LOCUS       NZ_CP051627            23944 bp    DNA     circular CON 21-APR-2024
DEFINITION  Thermobifida alba strain DSM 43795 chromosome, complete genome.
ACCESSION   NZ_CP051627
VERSION     NZ_CP051627.1
KEYWORDS    RefSeq.
SOURCE      Thermobifida alba
  ORGANISM  Thermobifida alba
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsaceae; Thermobifida.
REFERENCE   1  (bases 1 to 4903256)
  AUTHORS   Luzics,S., Horvath,B., Nagy,I., Toth,A., Nagy,I. and Kukolya,J.
  TITLE     Thermobifida alba genome sequencing and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4903256)
  AUTHORS   Luzics,S., Horvath,B., Nagy,I., Toth,A., Nagy,I. and Kukolya,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2020) NGS Platform, Seqomics Ltd., Vallakozok u.
            7., Morahalom 6782, Hungary
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: RA v. v0.2.1; CLC Genomics Workbench v. 11.0.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 331.0x
            Sequencing Technology             :: PacBio Sequel; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023208015.1-RS_2024_04_21
            Annotation Date                   :: 04/21/2024 13:45:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,356
            CDSs (total)                      :: 4,290
            Genes (coding)                    :: 4,246
            CDSs (with protein)               :: 4,246
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 44
            CDSs (without protein)            :: 44
            Pseudo Genes (ambiguous residues) :: 0 of 44
            Pseudo Genes (frameshifted)       :: 10 of 44
            Pseudo Genes (incomplete)         :: 35 of 44
            Pseudo Genes (internal stop)      :: 3 of 44
            Pseudo Genes (multiple problems)  :: 4 of 44
            CRISPR Arrays                     :: 12
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:37:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2319276
            Orig. end                         :: 2343220
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP051627.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23944
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="7"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..23944
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23944
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13944](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13944
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(550..1398)
                     /locus_tag="FOF52_RS10265"
                     /old_locus_tag="FOF52_10190"
     CDS             complement(550..1398)
                     /EC_number="1.1.1.25"
                     /GO_function="GO:0004764 - shikimate 3-dehydrogenase
                     (NADP+) activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011292490.1"
                     /locus_tag="FOF52_RS10265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_10190"
                     /product="shikimate dehydrogenase"
                     /protein_id="WP_248593592.1"
                     /transl_table=11
                     /translation="MKRAAVLGSPIAHSLSPVLHTAGYTALGIADRWHYGRHECDERGL
                     AAFLDGCDDSWAGLSLTMPLKKVALTLADEVEETAVEVGGANTIVFRDGRRHAYNTDVA
                     GITEALREAGVRRLDTVTILGAGATAASALAAVRRLGATEPGAVTVLARDLARTGDLAA
                     AAERMSAEVALAPLADIDEHLRVDLVVSTVPAGAADRWAPAVAASSAAVFDVVYAPWPT
                     VLGAAAAGAGSTVIGGFPMLLHQAAAQLTLMTGRPAPVEAMRVAGEAELARRAAGNNVE
                     P"
     gene            complement(1455..3518)
                     /gene="mltG"
                     /locus_tag="FOF52_RS10270"
                     /old_locus_tag="FOF52_10195"
     CDS             complement(1455..3518)
                     /GO_function="GO:0008932 - lytic endotransglycosylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="mltG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011292491.1"
                     /locus_tag="FOF52_RS10270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_10195"
                     /product="endolytic transglycosylase MltG"
                     /protein_id="WP_248593593.1"
                     /transl_table=11
                     /translation="MNGNDRYDDYPRRARRPDPLTDPWPLHREAEAPRTGASAVDYGGR
                     GYRDERGVGRRRRVDTPRADSTAWPSPRAAQTAAPVSGTETDRPAEAERPRGRRRRPGP
                     ADTGSFTLPPTEAEALLERPRGRRRKPDSEEWPSTPRPTPDRAASGPGAETVEAWGTAG
                     HGRPTVAPDTSVSRGRRAGPEDGAAHPADRGAPRLRDGLRHQEAWSDDPLRVPREHRPP
                     ADAEDGAGRAGSRRRVLDEGDWDAPPRGRRARPPAPDDEDAAPRSRRRAHAAAPPAVDE
                     EPPRRERRTRATTPDEEDPDSFALPFDEDDDEEPPQRSRSGRRGGRRASGRRASSRRKR
                     KKSKAALVSAVLVLTLFVVSVGAGGYLLLRTYVIPPDYSGEGTGEVSIVIEEGDTGTAI
                     AEKLHEAGVIASVRAFTNEIRFSEANFVPGTYQLRMQMSAEAAIALLLDPGSRIALNVT
                     IPEGLRSGQILERLAEQTGIPLEEFQAAYEDHGALGLPEYATQGPEGYLFPETYEFDSN
                     ASAAEILRKMVAQYRKVATEVELERRAEEAGFDPNEIMAIAAIVQAESGKVEDMGKIAR
                     VVYNRLADGMYLKMDSTCFYALGEYGIAINLEQQDRCRGDETGYDTYFHEGLPVGPIVS
                     PGKDAIEAALAPEEGPWLFFVATDPENGVTKFTDSEAEFWELVEEFNQSQAN"
     gene            complement(3515..3994)
                     /gene="ruvX"
                     /locus_tag="FOF52_RS10275"
                     /old_locus_tag="FOF52_10200"
     CDS             complement(3515..3994)
                     /EC_number="3.1.21.10"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0008150 - biological_process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ruvX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011292492.1"
                     /locus_tag="FOF52_RS10275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_10200"
                     /product="Holliday junction resolvase RuvX"
                     /protein_id="WP_248593594.1"
                     /transl_table=11
                     /translation="MRTGVRLAVDPGTARIGVARSDPSGILATPVETIRRGPGDLDRIA
                     ALVLEYEAREVIVGYPASLSGAEGRAARAARAFARTLARKLAPVPVRLVDERLTTVTAQ
                     QQLQTGASYGRRGARGGRARRSVIDQAAATVLLQNALDTERRTQLPPGELVEGTP"
     gene            complement(4080..6749)
                     /gene="alaS"
                     /locus_tag="FOF52_RS10280"
                     /old_locus_tag="FOF52_10205"
     CDS             complement(4080..6749)
                     /EC_number="6.1.1.7"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004813 - alanine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006419 - alanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="alaS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011292493.1"
                     /locus_tag="FOF52_RS10280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_10205"
                     /product="alanine--tRNA ligase"
                     /protein_id="WP_248593595.1"
                     /transl_table=11
                     /translation="METAEIARRFLAFFEKNGHTVVPSASLVAEDPTLLLVNAGMVPFK
                     PYFLGQRTPPYTRATSAQKCVRTIDIDEVGKTSRHASFFQMLGNFSFGDYFKEKAIPFA
                     WELLTSSVADGGFGFDPERLWVTVYLDDDEAEAIWREKVGLPAERIQRRGKADNFWSMG
                     VPGPCGPCSEIYFDRGPDYGAEGGPVADENRYLEVWNLVFMQFERGEGSGKEDYPILGE
                     LPSKNIDTGMGLERMAAILQGVDNIYETDTLGRILRRAAELTGVTYGENERSDVSLRVV
                     ADHVRTATMLVADGVKPGNEKRGYVLRRILRRSIRNLRLLSGDESFHLHDLTGVAIDAM
                     GDQYPELRADADQIHSVIDAEEKNFADTLRAGTTLFNRVVERTRKSGGTEFSGADAFQL
                     HDTYGFPIDLTLEMASEQGLKVDEDTFHRLMQRQREAAKRDAKAKKLGNADVSVYARLL
                     EAGGPTDFLGYTDTEGEARVLGVIVDGEATGAARKGDRVELVLDRTPFYAESGGQLADK
                     GTIAVDGRGVVDVEDVQKPIKGLFVHRGTVRDGEVVVDDTVHAAIDTDRRASVSRSHSA
                     THLIHSALRNALGPSAGQAGSENQPGRLRFDFTANKPLDAAEIAHVEEEVNEVLARNIE
                     VQYMETTLDKALQMGALAMFGEKYGDRVRVVDMTDYSRELCGGTHVGATGQLGLVKVLG
                     ESSVGSGVRRVEALVGLDALRRVSTESALVGQLSEQLKAPREELPQRIDAVISRLRAAE
                     KEIERLRAAQVLQAAGELAAGARDLGGTRVVTHRVADGTTADDMRKLALDVRGRLGEDA
                     PAVVVVAGVPGDRPVVVVAANKEAQGRGLKAGELVGVAARALGGGGGGRPDIAQGGGSD
                     AGAVETALRAVEQRVAGS"
     misc_feature    complement(6701..6714)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.84"
                     /tool="antismash"
     misc_feature    6762..6780
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.92"
                     /tool="antismash"
     gene            complement(7179..7847)
                     /locus_tag="FOF52_RS10285"
                     /old_locus_tag="FOF52_10210"
     CDS             complement(7179..7847)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017582231.1"
                     /locus_tag="FOF52_RS10285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_10210"
                     /product="YdcF family protein"
                     /protein_id="WP_248593596.1"
                     /transl_table=11
                     /translation="MSNTPPTISDEHYRLAERIWDYHRMGHELRPVDVAVVLGCHDLGV
                     AACAAKLYQAGFFARMVLTGGNSPSTAEVFPRGEAVHYREHVLDLGVPDEAVLVEPRAA
                     NTGQNITLSRQLLAEAGLAPATVMLVTMPYMQRRAYATTRRVWPEVTVVCASEPVGFRD
                     YLAGIGDDRLVIDTMVGDLQRVIEYPDRGFAVEQHVPDDVHAAYQALVDAGFTSRLIGA
                     "
     gene            8229..9491
                     /gene="fxlM"
                     /locus_tag="FOF52_RS10290"
                     /old_locus_tag="FOF52_10215"
     CDS             8229..9491
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014910209.1"
                     /locus_tag="FOF52_RS10290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_10215"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_248593597.1"
                     /sec_met_domain="PCMT (E-value: 3.6e-39, bitscore: 132.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSPLPPTPEQARMAMVDAMAAERARLGAQPLPRAVEEALRAVPR
                     EAFLPGLPLTEAYDPHQAVVTRRDEERGVALSSVSAPTIVATMLERADLRPGHRVLEVG
                     SGGYNAALIRRLVGVDGQVVSIDIDPEVVTRAERCLKSIGVDDVHLAVGDGAHGFAARA
                     PFDRIIVTAGAWDLPPAWEQQLAEDGVLVVPMRIRGLTRCLTLRRAPEEGCWEAVAVDM
                     CGFVRMRGRDEHWEAMPCLHDEDGCQVALRLEDGPEVEEKALREALACEPVTVWSNVEV
                     GAEEPTDSQDLYLASVADRWAQLTAERGAIKAGLVSPISRLGTPALISAEGTGFAYRTL
                     RRCPGRADRWEFGAVGHGPHARATAEHLAHLIGEWDRDHRRGPGPRITLFPATTPDDRL
                     PGGRVVDKRHTRTVLTWTITP"
     misc_feature    9514..9529
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     gene            9515..9715
                     /gene="fxlA"
                     /locus_tag="FOF52_RS10295"
                     /old_locus_tag="FOF52_10220"
     CDS             9515..9715
                     /codon_start=1
                     /gene="fxlA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019608870.1"
                     /locus_tag="FOF52_RS10295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_10220"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_068757968.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 5.7e-11, bitscore:
                     40.2, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTLTVSDTPDGMVPVSRDRHPAGDLFDLDLRVHVPQQGEPLWSM
                     TNDGCGKTCETACTPSCTDNG"
     CDS_motif       9515..9640
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSTLTVSDTPDGMVPVSRDRHPAGDLFDLDLRVHVPQQGEPL"
                     /locus_tag="FOF52_RS10295_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9641..9715
                     /prepeptide="core"
                     /locus_tag="FOF52_RS10295_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-0.90"
                     /molecular_weight="2356.5"
                     /monoisotopic_mass="2354.9"
                     /core_sequence="WSMTNDGCGKTCETACTPSCTDNG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSTLTVSDTPDGMVPVSRDRHPAGDLFDLDLRVHVPQQGEP
                     L"
                     /leader_location="[9514:9640](+)"
                     /alternative_weights="2374.6"
                     /alternative_weights="2392.6"
                     /alternative_weights="2410.6"
     gene            10001..12727
                     /locus_tag="FOF52_RS10300"
                     /old_locus_tag="FOF52_10225"
     CDS             10001..12727
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="FOF52_RS10300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_10225"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_282574021.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 7.5e-124,
                     bitscore: 412.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.9e-17,
                     bitscore: 60.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.1e-22, bitscore:
                     76.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSRRRRSAGLLSPLMRYLLRYGGRPTPYGLFAGVAPLTSGGRTR
                     VRWGEHHRETAQPASAWLAVRARHHPVPGSFTTVVAASTARVRGDRLVLSHKPGADDPR
                     QAAEVSVRLTPAVALVVENARTPVPLAELLRMLGDSYPDADPREAAALVDSLLEHRILI
                     GSQRPPVWHPRPLAHLADHDPGLKAASELLECHNDPGTPAGERPGLRGQILRRLPDTDT
                     ETLPRLAVDTRLDVDLVLPHQVAHETARAAGVLATLAPHPTGHPAWIDYHTRCLETYGQ
                     GTVVGLLDLTGPAGLGFPHGYRGSRLSEPAPDRGNLERSRILVAALHTAALQGLFEIDL
                     QDPAWQHLSGEQTVHPPVHVELRAQLHAATPEAVDAGDFRLWITAVSRGVGTLTGRFAH
                     LDGMVPADLDRALPTLTERAVTVQVLAPPMADTAAHVARSPVVAAHVLVIDEHPPPAPG
                     IEVINPREVGVRVDADHLRLLHLPTERVIEPFLASALEPHHYTHPLARFVTELPRARTL
                     PSLGFTWPSAASDCVFLPRLRSGRTVAAPAQWRVTAEDLSTVRSHPPLPQRVQLVEGER
                     CLPLDLSRSAHRHLLETHLARYGTAVLTEAPDEEAFGWCGGRPHELVVPLRRTAAPVPA
                     PQLSAVTAVSARPQSPPVADPPGTGPWLSVHLYTGPDLCLLILDRLPELWDLLGGPVDF
                     WFVRYRDHDGPHLRLRLRTETSPAEPTAAVGTWARSLHACGLLHSLSLHTYRPETARYG
                     HGPALAAAEAFFVADSRAAQTQLASADHDPTRTRALAAASLLRLAAAADTGTTWLLDHL
                     PRPADPVDRAARALAARILTRPGSFSPPLAAAWADRDQALTAYLACLPRPRQVLPSLFH
                     MHHNRVRGPDRDDEQRVQALARAVALTRRHTRTAGKP"
     aSDomain        10232..10507
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FOF52_RS10300_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.50E-19"
                     /identifier="RREFam001.1"
                     /label="FOF52_RS10300"
                     /locus_tag="FOF52_RS10300"
                     /protein_end="169"
                     /protein_start="77"
                     /score="60.7"
                     /tool="antismash"
                     /translation="TVVAASTARVRGDRLVLSHKPGADDPRQAAEVSVRLTPAVALVVE
                     NARTPVPLAELLRMLGDSYPDADPREAAALVDSLLEHRILIGSQRPP"
     misc_feature    12383..12385
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12727..13944
                     /locus_tag="FOF52_RS10305"
                     /old_locus_tag="FOF52_10230"
     CDS             12727..13944
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012854951.1"
                     /locus_tag="FOF52_RS10305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_10230"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_248593599.1"
                     /sec_met_domain="LANC_like (E-value: 2e-42, bitscore:
                     143.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIRAGRAAAAAAARLTEPAAVPLGAPPQSLAAGALGIALVHIER
                     ARGGDEAAWRSAHAWLQAAARDGVDATDRARLFHGAPALAAVLVCADDESGRYATARST
                     MTHHVRAVAHRRLDAAFARMDRGALPVFGEYDLLSGLTGIGAVLLRTDPASSALERVLS
                     YLVRLTEPVRVDGCPLPGWWVGHAPHQGDRTGFAGGHANLGMAHGITGPLALLSLALQQ
                     GAIVTGQVGAIVRICAWLDSWQQDAPAGAWWPRWITRDEHRARRCTQPGPLRPSWCYGT
                     PAIARAQQLAALATGDLVRQRRAEQVLADCLNDPAQLGQIIGPGLCHGWAGVFQTVWRT
                     ARDSHTPVLADCLPRLAEHLITCGASRRGGEAGFLDGDAGLALALRTAARPEPPASDWD
                     ACLLIR"
     gene            complement(14049..14312)
                     /locus_tag="FOF52_RS10310"
                     /old_locus_tag="FOF52_10235"
     CDS             complement(14049..14312)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017624644.1"
                     /locus_tag="FOF52_RS10310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_10235"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_083948316.1"
                     /transl_table=11
                     /translation="MNQDDTLVLDWRISSYSPSGGKSCVEVGWHISSYSANGGGRCVEA
                     GPLLDTPARVAVRDSTQRGLGFLTFPAAEWHAFLRAATSGAL"
     gene            complement(14309..15160)
                     /locus_tag="FOF52_RS10315"
                     /old_locus_tag="FOF52_10240"
     CDS             complement(14309..15160)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.3"
                     /locus_tag="FOF52_RS10315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_10240"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_068757964.1"
                     /transl_table=11
                     /translation="MSKRRPTLRAQWLGKMLKELREQNGLKLTDSAEYLQRSFSAISKF
                     ESGALPIREPEVRALMDLYGVEGERQRAALIQLSREVSKTGWWEKYSDDITDWFVDYVW
                     LESRARHIRAYEVTPVNGLLQTREYAEAWMRAVNPHDSAAQIERGVELRMARQKILRGE
                     KAVELEVLLDEAALRRIVGGRDVMREQLQHLLVCGKQSNIEIRVLPYSAGAHASPDGGF
                     TLLHLEDPFPLVAYTVGVAGGVYLESHEAERVDVLYNRLRESSLSPEESAKLIVELQKE
                     MR"
     misc_feature    complement(15177..15191)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.74"
                     /tool="antismash"
     misc_feature    15188..15201
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.68"
                     /tool="antismash"
     misc_feature    15189..15202
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.53"
                     /tool="antismash"
     misc_feature    complement(15190..15203)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.83"
                     /tool="antismash"
     misc_feature    15317..15326
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.29"
                     /tool="antismash"
     gene            15378..15737
                     /locus_tag="FOF52_RS10320"
                     /old_locus_tag="FOF52_10245"
     CDS             15378..15737
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FOF52_RS10320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FOF52_10245"
                     /product="hypothetical protein"
                     /protein_id="WP_248593600.1"
                     /transl_table=11
                     /translation="MTDVHALPTPIVSQAWQEVDTSIDTETPRLLCEEQFERYTATVAA
                     LREAAGLTVHHSAEDPASLRVCHPRTGYTVELDMREDRSAEWSLDAGDEIPENTPAVRL
                     AATITGILNGAPPRG"
     gene            complement(15816..16064)
                     /locus_tag="FOF52_RS10325"
                     /old_locus_tag="FOF52_10250"
     CDS             complement(15816..16064)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011292495.1"
                     /locus_tag="FOF52_RS10325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_10250"
                     /product="DUF6167 family protein"
                     /protein_id="WP_248593601.1"
                     /transl_table=11
                     /translation="MIGRTVSFVAGALVGGYVVYRATRAARAWSPGGIADRVERRVASY
                     REALRELNEDVAEAARAHEEELLRRYAADPYPELPRR"
     gene            complement(16061..16453)
                     /locus_tag="FOF52_RS10330"
                     /old_locus_tag="FOF52_10255"
     CDS             complement(16061..16453)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017625757.1"
                     /locus_tag="FOF52_RS10330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_10255"
                     /product="DUF948 domain-containing protein"
                     /protein_id="WP_248593602.1"
                     /transl_table=11
                     /translation="MLTGGELAALVAAVVWAVVAVFLCVALIRLARLLAEATRAVSEFR
                     EHTAPLLDDLAATVERANGSLDRVEEITANLASSSEDVSTVTALTRSAVTGPLVKVASL
                     SYGMRRVLGRRRTLALIRTRRRRERT"
     misc_feature    16775..16789
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.75"
                     /tool="antismash"
     gene            16885..18801
                     /locus_tag="FOF52_RS10335"
                     /old_locus_tag="FOF52_10260"
     CDS             16885..18801
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011292497.1"
                     /locus_tag="FOF52_RS10335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_10260"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_248593603.1"
                     /sec_met_domain="Pkinase (E-value: 6.9e-17, bitscore: 59.6,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRRSERTISVLVPPDLAPTAPEDPRSIGPYVLVGRLGATEAGHV
                     YAAVHPDVEPEVLLAVKVVPPSRVADEAARARLEQRLRALGAVDGRCYVPPVAFDVHGT
                     PAWLAMRYSPGTPLEQYTDQRGPMSLGRLTALAAGLAEGLSALHSLDLAHGGLTPGSVL
                     LSSAGPRLLDCALSGEAAAPPGAASWLSPERLRGGEPTPACDVFAWGAVLAFAGTGRPP
                     FGTGTPEEIAERIESQQPDLDGLADEIRPLLESALSADPEQRPDTRDLVRSAIDLWESS
                     LGSVGSEAGPGSGVTRVLNREWQGIVEPALLPRVVHVDGRAKGRKSGRLSLTMPVPVLP
                     SPQRSAPPPAASTAAPAAEQDGAAAPREEAAADGAAEQRDGAAAPAAAGSETAAATATV
                     AASTAVAEPPPPPSSSAPAPPPPAAPATQPSGGAGTGGPNRRLLLLAGGAGAALLLVGG
                     LVWGAVSLLGGDSPEPGEDTAASDTADEETVQADPVPEWDTGTLVVRLDSSSEVSLLSG
                     PWPYTPVEPASGDDAFAGLDGAALTPQEWSEAWAPVEGVGQPLEALIASDAEVMCAHFC
                     LNPDQVYVDAEGRGTYAVTGRDLANYLSWGDVVIAEVTFGDPDPETGLPVITGATELYP
                     PAG"
     gene            18911..20560
                     /locus_tag="FOF52_RS10340"
                     /old_locus_tag="FOF52_10265"
     CDS             18911..20560
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011292498.1"
                     /locus_tag="FOF52_RS10340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_10265"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_248593604.1"
                     /sec_met_domain="Pkinase (E-value: 1.7e-38, bitscore:
                     130.4, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPHGFPPDLSPLHPDDHGIRIPGYRIVGRLGEGGMGVVYAALDAR
                     RQPVALKLMRAEMSPDIGQRRRRFHSEVRTLRRVRDEHIVPLLDAGVSGGRPWLATAYV
                     PGQNLQRCGRLSGPRLLLLARGVARALHAIHRAGVVHRDLKPSNVMIRPDGVPVVLDFG
                     IARSLADTGLTGTGAPPVGTAGTISPERYRGVSAPPADVFAWGCLVVFAATGRQPFSGS
                     SPEEVMHRVLHGQPDLHGFTGPLADLAVRAMARDAGARPTAHQLVEALGSAEAPARSAP
                     PRSGRSAGDTATLLVLEMQRHHDDPLPWLRRNRERLVGEARRLGVADRALLDLLHNLPE
                     EGLSSAAVEEALAVLAVRLAPHERPRYRGHPVDEDGLVALACGGAAEQALLRRLLGERS
                     LIVERYAARHLCRHGLCVGKYLGRGCRILRRLRSEVAAVVAHTREPLRELRHQIWAEHD
                     ALGHPRILLPPDRELTDRVHATALLVRRRSSELDRHREEVLALRCPTRWWASQQEAVLR
                     ADPNTDRGLAWVVIASVAADTARRFAEAAAAE"
     gene            complement(20602..21138)
                     /locus_tag="FOF52_RS10345"
                     /old_locus_tag="FOF52_10270"
     CDS             complement(20602..21138)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011292499.1"
                     /locus_tag="FOF52_RS10345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_10270"
                     /product="hypothetical protein"
                     /protein_id="WP_248593605.1"
                     /transl_table=11
                     /translation="MVLTGRRRRPANGRAPAVHLAGWLFADLLLVLFLVSLSAQNAPEA
                     PEPPPPPPPKLLSPDSCEFTVRLGNGFDVDPDRVVAELGRILSDPDDSDFNTDDGHGEP
                     SDKCREHLTEQREIGFVIAFGSGSNQQIGAAKEFAAEVVEIAVAEIPQFEGAKYRELWT
                     GGSPGAVELSVFFLE"
     gene            complement(21129..22343)
                     /locus_tag="FOF52_RS10350"
                     /old_locus_tag="FOF52_10275"
     CDS             complement(21129..22343)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011292500.1"
                     /locus_tag="FOF52_RS10350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_10275"
                     /product="hypothetical protein"
                     /protein_id="WP_248593606.1"
                     /transl_table=11
                     /translation="MSASTDRDHDLADIAEQLDRYARTAPPAGAQLLRSLARGLADGGA
                     GLAGTDLAAAYPPDSLMPDASPPRWTHLLLWLLRGVRDVLIFLPVFWTWYQLMQVLSAF
                     GEAPQGANFLYGWQQGGFTGTAQFEPLSTTASWVCVFLLGVIGATLLVHVLEGAVEAFS
                     DRSRQREEIVQLLALATYLIPDRPDSVRAEVRGANETLQGVRRAMAGMENALGAATDSM
                     HRAAADMRQAAADIAEAFTGDPRQQLVDALDAWQTRMGQLADAVREARTPAELLDSLTA
                     LTRSTVEGQDRLSEQTRHTLDLLRQQNDLVEQRTAESARFAVDTMDRIAAALEKLEKVS
                     EELAAAQDRLGAFTEQSSSTLRQALDEFTDLADDLGFLVKGVQRDVANRRDGEADGGRE
                     EDPWS"
ORIGIN
        1 ccgcggactc gtacttgaac ttgccgtagt ccatcagctt ggcgaccggc gggcgggcgg
       61 tcggcgcgac ttccacgagg tcgagatcgg cctcctgggc caggcgcaga gcgtcggcca
      121 cgggaactat tccgacctgt tccccgttgg ggccgacaag acggacctcg ggcacccgga
      181 tacggtcgtt gatgcggggc tcagcgctga tgggacccct ccctaaaatt cgtcgggttc
      241 tcgttcggtg cgggggtctc ctgagtggct gtgcgccgga acaacgaaac cccgccagct
      301 ggtgcaagcg gggtcgaacc accgtacgga cgggacgccg caacggtttc cctcatacgg
      361 tttctatccg ggacccgcag tacccgtggg cactacaggt gggaggctcg ttcctccgct
      421 tgcggtccgg cgcgcgtaca tgcaccggat caggtcgttg ctcactctac caagaaaacc
      481 ggactgccgg gaacgccctg tcgccccgga cgtaccgcca ccggattccc ctcactaggg
      541 agacaacgct cacggctcca cgttattccc ggccgcccgg cgcgccaact cggcctcacc
      601 ggcgacacgc atcgcctcga ccggggcggg ccggccggtc atcagggtca gctgggccgc
      661 cgcctggtgc agcagcatgg ggaaccctcc gatcacggtg gaccccgccc cggccgccgc
      721 ggcccccagc acggtgggcc acggcgcgta gacgacgtcg aagaccgccg ccgaggaggc
      781 ggccaccgcc ggggcccacc ggtcggccgc tccggcggga accgtggaga ccaccaggtc
      841 cacccgcagg tgctcgtcga tgtcggcgag cggggccagc gccacctcgg ccgacatgcg
      901 ttcggccgcc gcggcgaggt cgccggtgcg ggcgaggtcc cgggccagca cggtgaccgc
      961 accgggttcg gtggcgccca gccggcgcac ggccgcgagc gcggacgcgg cggtcgcgcc
     1021 cgcgcccagg atggtcacgg tgtccagccg ccgcaccccc gcctcgcgca gcgcctcggt
     1081 gatcccggcc acgtcggtgt tgtaggcgtg ccgccgcccg tcccggaaga cgatggtgtt
     1141 cgccccgccg acctcgaccg cggtctcctc gacctcgtcc gccagcgtca acgcgacctt
     1201 cttgagcggc atggtcagcg acaggccggc ccaggagtcg tcgcacccgt cgaggaacgc
     1261 ggccaggccc cgttcgtcgc actcgtggcg gccgtagtgc caccggtccg cgatgccgag
     1321 cgcggtgtag cccgccgtgt gcagcaccgg cgagagggag tgggcgatcg gcgagccgag
     1381 cacggccgca cgtttcacgg gttcctcctg cggggtcgcc tgccgtggcc gcggcccggc
     1441 cacggggtgg tcgctcagtt ggcctggctc tggttgaact cctcgaccag ttcccagaac
     1501 tcggcctcgc tgtcggtgaa cttggtgacg ccgttctcgg ggtcggtggc cacgaagaac
     1561 agccacggcc cctcctccgg ggcgagcgcg gcctcgatgg cgtccttgcc ggggctgacg
     1621 atgggaccga ccgggagacc ctcgtggaag taggtgtcgt agccggtctc gtcgccgcgg
     1681 caccggtcct gctgctccag gttgatcgcg atgccgtact cgccgagggc gtagaagcag
     1741 gtgctgtcca tcttgaggta catgccgtcg gccaggcggt tgtagacgac ccgggcgatc
     1801 ttgcccatgt cctccacctt tccggactcg gcctgcacga tcgcggcgat cgccatgatc
     1861 tcgttcgggt cgaacccggc ctcctcggcc cggcgctcca gttccacctc ggtggccacc
     1921 ttccggtact gggccaccat cttgcggagg atctcggctg ccgaggcgtt gctgtcgaac
     1981 tcgtaggtct ccgggaagag gtacccctcc ggtccctgcg tggcgtactc gggcagcccc
     2041 agggcgccgt ggtcctcgta ggcggcctgg aactcctcca gcgggatgcc ggtctgctcg
     2101 gcgagcctct ccaggatctg cccggaccgc agcccctcgg ggatcgtcac gttgagcgcg
     2161 atgcggctgc cggggtcgag cagcagcgcg atggccgcct ccgcgctcat ctgcatccgc
     2221 agctggtagg tgccgggaac gaagttggcc tcggagaacc ggatctcgtt ggtgaacgcg
     2281 cgcacgctgg cgatcacccc ggcctcgtgg agcttctcgg cgatggcggt cccggtgtcg
     2341 ccctcctcga tgacgatgct gacctcgccg gtgccctcgc cggagtagtc cggggggatg
     2401 acgtaggtgc gcagcagcag gtaaccgccg gcgccgacgg acaccacgaa cagcgtcagc
     2461 acgagcacgg cgctgaccag ggcggccttg ctcttcttgc gtttgcgtct gctgctggcc
     2521 cggcggccgg aggctcgtct gccgccgcgc cggccgctgc gggaacgctg ggggggttcc
     2581 tcgtcgtcgt cctcgtcgaa cggcagcgcg aaggagtcgg ggtcctcctc gtcgggggtg
     2641 gtggcgcgcg tccgccgttc tctcctgggg ggttcctcgt ccaccgccgg gggggcggcg
     2701 gcgtgcgccc ggcgtctcga ccggggcgcc gcgtcctcgt cgtcgggggc gggaggacgc
     2761 gcccggcggc ctctgggggg tgcgtcccag tccccctcgt cgaggacgcg cctgcgggag
     2821 ccggctctgc cggccccgtc ctccgcgtcc gccggggggc ggtgttcccg ggggacacgg
     2881 agcggatcat ccgaccacgc ctcctggtgg cggaggccgt cccggaggcg gggggcgccc
     2941 cggtccgccg gatgcgctgc gccgtcctcg ggaccggcac ggcgtccccg gctgacggag
     3001 gtgtccgggg cgaccgtggg acggccgtgt cccgccgtcc cccacgcctc gaccgtctcc
     3061 gctcccggac cggacgccgc ccggtccggg gtcgggcggg gggtggacgg ccactcctcg
     3121 ctgtcgggtt tgcgccgccg gccgcggggc cgttcgagca gcgcctcggc ctccgtgggg
     3181 ggaagagtga aagagccggt gtcagcggga cccggccgtc tgcggcgccc ccggggacgc
     3241 tcggcctccg cgggccggtc cgtctccgtg ccggagacgg gggctgcggt ctgcgccgct
     3301 cggggggacg gccacgcggt gctgtccgcc cggggggtgt ccacgcgccg ccggcgcccc
     3361 acgccgcgct cgtcccggta gccgcgcccg ccgtagtcga cggccgaggc cccggtgcgg
     3421 ggcgcctcgg cctcccggtg gagcggccag ggatcggtca gcgggtcggg ccgacgcgct
     3481 cggcgcggat agtcgtcata ccggtcgttg ccgttcatgg cgtcccctcg acgagttcac
     3541 cgggaggcag ttgggtacgc cgctcggtgt cgagggcgtt ctgcagcagg acggtggcgg
     3601 cggcctggtc gatgaccgac cggcgggccc tgccgccgcg ggccccccgc ctgccgtagc
     3661 tggcacctgt ctgcaactgc tgctgcgcgg tcaccgtggt cagccgttcg tccaccagcc
     3721 gcaccggaac cggggcgagc ttgcgggcca gcgtccgggc gaaggcgcgt gccgcacgcg
     3781 cggcacgccc ctcggctccg gacagcgacg ccggatagcc gacgatgacc tcccgggcct
     3841 cgtactcaag cacaagagcg gcaattctgt cgagatcccc cggcccccgg cggatcgtct
     3901 ccaccggggt ggccaggatg ccgctgggat cactgcgggc caccccgata cgggccgtac
     3961 cagggtccac cgcgagccgc acgcccgttc tcaccggggc gccccccgga ccgggcggac
     4021 accggcgtcc gccgctcccg ccaccgtcgg gaaccggggc gacggacgcc gccccgcgct
     4081 cacgaccccg ccactctctg ttccacggcg cgcagcgccg tctcgaccgc gccggcgtcg
     4141 cttccgccgc cctgggcgat gtccggccgt ccgccgccgc caccgccgag cgcgcgggcc
     4201 gccacgccca ccagttcccc ggccttcagg ccccggccct gggcctcctt gttggccgcc
     4261 accaccacga cgggccggtc gccggggacg ccggcgacca ccacgaccgc gggcgcgtcc
     4321 tcaccgagcc gtccgcgcac gtccagcgcg agcttgcgca tgtcgtcggc ggtggtgccg
     4381 tcggcgacgc ggtgggtgac cacgcgggtg ccgccgaggt cgcgggcgcc ggcggccagt
     4441 tccccggcgg cctggagcac ctgggcggcg cgcagccgct cgatctcctt ctccgcggcg
     4501 cgcagccggc tgatcacggc gtcgatgcgc tgcgggagtt cctcgcgcgg cgccttgagc
     4561 tgttcggaga gctgtcccac gagcgcggac tcggtggaga cccggcgcag cgcgtcgagg
     4621 ccgaccagcg cctcgacccg gcgcacgccg gagccgaccg aggactcgcc cagcaccttg
     4681 accaggccga gctgcccggt cgcgccgacg tgggtgccgc cgcacagttc gcgggagtag
     4741 tcggtcatgt cgaccacgcg cacccggtcg ccgtacttct cgccgaacat ggccagcgcg
     4801 cccatctgca gcgccttgtc gagggtggtc tccatgtact ggacctcgat gttgcgggcg
     4861 aggacctcgt tgacctcctc ctcgacgtgg gcgatctcgg ccgcgtcgag cggcttgttg
     4921 gcggtgaagt cgaaccgcag ccgtcccggc tggttctccg agcccgcctg gcccgcggag
     4981 gggccgagcg cgttgcgcag cgcggagtgg atgaggtggg tggccgagtg cgaccgggac
     5041 accgaggcgc gccggtcggt gtcgatggcg gcgtgcacgg tgtcgtcgac gacgacctcg
     5101 ccgtcgcgca cggtgccgcg gtgcacgaac aggcccttga tgggcttctg cacgtcctcg
     5161 acgtcgacca cgccgcggcc gtccacggcg atggtgccct tgtcggcgag ctggccgccg
     5221 ctctcggcgt agaacggggt gcggtcgagg accagctcca cccggtcgcc cttgcgggcc
     5281 gcgcccgtgg cctcgccgtc gacgatgacg ccgagcacgc gggcctcgcc ctcggtgtcg
     5341 gtgtagccga ggaagtcggt gggaccgccg gcctccagca ggcgggcgta gacgctgacg
     5401 tcggcgttgc cgagcttctt ggccttggcg tcgcgcttgg cggcctcccg ctggcgctgc
     5461 atgagccggt ggaaggtgtc ctcgtcgacc ttgaggccct gttcggaggc catctccagg
     5521 gtcaggtcga tggggaagcc gtaggtgtcg tgcagctgga aggcgtcggc gccggagaac
     5581 tcggtgccgc cgctcttcct ggtccgttcg accacccggt tgaacagcgt ggtgccggcg
     5641 cgcagcgtgt cggcgaagtt cttctcctcg gcgtcgatga cgctgtggat ctggtcggcg
     5701 tcggcgcgca gctcggggta ctggtcgccc atcgcgtcga tcgccacgcc ggtgaggtcg
     5761 tgcaggtgga acgactcgtc gccggagagc aggcgcaggt tgcggatgga gcggcgcagg
     5821 atgcggcgca gcacgtagcc ccgcttctcg ttgccgggct tgacgccgtc ggcgaccagc
     5881 atggtggcgg tgcgcacgtg gtcggcgacg acccgcaggc tcacgtcgga ccgctcgttc
     5941 tcgccgtagg tgactccggt gagctccgcg gcgcggcgca ggatgcggcc gagggtgtcg
     6001 gtctcgtaga tgttgtcgac gccctggagg atggcggcca tgcgctccag gcccatgccg
     6061 gtgtcgatgt tcttgctggg cagctcgccg aggatcgggt agtcctcctt gccgctgccc
     6121 tcgccccgct cgaactgcat gaacacgagg ttccacactt cgaggtagcg gttctcgtcg
     6181 gcgacggggc cgccctcggc gccgtagtcg gggccgcggt cgaagtagat ctccgagcac
     6241 ggtccgcacg ggccgggcac gcccatggac cagaagttgt cggccttgcc gcgccgctgg
     6301 atgcgctcgg cgggcagtcc caccttctcc cgccagatgg cctcggcctc gtcgtcgtcg
     6361 aggtagacgg tcacccacag gcgctcgggg tcgaagccga acccgccgtc ggcgacggag
     6421 ctggtgagca gctcccaggc gaacgggatg gccttctcct tgaagtagtc gccgaaggag
     6481 aagttgccca gcatctggaa gaaggaggcg tgccgcgagg tcttgccgac ctcgtcgatg
     6541 tcgatggtgc gcacgcactt ctgcgcgctg gtggcgcgcg tgtacggcgg ggtgcgctgt
     6601 ccgaggaagt acggcttgaa cggcaccatg ccggcgttga ccagcagcag ggtggggtcc
     6661 tcagcgacga ggcttgccga gggcaccacg gtgtgtccgt tcttctcgaa gaatgcgagg
     6721 aagcggcgag cgatctctgc cgtctccatg tgatgccctc ctggtgaata ggactccagt
     6781 cgaccggtac gggtggactg aggtgccccg gtcgagactc ggcgcgtgag cggatatcag
     6841 gcgcctatgg taggtgggaa cggcctgtgg aggtttcctg ttccacgccg tcccggcggc
     6901 tccgtgctgg agacacccta ctgacgcccg gtcggtgcac tgtcccgcgg caacccctcc
     6961 gaaacgggga gaatgcggtc acgcaccgtc cacgtccaag gctactctcc gggtgcgcga
     7021 cgcacagcag aataagacac gcccgaaacc gggggatcgt ggcggttcag gatcttagcg
     7081 gccctcgtcc gggagtaacc cactcgtgat cttggcccca gggccagacc cgacgccgtt
     7141 tctgccccca gggcccttcc ccggcgcgag ggtacgggtc aggctccgat gaggcggctg
     7201 gtgaatccgg cgtcgacgag tgcctggtag gcggcgtgga cgtcgtcggg cacgtgctgt
     7261 tcgacggcga agccgcggtc ggggtactcg atgacccgtt gcaggtcgcc gaccatggtg
     7321 tcgatgacga gccggtcgtc gccgatgccc gcgaggtagt cgcggaagcc caccggttcg
     7381 gaggcgcaca ccacggtgac ctcgggccag acccggcggg tggtggcgta ggcgcgtcgc
     7441 tgcatgtagg gcatggtcac cagcatcacc gtggccgggg ccaggcccgc ctcggccagc
     7501 agttgtcggg acagggtgat gttctgcccg gtgttggccg cccggggctc caccaggacg
     7561 gcctcgtcgg gcacccccag gtccaggacg tgctcccggt agtgcacggc ctcgccccgg
     7621 ggaaacacct cggcggtgga ggggctgttg ccgccggtga gcaccatgcg ggcaaagaat
     7681 ccggcctggt acagcttcgc cgcgcacgcc gccacgccca ggtcgtggca gcccagcacg
     7741 accgccacgt ccaccggccg cagctcatgg cccatccggt ggtagtccca gatccgctcg
     7801 gccaggcggt agtgctcatc actgatcgtc ggtggagtgt tggacattgg tgtctctctg
     7861 gtcgtgcctg tggaggtctg cccccttgcc cctgggaccg cccggggtgt cccgctacgg
     7921 ctccgcggca cgggcgatac gctgccccag cgtctccggc cgaggggcgg atgcgtccat
     7981 gagctctcct tcgcgtactg gccatggcga ggacagccta cgcacctctc cgacgcgagg
     8041 ggctgtcact ttcctggtac tccggaagac accgcgccac tactctcggc acccgaagcc
     8101 attctttctg tggctgaccg gagtatccgg tcactccgcc aatccgtgct cgctcgtatc
     8161 ccctatcgcg atcggacgaa cacgccgcac tcctactcag ccacgacaac cgacgttggg
     8221 aagagtccgt gtcctcacca ctcccgccca ctcctgaaca ggcgcgcatg gccatggttg
     8281 acgccatggc ggccgagcgc gcacgactcg gcgcacagcc gctgccacga gccgtggagg
     8341 aagccctgcg tgccgttccc cgcgaggcgt tcctgcccgg actgccgctg accgaggcct
     8401 acgacccgca ccaggcggtg gtgaccaggc gcgacgagga gcggggcgtg gcgctcagtt
     8461 cggtgtcggc gcccaccatc gtcgccacca tgttggaacg tgccgacctg cgtcccgggc
     8521 atcgggtgct ggaggtcggt tccggtggct acaacgccgc tctgattcgc cgtctggtcg
     8581 gcgtggacgg ccaggtggtc tccatcgaca tcgaccccga ggttgtgacc cgtgccgagc
     8641 ggtgcctgaa gagcatcggc gtcgacgacg tgcacctggc ggtcggcgac ggcgcccacg
     8701 ggttcgccgc ccgggcgccc tttgaccgga tcattgtgac cgcaggagcc tgggacctgc
     8761 cgcccgcctg ggagcagcaa ctcgccgagg acggggttct ggtggtgccc atgcggattc
     8821 ggggcctgac ccgctgcctg accctgcgcc gcgctcccga agaggggtgc tgggaggcgg
     8881 tggcggtgga catgtgcggg ttcgtgcgga tgcggggccg ggacgagcac tgggaggcca
     8941 tgccctgcct ccacgacgag gacggctgcc aggtcgcgct gcgtctggag gacggccccg
     9001 aagtggagga gaaggccctg cgtgaggccc tggcctgcga gccggtcact gtctggtcga
     9061 acgtcgaggt gggcgcggaa gagcccaccg actcccagga cctgtacctg gcctcggtcg
     9121 ccgaccggtg ggcgcagttg accgccgagc gcggtgcgat caaagccgga ctcgtcagcc
     9181 cgatctcccg cctgggcacc ccggccctga tcagtgccga gggcaccggc ttcgcctacc
     9241 ggaccctgcg ccgctgcccc gggcgcgcgg accggtggga gttcggcgcg gtcggccacg
     9301 gcccgcatgc ccgcgcaacc gccgaacacc tggcccatct gatcggtgag tgggaccgcg
     9361 accaccgccg cggccccggc ccccgcatca ccctgtttcc cgccaccacc cccgacgacc
     9421 gcctgcccgg ggggcgcgtg gtggacaaac gccacacccg cacggtcctg acctggacca
     9481 tcacccctta gagagagaaa ggaaggaaca accagtgagc acactcacgg tctccgacac
     9541 ccccgacggc atggtcccgg tgagccggga ccgccacccc gccggcgacc tgttcgacct
     9601 ggacctgcgt gtccacgtgc cgcagcaggg cgagccgctg tggtcgatga ccaacgacgg
     9661 atgcggcaag acctgcgaga cggcctgcac ccccagctgc accgacaacg gctgagttcc
     9721 tccaccgact cctgggcgcc ttcctcgggg cgcccaggaa gttcctgtcc ggagaaagga
     9781 ttcccggtgt acgcccccct ggaatcggtg ggcctgaccc tgcgcgccac cacccgcacc
     9841 cccgacacgg aaaccccctg gcctgatccg ggcaccgccc ccatcgagga gctgcgcggt
     9901 tggattcacg acctccacac ccgtgaccac gccctgatcg aggccccggc cgtggccagc
     9961 ccttccctag tccggcagtt ggacgccatc gtcggcgccg atgccgtcgc ggcgaagaag
    10021 gtccgccggg ctgctgtctc ccctcatgcg ctatctgctc cgctacggtg gccgccccac
    10081 tccttacggg ctgttcgcgg gggttgctcc gctgacttcg ggtggtcgaa cccgcgtccg
    10141 gtggggcgag caccaccggg agacagccca gccggcttcg gcctggctgg ccgtccgcgc
    10201 ccgtcaccac ccagtcccgg gctccttcac cactgtggtg gcggcctcca ccgctcgtgt
    10261 ccggggcgat cggctggtcc tgtcccacaa gcccggggca gacgatccgc gccaggcggc
    10321 cgaggtgtcg gtacgtctca ctcctgccgt cgccctggtg gtggagaacg cccgaacccc
    10381 tgtgccgctc gcggagcttc tccgcatgct cggcgactcc tatcccgacg ccgatccgcg
    10441 agaggccgcc gcgctggtgg actccctcct ggagcaccgc atcctcatcg gctcccagcg
    10501 gcctcccgtc tggcatccac ggccactggc ccacctggcc gaccacgatc ccggactgaa
    10561 agcggccagt gaactcctgg agtgccacaa cgatcccggt actcccgccg gggaacgccc
    10621 cggcctgcgc ggccagatcc tgcggcggct accggacacc gacaccgaga cgctgccgcg
    10681 gctggcggtg gacacccgcc tggacgtgga cctcgtcctg ccccaccagg tcgcccatga
    10741 gacagcccgc gcagccgggg ttctggctac gctggcccca caccccaccg gccaccccgc
    10801 ctggatcgac taccacaccc gttgcctgga gacctacggc caggggacgg ttgtgggact
    10861 gctcgacctc accggccctg ccgggctggg attcccacac ggctaccggg gctcacgtct
    10921 gtccgaaccc gccccggacc ggggaaacct cgaacgctcc cggattctgg tcgccgccct
    10981 gcacaccgcc gccctccagg gcctgttcga gatcgacctg caagacccgg cctggcagca
    11041 cctgagcggt gagcagacgg ttcacccgcc ggtacacgtg gaactccgcg cccaactgca
    11101 cgctgccacc cccgaagcgg tggacgcggg cgatttccgt ctgtggatca ccgcagtttc
    11161 ccgaggggtg ggcacgctca ccggccggtt cgcccacctg gacggcatgg ttcccgctga
    11221 tctggaccgg gctctgccca cactcaccga gagggctgta accgttcagg tcctggctcc
    11281 gccgatggcc gacaccgcgg cccatgtggc ccgttccccc gtggtggctg ctcacgtact
    11341 ggtcatcgac gaacacccgc cgccggctcc cggaatcgaa gtcatcaacc cgcgggaggt
    11401 gggcgtgcgc gtcgacgccg accacctgcg gctgctgcac ctgcccaccg aacgcgtgat
    11461 cgaaccgttc ctggcctcgg cgctggaacc gcaccactac acccaccccc tggcccggtt
    11521 cgtcaccgaa ctcccccgcg cccgtaccct gccctctctg gggttcacct ggccgtccgc
    11581 cgccagtgac tgcgttttcc tgccgcggct gcgcagcggc cgcaccgtcg cggccccggc
    11641 ccagtggcgc gtcaccgccg aggacctgtc caccgtccgc tcccacccgc cgctgccgca
    11701 gcgggtccag ctcgttgagg gcgaacgctg tctgcccctt gacctgtccc ggtccgccca
    11761 ccgtcacctg ctggagaccc acctggcacg gtacggcacc gcggtcctca ccgaagctcc
    11821 ggatgaggag gcgttcggct ggtgcggcgg ccgcccccac gaactcgtgg ttccgctgcg
    11881 ccgcaccgca gcccctgtcc cggctcctca gctctcggcc gttaccgccg tatccgcccg
    11941 tccgcagtcg ccgccggtgg cggacccgcc cggcaccggc ccctggctgt ccgtccacct
    12001 gtataccggc cctgacctgt gcttgctgat cctggaccgc cttcccgaac tgtgggatct
    12061 tctgggaggg cctgtcgatt tctggtttgt gcgctaccgc gaccatgacg gcccgcatct
    12121 gcggctgcgg ctgcgcaccg aaaccagccc cgcggaaccg accgctgccg tgggcacctg
    12181 ggcacggtct ctgcacgcct gcggcctgct gcactctctg agcctgcaca cctatcggcc
    12241 cgagaccgcc cgttacggcc acggtcccgc gctggccgcc gccgaggctt tcttcgtcgc
    12301 cgacagccgc gccgcccaga cccaactggc ctcggccgac catgacccca ctcgcacccg
    12361 tgccctggcc gcggcctccc ttttacgcct ggccgccgct gctgataccg gcactacctg
    12421 gctgctcgac catctgcccc gcccagccga tcctgtggac cgtgcggccc gtgccctggc
    12481 cgcgcgcatc ctcacccggc ccggcagctt ctccccaccg ttggcagccg cctgggcgga
    12541 ccgcgaccag gccctcaccg cctacctggc ctgcctcccc cgtccgcgcc aagtgctgcc
    12601 ctccctgttc cacatgcacc acaaccgtgt ccgcggaccc gaccgcgatg acgaacagcg
    12661 agtgcaggct ttggcccgcg cggtcgccct cacccgcaga cacacccgaa cagccgggaa
    12721 accctgatgc cgatccgtgc cggacgcgcc gcggccgccg cggccgcgcg cctgaccgag
    12781 cccgccgccg tgcccctagg tgctcctccc cagtccctgg cggcgggagc gctcggaatc
    12841 gcgctcgtgc acatcgaacg cgcccgcggc ggcgacgagg cagcatggcg cagtgcccat
    12901 gcctggttgc aggctgcggc ccgcgacggc gtggacgcca ccgaccgggc ccgcctcttc
    12961 cacggtgctc ccgcgctggc ggctgtcctg gtctgcgccg acgacgaaag cggacgctac
    13021 gccacggccc gcagcacgat gacgcaccat gtccgtgccg tggcccaccg tcgcctcgat
    13081 gcggcatttg cccgcatgga ccggggcgct ctccccgtct tcggcgagta cgacctcctc
    13141 agcggcctga ccggcatcgg cgccgtactg ctgcgcacgg acccggcttc ctctgctctg
    13201 gaacgggtgc tgtcctacct ggtccgactg accgaaccgg tccgtgtcga cggctgcccg
    13261 ctgccggggt ggtgggtggg ccacgctcct catcagggcg accggaccgg cttcgccggt
    13321 gggcacgcca acctcggcat ggcacacggc atcaccggcc ccctggctct gctctccctg
    13381 gcactccagc aaggagccat cgtcacgggg caggtcgggg cgatcgtccg catctgcgcc
    13441 tggctggact cctggcagca ggacgctccc gctggggctt ggtggccccg ctggatcacc
    13501 cgggacgagc accgcgcccg ccgctgcaca cagccggggc cgctgcgccc ctcctggtgc
    13561 tacggcactc cggcgatcgc gcgggcccag cagctcgccg ccctcgccac cggagacctc
    13621 gtcaggcagc gcagggccga gcaggttctc gccgattgtc tgaacgatcc ggcccaactc
    13681 ggccagatca tcggccccgg cctgtgccac ggttgggccg gggtgttcca gaccgtctgg
    13741 cgcaccgccc gcgactcgca caccccggtg ctcgcggact gcctgccgcg cctcgccgaa
    13801 cacctcatca cgtgcggcgc ttcccggcga ggcggggagg ccgggttcct ggacggggac
    13861 gcggggctcg ctctcgcgct ccgcaccgcc gcacgtcccg agcctcccgc gtccgactgg
    13921 gacgcatgcc tgctgatccg ctgaccggag ccttgactcc gtctgctggg gcgagaaagc
    13981 ggtgcgggag agtcccgccc ggaggagtgg agcggcgcat gcccgcttcg gtcggaacgc
    14041 cgagtgccct acagcgcgcc gctcgtggcc gcgcggagga aggcgtgcca ctcggcggcg
    14101 gggaaggtga ggaacccgag accgcgctgc gtggagtcgc ggaccgcgac ccgggcgggg
    14161 gtgtcgagga gaggacccgc ttcgacgcac ctgccaccgc cgttggcgct gtagctgctg
    14221 atgtgccagc cgacttcgac gcagctcttg ccgccgcttg gactgtagct gctgattctc
    14281 cagtcgagaa ccaaagtgtc gtcctggttc atctcatctc cttctggagt tccacgatca
    14341 acttggccga ctcctctgga ctcagactgc tctctcgaag acggttgtac aggacgtcga
    14401 ctctctctgc ttcgtgtgat tccaagtaaa cccctccagc gactcccacg gtgtaggcga
    14461 ccaaggggaa cgggtcttcc aagtggagca gggtgaaacc tccgtccgga cttgcgtggg
    14521 ctccagccga ataaggaagg actcgaatct cgatgttgga ctgtttccca cagaccagca
    14581 ggtgttggag ttgctctctc atcacgtccc ggccaccaac gatcctgcgc aaagctgcct
    14641 cgtccaggag aacctccaac tcgaccgcct tctcaccacg cagaatcttc tggcgtgcca
    14701 ttctcaactc gacgccccgc tcgatctgag cagcggagtc atggggattc accgcacgca
    14761 tccatgcttc cgcgtactcc ctcgtctgca acagcccgtt gaccggtgtc acctcgtagg
    14821 cgcggatatg cctggcccgg ctctccaacc acacgtagtc gacgaaccag tcggtgatgt
    14881 cgtcggagta cttctcccac cagccggtct tgctgacctc gcgggacaac tggatcagcg
    14941 cggcgcgctg gcgctccccc tccactccgt agaggtccat cagggcgcgc acctccggtt
    15001 cccggatggg cagtgccccg gactcgaact tgctgatcgc ggagaagctg cgctggaggt
    15061 actcggcact gtcggtcagc ttgagcccgt tctgttcccg aagttccttg agcatcttgc
    15121 ccagccactg cgcccgcagc gtcggccgcc gtttggacat ccgctacccc ttgagagaag
    15181 tttggaaaat ttgacctaaa acttgactta cccttgcccg tggatcactc tagcagtacg
    15241 tgaaggagag ctcacgaaga attactcagc gcaggccaga ggcccgcaaa acagacaaat
    15301 agaacaccgc ccgaagtgat tcttgagctt ggaaccctca accactccgg gcggtgccgc
    15361 agggaggaga acaccgcatg accgatgtcc acgcactccc cacgccgatt gtctcccagg
    15421 cgtggcagga ggtcgacacc tccatcgaca ccgagacccc gcggctgctc tgcgaggagc
    15481 agttcgagcg ctacaccgcc accgtggccg ccctgcggga ggcggccggt ctgaccgtgc
    15541 accactccgc cgaggacccg gcctcgctgc gggtctgcca cccccgcacc ggctacaccg
    15601 tggagctcga catgcgcgag gaccgcagcg ccgagtggtc cctggacgcg ggcgacgaga
    15661 tccccgagaa cacccccgcc gtccggctcg ccgccaccat caccggcatc ctcaacggcg
    15721 cgcccccacg gggctgaggg ctcgcctccg atccctttga cgatcttgac gggagagggc
    15781 tgcttcgcgc ggggaggcgc cccttcccgt caaggtcaac gccggggcag ttccgggtac
    15841 gggtcggcgg cgtagcggcg cagcagctcc tcctcgtggg cgcgcgcggc ctcggcgacg
    15901 tcctcgttga gttcgcgcag cgcctcccgg taggaggcga cccgccgctc gacgcggtcg
    15961 gcgatgccgc cggggctcca ggcgcgggcc gcgcgggtgg cgcggtacac cacgtagccg
    16021 ccgaccaggg cgccggccac gaaggagacg gtcctgccga tcacgtgcgc tccctcctgc
    16081 ggcgggtgcg gatcagtgcc agggtcctgc gccggcccag gacccggcgc atcccgtagg
    16141 acagcgacgc caccttgacg agcggcccgg tcaccgccga gcgggtgagg gcggtgaccg
    16201 tggacacgtc ctcgctgctg ctggcgaggt tggcggtgat ctcctcgacc cggtcgaggg
    16261 acccgttggc ccgctcgacc gtggccgcga ggtcgtcgag cagtggggcg gtgtgttccc
    16321 ggaactcgga cacggccctg gtggcctcgg ccagcaggcg ggcgagcctg atcagggcca
    16381 cgcacaggaa cacggccacc acggcccaga ccacggccgc gaccagggcc gcgagttctc
    16441 ctccggtgag catgcggact ccgctagcgc ttgaggtcgt tggggttgga agcggaccga
    16501 cccggggtcg gcgaggacgg cctccgatcg gcggccgtac ggcccgggag gtcgggccgc
    16561 cgcctcagga agaaccggat tgggtctgac actatcgcgg atttcctgtc caccacggga
    16621 cgcggcgcgg cgcttcccgc gccgcgtccc gccgccccgt ccttcccgcg tcccgcaccc
    16681 ggcggcgacg ccgcaggcca ggcaccttcg gtaaagaact cgccacacgg agtggcgtat
    16741 ttgctcgggc gtccccagag tggaggataa aaacgtctca gtctgacaag atgaccgagt
    16801 tctcccgata atgacggaaa ccaccgactg gctactgctg cgcgtttcag cacttcacct
    16861 cggacttttt gagacaggac cacaatgagt cgacgttccg aacggacgat ttccgttctg
    16921 gtcccgcccg acctggctcc caccgctccg gaggaccccc gttccatcgg cccgtacgtg
    16981 ctggtgggtc ggctcggtgc gacggaggcg ggccacgtgt acgccgcggt gcacccggac
    17041 gtggagccgg aggtactgct ggcggtcaag gtcgtaccgc cctcccgggt cgcggacgag
    17101 gccgcccgtg cccgactgga acagcggttg cgcgcgctgg gcgccgtgga cgggcgctgc
    17161 tacgtgccgc ccgtggcgtt cgacgtccac gggacgcccg cctggctggc catgcgctac
    17221 tcccccggca ccccgctgga gcagtacacg gaccagcgcg gccccatgag cctgggacgg
    17281 ctcaccgccc tggccgccgg tctggccgag gggctgtccg cgctgcactc cctggacctg
    17341 gcgcacggcg gcctcacccc cggcagcgtc ctgctcagtt ccgccggtcc ccggctcctg
    17401 gactgcgcgc tgtccggtga ggccgcggca ccgcccgggg cggcgtcctg gctcagcccc
    17461 gaacggctgc ggggcgggga gcccaccccg gcctgcgacg tgttcgcctg gggtgcggtc
    17521 ctcgccttcg ccggcaccgg gcgtcctccc ttcggcaccg ggacccccga ggagatcgcc
    17581 gagcggatcg agtcgcagca gcccgacctc gacggcctcg ccgacgagat ccggccgctg
    17641 ctggagtcgg cgctgtccgc cgaccccgaa cagcggccgg acacccgcga cctggtgcgc
    17701 tccgccatcg acctgtggga gagcagcctg gggtcggtcg gcagcgaggc cggtcccggc
    17761 tccggggtca cccgcgtgct gaaccgggag tggcagggga tcgtggagcc ggccctgctg
    17821 ccccgggtcg tccacgtgga cggccgcgcc aagggccgca agagcggacg cctgtccctg
    17881 accatgcccg tgcccgtgct cccgtccccg cagcggtcgg ctccgccgcc ggctgcctcg
    17941 accgcggccc cggccgccga gcaggacggc gcggcggcgc cccgggagga ggccgccgcg
    18001 gacggtgcgg ccgagcagcg ggacggtgcc gcggcgccgg ccgcggccgg gtccgagacc
    18061 gccgcggcca ccgccaccgt cgcggcttcc accgcggtcg ccgaaccgcc gcctcccccg
    18121 tcgtcctccg ctcccgcccc gccgcctccc gcggccccgg ccacgcagcc ttccggcggt
    18181 gcgggcacgg gcgggccgaa ccggcggctc ctgctgctgg cgggcggcgc aggtgcggcc
    18241 ctgctcctgg tgggcggcct cgtctggggg gcggtctcgc tgctcggcgg cgactccccc
    18301 gaaccggggg aggacaccgc ggcgtccgac accgcggacg aggagaccgt gcaggccgac
    18361 ccggtgcccg agtgggacac cgggaccctc gtggtgcgtc tcgacagctc cagcgaggtc
    18421 agcctgctgt ccggcccgtg gccctacacc ccggtcgaac ccgcctccgg ggacgacgcg
    18481 ttcgcgggac tcgacggcgc cgcgctcacc ccgcaggagt ggagcgaggc gtgggccccg
    18541 gtcgagggcg tgggtcagcc gctggaggcg ctgatcgcct ccgacgccga ggtgatgtgc
    18601 gcgcacttct gcctcaaccc cgaccaggtg tacgtcgacg cggagggccg gggaacctac
    18661 gcggtcaccg gacgcgacct ggccaactac ctgagctggg gagacgtggt catcgccgag
    18721 gtgaccttcg gcgaccccga ccccgagacc ggcctcccgg tgatcacggg ggccacggag
    18781 ctgtacccgc ccgcgggctg agcagggaaa cgcggcctcg cgttcccgcg ggggacttcc
    18841 cggcaatcac cggacaatcc cggcccggga gccgataatc gacggagaac ccccgaccgc
    18901 aggaacgtcg atgccccacg gtttcccgcc cgacctgtcc ccccttcacc ccgacgacca
    18961 cgggatccgc atccccgggt accggatcgt cggccgtctg ggtgaagggg gcatgggcgt
    19021 cgtctacgcc gcgctggacg cccggaggca gcccgtggcg ttgaagctca tgcgcgcgga
    19081 gatgtccccg gacatcggac agcggcgccg gcggttccac tccgaggtgc ggacgctgcg
    19141 gcgggtccgc gacgagcaca tcgtcccgct gctggacgcc ggcgtgtccg gagggcgtcc
    19201 ctggctggcc accgcctacg tcccggggca gaacctgcag cggtgcggga ggctgtccgg
    19261 cccgcgcctg ctcctgctgg cccggggggt ggcccgcgcg ctgcacgcca tccaccgggc
    19321 gggcgtcgtg caccgcgacc tcaaaccctc caacgtcatg atccgccccg acggggtgcc
    19381 cgtggtgctg gacttcggca tcgcgaggtc gctggccgac acggggctca ccgggaccgg
    19441 cgcgccgccg gtcggcacgg cgggcacgat cagtccggaa cggtaccggg gcgtgtccgc
    19501 cccgccggcg gacgtcttcg cctggggctg cctggtggtg ttcgccgcga ccggacggca
    19561 gcccttctcc gggtcctccc ccgaggaggt catgcaccgg gtgctgcacg ggcagcccga
    19621 cctgcacggg ttcaccggtc cgctggcgga cctggcggtg cgggcgatgg cccgggacgc
    19681 cggggcgcgt cccaccgcgc accagctggt ggaggccctc ggctccgccg aggccccggc
    19741 gcggtccgcg ccgccccgga gcggacggtc cgcgggcgac acggcgaccc tgctggtcct
    19801 ggagatgcag cggcaccacg acgatccgct tccctggctg cgccgcaacc gggagcgcct
    19861 ggtcggcgag gcgcggcggc tgggggtcgc ggaccgggcg ctgctcgacc tgctgcacaa
    19921 cctgccggag gaggggctct cctccgccgc ggtggaggag gccctcgccg tcctcgccgt
    19981 ccggctcgcc ccgcacgaac gcccccgcta ccggggccac cccgtcgacg aggacgggct
    20041 cgtggcgctg gcctgcggcg gggccgccga gcaggcgctg ctgcgccgcc tgctgggcga
    20101 gcgcagcctg atcgtcgaac ggtacgcggc ccggcacctg tgccggcacg gcctgtgcgt
    20161 gggcaagtac ctcggccggg gctgccggat cctgcggcgg ctccgctccg aggtcgccgc
    20221 ggtcgtggcg cacacccggg agccgctgcg ggaactgcgc caccagatct gggccgagca
    20281 cgacgcgctg gggcacccga ggatcctgct gcccccggac cgggagctga ccgaccgggt
    20341 ccacgcgacg gcgctgctgg tgcggcggcg cagcagcgaa ctcgaccggc accgcgagga
    20401 ggtgctggcg ctgcggtgcc ccacccggtg gtgggccagt cagcaggagg cggtgctgcg
    20461 ggccgacccc aacacggacc ggggactggc ctgggtggtc atcgcctcgg tcgccgcgga
    20521 cacggcgcgg cggttcgccg aggcggccgc agcggagtga cccgggctcc gccgcggtcg
    20581 acggccgcgg cggagcggcg ctcactccag gaagaacacc gacagctcga cggctccggg
    20641 actgccgccg gtccacaact cccggtactt ggccccctcg aactggggga tctccgcgac
    20701 agcgatctcg acgacctcgg cggcgaactc cttggccgcc ccgatctgct ggttgctgcc
    20761 gctgccgaag gcgatgacga agccgatctc ccgctgctcg gtcaggtgct cgcggcactt
    20821 gtcgctgggt tcgccgtggc cgtcgtcggt gttgaagtcg ctgtcgtccg ggtcggacag
    20881 gatgcggccg agttcggcca cgaccctgtc ggggtccacg tcgaacccgt tgcccaggcg
    20941 gacggtgaac tcgcaggagt cggggctcag cagcttcggc gggggaggcg gcgggggttc
    21001 gggcgcttct ggggcgttct gggcgctgag cgagacgagg aacagcacca gcagcaggtc
    21061 cgcgaagagc catcccgcca ggtggacggc tggtgcccgc ccgttggcgg gcctgcggcg
    21121 gcgtccggtc aggaccacgg gtcctcctcg cggccgccgt ccgcctcccc gtcccggcgg
    21181 ttcgccacgt cgcgctgcac tcccttgacg aggaagccga ggtcgtcggc gaggtcggtg
    21241 aactcgtcga gcgcctgccg cagagtgctg ctggactgct cggtgaaggc gccgagccgg
    21301 tcctgggccg cggccagctc ctcggagacc ttctccagtt tctccagggc ggcggcgatg
    21361 cggtccatgg tgtcgacggc gaaccgcgcc gactcggcgg tgcgctgctc gacgaggtcg
    21421 ttctgctgcc ggagcaggtc cagggtgtgg cgggtctgct cgctgagccg gtcctggccc
    21481 tcgacggtgc tgcgggtgag ggcggtgagg ctgtcgagga gttcggcggg ggtgcgggcc
    21541 tcccggacgg cgtcggcgag ctgccccatc cgggtctgcc aggcgtccag cgcgtcgacg
    21601 agctgctgcc gggggtcgcc ggtgaacgcc tcggcgatgt cggcggcggc ctggcgcatg
    21661 tcggcggcgg cccggtgcat gctgtcggtg gcggcgccca gggcgttctc catgccggcc
    21721 atcgccctgc ggaccccctg gagggtctcg ttggcgccgc ggacctccgc gcgcaccgag
    21781 tcggggcggt cggggatcag gtaggtggcc agggccagca gctggacgat ctcctcgcgc
    21841 tggcggctgc ggtcgctgaa cgcctcgacc gctccctcca ggacgtggac gagcagggtc
    21901 gcgccgatga cgccgagcag gaagacgcag acccaggacg cggtggtgct gagcggctcg
    21961 aactgggcgg ttccggtgaa gccgccctgc tgccagccgt acaggaagtt ggcgccctgg
    22021 ggggcctcgc cgaaggcgga cagcacctgc atgagctggt accaggtcca gaacacgggg
    22081 aggaagatga ggacgtcgcg gactccgcgc agcagccaca gcagcaggtg cgtccagcgc
    22141 ggcggggagg cgtcgggcat cagggagtcg ggcgggtagg cggcggccag gtcggtgccg
    22201 gccaggcccg cgccgccgtc ggccaggccg cgcgcgagcg accgcagcag ttgtgcgccc
    22261 gccggcgggg cggtgcgggc gtaccggtcg agctgctcgg cgatgtcggc caggtcgtgg
    22321 tcacggtcgg ttgacgcgct cacctggagg tctcctcaac tgcgggcgac ggggaggcgg
    22381 gggtgtcctg gggcggggcg gagacggcgg ggccgctctg ttcgggcggg gaggaccagt
    22441 cgctcccgcc gctcccgacg accgcgacca cgacgaggac gaccacgagc acgaggagga
    22501 cagccaggaa cacggcgaag agcagcgtcc ggaggacggg gctgcggcat cccctgccct
    22561 cgcccacgaa ggtgctgtcg gtcggtcccc gtcccgggtg gccccacacc ccccggcggt
    22621 ccctcccgtc cgggcgggcc cgctccggtt ccggttctgc cggtgcgggc tgctcggcca
    22681 cgtcctcgta ccactggggg gcgggctcgc cggggcgggg cgcggcgccg gtgccctccg
    22741 ccgcctgccg cggggttcgg ggggcctcgt ccggctcctc gtcggtggac gcgaagctcg
    22801 ggcgggcggt gtcgtggtcg gctccgtccc gggccgtcgg gcggtgctgt cgcgcggtgc
    22861 tcccggagga ggcgtacggc ggctccggga tcgacggttc gtcgcggccg ggatcgccgt
    22921 cctccgcctc cacggggccg cgggacggca gggcgagcgg aggagccgcc ttcttcgccc
    22981 cggtgctgct ccgcgacagc agcgaccgca gccgtccggg ccgcgtaccg ctgtcggcgg
    23041 tggcgggcgg ccgtccgacg atcgtcatga ggtcgggccg gtcctggagg ctctccacca
    23101 tttcggggga gaacacgcgc cacaggcgtt cggaggccgg ggtgtgggcg ctctcggtgc
    23161 gggagacacg gatcagcgcc aaccggaagt aggcgggccg ggggtacagt tccgcccgct
    23221 ccagttcctc caccttcctc tcggggaggg cgcggctgcc gggaggcggg ggcgtgcgcc
    23281 cgtcggccag cggcggcacc tctccgctgg ccagccacat caggtccgcg aaggcgagga
    23341 tgatctcctg tcccgcctgt ccgtagcggt ccctgccgcg cagggcgtac agctcctcct
    23401 ggaagtgtcc gtgctcccgg cacatccgct ggaagccctc gaccggcagc gcgtcggcgc
    23461 gccgcagttc gaccagggtc ttcacgatcc cgcggaactc ccggagggtc ggggcccccg
    23521 ccagccggtc caccaggtag gggagcgcgc cgtcgagcag tgcggcggtt tcgcggtccg
    23581 ccaggaaacc tctcagcctg taccagagcc gcaggcgctc cttgacggag aggtaccggg
    23641 ccgccaccgg gaggagggag gggagcagcc ggtgcgtgtc gacggcggcc aggtcctccg
    23701 gcaaccggtc ggacagccgg gagtcggtcc ggccggggcc cggggggccg tagccgagtc
    23761 cgagcaggtg cgcgaagacc gcctgccgcc gctccgcggt ctcgtcggcc agcgcgtcca
    23821 gcaggaagcc ccgcttccgc agcgcggcgc gcacctccgg ccggtcctcc ggaaggtccg
    23881 ggtactcctg cagggcggcc aggatcccgc ggcggaactc ccgggccatg acgtccccgg
    23941 tgtg
//
