LOCUS       NZ_CP096281            25263 bp    DNA     linear   CON 08-JUN-2024
DEFINITION  Streptomyces sp. WAC00303 chromosome.
ACCESSION   NZ_CP096281
VERSION     NZ_CP096281.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. WAC00303
  ORGANISM  Streptomyces sp. WAC00303
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8548838)
  AUTHORS   Meyer,K.J., Tan,S. and Nodwell,J.R.
  TITLE     Genome Sequence of WAC00303 Direct Submission
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8548838)
  AUTHORS   Meyer,K.J., Tan,S. and Nodwell,J.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-APR-2022) Biochemistry, University of Toronto, 1 Kings
            College Circle 5207, Toronto, ON M5S 1A8, Canada
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 15-MAR-2022
            Assembly Method                   :: Flye v. 2.8.1
            Assembly Name                     :: WAC00303
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 58.0x
            Sequencing Technology :: Oxford Nanopore; Illumina NextSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023210535.1-RS_2024_06_08
            Annotation Date                   :: 06/08/2024 05:21:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,823
            CDSs (total)                      :: 7,731
            Genes (coding)                    :: 7,293
            CDSs (with protein)               :: 7,293
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 438
            CDSs (without protein)            :: 438
            Pseudo Genes (ambiguous residues) :: 0 of 438
            Pseudo Genes (frameshifted)       :: 228 of 438
            Pseudo Genes (incomplete)         :: 241 of 438
            Pseudo Genes (internal stop)      :: 26 of 438
            Pseudo Genes (multiple problems)  :: 54 of 438
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:23:54
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3978551
            Orig. end                         :: 4003814
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP096281.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Justin Nodwell, University
            of Toronto.
FEATURES             Location/Qualifiers
     region          1..25263
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="11"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25263
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25263
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15263](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15263)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     assembly_gap    517..526
                     /estimated_length=10
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            <527..1214
                     /locus_tag="MWG59_RS18420"
                     /old_locus_tag="MWG59_18420"
     CDS             <529..1214
                     /codon_start=2
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MWG59_RS18420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MWG59_18420"
                     /product="hypothetical protein"
                     /protein_id="WP_248585330.1"
                     /transl_table=11
                     /translation="GRAPLSPEQGTTMTTQLLERPTTVTVPDTTGGRLIVPSTHGTTTV
                     PAYRVGAPDIQCRYPVIVGEDQVIGRAYRWHRDWLVLTTVGEHNLRRPPKGTPGTEMAA
                     AHLAEQYAAGRIDAVPLDQVLAEAPTPLCGPVPLLHPRMPVNDRNIEGALIAFAGLRAH
                     HWRAVLTGFPGSDNHWYLSCELCPWEGPKFWSHLRGRNGEPPSARRHKGGCIGEEKVRR
                     LIPAYH"
     assembly_gap    1230..1239
                     /estimated_length=10
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            <1240..1694
                     /locus_tag="MWG59_RS18425"
                     /old_locus_tag="MWG59_18425"
     CDS             <1244..1694
                     /codon_start=3
                     /inference="COORDINATES: protein motif:HMM:NF040349.3"
                     /locus_tag="MWG59_RS18425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18425"
                     /product="DUF6197 family protein"
                     /protein_id="WP_248585331.1"
                     /transl_table=11
                     /translation="PALWKDTAVPTRHTPESIVIADTPAAILEWAARHIEHVGIHQGPH
                     LFAGPGRTATLPCWPRGALQVAAGHGRGAAGRTYDWDRINRARDQAFGILAETLTGHPV
                     DADDPATANARHREAIDRWSADPGRTAADAAHAFRTAAARAEHALF"
     gene            1735..2133
                     /locus_tag="MWG59_RS18430"
                     /old_locus_tag="MWG59_18430"
     CDS             1735..2133
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040345.3"
                     /locus_tag="MWG59_RS18430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18430"
                     /product="DUF6181 family protein"
                     /protein_id="WP_248585332.1"
                     /transl_table=11
                     /translation="MDETTASRSTTRTPTRRGAATPSRDGVHRLSVPLHPRLSATELIR
                     VLLAAPGENDLTALDPVQVRSLIADVLTQHGYDVLDRSPYYPELDRHQDARRAVRRAYG
                     PRFLDAPDEQAVLADPLREVLAAGSRKS"
     gene            2130..2738
                     /locus_tag="MWG59_RS18435"
                     /old_locus_tag="MWG59_18435"
     CDS             2130..2738
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040384.3"
                     /locus_tag="MWG59_RS18435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18435"
                     /product="DUF6349 family protein"
                     /protein_id="WP_248585333.1"
                     /transl_table=11
                     /translation="MTVPAAEPTGARARQTYYWRVRNARTRHRPESAGQAWHIQPGHPG
                     GAYCDLGHDLDPPAHHTPTLLSRSRPTGRWGDGQEFRGGCLACEWEGPVHCGGGFGDGD
                     NEAVEDAHDHAFPGWRTLPPITAVEDRWAVPRSRSRWAQLTAPYPAGWVDQGAPVVAWR
                     RYRREAHLPPHAGRPRYELRITRPPRDRARRPADQDALF"
     misc_feature    2782..2798
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.82"
                     /tool="antismash"
     gene            2936..3214
                     /locus_tag="MWG59_RS18440"
                     /old_locus_tag="MWG59_18440"
     CDS             2936..3214
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040353.3"
                     /locus_tag="MWG59_RS18440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18440"
                     /product="DUF6211 family protein"
                     /protein_id="WP_248585334.1"
                     /transl_table=11
                     /translation="MLCDRHPDCPQPGDIAQLTRGNSIGADPGESFVIVEDFPPTGRHL
                     VLNLPVDHPGRADWAAAVPPADIATLTRLEPAGSRTWTPAPDPDEIQ"
     misc_feature    2937..2947
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 17.67"
                     /tool="antismash"
     gene            3259..3912
                     /locus_tag="MWG59_RS18445"
                     /old_locus_tag="MWG59_18445"
     CDS             3259..3912
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447328.1"
                     /locus_tag="MWG59_RS18445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18445"
                     /product="hypothetical protein"
                     /protein_id="WP_248585335.1"
                     /transl_table=11
                     /translation="MSPKTGRTLYSRADLRKVHGISEPTLQNLWTDRENNGHPPVEETI
                     DGVMHWDGDVWATWHHELQRQRAAASTTNPPKLDGDPEEMVGPAEAAKVCGFADSTTVS
                     HYVKNPPEGWPAPDDWDELPTRRRPKWKRWRLWQYLADRKGRGHAGGRPTGRRGLAYPY
                     QGDERLTLARQAIAANPGAKNAELIPELQKQTEKTYSRPTWNLILKSARENPEE"
     gene            3916..4092
                     /locus_tag="MWG59_RS18450"
                     /old_locus_tag="MWG59_18450"
     CDS             3916..4092
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014043957.1"
                     /locus_tag="MWG59_RS18450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18450"
                     /product="hypothetical protein"
                     /protein_id="WP_248585336.1"
                     /transl_table=11
                     /translation="MPDTRCPRCGGPLGERPARSRLTAAREVPICTTCGTEEAVREAQG
                     QAPVPFGEWPLNT"
     misc_feature    complement(4622..4637)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.71"
                     /tool="antismash"
     gene            4743..9173
                     /gene="mobF"
                     /locus_tag="MWG59_RS18455"
                     /old_locus_tag="MWG59_18455"
     CDS             4743..9173
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene="mobF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447327.1"
                     /locus_tag="MWG59_RS18455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18455"
                     /product="MobF family relaxase"
                     /protein_id="WP_248585337.1"
                     /transl_table=11
                     /translation="MIGPSDEQVEYRLTGGHGCGKSVAVDAAPLVAAIEAKAEAAGAPV
                     ASLLANREAKRAFFRARGLIRSKGAARFTGFDAVEVAAAAGLDARDLYGEQALPARPAD
                     GQVDYHLDASERPLVWIGSGLTEFDITPGSTLAPEQFPAARRLMLGEDPRTGQTLVDPK
                     LAIAPAAKLPAAPLARAIRRAAAERSVNPTSLLDSKRKQDAFRRMESQLKRFGETHRVP
                     VSTVLKLADAVGINAVDLYGEDTVEKAVAAEAGGHLDARALLRAVEARATETGQEPADL
                     FDAASMKRRYAQTEGEGARRLRDLPMDVREAVAMAKAAGLTPEDVWDAEEIKAALLEGR
                     VQVGNRGADVTLDLAKSKSAFLAYAPEEIAAQVEGIYTAVGRESIGALERWTAYAMRGH
                     HGDGDEAETVKTSGFSGWMMVHRAARPVDGAPYGDPHFHLHFTLANMVKGTDGKWSTMA
                     SGGRDLHRHTRATQSLMNARIRRELTDEFGISFRREERTGAWEIAAIPEATIRLFSKRD
                     SQVRDLLTKLGIDYDSATTRERTAASTASKAAKNGEAAGVGDDVLRAYWQAEGRAAGDD
                     PDAIAASAMEQDRADQNPTLDELCAQVFDPKTGLTSHSKEFTHAAAIAAVLDALPYGVA
                     DAAEAEQLTNSVLRHAGYAVQLNPKGAQHFAHADRYTTADVVAAEALIVSEATNRLGTQ
                     AAAVSSDTVDMTLSTVEAQHGGSFTFSDEQRAVLERLLTAGHGIDAVVGIAGSGKTTIM
                     DTARQAWEAHGLVIAGASTAAVAAANLKAEAGIESRTLASWLTGIRNGGSGLTGVDVLV
                     VDEAAMCDDRDIAELLTHAAETGTKVVGIGDPKQLHSPGIGGSFAAVHHVVGGLTLSQN
                     FRQKDMVERRALELWRDDNRVESLRTFAGTGRVHALADKDATLAAMLTVWADKRAAHTD
                     DHTAVQQLLMLAATNEIVEELNIGARALRKENGDLTGPEHAYALPGGGELTLSVGDQVL
                     LRVNDYRGKKSRGQNDDVLNGYRGIVRAVDEERRVLVEWREKTEDGHRDVAEWVDADYI
                     AQGGLSLGYAITGHKSQGLTVQEALVYGPGAQANALYTMMSRDKKESHLFLPLSVYETD
                     ADRARHGDALTDQEQLDRAVAGLIREIESGTEERMILTELPKNAVPAHIRQAVADLPIP
                     RAPGADEHHDADSPEGAPEHEDRPAPANAGPTMAPATPSGPAPTADRPYAHLSSSALRD
                     AVRKAAIAARATTTAADKAEAAADRAEQEAAAGAGPNSLVLQRRHQDVAERAVAIREVR
                     LLDGTIAERTAQLNGTEARIEGLEQQLAATGRFGRAALRGDERAAVEADRETLLRTREE
                     TVQELEQMDTRLQEATRQAGPVNEHEAVLTEADMPQQEKAALLRRAKAKDNEAAKQLRV
                     EAIKARSTAHGADHRVSGLQKETSLRAQHGRQHVDADESAAPSSPKSDSPYANRTAVDH
                     TQPAPPDSAHDAPPV"
     gene            complement(9190..9441)
                     /locus_tag="MWG59_RS18460"
                     /old_locus_tag="MWG59_18460"
     CDS             complement(9190..9441)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MWG59_RS18460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MWG59_18460"
                     /product="hypothetical protein"
                     /protein_id="WP_248585338.1"
                     /transl_table=11
                     /translation="MLGDQDPDGRRALRIDGVHYLSWTEEQGFAPEIGYVGDGESRYVL
                     LDDPTGTVHVTRRLWLMGTIPDAFRDRMPDNAVFAPPA"
     misc_feature    complement(9539..9552)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.32"
                     /tool="antismash"
     gene            complement(10001..10969)
                     /locus_tag="MWG59_RS18465"
                     /old_locus_tag="MWG59_18465"
     CDS             complement(10001..10969)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662445.1"
                     /locus_tag="MWG59_RS18465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18465"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_349239592.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.4e-35, bitscore:
                     120.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEPTAIQRAVSAALTGLPIPEVAAQYAMEPTILSDAVAVYDQAG
                     REALARHAGATDWWQVYLHFTDWTNADTTFTTHVLPVLREAEAAGLMGGWWYTRKHPCW
                     RLRLRLQPEAGTKLTLGDGFDRLVSDGHLQRWWPGIYEPETAAFGGTVSMTAAHALFVT
                     DSREAQQLRQRGDLAVGPRELSVLLCTIMMRAAGLEWYEQGDVWHRVITEEHRSAVSDV
                     PADRLDARAQEIRPLLFADSDVLLRPGGLLEPVAEWAAAFRSTGQELRRAVQDGTLDRG
                     LRQVLSYHVIFHWNRLGLSMRGQSVLAWAARAAILHQESGT"
     gene            complement(10972..12201)
                     /locus_tag="MWG59_RS18470"
                     /old_locus_tag="MWG59_18470"
     CDS             complement(10972..12201)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018490581.1"
                     /locus_tag="MWG59_RS18470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18470"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_248585339.1"
                     /sec_met_domain="LANC_like (E-value: 4.9e-38, bitscore:
                     129.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPAATTATILEQYTAHLAQPAPPPPDEPWAVQSLADGAAGISL
                     LHIEMASRHGGSWRPAHRWITAAAGGHISAADTAGLFLGAPALGFVLTTVPPTFQHLYE
                     PARRTLHQHITDLTHRRVDAALTRIRKGDLPTFAEYDLFYGLTGIGAYLLRTDPEGLPL
                     ERVLKYLVALTRPLAPDGHGLPGWWVRHDPARGESPHFPGGHGNFGAAHGITGPLLLLA
                     QAMRRGIAVSGHREAIWNICEYLDAWCQLSPSGPWWPEHISRRDLDLGRPHHDAPTRPS
                     WCYGTTGIARAGQLAGLALRAPDVQAFYEDALYRALTDPAQLAHVTDSGLCHGWAGIYQ
                     TTTRAAADARDPRLQTLPKRLGDTLAANAQPNLPDSGLINGVAGTALALTTYASQQAPI
                     SGWDACLLIN"
     gene            complement(12198..15263)
                     /locus_tag="MWG59_RS18475"
                     /old_locus_tag="MWG59_18475"
     CDS             complement(12198..15263)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008746441.1"
                     /locus_tag="MWG59_RS18475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18475"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_248585340.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3.1e-200,
                     bitscore: 665.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 5.5e-17,
                     bitscore: 61.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.5e-11, bitscore:
                     43.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASRAAAGYQWQGVAMLRATTSPGPADIPRTLDLDNVAVTRGWLN
                     RIWQREDFRSALELATPVLSDAIEAVVRGRQTEPRHVRRTALSTVSYLLRWQHRPTPLG
                     LFAGIAPVSVGPRAIARWRDKHRAMIRPDAEWVTDMVLRLQRTPALLKRLPLVANNAVR
                     ARGDRLVAPGPPSDGHAVLLAPVEISVRNARPVAAAMDAARTPIPYGDLHSHLRDRFPQ
                     ATPEKIDALLTSLVEQQFLITSLWAPMTTVDGFQHLCRELDRHQADDVREVRDLVHALY
                     ALRDDVSAHQPTLSDTSVSAVAARMRALTTVTPTPLLIDTALDCETQLPQSVIAEVQAA
                     VSALYRTTPQPYGYQHWRDYHRRFRARYGVGALVPVMDLVADSGLGLPAGYVGSERGAA
                     LKVRTDRDELLLALMQQVLLDGRDELRLTDDMVDALEKAAGEDERLFVPRVEAAFEVHS
                     PSTRALSSGTFDVLLTAVPRPGSSMAGRFAHVLPPEHQDALAATYHGAPDALTAQLVFP
                     PRRHRNENVTRTPRLLPHVIELSGHQETDETTIPLADIAVTADPRSFHLVQLSTGRRID
                     VRVLHALEGGTQTPPLARFLAEVANGRYAAYKPFDFGAGARLPFLPRVRYRRTILTQAR
                     WLLMAADLPGRKASTEEWESAFTAWRDRLRVPMQVAIIEYDQRLPLDLSHPVHRRALRA
                     HLDNARRLELREVPDADAHGWIGRAHEIWLSLGRSQLDTADVPRPRPTTPPTPGRHLPG
                     AGDVLLAQLHAHPRRYDEILSRHLPSLLAAFGDTPPVWWFTRHREMARPDADQHLDVTL
                     HLPPDAYGTAAQHVRTWADSLHGTGLAAGLVLAPYQPQAGRFGSEAAMDAAHQVFAADS
                     AAALAQIQLTERTDAFAPQALAAASALHLVTALAPNNAAAEEWLVRKLPQSTGRLNRAL
                     RTQVLELAAPNGASVLAALPGGPAVAEAWRARAAAVDTYRNALTGQRDPLGVARSLLHQ
                     HHVRALGVDPRAEETTIRLVRTAALQHRMAAR"
     aSDomain        complement(14520..14795)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_MWG59_RS18475_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.00E-19"
                     /identifier="RREFam001.1"
                     /label="MWG59_RS18475"
                     /locus_tag="MWG59_RS18475"
                     /protein_end="248"
                     /protein_start="156"
                     /score="61.1"
                     /tool="antismash"
                     /translation="VANNAVRARGDRLVAPGPPSDGHAVLLAPVEISVRNARPVAAAMD
                     AARTPIPYGDLHSHLRDRFPQATPEKIDALLTSLVEQQFLITSLWAP"
     misc_feature    complement(14802..14804)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     assembly_gap    15307..15316
                     /estimated_length=10
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            complement(15342..15545)
                     /gene="fxlA"
                     /locus_tag="MWG59_RS18480"
                     /old_locus_tag="MWG59_18480"
     CDS             complement(15342..15545)
                     /codon_start=1
                     /gene="fxlA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380187.1"
                     /locus_tag="MWG59_RS18480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18480"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_248585341.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 2.4e-14, bitscore:
                     51.8, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSATLAPPPVAPAPLAGLDDDFAPLDVKVVIAEHSYGHLMCSTG
                     DGCGTTCATGASACGSFTEDPA"
     gene            complement(15596..16834)
                     /gene="fxlM"
                     /locus_tag="MWG59_RS18485"
                     /old_locus_tag="MWG59_18485"
     CDS             complement(15596..16834)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018490583.1"
                     /locus_tag="MWG59_RS18485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18485"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_248585342.1"
                     /sec_met_domain="PCMT (E-value: 3.3e-36, bitscore: 123.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNTTVEPDEATRLRNKVVDELCADGNISSPEVEAVMRKVLRHEF
                     TPADTPLDKAYDTYAAVITKTDEHGVQLSSVSAPQIQAMMLEQAQVKPGMRVLEIGSGG
                     LNAAYLAELVGEDGEVVTVDIDPVVTDRARRLLDKHGYGRVHVVTADAAEPIPDLGEVD
                     VVMVTAGAWDVSPAWTAQLKEGGRLVVPLRMRGLTRSVAFIQVKGEHGPYLESESAKIC
                     GFVPMQGSTAHREELLLVNGTPEIGLKFDDGLPADPHRLDNAVTFPRHELWTGVTVRIQ
                     ELIDTLQMAMAISLPGFCTMAVDENSDTGVVDPVNKRFALAAVEDDTFAYLVTRRTEDN
                     KHLEYGVHALGPHAKQFADEIAGVLRDWEANRRGGPSPVIRVYPASTPDDQIPADRVID
                     KVHSRISLSWPSA"
     gene            complement(17038..17685)
                     /locus_tag="MWG59_RS18490"
                     /old_locus_tag="MWG59_18490"
     CDS             complement(17038..17685)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143560.1"
                     /locus_tag="MWG59_RS18490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18490"
                     /product="hypothetical protein"
                     /protein_id="WP_248585343.1"
                     /transl_table=11
                     /translation="MTTAPEAVVPYITAREGEEADSFLNLRMGRGPDGRPRLRYVDELP
                     PDRDLKDVLWARYSMSLDTFGQPCGTPRWRMVHPHRQRVTMALLRCQVCTVQLKRTDGI
                     LFLETAGEEGYDGPVKTAQPPVCLEHARMAASRCPRLRARGHVALLATRFPLYGVIGHA
                     YQWSANGLQALSDMDSPIPYRHPQIGMFLASQLVRELREYKVVNLDDLVPAA"
     gene            complement(17682..17885)
                     /locus_tag="MWG59_RS18495"
                     /old_locus_tag="MWG59_18495"
     CDS             complement(17682..17885)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020140274.1"
                     /locus_tag="MWG59_RS18495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18495"
                     /product="DUF5999 family protein"
                     /protein_id="WP_248585344.1"
                     /transl_table=11
                     /translation="MCQHTPPCPTAEASDREAARPTAAHPEQGWSLLCNGVLLFEDTGE
                     LLPDGQIVAPHRPVALAAGSTA"
     gene            complement(17939..18373)
                     /locus_tag="MWG59_RS18500"
                     /old_locus_tag="MWG59_18500"
     CDS             complement(17939..18373)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008746446.1"
                     /locus_tag="MWG59_RS18500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18500"
                     /product="DUF6302 family protein"
                     /protein_id="WP_248585345.1"
                     /transl_table=11
                     /translation="MTTTVIALPQDAYDFDYFEQRISDTWLLDKSIAVRTLRMPFLAVP
                     VGGTRRGGYYPVSCLCFGFKVRDLLLEQPGFPDLRVRWSPYRDTCHTVEWGDPAPEWWE
                     DDAVFGRFYGYSESAITSFLRERPQTPSSATSTPCSPTAS"
     gene            complement(18406..18858)
                     /locus_tag="MWG59_RS18505"
                     /old_locus_tag="MWG59_18505"
     CDS             complement(18406..18858)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008746447.1"
                     /locus_tag="MWG59_RS18505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18505"
                     /product="DUF6415 family natural product biosynthesis
                     protein"
                     /protein_id="WP_248585346.1"
                     /transl_table=11
                     /translation="MSLTVLVPENDVVPPPFDAPSTAQWAPPLDAEGLRFVLERIKDWK
                     PFDVEEVFDDLDMAIGNQPPPVATTSALIDRLRGHLKQLSDITVADAKYPPTEEMVRLV
                     ERGHALREEHTPADQQRAVGLARRLAFVASDLVQELIEARYIKGAE"
     gene            complement(18897..19370)
                     /locus_tag="MWG59_RS18510"
                     /old_locus_tag="MWG59_18510"
     CDS             complement(18897..19370)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.4"
                     /locus_tag="MWG59_RS18510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18510"
                     /product="ATP-binding protein"
                     /protein_id="WP_248585347.1"
                     /transl_table=11
                     /translation="MELLVDTRERDASVRAMSRSVGGQLDMSFDVRAEDLGTVRDIVAA
                     HLCWWRIDNGTAHRMLTVVNELLTNVLQHTPANDDGCRMASLLLQKVPDGVTAVVSDQD
                     PCPPVYTSPDSLAEEGRGLMLLRALADDTSVSVTPAGKDVWVFIGTPEATEHF"
     gene            19546..20937
                     /locus_tag="MWG59_RS18515"
                     /old_locus_tag="MWG59_18515"
     CDS             19546..20937
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031332.1"
                     /locus_tag="MWG59_RS18515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18515"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_248585348.1"
                     /transl_table=11
                     /translation="MKQLDPGASPQEWFGNELRRLRLEQGLSAKDLGRLVQVSDDMILS
                     IEKGKYPSCRRDVVQRLDDVLRTGGLLDRAWPMAFGNRDADRKRADADNASTRRGEERV
                     QAPTGPILGRDEPTLRPGSHEPVIRRSFLQIGGLAAIAPLDLADVFAPSELSLPTTVNP
                     PHIDQVLAAATAISGMDNELGGGGMVRDVASRAMQWSAGLLQAQCPEHLRTELFAAVSR
                     LGIVVGASAFDAYHHDEATQTFRFAADCAEEAGHWHLRAKTYSFLARQAVWIGTPDDGL
                     TYAEKGLVRSDRLTATEQAMLHTARARAFGKMGNVRDTMAAVGAADEAFTRARPAEDSP
                     WMAYYDEAQHNGDTAHALFDLAILAGQDPGRAARRFDTAVKGHTDAYKRSRAISRTKLA
                     SLIMVKGDPRQAATLGHDALDEVGRLTSRRAADDLRQLGRFASKHRAIPEASGLRDRIA
                     ATVSA"
     misc_feature    19648..19650
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            20934..21821
                     /locus_tag="MWG59_RS18520"
                     /old_locus_tag="MWG59_18520"
     CDS             20934..21821
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008746450.1"
                     /locus_tag="MWG59_RS18520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18520"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_248585349.1"
                     /sec_met_domain="APH (E-value: 3.2e-19, bitscore: 68.6,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNSAAAPARHVLEQACSAAGLDSAGAEPLRLAENEIWRLPGQRV
                     IVRIAREGQSAAAAREVRVARWLAQEDIAAVRLVDVEQPVEAGGRPVTFWVELPPQEHG
                     SVEDVAQVLLQLHSLATPDIELGYLDPFVRVGERLEAASTIRDEDREWLHGLHRDLAAA
                     WAERPAGLPDRAVHGDAWPGNIVRTIDGALMMDLERFSVGPPEWDLVSTAVRAKTTGAV
                     STREYDQFCAVYGHDVTMWEGYPILARARELRMVTYAAQHAANNPEWSSQAQYRIDCLR
                     GRSGPRPWAWKGIL"
     misc_feature    21051..21053
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(22924..23427)
                     /locus_tag="MWG59_RS18525"
                     /old_locus_tag="MWG59_18525"
     CDS             complement(22924..23427)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447313.1"
                     /locus_tag="MWG59_RS18525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18525"
                     /product="hypothetical protein"
                     /protein_id="WP_248585350.1"
                     /transl_table=11
                     /translation="MTETLTHFEPFPEPPALILEYIAERSTEESVAADGPAPWDIGALS
                     AELIAPMPAWLDSVCRWLNRTYAWQPQDVIPPCWAKHESLAYEIAALAFAREDAYTEAG
                     SSVIWHEQYDRFLTRMNKTLGKAGDECRVGKHDERPARFQLAAWPTAKGEETASAGRVE
                     EMAG"
     gene            complement(23424..24872)
                     /locus_tag="MWG59_RS18530"
                     /old_locus_tag="MWG59_18530"
     CDS             complement(23424..24872)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447312.1"
                     /locus_tag="MWG59_RS18530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MWG59_18530"
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_248585351.1"
                     /transl_table=11
                     /translation="MHHPLDPHDFGYSLGTSQRPKGVELWSRADKACRVIGPMGSGKTL
                     RFFAPLVRRWAGPVLATSTKPDLVELTLDARQRDGRPVAVFDPQNIAPSLPRFRWTPIN
                     GATDTEVAMMRGKAFVAGSRTPNGAAQSSEGSAFYKGQASKILAAFFHAAALDGASLDW
                     VLRWARKLTDPAPLGILNAHPGAGPGWADMLRTATTGDSRTVGNTASTLDAALEPFMHQ
                     SVINALQGDGEDPTDFGAFLDAGGTLYLLGKDSEVNSVAPLTTAIAEDLLDFAEAHALA
                     SPAGRLDPALLAALDEAPNIAPIPSLRQRVADGRGRGITVVYGLQAWASARARFGEDTA
                     KELAAFTNNVIVLPGDKDPDFLKDMSDLCGQVERERTTKTTSGGDRGGHSTATHMALEP
                     VLRGDEIRGLPEGHALVLADNLPPIVSRLDGMWTWDSWPEIEGHVRDLRAANEAERTRR
                     ATEKKNQAKAHAVAWAGREGAAAA"
     gene            complement(24916..25179)
                     /locus_tag="MWG59_RS18535"
                     /old_locus_tag="MWG59_18535"
     CDS             complement(24916..25179)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MWG59_RS18535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MWG59_18535"
                     /product="hypothetical protein"
                     /protein_id="WP_248585352.1"
                     /transl_table=11
                     /translation="MDIMPGGISLALYAVTAVCAIALVTLWFLVNRGRRNAGFASKGQL
                     KRQMSAKAVLKATEIRPSLTSDDRHPSRATGVSFAKDRPAAR"
     misc_feature    complement(25148..25161)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.22"
                     /tool="antismash"
ORIGIN
        1 cggtaaccag cacgacgact ggacttggac cgccccctac gacgacgtgt ccgggcgcaa
       61 gagcgccgac gagatgcagc cgccccaggc agaggccgcc gaacagcagg agcaggccga
      121 gcagtccacg ccgaccgagg agccggtacc ggcggagaag ccgaccccgg tggcggtgcc
      181 cgccccaggt gcgaactggc aggacggcat ggcgctggtg ctgatcgcct cgaagaactc
      241 ccgccgctcc cgcaagcgtg ccttgtgggc gatgacccgc cgcgaggcac aggccgtgtg
      301 cggcgacccc cgtacctccg gacgctcgta catgctcacc tggaccgacc ggcccggcat
      361 cgaaggtgcc gactgggaat ggacgcctga caacggaagt ctcgacccgg tcctttcgga
      421 cctgggcgtc actccgcgcc gtgaatggac cgccgccacg caggcccccg ccgaggccgc
      481 gtaaccacgc ccccgcccgc cccggcggcc gagcgcnnnn nnnnnngggg cgggcccctc
      541 tctcaccaga acagggcacc accatgacca cgcaactcct cgaacgaccc acgaccgtca
      601 ccgtccccga caccacaggg ggcaggctca tcgtcccctc gacccacggc accaccaccg
      661 tcccggcgta ccgcgtcggc gcccccgaca tccaatgccg ctaccccgtg atcgttggcg
      721 aagaccaggt catcggccgc gcctaccggt ggcaccgtga ctggctcgtc ctcaccaccg
      781 tgggtgaaca caacctccgt cgcccgccga agggaacacc gggcaccgag atggccgccg
      841 cccatctcgc cgagcagtac gccgccggtc ggatcgacgc agtccccctg gaccaggtac
      901 tcgccgaggc ccccaccccg ctgtgcgggc cggtgcctct cctgcacccc cggatgccgg
      961 tcaacgatcg caacatcgag ggcgcgctga tcgcgttcgc agggctccgg gcccaccact
     1021 ggcgggcagt cctcaccggg tttcccggca gcgataacca ctggtacctc agctgcgaat
     1081 tgtgcccgtg ggagggcccg aagttctggt cgcacttgcg cgggcgcaac ggagagccgc
     1141 cgagcgcgcg ccgtcacaag ggcgggtgca tcggagagga aaaggtccgc cggttgatcc
     1201 ccgcctacca ctagcagccc caccgggggn nnnnnnnnnc ccccgctctc tggaaggaca
     1261 ccgccgtgcc gacccgtcac acccccgaaa gcatcgtcat cgcggacacc cccgccgcga
     1321 tcctggaatg ggccgcccgc cacatcgaac acgtcggcat ccaccagggc ccacacctgt
     1381 tcgccggtcc cggccgtacg gccaccctgc cgtgctggcc gcgtggcgcc ctccaagtcg
     1441 ccgccggcca cgggcgaggg gccgccggcc gaacgtacga ctgggaccgc atcaaccgcg
     1501 cccgcgacca ggcgttcggc atcctcgcgg aaaccctcac cggtcacccc gtcgacgccg
     1561 atgatcccgc aaccgccaac gcccggcacc gcgaggccat cgaccggtgg agcgccgatc
     1621 ccggccgcac cgccgccgac gccgcccacg cgttccgcac cgccgctgcc cgcgccgaac
     1681 acgccctgtt ctgacagacc ccgccagcat cccgagtcat cgaaggccag cacgatggac
     1741 gagacgacag cttcccgcag caccacccgg acgccgaccc gccgaggagc cgccaccccc
     1801 agccgggacg gtgtccaccg gctcagcgtc cccctccacc cccggctcag cgcaaccgag
     1861 ctgatccgcg tcctcctcgc ggccccgggg gaaaacgacc tcaccgccct tgacccggta
     1921 caggtccggt cgctcatcgc cgatgtgctc acccagcacg gctatgacgt gctcgaccga
     1981 tcgccgtact acccggaact cgaccgccac caggacgccc gccgtgccgt gcgccgtgcg
     2041 tacgggccgc ggttcctcga cgcccccgac gaacaggccg tgctcgctga cccactccgc
     2101 gaagtgctcg ccgccggaag caggaagtcg tgaccgttcc cgccgccgag ccgactggag
     2161 cacgggcacg gcagacgtac tactggcggg tgcgcaacgc acggacgcgg caccgccccg
     2221 agagcgcggg acaggcgtgg cacatccagc ccggacaccc cggcggcgcg tactgcgacc
     2281 tcggccacga cctggacccg cccgcacacc acaccccaac ccttctctcc cgcagccggc
     2341 cgaccggccg ctggggagac gggcaggaat ttcggggcgg gtgtctcgcg tgcgagtggg
     2401 aaggccccgt ccattgcgga ggcgggttcg gggacggtga caacgaggcc gtggaggacg
     2461 cccacgacca cgcgttcccc ggctggcgga cactgcctcc gatcaccgcg gtcgaggaca
     2521 gatgggccgt tccgcggagc cgaagccgct gggctcagct cactgccccg tacccggcgg
     2581 gatgggtgga ccagggcgcc cccgtcgtgg cctggaggcg gtaccgccgc gaagcccacc
     2641 ttccgccaca cgccggacgc ccccgctacg aactccgcat cacccggcca ccgcgcgacc
     2701 gggcccgacg ccccgcagat caggacgccc tcttctgatg cccgccgtcc ttcggatcag
     2761 ggccccaccc gctcaaccta aaggtggttt aattacttcg gcatcagcgg agcgggcaac
     2821 ctccgaccgg ccgcgcgttc cacaggacgc cacgcaccca gacaacagac gacggccagc
     2881 gcacaagggc aacaaggcgc tggccgtcag tgtctctcac cagaaagacc acaccatgct
     2941 atgtgaccga caccccgact gtccccagcc cggcgacatc gcccagctca ccaggggtaa
     3001 cagcatcggc gccgatcccg gcgagagctt cgtcatcgtc gaggacttcc ccccgaccgg
     3061 ccgccacctc gtgctcaacc tgcccgtcga ccaccccggc cgcgccgact gggccgccgc
     3121 cgtccccccg gccgacatag ccaccctcac ccggctcgaa ccggcaggca gccgtacgtg
     3181 gacgccggcc ccggacccgg acgagatcca atgaccgcgc tgagcggtca cgaccccgac
     3241 catgaacagg agacgaccgt gtcccccaag accggccgca cgctctactc acgcgcagac
     3301 ctgcgcaagg tccacggcat tagcgaaccc acgcttcaaa acctctggac cgaccgggag
     3361 aacaacgggc acccgcccgt cgaggagacc atcgacggcg tcatgcactg ggacggcgac
     3421 gtatgggcga cgtggcacca cgagcttcag cggcagcgcg ccgcagccag caccaccaac
     3481 ccgccgaagc tcgacggcga ccccgaagag atggtcggcc cggcggaagc cgcgaaggtc
     3541 tgcggtttcg ccgactcgac caccgtctcc cactacgtca agaacccgcc cgaggggtgg
     3601 ccggcgccgg acgactggga cgagcttccg acccggcgcc gcccgaagtg gaagcgctgg
     3661 aggctgtggc agtacctcgc ggaccgcaag ggccgcggcc acgccggcgg acggcccacc
     3721 ggtcgccgcg gactggccta cccctaccag ggcgacgagc ggctgaccct cgcccggcag
     3781 gccatcgcgg cgaatcccgg cgcgaagaac gccgaactga tccccgaact ccagaagcag
     3841 acggagaaga cctactcacg cccgacctgg aatctgatcc tcaagtccgc ccgcgagaac
     3901 cccgaggagt gacccgtgcc cgacacccgc tgtccgcgct gcggcggccc gctcggtgaa
     3961 cggcccgcac gttcccggct gaccgccgcc cgcgaggtcc ccatctgcac cacgtgcggt
     4021 acggaggaag ccgtgcgcga agcccaaggc caggcgccgg tgccgttcgg cgagtggccc
     4081 ctgaacacgt aaccgtcggc caagaggtca ttcggcgaac atgacgaagg tccccgctcc
     4141 agatcggagc ggggaccttc gtcatgtcac ccggcgctgg ccggtcgggc agggctcaac
     4201 cagaccgctc gcccccgcag aaggagcgac ggatcagtgg ctacgagccc tccgccggcc
     4261 ggggcgcgct ccgccctgcg gccgatcgct tggtgcaggg ggtgaagtct tacgtcccgg
     4321 cccgaactgg tcctccgcgc cgggcctgga cgccgggaag tccgaagcca tccagtacgg
     4381 gcccgacact cggcgaaccg gcgggatgcc gctggatgcg gggtctgctc catacgcgga
     4441 ccaacgactc agcgccgcgt aggcacctca ccgacatcgg attgtcatgc cgcctcagca
     4501 cgtacgacac cccagcccgc gcacctcgca cagaggtaac agtccaacag gacatcaggc
     4561 tccaggagcc tgatccgcag gaggaacgag gctgatccga gtgcccgaaa tcctcgtcgt
     4621 tgatcatgat cttgaattta gaggaccaag gtatcgtcac ttcgtgacga tacaatcagc
     4681 caagacgacc gaatctgacc ggatgagagc ggggggtgag cgggccggtg ggatgggtga
     4741 ccatgatcgg cccgtccgac gagcaggttg agtaccgcct caccggcggc cacggatgcg
     4801 ggaagtccgt agcggtcgac gctgcccctc tcgtcgccgc catcgaggcc aaggccgaag
     4861 ccgctggtgc ccccgtcgcc tccctgctcg cgaaccgaga ggccaagcgc gccttcttcc
     4921 gcgcccgcgg actcatccgc agcaaaggcg ctgcgaggtt caccgggttc gacgccgttg
     4981 aagtcgccgc cgcagccggg ctcgacgccc gcgacctcta cggtgaacag gccctccccg
     5041 ctcggcccgc ggacggacag gtggactacc acctggacgc cagcgaaagg cccctggtct
     5101 ggatcggcag cgggctcacc gagttcgaca tcacgcccgg cagcaccctc gcccccgagc
     5161 agttcccggc cgcccggcgc ctcatgctcg gggaggaccc ccggaccggt cagaccctcg
     5221 tggaccccaa gctggccatc gcgccggccg ccaagctccc cgccgcccca ctggcccgcg
     5281 ccatccgccg cgccgccgcc gaacgcagcg tgaacccgac ctccctgctc gactccaagc
     5341 gcaagcagga cgccttccgc cggatggaga gccagctcaa gcggttcggc gagacgcacc
     5401 gcgtccctgt ctccacggtg ctgaagctcg ccgacgccgt cggcatcaac gccgtcgacc
     5461 tctacggtga ggacacggtg gagaaggccg tcgccgccga ggcgggcggc cacctggacg
     5521 cccgtgcact cctgcgcgcg gtcgaggccc gcgccaccga gaccggccag gagcccgccg
     5581 acctgttcga cgccgcgtcc atgaagcgcc ggtacgccca gaccgaaggc gaaggcgcac
     5641 gtcgtcttcg ggatctgccg atggacgtgc gggaagccgt cgcgatggcc aaggcggcag
     5701 ggctcacgcc ggaggacgtg tgggacgccg aggagatcaa ggccgccctc ctcgaaggcc
     5761 gtgtgcaagt cggcaatcgc ggtgctgacg tcaccttgga cttggcgaag tcgaagtctg
     5821 cgttccttgc gtacgcgccc gaggagatcg ccgcccaggt cgagggcatc tacacggccg
     5881 tcggccggga gtccatcggc gccctggagc ggtggaccgc gtacgccatg cgcggccacc
     5941 acggcgacgg tgacgaagcg gagaccgtga agacgagcgg gttctccggc tggatgatgg
     6001 tccaccgcgc cgcccgcccc gtcgacggtg ccccgtacgg agacccccac ttccacctgc
     6061 acttcaccct ggccaacatg gtcaagggca ccgacggtaa gtggtccacg atggccagcg
     6121 ggggccgcga cctccaccgg cacacccgcg cgacccagtc cctcatgaat gcccgcatcc
     6181 gccgcgagct gaccgacgag ttcggcatca gcttccgccg agaggaacgg accggagcct
     6241 gggaaatcgc agcgattccc gaggccacga tccggctctt cagcaagcgc gacagccagg
     6301 tccgggacct gctgacgaaa ctcggcatcg actacgacag cgccacgacc cgcgagcgca
     6361 ccgccgcctc caccgcgtcc aaggccgcga agaacggcga ggccgccggg gtcggggacg
     6421 atgttctccg cgcctactgg caggccgaag gccgtgcggc cggagacgac cccgacgcga
     6481 tcgcagccag cgcgatggaa caggaccgag cagaccagaa ccccaccctg gacgagctgt
     6541 gcgcccaggt cttcgacccc aagaccggct tgaccagcca ctccaaggag ttcacccacg
     6601 ccgccgccat cgccgccgtg ctggacgccc tcccgtacgg cgtcgcggac gccgccgagg
     6661 ccgaacagct caccaactcc gtactccggc acgccggata cgcggtccag ctcaacccga
     6721 agggtgccca gcacttcgcg cacgccgacc ggtacaccac ggcggatgtc gtggcggccg
     6781 aagcgctgat cgtctctgag gccacgaacc ggctcggcac tcaggccgcc gccgtcagca
     6841 gcgacacggt cgacatgacg ctgtccaccg tcgaggctca gcacggcggc agcttcacgt
     6901 tctccgacga acagcgtgcc gtcctcgaac ggctgctcac ggccgggcac ggaatcgacg
     6961 ccgtcgtggg catcgccggg tcgggcaaga ccacgatcat ggacaccgcg cgccaggcat
     7021 gggaggcgca cggtctcgtc atcgccggcg cgagtacggc cgccgtcgcc gccgcgaacc
     7081 tgaaggccga ggcgggcatc gagtcccgaa ccctcgcgtc ctggttgacc ggcatccgca
     7141 acggaggctc cggcctcacc ggcgtggacg tgttggtcgt ggacgaagcc gccatgtgcg
     7201 atgaccgcga catcgccgaa ctcctcaccc acgccgcgga aaccggcacg aaggtcgtcg
     7261 gtatcggtga ccccaagcag ctccactcgc ccggcatcgg cggcagcttc gccgccgtgc
     7321 accacgtcgt gggcgggctc accctcagcc agaatttccg ccagaaggac atggtcgagc
     7381 gccgggccct ggagctgtgg cgcgacgaca accgcgtgga atcgctccgt accttcgccg
     7441 ggaccggtcg cgtgcacgct ctcgcggaca aggacgccac cctcgccgcg atgctcaccg
     7501 tctgggccga caagcgggcc gcgcacaccg acgaccacac cgccgtgcag cagctcctca
     7561 tgctcgccgc caccaacgag atcgtggaag agctgaatat cggcgcccgc gcactgcgga
     7621 aggagaacgg cgacctcacc ggtcccgagc acgcatacgc gctgcccggt ggcggcgagc
     7681 tgaccctgtc cgtcggtgac caggttctcc tacgggtcaa cgactaccgg ggtaagaaga
     7741 gccgagggca gaacgacgac gtcctgaacg gctaccgcgg aatcgtgcgc gccgtggacg
     7801 aggaacgccg ggtgctggtc gagtggcggg aaaagaccga ggacggccac cgtgacgttg
     7861 ccgaatgggt ggacgccgac tacatcgcac agggcgggct cagcctcgga tacgcgatca
     7921 ccggccacaa gtcgcagggc ctcaccgtcc aagaggctct ggtctacgga cccggcgctc
     7981 aggcgaacgc cctctacacg atgatgagcc gcgacaagaa ggagtcccac ctcttcctgc
     8041 cgctctccgt ctacgagacc gacgccgacc gcgcccgcca cggcgacgca ctcaccgacc
     8101 aggaacagct tgaccgcgcc gtcgcgggcc tcatccgcga gatcgagagc ggcaccgagg
     8161 aacgcatgat cctcaccgaa ctcccgaaga acgcggtccc tgcccacatc cgccaggccg
     8221 tagcggacct cccgatcccg cgcgcccctg gcgccgacga gcaccacgac gcagacagtc
     8281 ccgaaggggc tccggagcac gaggaccgcc ccgcaccggc gaacgccggg ccgaccatgg
     8341 cgccggccac accttcggga cccgcgccga cggctgaccg tccatacgct cacctcagta
     8401 gctcggcact gcgtgacgcc gtgcgcaagg ccgccatcgc tgcccgcgcc acaacgacgg
     8461 cggccgacaa agcggaagcc gccgccgatc gtgccgaaca ggaggccgct gccggtgcag
     8521 gccccaattc actcgtgctc caacgccgtc accaggacgt tgccgaacgg gccgtggcca
     8581 tccgcgaagt ccggctgctg gacggcacca tcgcggaacg caccgctcaa ctgaacggca
     8641 ccgaggcccg tatcgaaggt cttgaacagc agctggccgc gacgggccgt tttgggaggg
     8701 cggcactccg cggtgacgaa cgtgctgcgg tcgaggcgga ccgggaaacc ctccttcgta
     8761 cccgtgagga gactgtccag gagctggagc agatggacac gcggctccag gaagctaccc
     8821 ggcaggccgg acccgtcaac gagcacgaag ctgtgctgac ggaagcggac atgccgcagc
     8881 aggagaaggc cgcgctgctt cggcgggcca aggccaagga caacgaggca gccaagcagc
     8941 tccgggtcga ggccatcaag gctcgcagca ctgctcacgg cgcagaccac cgcgtgtccg
     9001 gcctccagaa ggagacgagt ctgcgagccc agcacggacg tcagcacgtc gatgccgatg
     9061 agtccgcggc gccctcatct ccgaagtccg actccccgta cgccaaccga accgcggtgg
     9121 accacacaca gcccgcaccg ccggacagcg ctcacgacgc accgcccgtg taagaagcgg
     9181 cctacctttc taggctggcg gagcgaagac cgcgttgtcc ggcatccggt cgcggaacgc
     9241 atccgggatg gtgcccatga gccagaggcg gcgcgtcacg tgcacggtgc ctgtcgggtc
     9301 gtcgagcagg acgtagcggg actccccgtc ccctacgtag ccgatctccg gcgcgaaccc
     9361 ctgctcctcg gtccacgaca ggtaatggac gccgtcgatc cggagggcac gccgtccgtc
     9421 cgggtcttgg tcgccaagca tcgcgtaccc caggcacatc agccagaagt cacacgagct
     9481 gcatacccga tacgcagcca tccgagcgcc gacacctcgg atctcccggt ccgtcccctt
     9541 gttcgggcac aacttgcact gaaacagctg gtacacctcg ggtgtacggg cccgcctcat
     9601 gcgccggagg cggcgggccc gcgccggaca tgcttgcacc ggacaccgcg ctcgatgtcc
     9661 tggagcgagg gtttacggga cgccccgcag tcggtgcact cgctcggcca aggcatcgag
     9721 cggcaccggg gtaaggcccc ttcggctcgt agccggccgc acgcatcacc tccgtggcct
     9781 cccgctcatc ggcggttacc tggggggtgg gcgggggccc agagacgggc ggcgggagct
     9841 cgaagctctg tgggtgtccc ccgaatagca atccgaggct cacccattgc ttgtgccgcg
     9901 atggaacggt catggcaagt cctatctcgc acgactatgg gtcgcttggc ctgggcctcc
     9961 agctagtggc cccctgcggt tcatacggct cgcggccgac ctatgtcccg ctttcctggt
    10021 gcaggattgc cgccctcgct gcccaggcca agacgctctg tccccgcatg gacagcccaa
    10081 gccggttcca gtgaaagatc acgtgatagc tgagcacctg cctcagccct cggtcgagcg
    10141 tcccgtcctg tacggcacgg cggagttcct gccccgtgct acggaaggcg gcggcccact
    10201 cggcgacggg ttccaacagc ccgccggggc gcagcaggac atcactgtcg gcgaagagca
    10261 gcggccggat ctcctgtgcg cgggcgtcga gccggtctgc cgggacgtcg ctgacggccg
    10321 atcggtgttc ttccgtgatg acgcggtgcc acacgtcccc ttgctcgtac cactccaggc
    10381 ccgcggcgcg catcatgatc gtgcagagga gaacggacag ctcccgcggt cccacggcta
    10441 ggtccccgcg ctgccttagt tgctgcgcct ctcggctgtc ggtgacgaac agcgcgtgcg
    10501 cggccgtcat gctgaccgtg cccccgaacg ctgcggtctc cggctcgtag atcccgggcc
    10561 accaccgttg cagatgcccg tcggagacga gacggtcgaa gccgtcgccg agtgtcagtt
    10621 tggttccggc ctcgggctgt agacgaaggc gcaggcgcca gcacgggtgc ttgcgggtgt
    10681 accaccagcc acccatgagc cccgcagcct ctgcctcccg aagcacgggg agcacgtgcg
    10741 tggtgaaggt ggtgtcggcg ttcgtccagt cggtgaaatg gaggtacacc tgccaccagt
    10801 cggtggcccc tgcgtggcgg gccagggcct cccggccagc ttggtcgtag accgccacgg
    10861 cgtcggacag gatcgtcggt tccatcgcgt actgggctgc gacctcgggg atcggcaggc
    10921 cggtgagggc agcggagacc gcgcgctgga tcgcggtcgg ctccgtcaag atcagttgat
    10981 caagagacat gcgtcccatc cggagatcgg ggcctgctgt gaggcgtagg tggtgagggc
    11041 gagcgcggta ccggcgacgc cgttgatcag gccggagtcg ggaaggttcg gctgggcgtt
    11101 cgctgcgagg gtgtcgccga ggcgcttcgg gagggtctga agtcgggggt cgcgggcatc
    11161 ggcggcggcg cgggtggtgg tctggtagat gcctgcccag ccgtggcaca ggccggagtc
    11221 ggtgacgtgg gcgagctgtg cggggtcggt cagggcgcgg tacagggcgt cctcgtagaa
    11281 cgcttggacg tcgggggcgc gcagggcgag cccggcgagt tgcccggctc gtgcgatgcc
    11341 cgtggttccg tagcaccagc tcggccgggt gggagcgtcg tggtgcgggc gcccgaggtc
    11401 gaggtcgcgg cgggagatgt gctcgggcca ccagggaccg gagggactga gctggcacca
    11461 ggcgtcaagg tattcgcaga tgttccagat ggcttcgcgg tggccgctga cggcgatgcc
    11521 gcggcgcatg gcctgggcca gcaggagaag cggaccggtg atgccgtggg ctgcaccgaa
    11581 gttgccgtgg ccgcccggga agtgggggga ctcgccacgg gccgggtcgt ggcggaccca
    11641 ccagcccggc aggccgtggc cgtcgggggc gagggggcgg gtcagggcaa cgaggtactt
    11701 caggacccgt tccaggggga gcccttcggg gtcggtccga aggaggtagg ccccgatgcc
    11761 ggtgaggccg tagaacaggt cgtactcggc gaacgtgggc aggtcgccct tgcggatgcg
    11821 ggtgagcgcg gcgtccacgc ggcggtgggt caggtcggtg atgtgctggt gcagggtccg
    11881 gcgcgccggt tcgtacaggt gctggaaggt cggcgggacg gtggtgagga cgaagccgag
    11941 ggccggggcg ccgaggaaca gtccggcggt gtcggccgcg ctgatgtgcc cgcccgctgc
    12001 ggcggtgatc caccggtggg cggggcgcca ggaaccgccg tgacggctgg ccatctcgat
    12061 gtgcagcagg ctgattccgg cggcgccgtc ggcgagggac tgcaccgccc aaggctcgtc
    12121 cgggggcggc ggagcgggtt gtgcgaggtg ggcggtgtac tgctccagga tcgtcgcggt
    12181 ggtggcagcc ggcgcggtca tcgggcggcc atcctgtgct ggagggccgc ggttcgtacg
    12241 agccggatcg tggtctcctc ggcgcgcggg tcgacgccca gggcccggac gtggtgctgg
    12301 tgcaggagag accgggcgac gccgagggga tcacgctggc cggtcaaggc gttccggtag
    12361 gtgtccacgg cggcggcgcg ggcccgccat gcttcggcga ccgcagggcc gccggggagg
    12421 gccgcgagca cggaggcgcc gttcggcgcg gcgagttcga gcacctgggt acgcagggcc
    12481 cggttcagtc gccccgtgct ctgggggagt ttgcgcacca accactcctc ggccgccgcg
    12541 ttgttcggcg ccagggcggt gacgaggtgc agggcgctgg cagcggcgag ggcctgcggg
    12601 gcgaaggcgt cagtgcgctc ggtgagctgg atctgcgcga gggcggcggc ggagtctgcg
    12661 gcgaacacct ggtgcgcggc gtccatggct gcctcgctgc cgaagcgccc ggcctgcggc
    12721 tggtagggag ccaggacgag cccggccgcc agaccggtgc cgtgcaggct gtccgcccag
    12781 gtacgaacgt gttgggcggc ggtcccgtat gcgtccggcg gcaggtgcag cgtgacgtcg
    12841 aggtgctggt cggcgtccgg gcgagccatc tcccggtgcc gggtgaacca ccagaccggc
    12901 ggggtgtcgc cgaacgcggc gaggaggctg ggcaggtggc ggctcaggat ctcgtcgtag
    12961 cggcgcgggt gggcgtggag ctgcgcgagc aggacgtcac cggcgcccgg aaggtgccgc
    13021 ccgggggtgg gcggggtggt ggggcgcggc cgtggcacat cggcggtgtc cagctgcgac
    13081 cggcccagag agagccagat ctcgtgtgcc cgtccgatcc agccgtgggc gtctgcgtcc
    13141 gggacttcgc gcagctcaag acgccgggcg ttgtcgaggt gggcgcgtag ggcccggcgg
    13201 tggaccggat gggacaggtc gagggggagg cgttggtcgt actcgatgat ggcgacctgc
    13261 atggggaccc gcagtcggtc ccgccaggcg gtgaaggcgc tctcccactc ctcggtcgag
    13321 gctttgcggc cgggcaggtc ggcggccatc agcaaccatc gggcctgcgt gaggatggtg
    13381 cggcggtagc gcacgcgcgg gaggaacggg agccgagcgc cagcgccgaa gtcgaacggc
    13441 ttgtaggcgg cgtaccgccc gttggccact tcggcgagga accgggccag tggtggtgtc
    13501 tgtgtcccgc cttccagggc gtgcagaacc cgcacgtcga tgcgccggcc ggtggagagc
    13561 tgcacgaggt ggaagctgcg cgggtccgcg gtgacggcga tgtcagcgag agggatcgtc
    13621 gtctcgtccg tctcctggtg gccggacagc tcgatgacgt gcggcagcag ccgcggcgta
    13681 cgggtgacgt tctcgttgcg gtggcggcgc ggcgggaaca cgagctgcgc tgtgagggcg
    13741 tccggcgccc cgtggtacgt ggcggcgagc gcgtcctgat gctcgggcgg caggacgtgg
    13801 gcaaaccggc cggccatgct gctgccgggg cggggaactg cggtgaggag gacatcgaag
    13861 gtgccgctgg acagtgcccg ggtgctgggt gagtggactt caaaggctgc ctccacccgg
    13921 ggtacgaaca gccgctcgtc ctctccggcg gccttttcca aggcgtcgac catgtcgtcc
    13981 gtcagccgca gctcatcgcg gccgtccaga aggacttgct gcatcagcgc gagcagcagt
    14041 tcatcgcggt ccgtgcgcac cttcagggcg gcgccacgtt cggagccgac gtatccggcg
    14101 ggcaggccaa ggccgctgtc ggcgaccagg tccatcaccg gcaccagggc cccgacgccg
    14161 taccgggccc ggaagcggcg gtggtagtcg cgccagtgct ggtagccgta gggctgcggg
    14221 gtggtccggt agagggccga cacggctgct tgcacttccg cgatcacgga ctgcgggagc
    14281 tgggtctcgc agtcgagggc ggtgtcaatg agcagcgggg tcggggtgac ggtggtgagg
    14341 gcgcgcatcc gcgcggcgac ggcgctcacg ctggtgtcgg aaagcgtcgg ctggtgggca
    14401 gacacgtcgt cgcgcagcgc gtacagcgcg tggaccaggt cccgcacctc gcggacgtcg
    14461 tccgcctggt gccggtccag ttcgcggcac aggtgctgaa agccgtccac ggtggtcatg
    14521 ggcgcccaga ggctggtgat gaggaactgc tgctcgacca ggctggtgag aagggcgtcg
    14581 atcttctccg gtgtggcctg cgggaagcgg tcgcgcaggt ggctgtggag gtcgccgtaa
    14641 gggatggggg tgcgggccgc gtccatggcg gcggccaccg gccgggcgtt gcggacggat
    14701 atctcgaccg gggccaagag gacggcgtga ccgtcggagg gtggtcccgg cgccacgagc
    14761 cggtcaccgc gggcgcggac ggcgttgttg gcgacgagcg gtaaccgctt cagcaacgcg
    14821 ggggtgcgct ggagccggag aaccatgtca gtgacccatt cggcgtccgg ccggatcatc
    14881 gcgcggtgct tgtcgcgcca ccgcgcaatc gcccggggcc cgacggacac cggggcgatg
    14941 ccggcgaaca ggccgagcgg ggtcggccgg tgctgccacc gcaggagata ggaaaccgtc
    15001 gacagcgcgg tgcggcggac gtgacggggc tcagtctgcc ggccccggac gacggcctcg
    15061 atggcgtcgg acaggacggg ggtggccagc tccagcgcgc tgcggaagtc ctcgcgctgc
    15121 cagatgcggt tcagccatcc gcgggtgacg gccacgttgt ccaggtcgag ggtacggggg
    15181 atgtctgccg gcccggggct ggtggtggcg cgcaacatcg caacgccttg ccactggtat
    15241 ccggcggctg ctcgggaagc catgaggccc ttccatgagg cggcgcgggg aggggagagg
    15301 ggcctgnnnn nnnnnnccca caggtgaggg gtcggcctgg atcaggccgg gtcctccgtg
    15361 aaggaaccgc aggcggaggc accggtcgcg caggtggtgc cgcagccgtc gcccgtggag
    15421 cacatgagat ggccgtacga gtgctcggcg atgacgacct tcacgtccag gggcgcgaag
    15481 tcgtcgtcca ggcccgccag cggggcgggc gcgaccgggg gcggggcgag agtggcgctc
    15541 gtcatgatgt gccttcctct tgttggggtg gtgcgggacg acctggctcc cggtgttacg
    15601 ccgagggcca ggagagcgag atccggctgt gcaccttgtc gatgacccgg tcggccggga
    15661 tctggtcatc gggagtgctg gccggataga cccggatgac cgggctgggg ccgccgcgcc
    15721 ggttggcctc ccagtcgcgg agcacgccgg cgatctcgtc ggcgaactgc ttcgcgtgcg
    15781 ggccgagggc gtgcacgccg tactccaggt gcttgttgtc ctcggtgcgg cgggtgacga
    15841 ggtaggcgaa ggtgtcgtcc tcgacggccg cgagggcgaa ccgcttgttc acggggtcga
    15901 ccacgcccgt gtccgagttc tcatcgacgg ccatcgtgca gaagcccggc aggctgatcg
    15961 ccatcgccat ctggagggtg tcgatgagtt cctggatgcg gacggtgacg ccggtccaca
    16021 gttcgtggcg cgggaacgtg acggcgttgt cgagtcggtg cgggtcggcc ggcaggccgt
    16081 catcgaactt gaggccgatc tccggggtgc cgttgacgag gaggagttcc tcccggtgag
    16141 cggtcgaacc ctgcatcggg acgaagccgc agatcttcgc cgactcgctc tccaggtagg
    16201 ggccgtgctc gcccttgacc tggatgaagg cgaccgaccg ggtcaggccg cgcatccgca
    16261 gcgggacgac gagccggccg ccctccttga gctgcgcggt ccaggccggg gagacgtccc
    16321 aggccccggc agtcaccatc acgacgtcga cctcaccgag atccgggatg ggctcggcgg
    16381 cgtccgcggt gacgacgtgc acccggccgt agccgtgctt gtccaggagc cgtcgcgcgc
    16441 gatcggtgac gacggggtcg atgtccacgg tgacgacttc accgtcctca ccgacgagtt
    16501 cggcgaggta ggccgcgttc agcccgcccg agccgatctc caggacccgc atcccgggct
    16561 tcacctgggc ctgctccagc atcatggcct ggatctgcgg cgcggagacg gagctgagct
    16621 gtacgccgtg ctcgtccgtc ttggtgatca cggcggcgta tgtgtcgtac gccttgtcca
    16681 gcggcgtgtc ggcgggggtg aactcgtgcc ggagcacctt gcgcatcacc gcttcgacct
    16741 ccggggagga gatgttgccg tccgcgcaga gctcgtccac caccttgttc cgcaggcggg
    16801 tcgcctcgtc gggctcgacg gtcgtgttcg tcatggactt ccttcggtcg ttcgtgttca
    16861 ggggcgggtg ggccggcacg cgtgccgggg gccgggaggc tatcggcgaa agctctccgt
    16921 tctcgtcgga ccgccgaagg ttggcgggtt cgtgctggac ggcgcgcgaa ggtccggcgc
    16981 cggtggtgag ccgcccggcg gtcctgtctg taccactcag gagagccggg cggccgtcta
    17041 ggcggcgggc acaagatcgt ccaggttgac gaccttgtac tcccgcagtt cccgtacaag
    17101 ctgggaggcc aggaacatgc cgatctgggg atggcggtaa gggatcgggg agtccatgtc
    17161 cgagagggcc tgtaggccgt tcgcgctcca ctggtacgcg tggccgatca cgccgtacag
    17221 cgggaaacgg gtggcgagaa gcgctacgtg gccccttgcc ctgagccgtg ggcaccggct
    17281 tgccgccatc cgggcgtgct ccagacagac cggcggctgc gcggtcttca ccggaccgtc
    17341 gtagccctct tcacccgccg tttccaggaa gaggatgccg tcggtgcgct tcaactggac
    17401 ggtgcatacc tggcaccgca gcagcgccat cgtcacgcgt tgacggtgcg ggtgaaccat
    17461 ccgccaccgt ggtgtcccgc agggctgccc aaaggtgtcg agcgacatgg agtagcgggc
    17521 ccagagcacg tccttgaggt cccggtccgg cggcagctca tccacgtatc ggagacgcgg
    17581 ccggccgtcc ggcccgcggc ccatacgcag gttgaggaac gagtcggcct cttcaccttc
    17641 ccgggcggtg atgtagggca cgacggcctc gggagcggtg gtcacgcggt gctcccggcg
    17701 gcgagcgcga ccggccggtg tggagcgacg atctggccgt ccggcaacag ctcgccggtg
    17761 tcctcgaaga gcagcacccc gttgcacagc aggctccagc cctgttcagg gtgggccgcc
    17821 gtggggcggg cggcctctcg gtcggaagcc tcggccgtgg gacacggcgg ggtgtgctgg
    17881 cacatcgtac tcgtcgtcct ctcaaggcaa tgcggggaag tcgggccctc ttcggcgact
    17941 acgaagccgt gggggaacac ggagtggagg ttgccgaaga gggtgtctgt gggcgttcac
    18001 gtaggaacga ggtgatggcg gactcgctgt agccgtagaa gcggccgaag accgcgtcgt
    18061 cctcccacca ctcgggagcg ggatcgcccc actcgacggt gtggcaggtg tcgcgatacg
    18121 gcgaccatcg gacgcggagg tccggaaagc cgggttgctc aaggagcagg tcacggacct
    18181 tgaacccgaa gcagagacac gacaccgggt agtacccgcc gcgcctcgtg cccccgacgg
    18241 ggaccgcgag gaagggcatg cgcagggtgc gcacagcgat gctcttatcc aggagccaag
    18301 tgtcggagat ccgttgctcg aagtagtcga agtcgtatgc gtcttgcggg agggctatca
    18361 ccgtggtggt cacggccggg tgtcggacgg agctggtgca gtgcatcatt ccgccccctt
    18421 gatgtagcgg gcttcgatca gttcttggac caggtcggag gccacgaagg ccaggcggcg
    18481 agcgaggccg acggcccgct gttggtcggc cggggtgtgc tcctcccgca gggcgtgccc
    18541 tcgctcaacg agccggacca tctcctcggt gggcggatac ttggcgtcgg ccacggtgat
    18601 gtcgctgagc tgcttcaggt ggccgcggag acggtcgatc agggcactgg tagtcgcgac
    18661 gggcggcggc tggttgccga ttgccatgtc gaggtcgtca aagacctcct ccacgtcgaa
    18721 cggcttccag tccttaatcc gttccaggac gaacctcaag ccctctgcat cgagcggagg
    18781 agcccactgc gctgtgctgg gcgcgtcgaa tggcggagga accacgtcgt tctccggaac
    18841 cagaacggtg agggacatcg gaactcctga agagggccaa gtgccggccg taggggctag
    18901 aagtgctcgg tcgcttctgg ggtacctatg aagacccaca cgtccttgcc cgctggggtc
    18961 acggagacgg acgtgtcatc agccaaggcg cgcagcagca tcagcccgcg cccctcttcg
    19021 gccagcgagt ccggcgacgt gtacacaggc gggcaggggt cctggtcgct gacgacggcg
    19081 gtgacgccgt ccggcacctt ctggaggagc aggctggcca tccggcatcc gtcgtcgttt
    19141 gcaggggtgt gctgcaagac gttggtgagg agttcgttga ccacggtcag catgcggtgc
    19201 gcggtgccgt tgtcgatgcg ccaccagcaa aggtgcgctg cgacgatgtc ccgcacggtt
    19261 cccaggtctt cagcccggac gtcaaaactc atgtcgagtt ggccgcccac gcttctagac
    19321 atggctcgaa cagaagcgtc ccgctcgcgg gtgtcgacga gtagttccat cgctgcttgc
    19381 tccgttctgc cagaacccct tcaggcaggg gcggttgcgg tgtgtactgg actagaaccg
    19441 atcagcaacc atttatgcag agcgcaccga gcacgtgcag agcctgatgc cgagaggtga
    19501 agagttcggc atcaacgact ccggggacag aacatgccgc agccaatgaa gcagctcgat
    19561 ccgggggcgt ccccccagga gtggttcggg aacgagctgc gcagactgcg cctggagcag
    19621 ggactgtcgg ccaaggatct gggacggtta gtccaggtca gcgatgacat gatcttgtcg
    19681 atcgagaagg gcaagtaccc gagctgccgt cgcgatgtcg ttcaacggct cgatgacgtc
    19741 ctccgcacgg gagggctgct tgaccgtgcg tggccgatgg ccttcggcaa ccgcgatgcc
    19801 gatagaaagc gggctgatgc cgataacgct tccacgcgca ggggggagga acgcgtccaa
    19861 gcgccgacag gccccatcct gggcagagac gaaccgactc ttcgccctgg gagccatgag
    19921 cccgtgattc gacgctcgtt cctccaaatc ggcggcctcg ccgccatagc ccccctcgac
    19981 ctcgccgacg tcttcgcccc ctccgagctg tcgctgccga cgaccgtcaa cccgccccac
    20041 attgaccagg tcttggccgc ggccaccgcc atcagcggta tggacaacga gctaggcggc
    20101 ggtggcatgg tgcgtgacgt agccagccgc gcgatgcagt ggtcagccgg cctgctgcaa
    20161 gcccagtgcc ccgagcacct acgaaccgaa ctgttcgccg ccgtatcgcg actcggcatc
    20221 gtggtgggcg cctctgcctt cgatgcctac caccacgacg aagccaccca gactttccgg
    20281 ttcgcagcag actgcgccga ggaggctggc cactggcacc tgcgagccaa gacgtactcg
    20341 ttcctcgcac ggcaagcggt atggatcgga acccccgatg atggcctcac ctacgctgag
    20401 aaggggctcg tgcgttccga ccgtctgacc gcgacggagc aggcgatgct tcacacggca
    20461 cgggccaggg ccttcggaaa gatgggcaac gtccgcgaca ccatggcggc cgtcggtgct
    20521 gcggatgaag cgttcactcg ggcccggccc gccgaggact cgccgtggat ggcctactac
    20581 gacgaggcgc agcacaacgg ggacacagct cacgccctgt ttgatctcgc catccttgcc
    20641 ggtcaggacc cgggccgggc agctcgcaga ttcgacacag cggtgaaggg acacacggat
    20701 gcctacaagc ggtcccgggc gatctcgcgg accaaactgg cctctctgat catggttaag
    20761 ggtgaccctc gccaggccgc gacgctcggc cacgacgccc tggacgaggt aggccggctc
    20821 acctcccggc gggccgccga cgatctgcgg cagctcggcc gcttcgcctc gaagcaccgg
    20881 gcgatcccgg aggcttcggg gctgcgcgat cggatcgccg ctacggtttc ggcatgagta
    20941 attcggcagc cgctcccgcg cgccacgtct tggagcaagc ttgttccgcg gccggactgg
    21001 actccgccgg agcggaaccg ctacgcctgg ccgagaacga gatatggcgg ttacctggtc
    21061 agcgggtgat cgtgcggatt gcacgggaag gccagagtgc tgcggcggcc cgtgaggtac
    21121 gcgtcgcgcg ttggctcgcc caggaggaca tcgccgctgt tcgcctggtc gacgtggagc
    21181 agccggtcga ggcgggcggt aggcccgtga ccttctgggt ggaactcccg ccacaggagc
    21241 acggctccgt cgaagacgtc gcccaagtcc ttttgcagct gcactccttg gccacgcccg
    21301 acattgagct ggggtacctc gatcccttcg tccgggttgg cgagcgactg gaagcggcca
    21361 gcaccatccg tgacgaagac agggagtggc tgcacggcct tcaccgcgac cttgcagcgg
    21421 cctgggccga gcggccggcc ggtctccccg accgggctgt gcacggcgac gcctggcccg
    21481 gcaacatcgt ccgcacgatc gacggggccc tgatgatgga cctggagcgc ttctccgtgg
    21541 ggcctccgga gtgggatctc gtgtccaccg ccgtgcgcgc gaagaccacg ggcgccgtca
    21601 gcacacgcga gtacgaccag ttctgtgccg tctacgggca cgacgtgacg atgtgggagg
    21661 gctatcccat cctcgcgcgt gccagagagc tgcggatggt gacgtacgcg gctcagcacg
    21721 cagctaacaa cccggagtgg agcagccagg cgcaataccg gatcgactgt ctacgtggtc
    21781 gatccggccc gcggccttgg gcgtggaaag gaattctctg aacgacgcac gccccgccct
    21841 gaggacatca cacattcagg ggtaagtgat cgagttggtg taagcgtcgt agattatgtc
    21901 gccatcgctg ttgtacatgg tgaatgatgc gtatgccgtc agcccagtga agcgcgaggc
    21961 gtcggcggtc acctgttttg agggagtctc gccgcagggc ctgagactgg tggatgccac
    22021 caccttgctg gaggaccaga gggcaacgcg gtagccagcg caattcgcgg gagggtaatg
    22081 gacggttgct tgcccaatga acgtcgaact gaccaaggcc aggcatagcc tggactcgga
    22141 gtccatggcg gtgcactgct gctcattgac tgccgtccgc gcgggggacg aaacctccgc
    22201 ctgaggggag gatgcagcag ccggaatcga tcctgcccct atggtcaaac ttgcggcacc
    22261 gaatagtgcc aaaagtaaac gacgcataac tctcctcaaa tcctttcagt atcctgcttt
    22321 tgattcacga gtctgacctc cgcaagtcct gtccgcaagg ccacgacagg acaatttcag
    22381 gtcagttcat ggggttttac tcaaggcttc ggcgtagtcg tgtgatgtcc ggtttcgtga
    22441 tcatgtgagg tcgaagcagg cgaggtggcg gcgggggctg gcgggcgttc tagattgctt
    22501 ggggctcggg cacgtcgggt tcacccggcc tttctgaagc ggatacgccc ccgtacgtag
    22561 gccgcctggt ctctgctctt ccaggctgat catctttcgc gcccacttcg ggggtgacct
    22621 caccaggctc ccgagcagcg gccttcgtga acacctgctc cgcacgattc agggtcaacc
    22681 gcatcgtgcc gtaaggactc acggcgtacc cggtccggtg cccgtgcaga tgcagttcct
    22741 ccactgcctg aaggccggcg tcgccctccg gcacgtcgtc cggcgggacg agggcgtgca
    22801 gttcctccgc ccactcccaa ccgagatcac ggagcacggt ccgggcttcc tcctgctccc
    22861 agccgcttcg cgccaccagt ccgtgacgag ggtccgtcga gaagaccatg ttcgggtccg
    22921 tcatcatccg gccatctcct cgactcgtcc cgcagatgcc gtctcctcgc ccttggccgt
    22981 aggccaggcc gcgagctgga aacgcgccgg acgctcgtcg tgcttgccaa cgcggcattc
    23041 gtcgcccgcc ttgcccaacg tcttattcat tcgggtgagg aagcggtcat actgctcgtg
    23101 ccagatcacg gacgagcccg cctccgtata cgcgtcttcc cttgcgaagg ccagggctgc
    23161 gatctcgtat gcgaggctct cgtgcttcgc ccagcacggc gggatgacgt cctgcggctg
    23221 ccaggcgtac gtccggttca gccaacggca cacggagtcg agccacgcgg gcatcggcgc
    23281 gatcagctct gctgacaggg cgccgatgtc ccacggggcg ggaccgtcgg cggccacgga
    23341 ctcctctgtg ctccgctccg cgatgtactc caggatcagc gcgggcggct cggggaaggg
    23401 ctcgaagtgg gtcagggtct cggtcatgcg gcagccgctc cttcacggcc ggcccacgcc
    23461 accgcgtggg ccttggcctg gttcttcttc tcggtagccc gccgggtccg ctcggcttcg
    23521 ttggcggctc ggaggtcccg gacgtgcccc tcgatctcgg gccaggagtc ccaggtccac
    23581 atgccgtcga gccgggagac gatcggcggg aggttgtccg cgaggaccag ggcgtgcccc
    23641 tcgggaaggc ccctgatctc gtctcctcga aggacgggtt cgagcgccat gtgcgtggcc
    23701 gtcgagtgac cgccgcgatc cccgccggac gtggtcttcg tcgtgcgctc tcgctcgacc
    23761 tgaccgcaca ggtcagacat gtccttcaag aagtcggggt ccttgtcccc cggcaggacg
    23821 atgacgttgt tggtgaaggc cgccagctcc ttggcggtgt cctcgccgaa acgggcgcga
    23881 gccgacgccc acgcctggag gccgtagacc actgtgatgc ctcggccccg accgtcggcg
    23941 acgcgttggc ggagggaggg gataggtgcg atgttcggtg cctcgtccaa ggccgcgagg
    24001 agtgcggggt cgagccgccc ggccggggac gcgagggcgt gcgcctccgc gaaatccaga
    24061 aggtcttcgg ctatcgcggt ggtcagcggc gcgacgctgt tcacctcgct gtccttgccg
    24121 aggaggtaga gggtgccccc ggcgtcgagg aacgcgccga agtccgtggg gtcctctccg
    24181 tctccctgaa gggcgttgat caccgactgg tgcatgaagg gttcgagggc cgcgtcgagg
    24241 gtcgaggcgg tgttgccgac ggtgcggctg tcgcccgtgg tggccgtgcg gagcatgtcc
    24301 gcccagccgg ggccggcgcc cgggtgagcg ttgaggatgc cgaggggtgc cgggtcggtc
    24361 agcttgcggg cccaccgcag cacccagtcg agcgaggcac cgtcgagggc ggcggcgtgg
    24421 aagaaggccg cgaggatctt ggacgcctgc cccttgtaga aggcgctgcc ctcgctggac
    24481 tgtgccgcac cgttgggggt gcgcgagccc gcgacgaacg ccttcccgcg catcatcgcc
    24541 acctccgtgt cggttgcgcc gttgatcggt gtccaccgga agcgcgggag gctcggtgcg
    24601 atgttctgcg ggtcgaagac cgcgacgggg cggccgtccc gctgccgcgc gtcgagagtc
    24661 agttcgacca gatcgggctt ggtcgaggtg gccaggaccg gcccggccca gcggcggacg
    24721 agcggggcga agaagcgcag agtctttcca ctgcccatcg ggccgatgac ccggcatgcc
    24781 ttgtcggcgc gggaccacag ctcgacgccc ttcgggcgct gcgaggtgcc cagcgaatag
    24841 ccgaaatcgt gaggatcgag ggggtggtgc atgacgtact ccggagcgag gtgggcgggc
    24901 gacgaggaaa gagggtcagc gagcggcggg gcggtctttc gcgaagctca ccccggttgc
    24961 gcggctgggg tggcgatcgt cgctggtgag ggagggccgg atctcagtgg ccttcaggac
    25021 tgctttggcc gacatctggc gcttgagctg tcccttgctc gcgaatccgg cgttgcgccg
    25081 cccgcggttc accaggaacc agagcgtcac cagggctatc gcgcacacgg ccgtcacggc
    25141 gtacagggca agggagatgc cgccgggcat gatgtccatt actcggtccc ccgggcgacg
    25201 cgggccgcca ggtagcgcat ccgccggccg cacaaccgcg acatcgacgc gtcgggcccg
    25261 gca
//
