LOCUS       NZ_CP051627            21041 bp    DNA     circular CON 21-APR-2024
DEFINITION  Thermobifida alba strain DSM 43795 chromosome, complete genome.
ACCESSION   NZ_CP051627
VERSION     NZ_CP051627.1
KEYWORDS    RefSeq.
SOURCE      Thermobifida alba
  ORGANISM  Thermobifida alba
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsaceae; Thermobifida.
REFERENCE   1  (bases 1 to 4903256)
  AUTHORS   Luzics,S., Horvath,B., Nagy,I., Toth,A., Nagy,I. and Kukolya,J.
  TITLE     Thermobifida alba genome sequencing and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4903256)
  AUTHORS   Luzics,S., Horvath,B., Nagy,I., Toth,A., Nagy,I. and Kukolya,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2020) NGS Platform, Seqomics Ltd., Vallakozok u.
            7., Morahalom 6782, Hungary
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: RA v. v0.2.1; CLC Genomics Workbench v. 11.0.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 331.0x
            Sequencing Technology             :: PacBio Sequel; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023208015.1-RS_2024_04_21
            Annotation Date                   :: 04/21/2024 13:45:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,356
            CDSs (total)                      :: 4,290
            Genes (coding)                    :: 4,246
            CDSs (with protein)               :: 4,246
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 44
            CDSs (without protein)            :: 44
            Pseudo Genes (ambiguous residues) :: 0 of 44
            Pseudo Genes (frameshifted)       :: 10 of 44
            Pseudo Genes (incomplete)         :: 35 of 44
            Pseudo Genes (internal stop)      :: 3 of 44
            Pseudo Genes (multiple problems)  :: 4 of 44
            CRISPR Arrays                     :: 12
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:37:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3334643
            Orig. end                         :: 3355684
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP051627.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21041
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="8"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21041
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21041
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11041](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11041)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    319..332
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.86"
                     /tool="antismash"
     misc_feature    complement(524..538)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.13"
                     /tool="antismash"
     misc_feature    791..805
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.18"
                     /tool="antismash"
     misc_feature    1185..1198
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.58"
                     /tool="antismash"
     misc_feature    1211..1224
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.13"
                     /tool="antismash"
     gene            complement(1262..1810)
                     /locus_tag="FOF52_RS14780"
                     /old_locus_tag="FOF52_14705"
     CDS             complement(1262..1810)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (13-174). E-value:
                     3.9e-19. Score: 61.4. Matches aSDomain:
                     nrpspksdomains_FOF52_RS14780_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017556316.1"
                     /locus_tag="FOF52_RS14780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_14705"
                     /product="SRPBCC family protein"
                     /protein_id="WP_248590540.1"
                     /transl_table=11
                     /translation="MDISIIDTSPLFDLSARILVAAPPDQVYAVVSDLPRSGEWSPECR
                     GGEWVSGEPGAVGAVFRGENCRPEDVVGWAPLVRGVWHTEARVVAAEPGRTFRWMMLSH
                     AGADQESIWGFDIEPDEKGSVLVHHFRMGRATVGIHKIVADMDEADRKRFIEDWTAKLE
                     RDLDETLHRIKGAIEGQRD"
     aSDomain        complement(1289..1771)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FOF52_RS14780_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="3.90E-19"
                     /label="FOF52_RS14780_Polyketide_cyc2.1"
                     /locus_tag="FOF52_RS14780"
                     /protein_end="174"
                     /protein_start="13"
                     /score="61.4"
                     /tool="antismash"
                     /translation="LSARILVAAPPDQVYAVVSDLPRSGEWSPECRGGEWVSGEPGAVG
                     AVFRGENCRPEDVVGWAPLVRGVWHTEARVVAAEPGRTFRWMMLSHAGADQESIWGFDI
                     EPDEKGSVLVHHFRMGRATVGIHKIVADMDEADRKRFIEDWTAKLERDLDETLHRIK"
     gene            complement(1882..2868)
                     /locus_tag="FOF52_RS14785"
                     /old_locus_tag="FOF52_14710"
     CDS             complement(1882..2868)
                     /NRPS_PKS="Domain: PKS_ER (18-318). E-value: 1.5e-36.
                     Score: 118.0. Matches aSDomain:
                     nrpspksdomains_FOF52_RS14785_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017556317.1"
                     /locus_tag="FOF52_RS14785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_14710"
                     /product="NADPH:quinone reductase"
                     /protein_id="WP_248590541.1"
                     /sec_met_domain="ADH_N (E-value: 4e-12, bitscore: 44.0,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 3.3e-21, bitscore:
                     73.7, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAAFIENFGPPDAIRCGELPQPRPGPTDVLVDVEVTTVNHVDTF
                     VRSGAWRTPVEFPFVIGRDLVGTVAEAGPGAPGFSVGDRVWCNSLGYGGRQGAAAERVV
                     VPRDRLYHLPAGVSPEDAVAVAHPAATAYLGLFTHGRLRAGETVVVAGAGGNVGGALVA
                     MAAQAGAKVVAVAGSYDADHCRSLGASEVVDYRAPDVVERIAALCPDGVDLYADAAGRN
                     NVAEVVDLLARRGRLVLLAGMHTRAVLPVGALYTRDRSVIGFAISQADAGELAEAAGHV
                     GRMLAEKRLAPRRVEVLPLAAAAEAHRRVEAGEGAGRRFVLHTGPRA"
     aSDomain        complement(1915..2814)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FOF52_RS14785_PKS_ER.1"
                     /evalue="1.50E-36"
                     /label="FOF52_RS14785_PKS_ER.1"
                     /locus_tag="FOF52_RS14785"
                     /protein_end="318"
                     /protein_start="18"
                     /score="118.0"
                     /tool="antismash"
                     /translation="ELPQPRPGPTDVLVDVEVTTVNHVDTFVRSGAWRTPVEFPFVIGR
                     DLVGTVAEAGPGAPGFSVGDRVWCNSLGYGGRQGAAAERVVVPRDRLYHLPAGVSPEDA
                     VAVAHPAATAYLGLFTHGRLRAGETVVVAGAGGNVGGALVAMAAQAGAKVVAVAGSYDA
                     DHCRSLGASEVVDYRAPDVVERIAALCPDGVDLYADAAGRNNVAEVVDLLARRGRLVLL
                     AGMHTRAVLPVGALYTRDRSVIGFAISQADAGELAEAAGHVGRMLAEKRLAPRRVEVLP
                     LAAAAEAHRRVEAGEGAGR"
     gene            3127..4086
                     /locus_tag="FOF52_RS14790"
                     /old_locus_tag="FOF52_14715"
     CDS             3127..4086
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017626039.1"
                     /locus_tag="FOF52_RS14790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_14715"
                     /product="UbiA family prenyltransferase"
                     /protein_id="WP_248590542.1"
                     /transl_table=11
                     /translation="MSASTRSVPQGVLYTVGKFARLVKYQFVLDFLLALVIVWTALEPA
                     ERLSGVTLTTLLLFALGQVGVLFAVMTLDDVTGIKDGSDTANYVHAGKTALRPLKRKPL
                     LTGELTVRQAQWYGYASLAWGALWWTATVLYTPHRPLWVLVVTVLLLVLSVQYSWGLKL
                     SYIGLGEALLLFSASAFVIAPHGLATGEWSALLLTEGLLFGFGQLLIAGYSNTNDIPGD
                     RAVGRRTVAVLTSPRGNRIFLGLLTACNLLVLLVPAFAGWLPWWFPVVLLPFAVLRVHQ
                     YVGFLRGGDPLLARKRGVVVFRTVVACSVVFNLLYHAL"
     gene            complement(4125..6512)
                     /locus_tag="FOF52_RS14795"
                     /old_locus_tag="FOF52_14720"
     CDS             complement(4125..6512)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.4"
                     /locus_tag="FOF52_RS14795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_14720"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_282573505.1"
                     /transl_table=11
                     /translation="MRIVPRSPIGFTQVIAEQASTVPAHFPTPLIGREAEFAALRDKIT
                     SPEIRMVTITGAAGAGKSRLASALYTDVSGEFEDGGCFLVLDGARSREELLQTLIGALR
                     TGDADTADTPLECLAEYLGKRHFLLVLDGCDELLESLPTVLVSLVAACPRLTVLVTVCE
                     PLGIYGEDLFRLAPLAVPDPEGDSDLAELEKVASVRLFIQRTRAVRPGFALTTENRHAV
                     AQLCVRTDGLPLAIELAAARMKLSSPQALLESLDRDLDVLSVAGSNTLSRHSCMRSAIT
                     WHLLRLHPADQEFLGRVAAFHAGFDLPAARGVGGVGEAETQRRLEQLIDKNLLHVGECP
                     DGDITFQMAGLTRQYVLEWLRETGRYTEVLRGHADYMLSMSESVRDELTGPEQAHHLSR
                     LDQWHTDLEKALRFLNDNGDEAGAVRLVCALRSYWQAVGRSRTGARFLEKALDTAELPT
                     EVRIEGAATLGELKTVMGEYDEAHRHLVHALRGYRQAGDTAAEASCRKGLGTLAYHRGD
                     LDQAARLLEESATALRKAGDTVAHAAALRDLAECHLAGGDPAAARAPAETALRESTRRG
                     DRRAVALANRVLADVEFAVGNQDRAERLHRTSLEELHSLGDRGSCATGLERFAVLLARR
                     YGRVTKSWRRTARGLGAARALRAATGCAAPRPLAAVIEEVREQARIRLGDDAFDEEWRA
                     GRSAGVHAVLAEMTAPLDLSITERQRRYGADVPLTQREIEVAELVARGMTNREIARRLG
                     IAEWTAVNHLRKVMRKLDCSSRVHVASWVTRREREEQERAGS"
     misc_feature    complement(5652..5654)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6927..8075)
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /locus_tag="FOF52_RS14800"
                     /old_locus_tag="FOF52_14725"
     CDS             complement(6927..8075)
                     /EC_number="1.17.7.1"
                     /GO_function="GO:0046429 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate synthase activity [Evidence IEA]"
                     /GO_process="GO:0044237 - cellular metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017538923.1"
                     /locus_tag="FOF52_RS14800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_14725"
                     /product="flavodoxin-dependent
                     (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase"
                     /protein_id="WP_248593875.1"
                     /transl_table=11
                     /translation="MPKVRDPDGAALAERRQSRRIMVGDVAVGGDAPISVQSMTTTVTA
                     DINATLQQIAELTAAGCQIVRVAVPSADDAEALPVIARKSQIPVVADIHFQPRYVFAAI
                     EAGCAAVRVNPGNIKKFDDRVGEIAKAASEAGVPIRIGVNAGSLDRRLLAKYGRATPEA
                     LVESALWECSLFEEHGFRDIKISVKHNDPVVMVQAYRLLAQRCDYPLHLGVTEAGPAFQ
                     GTIKSAVAFGALLAEGIGDTIRVSLSAPPAEEVKVGAQILESLGLRQRGLEIVSCPSCG
                     RAQVDVYTLADRVTAGLQGLDVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKG
                     EVIKTVPESQIVETLIEEALRIAEEMRAEGVASGEPSVDVAG"
     gene            complement(8093..9946)
                     /locus_tag="FOF52_RS14805"
                     /old_locus_tag="FOF52_14730"
     CDS             complement(8093..9946)
                     /EC_number="2.2.1.7"
                     /GO_function="GO:0008661 - 1-deoxy-D-xylulose-5-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017557589.1"
                     /locus_tag="FOF52_RS14805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_14730"
                     /product="1-deoxy-D-xylulose-5-phosphate synthase"
                     /protein_id="WP_248590544.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 4.4e-84,
                     bitscore: 279.9, seeds: 174, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.5e-07, bitscore:
                     27.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLLETVDGPAQLRGMTITELTELAGEIREFLIEHVSRTGGHLGP
                     NLGVVELTIALHTVFESPRDRLLWDTGHQSYVHKLLTGRQSGFDRLRQAGGLSGYPSRA
                     ESEHDLVENSHASTALSYADGLARADAYRGHTDRAVVAVIGDGAMTGGMAWEALNNLAD
                     GPDRPLVIVLNDNQRSYAPTRGGVADHFSALRAGHDGPGVFEQLGLAYTGPVDGHDIGA
                     LQEALRRARALGRPVVVHVVTEKGRGFVHTENNELDRGHTVKPMDPRTGKALAPSTKGR
                     SFTSVFGERIVEIAAERPDVVAITAAMLEPTGLLPMRQRFPDRVIDVGIAEQHAVTMAA
                     GLAMGGVHPVVAVYSTFVNRALDQVLMDVALHRCAVTFVLDRSGITGNDGPSHNGMWDM
                     SVLQVVPGLRIAAPRDGARLAELLDEAVAWSEGPTLVRFPKGPTGEDLPAEMTFAGMDV
                     LRRSGSLDVLVVSVGALARVALGVAEGIRAQGIGVTVIDPRWVSPVNPGLADVARRHRL
                     VVTIEDNSRIGGIGATISQTLRDAGVSTPLREFGVPRRFLGHGSRDDVLSECGLTVQDI
                     SLAVVGAVADLDGGNGYSTLDGIDGALARLLLRHRSGKEER"
     gene            complement(10001..11041)
                     /locus_tag="FOF52_RS14810"
                     /old_locus_tag="FOF52_14735"
     CDS             complement(10001..11041)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017623806.1"
                     /locus_tag="FOF52_RS14810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_14735"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_248590545.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 9.6e-43, bitscore:
                     144.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTAADVRALRNRLMEQVEARLTDLLDTERKRWAEVDPRAAVPV
                     DAVADLVAAGGKRLRPAFCVSGYLAAGGDPGDRAVVDCAAALELVHAGALIHDDVLDAS
                     DLRRGAPAVHTRYTAEHRFRGWRGEARRYGEGTAILSGDLANILADRLTQSLPARARPL
                     WNELLTEIIIGQFLDVTVAAEGVVDPELSRWIAVCKSGRYSIHRPLLLGALVAGREDLA
                     ATFEEYGEALGEAFQLRDDLIDAFGRSEAAGKPVGLDLEQHKMTLLLALAVRRDPRVRE
                     LVDSPEWDVPALRDLLSGSGIRTEIERRIDGLVARAVAAVNQAELDEAWRGELVVMARE
                     VAYRDR"
     gene            complement(11038..12012)
                     /locus_tag="FOF52_RS14815"
                     /old_locus_tag="FOF52_14740"
     CDS             complement(11038..12012)
                     /EC_number="1.17.7.4"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051745 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate reductase activity [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011290918.1"
                     /locus_tag="FOF52_RS14815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_14740"
                     /product="4-hydroxy-3-methylbut-2-enyl diphosphate
                     reductase"
                     /protein_id="WP_248590546.1"
                     /transl_table=11
                     /translation="MLPAKKVLLAEPRSFCAGVRRAISIIELALERHGAPVYVRKEIVH
                     NHYVVRQLRQRGAVFVDSEEEVPEGAVCVFSAHGVSPQVRRNAEDRRLDVIDATCPLVS
                     KVHQEALRFSREERTLLLVGHADHEEVEGTYGHAPDRTVIIETVEDARQLDLPADTPVA
                     YLTQTTLSVDETRDIIDTLRSRFTDLRGPATDDICYASQNRQDAIKAIAPRSDLVLVVG
                     SRNSSNSNRMVEVARRMGVPAHLVPEAGELDPAWLDGVRTVGVSAGASAPETLVEELME
                     RLAVFGFEDVEIEQVAREDVVFSPPARLTRQDAESSLSRGGRA"
     misc_feature    complement(12163..12183)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.0"
                     /tool="antismash"
     misc_feature    12203..12218
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.78"
                     /tool="antismash"
     gene            12287..13504
                     /locus_tag="FOF52_RS14820"
                     /old_locus_tag="FOF52_14745"
     CDS             12287..13504
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024935.4"
                     /locus_tag="FOF52_RS14820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_14745"
                     /product="transposase"
                     /protein_id="WP_248590547.1"
                     /transl_table=11
                     /translation="MNTITQEAVGDLQKHAGATTPVQPRKYSGNLSEPVFEELSETLFA
                     SLRRSDQRRRGLDYLRGLLRTPGRKSIRNMAALLGGSGTGQSLHHFICNSTWEWSPVRA
                     ALAGYLARVAPPLAWVVRPMVIPKTGQHSVGVGRYFSPVDGQVLNAQQAVGLWAVSDRT
                     GVPLNWHLRLPEQWHDVSDCGVPSPRPAPPRPLGDCAVEMCREALADWGLPPRPVVVDI
                     GEANPLPTLRRLTAEGLSSMVRVPGDLPLTVVDEALTGHRGNILPAAQIMRAARELRRP
                     VTWRERGPRPVRRTALVAAVRVRSHPDCGRDTVLVGIGGIGAEWLTELWATSLPASWAA
                     TAVPWMSGFVRAVDRDFETISEHVGIRDYVGRSFSGWHRHVTLASAAHAVVALSSTPAD
                     LVGHAS"
     gene            13662..14834
                     /locus_tag="FOF52_RS14825"
                     /old_locus_tag="FOF52_14750"
     CDS             13662..14834
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017626044.1"
                     /locus_tag="FOF52_RS14825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_14750"
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="WP_248590548.1"
                     /transl_table=11
                     /translation="MYSGLPVTRLGPAPQQPDWADDPRLPAARRELALLPPLVRPEDVD
                     RLRLLLARVAAGEALVVLAGDCAEDPAESTAADVAAKTGLVETLARMVGSASGKPVVRA
                     ARIAGQFGKPRSRSTETVGGRELPVYRGHLVNSPEPDPELRRPDPLRLVACYRAAAEIM
                     GHLGWRPDLPRHDADAPVWTSHEALLLDYEVPLLRRTGDGRVLLASTHWPWVGERTRSA
                     DGAHIALLSGIANPVACKVGPTTETDELLEVCERLDPRRVPGRLTLIARMGAGVVARRL
                     PPLVEAVRAAGHPVVWLTDPMHGNTVRTPSGLKTRYVEAIVREVQEFHSAVRSAGGVPG
                     GLHLEATPQDVTECVPDRFHVDRVPAKYTSLCDPRLNPDQAVAVAAAWLH"
     gene            14894..15664
                     /locus_tag="FOF52_RS14830"
                     /old_locus_tag="FOF52_14755"
     CDS             14894..15664
                     /EC_number="1.3.1.28"
                     /GO_function="GO:0008667 -
                     2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (4-164). E-value: 5.5e-17. Score:
                     54.2. Matches aSDomain:
                     nrpspksdomains_FOF52_RS14830_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) EntA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017611892.1"
                     /locus_tag="FOF52_RS14830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_14755"
                     /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase"
                     /protein_id="WP_248590549.1"
                     /sec_met_domain="EntA (E-value: 2e-109, bitscore: 363.1,
                     seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 2.2e-37, bitscore:
                     126.7, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 3.4e-29, bitscore:
                     100.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEDSVALVTGAASGIGAAVARALGERGATVAAVDRDAEQLRTLVD
                     KLRADGARVEAFAADVSLASEVEGVVREVERTLGPLHSLVNAAGVLRLGGVRDLTDDDW
                     SATFAVNATGVFHTSRAAARRMVPRRRGAIVTVASNAAGTARMGMAAYAASKAAATAFT
                     RCLGLELAAYGIRCNVVAPGSTDTPMLRSMWHDASGPAATLRGDPEAYRVGIPLQRLAQ
                     PADIADSVLFLLSDQAAHITMHTLTVDGGATLGC"
     aSDomain        14906..15385
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FOF52_RS14830_PKS_KR.1"
                     /evalue="5.50E-17"
                     /label="FOF52_RS14830_PKS_KR.1"
                     /locus_tag="FOF52_RS14830"
                     /protein_end="164"
                     /protein_start="4"
                     /score="54.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGAASGIGAAVARALGERGATVAAVDRDAEQLRTLVDKLRA
                     DGARVEAFAADVSLASEVEGVVREVERTLGPLHSLVNAAGVLRLGGVRDLTDDDWSATF
                     AVNATGVFHTSRAAARRMVPRRRGAIVTVASNAAGTARMGMAAYAASKAAATAFTR"
     CDS_motif       14912..14977
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FOF52_RS14830_0001"
                     /evalue="1.90E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="FOF52_RS14830"
                     /protein_end="28"
                     /protein_start="6"
                     /score="17.3"
                     /tool="antismash"
                     /translation="LVTGAASGIGAAVARALGERGA"
     misc_feature    15011..15013
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15834..16517
                     /locus_tag="FOF52_RS14835"
                     /old_locus_tag="FOF52_14760"
     CDS             15834..16517
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630447.1"
                     /locus_tag="FOF52_RS14835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_14760"
                     /product="isochorismatase family protein"
                     /protein_id="WP_248590550.1"
                     /transl_table=11
                     /translation="MTGIPPIRPYPLPEADGLPANTACWTVDPDRAVLLVHDMQRFFLR
                     PFDSAGEPCRTLLRNCVALRERCAALGVPVAYTTQPGNMTDEQRGLLKDFWGPGMSAVP
                     QDRAVVEPLAPAPGDWVLTKWRYSAFHRSDLLELMRAHHRDQLVVCGVYAHVGVLMTAV
                     DAFTHDIRPFLPADAVADFSAEYHHMALEYAAQRCAVVTSTAALLAALGSAVLDSPELA
                     VEART"
     gene            16514..18403
                     /locus_tag="FOF52_RS14840"
                     /old_locus_tag="FOF52_14765"
     CDS             16514..18403
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018: isochorismate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017626047.1"
                     /locus_tag="FOF52_RS14840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_14765"
                     /product="anthranilate synthase family protein"
                     /protein_id="WP_248590551.1"
                     /transl_table=11
                     /translation="MSGGGTGNADLLGSILAAPPPAFALLYRPETSCPEVVDVLVGEVS
                     TPEVLAALPLPPRDRRTGRAGHDVLAVIPYRQLTERALPCNDDGAPLIAMTVTAQETVA
                     LADLLGRIPDWGIRVANGRFDVSDEAYAAAVERIIAEEIGQGEGANFVLGRSYLAEIAD
                     YTPHSALTLFRRLLEQESGASWTFVVHAAGRTFVGATPERHISLRGGVAVMNPISGTYR
                     YPPSGPDLAEVMLFLSDRKEADELYMVVDEELKMMARICNSGIRVDGPRLKEMARLAHT
                     EYYIKGHTGRDPREILRETMFAPTVTGSPLESAFRVISRHEPRGRGYYSGALALIGHDE
                     RGDRTLDSAILIRTAEIAPDGRMRIGVGATLVRHSDPAAEAAETRAKAAGLLAALETAR
                     PTRLADHPAVRTALDERNMHLSSFWLDGNAESTPVPELAGLCALVIDAEDAFTSMLAHQ
                     LRSIGLAVTVRRFDEPYSFDEHHLIVMGPGPGDPRDSSHPKIARLEAAIRTLLAERRPF
                     LAVCLSHQVLSRTLGFALHRRAVPNQGVQHRIDLFGHRERVGFYNSFAAVSSEDKVECE
                     GTGTVEVSRDAETGEIHALRGPGFASLQFHAESVLTHDGVRLLARTVREILGR"
     gene            18450..19022
                     /locus_tag="FOF52_RS14845"
                     /old_locus_tag="FOF52_14770"
     CDS             18450..19022
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017619615.1"
                     /locus_tag="FOF52_RS14845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_14770"
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="WP_248590552.1"
                     /transl_table=11
                     /translation="MTNTPLRLAVVIGSIREGRFGPTVAQWITEEARSFGQFDVDVVDL
                     ADAGLPMRITDTAPPEVEALRPRLAAADAFIMVVPEYNRGYPASLKTLIDWYIEEWQAK
                     PVGFVSYGGRGGALRSVDHVSAVLSDLHAVPLRDTVSFHDAWDKFDASGRPVDREGAEA
                     AAKILLDRLLWWGSALRSARLEHPYNR"
     gene            complement(19080..20471)
                     /locus_tag="FOF52_RS14850"
                     /old_locus_tag="FOF52_14775"
     CDS             complement(19080..20471)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017556324.1"
                     /locus_tag="FOF52_RS14850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_14775"
                     /product="NDP-hexose 2,3-dehydratase family protein"
                     /protein_id="WP_248590553.1"
                     /transl_table=11
                     /translation="MAVQRNPSVLPRPRWEPGTAERMARSVAARGDERTVRETADWVAG
                     RAASEGFRVEPIPLAGLDGWRFDERTGNLAHHSGRFFTVEGLHVTVRNGPFPEWCQPVI
                     HQPEVGILGILAKEFDGVLHFLMQAKMEPGNPNLVQLSPTVQATYSNYTGAHRGRKVHH
                     IDYFVQPGRGRVLVDVLQSEHGAWFYRKSNRNMIVEVTEDVAPHEDFRWLTLGQIGRLL
                     RRDNLVNMDSRTVLSCAPVPEDGTEALHTDTELLSWLTGERTRYGVTARRVPLASVPDW
                     EREEYAIRHREDRYFRVVAVAVEAGTREVGRWTQPLFEPYRRGVIAFLTRRLGGVPHVL
                     VHARVEGGLPGVVELAPTVQCDPGNYAHLPPGRRPPFLDVVLSAPPGRVRYEAVHSEEG
                     GRFRGAENRVMVVEADEDEAPLSPPPGYRWVTPGQLRALVRHGHYLNVQARTLLACLNT
                     GAAVL"
     misc_feature    20584..20598
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
ORIGIN
        1 cccatccgcc accagccgtc gttcagctgt ccccgccacc gctcgtgctc gcccaggtag
       61 gtgacgatcc gcccgtcgct gcgcacctcg atgtagcccg gtgaggactt ggtcggcttc
      121 ttgccgtcgc ggctgaccac acgcaccgcc gtcatcccgg ggaagggcct gccgacgcac
      181 cgcccgtccg cctccgtccc gcggcgcctg gtgtaggtcc gcgcggcgat cgggccgacc
      241 tcgctctgcc cgtacgcctg cgcgaacagc ggcatgctgc ggcgcgacgc ctccagcatg
      301 cgctgcaccg tcctgggatg gatcgcgtcg aaggtactgc tgaagtacct cacgttggcc
      361 agcggctcgc gcgggtcgtc cgccaagacc tcccagcgca ggaacgtgtt ggggtgggcc
      421 tcgatgaacc ccgggcggat cctggcgaac agccgcgcca cactctcggg ttcgtcgtcg
      481 cgcaggacga tgagcggatg cccctggagt acggagatcg gcatggccgt gtacatccgg
      541 gagtggacga aggacacgtg gaccgcgatg ggctcgctct tgcccaccag cgacatcacc
      601 gtcgcctggg gacggtagcg ggcctggagc gtgcggccgg tgtgcaccgc cagcttcggg
      661 atccccgtgg tccccgaggt gtgtgtgatc agcgtgggat ggtccggagg catggtcacg
      721 ggacgcaccc gctccgtgcc ctccagcgag gcgagcggga ccgcgccgtc gtactcaccg
      781 gacgcgagga tgacgcgctc ggccagctcg aagacctcgc cgggcagctc cttctccagt
      841 ttcgcctggt cggtcagcag gtagggctgg tccacacggc gcagcagctc caccaccgtg
      901 ttcccgtcca gcttcggcga cagcatcacc gggatggctc cgatcctcgc cagggagcag
      961 gccaggacgg agatgtcgaa accgtccgtc ttgtggacga ccacgtggtc ccccggacgg
     1021 atacgcagag cccacagccg ggaggcgatg tcgtccacga ggtcggcgac ctcggtgagg
     1081 gtcagccggc gtccccggtc cggagcgatg tcgagatcgt ggtcgaggat gacgggattc
     1141 gccgggtacc gggccgcggc ccggtcgaag agcgtgccca gcctgatacc tctgtttgct
     1201 attcgctgta ggaacatgcg ctcgtccgtc ctgtcgtccc gtacctgcgg gttgccctgt
     1261 cctagtcccg ttgtccttcg atggcgccct tgatccggtg cagcgtctcg tcgaggtcgc
     1321 gctccagctt cgcggtccag tcctcgatga accgcttgcg gtccgcctcg tccatgtcgg
     1381 cgacgatctt gtggatcccg acggtggcgc gtcccatccg gaagtggtgg accagcacgg
     1441 agcccttctc gtcgggttcg atgtcgaacc cccagatgct ctcctggtcg gctccggcgt
     1501 gggagagcat catccagcgg aaggtccgtc ccggttcagc cgcgacgacc ctcgcctcgg
     1561 tgtgccagac gccgcggacg agcggcgccc agccgacgac gtcttcgggg cggcagttct
     1621 cgccgcggaa caccgctccc acagcccccg gctcgccgga gacccactca ccgcctcggc
     1681 actcgggact ccactccccg cttctgggca ggtcgctgac caccgcgtag acctggtcgg
     1741 gcggagcggc gaccaggatc cgagcactga ggtcgaagag gggcgaggtg tcgatgatgg
     1801 agatgtccat gtcccgatcc tgcgcacgca tcgtcgcacc gtgccaaaga ttggagcagg
     1861 attggtcaag tcagcctccc atcaggcacg gggaccggtg tggaggacga aacgccgtcc
     1921 cgccccctcg ccggcctcca cccggcggtg cgcctcggcc gccgcggcca ggggaagcac
     1981 ctcgacccgg cggggcgcca gccgcttctc cgcgagcatg cgccccacgt gtccggcggc
     2041 ttcggcgagt tccccggcgt ccgcctggga gatcgcgaaa ccgatgaccg accggtcccg
     2101 cgtgtagagg gcgcccaccg gaagcacggc ccgggtgtgc atcccggcca gcagcaccag
     2161 ccgtccccgc ctcgccagca ggtcgacgac ctccgccacg ttgttgcgcc ccgccgcatc
     2221 ggcgtagagg tcgacgccgt ccgggcagag ggccgcgatg cgctccacga cgtcgggggc
     2281 ccggtagtcg accacctcgg aggcgcccag ggagcggcag tggtcggcgt cgtaggaacc
     2341 cgccacggcg acgaccttcg caccggcctg tgccgccatg gcgacgagcg cgccgcccac
     2401 gttgcccccc gctccggcga cgaccaccgt ctccccggcg cggaggcggc cgtgggtgaa
     2461 caggccgagg taggcggtgg cggccggatg ggcgacagcc acggcgtcct ccgggctcac
     2521 ccccgcgggc aggtggtaca gccggtcccg ggggaccacc acccgttccg cggcggcccc
     2581 ctgccttccc ccgtatccga ggctgttgca ccacacccgg tcaccgacgg agaagccggg
     2641 ggctccgggg ccggcctcgg cgacagtgcc gaccaggtcg cggccgatca cgaaggggaa
     2701 ctcgaccggt gtccgccacg cccccgaacg gacgaaggtg tccacgtggt tgacggtggt
     2761 cacctcgacg tcgaccagga cgtcggtggg gccgggacgg ggctggggca gttccccgca
     2821 gcggatggcg tcgggaggcc cgaagttctc gatgaaagcc gcacgcatgt ctcgggagca
     2881 tgaccggtcg gcccacccgg cggcgcgtca acgggcagag tttgtcagat cttccttccc
     2941 gaacggctcg tccacgacgg aaccgggctc ccccgtggca aggactccca gctcacagcg
     3001 gccctctgcg tcctctgagc cagaaattgc tatttcccgc ccttttcaac gccaatacgg
     3061 ttccctgcca aaggaatccg gtatttctcc ggagattcgc gacgagtcgg gaaccgccct
     3121 atgcctgtga gcgccagcac ccgttccgtt cctcaagggg ttctgtacac cgtcggaaag
     3181 ttcgccagac tggtcaagta ccagttcgtc ctcgactttc ttctggctct ggtcatcgtg
     3241 tggacagcgc tcgaaccggc ggagcggctg tccggtgtca ccctgaccac cctgctcctc
     3301 ttcgccctgg ggcaggtcgg cgtcctcttc gccgtcatga cgctggacga cgtcaccggg
     3361 atcaaggacg gcagcgacac cgcgaactac gtgcatgcgg ggaagacggc cctgcgtcca
     3421 ctgaagcgca agccgctgct caccggcgag ctgacggtgc gccaggcaca gtggtacggg
     3481 tacgcgagcc tcgcgtgggg agcgctgtgg tggacggcca ccgtgctgta cacaccgcac
     3541 cggccgctgt gggtcctcgt cgtcacggtt ctgctgctgg tcctgagcgt gcagtactcg
     3601 tgggggctga aactcagcta catcgggctg ggtgaggccc tgctgctgtt ctccgcgtcg
     3661 gcgttcgtca tcgcaccgca cggcctggcc acgggggagt ggtccgcgct cctgctgacc
     3721 gagggcctgc tgttcggctt cggccaactg ctcatcgcgg gctactccaa caccaacgac
     3781 atccccggtg acagggcggt gggccgccgt accgtcgcgg tgctcacctc tcctcggggc
     3841 aacaggatct ttctcggcct gctcaccgcc tgcaacctcc tggtgctgct ggtacccgcg
     3901 ttcgcgggat ggcttccgtg gtggttcccg gtggtgctgc tcccgttcgc ggtcctgcgt
     3961 gtgcaccagt acgtggggtt cctgcgcggc ggggacccgc ttctggcacg caagcggggg
     4021 gtcgtggtct tccgcaccgt ggtggcctgt tccgtggtgt tcaacctcct gtaccacgcg
     4081 ctctgacggg gtccggcagc gtaccgccgc cagaccccgc ccgttcagct ccctgcccgt
     4141 tcctgttcct cccgttccct ccgggtcacc cagctggcca cgtggacccg cgacgagcag
     4201 tcgagcttgc gcatcacctt gcggagatgg ttgaccgccg tccactccgc gatgcccagt
     4261 cgccgcgcga tctcgcggtt ggtcattccg cgggcgacca gttcggcaac ctcgatctcg
     4321 cgctgggtca gcggcacatc cgccccgtag cgccgctgcc tctccgttat ggagaggtcc
     4381 agcggcgccg tcatctcggc cagcacggca tgcacccccg cagaccgccc ggcccgccac
     4441 tcctcgtcga aggcgtcgtc tcccaggcgg atccgggcct gctcccgtac ctcctcgatc
     4501 actgcggcga gcggtcgggg cgccgcacag ccggttgcgg cccgcagtgc ccgcgcggcg
     4561 ccgagccccc gcgcggtccg ccgccagctc ttggtcacac gcccgtagcg tctggccagc
     4621 aggacggcga accgctccag accggtggcg caggatcccc tgtccccgag ggagtgcagc
     4681 tcctccaggg aggtacggtg gagccgctcg gccctgtcct ggttgccgac cgcgaactcc
     4741 acgtcggcga ggacgcggtt ggcgagcgcg acggcgcgtc tgtcccccct gcgggtggac
     4801 tcccgcaacg cggtctcggc cggggcccgg gcggcagccg ggtcccctcc ggccaggtgg
     4861 cactcggcca ggtcgcgcag tgccgccgcg tgggccacgg tgtctcccgc cttccgcagc
     4921 gcggtcgcgc tctcctccag gagacgggcg gcctggtcga ggtcaccccg gtggtaggcg
     4981 agggttccca gccccttccg gcaggaggcc tcggcggcgg tgtccccagc ctgccggtag
     5041 ccgcggagcg cgtggaccag atgcctgtgc gcctcgtcgt actcgcccat caccgtcttg
     5101 agctcaccga gtgtcgcggc gccctcgatg cggacctcgg tgggcagctc cgccgtgtcg
     5161 agcgccttct ccaggaaacg cgctcccgta cggctccttc ccacggcctg ccagtaggac
     5221 cgcagcgcac agacgaggcg tacagccccg gcctcgtccc cgttgtcgtt caggaagcgc
     5281 agcgccttct ccagatccgt gtgccactgg tccagtcggc tcaggtggtg ggcctgctcc
     5341 ggcccggtga gctcgtcgcg caccgattcg ctcatggaca gcatgtagtc ggcgtggccc
     5401 cgcagcacct cggtgtaccg cccggtctcc cgcagccact ccagcacgta ctgcctggtg
     5461 agaccggcca tctggaaggt gatgtccccg tcggggcact cccccacgtg gaggaggttc
     5521 ttgtcgatga gctgctccag acggcgctgc gtctcagcct cgccgacccc gcccaccccc
     5581 cgggctgccg gaaggtcgaa ccccgcgtgg aaggccgcga cccgtcccag gaactcctgg
     5641 tcggcggggt gtaaccgcag caggtgccag gtgatcgccg accgcatgca ggagtggcgg
     5701 gacagggtgt tgcttcccgc caccgagagc acgtccaagt ccctgtcgag gctttcgagc
     5761 agcgcctgcg gtgacgacag cttcatccgg gcggcggcga gttcgatcgc cagcggcagc
     5821 ccgtcggtcc ggacgcacag ctgggcgacc gcgtggcggt tctccgtggt gagggcgaat
     5881 ccgggacgta ccgcccgggt ccgctggatg aacaggcgta ccgacgccac cttctccagt
     5941 tcggccaggt cgctgtcgcc ctcgggatcg ggtacggcca gaggagccag cctgaacagg
     6001 tcctcaccgt agatcccgag gggctcgcag acggtgacca gtaccgtcag ccgcggacag
     6061 gccgccacca gggagaccag gacggtgggc agcgattcca aaagttcgtc acatccgtcc
     6121 aaaacaagca ggaagtgacg tttgcccagg tattcggcaa ggcattccaa cggagtgtcg
     6181 gcggtgtcgg cgtctcccgt ccggagtgct ccaatcagcg tttggagcag ctcttccctg
     6241 ctccgtgcac cgtcgagcac cagaaaacac ccgccgtcct cgaactcccc ggagacgtcc
     6301 gtgtagaggg ccgaggccag tcgacttttt cctgctccgg cagcccccgt gatcgtgacc
     6361 attcgaatct ccggagaggt gatcttgtct cggagagcgg cgaactcggc ctctctaccg
     6421 atgagcggtg tggggaaatg ggccggaact gtactcgcct gctccgcaat gacctgggta
     6481 aaccctatgg gactccgtgg gacgatgcgc acttactccc ctttccgaca gcttacgtaa
     6541 cgggcagacc ggcgccagac accgagaagg aaactaccca tagtgccacc aaaactccac
     6601 aggggaacaa ggagttcttt tcccatccat cacccccgag ccgcctcatc acctcccatc
     6661 ccctcccact tcctccaaga actcccatca ggtcgtcctg ctccctccaa ggtgaggccc
     6721 ctccggaggt gccggcacaa agacaccgcc ggggaaactc cggtccggtg tgaatacaga
     6781 gaaagaagag gcggccccgg tggttcaggg ctgcctcttt aggtgtttca tctttgccga
     6841 atcgaacgga taacagtcgc ttcccgggaa accggaattt ccggcggacg accggtgtcc
     6901 cggttttgcc gtcccgtctg cgggggtcag cctgccacgt cgacgctggg ttcgccggag
     6961 gccacaccct cggcgcgcat ctcctcggcg atgcgcagag cctcctcgat cagggtctcc
     7021 acgatctgcg actccggcac ggtcttgatc acctcgccct tgacgaagat ctgccccttg
     7081 ccgttgcccg aggccacccc caggtcggcc tcacgcgcct ccccgggacc gttgaccaca
     7141 caccccatca ccgccacccg cagcggcacg tccagccctt gcagccccgc ggtgacccgg
     7201 tcagccaacg tgtagacatc cacctgcgca cgcccgcaac tgggacagga cacgatctcc
     7261 aacccgcgct ggcgcaaccc cagcgactcc aggatctgcg cgccgacctt gacctcctca
     7321 gccggcggcg ccgacagcga cacccggatg gtgtcgccga tcccctcggc caacagcgcg
     7381 ccgaacgcca ccgcagactt gatggtgccc tggaaggccg ggcccgcctc ggtcaccccc
     7441 aggtgcagcg gatagtcgca gcgctgggcc agcagccggt aggcctggac catgaccacc
     7501 gggtcgttgt gcttgaccga gatcttgatg tcgcggaaac cgtgctcctc gaacagcgag
     7561 cactcccaca gcgccgactc caccagcgcc tcgggcgtgg ccctgccgta cttggccagc
     7621 agccgcctgt ccagtgagcc ggcgttgacg ccgatacgga tcggcacccc ggcctcggac
     7681 gcggccttgg cgatctcccc gacccggtcg tcgaacttct tgatgttgcc cgggttgacc
     7741 cgcaccgccg cacagcccgc ctcgatcgcg gcgaacacgt acctgggctg gaagtggatg
     7801 tcggcgacca ccgggatctg cgacttgcgc gcgatgaccg gcaacgcctc ggcatcatcg
     7861 gcactgggca ccgccacccg cacgatctga caccccgcgg cggtcagctc cgcgatctgc
     7921 tgcagcgtgg cgttgatgtc ggcggtcacc gtggtggtca tcgactgcac cgagatcgga
     7981 gcatcgcccc ccaccgcaac gtcacccacc atgatccgcc gcgactgacg acgttcggcc
     8041 agtgccgccc cgtcgggatc gcggaccttc ggcatcccca gcggtatccc cgtcaccgtt
     8101 cctcctttcc gctccggtgc ctcagcagca accgcgccag tgcgccgtcg atcccgtcca
     8161 gggtgctgta gccgttcccg ccgtccaggt cggccactgc cccgaccacg gccagggaga
     8221 tgtcctggac ggtcaggccg cactcggaca gcacgtcgtc cctgcttccg tgaccgagga
     8281 agcgtcgggg gacaccgaac tcccgcaggg gggtggacac cccggcgtcg cgcagtgtct
     8341 gggagatcgt cgccccgatc ccgccgatcc ggctgttgtc ctcgatggtg accaccagtc
     8401 ggtgtctgcg tgccacgtcg gccaaccccg ggttgaccgg tgacacccag cgcgggtcga
     8461 tcaccgtcac accgatcccc tgggcgcgga tcccctcggc caccccgagg gcgacccgcg
     8521 ccagcgctcc caccgagacg accagcacgt ccagcgagcc ggaccgccgc agcacgtcca
     8581 tcccggcgaa ggtcatctcg gccggcaggt cctccccggt cggtcccttg gggaacctga
     8641 ccagggtggg cccctccgac caggccacgg cctcgtcgag cagttcggcc agccgcgcgc
     8701 cgtcgcgcgg cgcggcgatg cgcagtcccg gcaccacctg caggaccgac atgtcccaca
     8761 tgccgttgtg gctggggccg tcgttaccgg tgatccccga acggtccagc acgaacgtca
     8821 ccgcgcagcg gtgcagggcg acgtccatga gcacctggtc gagcgcccgg ttgacgaacg
     8881 tggagtagac ggccaccacg gggtggacac ctcccatggc cagccccgcg gccatggtca
     8941 ccgcatgctg ttccgcgatt cccacgtcga tgacacggtc ggggaagcgt tgccgcatgg
     9001 gcagcagtcc cgtcggctcc agcatggccg ccgtgatcgc cacgacgtcc gggcgctctg
     9061 ccgcgatctc gacgatccgc tccccgaaga cggaggtgaa cgagcgcccc ttcgtcgagg
     9121 gggccagcgc cttcccggtg cgcgggtcca tcggtttcac cgtgtgtccg cggtcgagtt
     9181 cgttgttctc cgtgtggacg aagccgcggc ccttctcggt cacgacgtgc acgaccaccg
     9241 gccgccccag cgcgcgggcc cggcgcagcg cctcctggag agccccgatg tcgtgtccgt
     9301 ccaccggacc cgtgtaggcc agtccgagct gctcgaagac tccgggcccg tcgtgtccgg
     9361 cgcgcagcgc actgaagtgg tccgcgactc ctcccctcgt gggtgcgtag gagcgctggt
     9421 tgtcgttgag gacgatgacc agcggccggt ccggaccgtc tgcgaggttg ttgagcgcct
     9481 cccaggccat tcccccggtc atcgcgccgt caccgatgac cgccacgacc gcccggtcgg
     9541 tgtgcccccg gtaggcgtcg gcccgggcga ggccgtccgc gtaggacagg gcggtcgagg
     9601 cgtgcgaatt ctccaccagg tcgtgctcgg actccgcccg cgaggggtag ccggacagcc
     9661 cgcccgcctg ccgcagccgg tcgaatccgg actgccgccc ggtgaggagt ttgtgcacgt
     9721 aggactggtg tccggtgtcc cagagcagac ggtcacgcgg ggactcgaag accgtgtgca
     9781 gggctatggt caactccacc acgccgaggt tgggaccgag gtgccccccg gtccgcgaaa
     9841 cgtgttcgat caggaactcg cggatctccc cggcgagttc ggtcagctcc gtgatggtca
     9901 tcccacgcag ctgcgcggga ccgtccaccg tctccaacag gctcatcttg atcactcctt
     9961 gggctgcgtg ccggtgagcc ggaagaggcg ggccgtggcc tcagcggtcc cggtaggcga
    10021 cctccctcgc catcacgacc agttcgccgc gccaggcctc gtccagttcc gcctggttga
    10081 ccgctgcgac ggcgcgtgcc acgaggccgt cgatgcggcg ttcgatctcc gttctgatgc
    10141 cgcttccgga cagcaggtcg cgtagcgcgg ggacgtccca ctccggggag tcgacgagtt
    10201 cccggacccg ggggtcccgg cggaccgcca gagccagcag cagggtcatc ttgtgctgct
    10261 ccaggtcgag gcccaccggt ttgcccgccg cctcgctccg cccgaaggcg tcgatcaggt
    10321 cgtcgcggag ctggaacgcc tcccccaggg cctcgccgta ctcttcgaag gtggcggcca
    10381 ggtcctcccg cccggcgacc agggcgccca ggagcagcgg acggtggatg ctgtagcggc
    10441 ccgacttgca caccgcgatc caccgggaca gttccgggtc gacgacgccc tcggcggcga
    10501 ccgtcacgtc caggaactgg ccgatgatga tctcggtgag cagttcgttc cacagcggcc
    10561 gggctcgcgc gggaaggctc tgggtgaggc ggtcggcgag gatgttcgcc aggtcgccgg
    10621 agaggatcgc ggtcccctcc ccgtaccggc gggcttcccc ccgccatccg cggaagcggt
    10681 gctcggcggt gtaccgggtg tggacggccg gggctccccg gcgcagatcg gaggcgtcca
    10741 gtacgtcgtc gtggatgagc gcaccggcat ggaccagttc cagtgcggcc gcgcagtcca
    10801 cgacggccct gtccccgggg tcgccgcccg ccgccaggta cccgctgacg cagaaggccg
    10861 ggcggagccg tttacccccc gccgccacca ggtcggccac ggcgtcgacc ggtaccgcgg
    10921 cccgcgggtc gacctcggcc caccgtttcc gttcggtgtc caggaggtcg gtgagtcgcg
    10981 cctccacctg ttccatgagg cggttgcgca gtgcccggac atctgcagcg gtgctcgtca
    11041 tgctctccct cccctgctca gggagctctc cgcgtcctgt cgggtgagcc tggccggcgg
    11101 ggagaagacg acgtcctcgc gcgcgacctg ttcgatctcc acgtcctcga atccgaacac
    11161 ggccagtcgt tccatgagtt cctcgacgag ggtctcgggg gcactggcgc ccgcgctcac
    11221 cccgaccgtc cgcacaccgt cgagccaggc cgggtcgagt tcgccggcct cggggaccag
    11281 gtgggcgggg acgcccatac ggcgggccac ctcgaccatc cggttggagt tgcttgagtt
    11341 gcgcgacccc accaccagca ccaggtcgct gcggggagcg atcgccttga tcgcgtcctg
    11401 ccggttctgg ctggcgtagc agatgtcgtc cgtggccggt ccacgcaggt cggtgaagcg
    11461 gctgcggagg gtgtcgatga tgtccctggt ctcgtccacc gagagggtcg tctgggtgag
    11521 gtaggcgacg ggggtgtcgg cgggcaggtc gagctgccgg gcgtcctcga ccgtctcgat
    11581 gatgaccgtc cggtcgggcg cgtgtccgta ggtgccttcc acctcctcgt ggtcggcgtg
    11641 tcctaccagc agcagggtgc gctcctcccg ggagaagcgc agcgcttcct ggtggacctt
    11701 ggacaccagg gggcaggtgg cgtcgatcac gtccaaccgg cggtcctccg cgttccggcg
    11761 tacctggggg gagaccccgt gtgccgagaa cacgcacacc gcgccctcag ggacctcttc
    11821 ctccgagtcg acgaacaccg cgccccgctg tctcagctgt cgcacgacgt aatggttgtg
    11881 cacgatctcc ttgcgcacgt agacaggggc gccgtggcgt tcgagcgcca gctcgatgat
    11941 ggatatcgcc cgtcgcaccc ctgcgcagaa acttcggggc tcggccagga gcaccttctt
    12001 cgcaggaagc atctccgctt caccttcaac ctagatggat gtccgctgca ttcccgcacg
    12061 gattccggct ccttgactgt gcgattccgg ttacctcgaa gtcaaacaat ccagggcaca
    12121 cagacaggaa gtagccatgt gtagccacac ccctgccaac agattattgc ctttgatttg
    12181 ctacttacca agcaaacccc taattcctat tctttctcca gtccagagaa agccgggcct
    12241 ttttgtccac caggtgtgcc agccgccaca ccgaaccggg ggcagcatga ataccatcac
    12301 ccaagaagca gtcggcgacc tgcagaaaca tgctggagca accactccgg tccagccgcg
    12361 caaatattcg ggaaatctct ccgagccagt attcgaagaa ctttccgaaa cactgttcgc
    12421 gtcacttcgg cgcagcgacc agcgccgcag ggggctcgat tatctgcgtg gcctgctgcg
    12481 cacccccgga cgcaagtcga ttcggaacat ggctgctctg ctgggcggta gcgggacggg
    12541 ccagagcctg caccacttca tctgcaactc cacctgggaa tggtcgccgg tccgggccgc
    12601 actcgccggc tacctggcgc gtgtcgcccc gccgctggcc tgggtggtgc gtccgatggt
    12661 cattcccaag accggtcagc actccgtcgg agtgggccgg tacttctccc cggtggacgg
    12721 ccaggtgttg aacgcacagc aggccgtcgg cctctgggcc gtctcggaca gaaccggcgt
    12781 cccactcaac tggcacctgc gccttcccga gcagtggcac gacgtctccg actgcggtgt
    12841 cccctccccc cgtcccgcac ctcccaggcc actgggtgac tgcgcggtgg agatgtgccg
    12901 ggaggccctg gccgactggg gtctgccgcc ccggcccgtg gtggtggaca tcggcgaggc
    12961 gaaccccctg ccgaccctgc ggcggctcac cgccgagggg ctcagctcga tggtccgagt
    13021 ccccggagac ctgccgctga ccgtggtcga cgaggcactc accgggcacc gcggcaacat
    13081 actgccggcc gcccagatca tgcgtgccgc tcgggaactc cgcaggccgg tgacgtggcg
    13141 ggagcgcggt ccacgcccgg tccggcggac cgcgctggtc gccgcggtgc gggtccgcag
    13201 ccatcccgac tgcggcaggg acaccgtact cgtcgggatc ggcgggatcg gcgcggagtg
    13261 gctcaccgaa ctgtgggcga cctccctgcc cgcgtcgtgg gccgccaccg ccgtcccctg
    13321 gatgagcgga ttcgtccggg ccgtcgaccg ggacttcgag acgatctccg agcacgtcgg
    13381 aatacgcgac tacgtgggcc gatcgttcag cggatggcac cgccacgtca ccctcgcatc
    13441 ggccgcgcac gccgtcgtcg cgctgtcctc aacgccggcg gacctggtgg gccatgcctc
    13501 ctgaccgccc cggccgcccc gggggcgcgg ccgaccgccg tccgtcccgg agccgtgtga
    13561 cctcccgggc ggcccttccc cgccccggac ggagcagggc cccgcggccc ccggccggca
    13621 ccgctgcgct cacccttttc ccctcacacg tggaggagca agtgtactcc ggtcttccgg
    13681 tcacccgcct gggaccagcc ccgcagcagc ccgactgggc cgacgacccc cgcctcccgg
    13741 cggcacgccg agaactcgcc ctgcttcctc ccctggtccg cccggaggat gtggaccggc
    13801 tccgcctcct cctcgcccgg gtggccgcag gggaggctct ggtcgtcctc gccggggact
    13861 gcgccgagga cccggcggag agcaccgccg ccgacgtggc ggccaagacc ggtctggtcg
    13921 agaccctggc ccgcatggtc ggctccgcct cgggcaagcc cgtcgtccgc gccgcacgca
    13981 tcgccgggca gttcggcaag ccgcgctcgc gctccaccga gacggtcggc ggccgggagc
    14041 tccccgtcta ccgcggacac ctggtcaaca gccccgaacc ggaccccgaa ctgcgcaggc
    14101 ccgacccgct ccggctggtc gcctgctatc gggccgccgc cgagatcatg gggcacctgg
    14161 gctggcgtcc ggacctcccg cgccacgacg ccgacgcccc cgtgtggacc agccacgagg
    14221 cgctgctgct cgactacgag gtcccgctgc tgcgccggac cggcgacgga cgcgtcctgc
    14281 tcgcctccac gcactggccg tgggtgggcg agcgcacccg gagcgcggac ggcgcgcaca
    14341 tcgctctgct ctccggcatc gccaaccctg tggcctgcaa ggtgggcccc acgacggaga
    14401 ccgacgaact gctggaggtc tgcgagcggc tggacccgcg gcgggtgccg gggaggctca
    14461 ccctcatcgc ccgcatgggg gccggcgtcg tggcccgcag gcttcccccg ctcgtcgagg
    14521 ccgtccgcgc cgcagggcat ccggtggtct ggctcaccga ccccatgcac ggcaacaccg
    14581 tgaggacccc gtccggcctc aagacccgct acgtggaagc gatcgtccgc gaggtccagg
    14641 agttccactc ggcggtgcgg tcagccggcg gtgtccccgg agggctccac ctggaggcca
    14701 ccccgcagga cgtcaccgag tgcgtccccg accgcttcca cgtcgaccgg gtccccgcca
    14761 agtacaccag cctctgcgac ccgcggctga acccggacca ggccgtcgcc gtggcggctg
    14821 cctggctgca ctgacccccg gccgtccggg tgggaggcgt ccagtaccga atccgtccag
    14881 agaggagcag cacatggagg acagtgtcgc cctggtgacc ggggccgcca gcggaatcgg
    14941 cgcggccgtc gccagggcac tgggcgagcg aggcgccacg gtggccgccg tcgaccggga
    15001 cgccgagcag ttacgcaccc tggtggacaa gctcagagcg gacggggcac gtgtcgaggc
    15061 gttcgccgcc gatgtgagcc tggcctccga ggtcgagggg gtggtgcggg aggtggaacg
    15121 gaccctgggc cccctgcact ccctggtcaa cgctgctgga gtactccgtc tcggcggggt
    15181 gcgggacctc accgacgacg actggtccgc caccttcgcg gtcaacgcca ccggggtgtt
    15241 ccacacctcc cgtgccgccg cgcgccggat ggtcccgcgc cggcgcggag ccatcgtcac
    15301 cgtggcctcc aacgccgcgg ggacggcacg catgggcatg gccgcctacg cggcctccaa
    15361 ggccgccgcg acggcgttca cccggtgtct cggtctggaa ctcgccgcat acggcatccg
    15421 gtgcaacgtc gtcgcgccgg gatcgaccga caccccgatg ctgcggtcca tgtggcacga
    15481 cgcgtccggc ccggccgcga cgctccgagg agacccggaa gcgtaccgcg tgggtattcc
    15541 gctgcagcgg ctggcccagc ccgccgacat cgccgactcg gtgctgttcc tgctctccga
    15601 ccaggccgcg cacatcacca tgcacaccct gacggtggac ggaggcgcca ctctcggctg
    15661 ctagcccttg tccggcgaac cgccgtgggt ccgccaccgc cggggcacca ccgcgtcggc
    15721 gcccgcgggc cgcagacgaa ggcctgcacc gcgcaccgac gccgtcccgg acagcgaccc
    15781 gtcgttccgg gccccaccag acagacccag tcccgaccaa gcggaggacg accatgacag
    15841 gaatcccacc catccggccc taccccctgc cggaagcgga cggcctgccc gccaacaccg
    15901 cgtgctggac cgtcgacccg gaccgcgcgg tgctgctcgt gcacgacatg cagcgtttct
    15961 tcctccgtcc tttcgactcc gccggagaac cgtgccggac actgctgcgc aactgcgtgg
    16021 cgctgcgtga gcggtgcgcc gcactcggcg tcccggtcgc ctacaccaca cagcccggga
    16081 acatgaccga cgagcagcgc ggcctgctga aggacttctg ggggcccggc atgagcgccg
    16141 tcccccagga ccgcgcggtg gtggagccgc tggccccggc ccccggcgac tgggtgctca
    16201 ccaagtggcg ctacagcgcc tttcaccgtt ccgacctgct ggaactgatg cgtgcccacc
    16261 accgcgacca actggtcgtc tgcggcgtgt acgcccatgt cggcgttctg atgaccgcgg
    16321 tggacgcctt cacccacgac atccggccgt tcctgcccgc ggacgcggtg gccgacttct
    16381 ccgcggagta ccaccacatg gccctggagt acgccgccca gcgctgtgcg gtggtcacct
    16441 ccaccgcagc cctcctggcc gccctcggct cggcggtcct ggactccccg gagttggcgg
    16501 tggaggcgag gacatgagcg gcggagggac cggaaacgct gacctgctcg gcagcatcct
    16561 ggcagcgcct cccccggcgt tcgccctgct gtaccgcccg gagacgagct gtcccgaggt
    16621 cgtggacgta ctcgtcggcg aggtgtccac gcccgaggtg ctggccgctc tcccgctgcc
    16681 ccctcgcgac cgccgtaccg gccgcgccgg acacgacgtg ctcgccgtca tcccctaccg
    16741 gcagctcacc gagcgcgccc tcccgtgcaa cgacgacggc gcgccgctga tcgcgatgac
    16801 cgtcaccgcg caggagaccg tggcactcgc ggacctcctg ggccggatcc ccgactgggg
    16861 gatccgggtg gcgaacggac gcttcgacgt gagcgacgag gcctacgccg ccgcggtgga
    16921 gcggatcatc gccgaggaga tcgggcaggg ggagggcgcc aacttcgtcc tcggacgctc
    16981 ctacctcgcc gaaatcgccg actacacgcc gcacagcgcg ctcaccctgt tccgcaggct
    17041 cctggagcag gagtccggcg ccagttggac gttcgtcgtc cacgccgcgg gccgcacctt
    17101 cgtcggcgcc acacccgagc ggcacatcag cctgcgcggg ggcgtcgccg tgatgaaccc
    17161 gatcagcggc acctaccgct atccgccgtc gggccccgac ctcgccgagg tgatgctctt
    17221 cctctcggac cgcaaggaag ccgacgagct gtacatggtc gtcgacgagg aactcaagat
    17281 gatggcccgg atctgcaact ccgggatccg ggtggacggc ccccgcctca aggagatggc
    17341 ccggctggcg cacaccgagt actacatcaa gggccacacc ggccgcgacc cgcgggagat
    17401 cctgcgtgag acgatgttcg ccccgaccgt caccggaagc ccgctggaga gcgcgttccg
    17461 ggtcatcagc cgccacgagc cccggggccg gggctactac agcggcgcac tcgccctcat
    17521 cggccatgac gagcggggtg accgcaccct cgactccgcc atcctcatcc gtaccgccga
    17581 aatcgccccg gacggccgga tgcgcatcgg tgtgggcgcc accctcgtcc gccactccga
    17641 cccggccgcc gaggcagccg agaccagggc caaggcggcg ggtctgctcg ccgctctgga
    17701 gaccgcgcgg ccgacgcggc tggccgacca cccggcggtc cgcacagccc tggacgagcg
    17761 caacatgcac ctctccagtt tctggctgga cgggaacgcc gaatccacgc ccgtaccgga
    17821 actcgccggc ctgtgcgccc tggtgatcga cgccgaggac gcgttcacct cgatgctggc
    17881 gcaccagctc cggtccatcg gcctcgccgt cacggtccgc cgattcgacg aaccgtactc
    17941 cttcgacgag caccacctga tagtaatggg cccgggtccg ggcgatccgc gcgacagctc
    18001 acatcccaag atcgcgaggt tggaggcagc gatacgtacc ctcctcgccg aacggagacc
    18061 ctttctcgcg gtctgtctga gccaccaggt gctgagccgc acgctcggtt tcgccctgca
    18121 ccgacgcgca gtccccaacc agggggtcca gcaccgtatc gacctgttcg gccaccggga
    18181 gcgggtcggt ttctacaact ccttcgccgc cgtcagcagt gaggacaagg tggagtgcga
    18241 agggaccgga accgtcgagg tgagccgcga cgcggagacg ggtgagatcc acgccctgcg
    18301 cggtcccggg ttcgcctccc tgcagttcca tgccgagtcg gtactcacgc acgacggtgt
    18361 gcgtctcctc gcccggaccg tccgggagat cctcggccgg tgagaccggc ctgccccaac
    18421 caccatcgac aagacaggag taaggaaccg tgacgaacac gccgctgcgg ctcgccgtgg
    18481 tcatcggcag catccgcgag ggccgtttcg gtccgaccgt cgcacagtgg atcaccgagg
    18541 aggcgcgctc cttcggccag ttcgacgtcg acgtcgtcga tctggccgat gccggactcc
    18601 cgatgcggat caccgacacc gcgcctccgg aggtggaggc gctgcggccg cgcctggccg
    18661 cggccgacgc cttcatcatg gtggtccccg agtacaaccg gggctacccg gcctccctga
    18721 agaccctgat cgactggtac atcgaggagt ggcaggccaa gccggtcggt ttcgtgtcct
    18781 acggggggcg aggcggagcg ctgcggtccg tggaccacgt gagcgcggtg ctcagcgacc
    18841 tgcacgcggt accgctgcgc gacacggtca gcttccatga cgcgtgggac aagttcgacg
    18901 cgtccggtcg ccccgtcgac cgggagggcg cggaggcggc ggccaagatc ctgctggacc
    18961 gcctgctgtg gtgggggtcc gcgctgcgct ccgcacgact tgagcacccg tacaaccgct
    19021 gaccgggtgc cggaccggaa gcacaccggc ccggcacccc ggcatccgct cctccgggtt
    19081 cacaggacgg cggcaccggt gttgaggcag gcgagcagag tgcgggcctg gacgttgagg
    19141 tagtggccgt gccgcaccag tgcccgcaac tggccggggg tcacccagcg gtaaccgggc
    19201 ggcggggaca gcggagcctc gtcctcgtcc gcctccacca ccatgacccg gttctccgcg
    19261 ccgcggaagc gtccgccctc ctccgagtgc accgcctcgt agcggacgcg cccgggcggg
    19321 gcggacagca ccacgtcgag gaaggggggc ctcctcccgg ggggcaggtg ggcgtagttg
    19381 cccggatcgc actgcaccgt cggcgccagt tcgaccacgc cgggaagccc tccctccacc
    19441 cgggcgtgca cgagtacgtg cgggacaccg ccgagacggc gggtgaggaa cgcgatgacg
    19501 ccgcgccggt acggctcgaa cagcggctgt gtccacctgc ccacctcgcg ggtgcccgcc
    19561 tccaccgcca cggcgaccac ccggaagtac cggtcctccc ggtggcggat ggcgtactcc
    19621 tcacgctccc agtccggcac ggaggccagg ggcacgcgcc gggccgtcac cccgtacctg
    19681 gtccgctccc cggtgagcca tgacagcagc tcggtgtcgg tgtgcagggc ctcggtcccg
    19741 tcttcgggca ccggagcgca ggacaggacc gtgcgcgagt ccatgttcac caggttgtcg
    19801 cggcgcagca gtcggccgat ctgcccgagc gtcagccagc ggaagtcctc gtgcggggcg
    19861 acgtcctcgg tcacctcgac gatcatgttc cggttgctct ttcggtagaa ccacgcgccg
    19921 tgctccgact gcaggacgtc gaccaggacc cggccccggc cgggctggac gaagtagtcg
    19981 atgtggtgga ccttccttcc ccggtgcgcc cccgtgtagt tgctgtacgt ggcctgcacg
    20041 gtcggggaga gctggaccag gttggggttg cccggctcca tcttggcctg catcaggaag
    20101 tgcagcaccc cgtcgaactc cttcgccagg atgccgagga tgccgacctc cggctggtgg
    20161 atgacgggct ggcaccattc ggggaacggc ccgttcctga ccgtgacgtg caggccttcg
    20221 acggtgaaga aacgtccgct gtggtgcgcc aggttcccgg tccgttcgtc gaaccgccac
    20281 ccgtcgagcc cggccagggg gatcggctcc acccggaagc cttccgaggc ggcgcgtccg
    20341 gcgacccagt ccgcggtctc ccgcacggtc ctctcgtccc cccgggccgc caccgaacgg
    20401 gccatccgct cagccgtccc cggttcccag cggggacgcg gcagcacgga ggggttccgc
    20461 tggactgcca cggtcaccct ccggcggtcg gcgacgtctc gaaggccgcg atccgctcgc
    20521 cccggttccg tccaccgccg tatttgaccg ctttccacca gtcgacgttc tcgcggtacc
    20581 aggcgaccgt gtcggccagt ccgcgttcga aggggatctc cggctcgtag cccagctctt
    20641 cccggatctt ggtcccgtcg agggcgtacc gccggtcgtg cccgtcgcgg tcggccaccc
    20701 actggatcgc cgtacggtcc gcaccgcaca gttcgagcag ccgctcggtg atttcgaggt
    20761 tggtccgctc gtccccgccc ccgacgttgt agacctctcc cgccttcccc ttcgtgagga
    20821 tgaggtggac ggcccggcag tggtcgtcga cgtgcagcca ctcacggacg ttcaacccgt
    20881 cgccgtacag cgggaccggc tccttctcca gcaggttcgt gacgaagcgc gggatgagct
    20941 tctccgggtg ctggtagggc ccgtagttgt tggagcagcg gctgatggag acgtcgaggc
    21001 cgtgcgtccg ccagaaggcg cggaccacca ggtcggaggc t
//
