LOCUS       NZ_CP051627            23886 bp    DNA     circular CON 21-APR-2024
DEFINITION  Thermobifida alba strain DSM 43795 chromosome, complete genome.
ACCESSION   NZ_CP051627
VERSION     NZ_CP051627.1
KEYWORDS    RefSeq.
SOURCE      Thermobifida alba
  ORGANISM  Thermobifida alba
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsaceae; Thermobifida.
REFERENCE   1  (bases 1 to 4903256)
  AUTHORS   Luzics,S., Horvath,B., Nagy,I., Toth,A., Nagy,I. and Kukolya,J.
  TITLE     Thermobifida alba genome sequencing and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4903256)
  AUTHORS   Luzics,S., Horvath,B., Nagy,I., Toth,A., Nagy,I. and Kukolya,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2020) NGS Platform, Seqomics Ltd., Vallakozok u.
            7., Morahalom 6782, Hungary
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: RA v. v0.2.1; CLC Genomics Workbench v. 11.0.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 331.0x
            Sequencing Technology             :: PacBio Sequel; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023208015.1-RS_2024_04_21
            Annotation Date                   :: 04/21/2024 13:45:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,356
            CDSs (total)                      :: 4,290
            Genes (coding)                    :: 4,246
            CDSs (with protein)               :: 4,246
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 44
            CDSs (without protein)            :: 44
            Pseudo Genes (ambiguous residues) :: 0 of 44
            Pseudo Genes (frameshifted)       :: 10 of 44
            Pseudo Genes (incomplete)         :: 35 of 44
            Pseudo Genes (internal stop)      :: 3 of 44
            Pseudo Genes (multiple problems)  :: 4 of 44
            CRISPR Arrays                     :: 12
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:37:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3932587
            Orig. end                         :: 3956473
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP051627.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23886
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="12"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..23886
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23886
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13886](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13886
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(1455..1469)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.52"
                     /tool="antismash"
     gene            2624..3412
                     /locus_tag="FOF52_RS17485"
                     /old_locus_tag="FOF52_17370"
     CDS             2624..3412
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018738.4"
                     /locus_tag="FOF52_RS17485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_17370"
                     /product="sporulation protein"
                     /protein_id="WP_248591001.1"
                     /transl_table=11
                     /translation="MVLKRLMRVFGVGGPTVETVFDSTEVAPGGTLTGRVEVTGGDHDT
                     EIEKITLTLEAEVEHEYEYTTEDSEGEEVEHEGEYTATRSWGRLLVCEAFSLPAGEHRV
                     FGFELPVPFEAPLTVSGGTPLNGPKVGVRTRLHVDRAFDKRDLDPLAVHALPVQERILT
                     ALDELGFQLVESDLEPGELIGTDQTLPFHQEIEFGASPRYEAVGDLEVSFVTDEEGAHV
                     VFQLDGLDDRGHTFRVSHAEAETTDWAERLASELEAAMNR"
     misc_feature    2673..2688
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.17"
                     /tool="antismash"
     gene            complement(3425..5515)
                     /locus_tag="FOF52_RS17490"
                     /old_locus_tag="FOF52_17375"
     CDS             complement(3425..5515)
                     /EC_number="2.7.7.7"
                     /GO_component="GO:0009360 - DNA polymerase III complex
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011290498.1"
                     /locus_tag="FOF52_RS17490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_17375"
                     /product="DNA polymerase III subunit gamma and tau"
                     /protein_id="WP_248591002.1"
                     /transl_table=11
                     /translation="MSIALYRKYRPATFAEVRGQEHVTEPLRQALRNGRVNHAYLFSGP
                     RGCGKTSSARILARSLNCVQGPTPDPCGECESCVALAPDGGGSIDVIEIDAASHGGVDD
                     ARDLRERAFFAPVNSRYKVYIIDEAHMVTREGFNALLKLVEEPPPHLKFVFATTEPEKV
                     IGTIRSRTHHYPFRLIPPSTLRELMEEILTEEGVPYDPAALPLVVRAGGGSARDSLSIL
                     DQLLAGSDERGITREGAVQLLGYTDSSLLGEMVDALGARDGAAVFGLIDRVVEGGHDPR
                     RFAADLLERVRDLVVLNAVPDALDKGLINVPPDAVEQMREQAGRLGAAQLTRAAEILNK
                     GLTEMRGTTAPRLLLELMCSRILLPAVDPGDELALAARLERLERGGAAAAPAAAAVAPA
                     PAGGAPSAAPPPAPAAPDRPVAPPPEARPQQPPAAPSRPQPRPAPADDWGSPAQPGTPA
                     PAAQQRPQVPAGGGSFDDRWPHILEYLASNRKRAAHAIVRDGVRTTVLNGRTLTLFFET
                     DGLMRSFVTGGRARDIAEAVQRVCGLEVSVEASTGNPGSAAPRAPQAAAPRPPQPVREP
                     AAPPAPQPDRDAPPAPPSAPSPGSASRGAAETGWDDVPVAFSRPEPAGVQPAPEPPAPP
                     EPAPRPQPGPAEAADSGPAGDSSLAPEDAAENDLDESAFTGSLLIESELGGHLIEEIDH
                     TK"
     ncRNA           complement(5647..5742)
                     /db_xref="RFAM:RF00169"
                     /gene="ffs"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00169"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /locus_tag="FOF52_RS17495"
                     /ncRNA_class="SRP_RNA"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /old_locus_tag="FOF52_17380"
                     /product="signal recognition particle sRNA small type"
     gene            complement(5647..5742)
                     /gene="ffs"
                     /locus_tag="FOF52_RS17495"
                     /old_locus_tag="FOF52_17380"
     misc_feature    complement(5796..5810)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.57"
                     /tool="antismash"
     tRNA            5869..5953
                     /anticodon=(pos:3938490..3938492,aa:Ser,seq:gga)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FOF52_RS17500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="FOF52_17385"
                     /product="tRNA-Ser"
     gene            5869..5953
                     /locus_tag="FOF52_RS17500"
                     /old_locus_tag="FOF52_17385"
     gene            <6064..6345
                     /locus_tag="FOF52_RS17505"
                     /old_locus_tag="FOF52_17390"
                     /pseudo=""
     CDS             <6064..6345
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018933.4"
                     /locus_tag="FOF52_RS17505"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_17390"
                     /product="zinc ribbon domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="ADREFVCAECGLQLDRDLNAARNIAAHAEIVPPGTGAPGRGEPLN
                     ARGDRVSPVLLKGERATVIEAGRRWPLRASATSAEQSADVPLARISKR"
     misc_feature    6097..6099
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6193..6195
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     repeat_region   6375..7011
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=3938962..3938990
                     /rpt_unit_seq="gtgcgggccttacgcgcgcgggacgaccg"
     gene            complement(7399..7776)
                     /locus_tag="FOF52_RS17510"
                     /old_locus_tag="FOF52_17400"
     CDS             complement(7399..7776)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019633212.1"
                     /locus_tag="FOF52_RS17510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_17400"
                     /product="hypothetical protein"
                     /protein_id="WP_248591003.1"
                     /transl_table=11
                     /translation="MHDERGRLFRDAWIAGVKNHYPGDPKPGYIAPWEDTPDWERAAAA
                     AVYDQVAAFVETTNGATAKLTRSQKGRFVALCWIGQIYKHFPDPKPSYVADWDDLPAWQ
                     QETDADIFEQIEIHVRADKAV"
     gene            complement(7794..9353)
                     /locus_tag="FOF52_RS17515"
     CDS             complement(7794..9353)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FOF52_RS17515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_248591004.1"
                     /transl_table=11
                     /translation="MASVICGHCGHDRAEGRCECIPVAFWQRADVREAVARSDVTRIVR
                     LLRTHTELTQEAIGNMTGLSQGMVSQMESGKRSLRDAAKKRRALEGLGILPPASTMRAG
                     PSGAGAPLDTSDTEDISARTCTTPAVEGFHSNGPVGQPLPQRPLSRKASPDPQNDRSLL
                     PVWPGQTGAPENDDMNRRELLRLFSVTGTLLALPSAGFVPGIDQAISSIPGRSGHLDAT
                     ALDEYTQLNSNLWRVFGLTPSKSQVLPLVRTQLDVLTDKLKQPHGEAARQRLCLLTADL
                     FQLAGEIFFDGNHYTDAAHCYSLSASAAKEAGAFDLWACALTRHAFVAVYERQFPQAVP
                     LLELATALAHRGDSTLSTRYWVAAVQAETFAGLGDQDACQRALDTAEQVLDLPGQVHNG
                     GWLRFDGSRLAEERGTCYVALGRSDLAETALTKALTGPLTVRRRAGVLTDLALLGVQRR
                     DPEQVVAFTAEAVEAARQTGSGVINRKLRGLQQYLLPLLRDRRIRRLNDDITALTRPAV
                     SG"
     misc_feature    complement(9599..9615)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.16"
                     /tool="antismash"
     gene            9749..9919
                     /locus_tag="FOF52_RS17520"
                     /old_locus_tag="FOF52_17410"
     CDS             9749..9919
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="FOF52_RS17520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_17410"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_248591005.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.4e-08, bitscore:
                     32.5, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNTVAAEPSVSEDPFALDVQIVTDIPPGDPLFACGEGTNDGCQP
                     TCASACVTGGV"
     gene            10001..>12000
                     /locus_tag="FOF52_RS17525"
                     /old_locus_tag="FOF52_17415"
                     /pseudo=""
     CDS             10001..>12000
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="FOF52_RS17525"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="FOF52_17415"
                     /product="lantibiotic dehydratase family protein"
                     /pseudo=""
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.3e-76, bitscore:
                     254.1, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.2e-12,
                     bitscore: 45.5, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGATTKLARLYRHTGAALLRAAAVPLSTSSLSWPDLTDPTASRAW
                     LARVWDDPRLAEAVGQASPSLEKTVAVLRTGNPVRDKQVRSASLSTVRYLLRSIGRPTP
                     FGLFAGVAPVKLGPTAKVAWGHNHRAAARVNTEWLIDIIEQAESCPELLDRLFVVLSDL
                     AHRRGRRLEVPRGPNRVTLNYTRVVAVLCDRATTPIRFAALVDMLAEEFAVDRDRVRST
                     LTELVKNGCLITNLRAPFTVTDPLAHVVDQLREAGADTVAHTAPLLRALEEIQNELQHH
                     NHPATTPQDQKHSRALVTSAMRELSRAGRMPLALDLLLDCQVRLPRQVAHEMERAASAL
                     LRLTRQPTGEKPGTTTMRRSSSATAQEPSYHSPMSSTPTPDSATRLDTAAACSPYQETD
                     PRHEMNDCCPWLGRLWLQTAVRSSLPTQTLTL"
     misc_feature    10283..10285
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    10454..10456
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        10472..10717
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FOF52_RS17525_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.40E-14"
                     /identifier="RREFam001.1"
                     /label="FOF52_RS17525"
                     /locus_tag="FOF52_RS17525"
                     /protein_end="239"
                     /protein_start="157"
                     /score="45.5"
                     /tool="antismash"
                     /translation="VVLSDLAHRRGRRLEVPRGPNRVTLNYTRVVAVLCDRATTPIRFA
                     ALVDMLAEEFAVDRDRVRSTLTELVKNGCLITNLRAP"
     misc_feature    10799..10801
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    11270..11272
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    11699..11701
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12217..13047
                     /locus_tag="FOF52_RS17530"
     CDS             12217..13047
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="FOF52_RS17530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_282574080.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.6e-25, bitscore:
                     88.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNTHGQLSGAAEAIWLSTKLFTHPERMTEIVTEQLPALLAELNS
                     PPCWWLRYRSSRETDHLRIRIRTSPDRYGRQVRKVAEWAQQLRRTGVAGALSFDTYSPE
                     IGRYGAGPALNAAEEVFVADAELVAALLRQQATSPVDPTASVVANMVAIVTGFYGDPTA
                     AMNWLAQRPTPTAPAIDRRVADEAIRISTETSARSLWGRSHELDALWQRRADALKAYRM
                     ALPADANINIVVESLLHMHHNRAVGIGPEHERTCRRLARQASLSWLARKGNGVR"
     gene            13044..13886
                     /locus_tag="FOF52_RS17535"
                     /old_locus_tag="FOF52_17420"
     CDS             13044..13886
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="FOF52_RS17535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_17420"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_282573654.1"
                     /sec_met_domain="LANC_like (E-value: 1.6e-18, bitscore:
                     64.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNVLRHVPQSGLAPAQRQSLAFGALGTALLHIVRACTGAEEWDT
                     AHQWVTTVTRGPVAAHTEANLFYGAPAVAFVLRIAAKRSHTTVLAALDDHITALTRARL
                     DQAYARISRGELPRLGEYDLISGLTGIGVYLFQAQNADLLREVLAYLVRLTATVTIGDR
                     RLPGWWTLHGPSDRPDPRWPGGHANLGLAHGISGPLALLAQTMLHGITVPARQKPSLTS
                     TGYWIVGFVTFPIAPGGQGPSPLGNGKAKPFTKPARNDRPGATELLVWPALGSSLLSP"
     gene            14269..15480
                     /gene="fxlM"
                     /locus_tag="FOF52_RS17540"
                     /old_locus_tag="FOF52_17425"
     CDS             14269..15480
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="FOF52_RS17540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_17425"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_248591007.1"
                     /sec_met_domain="PCMT (E-value: 2.5e-52, bitscore: 175.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNAAGTRPEQLRDRMVDRIRTAGHLRSPRVEHALRTVPRHRFVP
                     EASTEDAYADKAITIKPGTDRPASCISVPTVVAMMLDQLDPQPGERILEIGAGTGYNAA
                     LLAELVGPEGRVTTVDIHSDVVDHARRTLAETGYSRVRVVNADGVLGYPQDAPYDRIIV
                     TVGPWDLPRAWFDQLRDGGRLVVPLHWRGQSRSIAFTRYADKLRATDSRLCGFIPMVGN
                     SDGERTAEITDHVALYWDAGQDISPTALHSVFTRSESTVWSGVTVAANEPFDHVWLWLS
                     ATEPGTCRLAAEPAAIDAGVCHAVFPYRTPAIVEGDSLAYLTRPRPVDQDDEPRFELGA
                     TGHGPAGTDLAERLCASIRLWDRDRDAQPVITVWPTAVGHADPQHHEGVVIDKEHVRLV
                     LTHR"
     gene            15615..16856
                     /gene="fxlM"
                     /locus_tag="FOF52_RS17545"
                     /old_locus_tag="FOF52_17430"
     CDS             15615..16856
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="FOF52_RS17545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_17430"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_248591008.1"
                     /sec_met_domain="PCMT (E-value: 1.4e-45, bitscore: 153.6,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRGSAEAARAEELRSVLVDRLCGDGVVRSAAVEAALRRVPRHLF
                     VPGTSLEEAYADEAVYTKRDPDTGASISAASQLRIVAMMLEQLQAAPGMRVLELGAGTG
                     YNAALLAALVGPEGRVTTVDVDDDLVAGARDHLAAAGAPNVEAVLGDGALGHPDSAPYD
                     RIIATVGAYEVPTAWLEQLAPGGRLVVPLRLSGAVSRSIVFERAERGWTSRGSELAVFM
                     PLRGIGDDARRVIDLTGDGQVTLQTHGDNTDADADGLAGVLGAGRCEAWSGVCFVPRES
                     FEWLYLWLSCRLANPLMRMNVEPAARDSGLVAPMFPTTAMATTRGGDLAYLTIRAAEPG
                     PDSARRYEVGVIGHGPGAEELAYQVVEEVRVWDRDHRNHQARFELPDTAVVSDPEAGRY
                     VLDRPRHPVTVIWE"
     gene            16853..17512
                     /locus_tag="FOF52_RS17550"
                     /old_locus_tag="FOF52_17435"
     CDS             16853..17512
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FOF52_RS17550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FOF52_17435"
                     /product="hypothetical protein"
                     /protein_id="WP_248591009.1"
                     /transl_table=11
                     /translation="MITDTVALARRFPLVARSRPPCAPLDARVGELCRLADSAARSTDP
                     TAASAVYNQAALLASDAGLLELARTWCHRHAILLFCGKRVADRDVHTMLGLYQALECPG
                     RTAVFHTRLGLTVVDALGGTDHPRGGRIATDLIRRAIEERDGYRAREILTHPSGAAQPV
                     RDELAEVTASCGLGTGRLPEALHALLTEAVATSEATLTRTLRMGIGQARGGPRSRR"
     gene            complement(17601..18452)
                     /locus_tag="FOF52_RS17555"
                     /old_locus_tag="FOF52_17440"
     CDS             complement(17601..18452)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013775.4"
                     /locus_tag="FOF52_RS17555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_17440"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_248591010.1"
                     /sec_met_domain="APH (E-value: 4.5e-18, bitscore: 64.0,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAALCDRVGLDPTGAQLIKFTNNAALRLATAPVVVRIAGSRAARA
                     SITTVVQVARWLTGQDMPAVRLLSGIDQPVEAAGHVATFWEEVPVTGPAPTGADLGRIL
                     RRFHALPEPDFALPDWAPFPRIRARIADAQGISARDQEWLLEQCAAVEAEVRSLDYVLE
                     AGLIHGDPFLGNLIPGPDGPVLCDFDGVSWGPREWDLTPVAVGRLRMNYPEDHHTPLAD
                     AYGYDVTAWVGFPVFRRLRELVLVTSVLPQLAGNPGIRAQWEPRYASFRAGDTRTRWDT
                     YH"
     gene            complement(18518..19888)
                     /locus_tag="FOF52_RS17560"
                     /old_locus_tag="FOF52_17445"
     CDS             complement(18518..19888)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.4"
                     /locus_tag="FOF52_RS17560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_17445"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_248591011.1"
                     /transl_table=11
                     /translation="MASVICGHCGHDRAEGRCECIPVAFWQRADVREAVARSDVTRIVR
                     LLRARTDLTQEAIANMTGLSQGMVSQMESGKRSLRSPIKKRRALEGLGTPQPVLEYVTH
                     FSGPEVCSETTEVHDLIAYAAQVTMGVVPQTPDRWTSPFTIEAAQVPQRVTMANVEHLE
                     AVTHSLRAADYRYGGGACRDAINAHTAHARRFLTAASENDRVKARLHLALADLHNLAGW
                     TEFDIGGHSTARWHFARALEHAHHAQEPSLSANVLYRMGRLHLHRGLISDALRFFQLGQ
                     IAGQNSGCGVTVAILHANEAWAYALTGDPSRALQALGRSQDEFTRTDHTRVPSWARFFG
                     TADLDAMTGVVNASLVELVPRAYNQATTSLTRSLSQRGPEMSRSRAFELAALATAHITG
                     GDTAEGVEAGYAAVDLAERLCSARVIDRLAPLAAAAQAVHTIDAADLVERIATLRTR"
     misc_feature    complement(19052..19054)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            20013..20159
                     /locus_tag="FOF52_RS17565"
     CDS             20013..20159
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FOF52_RS17565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_248591012.1"
                     /transl_table=11
                     /translation="MDEDRNELGRPHACWVRGAGENPRIDEEIHRRITDLADPSRPRHW
                     HPY"
     gene            complement(20153..20641)
                     /locus_tag="FOF52_RS17570"
                     /old_locus_tag="FOF52_17455"
     CDS             complement(20153..20641)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FOF52_RS17570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FOF52_17455"
                     /product="hypothetical protein"
                     /protein_id="WP_248591013.1"
                     /transl_table=11
                     /translation="MEARATAAAGDAAACTRAMAAAETEFVRSRPEEDPEWIGYFDACE
                     FTDELAHCHRDLGRAAAARTHAEECLRLSTGDDYARSRSFSHMVRVAAVLAQNELDEAA
                     ALGTAVLPLVERTASARVRGYLDSLVRRFTAHSAHPAVREFLDRSVPVVGRLPIRRGQ"
     gene            21191..21757
                     /locus_tag="FOF52_RS17575"
                     /old_locus_tag="FOF52_17460"
     CDS             21191..21757
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FOF52_RS17575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FOF52_17460"
                     /product="hypothetical protein"
                     /protein_id="WP_248591014.1"
                     /transl_table=11
                     /translation="MRNPDLWDALATAIIRQVIRAGQARLMYQRFSAAFGESVTRDGNR
                     LRAFPAPETVLAVSDAEYARLGMAFKRRPLRAAAEAFLDLGDKWASLPPTDLVTEVQSV
                     HRIGPWTAGAAVADHTGDFSRYPCGDLAVRTYAAQAAPGLAWPDSEPEFAARWKRCTTT
                     PRELSTLTVLTLALGGRRAQEYAPD"
     gene            21732..23195
                     /locus_tag="FOF52_RS17580"
                     /old_locus_tag="FOF52_17465"
     CDS             21732..23195
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017627792.1"
                     /locus_tag="FOF52_RS17580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_17465"
                     /product="radical SAM protein"
                     /protein_id="WP_248591015.1"
                     /sec_met_domain="PF04055 (E-value: 8.2e-17, bitscore: 60.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHRSTPPTDPIRGHNPDHALDALFVNTPLRDYAQRPRVNDFTLPV
                     LGVGYIATYAAHRGFNVGVLDAEALGLSVADTVAAVNRARPRWVGFNLLAPTYEISATI
                     ASGLDPDIKVMVGGHQAKAMPTQILTDERMARCAALVIGEAETRVAELLDDHHRRADLP
                     GVMWLDPLLKTPVTGGRPGHGHHLAPPVDGLPFVDRRYLVQDPYSDAGRWEAAIVAARG
                     CPYDCSFCGAAVSANPDVTIRVRSAEGIVAEMEQLRDNLGVTAFRFVDDLFLGARRVID
                     QMTVCFTKARIGDWAVWDATGRINVLHRLDEATLDLLAANGLREVALGIESGSERVLTY
                     IDKRITRDMVRSVIVRLLSRGINVKGYFILGFPTETREEMAETVALVHELWDLADRAPG
                     RFRSSVFEFRPYPGTPEWRRLLATGRYTPTQLLNYTAVDLTDQGVDVALHHRDEFNFST
                     GIQFGEPTVEEVRAALVELSRSEYMRRAA"
     gene            23192..23806
                     /gene="tmk"
                     /locus_tag="FOF52_RS17585"
                     /old_locus_tag="FOF52_17470"
     CDS             23192..23806
                     /EC_number="2.7.4.9"
                     /GO_function="GO:0004798 - thymidylate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0015949 - nucleobase-containing small
                     molecule interconversion [Evidence IEA]"
                     /codon_start=1
                     /gene="tmk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017627791.1"
                     /locus_tag="FOF52_RS17585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_17470"
                     /product="dTMP kinase"
                     /protein_id="WP_083947944.1"
                     /transl_table=11
                     /translation="MSGLFVAFDGPGGAGKSTTVRLLRERLSEEGLPVVATTEPSHSAL
                     GRFTRAHTGDYRGLSLACLVAADRYHHLDTEIRPALAAEQLVLCDRYLASSLVLQAGID
                     GVPPEFVRALNTHVDLPDLNVIMTAPPDVLRERLTTRGSHGRFEDDPANTDREFVLYQE
                     VLAMLEGIGVPTLVIDTGSDVGTTVSRLAATIQALWSHRHL"
ORIGIN
        1 agtgcgactt gttgaaggcg tagccggaga acgggagcat gacgtcccac agcgtctgga
       61 tggcctccgc ggagaagccg cgctccagca tgcccgaacg gaacgtctcg tactccttct
      121 ccaggacctc cttcttcttc ttgcccatcg cgcggcgcat caggtccgcg ccgcccagcg
      181 tgtacccggc gagctgctgg gcgatcgcca tgatctgctc ctggtagacg agcaggtggt
      241 aggtctcgga gaggatcggg tccagagcct ccttcagctc cgggtggatc ggggtgacct
      301 cctggcgtcc gttggagcgg tcggcgtagt cgttgtgcgc gttggcggcc atcggaccgg
      361 gccggtacag cgcgctgacc gcggagatgt cgctgaagta cttgggctgc atgcgcttga
      421 gcagcgcgcg catgggaccg ccgtcgaact ggaagacgcc gagggtgtcg ccgcgggaca
      481 gcagttcgta ggtcttcttg tcgtccagcg gcaggttcgc caggtcgagt tccttgccct
      541 cgttggcctt cacgctctgc accgcgtcgt cgatgatcgt caggttgcgc aggcccagga
      601 agtccatctt cagcaggccc atctcctcgc actgggggta cgggaagccc gtgatgatgg
      661 cgccgtcggt gtcgcgcttg tgcagcggga tgacgtcgag cagcggctcg gaggagagga
      721 tgacgcccgc ggcgtgcaca ccggtgcccc gggtcaggcc ctccagaccg ctggcggtct
      781 cgtagacctt gcggacgtcc gggtcggact cgatgagctg gcgcagctcg accgcctcgt
      841 ggtagcgggg gtgcgactcg tcgaagaccg cggagagcgg gatctccttg cccatgacgg
      901 cgggcgggaa cgccttggtg atcttgtcgc cgagcgcgta ggggtagccg aggatgcggg
      961 tggcgtcctt gatggccgcc ttggccttga tggtgccgaa ggtgaggatc tgcgcgaccc
     1021 gctcctcgcc gtagcgttcg gtgacgtagc ggatcatgtc gccgcgctta cgctcgtcga
     1081 agtccaggtc gatgtcgggc atcgacacgc gttcggggtt gaggaaccgc tcgaacagca
     1141 ggccgtaggg catcgggttg aggtcggtga tgccgaggat gtaggcgatc atcgacccgg
     1201 cggcggagcc ccgccccggg cccagcgcga tcccggagcg gcgcgcgtac tggcagatgt
     1261 cggcgacgac gaggaagtag gcggggaacc ccatcttctc gatgacgttc agctcgtact
     1321 cgatgcgttc acgcgtctcc cggtcgggcc cgtcggggaa ccggctgggg atgcagcgct
     1381 ccacctcctt gcgcagccag ctcgcctggg tctcgccctc cggcaccggg aacttgggca
     1441 tcaggtcgcg gggctggaac acctcgtcgt aggcgccgtc ctcgacctgc tcggcgatcc
     1501 acagggtgtt gcggcagccc tcggcccact catcgaagtg gttgaggtcg cgcatctcgt
     1561 cggcgctctt gaggtagtag ccggtgccgt tgaaccggaa gcgggtgggg tcgtcgaggt
     1621 tcttgccgac gcccacggcc agcagcgcgt cgtgcgcggc ggcctggtcc tcggtgacgt
     1681 agtgggagtc gttggtgacc agggggcgca ggcccagttt cctgccgacg gacagcaggc
     1741 cggagcggac ctcgcgttcg atgtcgatgc cgtggtccat cagctccagg aacaccgagt
     1801 cgcggccgaa gatgtcctgg agcttgcccg cgtactcgat ggcctcgcgt tcctggccga
     1861 gccgcagccg ggtctgcacg ccgccggagg ggcatccggt ggtgaccatg atgccctcgc
     1921 tgtactgggc catcaggtcc aggtccatgc gcggtttggt gtagtagccc tcgatggagg
     1981 ccagggacga cagccggaag aggttgcgca gccccttggc gttcttcgcc cacatggtca
     2041 tgtgcaggta gcggccgccg ccggagacgt ccttgccgcc ctcggccgcg tcgtcgccgg
     2101 tcttgccctg cccccagaac acccgctgct tgtggaagcg ggactcgggc gccacgtacg
     2161 cctcgatccc gatgatcggc ttgaccccgg tgcccttgga ggtctgccag aactcgtagg
     2221 agccgaacat gttgccgtgg tcggtcatcg ccacggcggg catgcccagc cgggccgcct
     2281 cggcgaacag cggcttgagc ttggcagccc cgtccagcat cgagtactcg gtgtggacgt
     2341 gcaggtggac gaagggatcg ttcgtcacgg tgcgactact cccaacgcga cttggagaag
     2401 agacgggtgt ggctcatgag cctacgactc tcccatgccc cgtgggacgc catccacagg
     2461 tgcggaacgc gacggacacg gcttttcccc aggacgccgt ccaccggggc ccgtggtgcc
     2521 ggaacgtccg accctgcggc cggaaccggc agaaccccaa caaaccaccg gggattctgc
     2581 gaatctggta cgcgtccacc ccaccacccc cggaaggatg ccgatggtcc tcaagcgcct
     2641 catgcgcgtc ttcggcgtcg gcggccccac cgtcgagacc gtgttcgact ccaccgaggt
     2701 ggcccccggc gggaccctca ccggacgggt cgaggtcacc ggcggggacc acgacaccga
     2761 gatcgagaag atcaccctca ccctggaggc ggaggtcgag cacgagtacg agtacacgac
     2821 cgaggactcc gagggcgagg aggtggagca cgagggcgag tacaccgcca cccgctcctg
     2881 gggccgcctc ctggtctgcg aggccttctc cctgcccgcc ggggagcacc gggtcttcgg
     2941 gttcgagctg cccgtcccgt tcgaggcgcc cctcaccgtc tccggcggga ccccgctgaa
     3001 cgggccgaag gtcggcgtgc gcacccggct gcacgtcgac cgggcgttcg acaagaggga
     3061 cctggacccg ctcgccgtgc acgcgctgcc ggtgcaggaa cggatcctca ccgccctcga
     3121 cgagttgggg ttccagctcg tcgaatccga cctggagccc ggagaactca tcggcaccga
     3181 ccagacgctc cccttccacc aggagatcga gttcggggcc agcccccgct acgaggccgt
     3241 cggagacctg gaggtctcct tcgtcacgga cgaggagggc gcccacgtcg tcttccaact
     3301 cgacggcctg gacgaccgcg gccacacctt ccgggtctcc cacgccgagg ccgagaccac
     3361 cgactgggcc gagcggctcg cctccgaact ggaggccgcg atgaaccgct gaccgcgggg
     3421 cggactactt ggtgtggtcg atctcctcga tgaggtggcc gcccagttcg ctctcgatga
     3481 gcagggaacc ggtgaaggcg ctctcgtcca ggtcgttctc cgccgcgtcc tcgggggcga
     3541 gcgaggaatc gccggccggt ccggagtcgg ccgcctcggc cggtcccggc tggggccggg
     3601 gggccggctc gggaggcgcg ggcggctccg gggcgggctg gacgcccgcc ggttcggggc
     3661 gggagaaggc caccgggacg tcgtcccacc cggtctccgc cgccccccgg gacgcggatc
     3721 ccggcgaggg cgcggaaggc ggcgctggag gggcgtcccg gtccggctgg ggtgcgggcg
     3781 gtgcggcggg ttcccggacc ggctgcggcg gacggggcgc ggcggcctgc ggggcgcgcg
     3841 gcgccgcact gcccgggttc cccgtggacg cctccacgga gacctccaga ccgcacaccc
     3901 gctgcaccgc ctcggcgatg tcccgggccc gcccgcccgt gacgaagctg cgcatcaggc
     3961 cgtcggtctc gaagaagagg gtgagggtgc gcccgttcag cacggtggtg cgcaccccgt
     4021 cgcggacgat ggcgtgcgcg gcccgcttcc ggttgctcgc caggtattcc aggatgtgcg
     4081 gccaccggtc gtcgaacgac ccgcccccgg ccgggacctg gggacgctgc tgcgcggcgg
     4141 gcgcgggcgt gcccggctgt gcgggggagc cccagtcgtc ggccggggcc ggacgcggct
     4201 ggggccggga cggggccgcg ggcggctgct gcggccgtgc ctcgggcggc ggcgcgaccg
     4261 gacggtccgg tgcggccggg gcgggcggcg gggccgcgga cggcgcgcct cccgccgggg
     4321 cgggcgcgac cgcagcggcc gcgggggccg ccgcggcacc gccgcgctcc aagcgctcca
     4381 gccgggccgc cagcgccagt tcgtcaccgg ggtcgacggc gggcagcagg atgcgcgagc
     4441 acatcagttc cagcagcagc cggggcgcgg tggtgccgcg catctcggtc agccccttgt
     4501 tgaggatctc ggcggcgcgg gtcagctgtg ccgcaccgag ccggcccgcc tgctcgcgca
     4561 tctgctccac cgcgtcgggc ggcacgttga tcagaccctt gtccaacgcg tcgggcaccg
     4621 cgttgagcac caccaggtcg cggacgcgct ccaacaggtc ggcggcgaac cggcgggggt
     4681 cgtggccgcc ctcgaccacc cggtcgatca ggccgaacac ggcggccccg tcgcgcgcgc
     4741 cgagcgcgtc gaccatctcc ccgaggaggc tggagtcggt gtagccgagc agctgcaccg
     4801 cgccctcgcg ggtgatgccg cgctcgtcgg agcccgcgag cagctggtcg aggatggaca
     4861 gcgagtcacg cgcggagccg ccgccggcgc gcaccaccag cggcagcgcc gccgggtcgt
     4921 agggcacgcc ctcctcggtg aggatctcct ccatgagttc gcgcagcgtg ctcggcggga
     4981 tcagccggaa cgggtagtgg tgggtgcgcg accggatcgt gccgatgacc ttctcgggct
     5041 cggtcgtggc gaagacgaac ttcaggtgcg gcggcggctc ctcgacgagt ttcagcagcg
     5101 cgttgaaacc ctcgcgggtc accatgtgcg cctcgtcgat gatgtagacc ttgtaccgcg
     5161 agttcaccgg cgcgaagaac gcgcgttctc gcaggtcacg cgcgtcgtcg acaccaccgt
     5221 gggaggcggc gtcgatctcg atgacgtcga tgctgccgcc gccgtcgggg gccagcgcca
     5281 cgcacgactc gcactccccg cacgggtcgg gggtggggcc ctgcacgcag ttgagcgagc
     5341 gggccaggat gcgcgcgctg gacgtcttgc cgcagccgcg cggaccgctg aacaggtagg
     5401 cgtggttgac ccgcccgttg cgcagcgcct ggcgcagcgg ctcggtgacg tgttcctggc
     5461 cgcgcacctc ggcgaaggtc gcgggacggt acttgcggta cagggcgatg ctcacggcgc
     5521 gctcactgct ccctccgcgg accggcgctg tggggtcaca ggctcctcgg tggcgtccac
     5581 gccatccatt caaccccgtt ccgatgacag tcaggggctg ctccgcgcga tcggcggccc
     5641 caaacgcgaa aggacccccc gcgcacccgc cagagcctac ttatccttgc tgccttccgg
     5701 ccctggggag gttcgtagga tgacgccgca cgaggggtct gtccgagagt ctataggccc
     5761 ccgacgggtt tcgcgaaccc ggacgttccg cagctcggac cggtacttcc ccggccggga
     5821 cggggaaccg gttcggagca ctgtccgatt ccatgtagag tgttctgcgg aggattcgcc
     5881 tagtggccta gggcgcacgc ttggaaagcg tgttgggggc aacccctcaa gggttcgaat
     5941 cccttatcct ccgcaccgcc tgaccaggca gcacgaggcc ccggagcgcc cagcgccccg
     6001 gggcctcgtc gtgcttccgt ctcagtttca gcatgcggac ggcgaaaccc aagccaaacg
     6061 ctcgccgatc gggagttcgt gtgtgccgag tgcggattac agctcgaccg tgatctcaac
     6121 gcggcacgca acatcgctgc ccatgcggaa attgtgccgc ctggcacggg cgcccctggt
     6181 agaggggagc ccttaaacgc ccgtggagac cgtgtcagtc ctgtcctcct caagggagag
     6241 cgggcaacag tcatcgaagc gggaagacgc tggcctctgc gggccagcgc cacctcggcg
     6301 gagcaatccg ccgacgtccc tctcgcgcgt atctcaaaac ggtaaagctt ctgcttagat
     6361 gcaggtcagt aactgtgcgg gccttacgcg cgcgggacga ccgtacaccg cgacccggcg
     6421 cgggtccgtg gcccgcgtgc gggccttacg cgcgcgggac gaccggtctt ggcggacgcg
     6481 ctgcgggccg gggtcgtgtg cgggccttac gcgcgcggga cgaccgccgc caggacagcc
     6541 cccacgcccc gccaccccgt gcgggcctta cgcgcgcggg acgaccggag gcccctcatg
     6601 accagtccgt tctggctgag tgcgggcctt acgcgcgcgg gacgaccgca ccccgccccg
     6661 tgggggggtg cgcatcagtg cgggccttac gcgcgcggga cgaccgtccc gggggctcat
     6721 cgcgcccgag gaggcagcgt gcgggcctta cgcgcgcggg acgaccggct gaggccgacc
     6781 gcgccacccg gcaggcggag tgcgggcctt acgcgcgcgg gacgaccgcc gtgtggccag
     6841 ggggcgccgc ctgcggtggc gtgcgggcct tacgcgcgcg ggacgaccgc ccacgacgag
     6901 gaagaggtgt acgcctgatg ggtgcgggcc ttacgcgcgc gggacgaccg acggtgacca
     6961 tgtagcggac cggccgcccg tcgtgcgggc cttacgcgcg cgggacgacc ggggcgagtt
     7021 ccagggtcca cggtgctgcg gtggtctcga cacgggtggc ggcagcgtag ccctgccggg
     7081 cgtggtccaa caaccgttcg gcgattcgcg gccccagcac cacaccggag tcgaaactgt
     7141 acacaaaggt gagtgacggt aacgggacaa cggcggcctt ctctgaggtg atgaagaacc
     7201 gttcgaaaag atcggcgtcg atgaggccga tgtgcagcgt ctgcatgccc agcgaccggt
     7261 tgtggggatc tcgcagctcc agcagccggt gtaggtggtc ggccagggcc gggggcagag
     7321 tggtccgctg atgggtgaga cgccggtctc gggaaggccc tcagggggct gtcacgcccc
     7381 ctgagggctt cgcacccgtc acacggcctt gtcggccctg acgtgtattt cgatctgttc
     7441 gaagatgtcg gcgtcggttt cctgctgcca ggccggcagg tcgtcccagt cggcgacata
     7501 ggagggcttg gggtcgggaa agtgcttgta gatctggccg atccagcaca gggcgacgaa
     7561 ccggcccttc tgggatcggg tgagtttggc ggtggcgccg ttggtcgtct cgacgaaggc
     7621 ggcgacctgg tcgtagacgg cggccgcggc ggcccgttcc cagtcgggag tgtcttccca
     7681 gggagcgatg taacccggtt tggggtcgcc gggatagtgg ttctttaccc cggcgatcca
     7741 cgcgtcgcga aacagccggc ctcgctcgtc gtgcacttca actcctctgt cgattatccg
     7801 gaaactgcag gtctggtgag ggcggtgatg tcgtcgttga gccgacggat gcgtctgtcg
     7861 cggagcagcg gtagcagata ctgctggagc cctcgcagtt tgcggttgat cacacccgat
     7921 ccggtctggc gagccgcctc caccgcctcg gcggtgaagg ccaccacctg ctctgggtct
     7981 cgacgctgga cgccgagaag cgcgaggtcg gtgagcacgc ctgcacggcg tcgcacagta
     8041 aggggtccgg tcagggcctt ggtgagcgct gtctcggcga ggtcggaccg tcccagtgcg
     8101 acatagcagg tgccgcgctc ctcagccagg cgcgagccgt cgaagcgcag ccagccaccg
     8161 ttgtggacct ggccgggcag gtccaggacc tgctctgcgg tgtccaaagc ccgctggcag
     8221 gcgtcttggt ctccgagacc ggcgaaggtc tcagcctgca cggcagcgac ccagtatcgg
     8281 gtggacagtg tcgagtcccc gcggtgtgca agggccgtgg cgagttccag caaagggacc
     8341 gcttggggga actgccgttc atagaccgca acgaacgcgt gccgcgtcag tgcgcacgcc
     8401 cagaggtcga acgctccggc ctccttggcc gcagaagcgg agagggagta gcagtgggcg
     8461 gcgtcggtgt agtggttgcc gtcgaagaag atctctccag ccaactggaa caggtccgcg
     8521 gtcagaagac agagccgctg gcgggcggcc tcgccgtggg gctgtttgag cttgtcggtc
     8581 agcacgtcga gttgggtgcg caccaggggc agcacctggc ttttggacgg ggtcaacccg
     8641 aagacgcgcc ataggttgct gttcaactgc gtgtactcgt ccagcgcggt ggcatccagg
     8701 tgccccgacc gtcctggaat agaactgatc gcttggtcga tgcccggtac gaacccggca
     8761 gatggcaggg ccagcagtgt gccagtgaca ctgaacaggc gcagcagttc acggcggttc
     8821 atgtcgtcat tctccggagc acccgtctgg ccgggccaca ccgggagcag actgcggtcg
     8881 ttttgcggat ccgggctggc cttcctggag agagggcgct gggggagtgg ttgtcccacg
     8941 ggaccgttcg agtgaaaccc ctcgacggcg ggagtggtac aggttctcgc tgagatgtcc
     9001 tcagtatccg acgtgtcgag cggtgcgcct gcacccgatg gtcccgccct catagtggaa
     9061 gctggaggga ggataccgag gccttccaga gccctgcgct tcttggccgc atcgcgcagg
     9121 gagcgcttcc ccgattccat ctgcgagacc atgccctggg acaggccggt catgtttccg
     9181 atggcctctt gcgtcaactc cgtatgggtg cgcagcagcc gcacgatccg cgtcacatcc
     9241 gagcgcgcca ccgcctcgcg gacgtcagcg cgctgccaga aagcgacggg aatgcactcg
     9301 catctcccct cggcacggtc gtgcccgcag tggccgcaga tcacggaggc catgatctcc
     9361 tacaggatcc ggggagtcca taacagatta ttacggcctg cagcctggcc tggagtctcc
     9421 cagccccgca gaccagcgca gccagactgt gcgagcacac aacaggttct gcttcagtag
     9481 gcggggaccg agacggggtt cacatgtccg ttgagtgtgg cctggctggc gtaaaagctg
     9541 gagaagctct ctaggtcgac aaggggatct actagggggt ttctttcgaa gatcgaggcg
     9601 ataggaatat tgcaatttat tgcatttatt gctggagttg tatttgtcta atgcggtgcc
     9661 cggggggaca gtgtagagcg ctggcgggat gctcgctcga ctcagaagca agtgtcttca
     9721 acaaactggt cagaataagg agaacgaaat gagtaatacg gttgctgctg aaccgtctgt
     9781 ctccgaagac cccttcgcgc tcgatgtgca gattgtcacc gacattcccc cgggagatcc
     9841 cctgttcgcc tgcggggaag gaaccaacga cggctgccaa ccgacctgcg cctcggcttg
     9901 cgtcaccggt ggagtctgat gcctgctgat ctgggtgctg cccggggcga gggggccgag
     9961 ctccaggcag cctcttcctc tcattgcttg gagagacgaa atgggtgcca ccaccaagtt
    10021 ggcaaggctg taccgacaca ccggtgcggc gctgttgcgg gccgccgccg tccccttgtc
    10081 cacctcttcc ctcagttggc cggatctcac cgaccccaca gcaagccgag cttggctggc
    10141 acgggtgtgg gatgatccgc gtctcgcgga agccgtggga caagccagcc cttcactgga
    10201 aaagactgtt gcagtccttc gaactgggaa ccccgttcga gacaagcagg tccgtagcgc
    10261 ctccctgtcc accgtccgct acttacttcg tagcatcggt cgtccgacac cctttggact
    10321 gttcgcagga gttgctccag tcaaactggg cccaaccgca aaggtggcct gggggcacaa
    10381 ccaccgggcc gctgctcgtg tcaacaccga atggctgatc gacatcatcg aacaggccga
    10441 aagctgcccc gaattactgg accgactctt cgttgtgctc tcagacctcg ctcaccgccg
    10501 tggccggcga ctcgaagtgc cgcgaggacc gaaccgggtg accttgaact acacccgtgt
    10561 cgttgccgta ctctgcgaca gagccaccac cccgatccgt ttcgctgctc tcgtcgacat
    10621 gcttgccgaa gaattcgccg ttgatcggga cagagttcga agcacgctca cagaactggt
    10681 aaaaaacggc tgcttgatca ccaacttgcg cgccccgttt acagttaccg acccgctagc
    10741 ccacgttgtg gaccaactcc gcgaggctgg cgccgacacc gtggcacaca cagccccctt
    10801 actccgcgcc cttgaggaaa tccaaaacga actgcaacac cacaatcatc cagccaccac
    10861 cccgcaagat cagaaacact cccgagcact ggtcaccagc gcgatgagag aactgtcccg
    10921 ggctggacgc atgccgctgg cactggacct gctgctggat tgccaggtcc gacttccccg
    10981 tcaagtagcg catgagatgg agcgagcagc aagcgcactg ctgcggctga cccgtcaacc
    11041 caccggagaa aagcctggca cgactaccat gcggcgttcg tcgagcgcta cggcacagga
    11101 accctcgtac cactcaccga tgtcctcaac cccgactccg gactcggcta cccggctgga
    11161 taccgcggca gcgtgttccc cctaccagga gacggatcca cgacacgaga tgaacgactg
    11221 ctgtccatgg cttggcaggc tgtggctaca gacagccgtg agatcgtcct taccgacgca
    11281 gacattgacg ctttgagcaa cggagactgc gacccccacc gcattcctcc acatgtcgaa
    11341 ctctccgcac gcatccacgc agccgacacc gaagcactga accgcggcga tttcctcatc
    11401 accgtggccc ccgctcggtc tgcgggcaca ctgacctctc gcttcacccc catcgccacc
    11461 ggcagcggcc tggccgaggt ttaccgggcc ctgccctgct cgatcagggg agcactccgc
    11521 gtccagatga gcttcgggcc gctgtacgca cacgccgaaa acgtctgccg cgtccccgcc
    11581 tacctggacc acttgcttcc gctcggacag tatccatctt ccagtgccga acagacactg
    11641 atcaccgtgg acgacctggc gatcaccgct accagtgacc gcctgtacct ggtcagcctt
    11701 acccaccgca gggttgtgga accccaggtg ttccacgctc tcgccttgga caaacaagcc
    11761 ccgttgctcg cccggtttct cgcccaccta ccccgcgcag gtctggcctc ctggtatcag
    11821 ttcgactggg gaccgcacgc cacactgccg tttctgcctc aggtccgcta ccggcgcacc
    11881 atactgtccc cggcccagtg gcgcctgacc aaagccgacc tgccaccacg aggaggtgac
    11941 tgggagacag cactcgatca gtggcggcaa cgctggaact gcccgaacgt ggtggagttg
    12001 cgtgaagccg accgcacact gcgcctcacg ctccaagagc ctgcccacgt ggctttgctg
    12061 catgcccatc tcagccgaca cggccaagcc atcctctacc aggccacccc cctcaaggaa
    12121 tacggatgga tcaatggcca cgctcacgaa atcgcactgc cgttggccgc cgtatctccg
    12181 gaggccccca acccgctgtg cggccctctg ccgacggtga ccaacacgca tgggcaactt
    12241 tcgggggctg cggaagccat ttggctgtcc acgaagctct tcacccatcc cgagagaatg
    12301 actgagatcg tcaccgagca actccccgct ctcctggccg agctcaactc ccccccatgc
    12361 tggtggctgc gctaccgaag ttcgcgagaa accgaccacc tgcgcattcg catccgcacc
    12421 tccccggacc gctacggccg acaggtgcgg aaagtcgccg agtgggctca acagttgcgg
    12481 cggacaggag tggccggtgc cctgtccttt gacacctact ctccggagat cggacgttac
    12541 ggggcaggcc cagcgttgaa cgcggcagaa gaggtcttcg tcgccgacgc cgaactcgtg
    12601 gcagccctgc tgcgccagca ggccacaagc cctgtggatc ccaccgcgtc agtggtggca
    12661 aacatggtgg ccatcgtcac cggcttctac ggtgatccca cagcagcgat gaactggttg
    12721 gcgcaacgcc caactcctac cgctcctgca atcgaccgca gagtggccga cgaggccatc
    12781 cgaatcagca ccgagaccag cgcccggtct ctatggggtc gaagccacga actcgatgcg
    12841 ctgtggcaga gacgcgccga cgctttgaag gcctatcgca tggcattgcc agcggacgcg
    12901 aatatcaaca tcgtggtgga gtcgctgctg cacatgcacc acaaccgtgc cgtaggcatt
    12961 ggcccggagc acgagcgcac ctgccgtcgc ctggcacgac aggcctccct ctcctggctg
    13021 gccaggaaag gaaacggtgt ccggtgacca acgtccttcg gcacgttccc caaagcggac
    13081 tcgcccccgc tcaacgacag tccctggctt tcggtgctct tggcacagcc ctcctccaca
    13141 tcgttcgtgc ctgcaccggt gcagaggagt gggatactgc ccatcagtgg gtgaccactg
    13201 tgactcgcgg cccggtagcc gcccataccg aagccaattt gttctacggg gcgcccgcag
    13261 tcgcgttcgt gctgcgtatc gctgccaagc gcagccacac gactgtcttg gctgcactcg
    13321 atgaccacat cactgcgctc acccgggccc gactggacca ggcctacgct cggatcagcc
    13381 gcggagaact tccccgtctg ggggaatacg acttgatcag cggtttgacc gggatcggtg
    13441 tatacctgtt tcaggcccag aatgccgatc tactgcggga agtattggcc tacctggtcc
    13501 gactgaccgc aacggtcacc atcggagacc gtcgccttcc cggctggtgg acacttcatg
    13561 gcccttccga ccgcccggat ccccgatggc ccggcggtca cgccaacctg ggcttggctc
    13621 acggcatcag cggtccgctg gcactgctgg cccagacgat gctccacggc atcaccgtgc
    13681 cagccaggca gaagccatcg ctgacatcaa cagggtattg gatcgttggc ttcgtgactt
    13741 tccccatcgc ccctggtggc caggggccgt ctccgctcgg gaatgggaaa gcgaaaccct
    13801 tcaccaaacc ggcccgcaac gaccgtcctg gtgctacgga actcctggtc tggcccgcgc
    13861 tcggcagctc gctgctctcg ccctgaacac cccggaacgg cagcacaccg ctgagaccgt
    13921 tctggcttcc tgcatcaccg atgaagccca actcgaccag ctccgcgacg actcgctgtg
    13981 ccacggctgg gccggactcg tccacaccag ccgacgtgcc gcggaggact cccttcgcgg
    14041 aagtgtgctc accctggcgt tctcccgcct tcacgagctc tggagccgac gctggccata
    14101 cctgccagac acgcccgacc acaaaggtct gctggaaggc acagtggggg ccatgctggt
    14161 ccaccacggt ggtgagcatc ctgtctcccc ctcctcgccc gcctcctggt gggacgcctg
    14221 cctgttgacc accgcacctg tcacgaccac ggacccggaa ggaccacgat gaccaacgca
    14281 gccggtacac gtcccgaaca gctgcgcgac cgtatggtcg accgcatcag gaccgcaggc
    14341 cacctccgct ctccacgagt cgagcacgcc ctgcgaaccg ttccccggca tcggttcgtc
    14401 cccgaagcct ccacagagga cgcctacgcc gacaaggcca ttaccatcaa acccggcacc
    14461 gaccggccgg ccagctgtat ctccgtgccc accgtcgtgg ccatgatgct cgaccaactc
    14521 gacccgcagc ccggcgaacg gatcctggag atcggcgccg gcaccgggta caacgccgct
    14581 ctgctggccg aactggtcgg gccggaaggc cgggtcacca ctgtcgacat ccactctgac
    14641 gtcgtcgacc acgcgcggcg caccctggcc gagaccggct actcccgggt ccgggtggtc
    14701 aacgcggacg gcgtgctcgg ctacccgcag gacgccccct acgacaggat catcgtcacg
    14761 gtcggaccgt gggacctgcc ccgggcctgg ttcgaccaac tccgcgacgg cgggcgcctt
    14821 gtggtgccgc tgcactggcg gggccagtcc cgcagtatcg ccttcacccg ctacgccgac
    14881 aagctgcgtg ccaccgacag tcggctctgc ggattcatcc ccatggtcgg gaacagcgac
    14941 ggtgaacgca ccgcagagat cactgaccat gtggccctgt actgggacgc gggccaggac
    15001 atcagcccga ccgccctgca cagcgtgttc acccgctcgg agagcaccgt gtggtccggt
    15061 gtcaccgtgg ccgccaatga gcccttcgac catgtctggt tgtggctgag cgccaccgag
    15121 ccaggtacct gccgtctcgc cgcagagccc gccgccatcg acgccggcgt ctgccacgcc
    15181 gtgttcccct accgcactcc cgcgatcgtg gaaggcgact ccctggccta cctgaccagg
    15241 ccccgtcccg tcgaccagga cgacgagccc cgcttcgagc tgggggccac tggacacggt
    15301 cccgcaggaa ccgacctcgc cgaacgcctc tgcgcgagca tccgcctgtg ggaccgcgat
    15361 cgcgacgccc agcccgtcat caccgtctgg ccgactgctg ttgggcacgc ggacccgcag
    15421 caccacgaag gggtggtcat tgacaaggaa cacgtccgac tggtgctcac acaccgctag
    15481 cgctagccgt cttcaccgct tattgcaagg gctgggagtc gtcaggacag cggaaccggg
    15541 tactgccggt tcgttgctct ggcgtagtgg tcctgggcca ctccgaccac gaggtttctg
    15601 tgacaagcac tgttgtgaac cgcggctccg ccgaggccgc ccgcgccgag gagctgcgct
    15661 ccgtcctggt cgaccgtttg tgcggggacg gcgtggtccg cagcgctgcg gtggaggcgg
    15721 ccctgcgccg ggtgccccgg catctgttcg tgccggggac gtctctggag gaggcctatg
    15781 ccgatgaggc cgtctacacc aagcgcgacc ctgacacggg ggcttccatc agtgccgctt
    15841 cccagctgag gatcgtggcg atgatgctgg agcagctcca ggccgcgccg ggcatgcgcg
    15901 tgctggagtt gggcgcgggc accggctaca acgcggccct gctcgccgcc ctcgtcgggc
    15961 cggagggccg cgtcaccacg gtggacgtgg acgacgacct tgtcgcgggg gcccgggacc
    16021 acctggccgc cgcgggcgcg cccaacgtcg aagcggtcct cggcgacggc gccctcggcc
    16081 accccgacag cgccccctac gaccggatca tcgccaccgt cggcgcctac gaggtgccca
    16141 cggcctggct ggaacaactg gctcccggcg ggcgcctggt ggtgccgctg cgtctgagtg
    16201 gcgccgtctc ccgcagtatc gtcttcgagc gcgccgagcg tggctggacc agccgcggca
    16261 gcgaactggc ggtgttcatg ccgctgcgcg ggatcggtga cgacgcgcgc cgcgtcatcg
    16321 acctcaccgg ggacgggcag gtgaccctgc agacccacgg ggacaacacc gacgccgatg
    16381 ccgatgggct ggccggtgtg ctgggcgccg gccgctgcga ggcgtggagt ggggtgtgct
    16441 tcgtgccgcg ggagtcgttc gagtggctgt acctgtggct gtcctgccgc ctggccaacc
    16501 cgctgatgcg gatgaacgtc gaacccgccg cccgggacag cggactggtc gcgccgatgt
    16561 ttcccaccac ggccatggcc accacccgcg gcggcgacct cgcctacctc accatccgag
    16621 cagccgagcc cggtcccgac agtgccagac ggtacgaggt cggcgtcatc ggccacggtc
    16681 ccggcgccga ggaactggcg taccaagtgg tcgaggaggt gcgggtctgg gaccgcgacc
    16741 accgcaacca ccaggcgcgc ttcgaactcc ccgacactgc ggtggtctcc gatccggagg
    16801 cgggccgcta cgtcctggac cgcccccgcc accccgtcac cgtcatctgg gaatgatcac
    16861 agacaccgtt gccctggcac ggcgctttcc cttggtcgcg cggtcgcgtc caccgtgtgc
    16921 cccgctcgac gcccgagtcg gcgagctgtg caggctcgcc gactcggcgg cacgcagcac
    16981 cgacccgaca gccgcctcag ccgtgtacaa ccaggccgcc ctcctggcct cggacgcagg
    17041 actgctggag ctggcgcgca cctggtgtca ccggcatgcg atccttctgt tctgcgggaa
    17101 gcgggtggcg gaccgggacg tccacaccat gctcggcctc taccaggcgc ttgagtgccc
    17161 aggccgtacg gcggtgtttc acacacgact gggactgacc gtggtcgatg ctctcggagg
    17221 taccgaccac ccccgagggg gccgcatcgc caccgacctc atccgccgcg cgatcgagga
    17281 acgtgacggc taccgcgcca gggagatcct gacgcacccg agcggggccg cccaaccggt
    17341 gagggacgaa ctcgccgaag tgacagcctc ctgtggattg ggaaccggac gactacccga
    17401 ggctctgcac gcccttctga ccgaggcggt ggcgacaagc gaggccacgc tcacacgcac
    17461 actccgcatg gggatcgggc aggcccgcgg cgggccccgt agccggaggt gaacgatcat
    17521 gtcggcatgg ccgacgcggg acagtcccgg gcttgtgggg gccaagctgt ccaaggggtg
    17581 ttgagcctgt tggagtcctg tcagtggtag gtgtcccacc gggtgcgggt gtcgcctgcg
    17641 cggaagctcg cgtagcgggg ctcccactgg gcgcggatgc cggggttgcc ggccagttgt
    17701 ggaagcacgc tggtgaccag gacgagttca cgtagacggc ggaagaccgg gaagccgacc
    17761 caggcggtga cgtcgtagcc gtaggcgtcg gccagcgggg tgtggtggtc ctcgggatag
    17821 ttcatgcgca gccgtcccac cgcgacaggg gtgaggtccc attcccgcgg cccccaagag
    17881 acgccgtcga aatcgcacag cacgggaccg tcaggaccag ggatcaggtt gcccaggaac
    17941 gggtcgccgt ggatcagacc cgcttccagc acgtagtcca acgaccggac ctcggcttcc
    18001 actgcggcgc actgttccag cagccattcc tggtcgcggg cactgatgcc ttgggcgtcg
    18061 gcgatgcgtg cgcggatacg gggaaatgga gcccagtcgg gtagtgcgaa gtcgggttcg
    18121 ggcagggcgt ggaaccggcg gagaatgcgt cccaggtcgg cccctgtggg cgcgggaccg
    18181 gtgacgggta cttcctccca gaacgttgcc acgtggcctg cggcctcgac gggttggtcg
    18241 atgccggaca gcaggcgcac agcgggcatg tcttggccgg tcagccagcg ggccacctgc
    18301 acgaccgtgg tgatgctggc cctagcggcg cgggaaccgg cgatgcgcac caccaccgga
    18361 gccgtggcca gccgcagtgc ggcgttgttg gtgaacttga tcaactgggc gccggtcgga
    18421 tcgaggccga cacggtcgca cagggctgcc acgaccgtgg ggagctcggc cagcgtgaga
    18481 ccgcctgcgg aagccgttgg tgcagaaggt ggtgtgctca tcgtgtccgc agcgtagcaa
    18541 tccgttccac caggtcggcg gcatcgatgg tgtgtactgc ctgtgctgca gcagccaaag
    18601 gggcaagccg gtcgatgacc cgggcagagc acagacgctc agccaagtcg acagcggcat
    18661 aaccggcctc cacgccttcc gcggtatctc cgcctgtgat gtgggcagta gccaaagccg
    18721 ctagttcaaa cgcgcgactc cgactcattt ccggtcctcg ttgggagagg ctacgggtga
    18781 gactcgtggt cgcctggttg taggcgcggg gaacgagctc cactagagag gcgttgacca
    18841 cgccggtcat ggcgtccagg tcggcagtgc cgaagaaacg ggcccaggac gggacacggg
    18901 tgtggtcggt acgggtgaat tcgtcctggg aacgtcccag cgcttggagc gcgcggcttg
    18961 ggtctcctgt cagggcatag gcccaggcct cgttggcgtg caggatcgcc acggttaccc
    19021 cgcaaccgga gttctgtccg gcgatctgtc ctaactggaa gaagcgcagg gcgtcgctga
    19081 tcagtccacg gtggaggtgg aggcgtccca tgcggtagag gacgttggcg gagagagaag
    19141 gctcctgggc atggtgagcg tgttccaggg cacgggcgaa gtgccaccgt gcggtggagt
    19201 ggccgccgat gtcgaactct gtccatcccg ccaggttgtg gagatcggcc agagcgaggt
    19261 gcagtcgagc tttgacccta tcgttctccg aggccgcggt aaggaaacgg cgggcgtggg
    19321 cggtgtgagc gttgatcgcg tcgcggcatg ctccaccgcc gtaccggtag tctgcggccc
    19381 tcaaggagtg ggtcactgct tcgaggtgtt ccacgttggc catggtgact cgctgtggaa
    19441 cctgagccgc ttctatggtg aacggtgaag tccaccggtc tggtgtctgg ggaaccactc
    19501 ccatggtgac ctgggctgca taggcgatca ggtcatgcac ttccgtggtt tcgctgcata
    19561 cctctggtcc agagaagtgg gtgacatatt cgaggactgg ctgaggcgtc cccagtcctt
    19621 ccaaggctcg gcgtttcttg atgggggatc gcagggagcg cttgccggat tccatctgcg
    19681 agaccatgcc ttgggacagg ccggtcatgt tcgcgatcgc ctcttgggtg aggtcggtgc
    19741 gggcgcgcag cagtcgcacg atccgcgtca catccgagcg cgccaccgcc tcgcggacgt
    19801 cagcgcgctg ccagaaagcg acgggaatgc actcgcatct cccctcggca cggtcgtgcc
    19861 cgcagtggcc gcagatcacg gaggccatga tctcctaagg aagccaggta ctccataaca
    19921 gattattacg gcctgcagcc tgggctcggg tctcccagcc ctcgcaaacc agcgcagcca
    19981 gactgtgcga gcacacaaca cgttcttctt cagtggacga ggaccggaac gagttgggga
    20041 ggccgcatgc ctgctgggtt cgcggagccg gagagaatcc tcggatcgac gaggagatcc
    20101 accgcaggat caccgacctg gccgacccga gccgtccccg ccactggcac ccctactgac
    20161 cccgccgtat cggcaacctg ccgacgaccg ggactgagcg gtccaggaat tctcgcaccg
    20221 ccgggtgggc agagtgcgcg gtgaagcgtc ggacgagcga gtcgagatag ccgcggacac
    20281 gggccgaagc ggtccgctcg accagcggaa ggacagctgt gccgagtgcg gcggcctcgt
    20341 cgagttcgtt ctgagcgagt accgccgcca cacgcaccat gtgggagaag gagcggctgc
    20401 gcgcgtagtc gtcccccgtg ctcagcctca ggcactcctc ggcatgggta cgagctgcgg
    20461 cagcgcgacc gaggtcgcgg tggcagtggg cgagttcgtc ggtgaactcg caggcgtcga
    20521 agtatccgat ccactcagga tcctcctccg gcctgctgcg gacgaactcc gtctcggccg
    20581 cggccatcgc ccgggtgcag gccgccgcgt ctccggcagc ggcggtcgca cgggcctcca
    20641 ttatgaggaa ccgcgccttg atcgatccgc gttagccccg ccactggcat ctctactggt
    20701 tttagtggtt attccaatgt ttgagacatt agagtcatca cactttattg caatcattac
    20761 cggagttgtg cttgtccgat ccagcggttc gaggaacgct gtagagcacc gacaggaaaa
    20821 acgttctact cagaagcaag gcgtcatcgc ccctcatacg ggagcaccgg tcgtgcggcc
    20881 cggagagaga ccagttctgt gacgtcctgc tgaaagcgcg gcacgatgtg ccagagtctg
    20941 agaccaactc gccctgagcc gaggagaggc cgtgcacctg ttgaccgatc atccgggctg
    21001 gaccgactcc ggagtccgcg tcgtccgcac gagcgacggg ccgcgaatcg tctccgctgc
    21061 cactctgccg ctccagcccc gggacagaac ggccggactc atggttgacg tccacgatcc
    21121 cgtaaacctt ggcgaaggcg tccctgagcg gttgcggaaa gtgctgtacg ggcggggacc
    21181 ggtcgctcgg ttgcgcaacc ccgacctgtg ggatgccctg gccaccgcga tcatccgaca
    21241 ggtcatccgc gccggccagg cccgtctcat gtatcagcgg ttcagcgcag ctttcggtga
    21301 gagcgtcacc cgcgatggaa accggctacg cgcctttccc gccccggaga cggttctggc
    21361 ggtgagcgac gccgagtacg cgcgcctggg catggcgttc aaacggcgtc cgctgcgcgc
    21421 cgccgccgag gcgttcctcg acctcggtga caaatgggcg agtctgcccc ccaccgacct
    21481 ggtcaccgaa gtgcagtcgg tacaccggat cggcccgtgg accgccggtg ccgctgtcgc
    21541 cgaccacacc ggcgacttct cccgctaccc ctgcggcgac ctggcggtcc gtacttatgc
    21601 ggctcaggct gcccctggcc tggcctggcc cgacagcgaa cccgagttcg ccgcccgctg
    21661 gaagcgctgc accaccactc cccgcgaact gtcgaccctc accgtgctca ccctggctct
    21721 gggaggacgc cgtgcacagg agtacgcccc cgactgaccc catccgcggt cacaatcccg
    21781 accacgccct agacgccctg ttcgttaaca ccccgctgcg cgactacgcc cagcgtcccc
    21841 gcgtcaacga cttcaccctt cccgtgctgg gtgtcggcta catcgccacc tacgccgccc
    21901 accgcgggtt caacgtggga gtgctcgacg ccgaggcgct cggcctgtcg gtcgccgaca
    21961 ctgtcgccgc ggtcaaccgg gcacggcccc gctgggtcgg attcaacctg ctggccccca
    22021 cctacgagat ctccgcgacc atcgcctcgg gcctcgatcc cgacatcaag gtgatggtgg
    22081 gcggccacca ggccaaggcc atgcccaccc agatcctcac cgatgaacgc atggcccgct
    22141 gtgcggccct ggtcatcggc gaggccgaga cccgtgtcgc tgaactgctg gacgaccacc
    22201 accgccgcgc cgacctgccc ggcgtgatgt ggctcgaccc cctgctgaag accccggtca
    22261 ccggaggacg tcccggacat ggccaccacc tcgccccgcc cgtcgacgga ctaccgttcg
    22321 tggaccgccg ctacctcgtc caagacccct actctgacgc agggcgatgg gaggccgcca
    22381 tagtcgcagc gcgtggatgc ccctacgact gctcgttctg cggtgccgct gtctcggcca
    22441 atcctgacgt caccatccgg gtgcgcagcg ccgagggcat cgtcgccgag atggagcagt
    22501 tgcgcgacaa cctcggcgtg acggcgttcc gcttcgtcga cgacctgttc ctgggcgccc
    22561 ggcgcgtcat cgaccagatg acagtctgct tcaccaaggc gcgaatcggt gactgggcgg
    22621 tgtgggacgc caccggccgc atcaacgtac tgcaccggct cgacgaagca accctggacc
    22681 tgctggcagc caacgggctg cgtgaggtcg ccttgggcat cgagtccggc agtgaacggg
    22741 tgctgaccta catcgataaa cgcatcaccc gcgacatggt ccgctctgtg atcgtccgcc
    22801 tcctttctcg cggaatcaac gtcaagggct acttcatcct aggatttccc accgaaaccc
    22861 gcgaagagat ggccgagact gtcgccctgg tccacgaact gtgggacctc gccgacagag
    22921 ctccgggccg gttccgctcc tctgtgttcg agttccggcc ctaccctggc acacccgaat
    22981 ggcgccgact gctcgccact ggccgctaca cccccacaca actgctcaac tacacggcgg
    23041 tggacctgac cgatcaggga gtggacgtgg ccctgcacca ccgcgacgaa ttcaacttct
    23101 ccaccggcat ccagttcggc gagcccaccg tcgaggaagt acgcgctgcg ctggtggaac
    23161 tgtcccgcag cgagtacatg cggagggcgg cgtgagcggt ctgttcgttg ccttcgacgg
    23221 tcccggaggc gctgggaaat ccaccaccgt gagactcttg cgcgagcgac tttccgagga
    23281 agggctgccg gtggtcgcca ccaccgaacc gtcgcactcc gcactgggcc gcttcacccg
    23341 tgcccacacc ggcgactacc gcggcctgtc cttggcctgc ttggtcgccg ccgaccgcta
    23401 ccaccacctc gacaccgaga tccgccctgc tctggcagca gaacagttgg tgctgtgtga
    23461 ccgctacctt gcctcgtccc tggtcctgca agccggaatc gacggcgttc cccccgaatt
    23521 cgtccgcgcc ctcaacaccc acgtcgatct tcccgacctg aacgtcatca tgacggcccc
    23581 acccgatgtg ctccgcgagc ggctgaccac acgcggctcc cacggccgtt tcgaggacga
    23641 tcccgccaac accgaccggg agttcgtcct ctaccaggaa gtgcttgcca tgctggaggg
    23701 tatcggcgtt cccacactgg tgatcgacac cggttctgat gtgggaacaa cggtttcccg
    23761 tctcgccgca accatccagg cgctatggtc gcaccgacat ctctagtaag ccatcccagg
    23821 tgaggccagc catgccggag cgctaccgca gcattgtcga cgtccacgtc atcctgcacc
    23881 gggacg
//
