LOCUS       NZ_CP086322            21080 bp    DNA     linear   CON 26-NOV-2024
DEFINITION  Streptomyces halobius strain 3_2 chromosome, complete genome.
ACCESSION   NZ_CP086322
VERSION     NZ_CP086322.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces halobius
  ORGANISM  Streptomyces halobius
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9239126)
  AUTHORS   Wen,Y., Zhang,W. and Liu,X.G.
  TITLE     Streptomyces nigrumlapis sp.nov.,an antimicrobial producing
            actinobacterium isolated from Black Gobi rocks
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9239126)
  AUTHORS   Zhang,W., Liu,X.G. and Wen,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2021) Northwest Institute of Eco-Environment and
            Resources, CAS, Chinese Academy of Sciences, Donggang West Road 320,
            Lanzhou, Gansu 730000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: GS De Novo Assembler v. FEB-2021
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 241.26X
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023277745.1-RS_2024_11_26
            Annotation Date                   :: 11/26/2024 03:43:17
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,438
            CDSs (total)                      :: 8,346
            Genes (coding)                    :: 7,837
            CDSs (with protein)               :: 7,837
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 509
            CDSs (without protein)            :: 509
            Pseudo Genes (ambiguous residues) :: 0 of 509
            Pseudo Genes (frameshifted)       :: 193 of 509
            Pseudo Genes (incomplete)         :: 418 of 509
            Pseudo Genes (internal stop)      :: 17 of 509
            Pseudo Genes (multiple problems)  :: 113 of 509
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:33:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 28341
            Orig. end                         :: 49421
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP086322.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21080
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21080
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21080
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11080](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11080
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    74..85
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.94"
                     /tool="antismash"
     gene            412..771
                     /locus_tag="K9S39_RS00125"
                     /old_locus_tag="K9S39_00125"
     CDS             412..771
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003963854.1"
                     /locus_tag="K9S39_RS00125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_00125"
                     /product="hypothetical protein"
                     /protein_id="WP_248861268.1"
                     /transl_table=11
                     /translation="MNSSSLAPLTGLLAGLPAVLAGALGGAPWWAVGAIVIAAYLAVPL
                     TSLILEHARQRKGTLVDEKFAATLDQITDPEKRIQAIISYRQATAPTPQPPPDPPPGEL
                     PPADPDSANQSPASA"
     gene            1358..1687
                     /locus_tag="K9S39_RS00130"
                     /old_locus_tag="K9S39_00130"
     CDS             1358..1687
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS00130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_00130"
                     /product="hypothetical protein"
                     /protein_id="WP_248861269.1"
                     /transl_table=11
                     /translation="MPEQPDEPPVRWKGLWPIQFPSPTSEGPVLSEEELEARIARATRV
                     QRASELVRALRRHSKEELLRMADEAGLRHDSPRKWRKDEIADAIADHQLRAPAHPTHDP
                     EEEIG"
     gene            <2068..2265
                     /locus_tag="K9S39_RS00135"
                     /old_locus_tag="K9S39_00135"
                     /pseudo=""
     CDS             <2068..2265
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602214.1"
                     /locus_tag="K9S39_RS00135"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_00135"
                     /product="FMN-binding glutamate synthase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="AAVGVAHLALITATDIEIMNGDYEARTLAGVYGYKDGWGELGPHL
                     AEEITALLTTEQSSDQKPPA"
     gene            2388..3179
                     /locus_tag="K9S39_RS00140"
                     /old_locus_tag="K9S39_00140"
     CDS             2388..3179
                     /EC_number="3.4.-.-"
                     /NRPS_PKS="Domain: Abhydrolase_1 (30-144). E-value:
                     2.8e-12. Score: 38.7. Matches aSDomain:
                     nrpspksdomains_K9S39_RS00140_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005485024.1"
                     /locus_tag="K9S39_RS00140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_00140"
                     /product="S9 family peptidase"
                     /protein_id="WP_248861270.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.4e-08, bitscore:
                     33.3, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 4.8e-10, bitscore: 38.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEKVRFSSVVGPELAGAIDLPDGEIRGWGIFVHGFTLGKGSPAA
                     SRVSKQLAREGIGMLRFDNLGIGDSDGDWGDGSFTVKVQDTIRAAAMMAERGTPADLLV
                     GHSWGGAAVLAAAAEATGVRAVATIGAPVDPSHVERQYDAIVDRVLSEGSHEWFVGGRT
                     LVLKRAFVEDVRRAHLRDRIGELDLPLLVLHSPTDNTVDIDNAGEIFREARHPRSFVSL
                     EGADHLLTVRGQAQRAAHIISAWADQYIHGSRPAGETSQVV"
     aSDomain        2478..2819
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K9S39_RS00140_Abhydrolase_1.1"
                     /evalue="2.80E-12"
                     /label="K9S39_RS00140_Abhydrolase_1.1"
                     /locus_tag="K9S39_RS00140"
                     /protein_end="144"
                     /protein_start="30"
                     /score="38.7"
                     /tool="antismash"
                     /translation="IFVHGFTLGKGSPAASRVSKQLAREGIGMLRFDNLGIGDSDGDWG
                     DGSFTVKVQDTIRAAAMMAERGTPADLLVGHSWGGAAVLAAAAEATGVRAVATIGAPVD
                     PSHVERQYDA"
     gene            complement(<3205..>3499)
                     /locus_tag="K9S39_RS00145"
                     /old_locus_tag="K9S39_00145"
                     /pseudo=""
     CDS             complement(<3205..3499)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007379921.1"
                     /locus_tag="K9S39_RS00145"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="K9S39_00145"
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVYLNAGYDSGNIRTTLDHAARPEAGLHTKARKSLSRPPIAGTHA
                     RQNALYRHARCLRTPHQHHQRLLRPRGCRHHRTQPVPTRLDRPPLGRPPHPRP"
     misc_feature    complement(3329..3331)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(3483..3494)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            complement(3511..3723)
                     /locus_tag="K9S39_RS00150"
                     /old_locus_tag="K9S39_00150"
     CDS             complement(3511..3723)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS00150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_00150"
                     /product="hypothetical protein"
                     /protein_id="WP_248869212.1"
                     /transl_table=11
                     /translation="MSQGLLQQVDSTYDVSGESTRSYRTEQIVSSCCSGLEIVSLHRRD
                     VDRALRGVRPYLVDQARRFTESRFL"
     misc_feature    complement(4211..4225)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.76"
                     /tool="antismash"
     gene            <4512..>4919
                     /locus_tag="K9S39_RS00155"
                     /old_locus_tag="K9S39_00155"
                     /pseudo=""
     CDS             4512..>4919
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386618.1"
                     /locus_tag="K9S39_RS00155"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="K9S39_00155"
                     /product="MFS transporter"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIWLTTLGLDSTYAANVLPPLLVTGLGIGLIIAPAMSLATSRVAT
                     EDAGVASASVNTMQQIGGSIGTALLNTLAASAATSYLSGKNPTSKLVQAQAALESYSTA
                     YWWVASFSAAGALITVLLYRRGVPGVDTDTAP"
     gene            5000..5875
                     /locus_tag="K9S39_RS00160"
                     /old_locus_tag="K9S39_00160"
     CDS             5000..5875
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358227.1"
                     /locus_tag="K9S39_RS00160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_00160"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_248861271.1"
                     /transl_table=11
                     /translation="MTSTHEQWDIVSSVGLTALGVASGRAIETARGGLINDPYAAAFVR
                     AVKPVTSLPTSIDEIAEGEPEQVWDRMAGYLGVRSRFFDEYFAAVGIAQVVILAAGLDA
                     RAFRLDWPSGCDLYEVDQPKVLEFKQQVLDEIGARPACRRHAVATDLRDDWVATLTEAG
                     FAPGRPTLWLAEGLLLYLPARAEEALFNEVHQLSAPGSSIALDRAPTHNADFMRNQPTP
                     TFPGLPEFDFTKLISTEPRRNCVDWLRSVGWDVTVESAAEVSARYDHPVHPDFADMMKL
                     GTLVTARRAG"
     misc_feature    complement(5046..5061)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     gene            complement(6060..7313)
                     /locus_tag="K9S39_RS41855"
     CDS             complement(6060..7313)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS41855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_283112057.1"
                     /transl_table=11
                     /translation="MPLTALHDNLRVLDATCDDLDAGIDWDTIYRARPRAPLRCTACHI
                     SVHAKLSPRGRRFFAHDSAAPRCPTNGESPEHRRLKRALALAARQAGWRADVLATTPGG
                     RRLALEAQLSPITYTDITARTYRYATSNVEACWITDTDAPWLLTVPSLQVTTDDATGEL
                     HVTDGHRALSSRPVTGLHAVDFDGDRADHDEIGLRWQHWEEALPDIPVPWTDPWRLLAA
                     HRHDPDDPEDPGALPRANTHRARIGWWRPKRHLTLTRFLTALRHDQVLLLELAAPFRDV
                     SSRVPDPLVWTTPDYLEEAAKLTAFAYGWRLFHRSENNPCSCGTGEPYVLSADTDGCFL
                     YLCSACDAALIDLAADLDSWEARREYVALISDNALMYLTPRQRKRLLPQQPPADAEVTV
                     ETGLTPQEIARRLTGYGK"
     gene            complement(7304..8872)
                     /locus_tag="K9S39_RS00175"
                     /old_locus_tag="K9S39_00175"
     CDS             complement(7304..8872)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606260.1"
                     /locus_tag="K9S39_RS00175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_00175"
                     /product="UvrD-helicase domain-containing protein"
                     /protein_id="WP_248861273.1"
                     /transl_table=11
                     /translation="MPQPTEEQSVVIDAFASGTDLVVQAGAGTGKTTTLEMLAAGDARR
                     GVYISFNKSVAVEAQRRFPQHVKCSTAHGLAFRAVAIPYKHRLNAPRMPAHRVAFGLGI
                     HTHVTLGGKVLEPRNLAYIVLQTVERFCYSAARELSEKHVPVQRGAEEPELHQLLVQAV
                     LPFARKAWEDITDPEGHRVNFKHDHYLKMWQLKDPQLNYDYILLDEAQDTNGVLEAVLD
                     NQRGRAQIVLVGDSAQQIYAWRGAKDIMTGAPGTHLHLSQSFRFGAALAYEANRWLGAI
                     RSTLRLTGHPPLATEIGPLEQPNAVLCRSNAGALTEVLSHLRAGRRVAMAGGGDGLRKL
                     ALAARDLKAGRGTSHPELLLFKTWDELQDYANNDPSGADLLHWVELIDDLGYEEILGSL
                     QRLTDEHTSEVTISTAHKAKGRQWPRVRISDDFPEPDPTEDGKPGRISRSEARLAYVAV
                     TRAQHHLDRGSLAWILDHPAAQPARTTHAAPPGPVPTSPPQKAGYRTWGDLGPLPPTAG
                     EPGCR"
     misc_feature    complement(9349..9363)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.76"
                     /tool="antismash"
     misc_feature    9349..9364
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.19"
                     /tool="antismash"
     misc_feature    9410..9423
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     18.25"
                     /tool="antismash"
     gene            10001..11080
                     /locus_tag="K9S39_RS00180"
                     /old_locus_tag="K9S39_00180"
     CDS             10001..11080
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133196.1"
                     /locus_tag="K9S39_RS00180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_00180"
                     /product="terpene synthase family protein"
                     /protein_id="WP_248861274.1"
                     /sec_met_domain="T1TS (E-value: 3.8e-69, bitscore: 233.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVEFRMPEFHAPFPLECSPHLAEASRGMWGWAELMGLVPTERARA
                     RLRATGADLSGAHVWPRASLSLLTLGCRWLALCFRIDDQLDEDHQGDRPEVCAAVIAEL
                     HRVLDGGVAQDEKGSSVVVRALSALWQETSADTPQHWQDAFIRHFGAFLDSYATEAALK
                     SKGSALYLQEYLRWRRFSVGMPWLFDLVELELPCFLPARVRECAPMRQLRYAAALHIAL
                     VNDVYSLKRESLVGYPCNSVLIIAREQGCSVQQAVDAVADLVAGQARTFITARAELDQE
                     LDRLAVTAGERAAAAAYADTCAVNIRGQIAWHSQVMRYGIEDLRSAPPGDFASYPDDLI
                     GPAREVRSGHERGRGLKAP"
     misc_feature    10664..10666
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(11542..>11907)
                     /locus_tag="K9S39_RS00185"
                     /old_locus_tag="K9S39_00185"
                     /pseudo=""
     CDS             complement(11542..>11907)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019151.5"
                     /locus_tag="K9S39_RS00185"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_00185"
                     /product="HNH endonuclease family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="AYDGKAFTNARQLDIDHVVPLAEAWDSGASKWTAERRERYANDLD
                     APRSLIAVSLGSNRSKGDKDPTEWMPPAKDDTCTYATEWVASKLRWKLTVDRAERKALR
                     AVDAGCKNATVTFRPAL"
     gene            complement(11947..12249)
                     /locus_tag="K9S39_RS00190"
                     /old_locus_tag="K9S39_00190"
     CDS             complement(11947..12249)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS00190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_00190"
                     /product="hypothetical protein"
                     /protein_id="WP_248861275.1"
                     /transl_table=11
                     /translation="MYRALRLAVLVCPVLLLSVAACTPSGSHHDAKSSPSADASDDKNS
                     GKGVPLGEAIGRLKTARESRAGYDRDKFRLWIDADKDGCDTRKEVLISEAVVKPR"
     gene            complement(13485..>13703)
                     /locus_tag="K9S39_RS00195"
                     /old_locus_tag="K9S39_00195"
                     /pseudo=""
     CDS             complement(13485..>13703)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003995364.1"
                     /locus_tag="K9S39_RS00195"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_00195"
                     /product="DNA helicase"
                     /pseudo=""
                     /transl_table=11
                     /translation="RRKGREWPRVRIANDFTPPEDSEERDETGRPVPGPIDDAEARLAY
                     VAITRARQHLDLGGLSWINEHPAGRPS"
     gene            complement(13832..14089)
                     /locus_tag="K9S39_RS00200"
                     /old_locus_tag="K9S39_00200"
     CDS             complement(13832..14089)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K9S39_RS00200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K9S39_00200"
                     /product="hypothetical protein"
                     /protein_id="WP_248869213.1"
                     /transl_table=11
                     /translation="MPATPARGQLALPASQMAVYNRNNHLPYSEQLRWRAQRCPAHAAS
                     PQAPDLAFAEWEVFDPLLHHAHIHPRLPTVSRRPRSAADR"
     gene            complement(<14372..14659)
                     /locus_tag="K9S39_RS42590"
                     /old_locus_tag="K9S39_00205"
                     /pseudo=""
     CDS             complement(<14372..14659)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039647.4"
                     /locus_tag="K9S39_RS42590"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_00205"
                     /product="DUF6083 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRSACPVRRPRALRLAPDSPSRLLRTAQPARCRHCGNHLDWYSRT
                     DEHPIGLHPHEVPASAVPARHRWHVSSGIAHPAHDGTPWCRIPHTPSAPPA"
     gene            14726..15637
                     /locus_tag="K9S39_RS00210"
                     /old_locus_tag="K9S39_00210"
     CDS             14726..15637
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003991694.1"
                     /locus_tag="K9S39_RS00210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_00210"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_248861276.1"
                     /transl_table=11
                     /translation="MELLHLRYFVAVAQELNFSTAARKLHMAASPLSRRIKDLENELGH
                     RLFDRDTHHVTLTEAGIALLPIARGVLEQVDSIRWRLDETTRPGRTTLLVGVPSGIHPD
                     LRERLYDLAERVRDRFEIKRWPGGTERLVDAVCDGRLALTLARLPAGGDPALEQLPVMS
                     ERLGAVVPRDRFSGRESVALAELSELAYAGSPSAVTNAYFRGLDQQLSELGIKKRIELG
                     SATFDGISEIVASGLAFSISMLDPRSPMQNYRLDNVMVLPFSDFQPRLETGLLWRKDRA
                     SHGDLTEVVAAARAIFSEPLRD"
     misc_feature    15689..15698
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.9"
                     /tool="antismash"
     gene            15789..16955
                     /locus_tag="K9S39_RS00215"
                     /old_locus_tag="K9S39_00215"
     CDS             15789..16955
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009719781.1"
                     /locus_tag="K9S39_RS00215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_00215"
                     /product="CaiB/BaiF CoA-transferase family protein"
                     /protein_id="WP_248861277.1"
                     /transl_table=11
                     /translation="MTENTDTVAGPLDGVRVIDLSAVVMGPYAAQILGDLGADVIKIES
                     PADAVRVGHYRTTPGMTPLNLNVNRNKRSVSLNLKDATEGEQALRLIDTADVLITNMRP
                     GALNRLGLSYDDIAARNPGLVYAHAQGFRSDSDRAGNAAYDETVQAASGLVDIAGRALG
                     EPVYLPTILADKVSSLTIAYSVLAALLHRNRTGQGQLVEIPMADTLIAFNLVEHLAGHT
                     HVPETGPTGFPLSMLKGHRAVRTKDGLACVIPYNPQNYRDFVTAAGRPDLAEDPRINGD
                     ALDSADHEELAALIELCAPALTTAEWAEVCAKHSIPMAPVLELDRAHEDPYVRDGHLLD
                     AVEHPTEGTVRTIGIPLRFSATPGTIRRLAPVAGQDTEEVLAELDAAR"
     gene            17033..17827
                     /locus_tag="K9S39_RS00220"
                     /old_locus_tag="K9S39_00220"
     CDS             17033..17827
                     /NRPS_PKS="Domain: ECH (20-255). E-value: 2.1e-58. Score:
                     189.4. Matches aSDomain:
                     nrpspksdomains_K9S39_RS00220_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014151209.1"
                     /locus_tag="K9S39_RS00220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_00220"
                     /product="crotonase/enoyl-CoA hydratase family protein"
                     /protein_id="WP_248861278.1"
                     /transl_table=11
                     /translation="MSIPETPEAPEAPVVRTERIGSTLLITLDRPEARNAVNASVAAGL
                     SGALDALEADPELRAGVLTGEGGTFSAGMDLKAALHGESPEVAGRGFGGLTEAEPTKPL
                     IAAVEGWAMGGGFELALACDLIVAAEDARFGLPEVKRGLIAAGGGVIRLPKRIPHHLAM
                     ELLLTGEPVDGRRAGELGLANRVTATSQVVAEALRLAGRLAENAPLAMAAVKRVVRAAD
                     GTPDADAFAFQRKQMETLMASSDVREGMTAFAERRPARWTGR"
     aSDomain        17093..17797
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K9S39_RS00220_ECH.1"
                     /evalue="2.10E-58"
                     /label="K9S39_RS00220_ECH.1"
                     /locus_tag="K9S39_RS00220"
                     /protein_end="255"
                     /protein_start="20"
                     /score="189.4"
                     /tool="antismash"
                     /translation="GSTLLITLDRPEARNAVNASVAAGLSGALDALEADPELRAGVLTG
                     EGGTFSAGMDLKAALHGESPEVAGRGFGGLTEAEPTKPLIAAVEGWAMGGGFELALACD
                     LIVAAEDARFGLPEVKRGLIAAGGGVIRLPKRIPHHLAMELLLTGEPVDGRRAGELGLA
                     NRVTATSQVVAEALRLAGRLAENAPLAMAAVKRVVRAADGTPDADAFAFQRKQMETLMA
                     SSDVREGMTAFAE"
     gene            17834..18580
                     /locus_tag="K9S39_RS00225"
                     /old_locus_tag="K9S39_00225"
     CDS             17834..18580
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003991697.1"
                     /locus_tag="K9S39_RS00225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_00225"
                     /product="acetoacetate decarboxylase"
                     /protein_id="WP_248861279.1"
                     /transl_table=11
                     /translation="MRTEDVRQHLTTPLTSPAFAPMVPRFIDREYLNVVYRTDPDALRA
                     VVPEPLRIAEPLVRFEVMKMGDVSGYGPYTEAGQAIPVSFEGEDGEYLHAMYLDNFPAT
                     ASGREVSAYPKVIGSPALYVDSGALVGTLDHGTLRVATATMGYKHHELDRQEAEAQITV
                     PTFMLKIVPGYDGLPRVQELVRTRITDVTVKQAWTGPARLQLFQHVLAPLADLPVIEVV
                     SASHILTDLTLSGVEPVHNYLKGTAS"
     gene            18577..19527
                     /locus_tag="K9S39_RS00230"
                     /old_locus_tag="K9S39_00230"
     CDS             18577..19527
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /GO_process="GO:0006631 - fatty acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003991698.1"
                     /locus_tag="K9S39_RS00230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_00230"
                     /product="3-hydroxyacyl-CoA dehydrogenase NAD-binding
                     domain-containing protein"
                     /protein_id="WP_248861280.1"
                     /transl_table=11
                     /translation="MTRTFRTAAVIGAGTIGLSWTALFAAHGLTVRVSDPRPDLAQAVN
                     EALAQYTPHLAARGLDVTGLADRVHLTDDVTEAVRDADVVQENGPERLEFKQDLFATLV
                     REAPGHALLLSSSSAIPSTAFTRELADADAARVLIGHPFNPPHLVPLVEVVPGERTGED
                     AVRDAVDFYASVGRTPVVERKEIPGFVGNRLQNALSREAVYLVEQGVVTPEDLDKVMTN
                     SLGIRWSTVGPFLGSHLGGGPGGYRHLVEHIGASMKQMWAGLGNPSQNEEEQERLIKAV
                     ESAYGSSTYSELTETRDRKQLAVLSALDSADKEEN"
     gene            19529..20731
                     /locus_tag="K9S39_RS00235"
                     /old_locus_tag="K9S39_00235"
     CDS             19529..20731
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003991699.1"
                     /locus_tag="K9S39_RS00235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K9S39_00235"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_248861281.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 3.7e-19, bitscore:
                     68.4, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.1e-21, bitscore:
                     75.7, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 8.6e-28, bitscore:
                     96.4, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTMEPLEDQLVADFYNYETLLPDEERKILLKARTLMRDEVQPL
                     VNGNWGKGEFPKELIDIFRESGLAGLPYEGYGEHRPAVSNLLTGMLAMEMTRTDASVAT
                     FFGVHNGLAMYSIHSGGNQEQRDRWLPAMAAMEKIGAFAMTEPLGGSDVAGGMRTTARR
                     EGDTWVLNGAKKWIGNATFADYVVVWARDVDDNHVKGFVVEKGTPGFEPVKIEGKIAFR
                     IVENAEITLTDVRVPEANRLQNINSFRDVAEILRATRGGVAWQALGAMIGAYELALDYA
                     KERKQFGRPIARFQLVQDLLVKSLGNITASWGMLVQLARLQDAGIFRDEHSSLAKAFVT
                     SRMREVVAWSREIFGGNGIVLDYDIARFFADAEAIYSFEGTREMNTLIVGKSITGQSAF
                     V"
ORIGIN
        1 cgatactggt gagcagatct ggcgtgcccg caggaggatg cacgcagcca gcgagtagaa
       61 gaaaggcggc gcggaaaagg ttaaatgaac cggcttaagg gctttatcag ccttcttttt
      121 gtgggctact gcatgtagcc caccctgccc aaaaagccga agaaatcctc ccccgctaaa
      181 accgccgaac aacccctcta aaccacccca cgaggccagc gaaccggtct cccgaggggc
      241 tgacaggcct gccctaaaac actaccggcc cgccccacag cggcgccggt cctcggcatg
      301 ccctcacacc acggcacacc cgtgccgcct ctccccgtcc cagccgtccc cgcacggctc
      361 gttcaggcat gaggcggccc agccgtcacg tgctggaagg gcatccacgc gatgaactcg
      421 tcgtccctcg cccccctcac cggcctcctg gccggactcc ccgcggtcct cgccggcgcc
      481 ctgggcggtg caccctggtg ggccgtcgga gcgatcgtca tcgcggcata cctcgccgtc
      541 cccctcacca gcctgatcct cgaacacgcc agacaacgaa aaggaacact cgtcgacgag
      601 aaattcgcag ccacactgga ccagataaca gaccccgaaa aaagaatcca agccatcatc
      661 agctaccggc aggccacagc tcccaccccc caaccacccc ccgacccacc accaggagaa
      721 ctaccacccg cagacccaga cagcgccaac caatcaccgg catccgcata gacgaggacg
      781 gccggggctc tggcggggcg cgccgcccgc aggacgatct tgcgggacgt gcctccttcg
      841 gctcagcacg cggctgccgg ggctaggggc agctgcccaa cggcggcggc ccgcagggcg
      901 gtttcgacaa ggccgcgatg gcccgccggg ggctgaaggc tgggccgcaa gcccccggat
      961 aacgatgtag tcgcgcaggg cggcgttaca caggctgctg ttctgcttgc cgtgcagcag
     1021 acccaggagg gacaccacta cctaccagcg atcactggac ctgatccctg accaaccaca
     1081 agtgacacga cctgatcacc cggcctgcta cctgacaaac ccgcaggtca gcccccacca
     1141 tcaagatccg ctcccacaat cgcacccacc tccgaagcgc ccgcaccacc cgaccacacc
     1201 agcgcaccaa actgacaacc ccaagccagc tcaccaacca ctgatcagaa aaaccgctcc
     1261 tggacaccag cagctggccg aactcggact cgactgggcg ggcgcggcac cgggaatgtc
     1321 tgaaggtgcc ccgctcgccg cccgtcagga tgaggacgtg cccgagcagc ccgacgaacc
     1381 gcccgtgcgc tggaagggcc tctggcccat ccagttcccc tcccctacct ctgagggacc
     1441 tgtcctgtcc gaggaagaac ttgaggcccg catcgcgcgc gccacgcgag tacagcgagc
     1501 cagcgagctg gtgcgcgcac tgcgccgtca ttccaaggag gaactgctgc gcatggccga
     1561 cgaggccggt ctgcgccacg actccccgcg gaaatggcgc aaggacgaga tcgcggacgc
     1621 catcgcggac catcaactca gggcccctgc ccaccccacc catgaccccg aggaggagat
     1681 cggctgaaca tcgggcagta cgacgcgtgg gtgaaagagc gccaggaggc gaaggaggaa
     1741 ctgaaggccc aggtgtgtct acccacaggc cgctacggga gctgcccgcc gctgcctgcc
     1801 ggccatctcc agcgcgtcct cccgctgccg ccataccccc tgagaagttg cgggggatgt
     1861 ggaggtagcg gcgtgggtcg gtctgttccg cctaccggtc tgcgcaatgt tgacccgggc
     1921 tttcgtcacc ggtgacacaa aaggttggca gagaacgtca gtcaccatgc ctgctcaggc
     1981 cggtctttcc actgacatcg cgagacgatc aatgactgcc agtcccacgc agaccatcag
     2041 tgtggctaag caaccagaag gcacgacgcg gccgtcggtg tcgcccacct ggcgctcatc
     2101 acggccacgg acatcgagat catgaacggc gactacgagg cccgcaccct ggccggcgtc
     2161 tacggctaca aggacggctg gggcgaactc ggcccgcacc tcgccgagga gatcaccgca
     2221 ctgctcacca ctgagcagtc ctccgaccag aagccgcccg cctgacgcgc cgatcacggc
     2281 aggcaccgcg ctcgctgctc ccctgcccgg agcgcgcgcg tggcgccggc tggtggcacc
     2341 cttgtcttcc ctgctccacg aacagtccct gcctaggtga tcacaacatg agcgaaaaag
     2401 tgagattttc gagcgtcgtc ggccccgaac tggccggagc gatcgacctg ccggacggcg
     2461 agatccgcgg ctgggggatc ttcgtgcacg gattcacgct cggcaagggc tcgccggccg
     2521 cgtcgcgtgt cagcaagcag ttggcacgcg aggggatcgg aatgctgcgc ttcgacaacc
     2581 tcggaatcgg ggactccgac ggcgactggg gggacggttc cttcaccgtc aaggtccagg
     2641 acacgatccg tgccgcagcc atgatggcgg agcgagggac tccggcagac ctgctggtgg
     2701 ggcactcatg gggaggcgcc gccgtcctcg ccgcggcggc tgaggcaacc ggcgtccgcg
     2761 cggtcgccac gatcggagcg ccggtcgatc ccagccacgt cgagcgacag tacgacgcga
     2821 tcgtggatcg cgtgctcagt gaagggtcgc acgagtggtt cgtcggcggg aggaccctgg
     2881 tcctcaagcg cgccttcgtc gaagacgtcc gccgtgctca cctgcgggat cggatcggcg
     2941 agttggacct gccgctactc gtcctgcatt cgccgaccga caacaccgtc gacatcgaca
     3001 acgccggaga gatcttccgc gaggcacgac acccgcgaag cttcgtctca ctcgaaggag
     3061 cagaccatct cctgaccgtc cgaggacaag cacagcgagc cgcccacatc atcagcgcct
     3121 gggccgacca gtacatccac gggtcacggc ccgcaggaga gacatctcag gtggtttagt
     3181 gctcgctcgg acaggtacgg ggtcagggtc gcgggtgggg cggtcttccc agcggtgggc
     3241 ggtccaggcg cgtcggaaca ggctgcgtac ggtgatgacg gcatccgcga ggccgaagaa
     3301 ggcgttgatg atgctggtgc ggtgttcgta agcagcgtgc gtgccggtag agggcgttct
     3361 gacgggcgtg ggtgccagcg atgggtggcc tggagaggga ctttctcgcc ttggtgtgca
     3421 atccggcctc cgggcgggcc gcatggtcga gagtggtgcg gatgttgccc gagtcgtagc
     3481 cggcgttcag gtacacggtc agaactgcag ctacaggaaa cgagactcgg taaagcgccg
     3541 ggcctggtcg acaaggtaag gccgcacccc gcggagcgca cggtcgacat cgcgccgatg
     3601 caggctgacg atctccaggc cgctgcagca agaggacacg atctgttcgg tgcggtacga
     3661 ccgggtgctc tcccctgaga cgtcgtaggt gctgtcgacc tgctggagca gcccctggct
     3721 cacactgccg cctctcatta agtcccccgt gccgcgcacc agcgccccgg gcacgaagcc
     3781 cagtactcgt ggcacgacgc gaccgcctgg acgacaccca gctcgccgca ctcgccgacc
     3841 tcggactcga ctgggtgtga aggccctggg ggacgttcgg gccattacct gatcggctga
     3901 tgagcagttg aggctgcgtg caagcgatag gtgcggcggg gcatggggat gtcggagaag
     3961 gcgatgttgc tctcgttgac gtgcggttcc ttggtccgct gaggggtgaa gcgcgtgcgc
     4021 ggtggcggga ggcggctgcg gaggtggcgt tcgagggcgc ttgccacaga ccaacaatca
     4081 gtgaagatga tcagcgctca ctacaagtga caagaactga tcatgcgtcc ctcaacatga
     4141 caaaccgcca ggtcaacgcc cccggcacag caccccaacc cccagagatc acaactcccc
     4201 caacaaaccc ctctcataca gagaactgat caacccaggt cacaacacca ggccctgatc
     4261 acaaaaactg ctcccggaca cgcggcaagc tcaccgccga caaactccaa cagctggccg
     4321 acctcggact cgactgggca tgacctgggc cgggcgtagg ccgaaggcgg tctacgcccg
     4381 gtacgtggca tcggcgtggt cgatgtacgc ggcggccatg gccgcgacgc cccttgcggg
     4441 aacgccgcac accaagaccc ccactctctg cccgttgaca ccgatgcgga ccagtcccca
     4501 gccccacagc gatgatctgg ctgaccaccc tcggcctgga cagcacatac gcagccaacg
     4561 tcctgccccc gctactggtc accggcctcg gcatcggcct gatcatcgcc ccagccatga
     4621 gcctggccac cagccgcgtg gccaccgagg acgccggagt cgcctccgcc tccgtcaaca
     4681 ccatgcagca gatcggcggc tccatcggca ccgccctgct caacaccctc gccgccagcg
     4741 ccgccacgtc ctacctgagc ggcaagaacc ccaccagcaa gcttgtccag gcccaggccg
     4801 cgctggagtc ctactccacc gcatactggt gggtagccag cttctccgca gccggcgcac
     4861 tgatcaccgt gctgctctac cggcgcggcg tccccggggt cgacacagac accgccccta
     4921 ccaccgacac cgcaaaggga gaagggacga cccgcggaac tacccggacc ggaactttga
     4981 cagtgatcgg agacacacta tgaccagcac acatgagcag tgggacatcg tgtcgagcgt
     5041 cggcctgacc gcgctcggcg tcgcgtccgg gcgtgcgatc gagaccgcgc gcggcggctt
     5101 gatcaacgac ccctacgccg ccgcattcgt ccgcgccgtg aagccggtga cctcgctgcc
     5161 caccagcatc gatgagatag ccgaggggga gccggagcag gtttgggacc gcatggccgg
     5221 ctacttgggc gtacgctccc ggttcttcga cgagtatttc gccgccgtag gcatagccca
     5281 ggtggtgatc ctggccgctg gactggacgc ccgtgccttc cggctggact ggccgtcggg
     5341 ctgcgacctg tacgaggtcg accagccgaa ggtactggag ttcaagcagc aggtgctcga
     5401 cgagatcggc gcccgcccgg cttgccgcag gcacgcggtg gcgaccgacc tacgcgacga
     5461 ctgggtcgcc acgctcaccg aggcgggctt cgcccccggc aggcccacgc tgtggctcgc
     5521 cgaaggcctg ctgctttacc tgcccgccag ggcagaggaa gccctcttca acgaggtgca
     5581 ccagctgtcc gcgccgggca gctcgatcgc cctcgatcgg gcgcccaccc acaatgcgga
     5641 cttcatgcgg aaccagccga ccccgacctt ccccggcctg cctgaattcg acttcaccaa
     5701 gctgatcagt accgaaccgc gtcgcaactg cgtcgactgg ctgcgctcag tgggctggga
     5761 cgtgaccgtt gagtcggccg ccgaggtctc ggcgcgctac gaccaccccg tgcaccctga
     5821 cttcgcggac atgatgaagc taggcacgct ggtcacggct cgccgcgcgg gttgaccagg
     5881 gcgcgggctg ggtcgctggc tggtcggcgg tgtgctcgct catcatgcga ctcctgatcg
     5941 gctgatggac ttcacggtaa cgcccaccag ggagccggtg ggcgggatag gagaagccag
     6001 acgcgcgcgg ccacgcggcg ccggcgcctg gacgcgttcc agggccatgc gtcccgtgtt
     6061 cactttccgt atccggtcag gcgccgggcg atctcctgag gggtcagccc tgtctctacc
     6121 gtgacctcgg catccgccgg gggctgctgc gggagaagcc gttttcgttg ccggggcgtg
     6181 aggtacatga gggcgttgtc ggagatcagc gcgacgtact cgcggcgggc ctcccagctg
     6241 tccaggtcgg cggccaggtc gatgagggcg gcgtcgcagg cggagcacag gtagaggaag
     6301 cagccgtcgg tgtcggcgct gagcacgtag ggctcgccgg ttccgcagga gcacgggttg
     6361 ttctcgctgc ggtggaagag ccgccagccg taggcgaagg cggtgagctt ggcggcctcc
     6421 tccaggtagt cgggcgtggt ccacaccagc gggtccggaa cgcggctgga gacgtcgcgg
     6481 aagggggcgg cgagttccag cagcaggacc tggtcgtgac gcagggcggt gaggaaccgg
     6541 gtgagggtca ggtgccgctt gggccgccac cagccgatac gggcacggtg ggtgttcgcg
     6601 cggggcagcg caccagggtc ctccgggtcg tccgggtcgt ggcggtgggc cgccaggagg
     6661 cgccacgggt cggtccaggg cacggggatg tcggggaggg cttcttccca gtgctgccag
     6721 cgcaggccga tctcgtcgtg gtcggcgcgg tcgccgtcaa agtcaacggc gtggaggcca
     6781 gtgacgggtc tgctggacag ggcgcggtgg ccgtcggtga cgtggagttc tcccgtggcg
     6841 tcgtccgtgg tgacctggag ggaggggacg gtgaggagcc agggggcatc ggtgtcggtg
     6901 atccagcagg cttcgacgtt gctggtggca tagcggtagg tgcgtgcggt gatgtcggtg
     6961 taggtgatgg gggagagctg ggcttcgagg gccaggcggc ggccgccggg ggtggtggcg
     7021 aggacgtcgg cgcgccagcc ggcctggcgg gcggcgaggg cgagggcgcg tttgaggcgg
     7081 cggtgctcgg ggctttctcc gttggtgggg cagcgtgggg cggcgctgtc gtgggcgaag
     7141 aagcggcggc cgcgggggga gagcttggcg tggacgctga tgtggcaggc ggtgcagcgc
     7201 agtggggcgc gggggcgggc tcggtagatg gtgtcccagt cgatgccggc gtcgaggtcg
     7261 tcgcaggtgg cgtcgaggac tcggaggttg tcgtggaggg cggtcagcgg catcccggct
     7321 ctcccgcggt gggtgggagg gggccgaggt cgccccaggt cctgtaaccg gccttctggg
     7381 gcgggctggt ggggacgggg ccgggtgggg ccgcgtgggt ggttcgagcg ggttgggcgg
     7441 cggggtggtc gaggatccag gccaggctgc cgcggtcgag atggtgctgg gcgcgggtga
     7501 cggcgacgta ggccaggcgg gcttcggagc gggagatgcg gccgggcttg ccgtcttcgg
     7561 tggggtcggg ttcggggaag tcgtcgctga tgcgtacccg gggccattgg cggcctttgg
     7621 ccttgtgggc ggtggagatg gtgacctccg aggtgtgctc gtcggtcagg cgctggaggg
     7681 agccgaggat ctcctcgtag ccgaggtcgt cgatgagttc gacccagtgc agcaggtcgg
     7741 cgccggaggg gtcgttgttg gcgtagtcct ggagttcgtc ccaggtcttg aacagcagca
     7801 gttcggggtg gctggtgccg cggccggcct tgagatcgcg ggcggccagg gcgagcttgc
     7861 gcagcccgtc gccgccgccg gccatcgcga cgcggcggcc ggcccgcagg tgggacagga
     7921 cctcggtcag ggcgccggcg ttggagcggc acagcaccgc gttgggctgc tccagcgggc
     7981 cgatctcggt ggccagggga gggtggccgg tcaggcgcag ggtggagcgg atcgcgccga
     8041 gccagcggtt ggcctcgtag gcgagggctg cgccgaagcg gaaggactgg gacaggtgca
     8101 ggtgagtgcc gggggcgccg gtcatgatgt ccttggcgcc gcgccaggcg tagatctgct
     8161 gggcggagtc gccgaccagg acgatctggg ctcggccgcg ctggttgtcg agcaccgcct
     8221 ccaggacgcc gttggtgtcc tgggcctcgt ccagcaggat gtagtcgtag ttcagctgtg
     8281 ggtctttcag ctgccacatc ttcaagtagt ggtcgtgctt gaagttgacg cggtgcccct
     8341 cggggtcggt gatgtcctcc cacgccttgc gggcgaaggg caagaccgcc tggacgagca
     8401 gctggtgcag ctcaggctct tcggctcctc gctgtacggg gacatgcttc tctgacagtt
     8461 cccgtgccgc cgagtagcag aaccgctcga cggtctgcag gacgatgtag gcgaggttgc
     8521 gcggttcgag gaccttgccg ccgagggtga cgtgcgtgtg gatgcccagc ccgaacgcga
     8581 cccggtgggc gggcatccgc ggcgcgttga ggcggtgctt gtacgggatg gccacggccc
     8641 ggaaggccag accgtgcgca gtggagcact tcacgtgctg cgggaaacgg cgctgggcct
     8701 ccaccgcgac ggacttgttg aaggagatgt acaccccgcg gcgagcatca ccggcggcga
     8761 gcatctccag cgtggtcgtc ttccctgttc cggcaccggc ctggacaacc aggtcggtgc
     8821 cggaggcgaa cgcgtcgatg acaacggact gttcctcggt tggctgcggc atcggcgcca
     8881 acctcccttc cccgagcagc tcatggcgct cgaatcgttc acgggcacgc cacagcgcat
     8941 gccgtggctg gaggcagcat gcacgcaggc actgacaatc cgtgcccccc agcatcacgc
     9001 aatggaacat gcgcgcggtg gccctgttcg tgcgttcgtc cggccatggc cagtaaccca
     9061 cgtacagcgg cggggcgcct tggtctcttc gctcccggtg accgggccgt tcccggtgag
     9121 cgccgcgccg tcctccaggc cgagcgcggc cttctgtcca cccggccgga catggtcggg
     9181 gggcctcgaa ggcagcggcc ggtccgcgct gcgccgcctg gtcctcgaag acgctcgggt
     9241 ctccattggc taccgcgtcc acgaccaagt cgtcaccgtc gagattgtct ggcttattgg
     9301 ccacttctga cgtccacagc cgacgggagt gggaagcagc agccggggcg gaccgcctgg
     9361 tccgccccgg ctgctcagct gcacggttac gctggccgtg acggtccggg gcactacctt
     9421 tgcctcggac cgtcacgccg cccgatcctg cagcagcacc ttgatcacgt cgttgccggt
     9481 ctgcatcccg gcaacgccgg ccttgagctc cttcacgtcg tcggagagct tctccaggtg
     9541 cggcctaccc cagatggaat ggctctgtag gcgactacca agaacgcctg ttgctcagtg
     9601 gtgagaacac ctgcttccac gagagagtga tgtcgctgag tttcgagaac accccggttc
     9661 ttgcttcggg accctggttg tgctctgcac gatgaggggg cccaggtgct gccgatcgac
     9721 cggagggacc aggaggacga agctcgccgc atccgctccc acccgcacgg atcccgtcac
     9781 cgacaacctg cctgccctcg gacaagcgtg ccatccgccg tcgccagggg ccttgcggcc
     9841 gacttttgat cttgtgctgg caaaggaatg cttgtgagag ttgcgaccgc cgtcgtcctc
     9901 gtcagcgtcg gccccgttcg cgcgtgtagc gatggctgcg caccacacgg agctcgtggg
     9961 gtgccgctcg ttagcgacgc cctgaatcat ggagagatgc atggttgagt tccggatgcc
    10021 ggagttccat gcgccgtttc cgctggagtg cagccctcac ctggcagagg cgtcgcgggg
    10081 gatgtggggg tgggcggaac tcatgggttt ggtacccacc gaacgagcgc gtgccagatt
    10141 gcgcgccacg ggtgccgacc tgtctggggc gcatgtgtgg ccacgcgcca gcctctccct
    10201 gctcaccctt ggttgccgct ggctggcgtt gtgcttccgg atcgacgacc aactcgatga
    10261 ggaccatcaa ggcgaccggc cggaggtgtg cgcggccgtg attgccgaac tgcaccgtgt
    10321 gctggatggc ggcgtggccc aggatgaaaa gggcagctct gtcgtggtcc gggcgttgtc
    10381 ggcgctgtgg caggagacct ctgccgacac accgcagcac tggcaggacg ccttcatccg
    10441 ccacttcggc gcgtttctcg actcctatgc gaccgaggcg gcgctgaaga gcaagggaag
    10501 cgcgctgtat ctccaggagt acctgcggtg gcggcggttc tcggtcggga tgccgtggct
    10561 gtttgacctg gtcgagctgg aactgccctg cttcttgccg gcccgcgtgc gtgagtgcgc
    10621 tcccatgcgt cagctccggt acgccgccgc gctgcatatt gccttagtca acgatgtcta
    10681 ctcgctgaag cgtgagagcc tcgtcggcta cccgtgcaac tcggtcctga tcatcgctcg
    10741 ggagcaggga tgctccgttc agcaggccgt ggacgctgtc gccgacctcg tcgccgggca
    10801 ggcacgtacg ttcatcaccg cccgcgccga actcgaccag gaacttgacc gcctagccgt
    10861 gacagctggc gagcgggcgg cagcggccgc atacgcggac acctgtgccg tcaatatccg
    10921 tgggcagatc gcctggcact cccaagtcat gcgctacggc atcgaagacc tccgctcggc
    10981 gcctccggga gacttcgcaa gctaccccga tgacctcatc ggcccggcac gcgaggtgag
    11041 atccggtcat gaacgcggtc gaggtctgaa ggcgccgtga tgtctgcgga tggccagtcc
    11101 ggcacggtca gctcaggcca ctgcttctgt caccgcgccg ccttggcctc atagaccgac
    11161 cgcggggcaa gcaccgggtt cggccgacac gccgacgagg cgttctcgga ctcgacaaca
    11221 tcttggaccc gcttgatcaa catctgttgc ccgaactcgg catcaaccgt tctcgcgtta
    11281 caccgacgaa gccaggatgg gctcggacga cgactacgaa tggggtcggt gaccggttcc
    11341 gggtgcctgg gcgggggccg tacgctcccc gcccaggcgc ctggagcgta cggccttgga
    11401 cagcaatcgg ccccggccgc tgccccacgg ggggaaaggg caccgtccgg ggtggtttcg
    11461 cccttgttgg ccagttcgag tcgccttggc ggggccgctg acagcgccgc tatgaggtcg
    11521 atcatcgcga ggttgatcag gctacagtgc aggccggaac gtcaccgtgg cgttcttgca
    11581 gcccgcgtcg accgcgcgca gagctttgcg ctcggcgcgg tcgacggtca gcttccagcg
    11641 gagctttgaa gcgacccatt cggtggcgta ggtgcaggtg tcgtccttgg ccggtggcat
    11701 ccactcggtg gggtccttgt cgcctttgga acggttggag cccaggctga cggcgatgag
    11761 gctgcgcggc gcgtccaggt cgttggcgta gcgctcgcgg cgctcggcgg tccacttcga
    11821 ggcgccggag tcccaggctt cggcgagggg gacgacgtgg tcgatgtcaa gctggcgtgc
    11881 gttggtgaaa gccttgccgt cgtaggcaga gtgccatttc cctccggtga gcttgcagtt
    11941 ctagccctag cggggcttga cgacagcttc ggagatgagg acttccttgc gggtgtcgca
    12001 accgtccttg tcggcatcga tccacaggcg gaacttgtct cgatcgtacc cagcacggga
    12061 ttcgcgggct gtcttcagcc ggccaatcgc ctcgccgagc ggcacaccct tcccgctgtt
    12121 cttgtcgtcg gaggcgtcag cactcggaga ggacttcgcg tcatggtggg aaccgcttgg
    12181 cgtacacgcg gccacggaca gcagcaggac ggggcaaacg aggactgcca ggcggagcgc
    12241 gcgatacatg gaactccagt caggtgggac aacatcaaca gcgatgaatc tgcccaccgt
    12301 ttcacgtgcc ttccccctcc ctgcagctcg ttacccttcg caggcggctc gtacgtagcg
    12361 gcacgcgaac ctcatcacct actgaccttt tcgaagggtt gtcggatctg ggctatgtcg
    12421 agggcgatgg gagaccagtg ccggtcaggc acccgtcgat gagatggggt ctgcgttgga
    12481 tgcggcgcat gccgctacgg acggcatgga cgagatcctc gcggtcggcg tacaccatgt
    12541 tggccgtggt ggcccgtcgt agcagcgacc gggacgggcg caaccggctg ccgtgcccca
    12601 tctcgcgcga gtcgagcagt tccggatcag ctgaaagtcc gcgatcacga ggtcgactgg
    12661 cacctggaac tggactggat ctgcgcaggc cgcgagcaaa ccctccggat accgaactcc
    12721 gggcactaca cgcactgccc gatccagtcg tggcttgacg taagcgcgac cctggcccga
    12781 aacgtggtca ggttgctgca gcacggaaag aaacggccgg tccgggtcgc ggaggctcgt
    12841 gtagacccgc gtgcaaacga ccgccgacag gtcatggcgc tgcgcgccac gttcgctggc
    12901 atcagagagg tggatgtgcc gatcgtgccc gacgcgctgc agctgcacgc ctacccagcc
    12961 agcgacgcga ccgagcccgt cagcgaacca cgggcggcta tcgcaatgga cgagtccgtg
    13021 tatgacgacg gcgattgggg acctgaccgg gccagccctg gagaggtccg ggaccggcag
    13081 cgatccgcgg catcgtcgac gagctggccg agcggtaccc gcacaccagc ggcgtacgag
    13141 agttgcacgc cgccgtgaca cagaccgcct gacactcgac cggacaaggc gctccttcag
    13201 cttcacgacg gcgacgaatg gtggtaggtg tcagggcctc cagtgatctg agcccgaact
    13261 ttccgtcctc cagacgtgcc gcacacacga gatgtcctgg aacatctgcc ggtctaaatg
    13321 ccgctgacat ccgggggccg aaatcgcagc tctgccttgc gggcagcaac ggctccatca
    13381 ccgcccggag ttcgaagccc gggcaggtgg ctcgcggacc tcttcgcgga cttgctgctt
    13441 cgggcgaggt actgctcggg gcagcagcgc gctggcgcgc atgctcatga cgggcgtccg
    13501 gcagggtgct cgttgatcca ggacaggccg cccaggtcca agtgttggcg ggcgcgggtg
    13561 atggcgacgt aggccaggcg ggcttcggcg tcgtcaatgg ggccggggac ggggcggccg
    13621 gtctcgtcgc gctcttcgct gtcttcgggt ggggtgaagt cgttggcgat gcggacgcgg
    13681 ggccattcgc ggcctttccg gcgccggcct ggagggcgag gtgatctccg gcgtgaaagt
    13741 ggtctgcctg ctgcggcttg ctcgtcggtg ggcttgagca cgtgaggtcc atgggtcggc
    13801 agtgggtgtg aggcagggga tgcagatggc gctatcggtc ggccgcagaa cgggggcgtc
    13861 gactgaccgt aggcaggcgg gggtggatgt gggcgtggtg caggaggggg tcgaagacct
    13921 cccattcggc gaacgccagg tcaggggcct gcggggaggc ggcgtgggcg gggcatcgct
    13981 gggcgcgcca gcgcagctgt tcgctgtagg gcaggtggtt gttgcggtta tagacggcca
    14041 tctgggaagc ggggagcgcc agttgtccgc gtgccggcgt cgcgggcatg agcgtccagg
    14101 tccccgcagg cgattgctgg gacaggacgc ggcgggtaca gcggtcgcgt tgacgggtct
    14161 gagcgacgca ctggatgtcc tcgagcgggt gtggggcgag gtagcggcag tagaggaggt
    14221 gaccacaggc cgtgccgggc ggcaggcggc gccggttcgg tgggtggggt ggccggcggc
    14281 gtgaaggctc cggtgtcgat gaggtggcgg gtgcgcaggg ccaggcggcg gcgcagttcg
    14341 gcgaactgag gggtgagggg cgcgtcggtg gggcgggtgg ggcagagggg gtgtggggga
    14401 tgcggcacca aggggtgccg tcgtgtgcgg ggtgggcgat gccggagctg acgtgccagc
    14461 ggtggcgggc ggggacggcg gaggcgggaa cctcgtgggg gtggaggccg atggggtgct
    14521 cgtcggtacg gctgtaccag tcgaggtggt tgccgcagtg acggcaccgg gcgggctgcg
    14581 cggtccgcag gagccggctg gggctgtcgg gagcaaggcg cagggcgcgc gggcggcgga
    14641 cgggacaggc ggaccgcatc gtacgcgccc ggcctagccg tacgggcccg gggcgtgcgc
    14701 gcccctacgg gttagggtga gaggcgtgga gcttctgcac ctgcgctact tcgttgccgt
    14761 cgcccaagaa ctgaacttct ccaccgccgc tcgcaaactg cacatggcag cgtccccgct
    14821 gagtcggcgg atcaaggatc ttgagaacga actcgggcac cggctgttcg atcgtgacac
    14881 ccaccatgtg acgctcaccg aggcgggcat cgcgctgctg ccgatcgcgc gcggcgtcct
    14941 ggagcaggtc gactcgatcc ggtggaggct ggacgagacg acccggccgg ggcggaccac
    15001 cctgctggtg ggcgtgccca gcggtatcca tccggacctg cgcgaacggt tgtatgatct
    15061 cgccgagcgg gtccgcgacc ggttcgagat caagcgctgg ccgggcggca ccgagcgtct
    15121 ggtcgacgcc gtgtgcgacg gcagactggc gctgaccctg gcccggcttc cggccggcgg
    15181 cgatccggcg ctggagcagt tgccggtgat gtcggagcgg ctcggcgcgg tcgtgcccag
    15241 ggaccggttc tcgggacggg agtcggtcgc cctggcggaa ctgtccgaac tcgcctacgc
    15301 gggatctcct tcggctgtga ccaacgcgta tttccgcgga ctcgaccagc agctgtccga
    15361 gctcggtatc aagaaacgga tcgaactggg cagcgccact ttcgacggaa tttccgaaat
    15421 cgttgccagt ggtctggcat tctccatttc catgctggat ccgcgaagcc ccatgcagaa
    15481 ttaccgcctg gacaatgtaa tggtccttcc tttctcggat ttccaacccc ggctcgaaac
    15541 tggactgttg tggcgcaagg accgggcgag ccatggcgac ctgacagaag tcgtcgccgc
    15601 tgctcgcgcg attttctccg aaccactccg ggattgattg aagagcgcac ccgggaagcg
    15661 gtatgaccac tgcggtcatg ccgcttttcg ttatttgatc attccacttt ccgcccctcc
    15721 tcgataactt agttttcaga tacacggata catgcgtgag gcgaagtgag gagtggaagg
    15781 aaaaaatgat gacggaaaac acggacaccg tggccggccc gttggacggc gtgcgcgtga
    15841 tcgacctctc ggccgtggtg atgggtccct acgccgcgca gatcctcggc gacctgggtg
    15901 ccgacgtgat caagatcgag tcgcccgccg acgccgtacg tgtgggccac taccgcacga
    15961 caccgggcat gaccccgctg aacctcaacg tcaaccgcaa taagcgcagt gtgtccctca
    16021 acctcaagga cgccaccgag ggcgagcagg cgctgcggct gatcgacacc gcggacgtgt
    16081 tgatcaccaa tatgcgaccc ggtgcgctga accgcctggg tctgtcctac gacgacatcg
    16141 ccgcccgcaa ccccgggctg gtctacgcgc acgcccaggg tttccgcagc gactcggacc
    16201 gggccggcaa cgccgcgtac gacgaaaccg tgcaggccgc gtccggactg gtcgacatcg
    16261 ccggccgcgc gctcggcgag cccgtctacc tgccgaccat cctcgcggac aaggtctctt
    16321 ccctgaccat cgcctacagc gtgctggccg ccctgctgca ccggaaccgg accggccagg
    16381 gccagctcgt cgagatcccg atggccgaca cactgatcgc gttcaacctg gtcgagcacc
    16441 tggcgggaca cacccacgtg cccgagaccg gccccaccgg cttccctctg tcgatgctca
    16501 agggacaccg ggccgtgcgc accaaggacg gactggcctg cgtcattccg tacaacccgc
    16561 agaactaccg cgacttcgtc actgccgccg gacggccgga cctggccgag gacccgcgta
    16621 tcaacggaga cgccctcgac agcgccgatc acgaggagct ggccgcgttg atcgagctgt
    16681 gcgctccggc gctgaccacc gccgagtggg cggaggtgtg cgcgaagcac agcatcccga
    16741 tggccccggt gctggaactg gaccgcgctc acgaggaccc ctacgtccgc gacggccacc
    16801 tgctcgacgc cgtcgagcac cccaccgagg gcacggtccg caccatcggc atcccgctgc
    16861 gcttctccgc cactcccggc acgatccgcc gcctggcgcc ggtcgcgggc caggacaccg
    16921 aggaagtcct cgccgagctc gacgccgccc gctgagcatc acctccccca caacacgccc
    16981 caggggaacg gccgtgcccc gtaccccccg acgggccgtc acaggagcaa ccatgagcat
    17041 ccccgaaaca cccgaagcac ccgaagcacc cgtcgtgcgc accgaacgga tcggctccac
    17101 cctgctgatc accctggacc gccccgaggc ccgtaacgcc gtgaacgcat cggtcgccgc
    17161 cggcctgagc ggcgcactgg acgcgctgga ggccgacccc gagctgcgcg ccggcgtcct
    17221 gaccggcgag ggcggcacgt tcagcgctgg catggacctc aaggcggcac tgcacggtga
    17281 gtcacccgag gtcgccggcc gcgggttcgg cggcctgacc gaggccgagc cgaccaagcc
    17341 cctgatagcc gccgtggagg gctgggccat gggcggcggc ttcgaactgg ccctggcctg
    17401 cgacctgatc gtcgcggccg aggacgcccg gttcggcctg cccgaggtca agcgtggcct
    17461 gatcgccgcg ggcggcggcg tgatccggct gcccaagcgc atcccgcacc acctggccat
    17521 ggagctcctg ctgaccggcg agcccgtcga cggccgccgc gccggcgaac tgggcctggc
    17581 caaccgggtc accgccacca gccaagtcgt cgccgaggcg ctccggctgg ccggacggct
    17641 cgcggagaac gccccgctcg caatggcggc cgtcaagcgc gtcgtccgtg ccgccgacgg
    17701 tacgcccgac gccgacgcct tcgccttcca gcgcaagcag atggagaccc tgatggcctc
    17761 ctcggacgtg cgcgagggca tgaccgcctt cgccgagcgc cgccccgcgc ggtggacggg
    17821 gcggtgaggc gccatgcgca ccgaggacgt acgacagcac ctcaccaccc cgctcaccag
    17881 cccggcgttc gcgccgatgg tcccgcggtt catcgaccgg gagtacctca acgtcgtcta
    17941 ccgcaccgac cccgacgcgc tgcgggccgt cgtccccgaa ccgctgcgga tcgccgagcc
    18001 gctggtccgg ttcgaggtga tgaagatggg cgacgtcagc ggatacggcc cctacacgga
    18061 ggccggccag gcgatcccgg tcagcttcga gggcgaggac ggcgagtacc tgcacgcgat
    18121 gtacctcgac aacttcccgg cgaccgcctc cggccgtgag gtctccgcct acccgaaggt
    18181 catcggctcc ccggcgctct acgtcgactc cggcgcgctc gtcggcaccc tcgaccacgg
    18241 cacgctgcgg gtcgccaccg cgaccatggg ctacaaacac cacgagctgg accggcagga
    18301 ggccgaggca cagatcaccg tgccgacctt catgctcaag atcgtccccg gctacgacgg
    18361 gctgccacgg gtgcaggaac tcgtccgcac ccgcatcacc gacgtcaccg tcaagcaggc
    18421 gtggaccggc cccgcccggt tgcagctgtt ccagcacgtg ctcgccccgc tggccgacct
    18481 gccggtgatc gaggtcgtct ccgccagcca catcctcacc gacctgacgc tgtccggcgt
    18541 cgagccggtc cacaactacc tgaagggaac cgcgtcatga cccgcacctt ccgcacggcc
    18601 gcggtgatcg gcgccgggac catcggactg tcctggacgg cgctgttcgc cgcgcacggc
    18661 ctgaccgtcc gggtgagcga cccgcgaccc gacctcgccc aggccgtgaa cgaggccctg
    18721 gcccagtaca ccccgcacct ggccgcccgc ggcctggacg tgacgggcct cgccgaccgg
    18781 gtgcacctca ccgacgacgt caccgaagcg gtccgggacg cggacgtcgt ccaggaaaac
    18841 ggccccgaac gcctcgaatt caagcaggac ctgttcgcca ccctggtccg ggaagcgccc
    18901 ggccacgcgc tgctgctcag ctcctcgtcg gcgatcccat cgaccgcgtt cacccgggag
    18961 ctggcggacg ccgacgccgc ccgcgtcctg atcggccacc ccttcaaccc gccgcacctg
    19021 gtccccctgg tcgaggtcgt gcccggcgag cgcaccggcg aagacgccgt acgggacgcg
    19081 gtggacttct acgcctcggt cggccgcacc ccggtcgtcg agcgcaagga gatccccggc
    19141 ttcgtcggga accggctaca gaacgcgctc agccgcgagg cggtgtacct ggtcgagcag
    19201 ggcgtcgtga ccccggaaga cctcgacaag gtgatgacga actcactcgg catccgctgg
    19261 tcgacggtcg ggccgttcct cggctcccac ctgggcggtg gccccggcgg ctaccggcac
    19321 ctggtcgagc acatcggcgc gtcgatgaag cagatgtggg caggcctcgg caacccatca
    19381 cagaacgaag aagaacagga acggctcatc aaagccgtgg aatcggctta cggctcctcc
    19441 acgtactcgg aactcaccga gacgcgcgac cgcaagcaac tcgctgtcct gtccgccctg
    19501 gacagtgccg acaaggagga gaactgagat gaccaccact atggaaccgc ttgaggacca
    19561 gctggtcgcg gacttctaca actacgagac cctgctgccg gacgaggagc gcaagatcct
    19621 cctcaaggcc cgtaccctca tgcgcgacga ggtccagccg ctggtgaacg ggaactgggg
    19681 caagggcgag ttccccaagg aactcatcga catcttccgc gagagcgggc tggccggact
    19741 gccctacgag ggctacggcg agcaccgccc cgccgtcagc aacctcctga ccggcatgct
    19801 ggccatggag atgacccgca ccgacgcctc ggtggccacc ttcttcggcg tccacaacgg
    19861 cctcgcgatg tactcgatcc actccggcgg gaaccaggag cagcgcgacc gctggctgcc
    19921 ggcgatggcc gcgatggaga agatcggcgc attcgcgatg accgagcccc tcggcggctc
    19981 cgacgtcgcg ggcggtatgc gcaccaccgc ccggcgcgag ggcgacacct gggtcctgaa
    20041 cggcgccaag aagtggatcg gcaacgcgac cttcgccgac tacgtcgtgg tgtgggcgcg
    20101 ggacgtcgac gacaaccacg tcaagggctt cgtcgtcgag aagggcacgc ccggcttcga
    20161 gccggtgaag atcgagggca agatcgcctt ccggatcgtg gagaacgccg agatcaccct
    20221 gaccgatgtc cgggtgccgg aggcgaaccg tctgcagaac atcaactcct tccgcgacgt
    20281 cgcggagatc ctgcgtgcca cccgcggcgg ggtcgcctgg caggcgctgg gagcgatgat
    20341 cggcgcctac gaactcgcgc tggactacgc caaggagcgc aagcagttcg gccgcccgat
    20401 cgcccggttc cagctggtgc aggacctgct cgtcaagagc ctgggcaaca tcaccgcctc
    20461 gtggggcatg ctggtgcagc tcgcccggct gcaggacgcc gggatcttcc gcgacgaaca
    20521 ctcctcgctg gccaaggcgt tcgtcacctc gcgcatgcgg gaggtcgtcg cctggagccg
    20581 tgagatattc ggcggcaacg ggatcgtgct ggactacgac atcgcgcggt tcttcgccga
    20641 cgccgaagcg atctactcct tcgaaggcac ccgcgagatg aacaccctca tcgtcggcaa
    20701 gtcgatcacg ggccagagcg ccttcgtgtg accccgccgc cgggacgcca ccggcccgga
    20761 cggacagacc ccaggttccc tgcctgtggt ttcgtccacg aacttgttga ggtgccctgg
    20821 ccgggcgtga ctgatgtgac gattcggccg ttcgggaggg tgtgagtgct cggccgtgga
    20881 tcgtggatga cgacttgtgg atgctgatcg agccgctgct gcctctgtgg ccggagaagt
    20941 cgccggggcc gcggccggtg gcggaccggc tgtgtctgca gggcatcctg tacgtgctct
    21001 acaacgacat agcctggcaa ctcctgcccc tggagtcggg gttcggctcc gggcagacct
    21061 gctggcgtcg cctggagcgg
//
