LOCUS       NZ_CP051627            25274 bp    DNA     circular CON 21-APR-2024
DEFINITION  Thermobifida alba strain DSM 43795 chromosome, complete genome.
ACCESSION   NZ_CP051627
VERSION     NZ_CP051627.1
KEYWORDS    RefSeq.
SOURCE      Thermobifida alba
  ORGANISM  Thermobifida alba
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsaceae; Thermobifida.
REFERENCE   1  (bases 1 to 4903256)
  AUTHORS   Luzics,S., Horvath,B., Nagy,I., Toth,A., Nagy,I. and Kukolya,J.
  TITLE     Thermobifida alba genome sequencing and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4903256)
  AUTHORS   Luzics,S., Horvath,B., Nagy,I., Toth,A., Nagy,I. and Kukolya,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2020) NGS Platform, Seqomics Ltd., Vallakozok u.
            7., Morahalom 6782, Hungary
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: RA v. v0.2.1; CLC Genomics Workbench v. 11.0.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 331.0x
            Sequencing Technology             :: PacBio Sequel; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023208015.1-RS_2024_04_21
            Annotation Date                   :: 04/21/2024 13:45:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,356
            CDSs (total)                      :: 4,290
            Genes (coding)                    :: 4,246
            CDSs (with protein)               :: 4,246
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 44
            CDSs (without protein)            :: 44
            Pseudo Genes (ambiguous residues) :: 0 of 44
            Pseudo Genes (frameshifted)       :: 10 of 44
            Pseudo Genes (incomplete)         :: 35 of 44
            Pseudo Genes (internal stop)      :: 3 of 44
            Pseudo Genes (multiple problems)  :: 4 of 44
            CRISPR Arrays                     :: 12
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:37:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3519607
            Orig. end                         :: 3544881
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP051627.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25274
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="10"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25274
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25274
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15274](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15274)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(104..113)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            complement(685..1764)
                     /locus_tag="FOF52_RS15485"
                     /old_locus_tag="FOF52_15380"
     CDS             complement(685..1764)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017535380.1"
                     /locus_tag="FOF52_RS15485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_15380"
                     /product="ArsO family NAD(P)H-dependent flavin-containing
                     monooxygenase"
                     /protein_id="WP_248590658.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.2e-12, bitscore:
                     45.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTPEPGEYDVVVVGGGQAGLAAGYFLRRSGLTHVILDAEHRPGG
                     SWQHYWDSLRLFSAAEHSPLPGWWMPEQEGEEYPTADHVVRYLTAYEKRYALPVRRPVR
                     VTAVRRAGRRLAVESDAGTWRARAVVSATGTWRAPYVPHYPGRDVFAGRQWHTVDYRRP
                     DPFAGQRVLVVGGGNSAAQILAELSLVADTVWATLRPPRFLPDDVDGRVLFDAATRQLR
                     ARAAGADGDGGTGEQPGGIVVVPPVREARERGVLKAEPVFARLTERGAVWPDGTAHDFD
                     AVLWCTGFRPVLDHLAPLGLRGPHGRIATEGTRSTAEPRLHLVGYGDWTGPASATIIGA
                     GRAARNAVAEITAALRADP"
     gene            complement(1922..2761)
                     /gene="erm"
                     /locus_tag="FOF52_RS15490"
                     /old_locus_tag="FOF52_15385"
     CDS             complement(1922..2761)
                     /codon_start=1
                     /gene="erm"
                     /gene_functions="resistance (resist) Erm38"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017619059.1"
                     /locus_tag="FOF52_RS15490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_15385"
                     /product="23S ribosomal RNA methyltransferase Erm"
                     /protein_id="WP_248590659.1"
                     /transl_table=11
                     /translation="MSSPSRHGGRHELGQNFLTDRAVIADIQRLVAATRGPIVELAAGD
                     GALTVPLGRLGRPVTAVELDPRRARRLRRRVTGNVTVVNDDLLRFRLPNVPHVVVGNLP
                     FHLTTAALRRLLAAPHWRTAVLVVQWEVARRRAGVGGATLLTASWWPWYEFAVHARIPA
                     RAFRPVPSVDGGLLTATRRPEPLVADRKGYQRFVSRVFTGPGRGLGEILLRTGQVPRPV
                     LRGWLRAHRVSPHALPRDLTARQWADLWTRVRPDADPAGPRPRGLTASRRDGHIEEW"
     misc_feature    2899..2914
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            complement(2911..3660)
                     /locus_tag="FOF52_RS15495"
                     /old_locus_tag="FOF52_15390"
     CDS             complement(2911..3660)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018028.4"
                     /locus_tag="FOF52_RS15495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_15390"
                     /product="RDD family protein"
                     /protein_id="WP_248590660.1"
                     /transl_table=11
                     /translation="MHPQQPTPPPPPGDGVPQFTPPPPAPHPPGPPAAAHPRVVAAQTP
                     PDRLYQVPSPAPGHPPVLPLADPFMRLLARIIDGFVAFFCNIVAGLAATAGLLLLNGGD
                     MDNAPLWQAPILVGALVGSGFCYEWLMVRAAGQTVGKRLLGLRIVDAADGGRLPSGRAA
                     LRALCYSPSIYYPISWFPVLAQLNVLWMLWDRPGRQCLHDKLVKTVVIDEKQLHALYPP
                     QPPAFPPHPPHPYGGPHPQYPQPPHGG"
     tRNA            4115..4190
                     /anticodon=(pos:3523755..3523757,aa:Lys,seq:ttt)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FOF52_RS15500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="FOF52_15395"
                     /product="tRNA-Lys"
     gene            4115..4190
                     /locus_tag="FOF52_RS15500"
                     /old_locus_tag="FOF52_15395"
     misc_feature    4850..4860
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: strong, score: 22.05"
                     /tool="antismash"
     gene            complement(5048..6121)
                     /locus_tag="FOF52_RS15505"
                     /old_locus_tag="FOF52_15400"
     CDS             complement(5048..6121)
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (176-308). E-value: 1.5e-12.
                     Score: 39.1. Matches aSDomain:
                     nrpspksdomains_FOF52_RS15505_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012428.4"
                     /locus_tag="FOF52_RS15505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_15400"
                     /product="aminotransferase class III-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_248590661.1"
                     /sec_met_domain="Aminotran_3 (E-value: 6.8e-11, bitscore:
                     39.4, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLKTRPAEQRRVAAGGDGACVCTVDGRWLLDATAAGDRVILGYG
                     WDPLRALARTARLPLLPEGYTALAELLLVADLHAVTGMAHAVLVASGTRAADSLARIAA
                     TGPGGQSGALVHVVFDHGPARLRLTGSSSRDASAVPAPVTTGDLVERVRWAIDRAHATG
                     TPVQGIVVRLLTAVPPEVETMRKLRGLCDEYGLVLAWDETPVGLGRSGALTLLGGLPAD
                     ARPDAAALGDSLVAGYGACGVLLAAPRLAAAVEHAADHCPDQDPHPFAASVAAEVLHHL
                     TGHALSAQAAKAGAFLADQIERRLADRIHTTRYGLDLQVVPLATDTAPAPPVEAVVAAA
                     ATATCSWALPTGRRACA"
     misc_feature    complement(5075..5077)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(5198..5593)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FOF52_RS15505_Aminotran_3.1"
                     /evalue="1.50E-12"
                     /label="FOF52_RS15505_Aminotran_3.1"
                     /locus_tag="FOF52_RS15505"
                     /protein_end="308"
                     /protein_start="176"
                     /score="39.1"
                     /tool="antismash"
                     /translation="VPPEVETMRKLRGLCDEYGLVLAWDETPVGLGRSGALTLLGGLPA
                     DARPDAAALGDSLVAGYGACGVLLAAPRLAAAVEHAADHCPDQDPHPFAASVAAEVLHH
                     LTGHALSAQAAKAGAFLADQIERRLADR"
     gene            complement(6118..6753)
                     /locus_tag="FOF52_RS15510"
                     /old_locus_tag="FOF52_15405"
     CDS             complement(6118..6753)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FOF52_RS15510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FOF52_15405"
                     /product="hypothetical protein"
                     /protein_id="WP_248590662.1"
                     /transl_table=11
                     /translation="MGELMSHRARIPESLSSSEHSPMTDWWLPPPWVEVDLTGLSRAQQ
                     IAYAFVEGVMRKLGLDADTAHNAGWASSELVGNAIRHATRPHRLRLHGTTGKSITVCVT
                     DGLPSPVDIQLHAASPLELGLDDIDALPFDAPEIEHRRGLSTVAAISQGRLGCLIAPGE
                     KGVWFMLPILDSAVLAPQQVESLLKSLDCPPVTWAVSPATAVGLGSRP"
     gene            6919..7773
                     /locus_tag="FOF52_RS15515"
                     /old_locus_tag="FOF52_15410"
     CDS             6919..7773
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.3"
                     /locus_tag="FOF52_RS15515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_15410"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_248590663.1"
                     /transl_table=11
                     /translation="MARQPVMPTVGKRQLGRELRSLREASKFTLDRVAEELDWAKTKVH
                     NLENGHWTRGNLTDLRALLDLYGVTDPQRRTALEDLMRNAKKRGWWVEYGDALDGALPA
                     FEDEASQISSYEPAVIPGLVQTPEYTAALLRTYPFLTAGEVERRVEARMQRQRILDRDT
                     PPEVSFVIEEAVVQRLVDTPVARAQIQHLIDVAEAANRVTLQVMPLRSGLHGALGPSFT
                     LLDFAGDFDLSIVYTESAARSAYLEDKADVALYRTMFTHACGRALPPEKSIELLSGLLR
                     QSS"
     gene            7787..7996
                     /locus_tag="FOF52_RS15520"
                     /old_locus_tag="FOF52_15415"
     CDS             7787..7996
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011292226.1"
                     /locus_tag="FOF52_RS15520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_15415"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_248590664.1"
                     /transl_table=11
                     /translation="MDLFPTDYEPLFRKSNYSTAAANCVEIADLPDGQHAVRDSQNRHL
                     GGFLFPTQAWGAFLASVKTGEFDA"
     gene            8028..8489
                     /locus_tag="FOF52_RS15525"
                     /old_locus_tag="FOF52_15420"
     CDS             8028..8489
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.3"
                     /locus_tag="FOF52_RS15525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_15420"
                     /product="DUF5753 domain-containing protein"
                     /protein_id="WP_282574074.1"
                     /transl_table=11
                     /translation="MRRSPDQIEGRVTVRMRRQQRLTDDPPLAFNVVVNEAALHRSVGG
                     TDVMREQLKFLLERMELPNVDARILPFESGAHTASEGSFVIMKFPSLLENVTFGDVVLI
                     EYRVGALYLEAEQETQPFSRVFERLQATALDPRESAKRIQHLLNSRYGR"
     gene            8501..8704
                     /locus_tag="FOF52_RS15530"
                     /old_locus_tag="FOF52_15425"
     CDS             8501..8704
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017626985.1"
                     /locus_tag="FOF52_RS15530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_15425"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_248590666.1"
                     /transl_table=11
                     /translation="MTLDGSPLIWRKSSYSGGAGGNCVEAARLPSGGMALRDSKHPEDA
                     VLHFTRDAWTAFRKALCDGGLF"
     gene            complement(8842..9855)
                     /locus_tag="FOF52_RS15535"
                     /old_locus_tag="FOF52_15430"
     CDS             complement(8842..9855)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FOF52_RS15535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FOF52_15430"
                     /product="hypothetical protein"
                     /protein_id="WP_248590667.1"
                     /transl_table=11
                     /translation="MADLCDRARAAERDSDLAAASAVHNLAALLASDCGLPDLARQWCH
                     RHANVYLRAHPLGAQAARHALEPLINLARLHIRDGRGGCASDLIDTLYTAVSSCASATV
                     DSVELPARLTDSREAHQQVRRWLWAVMLATTSRALATAGLWQEAYKRLRDHRGIGRRML
                     DGRQVAVIAHAASGDGDGALALLEDTEPGEPWENAVTACLTIRCRRSGSDDAGLGPLLD
                     LYYMLDTSAPGLAVFHTRLGLSFIDALGTADNPHAYRIAAGLIRRTAASQDGYAARDLL
                     DHGGCRNLLTSAQAQELNALVDTCALGRGTLPAALLDDLTTALTSAEETITRIVSR"
     gene            complement(10001..10909)
                     /locus_tag="FOF52_RS15540"
                     /old_locus_tag="FOF52_15435"
     CDS             complement(10001..10909)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="FOF52_RS15540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_15435"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_083948133.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.2e-42, bitscore:
                     143.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNHAPERVREDALWHQVTVNFADYSVAEHVGAVHIGPIMTGAETA
                     GRTRAWFFVRKAPCWRIRFLVAHGTGQETVVFLHERLDALRDGGHIAGWAPTIYEPEIH
                     AFGGPLGMELTHRLFHVDSRHVLAYLGRQDVPPTGHGDQRRELSVLLCSMLMRGAGQDW
                     YEQGDVWARVAGIRPDPPDIPAERMNRLEADLRRLMTVDAGPTSPLLRENGPLAFLTEW
                     AVAFAEAGQRLGGLARNGLLTRGLRAVLAHQIIFHWNRLGLPYTVQSLIAHTAKTVVLD
                     RDEWPTTMTPLRLPGARGDRK"
     misc_feature    complement(10172..10174)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(10325..10327)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10941..12188)
                     /locus_tag="FOF52_RS15545"
                     /old_locus_tag="FOF52_15440"
     CDS             complement(10941..12188)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="FOF52_RS15545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_15440"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_068756308.1"
                     /sec_met_domain="LANC_like (E-value: 9.2e-43, bitscore:
                     144.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSPCSEALAAASAVASRLVDPSVIGSRGVASGGRGRRRPQSLAG
                     GAAGIALLHIERAYTGHGDWTTVHTWLSAAVHEELSAGPNAGLYFGVPALAFVIRAAAG
                     RSSRYRHALTQLDTAITAMTRHRLSQAHTRIDQGIRPRMAEFDLVRGLTGLGVYHLLRH
                     PDHEITQAVLAYLVRLTEPLPEHADDLPGWWTDVSLNGDPAPDFPGGHGNLGMSHGIAA
                     PLALLSLAALKGITVEGHTEAIGRICAWLDVWQQEHPCGPWWPGFVTREQARRKHVEAS
                     SRQRPSWCYGTPGLARAQQLAGLATGDLERQRTAEAAMLGCLRDPAQLNLLPDAGLCHG
                     TAGLLQAAWRMADDASTPDIAQELPRLAARLLSQLPSLPEDVEFLDGHAGVALALHTAG
                     TGTAPISRWDACLLLI"
     gene            complement(12185..15274)
                     /locus_tag="FOF52_RS15550"
                     /old_locus_tag="FOF52_15445"
     CDS             complement(12185..15274)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="FOF52_RS15550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_15445"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_341849688.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 8.6e-208,
                     bitscore: 689.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 7.4e-19,
                     bitscore: 66.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 7.1e-34, bitscore:
                     115.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLYRFVDAAVVRAAARCPGSVPPWPDLTDDAEKNLTSWVDWLRQ
                     VWASDGFAASVEIASPDLARRVQEVCQGSRVRRQEVRRAVLSLIRYLLRSTSRATPFGL
                     FSGVAPVRLGHTPAVRFGGGHRAVARVDSTWLDGVITRLEAIPELRYRLLVVRNNLAFV
                     RDGRLVVGCWQSGAVHGTGPAEVSVRYTEAVHTVFQAAQTPVRLGDLADKLASNFPDKP
                     DSVINEMLTRLVEHRLLVTSLRPPMTVTDPLGHVIEALTAVQADTVQGAAGLLDELCGI
                     HADLLHHNATPPLRGRSLRSHVSRRMAALCTAERPIAVDLRLDGDLVLPHAVVREAERT
                     AEALARLGPHPHGTPAWQDYHRRFCERYGLGSLVGIRELLDADSGLGFPHGYRNSRLAP
                     PSVPGLSKRDMALLVLAQNAAVQQHTEVVIDDALVDNLAAASLGEYRVQPHTELRCRIY
                     SPSTGALGRGEFRLAVTGMSRAAGTTAGRFLDLFDTGDQERMFRAYAELPAVCQNALRV
                     QVSGPTVSRRAENITRSPAVLPLLVPLAEQCPDGKEAVSLDDLAVTADAQRLYLVSVSR
                     RQPVEPILFSAVELTHHAQPLLRFLCEISTARTAACVPFSWGAASRLPFLPRIRYRRSI
                     LSPAMWTLTATDFPGSAEPWRNWKDRWDAWRDQFRVPASVYLGDGDRRIRLDLDESAHL
                     AVLRADLARNGHATIREAPEEDEMGWIDGRAHDIVIPLAATAPPAAPQRTWSRCVLSRA
                     HGHLPGSSEWLYVKLYGNPGRQTALLTSHLPALLAAWEKEPEWWFLRYHDPDKHLRLRI
                     RLREADDFGQVAARVTAWTTELYERGLVSQVQFDTYYPETGRFGQDVAMAAAESVFAAD
                     SAAAVAQLRAVDHREGPHLHAVTAASMVDIAVTVAGSVSDGMRWLIRHWRASSAPAPSR
                     ETRDQMIRLADPSRGRSALLEVPGGEDIAASWELRRAALLRYRAALTAEKQISPDTVLA
                     DLLHLHHARMVGISPDSEWACRRLSRAAALSWTARTQGAL"
     aSDomain        complement(14537..14815)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FOF52_RS15550_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="4.80E-21"
                     /identifier="RREFam001.1"
                     /label="FOF52_RS15550"
                     /locus_tag="FOF52_RS15550"
                     /protein_end="246"
                     /protein_start="153"
                     /score="66.3"
                     /tool="antismash"
                     /translation="LVVRNNLAFVRDGRLVVGCWQSGAVHGTGPAEVSVRYTEAVHTVF
                     QAAQTPVRLGDLADKLASNFPDKPDSVINEMLTRLVEHRLLVTSLRPP"
     misc_feature    complement(14996..14998)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15345..15512)
                     /locus_tag="FOF52_RS15555"
                     /old_locus_tag="FOF52_15450"
     CDS             complement(15345..15512)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019608870.1"
                     /locus_tag="FOF52_RS15555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_15450"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_083948129.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 7.2e-18, bitscore:
                     62.2, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVQTPQTAIDGENTQFDLDISIVESGPVINDLMRLTDDGCGTTC
                     ESACPAQSGC"
     misc_feature    15502..15515
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.42"
                     /tool="antismash"
     gene            complement(15577..16821)
                     /gene="fxlM"
                     /locus_tag="FOF52_RS15560"
                     /old_locus_tag="FOF52_15455"
     CDS             complement(15577..16821)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="FOF52_RS15560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_15455"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_068756887.1"
                     /sec_met_domain="PCMT (E-value: 1e-43, bitscore: 147.5,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREHQDTKTSSTGETDRAEYLREKMVGELRDLGAVRSDPVAAAFS
                     VVPRHLFAPGEPLERAYATMTTLHRKQDGAGTATSVVSASEIQAVMLEQARIEPGMRVL
                     EIGSGGYNAALIAELVGRTGRVVSVDIDPEITGRARRYLDATGYGWVDVALGDAAHGVP
                     EHAPFDRIIVTAGAWDIPPAWIEQLTEDGRLVVPLRLRGLTRSVAFERAGERLVSRDYQ
                     LCSFVPMQGAEAHSEQVVTLDEDRVSLLIDTDRPVDTDGLRKALLGPRTERWGGMEFGD
                     SEPLHDLDLWIATVADGFGLVKATKEAVDSGLTSRSALYGGKAIVSGSSFVYRASARPV
                     DESRTRFEFGAYAHGPDSERLAEEYIDHIRTWDRDHRGGPGARIEVFPAATPDAALPAG
                     RVVDKKHTRIVVSWP"
     misc_feature    complement(16951..16965)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.53"
                     /tool="antismash"
     gene            17754..18290
                     /locus_tag="FOF52_RS15565"
                     /old_locus_tag="FOF52_15460"
     CDS             17754..18290
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FOF52_RS15565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FOF52_15460"
                     /product="hypothetical protein"
                     /protein_id="WP_248590668.1"
                     /transl_table=11
                     /translation="MAEQAAAYLRGEMDWSSPKELSVYGTLLLPGAVAAAREGDRRAAR
                     DYLEESEKVALRLGIDRNDLWTSFGPTNVAVHRVVVANSLGDVDAAIQLGRRIDPSGLP
                     IERQVRHALELASAYVKRNQIDAAVGQVLEAEKLSPEQTRRHVMSRQIVTAMLQTKSGK
                     RNRDLVSLAIRMKAL"
     gene            18312..18782
                     /locus_tag="FOF52_RS15570"
                     /old_locus_tag="FOF52_15465"
     CDS             18312..18782
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017602585.1"
                     /locus_tag="FOF52_RS15570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_15465"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_248590669.1"
                     /transl_table=11
                     /translation="MSVDPAESFARPRVAAGVLFFDEQDRVLLVVPSYKHYRDIPGGYV
                     EHGETPRQAAQREVREELGITPPLGRLLVVDWAPTPTEGDKQLFVFDGGPLEQEYLDAI
                     ALDPAELTSYEFCDATRIHEHTIPRLARRITQAIQARVENTTRYLENGAPVG"
     gene            <18804..19187
                     /locus_tag="FOF52_RS15575"
                     /old_locus_tag="FOF52_15470"
                     /pseudo=""
     CDS             <18804..19187
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014724.4"
                     /locus_tag="FOF52_RS15575"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_15470"
                     /product="YdcF family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="AIPVEPDAADTGQNIAFSRRVLAGAGLRPASVMLATMPSMQRRGY
                     ATTRKVWPEVEVVCACEPVAFRDSLVGIGDDRLVIDTMVGDPQRIIEYPDRSFAVEQHV
                     PDDVHTAYQALVKAGCTSRLIGA"
     gene            19266..>19541
                     /locus_tag="FOF52_RS15580"
                     /old_locus_tag="FOF52_15475"
                     /pseudo=""
     CDS             19266..>19541
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017540661.1"
                     /locus_tag="FOF52_RS15580"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_15475"
                     /product="flavoprotein"
                     /pseudo=""
                     /sec_met_domain="Flavoprotein (E-value: 5.2e-05, bitscore:
                     21.1, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADQRVCSLVVSGSSAPEGVPELVELFQEDGWRITVLSTPAGTRF
                     HDLDRLAELTGEPVRVDFRRPGTGKSLPPADVVLACPLTFNSTNKFA"
     gene            19580..19945
                     /locus_tag="FOF52_RS15585"
                     /old_locus_tag="FOF52_15480"
     CDS             19580..19945
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017573676.1"
                     /locus_tag="FOF52_RS15585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_15480"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_248590671.1"
                     /transl_table=11
                     /translation="MAAGGPLPHRDRPWTKSSFSTTGEGCVQVRATGNGHVIVGDTKNP
                     NGPVLTVTNTDWTTFLDQVATGTSDYSGRLIPVFQPDGGFILRDTATQATLVFTRAEWD
                     AFHAGVVHGELRPLAAL"
     gene            20870..22147
                     /gene="fxlM"
                     /locus_tag="FOF52_RS15590"
                     /old_locus_tag="FOF52_15485"
     CDS             20870..22147
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017618483.1"
                     /locus_tag="FOF52_RS15590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_15485"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_248590672.1"
                     /sec_met_domain="PCMT (E-value: 6.2e-45, bitscore: 151.5,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDVAADPENAAELRDQVVDTLIRDGVIVSPQVEAAMRRVPRHRF
                     TPEATVEEAYRPYAAVVTKKNEHGISISSVSAPQIQAMMLEQAAIEPGMRVLEIGSGGY
                     NAALIAELVGDSGQVTTVDIDQDVTARAERLLAENGYPQVRVVLADAEDGLAAHAPYDR
                     IIVTAGAWDIPPAWITQLTERGRLVVPLRLRGLTRSIAFERRGGHLLGLSARACGFVPM
                     QGAGAHQEQLLLLCGTDEIGLRFDDGLPGDPSLLDNTVRTPRLEVWTGVVVGRTELVDT
                     LQLYLATALPGFCIMAVDPALDTGLVEPNHPSFSLAAVDGGNFAYLRVRPTADDRSVEY
                     GIHAFGPQREAFAEKMAGHVRTWAREHRGGPGPQIRVFPARTPDEQLPGHLVLDKKHSR
                     VTFSWPSATAADQAVPPASSEGDDHR"
     gene            22147..22347
                     /locus_tag="FOF52_RS15595"
                     /old_locus_tag="FOF52_15490"
     CDS             22147..22347
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017564549.1"
                     /locus_tag="FOF52_RS15595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_15490"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_248590673.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 4.2e-15, bitscore:
                     53.4, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTSLAGGSTALADPPGIDDEFALDVKVVLATHPNGKLQCSTSDG
                     CGSTCNDGASACNSSIEPPLS"
     misc_feature    complement(23583..23598)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 21.84"
                     /tool="antismash"
     misc_feature    complement(23584..23593)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.42"
                     /tool="antismash"
     gene            23983..24588
                     /locus_tag="FOF52_RS15600"
                     /old_locus_tag="FOF52_15500"
     CDS             23983..24588
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF037009.4"
                     /locus_tag="FOF52_RS15600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_15500"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_248590674.1"
                     /transl_table=11
                     /translation="MTTDADRLPGTAAAVPVPGRRGRRNDPGRRDRIIDACLDVIVEQG
                     VAGASHRKIAAAAGVPLGSMTYHFTGMDELLREAFRRFALGVSARFERRMLDARDAEEA
                     KAAVVALITADLLSSRRDLVLTSELYTLAARKPEFRDLTNRWMARSRAALERHFDPVTA
                     RLLDALIEGLTLHRGLDTEPHDTAAVVEAVDRITRCGN"
     misc_feature    complement(24695..24709)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 23.4"
                     /tool="antismash"
ORIGIN
        1 cgctccccgc tcccccgccg gaagaggccg cacccgactc cgacaccgtc cgctccgtcc
       61 tgcgcagccg cgccttcgtc gccctgaccg gcgcactggc cctggccgcc ttcggcgcct
      121 acgcggtccc gatgaacctg gtgccgctgc tggccgagcg cggccaggac acgggcgtcg
      181 cggcgtgggt gctgagcgtc ggcggactcg gccaactgct cggccggatc gcctacggcc
      241 cgctgcaccg gcgcaccggc gtccgcacct gctcggtcgc cgtcctcgcg ctctgcgcgt
      301 ccaccgttct gctgttcgcc gcggtccccg gcccggccgc ggcgctgttc gccgtctccg
      361 cgctggcggg cgccggacgc ggactgttca tcctgttcca ggccaccgcc gtcagcgacc
      421 ggtggggaac cgcccgctac gggaccctca gcggtgtcct gcacaccccg gcgaccatcg
      481 ccatcgccct gggccccggg gcgggcacgc tgctcgccga cctcctcggc agctatccgg
      541 cactcttcgt cctgctcgcg gcggtcacgg cgaccggaac cgtcctggcg gcgtggtcgc
      601 tcccctcccg ccgctgacgg cgccgccgcg gccccgccca ccggccccgg cgtcccccgt
      661 gccgtcgcgg accggtgccg agcgtcaggg gtccgcccgc agtgccgcgg tgatctcggc
      721 gaccgcgttc ctggcggccc ggcccgcgcc gatgatcgtg gccgacgccg gaccggtcca
      781 gtcgccgtag cccaccaggt gcagccgcgg ttcggccgtg ctgcgggtcc cctccgtggc
      841 gatccgcccg tgcgggccgc gcagccccag cggcgccagg tggtccagca ccgggcggaa
      901 cccggtgcac cacagcacgg cgtcgaagtc gtgggcggtt ccgtccggcc acaccgcccc
      961 gcgctcggtc agccgcgcga acaccggttc ggccttcagc acgccccgct cgcgcgcctc
     1021 ccgcaccggg ggcaccacca cgatgccacc gggctgctcc cccgtcccgc cgtcgccgtc
     1081 cgctcccgcg gcgcgggccc gcaactgccg ggtggcggcg tcgaacagca cccgtccgtc
     1141 cacgtcgtcg gggaggaagc ggggcggacg cagcgtcgcc cacacggtgt cggcgaccag
     1201 cgacagctcg gcgaggatct gcgccgccga gttgccgccg cccacgacga gcacccgctg
     1261 ccccgcgaac gggtcgggac gccggtagtc gaccgtgtgc cactgccttc cggcgaagac
     1321 gtcgcggccc ggatagtgcg ggacgtacgg ggcacgccag gtcccggtgg cgctcaccac
     1381 ggcacgcgcc cgccacgtcc ccgcgtcgga ctccacggcc agccgccgcc cggcgcggcg
     1441 caccgccgtc acccgcaccg ggcggcgcac cggcagcgcg tagcgcttct cgtaggcggt
     1501 gaggtagcgc accacgtggt cggcggtcgg atactcctcc ccctcctgct ccggcatcca
     1561 ccagccgggc agcgggctgt gctcggcggc cgagaacagc cgcagcgaat cccagtagtg
     1621 ctgccaggac ccgccggggc ggtgctcggc gtcgaggatg acgtgggtga ggccggagcg
     1681 gcgcaggaag tacccggcgg ccaggcccgc ctggccgccg ccgaccacga cgacgtcgta
     1741 ctccccgggc tccggcgtca gcacggccga cgggagccgc gcgtccggcc gggggcgcgg
     1801 cggccccgcg gcccgggctc caacggcgtc gtcgggtggc acaggccggt ccgccccggg
     1861 gcacgcagcg ggccgccgga cagctcgacc acggcttcgt cgccgcctcg accagcggag
     1921 atcaccattc ttcgatatga ccatcccgcc gcgaggccgt caaacccctg ggccgcggcc
     1981 cggccgggtc cgcgtccggc cgcacccgcg tccacaggtc ggcccactgc cgcgcggtga
     2041 ggtccctggg cagcgcgtgc ggggacaccc ggtgggcgcg cagccagccg cgcagcacgg
     2101 gacggggaac ctgcccggtc cggaggagga tctcgccgag gccgcggccc ggcccggtga
     2161 acacccggga cacgaaccgc tggtacccct tccggtcagc gaccaggggc tcgggtctgc
     2221 gggtggcggt gagcaggccg ccgtcgaccg aggggaccgg ccggaacgcg cgggcgggaa
     2281 tccgcgcgtg gacggcgaac tcgtaccagg gccaccagga ggcggtcagc agcgtcgcgc
     2341 cgccgacccc ggcccggcgg cgcgcgacct cccactgcac caccaggacc gcggtgcgcc
     2401 agtgcggcgc cgcgagcagg cgccgcagcg cggccgtggt gaggtggaac gggaggttgc
     2461 cgacgacgac gtgcgggacg ttcggcagcc ggaaccgcag caggtcgtcg ttgacgacgg
     2521 tgacgttccc ggtgacgcgc cgccgcagcc gccgggcgcg ccgggggtcg agttcgacgg
     2581 ccgtgacggg gcggcccagc cggcccaggg ggacggtgag ggcgccgtcg cccgcggcga
     2641 gctcgacgat cggcccgcgg gtcgcggcga cgaggcgttg gatgtcggcg atgaccgccc
     2701 ggtcggtgag gaagttctga ccgagttcgt ggcgtccgcc gtgacgggaa ggagaggaca
     2761 tgggtgtggc tccgcgtggc aggtggagcc gggcagcgtg aggcgccgca ccggcgtggg
     2821 acccggatgc tgcgaatgca cccatgcgag gcatcgtaac aggaccccgg ggcggcggca
     2881 cctcgttttt ccgccgcccg gaccgcgtgg tcagccgccg tgcggcggct gcgggtactg
     2941 cgggtggggg ccgccgtacg ggtgcggcgg gtgcgggggg aaggccgggg gctgcggcgg
     3001 gtagagggcg tggagttgct tctcgtcgat gaccacggtc ttgacgagtt tgtcgtgcag
     3061 gcactgccgc cccggccggt cccacagcat ccacagcacg ttgagctggg cgagcacggg
     3121 aaaccagctg atcggatagt agatgctcgg ggagtagcac agcgcccgca gcgcggcccg
     3181 cccggagggg aggcggcctc cgtcggcggc gtcgacgatc cgcaggccca gcaggcgctt
     3241 gccgacggtc tggccggccg cgcggaccat cagccactcg tagcagaacc ccgaaccgac
     3301 cagcgccccc accaggatgg gcgcctgcca caggggcgcg ttgtccatgt cgccgccgtt
     3361 gagcagcagg aggccggcgg tcgccgccag tccggccacg atgttgcaga agaacgccac
     3421 gaatccgtcg atgatgcggg cgagcaggcg catgaagggg tcggcgagcg gcagcaccgg
     3481 cggatgcccc ggcgcggggg acggcacctg gtagagccgg tccgggggcg tctgcgccgc
     3541 cacgacccgg gggtgggccg ccgcgggcgg tcccggcggg tggggggccg gaggcggcgg
     3601 ggtgaactgc ggtacgccgt ccccgggcgg gggcggcggt gtgggctgtt ggggatgcac
     3661 gggtttcttt ccctgtgttc tcggggtgag gggcggtccg ccgttcacgg ggtgcggcgg
     3721 cgcgggcggc cgactcgaaa ccgcggtggt cgtccccggc cggtggcgcc cccggggcgg
     3781 acccgggcgt cgcggcggtg ccgggcgtga ccgggaccgc cgcggtgttc ggcgccccgc
     3841 ccggacagtg ggcggtgtcc tctccggacc gtccccgcgc cgtcttcgcg ggagccggcg
     3901 cgggagtcgg cgcgctcccc accgtaacgt tcacgattcc ggcgtccaac gccgctgacc
     3961 gcatgcggcc aggtgggacc gcgtggcgcc gccgtgccct gaccttcctc ttcggaaggc
     4021 acaaccccgg tcttacgccc ccggatgccg catccggccc gaaaacccgt tacgcttaag
     4081 ggacgtgtat ggcaccctgg gcggtgcggc acgcgggcca ttagctcaac tggcagagca
     4141 gcggactttt aatccgcggg ttcagggttc gatcccctgg tggcccacca caaaacccca
     4201 ggtcagagcc ggtttcgtcg gctccgcggc ctggggtttc gcgctgtgtc ggctccgtgt
     4261 cggctcttaa gttcgcacct ccaacgtccg cgcgggccga ccccttactc gcgggttctc
     4321 cacgtcatcg gaggcaaccg gcagcggcca tccatgtgcc ctgttctgcc gcgatcaggt
     4381 aggggcggac gagtggtccg gggtcgtcgt cttcgacgcc cgcggatcgg cggggggtgg
     4441 gaaccgcggc cggttcggtt ccgcggtggc gtccccggta gggctgtctg ttcggcccgg
     4501 ggccgggagc agggttttgg tggtcgcgct gggcggccca ctggcggatc agtgcggcga
     4561 gttggtggtc tgccgggtcc tggcccggct tctcgaccgg tcgctggatg ggcggggcgc
     4621 cctcgaccgt cgcggaagga acgcggccgc gcgggactcg caccggcgtg ggctgtcgga
     4681 tttcggctgc gatgtccgct gcccgggtcc tggctcttgg gcggggctgc tgggtcgcgg
     4741 cgggttcgtt gacgaagagg tgtcgcagga gtgcgcccag ccactggcag gcccgccaga
     4801 acggacctgg cggtttcggt ttccgatgcc gggcagcacc gatacgctgt gccatgtcac
     4861 cacctgtgct ctcaggtcgg aggccgtgcc ccggaggcgg ttgctgcgcc tgccggggtc
     4921 ttggtttttc tcgggtcggg ggttcagcgg ccgccgtgcg ccgtctcggc gcaggcgtgg
     4981 tcgaaggctg cggccaggtg ctcggcgatg gcctccagtt gttcgctggt actggtgagc
     5041 ggcggggtca ggcgcaggcc cgtctgcccg tgggtaaggc ccaggagcag gtcgcggtcg
     5101 cggccgccgc gaccaccgcc tcgaccgggg gtgcgggggc ggtgtcggtg gccagcggta
     5161 ccacctgcag gtccaagccg tagcgggtgg tgtggatgcg gtcggccagg cggcgttcga
     5221 tctggtcggc gaggaaggcc ccggccttgg cggcctgcgc gctcagcgcg tggccggtga
     5281 ggtggtgcag gacctcggcg gccacgctcg cggcgaaagg atgcggatcc tggtcgggac
     5341 agtggtcggc cgcgtgctcg acggcggcgg ccaggcgcgg ggcggccagg aggacgccgc
     5401 aggcgccgta gccggccacc aggctgtcgc ccaaagccgc cgcgtcgggg cgcgcatcag
     5461 cgggcaggcc gcccagcagg gtcagcgccc cggaacgccc cagacccaca ggggtctcgt
     5521 cccaggccag gacaagaccg tactcgtcgc acagtccccg cagctttcgc atcgtctcga
     5581 cctcgggcgg cacggcggtc agcaggcgca ccacgattcc ttggaccggt gtgccggtgg
     5641 cgtgtgcgcg gtcgatggcc cagcgcaccc gctccaccag atctcctgtg gtgaccgggg
     5701 ccggcacggc ggatgcgtcc cggctgctgc ttccggtgag gcggaggcgg gccgggccgt
     5761 ggtcgaacac gacgtgcacg agtgcaccgc tttgcccgcc ggggccggtg gcggcgatgc
     5821 gggccaggct gtcggccgcc cgcgtcccgg aggccaccag gaccgcgtgc gccatcccgg
     5881 tcacggcgtg caggtccgca accagcagca gttcggccag ggccgtgtac ccctcgggca
     5941 gcagcggcag ccgggcggta cgggccagag cacgcagcgg atcccagcca tagcccaaaa
     6001 tcacccggtc accggcggcg gtggcatcca gcagccaccg cccgtccacg gtgcacacac
     6061 aggccccgtc cccaccagca gccacccgcc gctgctcggc ggggcgtgtc ttcagggtca
     6121 tggccgactc cccaaaccga cggcagtggc aggagagaca gcccatgtga cgggagggca
     6181 gtccaaactt ttgaggaggc tctcgacctg ctgtggggcc agcacggcgc tgtccaggat
     6241 gggcagcatg aaccacacgc ctttctctcc cggtgctatc aggcagccca gtcgcccttg
     6301 gctgatcgcc gcgacggtgg agagcccgcg tcggtgttcg atctccggtg cgtcgaaagg
     6361 cagagcgtcg atgtcgtcca ggcccaactc aagcggagag gcggcgtgga gttggatgtc
     6421 gacaggactg ggaagcccat cggtgacaca cacggtgatg ctctttcccg ttgttccgtg
     6481 gaggcggagc cggtgaggtc gtgtggcgtg gcggatggcg ttgccgacga gttcggaact
     6541 ggcccagccc gcgttgtggg cggtgtccgc gtcgagtccc agcttccgca tgacgccttc
     6601 aacgaaggcg tatgcaatct gctgcgccct tgaaagaccg gtgaggtcca cctcaaccca
     6661 gggaggaggg agccaccagt cagtcatcgg gctgtgctcg gaactgctca gcgactcggg
     6721 gatgcgggcc cggtgtgaca tcagctcacc cactcgggaa gaggcacctc aaaagacggc
     6781 gcaacaagga actcgttcac ttagaatctt gaactaggaa gttcatagtt ttcaagtcac
     6841 tgttcaatgt ttccgatatg tcccgttcgg agcttggtgt gaagatctat gatcgacaca
     6901 gaagcaaggg aggctggtgt ggcgaggcaa ccggtgatgc caaccgtggg caaacggcaa
     6961 ctcgggcgtg aactccggtc actgcgtgag gcgtcgaagt tcaccctcga ccgggtcgcg
     7021 gaggagttgg actgggccaa gaccaaggtg cacaacctgg agaacggcca ctggacccgc
     7081 ggcaacctca cagacctgcg cgccctgctc gacctctacg gcgtcaccga cccgcagcgg
     7141 cgcaccgccc tggaagacct catgcgcaac gccaagaagc ggggctggtg ggtggagtac
     7201 ggcgacgcgc tcgatggtgc actgcccgca ttcgaagacg aggcctccca gatcagcagc
     7261 tatgagcccg ccgtcattcc cggcctggtg cagacacccg agtacaccgc cgcgctactg
     7321 cgcacctacc cgttcctcac tgccggcgag gtcgagcgca gggtggaggc gcggatgcag
     7381 cgccagcgga tcctcgaccg cgacaccccg cccgaagtct cgttcgttat cgaggaagcc
     7441 gtggtgcagc gcctggtcga cacaccggtc gcccgagctc agatccagca cctgatcgac
     7501 gtggccgagg cagccaaccg cgtcaccctc caggtcatgc cactgcggtc gggcctgcac
     7561 ggtgcgctgg gaccgtcgtt caccctcctc gacttcgcag gcgacttcga tctctcgatc
     7621 gtctacaccg agtcagcggc acgcagcgcc taccttgaag acaaagcaga cgtagccctg
     7681 taccgcacca tgttcaccca cgcctgcggc agggcgcttc cgccggagaa atccatcgag
     7741 ctactgagcg gcctgctcag acagtcttcc tagagagccg acttccatgg acctcttccc
     7801 caccgactac gaacccctgt tccgtaagtc caactactcc accgccgccg ccaactgcgt
     7861 cgagatcgcc gaccttcccg acggtcaaca cgctgttcgc gacagccaga accgccacct
     7921 cggcggcttc ctgttcccca cgcaagcatg gggagcgttc ctcgcaagcg taaagaccgg
     7981 cgagttcgac gcctgaccgc cctaccggag aagggacctg acgcagactg cgcaggtccc
     8041 ccgaccagat cgaaggccgg gtcaccgtgc ggatgcggcg acagcagcgg ctcaccgacg
     8101 accctccgct cgccttcaac gtggtggtca acgaagccgc gctgcaccgc agcgtcggcg
     8161 gcaccgacgt gatgcgcgaa caactcaagt tcctgctgga acggatggag cttcccaacg
     8221 tcgacgcacg catcctgccg ttcgaatccg gagcgcacac ggccagcgag ggctccttcg
     8281 tcatcatgaa gttccccagc ctgctggaga acgtcacctt cggagatgtc gtgctgatcg
     8341 agtaccgggt cggcgcgctc tacctcgaag cagaacagga gacccagccc ttctccagag
     8401 tcttcgaacg gctgcaggca accgcgctgg acccccgcga gtcggccaag cgcatccaac
     8461 acctgctgaa cagcagatac ggaagataag gaacagacaa gtgacgctcg acggctcccc
     8521 gctcatctgg cgcaagtcct cctactccgg aggtgccggc ggcaactgcg tcgaggcggc
     8581 tcgcctgccc tccggcggca tggcgctgcg cgactccaaa caccccgaag acgcggtcct
     8641 gcacttcacc cgcgacgcat ggacagcctt ccggaaagcc ctgtgcgacg gcggactctt
     8701 ctgagaccgc cgaggccgca ttcgctcagg gctcacgggg tttcttgcag cccgtattcc
     8761 ggcattcccg ccccgggaca cacgaggccg gactcggtca ggaggcctgc ccttcgtcca
     8821 gggaagccaa cgttcccctt ctcaacggct gactatgcgt gtgatggtct cttcggcact
     8881 ggtcagtgcg gttgtgaggt cgtccagcaa agctgcgggc agtgtgccgc ggccgagcgc
     8941 gcacgtgtcg accagggcgt tcagttcctg cgcttgggcg gaggtcagga gattgcggca
     9001 accgccgtgg tcgagtaggt cgcgggcggc gtatccgtcc tgtgaagcag cggtgcggcg
     9061 gatgaggccg gcggcgatcc ggtatgcatg gggattgtcg gcagtgccga gggcatcgat
     9121 gaaggacagg cccagccggg tgtggaagac cgccaggccc ggcgccgagg tgtcgagcat
     9181 gtagtacagg tccagcaagg gccccagacc cgcgtcgtct gaaccgctgc gtcgacaccg
     9241 gatggtgagg caggcggtca cggcgttctc ccagggctct cctggctcgg tgtcttccag
     9301 aagagcgagg gccccgtcgc cgtctccgga tgcggcgtga gcgatgacgg cgacctggcg
     9361 gccgtcgagc atgcggcggc cgatgccccg gtggtcacgc aggcgtttgt aggcctcctg
     9421 ccagagtccg gccgtggcga gtgctctgga agtggtggcc agcatgaccg cccacagcca
     9481 acggcgtact tgctggtgcg cctctcgcga gtcggtgagg cgagcgggga gctcgacgct
     9541 gtcgacagtg gcgctggcgc aggaggagac cgcggtgtag agggtgtcga tgaggtcgga
     9601 agcgcacccg ccccggccgt cacggatgtg gaggcgggcg aggttgatca gtggttcgag
     9661 ggcatgacgt gccgcttggg cccccagagg gtgagcgcgg aggtagacgt tcgcgtgccg
     9721 atgacaccac tgccgggcca gatctggcag accgcagtcc gaagcgagga gcgctgccag
     9781 gttgtgtacg gctgaggcag cggccaagtc gctgtcccgt tcggctgcgc gggcccggtc
     9841 gcacaggtcc gccacgcgct gggcaagagg agtgcagacc gggcgagggc gagcgacgag
     9901 cgggaaacgg gaagcgaaca gctcaatggg gtgtacttct tcacgtctct ggtgcctgct
     9961 gtccggggtg gcactgtgtg cgggggccgc cgtggtggcg tcacttcctg tcaccgcggg
    10021 ctcctggaag tctcagcggc gtcatagtgg taggccattc gtcacgatcc aggactactg
    10081 tcttggcggt gtgggcgatc aggctttgca cggtgtatgg caggccgagc cggttccagt
    10141 ggaagatgat ctggtgagcg aggacggctc gtaatccgcg ggtgagtaga ccgtttcgag
    10201 caaggccacc tagtctctga ccggcttcag cgaaagcgac agcccattcg gtcagaaaag
    10261 ccagcggtcc gttctcgcgc aggagagggc ttgtggggcc tgcgtccacg gtcatcagcc
    10321 gccgtaagtc ggcttccaac ctgttcatcc gctccgcagg gatgtcggga ggatccggac
    10381 ggattccggc gacgcgtgcc cagacgtctc cttgttcgta ccagtcctgt cctgccccgc
    10441 gcatcagcat gctgcacagc agaacagaca gttcgcgccg ctggtcgccg tggccggtgg
    10501 gcgggacgtc ctgacggccg aggtaggcga ggacgtgtcg gctgtcgacg tggaagagac
    10561 ggtgggtcaa ctccatgccc aacggaccgc cgaaggcgtg tatctccggc tcgtagatgg
    10621 ttggggccca gccggcgatg tgaccgccgt ctcgcaacgc gtcgagtctt tcgtggagga
    10681 aaaccactgt ttcctggccg gtgccgtgtg ctaccaggaa acgaatccgc cagcaggggg
    10741 cctttctgac gaagaaccat gccctggtcc ttccagcggt ctctgcgccg gtcattatcg
    10801 gaccgatgtg gacggcaccg acgtgttcgg ccacggagta gtcggcgaag ttgacggtca
    10861 cctggtgcca cagggcgtct tcccgtaccc tttcgggggc gtggttcatg cgctcagggg
    10921 tcctttcatc cggttcccga tcagatgaga agcagacagg cgtcccaacg gctgattggg
    10981 gcggtaccgg ttccagcggt gtgcagggcg agcgccacgc ctgcgtgccc gtcgaggaat
    11041 tcgacatctt cgggcaggga tgggagctgg gaaagcagtc gcgccgcaag cctgggcagc
    11101 tcctgtgcga tgtccggtgt gctggcgtca tccgccatcc gccacgcggc ctggagcagt
    11161 ccagccgtgc cgtggcacaa gccggcgtct gggagcaggt tgagctgcgc ggggtcgcgg
    11221 aggcagccga gcatagcggc ctcggctgtg cgttgccgtt cgaggtcacc agtggccaag
    11281 cccgcaagtt gctgggctct ggcgagcccg ggtgttccgt agcaccacga cggacgttgg
    11341 cggctggatg cctctacgtg ctttcgacgg gcctgttcac gggtgacgaa tcccggccac
    11401 cacgggccgc aggggtgttc ctgctgccat acgtccaacc aggcgcagat acgaccgatg
    11461 gcctcggtgt gcccttcgac tgtgattcct ttcagcgcag ccagtgacag cagtgccagc
    11521 ggggccgcga tgccgtgtga catgccgagg ttgccgtggc ctccgggaaa gtccggtgca
    11581 ggatcaccgt tgagggagac gtcggtccac catcccggta ggtcgtcggc gtgctccgga
    11641 agcggttcag tcaacctgac gaggtaggcc agcacggcct gtgtgatctc atgatcgggg
    11701 tggcgtagca ggtggtagac gccgagaccg gtcaggccgc gaaccagatc gaactcggcc
    11761 atacggggcc ggattccctg gtcgatgcgg gtgtgggctt ggctgaggcg atgacgggtc
    11821 atggccgtga tggcggtgtc gagttgggtg agagcatgcc tgtacctgct ggaccggcct
    11881 gcggcggcac ggatcacgaa cgccaaggcg ggaactccga agtacagtcc ggcgttggga
    11941 ccagcgctca actcctcgtg cacggcagcg gacagccatg tgtgcacggt cgtccagtca
    12001 ccatggccgg tataggcgcg ttcaatgtgc aacagggcga ttcccgccgc tcccccggcc
    12061 agtgactggg gacgccgacg tcctctcccc cctgaagcga cgccacgact accgattacg
    12121 gacggatcga ccaggcgtga ggcaacagcg ctggccgcgg ccagcgcttc cgaacaaggg
    12181 ctgttcatag ggctccttgg gttcgcgctg tccagctcag ggcggcggcg cgggacagac
    12241 gacggcaggc ccactccgag tccggggaaa tgcccaccat gcgggcatgg tgcaggtgca
    12301 gaaggtctgc aagcaccgtg tccggggaaa tctgcttctc ggcggtgagt gccgcgcggt
    12361 accggagaag cgccgcgcgc cgcagttccc acgacgccgc gatgtcttca ccacctggca
    12421 cctccagaag cgcggaccgt ccgcgactcg ggtctgccag gcggatcatc tggtcgcgtg
    12481 tttcgcgaga cggtgcggga gctgaagatg cgcgccagtg acgaatcagc cagcgcattc
    12541 cgtcactgac gctgcctgcg accgtgacgg cgatgtcgac catgctggcg gcagtgacgg
    12601 cgtgcagatg cgggccctca cggtggtcga ccgctcgcag ttgcgcgact gctgcggcag
    12661 aatcggcggc aaacaccgac tctgctgcag ccatggccac gtcctgtccg aagcgcccgg
    12721 tctccggata gtaggtgtcg aactgcacct ggctcacgag gccacgctcg tacagctcag
    12781 tcgtccacgc ggtgacccga gcagcgacct gcccgaagtc gtcggcttcc cgaagtcgga
    12841 tacgcaagcg cagatgcttg tccggatcgt ggtagcggag aaaccaccac tcgggttcct
    12901 tttcccacgc ggccagcagg gctggcagat gcgaggtcaa aagagcggtc tgccggccgg
    12961 ggttcccgta cagcttgacg tagagccact cactgcttcc gggaaggtgc ccgtgggcac
    13021 ggctgagcac gcacctcgac caggttcgct gcggtgcagc gggtggagct gtggcggcta
    13081 gggggatgac gatgtcgtga gcgcgtccgt cgatccaccc catctcatct tcttccggtg
    13141 cctcgcgtat ggttgcgtgt ccgttgcgcg ccaggtcggc ccggagcaca gcaagatggg
    13201 cggactcgtc caagtccagg cggattcggc gatcaccgtc gccgagatag accgaggcgg
    13261 gcacacgaaa ctggtcccgc cacgcgtccc acctgtcctt ccagttccgc catggttcgg
    13321 cagaaccggg aaagtctgtc gcagtcagcg tccacatagc cggagacaga atcgaacgcc
    13381 ggtagcggat tctgggcagg aacggcaacc tgctggccgc tccccaggaa aacggaacgc
    13441 acgctgccgt acgagccgta gagatctcgc agaggaaccg caggagcggt tgagcgtggt
    13501 gggtgagttc cacagcgctg aacaggatcg gctccaccgg ctgtcggcgg gacacagaga
    13561 ccaggtagag ccgctgggca tcagcggtca ccgcgaggtc gtccaacgag acggcttcct
    13621 tgccgtccgg gcactgttcg gccaagggga ccaggagagg cagcacagcg ggacttcttg
    13681 tgatgttctc ggcccgccgg gacaccgttg ggccggacac ctgcacccgc agtgcgttct
    13741 gacagactgc gggtagttcg gcgtaggccc ggaacattcg ttcctggtca cccgtgtcga
    13801 acaggtcgag aaaccgcccg gccgtggtgc cagccgcgcg ggacattccg gtgaccgcaa
    13861 gtcggaactc gcctcgaccg agcgcaccgg tactgggcga gtagatgcgg caccggagtt
    13921 cggtatgcgg ctgcacccgg tactcgccaa ggctggcagc cgcaaggttg tcgaccagtg
    13981 cgtcgtcgat gacgacttcg gtgtgctgct gcaccgcggc gttctgcgcc aagacgagca
    14041 gggccatgtc gcgtttggac aggccgggaa cgctcggagg agccagacgt gaattccggt
    14101 aaccgtgggg gaaaccgaga ccgctgtcgg catcgagcag ttcccggatg ccgaccaggg
    14161 agccgagtcc gtaccgttcg cagaaccttc ggtggtagtc ctgccaggcc ggagttccgt
    14221 gggggtgcgg tcccagcctg gccagcgcct ccgccgtacg ctcggcttcc cgcaccaccg
    14281 catgcggcag gaccaagtca ccgtcgagcc gaagatccac cgcgatcggc cgctctgcgg
    14341 tacagagggc agccattctc cgggagacat gcgatcgaag actgcgtccc cgcagaggag
    14401 gggtcgcgtt gtggtggagc agatcggcgt ggatcccgca caactcgtcc agcagacctg
    14461 ccgccccctg caccgtgtcg gcttgtaccg cggtcagcgc ttcaatgacg tggcccagcg
    14521 ggtcggtgac cgtcatcggt ggacgcagac tggtgaccag gagacgatgt tccaccagcc
    14581 tggtcagcat ttcgttgatc acagagtccg gcttgtccgg aaagttggat gccagtttgt
    14641 cggccaggtc ccccagacga accggggtct gagcagcctg aaaaacggtg tgaaccgctt
    14701 cggtgtagcg gaccgatact tctgcgggcc cggttccgtg caccgctccg ctctgccaac
    14761 atcccaccac cagccgtccg tcccgaacga acgcaaggtt gttgcgcacg accagtagtc
    14821 ggtacctcaa ctcggggatg gcttccagac gcgtgatcac tccgtcgagc caggtggagt
    14881 cgacccgcgc gacggcgcga tgccctccac cgaaccgcac cgcaggtgtg tgaccgagcc
    14941 ggacaggtgc caccccggag aacagaccga acggtgtcgc ccggcttgtc gaccgtaaca
    15001 ggtaccgaat cagcgacagc accgctcggc ggacctcttg cctccgcact cggctcccct
    15061 gacacacctc ttggactcga cgagccaggt ctgggctggc gatctcgaca ctcgccgcga
    15121 acccgtcgga tgcccacacc tgccgcagcc agtccaccca ggacgtcagg tttttctccg
    15181 cgtcatcggt caggtccggc cacggtggca cgcttccggg gcaacgggct gctgctcgca
    15241 ccacggccgc gtccacgaac ctgtacaaat ccactcctca gggttgggta ctcgcggggt
    15301 ggcgtccgcc accccgcggc gtatgggagt cgaggctgga ggggtcagca accgctctgg
    15361 gccgggcagg cactctcgca ggtggtcccg cacccgtcgt cggtgagccg catcaggtcg
    15421 ttgatgacgg gaccggactc gacgatgctg atgtcgaggt cgaactgggt gttttcccca
    15481 tcgatcgcgg tctgaggggt ctggacggtc atgcattcct cctcgtagtg acgttgcccg
    15541 aaatgttcca gggcttccgg cccggcttcc ctgcggtcag ggccaggaga cgacgatgcg
    15601 ggtgtgcttc ttgtcgacga cccttccggc gggaagtgcg gcatcggggg tggctgcggg
    15661 aaacacctcg atgcgcgctc ccggtccccc gcggtggtcg cggtcccagg tccggatgtg
    15721 gtcgatgtac tcctcggcga ggcgttcgga gtcggggccg tgtgcgtagg cgccgaactc
    15781 gaacctggtg cggctctcgt cgaccggacg tgccgaggcc cggtagacga aactgctccc
    15841 cgacacgatc gctttgccgc cgtacagcgc agacctgctg gtcagcccgc tgtcgaccgc
    15901 ctctttcgtg gctttgacca agccgaagcc gtcggccacg gtggcgatcc acaggtccag
    15961 gtcgtggagt ggctcgctgt cgccgaactc catgcctccc cagcgctcgg tccgcggtcc
    16021 gagcagggcc ttgcgcaggc cgtcggtgtc aacgggccgg tcggtgtcga tcagcaggct
    16081 gaccctgtcc tcgtccaacg tgaccacctg ctcgctgtgg gcctcggctc cctgcatcgg
    16141 cacgaaggag cagagctggt agtcccggct caccaggcgc tcacctgcac gctcgaaggc
    16201 caccgagcgc gtcagcccgc gcagccgcag cggaacgacg agccttccgt cctcggtgag
    16261 ctgctcgatc catgcgggtg ggatgtccca tgcgcccgcg gtgacgatga tccggtcgaa
    16321 cggggcgtgt tctggaacac cgtgggcggc gtcgcccagc gccacgtcga cccacccgta
    16381 tccggtggcg tcgaggtagc gtcgggctcg gccggtgatc tccggatcga tgtcgacgga
    16441 gaccactctc ccggtccgac cgaccagttc ggcgatcagt gccgcgttgt agccgccgga
    16501 accgatctcc agtacccgca tgcccggttc gatccgggcc tgctccagca tcacggcctg
    16561 gatctccgac gcggacacca cgctggtggc cgtccccgca ccgtcctgct tccggtgcag
    16621 cgtggtcatg gtggcgtagg cccgctccag cggctcgccc ggggcgaaca ggtgccgcgg
    16681 caccacgctg aaagcagcag cgaccggatc gctgcggacc gctcccagat cacgcagttc
    16741 acccaccatc ttctcgcgca ggtactcagc gcggtcggtc tcgccggtgc tgctggtctt
    16801 cgtatcttga tgttctctca ttcggtggtc ttccgcgttc tggggccggc gggagaagtc
    16861 caccggctgg aggtgcacgg ggaatccggt cttcgtgaaa ttgggttccc tctcctcgtc
    16921 ttcaccgaag tggtacgcgg agaggtgacg tgaaaacgag tttctgggca cggggcatgg
    16981 aggtccatgc cgagctgtca taaatttcgg cgtacttctt cacaccacca agaaagagcc
    17041 gcttttcaca ccatttgacc agtttgccgc ttttctggcc tcaagggttc cctgtgaaga
    17101 cggaagaacc tatgtggaga aaccttcgac agaattgaga ggatctggca ggcggctcca
    17161 tcatcgtggc aggccacgcc agccccgaag gccctccggt ggtgccttcc cggtagcgat
    17221 ctgaccctca ggcatcagcg ctgtagaaag cctgggcaag gacatgagtg gtcgaaggcc
    17281 ctgccaggac acttgcccgg cgctcgaaac accgagcgac ggaactccgg gcaggccgga
    17341 agtagaagtc ggacatcaca gccacggctt caccccgctc tcacggcagg gccacgccgt
    17401 gaccgtccgg tgcccttggc ggacagacga ctcgacgacc atccttggac agccgatccg
    17461 cagagccttc cccctgggag ccctttggtc ttctggcgct gttcacccct ggcgggtccg
    17521 ggtgacaagt tggagggaag gagttgctcg cagcggaaca actgttggct ttgagcgcac
    17581 aagcggcagc gatgattctg acgaagctcg gagaaaccga cctggcttgg atcgcggcgg
    17641 agcgtggact ccaggcagcg caacgatccg gggatactgc cgtcataggt tcgctgttga
    17701 ggtcaggcgt gcattcgctc cactcttatg ggcagggcgc aacctccgtg gagatggccg
    17761 agcaggccgc tgcttacctt cgaggagaaa tggactggtc atctcctaaa gaactctccg
    17821 tgtacggaac tcttctgctg cccggagccg ttgccgccgc acgcgaagga gaccgacgcg
    17881 cggcccgtga ctacctggaa gagtccgaga aggtggcttt gcgtctgggg atagatcgaa
    17941 acgacctgtg gacgtctttc gggccgacaa acgtcgctgt ccaccgtgta gtggtggcta
    18001 actccctcgg tgacgtggac gccgctatcc aactcggtcg aagaatcgat ccttcagggc
    18061 tccccattga acgacaggtg cggcacgcgc tggagttggc ttcagcctac gttaagcgca
    18121 accagatcga tgcggcggta ggccaggtac tcgaagcaga aaagctgtcc cccgaacaga
    18181 ctcggcgaca cgtgatgagc cgtcagatag tcacagcgat gctgcagacc aagtccggaa
    18241 agcgaaaccg cgacctggtg tcgctggcca tacggatgaa agctctctga ctgtgccgtt
    18301 aaggtcttcg tatgagcgtt gatcccgcag agtcctttgc tcggccccgg gtggctgccg
    18361 gggtgttgtt cttcgacgag caggaccgag tgctgttggt ggtgccctcc tacaagcact
    18421 accgcgatat ccccggcggc tacgtcgaac acggcgagac tccccgtcag gcggcgcagc
    18481 gcgaagtccg cgaagagttg ggcatcaccc cacccctggg cagactactg gtcgtcgact
    18541 gggcccccac ccccaccgaa ggcgacaagc agctcttcgt cttcgacggc ggcccgctgg
    18601 agcaggagta cctggatgcg atcgccctcg atccggccga gctgaccagc tacgagttct
    18661 gcgacgccac ccgaatccac gaacacacca tcccccgact ggcccgcaga atcacccagg
    18721 ccatccaggc ccgcgtcgag aacaccaccc gctacctgga aaacggtgca ccggtcggat
    18781 agccatcagc gaaagtacca aaggcaatcc cggtggagcc tgatgcggcc gacaccgggc
    18841 agaacatcgc cttctcccgg cgggtgctgg ccggggcggg cctccgcccg gcctcggtga
    18901 tgctggcgac catgccctcc atgcagcggc gcggctacgc caccacccgc aaggtctggc
    18961 ccgaggtgga ggtggtgtgc gcctgtgagc cggtggcctt ccgcgactcc ctggtgggca
    19021 tcggcgacga ccggctcgtc atcgacacca tggtcggcga cccgcaacgg atcatcgaat
    19081 accccgaccg cagcttcgcc gtcgaacagc acgtgcccga cgacgtccac accgcctacc
    19141 aggcgctcgt caaagccgga tgcaccagcc gcctcatcgg agcctgaccc ggtacacaga
    19201 ccagcgaccc tcgagtccag atcgtctcca cagtggggga gaacacggtg tctacactgc
    19261 cgggcatggc cgatcagcgt gtctgctccc tcgtcgtctc cggctcctcg gctcccgagg
    19321 gcgttcccga attggtggaa ctcttccagg aagacgggtg gcggatcacc gtgctgtcca
    19381 cacccgccgg aacccgcttc catgacctgg accggctggc ggagctgacc ggggaaccgg
    19441 tgcgggtgga cttccgcagg cccggtaccg gaaagagcct tccccctgcc gacgtggtgc
    19501 tggcgtgccc gctgaccttc aactcgacca acaagttcgc ccgccgactg ctggcattgc
    19561 tgcccgcagg cagccagacg tggctgctgg cggacctcta ccccaccgcg accgcccgtg
    19621 gacgaagtcc tccttctcca ccaccggaga gggatgcgtc caggtacgcg ccaccggcaa
    19681 cgggcacgtc atcgtcggcg acaccaagaa ccccaacggc cccgtcctca ccgtcaccaa
    19741 caccgactgg accaccttcc tcgaccaggt cgccaccgga acttccgact actccggccg
    19801 cctcatcccc gtcttccaac ccgacggcgg cttcatcctg cgcgacaccg ccacccaagc
    19861 gaccctggtc ttcacccgcg ccgaatggga cgccttccac gccggagtcg tccacggcga
    19921 actccgcccc ctggctgcgc tctgagactc ccgcgttggc agccctctga agcacagaca
    19981 gcaccgacag gagccggggg agggaacggg cgtgcacccg ctcgtccatt ccccgcccaa
    20041 ccggcagcgg ggccgaacag catgattgat gggacgggca cgacgacagc ctcgcccgac
    20101 ttctccgccc ggagggcgca ccaggcgccc agacaccgcc gtccgagtcc tgccgctgag
    20161 cgccggtgcc acacgcttgg tgcccaccag ggcttcactc tctgcccctg aacggacagc
    20221 cttccagaag gccctgcgtg gcaccggctt ccgctcgtcg taccaccggg cccagtctgc
    20281 tcacgcctgc cgaccgcagc cttgggctgc ctggactgga cacaggcgaa gcagcagtca
    20341 ccaggcacct cctgcctgcc cgactgcccg tgcgctgacg accacgcggc gatcactgcc
    20401 aggtgtccca tccttggacc ggcgcggtgg acgcctcccg ctccgcgccc ggtggcccag
    20461 cggggcaggc acgctgccgg acatcctgac cgtctccgcc agcccccgtc ccgctgcctg
    20521 ctccagggct ttcagacacc ttctggaaaa ctgcttccca ctgccttttc cctgccctca
    20581 cccctggcta tttccccggc atcctccaaa gaagccaagg atggattttc agtccgacct
    20641 tggaacagct ctcctttttt accctttcag gacccgcttt ccacaaagag gacagcggta
    20701 catcgatact ggtagaagct gttttctcca ttcccgttta cgcattggct ccgggggatg
    20761 tacattggtc cacgcaatcg cacggcgaaa aaaggcggca tcgaaatccg cgtgtcttcg
    20821 ctgtccgcgc cgccaatctt caccgactcc caacaagcaa aggaagccca tgactgatgt
    20881 ggccgccgat cccgagaacg cggcagaact aagggaccag gtcgtggaca ccctcatccg
    20941 ggacggcgtg atcgtctccc cacaggtcga ggcggcgatg cgcagggttc cacggcaccg
    21001 gttcacgccg gaggcaaccg tggaggaggc ctaccgcccc tatgcggccg tagtcaccaa
    21061 gaagaatgag cacgggatct ccatcagttc ggtctcagct ccccagatcc aggcgatgat
    21121 gcttgaacag gccgccatcg agccgggaat gcgggttctg gagatcggtt cgggcggcta
    21181 caacgcagcc ctgatcgctg aactcgtcgg cgattccggc caggtcacca ctgtcgacat
    21241 cgaccaggac gtcacggccc gggccgagcg gctgctggcg gagaacggat acccgcaggt
    21301 gcgcgtcgtc ctcgccgatg ctgaggacgg actcgctgcc cacgccccct acgacaggat
    21361 catcgtcacc gccggggcgt gggacatccc tccggcgtgg atcacgcaac tgaccgagcg
    21421 ggggcggctc gtggtgccgc tacggctgcg gggcctgacc cgttcgatcg cgttcgagcg
    21481 ccgcggtggc cacctgctcg gcctctccgc ccgggcgtgc ggattcgtcc ccatgcaagg
    21541 cgccggcgcc caccaggagc aactgctact gctgtgcggc acggacgaga tcggcctgcg
    21601 tttcgacgac gggctgccgg gggacccgag cctgctggac aacaccgtgc gcaccccccg
    21661 gctggaggtg tggaccgggg tggtggtcgg gcgcaccgaa ctggtcgaca ccctgcagtt
    21721 gtacctggcc acggccctgc ccgggttctg catcatggct gtcgaccccg cactggacac
    21781 gggcctggtc gagcccaacc acccctcgtt ctccctcgcg gcagtcgacg gcggcaactt
    21841 cgcctacctg cgggtccgtc ccacagccga cgaccggtcc gtggagtacg gcatccacgc
    21901 cttcggcccg cagcgggagg cgttcgccga gaagatggcc ggacacgtgc ggacctgggc
    21961 ccgcgagcac cgcggcggtc ccggcccgca gatccgcgtc ttcccggccc gcacccccga
    22021 cgagcaactg ccgggacacc tggtcctcga caagaagcac agccgcgtca cgttctcctg
    22081 gccctcggca acagccgcgg accaggccgt tccacccgcc tcttcggaag gagacgatca
    22141 ccggtgatga gcaccagcct cgctggcggt agcacggcac tggccgatcc ccccggaatc
    22201 gacgacgagt tcgcgctcga tgtgaaggtc gtcctggcca cccaccccaa cggcaagctg
    22261 cagtgcagca ccagtgacgg ctgcggcagc acctgtaacg acggcgcctc ggcctgcaac
    22321 tccagcatcg agcctcccct gtcctgatca cttgttcgca gtgctggtgt gccggacgtc
    22381 ctgtgcggca caccagcgct ccacctgagg aagggagccg cagtgcgacg gtcagcggtc
    22441 ggctaccggt ggcgaggcgg ggcgctgctg cgggccagca ctgcaccccc tggactggac
    22501 gtgccccgcg acccggctct gctcgacgac ggggccgtgc cccggcaacg ggcctggatc
    22561 gctgacgtct gggctcgcaa ggacgtacgg gacgccttgg ctgccgccag cccggcactg
    22621 tgtcggcagg tcgaggccgt ggtgtcagga gcatgcacgg aaccgcggcg agtgcgcaga
    22681 accgtccttt cgctggtttc ctacctgctg cgctggcagc ggcgcgctac ccccttcggt
    22741 ctgttcgcgg gcgtcgcccc cgtaggaacc gcacacgaac ccagtgtggc ctggggtgga
    22801 aaacaccagg tgtcagcccg gccggacggc gaatggctca ccgacgtcat cagccgcttg
    22861 gaccagtgcc gtgagctgcg tgaacggctg catgtcgttg ccaacgacac cgggcaggca
    22921 cggggcgacc ggttcgtggc gcctggaccg cccgctgacg gccgcgcacg gcacatggct
    22981 ccgctcgaag tatcggtacg ccgcactcgc cctgtggcag cggccctaga agaggcccgt
    23041 accccgatcc gttacgggga gctttgcgct cgtctcgccc gactgttccc caccgcggga
    23101 gaggaccgga tcagggcggt cctggacggc ctgatcgacc agaacctgct tgtgagcagc
    23161 ctgtggccgc cgatgacctg cctggacacc ctgggctatg tgtgcgctga actggacgcc
    23221 gtccgtgccc agggcatcga cgcgatcgcg cccctcgtgg cggaactccg cacgatccgc
    23281 gacgacctcg ccgaacgcag ccctggggcc cttgcagaaa gcagccggga ctccgtagtg
    23341 gagcggttat ggagttgcga tcctcagcca ccccggaggg tggctgccac acgctcccgc
    23401 acgacgacgc cttggttctg tagtggggtt gcgatcctca gccaccccgg agggtggctg
    23461 ccacacctgt cccgtgtaca cgctgcaagc cggtgcgggg ttgcgatcct cagccacccc
    23521 ggagggtggc tgccacagca cctgaagtgc gcaaacacca cattgcttgg cgacgctcac
    23581 gactcaaaaa agggtgaaag ttcccaagca gacacaaacc tccttgagaa cccccctgta
    23641 aatccatgac cacttcaggt tcccaaccac agcaccaaca agaccgcccc ggggaagaag
    23701 ccaggccgga tgctactcca ctcctccgac acagacctgg gaaccgactc ttgaatccaa
    23761 gagagcaaag atccccggcc gacgcggacc gtggtcacac cgtcccctga acctcctcac
    23821 ccgcaccatc cgcacccccg cccccgaccc ccccggtggg ttcccgatga tcttggcccc
    23881 agtgccctcc tcggtcgcgt tcatggctct ggggccatag ccgccagcgg ctctgggtga
    23941 ggcgcccgtg cggacgcttc cgtatctgta cgatccgtga ccatgacgac ggacgccgac
    24001 cggctgcccg gaacggccgc cgcggtcccc gtgccgggcc gacgcgggcg gcgcaacgac
    24061 cccggacgtc gcgaccggat catcgacgcc tgcctcgacg tcatcgtcga gcagggggtg
    24121 gcgggggcgt cgcaccgcaa gatcgccgcg gctgccgggg tgccgctggg gtcgatgacc
    24181 taccacttca ccgggatgga cgagttgctg cgcgaggcgt tccgccggtt cgcgctcggc
    24241 gtgtccgccc ggttcgagcg gcgcatgctc gacgcccgcg acgccgagga ggcgaaggcc
    24301 gcggtggtcg cgctgatcac cgccgacctc ctgagctccc ggcgcgacct ggtgctgacc
    24361 agtgagctgt acaccctcgc ggcccgcaaa ccggagttcc gggacctgac caaccggtgg
    24421 atggcccgtt cccgggccgc cctggaacgc catttcgacc cggtcaccgc ccgtctgctg
    24481 gacgccctga tcgaggggct gaccctgcac cgcggcctgg acaccgaacc gcacgacacc
    24541 gccgccgtgg tcgaggccgt ggaccggatc acccggtgcg ggaactgagg ggcggccgcg
    24601 gcctgtcgcc ggtccggcgg ccggttccgg cacgccgccc cgccccggtg ccagacgggc
    24661 ctgcgtgccg ggccccgggc gttccccctc cctcatagga acgctcccac aagtatgtac
    24721 gatcgtactc atgcctgccc cgctccggcg cctccgcctg tcgctgttcg ccctgaccct
    24781 gatcgtgggc ctgggaatct cctcgtgggt gacccgcacc cccgccatcc gcgacgcggt
    24841 ggacgcctcc accgccggga tgggagtcct cctgctcggc ctctcagtcg gctcgatggc
    24901 cggagtgctg accgcggggc cgttcgtgcg ccgcctgggc ggccgtcccg tgatcgcggt
    24961 cggcaccgtg ctggcggtcg ccggagtcgg cgtggtcgcc ctcgccaccg ccgcgtccct
    25021 gaccgccggg gtgttcgtcg ggctgctgct ggtgggggtc ggcgggggac tcggcgagat
    25081 cggcctgaac atcgaggccg ccgcggtcga ggccgccacc ggccgtcccg tcctgccgat
    25141 gctgcacggc agcttcagcc tcggcaccgt gatcggcgcc ctggtcggca tcggtctcac
    25201 cgccgtccgc ttccccgtgg tctggcacct gctggccgtc gccctcctca tggcggtgct
    25261 cgcgctctgg gccc
//
