LOCUS       NZ_CP096281            28903 bp    DNA     linear   CON 08-JUN-2024
DEFINITION  Streptomyces sp. WAC00303 chromosome.
ACCESSION   NZ_CP096281
VERSION     NZ_CP096281.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. WAC00303
  ORGANISM  Streptomyces sp. WAC00303
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8548838)
  AUTHORS   Meyer,K.J., Tan,S. and Nodwell,J.R.
  TITLE     Genome Sequence of WAC00303 Direct Submission
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8548838)
  AUTHORS   Meyer,K.J., Tan,S. and Nodwell,J.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-APR-2022) Biochemistry, University of Toronto, 1 Kings
            College Circle 5207, Toronto, ON M5S 1A8, Canada
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 15-MAR-2022
            Assembly Method                   :: Flye v. 2.8.1
            Assembly Name                     :: WAC00303
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 58.0x
            Sequencing Technology :: Oxford Nanopore; Illumina NextSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023210535.1-RS_2024_06_08
            Annotation Date                   :: 06/08/2024 05:21:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,823
            CDSs (total)                      :: 7,731
            Genes (coding)                    :: 7,293
            CDSs (with protein)               :: 7,293
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 438
            CDSs (without protein)            :: 438
            Pseudo Genes (ambiguous residues) :: 0 of 438
            Pseudo Genes (frameshifted)       :: 228 of 438
            Pseudo Genes (incomplete)         :: 241 of 438
            Pseudo Genes (internal stop)      :: 26 of 438
            Pseudo Genes (multiple problems)  :: 54 of 438
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:23:54
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5418637
            Orig. end                         :: 5447540
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP096281.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Justin Nodwell, University
            of Toronto.
FEATURES             Location/Qualifiers
     region          1..28903
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="15"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..28903
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..28903
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:18903](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..18903
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    265..280
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.54"
                     /tool="antismash"
     gene            complement(1013..2320)
                     /gene="rfbH"
                     /locus_tag="MWG59_RS25215"
                     /old_locus_tag="MWG59_25215"
     CDS             complement(1013..2320)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rfbH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446985.1"
                     /locus_tag="MWG59_RS25215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25215"
                     /product="lipopolysaccharide biosynthesis protein RfbH"
                     /protein_id="WP_097932809.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 2.5e-96,
                     bitscore: 321.9, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDEHRTRVLEEARKHHQSVRDSGEFVPGTTEIWPSGAVLDEDDR
                     AALVEAALDLRIAAGPLSKRFESDFARLLKRRKAHLTNSGSSANLLALTAYTSPQLGER
                     RLLPGDEVITVAAGFPTTVNPILQNGLVPVFVDIELGTYNTTADRVAAAIGPKTRGIMI
                     AHALGNPFEVAEIAQLAADHSLVFVEDNCDAVGTTYRGRLTGTFGDISTVSFYPAHHLT
                     MGEGGIVTTSDLKVARIVESLRDWGRDCWCEPGHSDTCLKRFDHQLGALPAGYDHKYIF
                     SHVGYNLKSTDLQAALGLSQLRKLDGFIAARRHNWRRMREGLDGVRHLLLPEATPGSDP
                     SWFGFVMTVGPDAPFTCGELTGFLEKRKIGTRRLFAGNLTRQPAYHQQPHRVVGELTNS
                     DIVTERTFWTGVYPGLTDEMTDYVIASVREFVAGRR"
     gene            complement(2317..3309)
                     /gene="rfbB"
                     /locus_tag="MWG59_RS25220"
                     /old_locus_tag="MWG59_25220"
     CDS             complement(2317..3309)
                     /EC_number="4.2.1.46"
                     /GO_function="GO:0008460 - dTDP-glucose 4,6-dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009243 - O antigen biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (4-187). E-value: 1.4e-18.
                     Score: 58.9. Matches aSDomain:
                     nrpspksdomains_MWG59_RS25220_NAD_binding_4.1"
                     /codon_start=1
                     /gene="rfbB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446986.1"
                     /locus_tag="MWG59_RS25220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25220"
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="WP_248585921.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.2e-24, bitscore:
                     84.9, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 7.4e-18,
                     bitscore: 63.5, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 1.8e-16, bitscore:
                     58.9, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILVTGGAGFVGSHYVRTMLAQGYPGYEQADVTVLDKLSYAGNA
                     ENIPIGHPRLRLVKGDICDAPLLNELLPGHDAVVHFAAESHVDRSLDAPAVFTRTNVVG
                     TQTLLDACLNAGVERVVHISTDEVYGSIGEGSWHEESPLLPNSPYAASKAAADLTVRAY
                     WRTFGLDVSITRCSNTYGPYQHPEKAIPRFTTNLLEGEPIPLYGSGRNVRDWIHVDDHA
                     RAVQLVLTKGIAGGIYHVGGGHELTNIELAEQLLALCGADRSMIRHVTDRKGHDLRYSL
                     DGSKARTELGFTPRVGFDEGLAATVDWYRENTAWWKAAKGQAADTEDRS"
     aSDomain        complement(2749..3297)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MWG59_RS25220_NAD_binding_4.1"
                     /evalue="1.40E-18"
                     /label="MWG59_RS25220_NAD_binding_4.1"
                     /locus_tag="MWG59_RS25220"
                     /protein_end="187"
                     /protein_start="4"
                     /score="58.9"
                     /tool="antismash"
                     /translation="VTGGAGFVGSHYVRTMLAQGYPGYEQADVTVLDKLSYAGNAENIP
                     IGHPRLRLVKGDICDAPLLNELLPGHDAVVHFAAESHVDRSLDAPAVFTRTNVVGTQTL
                     LDACLNAGVERVVHISTDEVYGSIGEGSWHEESPLLPNSPYAASKAAADLTVRAYWRTF
                     GLDVSITRCSNTYGPYQHPE"
     gene            complement(3306..4373)
                     /locus_tag="MWG59_RS25225"
                     /old_locus_tag="MWG59_25225"
     CDS             complement(3306..4373)
                     /EC_number="2.7.7.24"
                     /GO_function="GO:0008879 - glucose-1-phosphate
                     thymidylyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0000271 - polysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446987.1"
                     /locus_tag="MWG59_RS25225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25225"
                     /product="glucose-1-phosphate thymidylyltransferase"
                     /protein_id="WP_097932807.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 2e-13, bitscore:
                     49.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKALILAGGLGTRLRPFTETMPKQLIPIANQPVLEHVLENLRALG
                     VREICVVVGAWGPDIAARIGDGSRFGARITYLTQQRPLGLAHCVAIARPFLGDDDFVMY
                     LGDNVVQDGIAGPAEEFRARRSDAHLVVARVADPRAFGVAELDALGRVRRLVEKPRLPL
                     SDLALIGVYFFRPAIHRAVAAIGPSARGELEITDAVQWLVDRGGPVTAGEYTGYWKDTG
                     RVEDVLDCNRRLLDSLARGVHGTVDAASRLTGPVHIAPGATVLRSVITGPVIVGPGSRV
                     EDCRIGPGTSIGGDCVLRGTELENSIVMDGAWVTERTGASDLLIGRSMRIGSDSPPVPP
                     PAELAANGARTGGTR"
     gene            complement(4398..5549)
                     /locus_tag="MWG59_RS25230"
                     /old_locus_tag="MWG59_25230"
     CDS             complement(4398..5549)
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_5 (32-160). E-value: 2.3e-12.
                     Score: 38.4. Matches aSDomain:
                     nrpspksdomains_MWG59_RS25230_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446988.1"
                     /locus_tag="MWG59_RS25230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25230"
                     /product="DegT/DnrJ/EryC1/StrS family aminotransferase"
                     /protein_id="WP_097932806.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 4.6e-89,
                     bitscore: 298.0, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.2e-06, bitscore:
                     26.8, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 4.3e-09, bitscore:
                     34.6, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVFQPSLGEAELLALSEVFASNWLGHGPRTDEFEARFADHIGV
                     EPDRMVFLNSGTAGLFLATELLDLGPGDEVVLPSVSFVAAANAIAATGARPVFCDVDPH
                     GLHPTVEHVERAMTPRTRAVIVLHYGGYPGEVAGIAALCRQRGVPLVEDAACAVASTAD
                     GRACGTFGDIALWSFDAMKVLVTGDGGMLYVRDPQLARRARVLAYHGLEQPSGFAHAKV
                     SERWWELDVRSFGRRVIGNDLTAALGTVQLGRLPANVARRREVATAYDSLLANTPGVRL
                     PPPLPEGHRSSYYFYWVQMDPLIRDRVAATLLAQDIYTTFKYPPLHRVPAYGDRATDLP
                     GTDLATDSTLLLPLHQALSDAEIRTVANALCEAVTHHLALAGA"
     aSDomain        complement(5070..5453)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MWG59_RS25230_Aminotran_5.1"
                     /evalue="2.30E-12"
                     /label="MWG59_RS25230_Aminotran_5.1"
                     /locus_tag="MWG59_RS25230"
                     /protein_end="160"
                     /protein_start="32"
                     /score="38.4"
                     /tool="antismash"
                     /translation="DEFEARFADHIGVEPDRMVFLNSGTAGLFLATELLDLGPGDEVVL
                     PSVSFVAAANAIAATGARPVFCDVDPHGLHPTVEHVERAMTPRTRAVIVLHYGGYPGEV
                     AGIAALCRQRGVPLVEDAACAVAS"
     gene            complement(5595..6899)
                     /locus_tag="MWG59_RS25235"
                     /old_locus_tag="MWG59_25235"
     CDS             complement(5595..6899)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF044385.1"
                     /locus_tag="MWG59_RS25235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25235"
                     /product="nucleotide disphospho-sugar-binding
                     domain-containing protein"
                     /protein_id="WP_097932805.1"
                     /sec_met_domain="MGT (E-value: 5.5e-117, bitscore: 390.1,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLFCTWPAAAHLYPSVPMAQALRDAGHEVRVISHPSLLDTINA
                     TGLTGVSLGDEETLPQPLGAGRPISPDTYADLVRITKSLELDSYERYVWTYYRDYMLPA
                     VRDFQPERAPAGEPQYALDALVDFCRSWRPDLVLWDPTMPAAGVAARVSGAAHARILWG
                     PDLFGWAHEQYTRCRKLSGDALLPEEPMTSSVRPMAERYGLPMTEELLFGQWTVNPVLE
                     RMRLPTVKRTVSMRWQAYTGPAVLPDWLREPPARPRVAITLGSSIRAWGRDSALLVNRV
                     LEMVDGLDIEAVATLDASQLAVADRIPDNVRTVDYLPLTELLPTCSAVIHHGGHGSFGA
                     ALVNRIPQFVVMDPGYPMEAPITGRFLSESGVGTGVRVDRHTGAELRAGLSRLLTAPSF
                     RDAAAELYTDLLTAPEPSEIIPVLERLTRHHQSRD"
     gene            complement(6922..7563)
                     /locus_tag="MWG59_RS25240"
                     /old_locus_tag="MWG59_25240"
     CDS             complement(6922..7563)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446992.1"
                     /locus_tag="MWG59_RS25240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25240"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_248585922.1"
                     /transl_table=11
                     /translation="MSEPSDRIAGVGARADSGVEVFERHYAGEPGAGWEIQRPQTVLVR
                     LAEEGALRGRVLDVGCGSGDNALLAAEHGLETTGVDAAPSAITLAVGKARERGLKARFL
                     EWDALDLAALGQQFDTLIDVGLFHCFAPEDRPLVARSMASVVPPGGRCFLMCFSDRQPG
                     TWGPRRVPEQAVRESFTGAGWRVDTLEAAELDVAFSPGVAQAWFAAMTRL"
     gene            complement(7806..8543)
                     /locus_tag="MWG59_RS25245"
                     /old_locus_tag="MWG59_25245"
     CDS             complement(7806..8543)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018891726.1"
                     /locus_tag="MWG59_RS25245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25245"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_306472957.1"
                     /transl_table=11
                     /translation="MVTQQRPSTVYSTEHAEIYDFIHAARGRDWSAEADGITRLIRERC
                     PEAGSLLDVACGTGAHLERFAEHFGTVAGVELSPEMRRTATRRVPAARVHEGDMRQFEL
                     GRTFDAVLCMCFSLGYMSTVEELRRSAATLVRHLAPGGVLVAEPWWFPEQFIDGFISAS
                     LAQEEGRAVSRLSHSVRDGRISRMTVRYTVAETTGIREFTEYETYSLFTQEEYLDAFRQ
                     AGCEMEFLSDWPNGRGLFIGVRA"
     misc_feature    complement(8764..8780)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.74"
                     /tool="antismash"
     misc_feature    complement(8850..8863)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.81"
                     /tool="antismash"
     misc_feature    complement(8858..8873)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.65"
                     /tool="antismash"
     gene            8859..10004
                     /locus_tag="MWG59_RS25250"
                     /old_locus_tag="MWG59_25250"
     CDS             8859..10004
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451957.1"
                     /locus_tag="MWG59_RS25250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25250"
                     /product="hypothetical protein"
                     /protein_id="WP_248585923.1"
                     /transl_table=11
                     /translation="MITDTAAAGPDMSEAAGVRLYSRVPITPRWLAKTVLPVSRRLRED
                     HRAALLHLRRGWLHGPHIDIVARSVPGRPALDWAGIAAALDAGPAEGPAVTDEETYLAQ
                     AREMGRLEGVAPPYLPMREHGATEALSLSSVETWPQPLQDLRELALDQLDRPLTTTVEQ
                     LAGEPREAPVRIMEAFAALAAAHQHGAGNGAFSMRSHAEAFFAWAAARKDPRPAFAQRL
                     AADAPRLRPVVERALSGTPDHGTSAWARAFAYSMGAFDATVAQGRLTLDDVDGLGAGFD
                     LATMGPPGGDGRVSTEPSAFHRTMEESGVIASPPQWFASYRLLVNLFYQQLPLLGVPPM
                     HRYYFCFAVAELVDDVLGSSWQDRLEQTRQEMAQATAGAAE"
     gene            10001..12544
                     /locus_tag="MWG59_RS25255"
                     /old_locus_tag="MWG59_25255"
     CDS             10001..12544
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_N"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451956.1"
                     /locus_tag="MWG59_RS25255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25255"
                     /product="hypothetical protein"
                     /protein_id="WP_248585924.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.3e-11, bitscore:
                     40.1, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDTAEPLWMLRLNPLRRRRLADPGLLAALRTLDGATTEVRELAE
                     RCSEALYELIGATTDREARGQLIGLRRAIHNDTAPRPALRVDHPLVDRWWEARQRREAL
                     AADVVGCYPRAVDAERGTLAGLLGDESLRHSMTLVAPEAAAGAGRYRAAVAATEPVPTR
                     LRKSERGLVQYVTRAMIRTSPMARFTAIGLAVPGPDGPGPDAPEFGRVVPFQGLDRVML
                     DYVLGGLHTSGGDLTPDTLIQLPPTSDLSAEGDLLYFLQPGADGGVRRLSAKVSGAVGL
                     LVAAVAVGPRRAADVVADFAARSGCTPELAWQALARAVGAGILCTRSRPEDGAADFPDL
                     LDPAGLTVPETARRLLEQTGAELRGLADDSADERPEALSRLRDTLVALSREAGRPAQIL
                     IEEDAVLEDVRVSTADWRSQLDDLAAGVALLSVFDWMHDIRALLSAVFVERFGAGAEVP
                     LTDHADYLSAETYRRAYRLPENAPPGELGPADRSLDRLYALRANIVDTAIAAIDQAAAT
                     GEAVGWSASQALDLTTGLPDRFRTGDLRYGVLTQTWRRQLLFNEAYAGHGMLYGRFLGP
                     DRALGGRALPHFREQLRARYAEQDGRLVEDPGLHRLNVNAHPPVLPDRLGPDDWFRLRL
                     RHDPDTDALGILDPDGRPLHMLSLGTGHPERLPAPLRLANWLYSGGVLREPFVAIWHAE
                     RQWDGDRTRACPRFQVGSAMLARRRWYGGRELDEAVAAGPAEHDRLLALARWRNRHGVP
                     EEVVLKPPPGDGSGEGQATGAGQAAGEGRKKKPQYVDLASALSVRVLPRMRERGDAAYV
                     EEALPRVADSPHALEWIVDIGRAPDGPFQYGGKTR"
     aSDomain        12541..12786
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_MWG59_RS25260_Thiopeptide_F_RRE.1"
                     /evalue="6.70E-11"
                     /identifier="RREFam004.1"
                     /label="MWG59_RS25260"
                     /locus_tag="MWG59_RS25260"
                     /protein_end="82"
                     /protein_start="0"
                     /score="33.0"
                     /tool="antismash"
                     /translation="MTLRARPHLHYAPVSEGVYFNGPRTQFVISGPQLLYRVADTCVPL
                     LEAGTTEDELVTALGSERARPVVRRIVDELRARDLLL"
     gene            12541..14364
                     /locus_tag="MWG59_RS25260"
                     /old_locus_tag="MWG59_25260"
     CDS             12541..14364
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MWG59_RS25260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MWG59_25260"
                     /product="hypothetical protein"
                     /protein_id="WP_248585925.1"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 1.9e-08,
                     bitscore: 33.0, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLRARPHLHYAPVSEGVYFNGPRTQFVISGPQLLYRVADTCVPL
                     LEAGTTEDELVTALGSERARPVVRRIVDELRARDLLLDLGALTVPEPSAEIRARYPEAL
                     AHLETECADPYAVFQRLRATEVLLCGPADAVLPAARGLHRAGITGLTLATPDFEAAAAT
                     TSRLGLRLLPLSDSASLPDPGDLPVPPDAALYCPGADDGVTPEALTALLPEAALLVPVR
                     WDGLVAAVGPAAPGGASLPGSAALIGRAARWAAADADAAAPAPHPTAEALAGALAGQLL
                     FDTLAGIAQPGEAHVLHGEELTADQVRVAAPGTAYGEAAERRFLTAAPVSGAEPVPPPT
                     PDEAVEAVTALTGRWTGPFALLGGEELPQMPLALREMADRDGGAGSVVAWAEEQRTATV
                     AVALAALRAACPTPGAAAAGLTEEHWLLDGALRLMADEAVPYATRAVGAVEARSAPLLR
                     MLEEEGMPDPALTLLRHPGLDWTLAEVRTSGGPQPWTGRSWGRDETEAVHRALATALAR
                     HQTHGVPGAGPLAEGVHTDALLFADASAQAALRKQIADAAAAAGLRYEGAPRRPDPVTG
                     ALPLWSGGVRAVPLDGEPQAAEESAEETAHG"
     gene            14357..16288
                     /locus_tag="MWG59_RS25265"
                     /old_locus_tag="MWG59_25265"
     CDS             14357..16288
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451953.1"
                     /locus_tag="MWG59_RS25265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25265"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_097936899.1"
                     /sec_met_domain="YcaO (E-value: 9.7e-66, bitscore: 221.5,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 2.8e-65, bitscore:
                     219.4, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAENATTVACAPALADAEGTDWRAVLEPLGASGDGTVGANLGWDL
                     DWEREQLRSADGREHLSVRVYGDEVLVGPRWVPGTDSGCAGCAELRSRLVIDHPLTDDL
                     TRPTSRVAPRRPFLPELTRAALARLAVRPLGPGELYAVGSRGTRTHRIPRHFACPLCAP
                     EIPERPVGRPPQPLALRSRPAASDNPGRAAAGAGLVRPGALRSRLVDPRFGPVLAQQRE
                     LLAPFAMSMALQPDAVALGYARETTFAKADPIAILEVYERLSGFPHQAPLVEGVSYAEL
                     VRTEGGAELAVRPAAFGEYTEEQAARPTARIERVTDETPMDWAWGHDLADGRPRLVPAE
                     LAFFQYDYRYGRDQRAARRHGAAPRRHLYQESSSGCAVGSCLEEAALYSLLELAERDAF
                     LISFHRALPLPEITHSSITDPVVRGLLATAASRGFRVHLLRATQDIDLPVVWAMAVNTR
                     APFPATFSAAGSGIDPVSAVRGALWEVVQMATERMDWERSEAEPMLADPWLVDEMDDHL
                     RLYALPEMKERVTSVLGGPETSLSEAFAGWPDRLEQVAGGDVRGALDYVRGRYAEAGLD
                     RIVLVDSTTRDHADIGLAAAKAVVPGIVPMCFGQAQQRVAGLPRLEAALAGTPSGELSP
                     PYDPHAFP"
     gene            16379..17863
                     /locus_tag="MWG59_RS25270"
                     /old_locus_tag="MWG59_25270"
     CDS             16379..17863
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018553604.1"
                     /locus_tag="MWG59_RS25270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25270"
                     /product="nitroreductase family protein"
                     /protein_id="WP_248585926.1"
                     /sec_met_domain="PF00881 (E-value: 1.7e-05, bitscore: 23.8,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTSDRGGPASPIPDDADVMSRDMRWFTYATGLGVRVEAEAVPE
                     PRPDTEVAPALPEAALGDRTPLPRGTTELLERAPYPHGRVGSPRESADALGHALVAGFG
                     LQRREPENPFNDHRPYPSVRAKFPVQVLVRDGRHRRVLDLYRHALTGVGRQDGAAGPLE
                     VALAGRYTRLPDSYRWFRSSLIGLELGVNLRQLCLGMELFGLSGRLRLPDRNATGLLTD
                     FGLTPEAEWSLPLTVALEDGAPPVAAAPAERAADPVLDGILTVNRAQDFTGPAAPLGPS
                     VPAGLPRHGALSWAEVLWRRSAGRMPRGMYGMTGRRRPVPERTLREAVSWLSVPPPGPQ
                     LAAAWEELRVTAVFQGIDGHADGVWHLRDGRPTLHRARPGAAAELETHYGYPVTPYAGG
                     DVRHASAVWFLSAHPRRLVDRLGPGGFTAAQYAAGWAAQGISLAAAATGLYARPARAFQ
                     EVPTRQLLGLDPDEMIVCAAITGTPRFEGLLCDLRL"
     gene            17878..18903
                     /locus_tag="MWG59_RS25275"
                     /old_locus_tag="MWG59_25275"
     CDS             17878..18903
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547685.1"
                     /locus_tag="MWG59_RS25275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25275"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_097936901.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.7e-39, bitscore:
                     135.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTSETARAGGGAGPGGPDTVWRTWHLHVPSGDRSAHDRVVVDT
                     VGPVLRTLPGRPWFFLRYWHGGPHIRLRIGDVTDDQAASAERLLAERLVDAGRLREGET
                     AMDPAAYARTAAAMTTAGDQPSHQEVTGMLEPGVHRFAYHPEHERYGGRELMPESERLF
                     ELSSRLVLAFLRREPSTGARALLALRATVCAARALGDDPAEEAAFYDHGLRAWRTWAAG
                     YGYTERQLDELYRTARPTDELRAKATGGDTGGPLAPWQAALTGLSDRIRRQTPLHPAQV
                     TISHVHMLHNRLGLRTVEEYQTYARLARLFPVRPAPEGAPPPDHSGPAQSSAVPSTEEH
                     R"
     gene            18900..19817
                     /locus_tag="MWG59_RS25280"
                     /old_locus_tag="MWG59_25280"
     CDS             18900..19817
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451944.1"
                     /locus_tag="MWG59_RS25280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25280"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_050360649.1"
                     /transl_table=11
                     /translation="MSTSPTTATARAGAPPTPAVVARAIGVTRHYGDTVALDNVDFTVR
                     EGEFIGLLGPNGAGKTTLLNSLLGLRKPTSGRIELFGGSPTNPASRRFIGVTPQESGVP
                     PTLRVAEAVDFVAAHFKETEDRDELLERFDLTKEARRQAGGLSGGQKRRLALALAFVGR
                     PRLVILDEPTTGLDVESRRMLWDRIREFHEGGGTVLLTTHYLEEIEALAKRVVVIAQGR
                     IRADDSVGAIRGMAHMQRVSMNAGPLPDLPGVISEERTEERVELMTHDADQLVRALVRQ
                     GVEFSGLAVQQATLEEAFLVISQS"
     gene            19851..20591
                     /locus_tag="MWG59_RS25285"
                     /old_locus_tag="MWG59_25285"
     CDS             19851..20591
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451942.1"
                     /locus_tag="MWG59_RS25285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25285"
                     /product="ABC transporter permease"
                     /protein_id="WP_097936902.1"
                     /transl_table=11
                     /translation="MSSLTLVHARYQLVELSRIPMAIIGAAFFPAASLFFFVVPNTKDD
                     PAGATLATASMVVFAAMISNLFGHGTGVAEDRSQPWDPYTRTLPIGPAVRFGSRIITGL
                     AMMLFSMFPVVIVAAFFTPATISPVRFLLAIGVVIIVSVPFTMMGLAIGYLLSTKAAIA
                     TVQLVFLPLAFAGGLLGGPGEAPGFIETIAPFVPTRGSAELMWATVGDFEINPVSIVSL
                     VVWTVGLAALAFYAYQRDEGRRYH"
     gene            complement(20773..22419)
                     /locus_tag="MWG59_RS25290"
                     /old_locus_tag="MWG59_25290"
     CDS             complement(20773..22419)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019074884.1"
                     /locus_tag="MWG59_RS25290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25290"
                     /product="bifunctional
                     3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid
                     hydroxylase"
                     /protein_id="WP_248585927.1"
                     /transl_table=11
                     /translation="MNGISGSRGRSAGAPEADVLVVGYGPVGQVLSILLAQHGWRVVVV
                     ERHPEPYSLPRAVAFDAEAARTLDAVGVSGRIGDITEPSQDYVVSDAAGRQLLRIGLGG
                     SDGPGRPDSTSVYQPGLEAALAARGEELPTLRVIRGLRAVELTESGSGAELVAEDERSG
                     ERRTFTASWVVGCDGAGSFVRHSLGVGWADSGFALDWLACDVVPHRPEDFPPSNLQVAD
                     PARPRVAVSCGPGRRRWEFMRMPGEDRAEFGTEENAWRLLSMFSARPDNATLTRHATYT
                     FRARNAEHWRRGRVLLAGDAAHQMPPFAGQGMCSGFRDAANLAWKLDLVLGGRAGEALL
                     DSYEQERRAHVQHAIDLSVRLGRLICLTDPAAAADRDRAMTARPAGPARPGGPARSASP
                     LGEHLAKGFLADGGPPAGELMGQVRLSGPDGPGPADSVLGPGFVLLCRENLADALSPAA
                     LETLRPVHGRVVTVLRADAGSAPGPDTVLDTDGRCLPWLESIPAGAVLIRPDRYLFGAA
                     PDADGLAALLTEFGRRLRPATGGPGAAAGSA"
     misc_feature    22546..22561
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.88"
                     /tool="antismash"
     misc_feature    complement(22594..22608)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.99"
                     /tool="antismash"
     gene            22662..22826
                     /locus_tag="MWG59_RS25295"
                     /old_locus_tag="MWG59_25295"
     CDS             22662..22826
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036314.1"
                     /locus_tag="MWG59_RS25295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25295"
                     /product="thiazolylpeptide-type bacteriocin"
                     /protein_id="WP_073740161.1"
                     /transl_table=11
                     /translation="MSMAIEAMNADALFDSFDIEELDTMEVADGVALPEMGASTGNTMC
                     CSSSSSSCC"
     misc_feature    22924..22939
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.47"
                     /tool="antismash"
     misc_feature    complement(22926..22939)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.12"
                     /tool="antismash"
     misc_feature    22978..22992
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.51"
                     /tool="antismash"
     misc_feature    22980..22991
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.18"
                     /tool="antismash"
     gene            23039..23203
                     /locus_tag="MWG59_RS25300"
                     /old_locus_tag="MWG59_25300"
     CDS             23039..23203
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547678.1"
                     /locus_tag="MWG59_RS25300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25300"
                     /product="thiazolylpeptide-type bacteriocin"
                     /protein_id="WP_073740160.1"
                     /transl_table=11
                     /translation="MSKILESVDADAMFDSFDIEELGTMELADGVALPEMGASKGDFTC
                     CSSSSSSCC"
     misc_feature    23308..23323
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.88"
                     /tool="antismash"
     misc_feature    complement(23358..23374)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.57"
                     /tool="antismash"
     misc_feature    23359..23373
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.51"
                     /tool="antismash"
     misc_feature    23361..23372
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.18"
                     /tool="antismash"
     misc_feature    23536..23552
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.23"
                     /tool="antismash"
     gene            23600..23770
                     /locus_tag="MWG59_RS25305"
                     /old_locus_tag="MWG59_25305"
     CDS             23600..23770
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036314.1"
                     /locus_tag="MWG59_RS25305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25305"
                     /product="thiazolylpeptide-type bacteriocin"
                     /protein_id="WP_097933881.1"
                     /transl_table=11
                     /translation="MRSTLESVDADAMFDSFDIEELDTMEIADGVALPEMAASSLPVTC
                     CSSSSSSCCCC"
     misc_feature    complement(23873..23886)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.19"
                     /tool="antismash"
     gene            23886..25532
                     /locus_tag="MWG59_RS25310"
                     /old_locus_tag="MWG59_25310"
     CDS             23886..25532
                     /NRPS_PKS="Domain: AMP-binding (23-440). E-value: 1.6e-68.
                     Score: 223.1. Matches aSDomain:
                     nrpspksdomains_MWG59_RS25310_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.4"
                     /locus_tag="MWG59_RS25310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25310"
                     /product="fatty acid--CoA ligase family protein"
                     /protein_id="WP_248585928.1"
                     /sec_met_domain="AMP-binding (E-value: 1.2e-69, bitscore:
                     233.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFPIDVPDSWAGHEHYARRVLWRLARQPSLPTLYFQGRWLNGAT
                     LADAVRATAVGLRRAGLTPGGTVAVLTEPNHPAMLIGRYAAHLLGAAVVQVRSANPRSD
                     AFPLPAATQARILDGTGTSVILVDAPQLERARALLSLTEGRPRLLGYGVGAADCPDALS
                     CRDEPLGELPTHSPDRRALVAFTSGSSGTPKSIDQTFGVWDSTVRSAASGEPDERRVFL
                     AVTPLSHTIGAMADSVLAAGGQVLLHQDFDAPRVLRAFEDHSVTDTYLAVPHLYRLTEL
                     LADSPGHEQGPGPGPVGDALWSLRRVVYSGTPAAPHRIAEALRVFGPVLVQLYGTTEAG
                     GISNLSPFDHLEPELLGSVGRPLPWVEVEVRDPGTGDPVPRGEAGEIWVRASTVMDGYP
                     NDPEQTARVLRDGWLDTGDLGHWDRYGYLRLTGRSGQVIKSGGLKIYPAAVERALLSHP
                     AVRHAAVHGVRDPDRTEYVHAAVVFRAGRTSSAEELRTHVGELLSPLHAPAEITFWDSM
                     PLNERGKPDLACLRSGNGRQAYDGAPPKGTP"
     aSDomain        23955..25205
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MWG59_RS25310_AMP-binding.1"
                     /evalue="1.60E-68"
                     /label="MWG59_RS25310_AMP-binding.1"
                     /locus_tag="MWG59_RS25310"
                     /protein_end="440"
                     /protein_start="23"
                     /score="223.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RLARQPSLPTLYFQGRWLNGATLADAVRATAVGLRRAGLTPGGTV
                     AVLTEPNHPAMLIGRYAAHLLGAAVVQVRSANPRSDAFPLPAATQARILDGTGTSVILV
                     DAPQLERARALLSLTEGRPRLLGYGVGAADCPDALSCRDEPLGELPTHSPDRRALVAFT
                     SGSSGTPKSIDQTFGVWDSTVRSAASGEPDERRVFLAVTPLSHTIGAMADSVLAAGGQV
                     LLHQDFDAPRVLRAFEDHSVTDTYLAVPHLYRLTELLADSPGHEQGPGPGPVGDALWSL
                     RRVVYSGTPAAPHRIAEALRVFGPVLVQLYGTTEAGGISNLSPFDHLEPELLGSVGRPL
                     PWVEVEVRDPGTGDPVPRGEAGEIWVRASTVMDGYPNDPEQTARVLRDGWLDTGDLGHW
                     DRYGYLRLTGRSGQVIKS"
     CDS_motif       24426..24470
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MWG59_RS25310_0001"
                     /evalue="3.70E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="MWG59_RS25310"
                     /protein_end="195"
                     /protein_start="180"
                     /score="13.5"
                     /tool="antismash"
                     /translation="ALVAFTSGSSGTPKS"
     CDS_motif       25023..25106
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MWG59_RS25310_0002"
                     /evalue="8.60E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="MWG59_RS25310"
                     /protein_end="407"
                     /protein_start="379"
                     /score="24.5"
                     /tool="antismash"
                     /translation="PRGEAGEIWVRASTVMDGYPNDPEQTAR"
     gene            25529..26371
                     /locus_tag="MWG59_RS25315"
                     /old_locus_tag="MWG59_25315"
     CDS             25529..26371
                     /GO_function="GO:0004332 - fructose-bisphosphate aldolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007455580.1"
                     /locus_tag="MWG59_RS25315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25315"
                     /product="2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate
                     synthase"
                     /protein_id="WP_050360644.1"
                     /transl_table=11
                     /translation="MTTHQHFGRAVRLRRLFHHDPQRLMIVPLDHSLSDGPVVPRGSSI
                     DRLAGQLSGAGVDAIVVHKGSVRHIDHSRLATMSLILHLNASTAHAPDPDAKHLVTGVE
                     AALRLGADAVSVHINMGSREEARQLADLGAVADQCDRWNLPLLAMMYPRGPKITDPADP
                     ELVAHAVTLAADLGADLVKAPCLRTRAEMRDLTAACPIPLICAGGPQRDTEDEVLAFAR
                     EAVAGGAAGVAMGRNIFQSPDPGAMAARVAGVVHNRPGGTLGHIEEGHGSELRETVLA"
     gene            26343..27452
                     /locus_tag="MWG59_RS25320"
                     /old_locus_tag="MWG59_25320"
     CDS             26343..27452
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547674.1"
                     /locus_tag="MWG59_RS25320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25320"
                     /product="3-dehydroquinate synthase II family protein"
                     /protein_id="WP_248585929.1"
                     /transl_table=11
                     /translation="MSSEKLCWLDIRSAGKARQAIVEEALHQRIDAIVAADPADLEGLP
                     PTVTKVLMPPPGKQPASYGSAGVVILAGDASARAQAAEAAPDVEFGRLVEITDAESLDA
                     AIEAARTERWSVLEFRDPTKIPLEIVIAAAADADGAIITMAKNTEEAAVVFGCLQLGSD
                     GVLMPGRSVGDATALKATAAGGTGELLLVELEVTAVAHIGMGERACVDTCSYLGKDEGI
                     LVGSHSKGMILCVSETHPLPYMPTRPFRVNAGAIHSYTLADEGRTRYLSELRAGSKVMA
                     VDTKGRTRTVAVGRVKIETRPLISIDAVAAGGQEVNLILQDDWHVRVLGPGDAVLNSTE
                     LRPGDRVLGHLPTADRHVGYPIDEFCHEQ"
     gene            27442..28650
                     /locus_tag="MWG59_RS25325"
                     /old_locus_tag="MWG59_25325"
     CDS             27442..28650
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007455576.1"
                     /locus_tag="MWG59_RS25325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_25325"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_248585930.1"
                     /transl_table=11
                     /translation="MSSSAPAPGIAVIGAGIGGLTLAAALARLGIGCRVFERAEQPAEA
                     GAGVQLGPNAVRLLRRLGLSDSLRQHGVRPLSRDLLRWEDGRLLARTELGEACEKLFGA
                     PYVTVHRADLHRALRDLVGPVVRTGHRLTGLAEEPGAVVLRFADGSEHRSELAVGADGI
                     RSVVREHLAADAPVFSGRRIYRGLVPVERVPELADEPRVQVWLGPGRHCVCYPVSGGRL
                     ISFAATTGGTALPGESWTALGDRGEAAEAFQGWHPTVTRLLGAGGGIGCWALHDREPLA
                     RWSSDALTLLGDAAHPMLPFAAQGANQAIEDAFALAATLALSRGDIPEALRRYEELRIP
                     RTDRLQRSARSVAVGSHLPDGPLQRARDAELASGSALEGLRWVYGHDALAAAARWTAER
                     QKA"
ORIGIN
        1 agcggctggg tccagctgcc cacctcccgg ccgtccgcct cgaccgcgac cgcgaccacg
       61 cggaagtggc ggtcgtcggt acggcggatg gcctgttcgt cccggagcca gccccgcacc
      121 cgggcgagcc gcacgggctc ggccgtgagc cgggggcggg aacgggcggc accgagccag
      181 gacgacacct cggcgtcggt gtgcagggac ggcccttgcc ctccgggggt cggcaggcag
      241 gccagtacgg tcctggtgtc catgttgacc acgttgtcca gccgcaggag ctcgccgatc
      301 tggcccaggg tcagccagcg gaagtccggt tcggcggcgg ggtcctcggc gacctcgtcg
      361 gccgtctcca ccacgacgtt gcggttcgac ttgtgcagga accactcgcc gtgctcggac
      421 tgcagtgtgt cggtcagtgg ccgggcgcgg ccgggctcgg tgaagaactc caggaaccgc
      481 acgcccgagc cgccgtgcac ccgctggtag ttgctgcggg tggcctgcac ggtcggtgac
      541 agctggagca tgccccggtt gcccggttcc atcttggcct ggaccaggaa gtggagtacg
      601 ccgtcgaact ccttggcgag caggccgagt acgccgacct ccggctgcct catgacaggc
      661 tgctcccacg gagcgccggg ccggtccgcg ctgtgcacgc gcatgccctc gacggtgaag
      721 aagcgcccgc tgcggtggac caggttcccg gtgtcctcct ggaacgacca gccgtccagc
      781 tccgcgaacg ggatgcgccg gatccgtgtg cggtgggccc tgcggcgttc cgccagccat
      841 gcgacgatct cgcccgtcgt ggtccgggct ccggtggccg ggccggtggc ggccacggag
      901 cgggcgatcc tggccgcctg cccgtcctgc ccgtcctcct cgctcagccc gtgatgcccg
      961 cgctgcccgc ccggtccggt cgccgcgccg tgcggccggg agctgtcgac tctcaccgac
     1021 ggcctgccac gaactcccgt accgaggcga tgacgtagtc ggtcatctcg tcggtgaggc
     1081 ccgggtagac cccggtccag aacgtgcgct ccgtgacgat gtcgctgttg gtcagttcgc
     1141 cgacgacacg gtggggctgc tggtgatagg cgggctgacg ggtgaggttg cccgcgaaca
     1201 ggcggcgcgt accgatcttc cgcttctcca ggaacccggt cagctctccg cacgtgaacg
     1261 gggcatcggg ccccaccgtc atcacgaatc cgaaccagct cgggtcgctg ccgggagtcg
     1321 cctccggcag caggagatgg cgtacgccgt ccaggccctc acgcattcgc cgccagttgt
     1381 ggcggcgcgc cgcgatgaaa ccgtccagct tccgcaactg tgacaggccg agcgccgcct
     1441 gcaggtccgt cgacttcagg ttgtagccga cgtgggagaa gatgtacttg tggtcgtagc
     1501 cggcgggcaa cgcgccgagc tggtggtcga agcgcttcag gcaggtgtcg ctgtggcccg
     1561 gttcgcacca gcagtcccgc ccccagtccc gcagtgattc gacgatccgc gcgaccttga
     1621 ggtccgaggt cgtcacgatg ccgccctcgc ccatcgtcag atggtgcgcg ggatagaagc
     1681 tcaccgtgct gatgtcgccg aacgtcccgg tcagccgccc ccggtaggtg gtgccgaccg
     1741 cgtcgcagtt gtcctcgacg aataccaggc tgtggtccgc ggcgagttgg gcgatctccg
     1801 ccacctcgaa cgggttgccc agggcgtgcg cgatcatgat gccgcgggtc ttgggcccga
     1861 tggccgcggc gacgcggtcg gcggtggtgt tgtacgtgcc gagctcgatg tcgacgaaga
     1921 ccggcaccag cccgttctgc aggatcgggt tcaccgtggt gggaaacccc gcggcgaccg
     1981 tgatgacctc gtcgcccggc agcagccgcc gttcgcccag ctgcggggag gtgtaggcgg
     2041 tgagcgccag caggttggcc gacgaaccgg agttcgtcag atgggccttg cggcgcttca
     2101 gcagccgcgc gaagtccgac tcgaagcgct tggagagcgg cccggcggcg atccgcagat
     2161 ccagggcggc ctccaccagc gccgcgcggt cgtcctcgtc caggacggcg ccggacggcc
     2221 agatctccgt ggtgcccggc acgaactccc cggaatcacg cacgctctgg tggtgcttcc
     2281 gcgcctcttc caggacccgt gtcctgtgct cgtcgttcac gaccggtcct ccgtgtccgc
     2341 tgcctggccc ttcgcggcct tccaccacgc cgtgttctcc cggtaccagt cgacggtggc
     2401 ggccagtcct tcgtcgaagc cgacccgtgg cgtgaacccc agctcggtac gggctttgga
     2461 cccgtccagc gagtagcgca ggtcgtgtcc cttgcggtcg gtcacatgcc ggatcatgga
     2521 ccggtccgcg ccgcacaggg cgagcagctg ctccgccagc tcgatgttgg tcagctcgtg
     2581 gccgccgccc acgtggtaga tgccgcccgc gattcccttg gtcagcacga gctggacggc
     2641 ccgcgcgtgg tcgtccacat ggatccagtc gcgcacgttc cgcccggagc cgtacagcgg
     2701 gatcggctcg ccctccagga ggttggtggt gaagcgcggg atggccttct ccgggtgctg
     2761 gtacgggccg tacgtgttgg agcagcgcgt gatcgacaca tcgagcccga aggtccgcca
     2821 gtaggcgcgt acggtcaggt ccgccgccgc cttggaggcc gcgtaggggg agttgggcag
     2881 aagcggcgac tcctcgtgcc aggatccctc gccgatgctg ccgtacacct cgtccgtgga
     2941 gatgtgcacc acccgctcca ccccggcgtt caggcaggcg tccaggaggg tctgggtgcc
     3001 caccacgttc gtccgggtga agacggcggg ggcgtccagg gacctgtcga cgtgcgactc
     3061 ggccgcgaag tgcaccacgg cgtcgtggcc gggcagcagt tcgttcagca gaggcgcgtc
     3121 gcagatgtca cccttgacga gacgcagccg ggggtggccg atcggaatgt tctcggcgtt
     3181 gcccgcgtag ctcagcttgt ccagcacggt gacgtcggcc tgctcgtagc ccgggtaccc
     3241 ctgggccagc atcgtccgga cgtagtgcga gccgacgaac ccggccccgc cggtgaccag
     3301 aatcctcatc gggttcctcc tgtacgcgcg ccgttcgcag ccagttccgc gggcggtggc
     3361 accgggggcg agtcggagcc gatccgcatc gagcggccga tgagcaggtc gctcgcaccg
     3421 gtccgttccg tcacccacgc gccgtccatc acgatggagt tctccagctc ggtgccgcgc
     3481 agtacgcagt cgccgccgat cgacgtgccc ggtccgatac ggcagtcctc gacgcgggag
     3541 ccggggccga cgatcaccgg cccggtgatg acggagcgca gcacggtggc gcccggggcg
     3601 atgtgcaccg ggccggtcag gcggctggcg gcgtcgaccg ttccgtggac gccccgggcc
     3661 aggctgtcca gcagacgccg gttgcagtcc agcacgtcct ccacgcgtcc ggtgtccttc
     3721 cagtagccgg tgtactcgcc ggccgtgacc gggcctcccc ggtcgaccag ccactggacg
     3781 gcgtcggtga tctccagctc gccgcgtgcg ctcgggccga tcgcggcgac cgcccggtgg
     3841 atggcggggc ggaagaagta gacgccgatg agcgccaggt cgctgagcgg caggcgcggc
     3901 ttctccacca gccgtcggac ccggccgagg gcgtccagct cggccacccc gaaggcgcgg
     3961 gggtcggcga ccctggccac caccaggtgc gcgtcggacc ggcgggcccg gaactcctcg
     4021 gccggccccg ctatgccgtc ctgcacgacg ttgtcgccga ggtacatcac gaagtcgtcg
     4081 tcgccgagga acggacgggc gatggccacg cagtgcgcca gccccagcgg ccgctgctgc
     4141 gtgaggtagg tgatccgggc gccgaaccgc gatccgtcgc cgatccgtgc cgcgatgtcg
     4201 ggtccccacg cgccgacgac cacgcagatc tcccgcaccc ccagcgcgcg gaggttctcc
     4261 agcacgtgtt cgagtacggg ctggttggcg atgggtatca gctgtttggg catggtctcg
     4321 gtgaacggcc gcagccgcgt cccgagcccc ccggcgagta tcagcgcctt catgggcgtt
     4381 cctcccgtcg gcgtgcgtca ggccccggcc agggccaggt ggtgggtgac ggcttcgcac
     4441 agcgcgttcg ccaccgtccg gatctccgcg tcgctcagcg cctggtggag ggggagcagg
     4501 agtgtgctgt cggtggccag gtcggtcccg ggcaggtcgg tggcccggtc gccgtaggcg
     4561 ggcacccggt gcagcggcgg gtacttgaag gtggtgtaga tgtcctgggc cagcaacgtg
     4621 gccgcgaccc ggtcacggat gagcggatcc atctggaccc agtagaagta gtacgaggag
     4681 cggtgcccct cgggcagcgg gggcggcagg cgtacgccgg gggtgttcgc gagcaggctg
     4741 tcgtaggcgg tcgccacctc gcgccgccgg gcgacgttgg cgggcagtcg gccgagctgc
     4801 accgtgccga gcgcggcggt caggtcgttg cctatgacgc ggcggccgaa gctccgtacg
     4861 tcgagttccc accaccgctc ggacaccttc gcgtgggcga agccgctggg ctgctccaga
     4921 ccgtggtagg cgaggacccg ggcgcggcgc gcgagctgcg gatcgcggac gtacagcatg
     4981 ccgccgtccc cggtcaccag cactttcatc gcgtcgaagc tccagagggc gatgtcgccg
     5041 aaggtgccgc acgccctgcc gtcggccgtg gaggccacgg cgcaggccgc gtcctcgacg
     5101 agggggaccc cccgctgccg gcacagggcc gcgatccccg cgacctcccc ggggtagccg
     5161 ccgtagtgca gcacgatgac ggccctggta cggggtgtca tggcacgctc gacgtgctcc
     5221 acggtcgggt ggagaccgtg gggatcgacg tcgcagaaga cggggcgcgc gccggtcgcg
     5281 gcgatggcgt tggcagcggc cacgaagctc acggacggca gtaccacctc gtcgccgggg
     5341 cccagatcga gcagctcggt ggcgaggaag agcccggccg tgccggagtt gaggaagacc
     5401 atccggtccg gctcgacccc gatgtggtcc gcgaagcgtg cttcgaactc gtcggtgcgg
     5461 ggtccgtggc ccagccagtt cgaagcgaag acctcggaca gggcgaggag ttccgcctcg
     5521 cccaggctcg gctggaagac gttgatcacg cggtggctcc ctggcgcggt ggggacgatg
     5581 ggaagggggc gggttcagtc ccggctctgg tggtgccggg tgaggcgctc caggacgggg
     5641 atgatctcgc tcggctccgg agcggtcagc aggtccgtgt acagctccgc cgcggcgtcg
     5701 cggaaggacg gcgcggtcag caggcgggac agccccgcac gcagttcggc accggtgtgc
     5761 cggtcgacgc gcacccccgt tcccacgccg ctctcggaga ggaaccggcc cgtgatcgga
     5821 gcttccatgg ggtagccggg gtccatcacg acgaactgcg ggatccggtt gaccagggcg
     5881 gcgccgaacg atccgtggcc gccgtggtgg atcaccgccg aacaggtcgg cagcagttcg
     5941 gtcagcggga ggtagtcgac ggtccggacg ttgtcgggta tccggtcggc caccgcgagc
     6001 tgggaggcgt ccagcgtggc gacggcctcg atgtccagtc cgtccaccat ctccagcacc
     6061 cggttgacca gcagcgcgct gtcccgcccc caggcccgga tcgaggaccc gagcgtgatg
     6121 gccacccgcg gtcgtgcggg cggctccctc agccagtcgg gcagcacggc cgggccggtg
     6181 taggcctgcc agcgcatcga tacggtgcgc ttcacggtgg gcagccgcat ccgctccagc
     6241 accgggttga ccgtccactg cccgaacagc agctcctccg tcatggggag cccgtagcgc
     6301 tcggccatcg gccggaccga cgaggtcatc ggctcctcgg gcaggagggc gtcaccggag
     6361 agcttcctgc accgggtgta ctgctcgtgc gcccagccga acaggtccgg gccccacagg
     6421 atgcgggcgt gggccgcgcc ggacacccgg gcggccacac cggcggccgg catcgtgggg
     6481 tcccacagga ccagatcggg ccgccaggaa cggcagaagt cgaccagcgc gtcgagggcg
     6541 tactggggtt caccggcggg ggcgcgctcc ggctggaagt cgcggaccgc cggcagcatg
     6601 tagtcccggt agtaggtcca cacgtaccgc tcgtagctgt ccagttcgag ggacttggtg
     6661 atgcggacga ggtcggcgta cgtgtccggg gagatggggc ggccggcgcc cagcggctgc
     6721 ggcagggtct cctcgtcgcc gagcgacacc cccgtcagcc ccgtcgcgtt gatcgtgtcc
     6781 agcagcgacg ggtgggagat gacccgcacc tcgtggcccg cgtcgcgcag ggcctgggcc
     6841 atcggcacac tggggtagag gtgggccgcg gcgggccagg tgcagaacag gacgcgcatg
     6901 gtcgtcttct ctccgacccg ctcagaggcg ggtcatggcg gcgaaccagg cctgggcgac
     6961 cccggggctg aaggcgacgt cgagttcggc tgcttcgagc gtgtccacgc gccacccggc
     7021 gccggtgaaa ctctcccgga cggcctgctc gggaacgcgt cgcggacccc aggtgcccgg
     7081 ctgccggtcg ctgaagcaca tcaggaagca gcgtccgccg ggcggtacga cggaggccat
     7141 gctgcgggcg acgaggggcc ggtcctcggg agcgaagcag tggaagagcc cgacgtcgat
     7201 gagcgtgtcg aactgctggc cgagcgccgc caggtccagg gcgtcccact ccaggaagcg
     7261 cgccttcagg ccgcgttccc gcgctttgcc gacggcgagg gtgatcgcgc tgggagcggc
     7321 gtccaccccc gtcgtctcca ggccgtgctc ggcggccagc agggcgttgt cgccgctgcc
     7381 gcagccgacg tcgagcaccc ggccgcggag cgcgccctcc tcggcgagac gcacgaggac
     7441 cgtctgcggc cgctggatct cccagccggc gcccggctcg ccggcgtagt gacgctcgaa
     7501 gacctccacg ccgctgtcgg cacgcgcgcc gactccggcg atccggtccg acggctcgct
     7561 catggtctcc ccccggaatg tgcggtcgat ccgccgaggg ccccgggagg ggccgtcggc
     7621 attctccgcg gaaagctagc ccacccctgg ggcccgcggg atcgaagtga tgggggctgt
     7681 gacacatatc aggaacctgc ctccgcgcct tgctgtcgcg gcgcggatct gtcagggcga
     7741 cgcgggggat ggggtttccc cgctttctcg tcactgtgcc ggggcggttc cgtgggtggt
     7801 gtccctcatg cgcggacccc gatgaacagc cccctgccgt tcggccagtc ggagaggaac
     7861 tccatctcgc accccgcctg ccggaaggcg tcgaggtatt cctcctgggt gaacagcgag
     7921 tacgtttcgt attcggtgaa ttcacggata ccggttgttt ccgcgacggt atagcgcacc
     7981 gtcatccggc tgatgcgtcc gtcccggacc gagtgcgaca gccggctgac ggcccggccc
     8041 tcttcctggg cgagggaggc cgatatgaac ccgtcgatga actgctcggg aaaccaccag
     8101 ggttcggcga cgagcactcc gcccggggcc agatgccgca ccagggtcgc cgcgctccgg
     8161 cgcagttcct cgacggtgct catgtacccc agggagaagc acatgcagag caccgcgtca
     8221 aaggtccggc cgagctcgaa ctgccgcatg tccccctcgt gcacgcgggc cgccggcacc
     8281 ctcctggtgg ccgtcctccg catctcgggg gagagttcga cgccggccac ggtgccgaaa
     8341 tgttcggcga accgctccag gtgcgcaccg gtgccgcagg cgacatcgag cagtgaaccc
     8401 gcttcgggac aacgctcccg gatcagccgg gtgatgccgt ccgcctcggc cgaccagtcc
     8461 cggccccggg ccgcgtggat gaaatcgtag atctcggcgt gctccgtgct gtacaccgtc
     8521 gaagggcgct gctgcgtaac catcctgatg ctccgtccat tgcgtggaga cctcggtgag
     8581 ctgtctgcgg gagccaaggt tctaccatcc cggcggcccg gtccggaggg gccggagccg
     8641 cccggtacgg ccgcttctgc gggccttcgg ccgtccaccg tccgcggacc gcgcaacggc
     8701 ggacggttcg gcggcacatg acagatgtca ggttccgtcc actgctcgtt gtccgcggcc
     8761 cggcgcggcg gcattgtgag ctctgccggg ctgcgtcaca ccacgtcaga cggccgccat
     8821 ctcccgaaac gccttccgat catgaacggg tacgcagcgt gatcacagac acagcagccg
     8881 ccggtccgga catgtccgag gcggcgggcg tacggctgta ctcccgggtg cccatcaccc
     8941 ctcgatggct ggcgaagacc gtgctgccgg tcagccgccg cctccgcgag gaccaccggg
     9001 ccgccctcct ccacctgcga cggggctggc tgcacggtcc gcacatcgac atcgtcgccc
     9061 ggagcgtgcc cgggcggccg gcgctcgact gggcggggat cgccgcagcc ctcgacgccg
     9121 gccccgccga gggcccggcc gtgacggacg aggagaccta tctcgcccag gcccgtgaga
     9181 tgggccggct ggaaggcgtc gcaccgccct acctgccgat gcgtgagcac ggtgccacgg
     9241 aggcgctgag cctctcgtcg gtcgagacct ggccccagcc gctccaggac ctgcgggaac
     9301 tggccctgga ccaactggac cggccgctga ccaccacggt cgagcagctg gccggggagc
     9361 cgcgcgaggc gccggtacgc atcatggagg cgttcgccgc cctggccgcg gcgcaccagc
     9421 acggagcagg gaacggggcg ttctcgatgc gttcgcacgc cgaggcgttc ttcgcctggg
     9481 cggccgcccg caaggacccc cgccccgcct tcgcccagcg gctggccgcc gacgcccccc
     9541 gcctgcggcc cgtcgtggag cgggcgctct ccggcacgcc cgaccacggg acgtcggcct
     9601 gggcccgtgc cttcgcctat tccatggggg ccttcgacgc cacggtcgcc cagggaaggc
     9661 tgaccctgga cgacgtcgac ggcctcggcg ccggtttcga cctggccacc atgggcccgc
     9721 ccggcgggga cggccgtgtg agcaccgaac ccagcgcctt ccaccgcacg atggaggagt
     9781 ccggcgtcat cgcctcgccg ccgcagtggt tcgcctccta ccggctgctc gtcaacctct
     9841 tctaccagca gctgccgctg ctgggcgtac cgcccatgca ccgctactac ttctgcttcg
     9901 ccgtcgccga actggtggac gacgtcctcg gctcctcctg gcaggacagg ctggagcaga
     9961 cgcgacagga gatggcgcag gccaccgccg gggcggcgga atgagcgaca ccgcggagcc
    10021 cctgtggatg ctgcgcctca acccgctgcg ccgcagaagg ctcgcggacc ccgggctcct
    10081 ggcggcgctc cgcacgctgg acggggccac gaccgaggtg cgcgaactgg ccgagcggtg
    10141 ctccgaggcg ctctacgaac tgatcggcgc caccaccgac cgggaggcgc gcgggcagct
    10201 catcgggctg cgccgcgcca tccacaacga caccgcccca cggccggcgc tgcgcgtcga
    10261 ccacccgctg gtcgaccgct ggtgggaggc ccggcagcgg cgggaggcac tcgccgccga
    10321 cgtggtcggc tgctacccgc gggcggtgga cgccgaacgc gggacgctgg ccgggctgct
    10381 gggcgacgag agcctgcggc actcgatgac gctggtggca cccgaggcgg cggccggcgc
    10441 gggacggtac agggcggccg tggccgccac cgagcccgtt cccacccggc tgcgcaagtc
    10501 cgagcgcggg ctggtccagt acgtcacccg ggccatgatc cgcaccagtc cgatggcccg
    10561 gttcaccgcc atcggccttg ccgtccccgg gccggacgga ccgggcccgg acgccccgga
    10621 gttcgggcgg gtggtgccct tccaggggct ggaccgcgtc atgctcgact acgtactggg
    10681 cgggctgcac acctcgggcg gcgacctcac ccccgacacc ctgatccaac tgccgcccac
    10741 gtccgacctg tcggccgaag gcgacctcct gtacttcctg cagcccggag ccgacggcgg
    10801 ggtgcgccgc ctgtcggcca aggtctccgg cgcggtcgga ctgctggtgg ccgcggtcgc
    10861 cgtcggtcca cgccgcgcgg ccgacgtcgt cgcggacttc gccgcacgct ccggctgtac
    10921 ccccgagctc gcgtggcagg ccctggcgcg tgcggtgggc gccggcatcc tgtgcacccg
    10981 cagccgcccg gaggacggcg cggccgactt cccggatctg ctcgaccccg ccggtctgac
    11041 ggtcccggag acggcccgga ggctgctgga gcagaccggc gccgaactgc gcgggctcgc
    11101 cgacgactcc gccgacgaac ggcccgaggc gctgagccgg ctgcgcgaca cgctggtcgc
    11161 gctgagccgc gaggcgggac ggccggcgca gatcctcatc gaggaggacg ccgtgctgga
    11221 ggacgtccgg gtgtccaccg ccgactggcg gagccagctc gacgacctcg ccgccggagt
    11281 ggccctgctg tccgtcttcg actggatgca cgacatacgg gcgttgctgt ccgccgtctt
    11341 cgtcgagcgg ttcggcgccg gcgccgaggt cccgctcacc gaccacgcgg actacctgag
    11401 cgccgagacc taccggcgcg cctaccgcct ccccgagaat gctcctcccg gcgaactggg
    11461 cccggccgac cgctcgttgg accggctgta cgccctgcgg gcgaacatcg tcgacaccgc
    11521 gatcgccgcc atcgaccagg ctgcggccac cggcgaggcc gtcggctgga gcgcctccca
    11581 ggccctcgac ctgaccaccg gcctgcccga ccgcttccgg accggcgacc tccgctacgg
    11641 cgtgctgacc cagacgtggc ggcgacagct gctgttcaac gaggcctacg cgggccacgg
    11701 catgctctac ggcaggttcc tcggaccgga ccgcgccctc ggcgggcgtg ccctgcccca
    11761 cttccgcgag cagctccgcg cccgctacgc cgagcaggac gggcggctgg tcgaggaccc
    11821 gggcctgcac cggctcaacg tcaacgcgca cccgccggtg ctcccggacc ggctggggcc
    11881 cgacgactgg ttccggctgc ggctgcgcca cgacccggac acggacgcgc tcggcatcct
    11941 ggaccccgac ggccgcccgc tgcacatgct ctcgctcggc accgggcacc cggagaggct
    12001 cccggcaccg ctccggctgg ccaactggct ctactccggc ggcgtgctgc gcgaaccctt
    12061 cgtggcgatc tggcacgccg agcggcagtg ggacggcgac cgcacccggg cctgcccgcg
    12121 cttccaggtc ggctcggcca tgctggcccg ccgccgctgg tacgggggcc gggagctgga
    12181 cgaggcggtg gccgcggggc ccgccgagca cgaccggctg ctggcgctcg cccggtggcg
    12241 gaaccggcac ggcgtgcccg aggaggtcgt cctgaagccg ccgcccggtg acggctccgg
    12301 cgagggccag gccaccggtg cgggccaagc cgccggtgag ggccggaaga agaagcccca
    12361 gtacgtcgat ctggccagcg ccctcagcgt gcgcgtgctg ccccggatgc gggaacgggg
    12421 cgacgcggcc tatgtggagg aggcgcttcc ccgggtggcg gacagcccgc acgccctgga
    12481 gtggatcgtc gacatcggcc gcgctcccga cggccccttc cagtacggag gaaagacccg
    12541 atgacgctac gcgcgcgccc ccatctgcac tatgcgccgg tctcggaagg ggtctacttc
    12601 aacggccccc gcacccagtt cgtgatcagc ggcccccaac tgctctaccg ggtcgccgac
    12661 acctgtgtgc cgctgctgga agcgggaacc acggaggacg agctggtcac cgcgctgggc
    12721 agcgaacggg cccgacccgt cgtccgccgg atcgtcgacg agctgcgggc ccgcgatctc
    12781 ctgctcgacc tgggcgcgct gaccgtgccc gagccgtcgg ccgagatccg cgcccgctac
    12841 ccggaggccc tggcacacct ggagacggag tgtgccgacc cgtacgccgt cttccagcgg
    12901 ctgcgcgcca ccgaggtgct gctgtgcggt ccggccgatg ccgtgctgcc ggccgcccgg
    12961 ggactgcacc gggccgggat caccggtctc acgctggcca ccccggactt cgaggccgcc
    13021 gctgccacca cctcccggct gggcctgcgg ctgctgccgc tcagcgactc cgcttcgctt
    13081 ccggaccccg gggacctgcc cgtgccgccg gacgccgccc tctactgccc cggcgcggac
    13141 gacggcgtga ccccggaagc gctgaccgcc ctgctgcccg aggcggcgct gctggtcccg
    13201 gtgcgctggg acggtctcgt cgccgccgtc gggcccgccg cccccggtgg tgcgtcgctc
    13261 ccgggctcgg ccgcgctcat cggccgggcc gcgcgctggg ccgcggccga cgccgacgcc
    13321 gccgcccccg cccctcaccc cacggccgag gcgctggccg gggcgctcgc ggggcagctg
    13381 ctgttcgaca ccctcgcggg catcgcacag cccggcgaag cgcatgtcct ccacggtgag
    13441 gagctgacgg cggaccaggt gagggtcgcg gcccccggca cagcttacgg tgaagccgcc
    13501 gagcggcgtt tcctgacagc cgcgcccgtg tccggcgccg aacccgtacc gccgcccacc
    13561 cccgacgagg ccgtcgaggc ggtgaccgcg ctcaccgggc gctggaccgg acccttcgcg
    13621 ctgctgggcg gcgaggaact gccccagatg ccgctggccc tgcgggagat ggccgaccgc
    13681 gacggcggcg ccggctccgt ggtcgcctgg gccgaggagc agcggacggc gacggtcgcg
    13741 gtcgccctcg ccgcgctccg ggccgcctgc ccgaccccgg gcgccgccgc cgcgggtctc
    13801 accgaggagc actggctgct ggacggcgcg ctgcggctga tggccgatga agccgtgccg
    13861 tacgcgacca gggccgtggg ggccgtggag gcgcgctcgg cgccgctgct gcgcatgctg
    13921 gaggaagagg gcatgccgga cccggcgttg accctgctgc gccaccccgg cctggactgg
    13981 acgctggcgg aggtacggac ctccggcggg ccgcagccgt ggaccggacg gagctggggc
    14041 cgtgacgaaa cggaggcggt gcaccgtgcg ctggccaccg cgctggcccg gcaccagacc
    14101 cacggggtgc ccggcgcggg ccccctggcc gaaggcgtgc acaccgacgc cctgctgttc
    14161 gccgacgcct cggcgcaggc cgcgctgcgc aagcagatcg cggacgcggc ggcggccgcc
    14221 gggctccgct acgagggcgc cccgcgtcga ccggacccgg tgaccggcgc gttgccgctg
    14281 tggtcgggcg gtgtccgggc cgtccccctc gacggagagc cgcaggcggc ggaggagagc
    14341 gccgaggaga ccgcccatgg ctgagaacgc gaccaccgtg gcctgcgcac ccgccctggc
    14401 cgacgccgag ggcaccgact ggcgtgccgt gctggagccg cttggcgcct ccggggacgg
    14461 caccgtcggc gccaatctcg gctgggacct ggactgggaa cgcgagcagc tgcggtccgc
    14521 cgacgggcgt gagcatctgt ccgttcgcgt ctacggcgac gaggtgctgg tcggcccccg
    14581 ctgggtgccc gggacggact ccggctgcgc gggctgcgcc gagctgcggt cccggctggt
    14641 gatcgaccac cccctgaccg atgacctgac ccggcccacc tcgcgggtcg ccccacgccg
    14701 cccgttcctt cccgagctca cccgtgcggc gctggcgcgg ctggccgtcc gccccctggg
    14761 gccgggcgag ttgtacgcgg tggggtcgcg ggggacgcgg acgcaccgca taccccgcca
    14821 cttcgcctgt ccgctctgcg cgccggagat ccccgaacga ccggtgggga ggccgccgca
    14881 gcccttggcc ctccggtccc gccccgccgc ctcggacaat ccgggccggg ccgcggccgg
    14941 ggccgggctg gtgcggcccg gtgcgctgcg ctcacgactg gtggatccgc gcttcgggcc
    15001 ggtcctcgcg cagcaacggg aactgctggc ccccttcgcc atgagcatgg cgctccagcc
    15061 cgacgcggtg gccctcggct acgcccgcga gacgaccttc gccaaggcgg acccgatcgc
    15121 catcctggag gtgtacgagc ggctttcggg cttcccgcac caggcgccgc tcgtcgaggg
    15181 agtctcgtac gccgaactcg tccgcaccga gggcggagcg gagctggcgg tgcggcccgc
    15241 cgcgttcggc gagtacaccg aggagcaggc ggcgcgtccc accgcgcgga tcgagcgggt
    15301 gacggacgaa acgccgatgg actgggcgtg ggggcacgac ctggcggacg gccggccccg
    15361 gctcgtcccc gccgaactcg ccttcttcca gtacgactac cgctacggac gggaccagcg
    15421 ggcggcacgg cggcacggcg ccgcgccgcg ccggcatctg taccaggagt cctccagcgg
    15481 ctgtgcggtc ggctcctgcc tggaggaggc cgcgctgtac tccctgttgg aactcgccga
    15541 gcgggacgcc ttcctgatca gcttccaccg ggcccttccg ctgccggaga tcacccactc
    15601 ctcgatcacc gatccggtcg tccgggggct gctggcgaca gccgcctcgc gcggcttccg
    15661 ggtccatctg ctccgcgcca cccaggacat cgacctcccc gtggtctggg cgatggcggt
    15721 caacacacgc gctccgttcc cggccacgtt ctccgccgcg ggctccggca tcgacccggt
    15781 ctccgcggtc cggggggcgc tgtgggaggt ggtccagatg gcgaccgagc gcatggactg
    15841 ggaacgctcc gaggccgagc cgatgctggc cgacccctgg ctggtcgacg agatggacga
    15901 ccatctgcgg ctctacgcgc tgcccgagat gaaggagagg gtcacgtccg tgctgggcgg
    15961 gccggagacg agcctgtccg aggcgttcgc gggctggccg gaccggctgg aacaggtcgc
    16021 cgggggcgat gtgcgcgggg cgctggacta cgtccggggg aggtacgccg aggccggact
    16081 ggaccggatc gtcctggtgg actccaccac acgggaccac gccgacatcg gcctggccgc
    16141 cgccaaggcc gtggtgccgg gcatcgtccc catgtgcttc ggccaggccc agcaacgggt
    16201 ggccggactg ccgaggctgg aggcggcact ggccggaacc ccctccggcg agctgtcgcc
    16261 gccgtacgac ccgcacgcct tcccctgatc cccggacgtc ccccaggccc agcaggagcg
    16321 gcggattcgc gccgttgttc accgaaccac cgaaccaccg aggcagacgg agttccccat
    16381 gacagatacc agcgaccggg gcggccctgc gtcaccgatc ccggacgatg ccgatgtcat
    16441 gtcgcgcgac atgcggtggt tcacctacgc gacgggtctc ggcgtgcggg tggaggcgga
    16501 ggccgtcccc gagccccgcc cggacaccga ggtcgcgccc gcgctcccgg aggcggcgct
    16561 cggcgaccgg acgcccctgc cccggggcac gaccgagctg ctggagcggg cgccctatcc
    16621 gcacggccgg gtgggctccc cgcgcgagag tgccgacgct ctcgggcacg ccctggtcgc
    16681 gggcttcggg ctgcaacggc gggagccgga gaacccgttc aacgaccacc gcccctatcc
    16741 ctcggtgcgg gcgaagtttc ccgtccaggt gctcgtccgg gacggccgcc accgccgggt
    16801 gctcgacctc taccggcacg cgctgaccgg tgtgggacgc caggacgggg cggccggtcc
    16861 gctggaggtg gcgctggccg ggaggtacac ccggctgccc gactcctacc ggtggttccg
    16921 cagctccctg atcggcctcg aactgggcgt caacctgcgc cagttgtgcc tgggaatgga
    16981 actgttcggc ctgtccggaa ggctgcggct gccggaccgg aacgcgacgg gcctgctgac
    17041 ggacttcggc ctgacgcccg aggcggaatg gtccctgcca ttgacggtgg ccctggagga
    17101 cggcgcgccg cccgtcgccg cggccccggc ggagcgggct gccgacccgg tcctcgacgg
    17161 gatcctgacc gtcaaccgcg cccaggactt cacgggtccg gccgctccgc tcggcccgtc
    17221 cgtcccggcc ggtctgcccc ggcacggagc actgtcctgg gcggaggtgc tgtggcgccg
    17281 cagcgcggga cggatgccgc gcggcatgta cggcatgacc ggccgccgac ggccggtacc
    17341 cgagcggacc ctgcgcgagg ccgtcagctg gctgagcgtc ccgccccccg gcccgcaact
    17401 ggccgccgcc tgggaggaac tgcgcgtgac cgccgtgttc cagggcatcg acgggcacgc
    17461 cgacggcgtc tggcacctga gggacggccg gccgaccctg caccgggccc gtcccggcgc
    17521 cgcggccgaa ctggaaacgc actacggcta ccccgtcacc ccgtacgccg ggggcgacgt
    17581 ccggcacgcg agcgcggtgt ggttcctctc cgcgcaccca cgacggctgg tggaccggct
    17641 gggccccggc ggcttcaccg ccgcccagta cgcggcgggc tgggccgccc agggcatttc
    17701 gctggccgcc gccgccaccg gtctgtacgc gaggcccgca cgagccttcc aggaagtccc
    17761 gacgagacaa ctcctcggcc tggaccccga tgagatgatc gtctgcgctg ccatcaccgg
    17821 gaccccgcgc ttcgaggggc tgttgtgcga tctacgcctg tgacgaggga gcagaagttg
    17881 acggacacat ccgagaccgc gcgcgccggg ggcggcgccg gccccggcgg acccgacacc
    17941 gtgtggcgga cctggcatct gcacgtaccg agcggcgacc gaagcgccca cgaccgggtg
    18001 gtggtcgaca cggtcggacc ggtgctgcgg accctgccgg gccgcccgtg gttcttcctg
    18061 cgctactggc acggcgggcc ccatatccgc ctgcgcatcg gggacgtgac cgatgaccag
    18121 gcggcttcgg cggagcggct cctcgccgag cgcctcgtgg acgccgggcg gctgcgggag
    18181 ggcgagacgg cgatggaccc ggcggcctac gcgcggaccg ccgccgccat gaccacggcc
    18241 ggggaccagc cctcccacca ggaggtcacc ggcatgttgg agcccggtgt ccaccgcttc
    18301 gcctaccacc cggaacacga gcggtacggc ggccgggagc tcatgcccga gagcgaacgg
    18361 ctcttcgagc tctccagcag gctggtcctc gccttcctcc ggcgtgaacc ctccaccggg
    18421 gcccgcgccc tgctggccct gcgcgccacc gtctgcgccg cgcgggcgct cggcgacgac
    18481 cccgccgaag aggcggcctt ctacgatcac ggactgcgcg cctggcggac gtgggcggcc
    18541 ggctacggct acacggagcg acagctcgac gagctgtacc ggaccgcccg gccgaccgac
    18601 gagctgcggg ccaaggcgac cgggggagac accggaggcc cgctggcgcc gtggcaggcg
    18661 gcactcaccg gactgtcgga ccggatacgg cggcagaccc cgctccaccc ggcgcaggtc
    18721 accatctccc acgtccacat gctgcacaac cgcctcggtc tgcggactgt cgaggaatac
    18781 cagacctatg cccggctggc gaggctcttc cccgtccggc cggcccccga aggggcaccc
    18841 cctcccgacc actccggccc ggcgcagagc agcgcggtcc catcaaccga ggagcaccga
    18901 tgagcaccag ccccaccacc gccaccgcac gcgccggggc tccccccacc ccggccgtcg
    18961 tcgcccgagc catcggcgtc acccggcact acggggacac cgtcgccctg gacaacgtgg
    19021 acttcaccgt gcgggagggc gagttcatcg gcctgctcgg gccgaacggc gcgggcaaga
    19081 ccacgctgct caactccctg ctggggttgc gcaagccgac ctccgggcgc atcgagctgt
    19141 tcggaggctc ccccacgaac ccggccagcc ggcggttcat cggcgtcacc ccgcaggaga
    19201 gcggagttcc gccgaccctg cgggtggccg aagcggtgga cttcgtggcc gcgcacttca
    19261 aggagaccga ggaccgggac gagctgctgg agcggttcga cctgaccaag gaggcccgcc
    19321 gccaggccgg tggcctctcc ggcggacaga agcgccgtct ggcgctcgcc ctggcgttcg
    19381 tcgggcgccc gcgcctggtc atcctggacg agccgaccac cggcctggac gtggagtccc
    19441 ggcggatgct gtgggaccgc atccgcgagt tccacgaggg cggtggcacg gtcctgctca
    19501 ccacgcacta tctggaggag atcgaggccc tggcgaagcg ggtggtggtg atcgcccagg
    19561 gtcgcatccg ggcggacgac agcgtgggcg ccatccgggg gatggcccat atgcagcgcg
    19621 tgtccatgaa cgccggaccg ctgccggacc tgccgggcgt catcagcgag gagcggacgg
    19681 aggagcgggt cgagctgatg acccacgacg ccgatcagct ggtccgggca ctggtgcgtc
    19741 agggcgtgga gttctccggc ctcgccgtcc agcaggccac gctcgaagaa gccttcctgg
    19801 tgatctccca gtcctgatcc accgcacctc ccacgaaagt gcctgaggcc atgtcatcac
    19861 tgacccttgt ccatgcccgc taccagctgg tcgagctgag ccgcatcccc atggcgatca
    19921 tcggcgcggc cttcttcccg gccgcctcgc tgttcttctt cgtggtgccc aacaccaagg
    19981 acgaccccgc cggggccacc ctcgccaccg cctcgatggt ggtcttcgcg gcgatgatca
    20041 gcaatctctt cggccacggc accggtgtgg ccgaagaccg ctcccagccc tgggacccct
    20101 acacccgcac cctgccgatc ggcccggcgg tgcggttcgg cagccgcatc atcaccggtc
    20161 tcgcgatgat gctgttctcg atgttcccgg tcgtgatcgt ggcggcgttc ttcacccccg
    20221 ccaccatctc tccggtccgc ttcctgctgg cgatcggcgt ggtgatcatc gtctccgtgc
    20281 cgttcaccat gatggggctg gcgatcggct acctgctctc caccaaggcg gcgatcgcca
    20341 ccgtccaact cgtcttcctg ccgctggcct tcgcgggagg cctgctgggc ggtccgggcg
    20401 aggcgcccgg attcatcgag acgatcgccc cgttcgtccc gacgcgcggc tcggccgagc
    20461 tgatgtgggc gaccgtcggc gacttcgaga tcaatccggt ctccatcgtg tcactcgtgg
    20521 tctggaccgt cggcctggcc gccctcgcct tctacgccta ccagcgtgac gagggacgcc
    20581 gctaccactg agagcctgtc gggcgacctc tgatcgggcg gccacgccct ggcacacacg
    20641 cttccggtgt tgccggaatg gcctcgtagc tccgctacga ggccattccg gcgccttgga
    20701 atcgcacgca ccacgccgcg tccgcttccc gatcgaaggt cacccgacag gctctgagcc
    20761 ccgtcgggcc gctcaggcgg acccggcggc tgcgcccggc cctccggtgg ccgggcgcag
    20821 ccgccgcccg aactccgtga gcagcgccgc gagcccgtcc gcgtcggggg ccgcgccgaa
    20881 cagatagcgg tcgggccgga tcaggacggc cccggcaggt atcgactcca gccagggcag
    20941 acagcggccg tcggtgtcca gcaccgtgtc cggcccggga gccgaaccgg cgtcggcgcg
    21001 caggacggtc accacccggc cgtgtaccgg ccgcagggtc tccagcgcgg cgggggacag
    21061 ggcgtccgcg aggttctcgc ggcacagcag tacgaagccg gggccgagca cggagtcggc
    21121 cgggcccggg ccgtcggggc cggacagccg gacctggccc atgagttcac ccgccggggg
    21181 tccgccgtcg gcgaggaagc ccttggccag gtgttcgccc agcgggctcg cggagcgggc
    21241 cgggccgccg gggcgcgccg ggccggcggg gcgggcggtc atcgcccggt ccctgtccgc
    21301 cgccgcggcg gggtcggtca ggcagatcag gcgcccgagc cgcacggaca ggtcgatcgc
    21361 gtgctgaacg tgggcgcggc gctcctgctc gtagctgtcg aggagagcct ccccggccct
    21421 gccgcccagt accaggtcca gcttccaggc gaggttcgcg gcgtcccgga agccggagca
    21481 catgccctgg ccggcgaacg gcggcatctg atgggccgcg tctccggcca gcagcacccg
    21541 cccacgtcgc cagtgctcgg cgttgcgggc ccggaaggtg taggtggcgt gccgggtgag
    21601 tgtggcgttg tccggtctgg cggagaacat cgacaacagc cgccaggcgt tctcctcggt
    21661 gccgaactcc gcccggtcct ccccgggcat ccgcatgaac tcccagcggc ggcggcccgg
    21721 tccgcaggag acggccaccc ggggccgggc gggatcggcg acctggaggt tggacggcgg
    21781 gaagtcctcc gggcggtgcg gcaccacatc gcaggccagc cagtccaggg cgaagccgga
    21841 gtcggcccag ccgacgccca gggagtgccg cacgaagctg cccgcaccgt cgcagcccac
    21901 cacccaggag gcggtgaagg tccgccgctc gccgctgcgt tcgtcctcgg cgaccagctc
    21961 ggcgccggag ccggattcgg tcagctccac ggcacgcagg ccgcggatca cgcgcagcgt
    22021 gggcagttcc tcgccgcggg ccgcgagcgc ggcctcaagc cccggctggt acacggaggt
    22081 ggagtccggc cggcccggcc cgtccgagcc gcccagcccg atccgcagaa gctgccgtcc
    22141 ggcggcgtcg ctgaccacgt agtcctgcga gggttcggtg atgtccccga tccgtccgga
    22201 gacgccgacg gcgtcgagcg tccgggcggc ctcggcgtcg aacgccaccg ctcgcggcag
    22261 actgtacggt tccggatggc gttcgacgac gacgacccgc cacccgtgct gggccagcag
    22321 gatggacagc acctgcccca ccggcccgta gccgacgacc aggacatcgg cctccggagc
    22381 gccggcgctc cgaccgcgtg acccagatat cccgttcatg cttctcctgt cctgaatacc
    22441 catggtgttc gggccgtacg cgggcaaccg tgataatcga ggcccaccgt accgattcat
    22501 caaagcgaca tttgtgcccc ttcgatcggc ttccaggcgg aggctggtga caaatgtcag
    22561 cgccgcttcg cgagagattg ccagcgcctg aagtgaccga aattatccat ggtgccactt
    22621 ctaccgaatg gcagtcttaa tcaagaaggg aaatcaagtc aatgagcatg gccattgagg
    22681 cgatgaacgc ggacgccctg ttcgactcct tcgacatcga ggagctggac accatggagg
    22741 tcgccgacgg cgttgccctg cccgagatgg gcgcctccac cggcaacacc atgtgctgct
    22801 cctcgtcgtc ctcctcctgc tgctgaggta gggacgccgg ctgtccgtgc ggcggggtct
    22861 cccgacgcgc agacagcgtc accgaggtga agcgcatgct cggcaggcgg ttgtccggca
    22921 ggaattgatg acaaatatca gcgccgcgcc aagggtaatt gcgtgtcggg ttccggatgg
    22981 aaatcgtatg caccgtcggt cccgtggccg gcgggccaga gcttggaggt acaccaagat
    23041 gagcaagatc ctggagtccg tggacgcgga cgcgatgttc gactccttcg acatcgagga
    23101 gctgggcacc atggagctcg cggacggcgt cgccctcccc gagatgggcg cctcgaaggg
    23161 cgacttcacc tgctgctcgt cgtcctcttc ctcctgctgc tgaggtaggg acaccagctg
    23221 tctgcgcgac gggtctcccg acgcgcagac agcgccaccg acgagcattg agcatcgggg
    23281 gaggccattt cgtttccggc gggaaacgct gacaaatgtc agcgcccggt cacgggtcat
    23341 tgcgtgccgg gttccggttg gaaatcgtat gcaccgccgg tctcgtgagc tgtgccgctc
    23401 gtccccattc tcatctgccg ccccggcggc agacagcacc acccgcgcaa caagctttcg
    23461 gcaggcggct gtccggcggg aatcgctgac cacgtcagcg ccgaacccca agggcgatcg
    23521 tgtgccgggt accggttgga aatcacacgc acgccggtct ccccggccgg cgggccaaga
    23581 gcttgggggt acacacaaga tgagatcgac cctggagtcc gtggacgcgg acgcgatgtt
    23641 cgactccttc gacatcgagg agctggacac catggagatc gcggacggcg tcgcgctgcc
    23701 ggagatggcc gcgtcgagcc tgcccgtgac ctgctgttcc tcctcctcgt cctcctgctg
    23761 ctgctgctga tcccgcggcg cagtgctgcc tgcgcggcgg gcgcagcgcc caccgcgcag
    23821 gcggcaccac cgggtggtcc gcccagcgga gggcgggccc ggcgcccggc cccgaacgga
    23881 tggtcgtgac attcccgatt gatgtgcccg actcctgggc cggacatgag cactacgcgc
    23941 ggcgcgtgct gtggcggctg gcccgccaac cctccctgcc caccctgtac ttccagggcc
    24001 gatggctgaa cggcgcgacg ctggccgacg cggtacgcgc gaccgcggtg ggcctgcggc
    24061 gggccgggct gacccccggc ggcacggtgg cggtgctcac cgaacccaac caccccgcga
    24121 tgctgatcgg ccgctacgcc gctcacctcc tgggggccgc ggtcgtccag gtgcgctcgg
    24181 ccaacccccg ctcggacgcg ttcccgctgc ccgccgccac ccaggcgcgg atcctcgacg
    24241 ggaccggcac gtccgtgatc ctcgtcgacg ccccccaact ggagcgcgcc cgtgccctgt
    24301 tgtcgctgac cgagggccgc ccccgcctgc tgggatacgg agtcggcgcc gccgactgcc
    24361 ccgacgcgct gtcctgccgg gacgagcctc tcggagaact ccccacccat tcccccgacc
    24421 gccgcgccct ggtggccttc accagcggga gcagcggtac gccgaagagc atcgatcaga
    24481 ccttcggggt ctgggacagc accgtccggt ccgcggcgag cggcgaaccg gacgagcggc
    24541 gggtgttcct cgccgtgacg cccctcagcc acaccatcgg agccatggcg gactcggtgc
    24601 tggccgccgg cggccaggtc ctcctgcacc aggacttcga cgctccgagg gtgctgcggg
    24661 ccttcgagga ccacagtgtc accgacacct atctggccgt tccgcacctg taccggctca
    24721 cggaactgct ggccgactca ccgggccacg agcagggccc cggcccgggc cccgtcgggg
    24781 acgccctgtg gtcgctgcgc cgcgtcgtct acagcggcac ccccgccgcg ccgcaccgga
    24841 tcgccgaggc cctgcgggtg ttcggcccgg tgctcgtcca gctgtacggc accaccgagg
    24901 ccggcggcat cagcaatctg agcccgttcg accacctgga acccgaactc ctgggcagcg
    24961 tggggcggcc gctgccctgg gtggaggtgg aggtgcgcga tcccggcacc ggcgacccgg
    25021 tgccgcgcgg ggaggccggg gagatctggg tacgcgcctc cacggtcatg gacggctacc
    25081 cgaacgaccc ggagcagacc gcccgcgtcc tgcgggacgg ctggctggac accggcgacc
    25141 tcggccactg ggaccgctac ggctatctgc ggctgaccgg ccgcagcggg caggtcatca
    25201 agtccggcgg cctgaagata tatcccgccg cggtggagcg cgcgctgctc tcccacccgg
    25261 cggtacggca tgcggccgtc cacggcgtac gggatccgga ccggaccgag tacgtccacg
    25321 cggccgtcgt gttcagggcg ggccggacct cctccgcgga ggaactgcgc acccacgtag
    25381 gcgagctgct ctcccctctg cacgctcccg ccgagatcac gttctgggac tcgatgccgc
    25441 tcaacgagcg cggcaagccc gacctggcct gtctgcgctc cggtaacggc cggcaggcgt
    25501 acgacggtgc accgccgaag ggaactccat gaccacacac cagcacttcg gccgcgctgt
    25561 gcggctgcgc cggctgttcc accacgaccc ccagcggctg atgatcgtcc cgctcgacca
    25621 ctcgctcagc gacggcccgg tggtgccgcg cggcagcagc atcgatcggc tcgccgggca
    25681 gctctccggc gccggggtgg acgcgatcgt ggtgcacaag ggcagcgtcc gccacatcga
    25741 ccactcccgg ctggccacga tgtccctgat cctgcacctg aacgccagca ccgcgcacgc
    25801 gccggacccg gacgccaagc acctggtcac cggggtggag gcggcgctgc gcctgggcgc
    25861 ggacgcggtg agcgtgcaca tcaacatggg ttcgcgggaa gaggcgcggc aactggccga
    25921 cctcggagcg gtggccgacc agtgcgaccg ctggaacctt ccgctgctgg cgatgatgta
    25981 cccgcggggg ccgaagatca ccgaccccgc cgaccccgaa ctggtcgccc acgccgtcac
    26041 cctcgcggcc gacctgggcg ccgacctggt gaaggctccc tgcctgcgga cgcgggcgga
    26101 gatgcgggac ctcaccgcgg cctgcccgat cccgctgatc tgcgcgggcg gcccgcagcg
    26161 cgacacggag gacgaggtgc tggccttcgc ccgtgaagcc gtcgcgggcg gcgcggccgg
    26221 agtcgcgatg ggcagaaaca tcttccagtc ccccgacccc ggggcgatgg ccgccagggt
    26281 ggctggagtc gtccacaacc gccccggggg cacgctcggt cacatcgagg aagggcacgg
    26341 cagtgagctc agagaaactg tgctggcttg acatccgttc ggccggcaag gcccggcagg
    26401 ccatcgtgga ggaggcgctg caccagcgga tcgacgccat agtcgccgcc gacccggccg
    26461 atctggaggg gctgccgccg accgtcacca aggtcctgat gcctccgccg ggcaagcagc
    26521 ccgcgagcta cggctccgcc ggggtcgtca tcctcgccgg ggacgcctcc gcccgggcac
    26581 aggccgccga ggccgctccc gacgtggagt tcgggcggct ggtggagatc accgacgcag
    26641 agagcctgga cgccgccatc gaggcggccc gcaccgaacg ctggagcgtg ctggagttcc
    26701 gggacccgac caagatcccg ctggagatcg tgatcgccgc cgccgccgac gccgacggcg
    26761 ccatcatcac catggcgaag aacaccgagg aggccgctgt cgtcttcggc tgtctccaac
    26821 tcggctccga cggcgtgctg atgcccggcc ggagcgtggg cgacgccacc gcgctcaagg
    26881 cgaccgcggc cggcggcacc ggcgaactcc tcctcgtgga gctggaggtc accgccgtgg
    26941 cccacatcgg catgggtgag cgcgcctgcg tggacacctg ctcctatctg ggcaaggacg
    27001 agggcatcct ggtcggctcg cactccaagg gcatgatcct ctgcgtcagc gagacccacc
    27061 cgctgccgta catgcccacc cgccccttcc gggtcaacgc gggcgccatc cactcgtaca
    27121 ccctcgccga cgagggacgc acccgctacc tcagcgaact gagggccggg agcaaggtga
    27181 tggccgtgga caccaagggc cggacccgga cggtcgcggt ggggcgggtc aagatcgaga
    27241 cacgtccgct gatctccatc gacgcggtgg ccgcgggtgg ccaggaggtc aatctgatcc
    27301 tccaggacga ctggcacgtc cgggtgctgg gaccggggga cgccgtgctg aacagcaccg
    27361 aactccgccc cggggaccgg gtgctggggc atctgccgac cgccgaccgc catgtgggct
    27421 acccgatcga cgagttctgc catgagcagt agcgccccgg cgccgggcat cgcggtgatc
    27481 ggggcgggca tcggcggcct caccctggcc gccgcactgg cgcggctggg catcggctgc
    27541 cgcgtcttcg aacgtgccga gcagcctgcc gaggccggcg ccggggtgca gttggggccg
    27601 aacgcggtcc ggctgcttcg ccgtctgggg ctctccgatt ccctgcggca gcacggcgtc
    27661 cgcccgctct cccgcgatct gctgcgctgg gaggacgggc ggctgctggc caggaccgag
    27721 ctcggcgagg cgtgcgagaa gctgttcggc gcgccgtacg tcaccgtgca ccgcgcggac
    27781 ctgcaccggg cgctgcgtga cctggtcggc ccggtggtgc ggaccggtca ccggctgacc
    27841 gggctggcgg aggagcccgg cgccgtcgtg ctgcgcttcg ccgacggctc ggagcaccgt
    27901 tcggagctgg cggtcggtgc ggacggcatc cgctcggtgg tacgggaaca tctcgccgcg
    27961 gacgccccgg tcttctccgg ccgacggatc taccggggtc tggtgccggt ggagcgggtg
    28021 ccggaactgg ccgacgagcc ccgcgtccag gtgtggctgg gacccggccg gcactgcgtc
    28081 tgctatccgg tctccggcgg ccggctgatc agcttcgcgg ccaccacggg cggtaccgcc
    28141 ctcccgggcg agtcctggac cgccctcggg gaccggggcg aggcggccga ggccttccag
    28201 gggtggcacc ccacggtcac ccggctgctc ggggcgggcg gcggcatcgg ctgctgggcg
    28261 ctgcacgatc gcgagccgct ggcgcgctgg tcgtccgacg ccctcaccct gctcggcgac
    28321 gcggcgcacc cgatgctgcc gttcgccgcg cagggcgcca atcaggcgat cgaggacgcc
    28381 ttcgcgctgg cggcgacgct ggcgctgtcg cgcggcgaca tcccggaggc gctccgccgc
    28441 tacgaggagc tgcggatccc gcgtaccgat cgcctgcagc ggtcggcccg gtccgtggcg
    28501 gtcggttcgc atctgccgga cggaccgctc cagcgggcgc gcgacgcgga gctggcctcg
    28561 ggttcggcgc tggaggggct gcgctgggtg tacggccatg acgccctggc cgccgcggca
    28621 cggtggaccg cggagcggca gaaggcgtga gcgggcggga tccggaccgc gcgcggcgat
    28681 cgggcagcca cccgcgtccg tatccacccg tcccgctcgc ggttcgggca ccccgaacgg
    28741 ttccggccgg ggccgaaaag ggtagatagc tgggtaagtc cccttgggga ggctgattcg
    28801 atgccgtggt tcgcttggct gctcgccgcc gcggcgctcg gcgccgcgga gttcttcact
    28861 ctcacgctgg ttttcgggtt gctggccgga gcggcgttgg tcg
//
