgccgcacg
    21301 tccatccgac caacatgctc cccccgaact tgatcgggaa gacctaacgg agccctacta
    21361 gtgtgatgcg ccagaaattc tgagtgttag ttggtgctgg ttgggctgct gggtggggtg
    21421 atcctggcga ggtagtcggc gagggacttg aggatctcgt cggcggtctt ggtccaggtg
    21481 aagggtctgg ggttctcgtt ccaggtgtcg atccagtcac ggatgtcgtt ctcgagggcc
    21541 ttaacggagg tgtggacgcc acggcggatg agtttgtccg tcagcagggc gaaccaccgc
    21601 tcgtcgggta ggaccgctgc attgctgcag cggtcccccc tcagaaccgg ccgtgctcga
    21661 tctccgagca accggctcaa gcaagcccct tgggctcgcg ggcggacaga agcgctggtc
    21721 tccggcttgt gccggtggcc agccgtcgat ggcagtgggt gtggatcagg cgtggggcgg
    21781 cggttttgtc cggcttgccg ttgcccgcgt cggcggtgat cgcgtgtttg cggatcgccg
    21841 tgcgggtgac cttgagccac tgttcccact gttcggggct ttgcggctcg tggtcggcgt
    21901 gcagcagcag ccctccgcag agtgggcaac ggccgtcctg cttctgcaac agatgcaagg
    21961 tgcctttgcc cagcgggagt ttgccgcggc ggcgccgctt ggcccagaag tcggccaggg
    22021 cgggatcgtc ggttgacgcc ctccccggca ccatccggtg ccggacgatc ggcgtccagg
    22081 cgaacttgta gaggtagaaa ccgctggtgc ggtccccgaa cacccacgcg tcctgcctga
    22141 acgggttgaa catgccgaag taccgggcgg tca
//
