LOCUS       NZ_CP051627            22502 bp    DNA     circular CON 21-APR-2024
DEFINITION  Thermobifida alba strain DSM 43795 chromosome, complete genome.
ACCESSION   NZ_CP051627
VERSION     NZ_CP051627.1
KEYWORDS    RefSeq.
SOURCE      Thermobifida alba
  ORGANISM  Thermobifida alba
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsaceae; Thermobifida.
REFERENCE   1  (bases 1 to 4903256)
  AUTHORS   Luzics,S., Horvath,B., Nagy,I., Toth,A., Nagy,I. and Kukolya,J.
  TITLE     Thermobifida alba genome sequencing and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4903256)
  AUTHORS   Luzics,S., Horvath,B., Nagy,I., Toth,A., Nagy,I. and Kukolya,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2020) NGS Platform, Seqomics Ltd., Vallakozok u.
            7., Morahalom 6782, Hungary
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: RA v. v0.2.1; CLC Genomics Workbench v. 11.0.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 331.0x
            Sequencing Technology             :: PacBio Sequel; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023208015.1-RS_2024_04_21
            Annotation Date                   :: 04/21/2024 13:45:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,356
            CDSs (total)                      :: 4,290
            Genes (coding)                    :: 4,246
            CDSs (with protein)               :: 4,246
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 44
            CDSs (without protein)            :: 44
            Pseudo Genes (ambiguous residues) :: 0 of 44
            Pseudo Genes (frameshifted)       :: 10 of 44
            Pseudo Genes (incomplete)         :: 35 of 44
            Pseudo Genes (internal stop)      :: 3 of 44
            Pseudo Genes (multiple problems)  :: 4 of 44
            CRISPR Arrays                     :: 12
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:37:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 547806
            Orig. end                         :: 570308
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP051627.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22502
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="2"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22502
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22502
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12502](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12502)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    625..642
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.9"
                     /tool="antismash"
     misc_feature    737..752
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.93"
                     /tool="antismash"
     misc_feature    739..753
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.47"
                     /tool="antismash"
     misc_feature    complement(741..752)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.26"
                     /tool="antismash"
     misc_feature    complement(781..795)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 19.37"
                     /tool="antismash"
     gene            846..1052
                     /locus_tag="FOF52_RS02480"
                     /old_locus_tag="FOF52_02480"
     CDS             846..1052
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291583.1"
                     /locus_tag="FOF52_RS02480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02480"
                     /product="hypothetical protein"
                     /protein_id="WP_248592210.1"
                     /transl_table=11
                     /translation="MPDRDEEIGGGGGQAVYVVDSGETAVRGELLTAVEVGDLDGLLAG
                     ETEEHAAPEAVLRAFELYQENLG"
     gene            complement(1131..1445)
                     /locus_tag="FOF52_RS02485"
                     /old_locus_tag="FOF52_02485"
     CDS             complement(1131..1445)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017572688.1"
                     /locus_tag="FOF52_RS02485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02485"
                     /product="AzlD domain-containing protein"
                     /protein_id="WP_248592211.1"
                     /transl_table=11
                     /translation="MMLWLAVLVTGLGCYLLKYAGLAAPRALLERPLVRRFATAVPVAL
                     LAALIALQSVAEGNHLVVDLPRLGGMAAAVVALLLRAPFLLVLVVAAATTAGLRALGVG
                     "
     gene            complement(1442..2164)
                     /locus_tag="FOF52_RS02490"
                     /old_locus_tag="FOF52_02490"
     CDS             complement(1442..2164)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016188504.1"
                     /locus_tag="FOF52_RS02490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02490"
                     /product="AzlC family ABC transporter permease"
                     /protein_id="WP_248592212.1"
                     /transl_table=11
                     /translation="MNRPALLPRLSSLARRPPVRDGFGVGLAVGFSGLAFGTTAVTSGL
                     SVAQACVLSLVAFTGASQFALVGVVAGGGNLIAGAVGALLLGFRNTLYGLRLSELLGWR
                     GPGRALAAQGVIDETTAVALAQHGRSDVRAGFTTTFVTLFVLWNATTLLGAVATESIGD
                     PTTFGLDVVGPATFLALLWPRLKEGGRTLVVALLGAAIALAATPLLPPGVPVLLASIAA
                     LVALGEDGEKTGSEGSGA"
     misc_feature    complement(2172..2192)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.42"
                     /tool="antismash"
     gene            2226..2666
                     /locus_tag="FOF52_RS02495"
                     /old_locus_tag="FOF52_02495"
     CDS             2226..2666
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017616962.1"
                     /locus_tag="FOF52_RS02495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02495"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_248592213.1"
                     /transl_table=11
                     /translation="MLDIVVARSERERAAVFVLRGAVFVAEQGVPVEEEWDERDAVADH
                     FLALRDGVPAGTGRLVVHGDEGVLGRLAVLRRFRGAGVGAALVAAIEERAVRRGLVAVE
                     LHAQTHALGFYERLGYTAYGPEFEEAGIAHRSMRKELARRGG"
     misc_feature    complement(2738..2752)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.37"
                     /tool="antismash"
     misc_feature    complement(2740..2757)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.34"
                     /tool="antismash"
     gene            2818..3480
                     /locus_tag="FOF52_RS02500"
                     /old_locus_tag="FOF52_02500"
     CDS             2818..3480
                     /EC_number="3.1.2.-"
                     /GO_function="GO:0047617 - fatty acyl-CoA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291586.1"
                     /locus_tag="FOF52_RS02500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02500"
                     /product="PaaI family thioesterase"
                     /protein_id="WP_248592214.1"
                     /transl_table=11
                     /translation="MTVDAHPIAELPNPADYGFTVVDPHELPAELLTLVDRVRELVDAV
                     AHTDADPAELAAASRTVDELTERLGARRRPVGAMVRQTWEGGRVDYNTLANVVSGPANP
                     VAPLRNLRATDDGLYGEVTLDSFYEGPPGFVHGGWVAALLDQVLGEATAVFGRVCMTGN
                     LTVDYRRPTPLNTPLTVSSRITGVERRKVFVSGEIRCDGKVTAEGSAIMVQLEAPPA"
     gene            complement(3449..4117)
                     /locus_tag="FOF52_RS02505"
                     /old_locus_tag="FOF52_02505"
     CDS             complement(3449..4117)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018184.4"
                     /locus_tag="FOF52_RS02505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02505"
                     /product="GyrI-like domain-containing protein"
                     /protein_id="WP_248592215.1"
                     /transl_table=11
                     /translation="MTLTTVPRTDFKKQYRNLYSATAAPAVVDVPPLRFLAVDGVGDPS
                     GPAYRRAVEALYATSYALRFALKHDAVVEYPVMPLEGLWWAPGRHDLPMEDRDAWHWTM
                     MIMQPPQADAGRVADALAVAARRRPSTAVDRVELREFAEGPSVQVLHTGPYAQEWPAVE
                     RLLSFADAHGYRICGRHHEIYLSNPARTAPERLRTILRYAVTGPGAAPSATPGEPPAAP
                     "
     gene            complement(4114..4911)
                     /locus_tag="FOF52_RS02510"
                     /old_locus_tag="FOF52_02510"
     CDS             complement(4114..4911)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF018184.4"
                     /locus_tag="FOF52_RS02510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02510"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_248592216.1"
                     /transl_table=11
                     /translation="MSEELMSIGAFARLCRLSVKRLRHYDELGLLPPRHVDPATGYRYY
                     GRDQVRDAMTIALLRGFDIPLPVITRVLASDRDAREAALRAEQRRLEERMAAQRRAWQA
                     LERLVSDGLLHQEVALSREPARRLLVSAAECAPEEIGAAVSRCVAQVTSAAADLSWTPP
                     LWGCFPVDLRERMTVAAGVEAPTAAPVPGTRVEHLPPGLAATAVHTGPYEQLTLTYQAV
                     FAWIHERALRPRGTVYEAYLDDPATSDPARLRTRIVVPLHEEE"
     gene            5156..6442
                     /locus_tag="FOF52_RS02515"
                     /old_locus_tag="FOF52_02515"
     CDS             5156..6442
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017583186.1"
                     /locus_tag="FOF52_RS02515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02515"
                     /product="MFS transporter"
                     /protein_id="WP_248592217.1"
                     /transl_table=11
                     /translation="MTQTGERAGGTAPADSRVRGIQRRVLTVLVAAQAVGGIGVGASLT
                     VGGIVARDITGTEAWAGTATTMFTLGAAVFALPLAGAAARRGRRVTLGAGWLFAAGGGA
                     VAVAGAQAGLFSVFLLGMVLFGAGGAVNLQSRYAAADLAADRTRGRDLSVVVWATTIGS
                     VLGPNLTEPGAVVAGWLGLRPLLGVFAISVAAFTVAGLLILALMRPDPLLTARALAPSP
                     APAAAARGPRSGALAALRGAPRAVLALVAVASGQAVMIMVMTMTPVHMERGGADLTTVG
                     LTISLHVAGMYALSPLVGWLADRLGRVPVLLAGQGVLLAAAAVSGLAGHGTAMITVGLV
                     LLGVGWSLGLVSGSALLAESLPPERRPAVQGLSDLLMNASGAASGALSGILLAHLGYGG
                     LNAVAAALTAPVLGWAVFALLGTVRKEAT"
     misc_feature    complement(5181..5195)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 24.08"
                     /tool="antismash"
     gene            6439..7257
                     /locus_tag="FOF52_RS02520"
                     /old_locus_tag="FOF52_02520"
     CDS             6439..7257
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (54-165). E-value:
                     6.3e-08. Score: 24.0. Matches aSDomain:
                     nrpspksdomains_FOF52_RS02520_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291587.1"
                     /locus_tag="FOF52_RS02520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02520"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_248592218.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.8e-06, bitscore:
                     24.6, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 9.2e-09,
                     bitscore: 32.8, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTERILLTGAGGRIGTLLRPRMTRPGRVLRLHDRRPLEPGPGVEV
                     VTGDATDLDAVTEAMDGVDAVVHLAARSTEAAWEEILHTNIHGGYVVLEAARRAGVTRL
                     VLASSNHAVGFHPRSAGTAPDYLFPRPDTYYGVSKVTLEALGSLYADRYGMDVVCLRIG
                     YCGPRPLGRHGLGTWLSPDDCANLVESCLSAPAPGFRVVWGVSDNTRRWWSLDEARSLG
                     YTPRDDAEVFAPEWEAGVPAEELDPEGPTVGGNFCGPHLDADRLRCGGGT"
     aSDomain        6601..6933
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FOF52_RS02520_NAD_binding_4.1"
                     /evalue="6.30E-08"
                     /label="FOF52_RS02520_NAD_binding_4.1"
                     /locus_tag="FOF52_RS02520"
                     /protein_end="165"
                     /protein_start="54"
                     /score="24.0"
                     /tool="antismash"
                     /translation="AVTEAMDGVDAVVHLAARSTEAAWEEILHTNIHGGYVVLEAARRA
                     GVTRLVLASSNHAVGFHPRSAGTAPDYLFPRPDTYYGVSKVTLEALGSLYADRYGMDVV
                     CLRIGYC"
     gene            7382..8296
                     /locus_tag="FOF52_RS02525"
                     /old_locus_tag="FOF52_02525"
     CDS             7382..8296
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291588.1"
                     /locus_tag="FOF52_RS02525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02525"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_248592219.1"
                     /sec_met_domain="Pkinase (E-value: 8.7e-30, bitscore:
                     101.9, seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 2.9e-06, bitscore: 25.4,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVVSGELGTVPYTLVEGADGADEPEEPTQVGGHRIVERIGTGGAA
                     AVYAALDPAGRWTAVKVLHPAVAADAACRKRFAREVALLGTVAGEYTAPLLDADVGAAR
                     PWLAMHYIAGPTVGGHVDAEGPLAGVALLEFAAGLAEAIAAVHRGGIVHRDLKPGNVLL
                     AGDGPRIIDFGIARRCDEDLDAGSGEILGSPGWISPEQFHDRVPGPAADVFAWGGLVAY
                     AATGRRPFGAGTLRQTAARVLNGEADLHGTPGLLRPWVEAALHTDPDRRPASAELAEAI
                     GGLAGPRRRPPQASSSWAWISSR"
     gene            complement(8257..9993)
                     /locus_tag="FOF52_RS02530"
                     /old_locus_tag="FOF52_02530"
     CDS             complement(8257..9993)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291589.1"
                     /locus_tag="FOF52_RS02530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02530"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_248592220.1"
                     /transl_table=11
                     /translation="MSSSPPRSLRLLAAHLWPHRRAVGCGALLGLLGGVGTLAEPLAAM
                     AVVDALADGSPLGGLLALLTALVVGGALVAGLSSYVLQRTAESMVAAARDRLVSHILLL
                     RVPELDRLKPGDLLSRVTSDTAHIRSAAGQALVDSGSALLVAVGSIVLMAWIDLPLLLV
                     CLAVIAVIGAGSVLLMPPIRRANERSQRAVGEVGALLERSLGAFRTLKASGAEQRETVS
                     ARAAVRRAWRDGVRAAAWTAATHVAGVVTSQAAFLVVLGVGGARVATGALDVSGLIAFL
                     LYLMRLTGFVVQLAQGVSGLQSGLAAMRRIDEVERLPVERRGAAPRRGAQAPAPASVSF
                     TGVSFRYRDDAPPVLRDVTLDVPAGGLTALVGPSGAGKTTLFSLVERFYDPAEGTVSLD
                     GVDVRDLPLAHLRSMIGYVEQDAPILSGTLRDNLCYAAPDADEAEVRRVVALTRLTALV
                     ERLPDGLDTEVGHRGTTLSGGERQRVAVARALLRRPRLLLLDEATSQLDAANETALREV
                     IADVARTTTVMVIAHRLSTVVDADQIAVVEGGRVRAVGRHADLLRCDDLYRELIQAQLL
                     DA"
     gene            complement(10001..10417)
                     /locus_tag="FOF52_RS02535"
                     /old_locus_tag="FOF52_02535"
     CDS             complement(10001..10417)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291590.1"
                     /locus_tag="FOF52_RS02535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02535"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_248592221.1"
                     /sec_met_domain="PF13471 (E-value: 8.5e-27, bitscore: 91.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSENVVLQRSDVRLTVREKWAARCAVGLARLLERRSPERISATLR
                     RIRGSARPATYAEAKAARDAVLAVSLRCSGLGACLQRSLAVALLCRMRGTWAVWCVGVP
                     RRPPFAGHAWVEAEGRLVEEGVGYDYFSRLITVD"
     gene            complement(10414..10686)
                     /locus_tag="FOF52_RS02540"
                     /old_locus_tag="FOF52_02540"
     CDS             complement(10414..10686)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291591.1"
                     /locus_tag="FOF52_RS02540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02540"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_248592222.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 5.6e-26,
                     bitscore: 88.4, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 3.3e-09,
                     bitscore: 34.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.6e-15, bitscore: 54.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METTGAEFRLRPDVSAAETDYGMVLLDGRSGEYWELNDTAAQIVQ
                     RLLDGQAPADVAQFLVGEYEVEQATAERDVAALVTGLLESGMVLR"
     aSDomain        complement(10423..10665)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FOF52_RS02540_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="3.70E-28"
                     /identifier="RREFam002.1"
                     /label="FOF52_RS02540"
                     /locus_tag="FOF52_RS02540"
                     /protein_end="88"
                     /protein_start="7"
                     /score="88.4"
                     /tool="antismash"
                     /translation="FRLRPDVSAAETDYGMVLLDGRSGEYWELNDTAAQIVQRLLDGQA
                     PADVAQFLVGEYEVEQATAERDVAALVTGLLESGMV"
     aSDomain        complement(10501..10665)
                     /aSDomain="Lasso_Fused_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing fused peptidase in a lasso
                     peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FOF52_RS02540_Lasso_Fused_RRE.1"
                     /evalue="2.20E-11"
                     /identifier="RREFam003.1"
                     /label="FOF52_RS02540"
                     /locus_tag="FOF52_RS02540"
                     /protein_end="62"
                     /protein_start="7"
                     /score="34.7"
                     /tool="antismash"
                     /translation="FRLRPDVSAAETDYGMVLLDGRSGEYWELNDTAAQIVQRLLDGQA
                     PADVAQFLVG"
     gene            complement(10667..12502)
                     /locus_tag="FOF52_RS02545"
                     /old_locus_tag="FOF52_02545"
     CDS             complement(10667..12502)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291592.1"
                     /locus_tag="FOF52_RS02545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02545"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_248592223.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.7e-33, bitscore:
                     114.7, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVGRISPYFAVFPDEDALGRAADRLPAAQCLATHRSGRPWIVGSL
                     PDDQFLLVEAGERRLAVIGRCAVGPERLRAELERLDGLAGLDRVAHALPGSFHLVAVVG
                     DRMRVQGSASGLRRVFHARVGAARVAADRSDVLAGLSGVSPDPDVLALRLFNGLPHPLT
                     ETSVWPGVDPVPAWHYLDLGLHGGDHRVVRWWRPPEPELDIAAGAPLLRAALTDAVDAR
                     THGGQVVSADLSGGLDSTPLCALASSGPAKVVALTLSSDLDTDDDLHWARIALRSFPSV
                     DHVVFSTRDLPDFYAGLDGEELPLLDEPSVAVLSAPRVLGRLRLAHRHGARLHMDGLGG
                     DQLLCGTPTLYHDLLRSRPLTALRLVRGHRLLLGLPLSETVSSLADRRDLRAWFAATRR
                     LVATGEAPRNALFGWDSLPSCGPWLTAEARERVLARFDAAAETLEPLAPTRGRHADLAT
                     VRSTGRDLRLIHQMSVDGLPSAESPFLDDRVVEACLRVRPEGRSTPFEFKPLMKAAVSD
                     LLPEEFLHRRSKTDGTPLAAEGFAEQRDRIVQIWRESRLAELGLIDPEPLVEQVMRPYS
                     FHGPNWGMELTLTVELWLRSRERVLQGANGGDNRS"
     gene            complement(12540..12683)
                     /locus_tag="FOF52_RS02550"
                     /old_locus_tag="FOF52_02550"
     CDS             complement(12540..12683)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FOF52_RS02550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FOF52_02550"
                     /product="hypothetical protein"
                     /protein_id="WP_248592224.1"
                     /transl_table=11
                     /translation="MQEKKPTQRKKYTAPQIAKAGGFKESTGWYTANSGVEIYLIFPRW
                     LR"
     misc_feature    12701..12712
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 14.94"
                     /tool="antismash"
     misc_feature    12768..12780
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.62"
                     /tool="antismash"
     misc_feature    12812..12825
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.85"
                     /tool="antismash"
     misc_feature    complement(13126..13144)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.79"
                     /tool="antismash"
     misc_feature    complement(13129..13144)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.82"
                     /tool="antismash"
     misc_feature    13137..13151
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.78"
                     /tool="antismash"
     misc_feature    complement(13191..13205)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.33"
                     /tool="antismash"
     misc_feature    13258..13271
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.49"
                     /tool="antismash"
     misc_feature    complement(13259..13272)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 19.59"
                     /tool="antismash"
     misc_feature    13259..13273
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.48"
                     /tool="antismash"
     misc_feature    complement(13260..13273)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.15"
                     /tool="antismash"
     gene            13387..13962
                     /locus_tag="FOF52_RS02555"
                     /old_locus_tag="FOF52_02555"
     CDS             13387..13962
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291593.1"
                     /locus_tag="FOF52_RS02555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02555"
                     /product="hypothetical protein"
                     /protein_id="WP_248592225.1"
                     /transl_table=11
                     /translation="MGRKLAVGTVVFGGITLLGLPLGLLWWLIAPRPEATVTSRGLAYY
                     PLSQTWFAVDGHYSLMMLVAGLAVGYVCYLVQQRVSHRHRLDLRLPTLLGVAAGTAAGS
                     LVAWGVGVGLDLRAADDALLLAGPGDVVRTGLALRAHSALLLWPFSAVLQYGLFEALTL
                     WQAEPDDGAEESARTGAAAGSGGRPGRD"
     gene            complement(13987..14697)
                     /locus_tag="FOF52_RS02560"
                     /old_locus_tag="FOF52_02560"
     CDS             complement(13987..14697)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013154214.1"
                     /locus_tag="FOF52_RS02560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02560"
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_248592226.1"
                     /transl_table=11
                     /translation="MVTAAMPWDWRRGPRRVGRRTWLFAQWAGGGGPHRRSGFGPPVPP
                     PPPNGPWGMPPAGPFGAHHGPFGLFGGRRGGRGPRARRGDVRTGILLLLAEKPMSGYEI
                     IKEGRERSNGAWRPSPGSVYPMLQQLEDEGLVAPAAGGEGRRRPYELTEEGHAHVAEHA
                     AELTPPWESAAREYEEEHAQHAELASLAAQLAAAAAQVSHVGTAEQVERAKRLLAEARR
                     GVYRILAEDEDGAR"
     misc_feature    complement(14734..14754)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 24.85"
                     /tool="antismash"
     gene            complement(14823..15959)
                     /locus_tag="FOF52_RS02565"
                     /old_locus_tag="FOF52_02565"
     CDS             complement(14823..15959)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291595.1"
                     /locus_tag="FOF52_RS02565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02565"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_248592227.1"
                     /transl_table=11
                     /translation="MVAAIVLGTALHYLLVTFCYVVTRVRYSRVRAAGPLRPAVGPEDL
                     DPYELALLAGGRTRVGEVAVAELFLTGRLTAWGPGMVAGVPGRCGASPAPLSDAPFVRA
                     LSARLVAGRPLSVDRLASAATCGDAITAALWRLRRLGLFLAAGRLLGVVALRRAAWLSQ
                     VALGAVGVLAAGFVVGWTVSSAPVDRSPVPLLLVLLLGYPFLLHVGFRAVGGAAGAVGA
                     AALVVAVSAVAGGSAGELLAAVVPFGGWFAAYAVYRGTGGRLGPRTVAGDVLLAEARAE
                     VAVRCDGGALLRVTAVAGFRGLRTGSVPATGAPRLARLAAFAAACGRSFGSADRGVGGD
                     FGWDGARGDWTVHGEVLPLPSSAPRGGRDRRGPANGRS"
     misc_feature    15992..16010
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.96"
                     /tool="antismash"
     misc_feature    complement(16035..16050)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
     gene            complement(16089..16568)
                     /gene="ybaK"
                     /locus_tag="FOF52_RS02570"
                     /old_locus_tag="FOF52_02570"
     CDS             complement(16089..16568)
                     /GO_function="GO:0002161 - aminoacyl-tRNA editing activity
                     [Evidence IEA]"
                     /GO_process="GO:0043039 - tRNA aminoacylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ybaK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630700.1"
                     /locus_tag="FOF52_RS02570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02570"
                     /product="Cys-tRNA(Pro) deacylase"
                     /protein_id="WP_248592228.1"
                     /transl_table=11
                     /translation="MGGRGTPATVAAARGGIAFTLHTYTVTGTGSYGEEAAGALGVPPE
                     RMFKTLVAEVDGTLTVGVVPVAGRLDLKALAAAVGGRRARLADPAAAERATGYVRGGIS
                     PLGQRRRLRTVVDSSAADHETVYVSAGRRGLQMEVAPADLVRLTGAVTASIAARD"
     gene            complement(16598..17275)
                     /locus_tag="FOF52_RS02575"
                     /old_locus_tag="FOF52_02575"
     CDS             complement(16598..17275)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017616936.1"
                     /locus_tag="FOF52_RS02575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02575"
                     /product="LON peptidase substrate-binding domain-containing
                     protein"
                     /protein_id="WP_248592229.1"
                     /transl_table=11
                     /translation="MSTTLPLFPLGSVLFPGLTMALHVFEDRYLRLVDDLLDLPADRPR
                     RFGVVGIKLGREVGEGATHQIAEVGCTAEISTVQHRSDSGLDLVVTGVERFRVVEPVEP
                     DEETPYRRARVAPLAEEVGEDAGAWWERTARHFTVYLERLDRIGVVVAAGAELPAEPVE
                     SSYTVADAMVLDMSDKQALLEAPSAAERLALAVDLLRRENRVLSAFRLLPAGRFPHQVI
                     NLN"
     gene            complement(17325..17888)
                     /locus_tag="FOF52_RS02580"
                     /old_locus_tag="FOF52_02580"
     CDS             complement(17325..17888)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017608013.1"
                     /locus_tag="FOF52_RS02580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02580"
                     /product="ferritin"
                     /protein_id="WP_248592230.1"
                     /transl_table=11
                     /translation="MTTDVHGSEHGLSKFHQLLVDQLRHEFTASQQYVALAAWFDGRDL
                     PRLAGFFYRQALEERDHAMMILRFLLDSGVPVTVPGTDAVRNDFDTPRDPVALALRQER
                     AVTDQFHRLVAAAREENDYTGEQFLQWFLREQVEEVATMSTLLAVVDRASGDLFDVETF
                     VARDLRPAEAVEAGAPETAGPAAS"
     gene            18003..19310
                     /gene="hisD"
                     /locus_tag="FOF52_RS02585"
                     /old_locus_tag="FOF52_02585"
     CDS             18003..19310
                     /EC_number="1.1.1.23"
                     /GO_function="GO:0004399 - histidinol dehydrogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291597.1"
                     /locus_tag="FOF52_RS02585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02585"
                     /product="histidinol dehydrogenase"
                     /protein_id="WP_248592231.1"
                     /transl_table=11
                     /translation="MISRIDLRGNPADPRESLPRAETDVASAVEKVRPICEDVRHRGVE
                     ALIELGERFDGVRPAHLRVPADALDTALAELDPAVRAALEESIRRARLVHRDQRRTDTT
                     TRVVPGGTVTERWVPVDRVGLYVPGGRAVYPSSVVMNVVPAQEAGVPSLAVASPPQADF
                     GGLPHPTILAACALLGVDEVYAVGGAQAVAMFAYGAGECARADMVTGPGNIWVAAAKRL
                     LKGIIGIDSEAGPTEIAILADDTADPGYVAVDLISQAEHDVVAASVLVTPSERLAAGVE
                     AELAARVPATKHSDRVAQALGGPQSGIVLVDDLDHGLDVVNAYAPEHLEVMTADARSVA
                     ARVRNAGAIFVGDHSPVSLGDYCAGSNHVLPTGGCACHSSGLSVQSFLRGIHVVEYDRA
                     ALAEVAHHVVALAQAEDLPAHGEAVTARIPLEEQQT"
     gene            19307..20410
                     /locus_tag="FOF52_RS02590"
                     /old_locus_tag="FOF52_02590"
     CDS             19307..20410
                     /EC_number="2.6.1.9"
                     /GO_function="GO:0004400 - histidinol-phosphate
                     transaminase activity [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (36-356). E-value:
                     1.6e-63. Score: 207.0. Matches aSDomain:
                     nrpspksdomains_FOF52_RS02590_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291598.1"
                     /locus_tag="FOF52_RS02590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02590"
                     /product="histidinol-phosphate transaminase"
                     /protein_id="WP_248592232.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.2e-61, bitscore:
                     206.9, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDFGHTDFGLEDLPLRDDLRGQSPYGAPQLTVRAVLNTNENPYP
                     PSPRLAEAIGRAAAEAAAGLNRYPDRDAVDLRRALADHLGHGLDAANVWAANGSNEILQ
                     QILQAFGGPDRTAVGFEPSYSMHPIIARGTATGWVSVPRTARFEVDAADAVAAVKEHQP
                     SVVFLTSPNNPTGTALPLETVEAVAAAAPGVVVVDEAYAEFRREGTPSALSLLPIHPNV
                     IVSRTMSKAFALAGARLGYLAAHPAVVDALQLVRLPYHLSAVTQAVARTALEYADELLG
                     AVETLRAERDALVDWLRAHDFEVADSDANFVLFGRLPDRSEVFRKLLEQGVLIREVGPP
                     EWLRVTVGTPEEMALFRDALLTATGRA"
     aSDomain        19415..20374
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FOF52_RS02590_Aminotran_1_2.1"
                     /evalue="1.60E-63"
                     /label="FOF52_RS02590_Aminotran_1_2.1"
                     /locus_tag="FOF52_RS02590"
                     /protein_end="356"
                     /protein_start="36"
                     /score="207.0"
                     /tool="antismash"
                     /translation="LNTNENPYPPSPRLAEAIGRAAAEAAAGLNRYPDRDAVDLRRALA
                     DHLGHGLDAANVWAANGSNEILQQILQAFGGPDRTAVGFEPSYSMHPIIARGTATGWVS
                     VPRTARFEVDAADAVAAVKEHQPSVVFLTSPNNPTGTALPLETVEAVAAAAPGVVVVDE
                     AYAEFRREGTPSALSLLPIHPNVIVSRTMSKAFALAGARLGYLAAHPAVVDALQLVRLP
                     YHLSAVTQAVARTALEYADELLGAVETLRAERDALVDWLRAHDFEVADSDANFVLFGRL
                     PDRSEVFRKLLEQGVLIREVGPPEWLRVTVGTPEEMALF"
     gene            20480..21073
                     /gene="hisB"
                     /locus_tag="FOF52_RS02595"
                     /old_locus_tag="FOF52_02595"
     CDS             20480..21073
                     /EC_number="4.2.1.19"
                     /GO_function="GO:0004424 - imidazoleglycerol-phosphate
                     dehydratase activity [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018848720.1"
                     /locus_tag="FOF52_RS02595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02595"
                     /product="imidazoleglycerol-phosphate dehydratase HisB"
                     /protein_id="WP_248592233.1"
                     /transl_table=11
                     /translation="MSRIGRVERATNETKVLVEINLDGTGAADISTGVGFYDHMLHQIA
                     KHGLFDLTVHTEGDLHIDSHHTMEDTALALGAAFREALGDKTGIRRFADVKVPLDEALA
                     EVTVDVSGRPYLVHSEPAGMAPVIGRDYDTTMTRHIFESFVAQARVALHVHVPYGRNAH
                     HIVECQFKALARALRFACERDPRVSGVPSTKGAL"
     misc_feature    20528..20541
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.11"
                     /tool="antismash"
     gene            21070..21231
                     /locus_tag="FOF52_RS02600"
                     /old_locus_tag="FOF52_02600"
     CDS             21070..21231
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291600.1"
                     /locus_tag="FOF52_RS02600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02600"
                     /product="hypothetical protein"
                     /protein_id="WP_248592234.1"
                     /transl_table=11
                     /translation="MSTTVLGVLLIGLGGLLFGGTLSLWKTNKAIAVGLAACAVLALAA
                     GVLRLGYF"
     gene            21260..21895
                     /gene="hisH"
                     /locus_tag="FOF52_RS02605"
                     /old_locus_tag="FOF52_02605"
     CDS             21260..21895
                     /EC_number="4.3.2.10"
                     /GO_function="GO:0000107 - imidazoleglycerol-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0016884 - carbon-nitrogen ligase activity,
                     with glutamine as amido-N-donor [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291601.1"
                     /locus_tag="FOF52_RS02605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02605"
                     /product="imidazole glycerol phosphate synthase subunit
                     HisH"
                     /protein_id="WP_248592235.1"
                     /transl_table=11
                     /translation="MQPHVVILDYGSGNLRSAQRAVERVGARVTVTGDPHTALEADGLV
                     VPGVGAFETCMRGLRAVRGDRVIGKRLAGGRPVLGICVGMQVLFDRGVEHGVTTEGCGE
                     WPGTVDRLDAPVVPHMGWNTVDTPAGSEMFAGLDEDTRFYFVHSYGVRAWEMEATSPHL
                     KPPLVTWSTHGSPFVAAVENGPLWATQFHPEKSGDAGARLLANWIATL"
     misc_feature    complement(22335..22350)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.58"
                     /tool="antismash"
ORIGIN
        1 ttcgaccggc acgccgccat cccggtgctg cgccaccccg actgggacct ggcggaggtc
       61 gaggcgtccc cggaccaggg agaggtgctg gtggagtacc gccacgtcaa gagggcggac
      121 gcggagccgc tcaccctgta cgcctaccgt cccgaggcgg cggactggtg gtcgtgggac
      181 gagatcgagg tgggggaggg ggacgaggcc ctcagggacg acgggttcgt cctgctgcgc
      241 gacccccgca acggccccac cctctacctg gacctcgccc tgtcgacccg ggtccaggtc
      301 gtctggcgcg gcgccacgca ggaggagctg gccgccctgg ccggatacat ctgggccgcc
      361 accgacatcg aacgggccga actgcgccgc gaggtcggtc cgccccgccg cgagtaggcg
      421 gcggcggagc ggttcccctt cggggccgcc gccgtttcca cggcttcgtc ccggccgcgg
      481 acgaaacgga ttcccgcggt ggctccgttc cgccgccggt cgccgccaag ggacgcgctc
      541 cggccgcggg agcggaaatc gcagaggcgc accgggcacg cggaacgcaa tggaatctcc
      601 cggtggccgc ctcggccgcc ccgggaaccc gtagagcggg aaccctgccg ggacagcgcg
      661 gtgcgccccc tcccggagac ggtccgggcc gttccgtacc gcgggccgaa ttcgccgggt
      721 gaagggtggg aaaaaggacg atattcgttt tctgctgttg tctctcggga ttggcgctgt
      781 tactctctga aaaatttttg ctctccgggc gagagccacc gagagggaaa gcggtaaagc
      841 tcaccatgcc tgacagagac gaggaaatcg gtgggggcgg cggtcaggcc gtctacgtcg
      901 tcgacagcgg tgagacagcg gtccgggggg agctgctgac cgctgtggag gtgggggacc
      961 tggacggtct gctggcgggc gagaccgagg agcacgccgc cccggaggcg gtgctccggg
     1021 cgttcgagct ctaccaggag aacctggggt gacgtccgcc ggggagacgg gtccgcggcg
     1081 agcccggcgg ggcggacctc cgggctccgg tatcggtcgg cgcggcccgc tcagcccact
     1141 ccgagcgccc gcaggcccgc cgtggtcgcc gcggccacca cgagcaccag caggaaggga
     1201 gcacgcagca gcagggccac caccgcggcg gccataccgc ccagccgggg caggtcgacg
     1261 accaggtggt tgccctcggc cacgctctgc agggcgatga gcgcggccag cagcgccacc
     1321 gggaccgccg tcgcgaaacg gcgcaccagc ggtcgttcca gcagggcgcg cggagcggcc
     1381 aggcccgcgt acttgagcag gtagcagccg agtccggtga ccaggacggc gagccacagc
     1441 atcacgcccc gctcccctcc gacccggtct tctccccgtc ctcgcccagc gcgaccaggg
     1501 ccgcgatcga cgccagcagc accggcacgc ccggcggcag cagcggggtg gcggccagcg
     1561 cgatcgccgc gcccagcagc gccacgacca gggtgcggcc gccctctttc agccgcggcc
     1621 acagcagggc caggaaggtc gccggaccca ccacgtccag gccgaacgtg gtggggtcgc
     1681 cgatgctctc ggtggcgacc gcgccgagca gcgtggtggc gttccacagg acgaacaggg
     1741 tgacgaaggt ggtggtgaac cccgcgcgga cgtccgagcg tccgtgctgg gccagcgcca
     1801 ccgcggtggt ctcgtcgatc accccctgcg cggcgagcgc ccgcccgggg ccgcgccagc
     1861 cgagcagttc gctcagccgc agcccgtaga gcgtgttgcg gaagccgagc agcagcgcgc
     1921 ccaccgcccc cgcgatgagg ttgccgccgc ccgcgaccac gccgaccagg gcgaactggg
     1981 aggccccggt gaacgccacc aggctgagca cgcacgcctg cgccaccgac aggccggagg
     2041 tgaccgcggt ggtgccgaag gcgagtccgg agaatccgac ggcgaggccc acaccgaatc
     2101 cgtcacggac gggcggcctg cgggccaggg aggacagacg gggaagcagg gctggacggt
     2161 tcacgtcagc gaacctagcc gatccgctgt cccgatcggg aagcggaccg gactatcgtc
     2221 gtggcgtgct ggacatcgtt gtggcccgga gtgagcggga gcgtgcggcg gtcttcgtcc
     2281 tgcggggcgc ggtcttcgtc gccgagcagg gcgtgcccgt cgaggaggag tgggacgagc
     2341 gcgacgccgt ggccgaccac ttcctggcac tgcgggacgg tgtcccggcg gggaccgggc
     2401 ggctggtcgt ccacggtgac gagggggtgc tggggcggct ggcggtgctg cgccggttcc
     2461 gcggggcggg cgtgggggcg gcgctggtgg ccgccatcga ggagcgggcc gtgcggcggg
     2521 ggctggtcgc ggtggagctg cacgcccaga cccacgcgct ggggttctac gagcgcctgg
     2581 ggtacaccgc ctacgggccg gagttcgagg aggcgggcat cgcgcaccgg agcatgcgca
     2641 aggagttggc gcggcgcggc gggtgacgcg gggccgggca gcgtggccaa gataacccga
     2701 atttcgctcg gttttccggc ggtcgaggtg gcccgtccac ttactgacaa gtaacatttc
     2761 gggtggtcgc ggcaccccgc gccgagttga tcttcacgaa gggctgacga cattcccatg
     2821 acggtcgatg cacacccgat cgcggagctg cccaacccgg ccgactacgg gttcaccgtg
     2881 gtcgaccccc acgagcttcc cgccgagctg ctgaccctgg tcgaccgggt gcgcgaactg
     2941 gtcgacgccg tcgcgcacac cgacgccgac cccgccgaac tggccgccgc gagccgcacg
     3001 gtcgacgagc tcaccgaacg cctcggcgcc cggcgccgcc ccgtcggcgc catggtgcgc
     3061 cagacctggg agggcggccg cgtcgactac aacacgctcg ccaacgtggt gagcggcccg
     3121 gccaacccgg tcgcgccgct gcggaacctg cgcgcgacgg acgacggcct gtacggcgag
     3181 gtcaccctcg acagcttcta cgaggggccg cccggattcg tgcacggcgg atgggtcgcg
     3241 gccctgctcg accaggtgct cggcgaggcc accgcggtct tcggccgcgt ctgcatgacc
     3301 ggcaacctca ccgtcgacta ccgccggccc acccccctca acaccccgct gaccgtctcc
     3361 tcccgcatca ccggcgtgga gcgccgcaag gtgttcgtct ccggggagat ccgctgcgac
     3421 gggaaggtca ccgccgaggg cagcgcgatc atggtgcagc tggaggctcc cccggcgtag
     3481 cggagggagc cgcaccgggt ccggtgaccg cgtagcgcag gatggtgcgc agtcgctccg
     3541 gcgccgtccg cgccgggttc gacaggtaga tctcgtggtg ccggccgcag atccggtagc
     3601 cgtgcgcgtc ggcgaaggac agcagccgct cgaccgcggg ccactcctgc gcgtacggtc
     3661 cggtgtgcag gacctggacg ctggggccct cggcgaactc ccgcaactcg acccggtcca
     3721 cggcggtgga gggcctcctg cgggccgcca cggccagggc gtcggcgacc cgtccggcgt
     3781 ccgcctgggg cggctgcatg atcatcatgg tccagtgcca cgcgtcccgg tcctccatgg
     3841 gcaggtcgtg gcgtcccggg gcccaccaca gcccctccag gggcatgacg gggtactcca
     3901 ccaccgcgtc gtgcttcaac gcgaaccgca gcgcgtagga ggtcgcgtac agcgcctcga
     3961 cggccctgcg gtaggccggc cccgaggggt cgccgacccc gtcgaccgcg aggaaccgca
     4021 gcgggggcac gtccacgacc gcgggggccg cggtggccga gtacaggttc cggtactgct
     4081 tcttgaagtc ggtcctcggc acggtggtca atgtcactcc tcctcgtgca gtgggacgac
     4141 gatccgggtc cgcagccggg ccgggtcgct cgtcgcggga tcgtccaggt acgcctcgta
     4201 gaccgtgccg cgggggcgca gcgcgcgctc gtggatccag gcgaacaccg cctggtaggt
     4261 cagggtcagc tgttcgtagg ggccggtgtg caccgcggtc gcggcgagcc cgggcggcag
     4321 gtgctccacc cgggtgccgg ggaccggggc ggcggtcggc gcctccaccc cggcggccac
     4381 ggtcatccgc tcccgcaggt cgacggggaa acacccccac agcggcgggg tccaggagag
     4441 gtccgccgcg gccgacgtca cctgggcgac gcagcggctc acggccgcgc cgatctcctc
     4501 cggcgcgcac tcggccgcgc tgacgagcag gcgccgggcg ggttcccggg acagcgcgac
     4561 ctcctggtgc agcaggccgt cgctcaccag ccgctccagc gcctgccagg cccgccgctg
     4621 ggccgccatg cgctcctcca gccggcgctg ctcggcgcgc agcgcggcct cccgggcgtc
     4681 ccggtcgctg gcgaggaccc gggtgatcac cgggagcggg atgtcgaacc cgcgcagcag
     4741 ggcgatggtc atcgcgtcgc ggacctggtc gcgaccgtag taccggtagc cggtggcggg
     4801 gtcgacgtgc cggggcggca gcagccccag ttcgtcgtag tggcgcagcc gcttgacgct
     4861 caaccggcac agccgggcga aggcgccgat cgacatcagc tcttcggaca tgaggccatc
     4921 ctgccccctc ccctcgtggg agagtccagt gccgcggccc cggggcgcac ggcgcaccgc
     4981 cgcggcgtgt cgtgcgccag ggccgacagg ggcggcggga cggccgttcc ggtgcgggcc
     5041 ggggcgcgcc cgccccggag gagaaccgct cgtcccgggc gggcgggggc actaggctct
     5101 gaccgccgac acaggaggtg ggacgaaatc ccacgggagc cccgggtggt ggttgatgac
     5161 gcagacagga gagcgggcgg gtgggaccgc tcccgccgac tcccgggtcc gcgggatcca
     5221 acggcgggtc ctgaccgtgc tggtggccgc ccaggccgtc ggcggaatcg gggtgggggc
     5281 ctcgctgacg gtcggcggaa tcgtcgcccg ggacatcacc gggaccgagg cctgggccgg
     5341 aacggccacc accatgttca ccctgggggc ggcggtgttc gcgctgccgc tggccggagc
     5401 ggcggcccgc cggggccggc gcgtcaccct cggcgcgggc tggctgttcg cggccggagg
     5461 cggggccgtc gccgtggccg gcgcgcaagc cggactgttt tccgtcttcc tgctcggcat
     5521 ggtcctgttc ggcgccgggg gagccgtcaa cctgcagtcc cggtacgccg ccgccgacct
     5581 ggccgccgac cgcacccggg gccgtgacct gtcggtcgtg gtgtgggcca ccacgatcgg
     5641 ctccgtcctc ggccccaacc tcaccgaacc gggagcggtc gtcgccggat ggctcggcct
     5701 gcgtccgctg ctgggcgtct tcgccatctc cgtggccgcg ttcacggtcg cgggcctgct
     5761 gatcctcgcc ctgatgcgcc ccgacccgct gctgaccgcc cgcgccctcg ccccttcccc
     5821 cgctcccgcc gcggccgcgc gcggcccacg gtccggcgcg ctggccgcgc tgaggggggc
     5881 gccgcgggcc gtgctggcgc tggtcgcggt cgccagcggg caggccgtca tgatcatggt
     5941 gatgaccatg acgccggtgc acatggagcg cggcggggcc gacctcacca ccgtcggcct
     6001 caccatcagc ctgcacgtcg cgggcatgta cgcgctgtcc ccgctggtgg gctggctcgc
     6061 cgaccgcctc ggccgggttc ccgtgctgct ggccggccag ggggtcctgc tcgccgccgc
     6121 ggccgtgtcc ggcctggccg gccacggcac cgcgatgatc accgtcggtc tggtcctgct
     6181 gggggtgggc tggtccctcg gactggtctc cggttccgcg ctgctggccg agtcgctgcc
     6241 gcccgaacgg cgtcccgccg tgcaagggct gtccgacctg ctgatgaacg cgagcggggc
     6301 cgccagcgga gccctctccg ggattctgct ggcgcacctg gggtacggcg gcctcaacgc
     6361 ggtcgccgcc gcactcaccg ccccggtgct cgggtgggcg gtgttcgccc tgctgggcac
     6421 agtccggaag gaagccacgt gaccgaacgc atcctcctca ccggcgcggg gggccggatc
     6481 ggcaccctgc tgcgcccccg gatgacccgc cccggacgtg tcctgcggct gcacgaccgg
     6541 cgccccctcg aaccgggccc gggagtggag gtcgtcaccg gcgacgccac cgacctggac
     6601 gccgtgaccg aggcgatgga cggggtggac gccgtggtcc acctggccgc ccgcagcacc
     6661 gaggcggcct gggaggagat cctgcacacc aacatccacg gcggctacgt cgtgctggag
     6721 gcggcccggc gcgccggggt cacgcgactg gtgctggcca gttccaacca cgccgtggga
     6781 ttccaccccc gttccgccgg gaccgcgccc gactacctgt tcccccgccc cgacacctac
     6841 tacggggtca gcaaggtcac cctggaggcg ctgggcagcc tgtacgccga ccgctacggc
     6901 atggacgtcg tgtgcctgcg catcggctac tgcggtccgc gcccgctcgg ccggcacggc
     6961 ctgggcacct ggctgtcccc cgacgactgc gcgaacctgg tggagtcctg cctgagcgcc
     7021 cccgcccccg gattccgcgt ggtgtggggc gtctccgaca acacccggcg ctggtggtcc
     7081 ctggacgagg cccgctcgct ggggtacacg ccgcgcgacg acgccgaggt gttcgccccc
     7141 gagtgggagg ccggcgtccc cgccgaggag ctggaccccg agggccccac cgtcggcggg
     7201 aacttctgcg gcccccacct ggacgccgac cgcctgcgct gtgggggcgg aacgtgaccg
     7261 tttgaccctc caccgagtgt ttgccggttt tctccgagcg cgcgtgtgag aacagtgggc
     7321 ggtttgggaa gtggcggccg gtaggtgagc acctgactgc tttgcgttcg gggggacttt
     7381 catggtggtt tccggtgagc tgggcacggt tccctacacc ctggtggaag gcgcggacgg
     7441 cgcagacgaa cccgaggagc cgacgcaggt cggaggacac cggatcgtcg aacggatcgg
     7501 aaccggaggt gccgcggcgg tctacgccgc actcgacccc gcggggcggt ggacggcggt
     7561 caaggtcctg caccccgcgg tcgccgccga cgcggcctgc cggaagcggt tcgcccggga
     7621 ggtcgccctg ctcggcacgg tggccggcga gtacaccgcc ccgctgctcg acgccgacgt
     7681 cggtgcggca cggccctggc tggccatgca ctacatcgcg ggccccaccg tcggcggcca
     7741 tgtcgacgcc gaggggccgc tggccggggt ggcgctgctg gagttcgccg ccggactggc
     7801 cgaggcgatc gcggccgtgc accgcggcgg catcgtgcac cgcgacctca aacccggcaa
     7861 cgtgctgctg gccggggacg gtccccggat catcgacttc ggcatcgccc gcaggtgcga
     7921 cgaggacctc gacgccggct ccggggagat cctggggtct cccggatgga tcagccccga
     7981 gcagttccac gaccgcgttc ccggccccgc cgccgacgtc ttcgcctggg gcgggctggt
     8041 cgcctacgcc gcgaccgggc ggcgtccctt cggggcgggc acgctgcggc agaccgcggc
     8101 gcgggtcctc aacggcgagg ccgacctgca cggcaccccc ggcctcctgc gcccctgggt
     8161 ggaggcggca ctgcacaccg accccgaccg ccggcccgcg tcggcggagc tggccgaggc
     8221 gatcggcgga ctcgccggcc cgcggcgccg gccgcctcag gcgtccagca gttgggcctg
     8281 gatcagctcc cggtagaggt cgtcgcagcg cagcaggtcg gcgtggcggc ccaccgcccg
     8341 gacccggccg ccctcgacga ccgcgatctg gtcggcgtcg accaccgtcg acagccggtg
     8401 cgcaatgacc atgaccgtgg tggtccgcgc gacgtcggcg atcacctcgc gcagcgccgt
     8461 ctcgttggcc gcgtccaact gcgaggtggc ctcgtccagc agcagcaggc ggggacggcg
     8521 cagcagggcc cgggcgaccg ccacccgctg gcgctcgcct cccgacaggg tggtcccgcg
     8581 gtggccgacc tcggtgtcca gcccgtcggg cagccgctcc accagggcgg tcagccgggt
     8641 cagcgccacg acgcggcgca cctccgcctc gtcggcgtcg ggagcggcgt agcagaggtt
     8701 gtcgcgcagg gtgcccgaga ggatgggggc gtcctgctcc acgtagccga tcatggaccg
     8761 caggtgcgcc agcggcaggt cacgcacgtc gacgccgtcg agcgagaccg tgccctccgc
     8821 ggggtcgtag aaccgttcca ccagggagaa cagtgtggtc ttgcccgcac cggaggggcc
     8881 gaccagcgcg gtcagccctc cggcgggcac gtccagcgtc acgtcccgca gcaccggggg
     8941 cgcgtcgtcg cggtagcgga acgacacccc ggtgaaggac accgacgccg gagcgggagc
     9001 ttgggcgccg cgccgggggg ccgctccgcg ccgctccacc ggcagccgct ccacctcgtc
     9061 gatgcggcgc atcgcggcca gcccgctctg cagtccgctg acgccctgcg ccaactgcac
     9121 gacgaagccg gtcagccgca tcaggtagag caggaacgcg atcagtccgg agacgtcgag
     9181 cgcgcccgtg gccacacggg caccgcccac gcccagcacc accaggaacg ccgcctggga
     9241 ggtcacgacc ccggcgacgt gggtggccgc cgtccacgcg gcggcgcgca ccccgtcgcg
     9301 ccaggcgcgc cgcaccgcgg cccgggccga gacggtctcg cgctgctcgg ccccgctggc
     9361 cttgagcgtg cggaacgcgc ccagggagcg ttccaggagc gcgccgacct cgcccaccgc
     9421 ccgctgggag cgttcgttgg cccggcggat cggcggcatc agcagcaccg agcccgcgcc
     9481 gatcaccgcg atcaccgcca ggcagaccag cagcagcggc aggtcgatcc aggccatcag
     9541 cacgatcgag ccgaccgcca cgagcagggc gctgccggag tcgaccagcg cctggccggc
     9601 ggccgaccgg atgtgggcgg tgtcggaggt gacccgggac agcaggtcgc cgggcttgag
     9661 ccggtccagt tcggggacgc gtagcagcag gatgtgggag accaggcggt cgcgggccgc
     9721 ggcgaccatg ctctcggcgg tgcgctgcag cacgtaggag ctcagcccgg cgaccagcgc
     9781 cccgccgacc accagggcgg tgagcagggc cagcagcccg cccagcgggg agccgtcggc
     9841 gagcgcgtcc acgacggcca tggcggccag gggctcggcg agtgtgccga cgccgccgag
     9901 caggcccagc agcgcgccgc agccgacggc cctgcggtgc ggccacaggt gcgcggccag
     9961 cagccgcagg gaacggggag gggaggagga cacggcgggg tcagtccacg gtgatcaggc
    10021 ggctgaagta gtcgtaaccg actccctcct cgaccaggcg gccctcggcc tccacccagg
    10081 cgtgtccggc gaacggcgga cgccggggca cccccacgca ccagaccgcc caggtgccgc
    10141 gcatccggca cagcagcgcc acggccaggg agcgctgcag gcatgccccc aggccggagc
    10201 agcgcaggct caccgcgagc accgcgtcgc gggcggcctt ggcctccgcg taggtcgcgg
    10261 ggcgcgccga gccccggatg cgccgcaggg tcgcgctgat gcgctcgggg gacctgcgct
    10321 ccagcagccg ggccagtccc accgcgcagc gcgcggccca cttctcccgc acggtgagcc
    10381 ggacgtcgct gcgctgcagc accacgttct cgctcatcgc aggaccatcc cgctctccag
    10441 caggccggtg acgagcgcgg cgacgtcgcg ttcggcggtg gcctgctcca cctcgtactc
    10501 gccgaccagg aactgggcga cgtcggcggg cgcctgcccg tccagcagcc gctggacgat
    10561 ctgcgccgcg gtgtcgttga gctcccagta ctcgccgctg cggccgtcca gcagcaccat
    10621 gccgtagtcg gtctcggccg ccgagacgtc cgggcgcagc cggaactcag ctcctgttgt
    10681 ctccaccgtt tgctccctgt aggactcgtt cgcgggaacg cagccacaac tcgacggtga
    10741 gggtcagttc catcccccag ttcggcccgt ggaacgagta cggccgcatg acctgctcca
    10801 ccagcggctc cgggtcgatc aggcccagtt ccgcgagccg ggactcccgc catatctgaa
    10861 ctattcggtc acgctgttcg gcgaacccct ccgcggcgag cggagtcccg tcggtcttgg
    10921 agcggcggtg caggaactcc tcggggagga ggtcggacac ggccgccttc atgaggggtt
    10981 tgaactcgaa cggggtcgac cgcccctcgg ggcgcacccg caggcaggcc tccacgaccc
    11041 ggtcgtcgag gaagggcgac tccgcgctcg gcaggccgtc gacgctcatc tggtggatca
    11101 gccgcaggtc gcggcctgtg gagcggaccg tggccaggtc ggcgtggcgg ccgcgggtgg
    11161 gggcgagcgg ctccagcgtc tcggccgccg cgtcgaagcg ggccaggacg cgctccctgg
    11221 cctcggcggt cagccagggg ccgcagctgg gcagtgagtc ccagccgaac agggcgttgc
    11281 ggggcgcctc cccggtggcc acgaggcgtc gggtggcggc gaaccacgcg cgcaggtcgc
    11341 ggcggtcggc cagggaggag acggtctccg acaggggcag gcccagcagc aggcggtggc
    11401 cgcggaccag ccgcagcgcg gtgagcggac ggctgcgcag caggtcgtgg tagagggtgg
    11461 gggtcccgca cagcagctgg tcgccgccca ggccgtccat gtgcaggcgg gcgccgtgcc
    11521 ggtgggccag ccgcagtcgg cccagcaccc gcggggcgct caggacggcc accgacggct
    11581 cgtccagcag aggcagctcc tccccgtcga gaccggcgta gaagtcgggg aggtcccggg
    11641 tggagaacac gacgtggtcg accgagggga aggagcgcag ggcgatcctc gcccagtgca
    11701 ggtcgtcgtc ggtgtccagg tcgctgctga gggtcagggc gacgaccttc gcgggaccgg
    11761 aggaggccag cgcgcacagc ggggtggagt cgaggccgcc ggacaggtcg gcgctgacca
    11821 cctgtccgcc gtgggtgcgc gcgtccacgg cgtcggtcag ggccgcgcgc agcagcgggg
    11881 ccccggccgc gatgtccagc tccggttcgg ggggccgcca ccaccggacc acccggtggt
    11941 cgccgccgtg caggccgagg tcgaggtagt gccacgcggg aacggggtcg acgccgggcc
    12001 acacggacgt ctcggtgagc gggtgcggca ggccgttgaa cagccgcagg gccaggacgt
    12061 cggggtcggg ggagacgccg gacaggccgg ccaggacgtc ggagcggtcc gcggcgacgc
    12121 gggccgctcc gacccgggcg tggaagaccc ggcgcagtcc cgaggcactg ccctgcacgc
    12181 gcatccggtc gcccaccacc gcgacgaggt ggaagctgcc cggcagggcg tgcgcgaccc
    12241 ggtcgagccc ggccaggccg tcgagccgct caagctcggc gcgcagccgc tcgggcccga
    12301 ccgcgcagcg tccgatcacg gcgaggcgcc gttccccggc ttcgaccagc aggaactggt
    12361 cgtcggggag ggagcccacg atccaggggc gtcccgagcg gtgggtggcc aggcactgcg
    12421 ctgccggaag gcggtcggcc gcacgcccga gagcgtcctc gtcggggaaa acggcgaagt
    12481 aggggctgat acgaccgacc acggaccctc cggaaacgat gttgcgtgca gacgggcgac
    12541 tagcggagcc agcgggggaa gatgaggtag atctcgacgc ccgaattcgc ggtgtaccag
    12601 ccggtggact ccttgaagcc gccggccttg gcgatctgcg gggcggtgta cttcttgcgc
    12661 tgcgtcggct tcttttcctg catgatctgc ctctcctcct gaaaggggta tctgggtgag
    12721 cgctctgggt aactgccggc atgcggcaca aaggctaggg gattccgatg cgtatggcaa
    12781 caggtgcgag aagaaaggat tggtaagacg aatggtgaca taaaagaggg ggtggattgt
    12841 ggtgcgcaag agtggtaaag ggacgtgttc tcgctggtgg gaacggtgtc tttgcggagg
    12901 tgtcgagagg tcgggagggg cggtggcggc ctttcggggg gcggtcggcc gcgggaggtc
    12961 ggaggagtgg ccccgtcgcc gggcggccgc ctccgggggg cgggagtgct ccgggaagcg
    13021 tcccgaccgg tcccgttatt cgcttcggcg ctgctgggaa cgggagtggg cggctgcggt
    13081 ggaggaaggg gcggcgacgg ggggagggcg gagccggaac ggctgaccga ggacgattcg
    13141 caatacgaat agaccacccg gtaggtgggt gggcgaaggg tgtcggcggg agttttcggg
    13201 agatgcggag cgggggaagg ggagcgtccc gggaaagtcg cggtgagcgg ccgctgaatt
    13261 ttggttcaaa atttgatttc ttttcggggc gtcccgctcc cgccgggccg gtgcggcggg
    13321 gagccgtccc ggcaggggat accctctggt gggcacaacg accgagggtg aacgggtggg
    13381 ccggtcatgg ggcgtaaact cgccgtggga acggtggtct tcggcggcat cacactgctc
    13441 ggactgccgc tgggactgct gtggtggctg atcgccccac gccccgaggc gaccgtcacc
    13501 tcccggggac tcgcctacta cccgctctcc cagacctggt tcgccgtcga cggccactac
    13561 tcgctcatga tgctggtcgc cgggctcgcc gtcggctacg tctgctatct cgtccagcag
    13621 cgggtatccc accggcaccg cctggacctg cggctgccca cactgctggg ggtcgccgcc
    13681 ggaaccgcgg cgggctccct cgtcgcctgg ggcgtgggcg tcggactcga cctgcgcgcc
    13741 gcggacgacg ccctcctgct ggccggcccc ggcgacgtcg tccgcaccgg gctggccctg
    13801 cgggcgcaca gcgcgctgct gctgtggccc ttcagcgcgg tcctgcagta cggactgttc
    13861 gaggcgctca ccctgtggca ggcggagccg gacgacgggg cggaggagtc cgcccggacc
    13921 ggggcggccg ccgggagcgg gggccgcccc ggccgggact gaaccggggc acggggccgc
    13981 gcccggtcac cgggccccgt cctcgtcctc ggcgaggatg cggtacacgc ccctgcgcgc
    14041 ctcggccagc aaccgcttgg cccgctcgac ctgctcggcg gtgcccacgt gggagacctg
    14101 ggccgcggcc gccgccagct gtgcggccag ggaggcgagc tcggcgtgct gggcgtgctc
    14161 ctcctcgtac tcccgggcgg cgctctccca gggcggggtc agctccgcgg cgtgctcggc
    14221 gacgtgggcg tgcccctcct cggtcagttc gtaggggcgg cggcgcccct ccccgccggc
    14281 ggcgggggcg accaggccct cgtcctccag ctgctgcagc atcgggtaga cggagccggg
    14341 gctgggccgc cacgcgccgt tgctgcgctc ccggccctcc ttgatgatct cgtagccgct
    14401 catcggtttc tccgccagca gcagcaggat tccggtgcgc acgtcgccgc gccgggcgcg
    14461 cggaccgcgg ccgccgcgac ggccgccgaa gaggccgaac gggccgtggt gggcgccgaa
    14521 cggcccggcg gggggcatcc cccacggtcc gttcggcggc gggggcggca ccgggggccc
    14581 gaacccgcta cggcggtgcg gaccgccccc gcccgcccac tgcgcgaaga gccaggtgcg
    14641 gcgaccgacg cggcgggggc cgcgcctcca gtcccagggc atcgctgcgg tgaccatcgt
    14701 ccctccttcg gaacacttgc gacagtattc gaactatcga catgttgacg atatatcgga
    14761 tactggtcga tggcaatgcc caagtccgcc accggagccg ccccggcggc acgggccccg
    14821 gatcaggaac ggccgttcgc tggcccccgg cggtcccgcc ccccgcgcgg ggcggacgac
    14881 ggcagcggca gcacctcacc gtgcacggtc cagtcgccgc gcgccccgtc ccaaccgaag
    14941 tcaccgccca ccccccggtc cgccgagccg aacgaacgcc cgcacgccgc ggcgaaggcg
    15001 gccagccgcg ccaaccgggg cgcacccgtc gccggaacgc tccccgtgcg cagcccccgg
    15061 aaccccgcca ccgcggtcac ccgcagcagc gccccgccgt cgcaccgcac cgccacctcc
    15121 gcgcgggcct cggccagcag gacgtccccg gccaccgtgc gcggccccag cctgcccccg
    15181 gtaccccggt agaccgcgta cgccgcgaac cacccgccga acggcaccac ggcggccagc
    15241 agctctccgg ccgacccccc ggccaccgcg ctcaccgcca ccaccagcgc cgccgccccc
    15301 accgctcccg cggccccgcc gaccgcccgg aaccccacgt gcagcaggaa ggggtacccc
    15361 agcagcagga ccagcagcag cggaacgggg gagcggtcca ccggagccga cgacaccgtc
    15421 caccccacca cgaaccccgc ggccagcacg cccacggccc ccagagccac ctgggacagc
    15481 cacgccgccc gccggagcgc caccaccccg agcagccgcc ccgccgccag gaacagcccc
    15541 agccggcgca gccgccacaa cgccgcggtg atcgcgtccc cgcacgtcgc cgccgacgcc
    15601 agccggtcca cggacaacgg ccggcccgcc accaggcgcg cggagagcgc ccgtacgaaa
    15661 ggcgcgtccg acagcggggc gggggaggcg ccgcagcgtc cggggacccc cgcgaccatg
    15721 cccggccccc acgcggtgag ccgcccggtg aggaacagtt cggccaccgc gacctcgccc
    15781 acccgcgtcc ggccccccgc gagcagggcg agctcgtagg ggtccaggtc ctccggtccc
    15841 accgcgggcc gcagcggacc ggccgcacgc acccgcgagt agcgcacccg ggtcaccaca
    15901 tagcagaacg tgacgagcag gtagtgcaga gccgtgccca acacgatcgc ggcgaccatc
    15961 gcggactcct cgcctgtcct gtgtcaaccg gatattgatc acagtaggcc ggttcctcgg
    16021 gcctggaaag ggcggtgacc gctccgtgtc cgcggcgtga ccggccgcgg cccgccgccc
    16081 cgccgggctc agtcccgcgc ggcgatcgac gcggtgacgg ccccggtcag ccgcaccagg
    16141 tcggcggggg ccacctccat ctgcaggccc cgcctgcccg cggacacgta caccgtctcg
    16201 tggtccgctg ccgaggagtc caccaccgtc cgcagccgcc tgcgctggcc cagcggactg
    16261 atcccgccgc gcacgtaccc ggtggcgcgc tcggccgcgg cgggatcggc caaccgggcc
    16321 cgccgccctc ccaccgccgc cgccagcgcc ttgaggtcca gccttcccgc caccggcacc
    16381 acccccacgg tcagcgtgcc gtcgacctcg gcgacgaggg tcttgaacat ccgctcgggc
    16441 ggcaccccca gcgccccggc cgcctcctcc ccataggagc ccgtccccgt gaccgtgtag
    16501 gtgtgcaggg tgaacgcgat accgccgcgc gcggccgcga ccgtggccgg agtaccccta
    16561 ccgcccaacg ccgtccgcct tccgtgccgt gaaccggtca gttcaggttg atcacctggt
    16621 gggggaaccg gcccgcgggc agcaggcgga acgccgacag cacccggttc tcccgccgca
    16681 gcaggtcgac ggcgagcgcc aggcgctcgg ccgcggaggg ggcctccagc agcgcctgct
    16741 tgtcggacat gtccaggacc atcgcgtcgg ccaccgtgta ggacgactcc accggctcgg
    16801 cgggcagttc cgcgccggcc gccacgacca ccccgatgcg gtccaggcgt tccaggtaca
    16861 ccgtgaagtg ccgggccgtc cgctcccacc aggccccggc gtcctcgccg acctcctcgg
    16921 ccagcggggc gacccgcgcg cgccggtagg gcgtctcctc gtccggttcc accggctcca
    16981 ccacccggaa ccgctccacg cccgtcacca ccaggtccag accggagtcg gagcggtgct
    17041 gcaccgtgct gatctcggcg gtgcagccga cctcggcgat ctggtgcgtc gccccctccc
    17101 cgacctcgcg gcccagcttg atgccgacca ccccgaagcg gcggggccgg tcggcgggca
    17161 ggtccagcag gtcgtccacc agtctcaggt agcggtcctc gaacacgtgc agggccatgg
    17221 tcagccccgg gaagaggacc gagccgagcg ggaagagcgg cagcgtggtg gacaccgtac
    17281 aagtatgccc gccggcggca cgccgcgccg tcggcggggc cgcgtcagga ggcggccggt
    17341 cccgccgtct ccggggcgcc ggcctccacg gcctccgccg ggcgcaggtc ccgggccacg
    17401 aaggtctcca cgtcgaacag gtcgccactg gcccggtcca cgaccgccag cagcgtcgac
    17461 atcgtggcga cctcctccac ctgctccctg aggaaccact ggaggaactg ctcgccggtg
    17521 tagtcgttct cctcgcgcgc ggccgcgacc agccggtgga actggtcggt gaccgcgcgc
    17581 tcctgccgca gggccagcgc caccgggtcg cgcggcgtgt cgaagtcgtt gcggaccgcg
    17641 tcggtccccg gcaccgtgac cggcacgccg ctgtcgagca ggaagcgcag gatcatcatc
    17701 gcgtggtcgc gctcctccag cgcctggcgg tagaagaacc cggccagccg cggcaggtcc
    17761 cggccgtcga accaggccgc cagcgccacg tactgctgcg aggcggtgaa ctcgtggcgc
    17821 agttggtcga cgaggagctg gtggaacttg gaaagaccgt gctcggaacc gtggacgtcg
    17881 gtagtcatac cgtgccgctg accacaccgg gacgaagtat gcggaaaccg gggagacgcg
    17941 cctgtccaca ggcggcgccg ccccgacggc cccgacgcgg agccgcccct acaatgaggt
    18001 ccgtgatctc ccgaatcgat ctccgaggca accccgctga cccgcgcgag tccctgccgc
    18061 gcgccgagac cgacgtcgcg tccgcggtcg agaaagtccg ccccatctgt gaagacgtgc
    18121 gccatcgcgg ggttgaggcg ctgatcgagc tgggggagcg cttcgacggg gtgcgccccg
    18181 cccacctccg cgtccccgcg gacgccctcg acaccgccct ggccgagctc gacccggccg
    18241 tgcgcgccgc gctggaggag tcgatccgcc gggcccgcct ggtccaccgc gaccagcgcc
    18301 gcaccgacac caccacccgg gtcgtccccg gcggcacggt caccgaacgc tgggtccccg
    18361 tcgaccgggt cgggctgtac gtgcccggcg gccgcgccgt ctacccctcc agcgtcgtca
    18421 tgaacgtcgt ccccgcccag gaggccgggg tgccctccct ggccgtggcc tcgccgccgc
    18481 aggcggactt cggcgggctg ccgcacccca ccatcctggc cgcctgcgcc ctgctcggcg
    18541 tcgacgaggt ctacgccgtg ggcggcgccc aggccgtcgc catgttcgcc tacggcgcgg
    18601 gcgagtgcgc ccgcgccgac atggtcaccg gccccggcaa catctgggtc gccgcggcca
    18661 agcgcctgct caagggcatc atcggcatcg actccgaggc cgggcccacc gagatcgcca
    18721 tcctcgccga cgacaccgcc gaccccggct acgtcgccgt cgacctgatc agccaggccg
    18781 agcacgacgt cgtcgccgcc tcggtcctgg tcaccccctc cgagcgcctc gccgccggcg
    18841 tcgaggccga actcgccgcg agggtgcccg ccaccaagca cagcgaccgc gtcgcccagg
    18901 ccctgggcgg accccagtcc ggcatcgtcc tcgtcgacga cctcgaccac ggcctggacg
    18961 tcgtcaacgc ctacgccccc gaacacctgg aggtcatgac cgccgacgcc cggtccgtcg
    19021 ccgcccgggt gcgcaacgcc ggagcgatct tcgtcgggga ccactcgccg gtgtccctgg
    19081 gcgactactg cgcgggctcc aaccacgtgc tgcccaccgg cggctgcgcc tgccactcct
    19141 ccggactgag cgtgcagagc ttcctgcgcg gcatccacgt cgtcgagtac gaccgcgccg
    19201 cactggccga ggtcgcccac cacgtggtgg ccctcgccca ggccgaagac cttcccgcgc
    19261 acggcgaggc cgtcaccgcg cgcatcccgc tggaggaaca gcagacgtga gcgacttcgg
    19321 acacaccgac ttcgggctgg aggacctgcc cctccgcgac gacctgcgcg gacagtcccc
    19381 ctacggcgcc ccgcagctga cggtgcgggc cgtcctcaac accaacgaga acccgtaccc
    19441 gccgtcgccc cggctggccg aggccatcgg ccgcgccgcc gcggaggcgg ccgccggcct
    19501 caaccgctac cccgaccgcg acgccgtcga cctgcgccgg gcgctcgccg accacctcgg
    19561 ccacggcctg gacgccgcca acgtctgggc cgccaacggc tccaacgaga tcctccagca
    19621 gatcctgcag gcgttcggcg gccccgaccg cacggccgtg ggcttcgagc cgtcctactc
    19681 catgcacccg atcatcgcgc gcggcaccgc caccgggtgg gtgtcggtgc cccgcaccgc
    19741 acgcttcgag gtggacgccg ccgacgccgt ggccgcggtc aaggagcacc agccctccgt
    19801 ggtcttcctg acctcgccca acaaccccac cggaaccgcg ctgccgctgg agaccgtcga
    19861 ggcggtcgcc gcggccgccc ccggcgtcgt cgtggtcgac gaggcctacg ccgagttccg
    19921 ccgcgagggc acccccagcg ccctgtcgct gctgcccatc caccccaacg tcatcgtctc
    19981 gcgcaccatg tccaaggcgt tcgccctggc cggggcccgc ctcggctacc tcgccgcgca
    20041 cccggccgtc gtcgacgccc tgcaactggt gcggctgccc taccacctgt cggccgtgac
    20101 gcaggcggtg gcccgcaccg ccctggagta cgccgacgaa ctgctgggcg cggtcgagac
    20161 gctgcgcgcc gaacgcgacg cgctcgtcga ctggctgcgc gcccacgact tcgaggtcgc
    20221 cgactccgac gccaacttcg tgctgttcgg ccgtcttccc gaccgctcgg aggtgttccg
    20281 gaaactgctg gaacaggggg tgctcatccg cgaggtggga ccacccgagt ggctgcgcgt
    20341 caccgtcggc accccggagg agatggcgct cttccgcgac gcgctgctca cggcgaccgg
    20401 ccgtgcctga ccacggtcct ttcccgacac acgacccgac acccggcggt tggcaccgcc
    20461 acgacgagga gaaccaccca tgagccgcat cggccgcgtc gaacgcgcca ccaacgagac
    20521 caaggtcctg gtcgagatca acctcgacgg caccggcgcc gccgacatct ccaccggcgt
    20581 cggcttctac gaccacatgc tccaccagat cgccaagcac ggactgttcg acctgaccgt
    20641 gcacaccgag ggcgacctgc acatcgactc ccaccacacg atggaggaca ccgccctcgc
    20701 cctcggcgcc gccttccggg aggccctggg cgacaagacc gggatccgcc gtttcgccga
    20761 cgtcaaggtc cccctggacg aggcgctcgc cgaggtcacc gtcgacgtct cgggccggcc
    20821 ctacctggtg cactccgagc ccgcgggcat ggcgccggtg atcggccgcg actacgacac
    20881 cacgatgacc cggcacatct tcgagtcctt cgtcgcccag gcccgcgtcg cgctgcacgt
    20941 ccacgtcccc tacggacgca acgcccacca catcgtggag tgccagttca aggcgctggc
    21001 ccgggccctg cggttcgcct gcgaacgcga cccccgcgtc agcggggtgc cctccaccaa
    21061 gggagccctg tgagcaccac ggtcctgggg gtgctgctga tcggcctcgg cggcctgctg
    21121 ttcggcggca ccctgtcgct gtggaagacc aacaaggcca tcgccgtggg cctggccgcc
    21181 tgcgcggtcc tggccctggc ggccggggtg ctgcgcctcg gctacttctg accgtcccca
    21241 caggaaggca cgtccacccg tgcagccaca cgtcgtcatc ctcgactacg gatcgggaaa
    21301 cctgcgctcc gcgcagcggg ccgtggaacg ggtcggcgcc cgcgtcaccg tcaccggcga
    21361 cccgcacacc gccctggagg ccgacgggct cgtcgtgccc ggcgtggggg cgttcgagac
    21421 ctgcatgaga gggctgcgtg ccgtccgggg cgaccgcgtc atcggcaaac gcctggcggg
    21481 aggccgtccc gtgctgggca tctgcgtcgg catgcaggtc ctgttcgacc ggggggtcga
    21541 acacggcgtc accaccgagg gctgcgggga gtggcccggc accgtggacc ggctcgacgc
    21601 ccccgtcgtc ccgcacatgg gctggaacac cgtcgacacg cccgccggat ccgagatgtt
    21661 cgccgggctc gacgaggaca cgcgcttcta cttcgtccac tcctacggcg tgcgcgcctg
    21721 ggagatggag gcgaccagcc cacacctgaa gccgccgctg gtcacctggt ccacccacgg
    21781 ctccccgttc gtggcggccg tggagaacgg tccgctgtgg gccacccagt tccacccgga
    21841 gaagtccggt gacgcggggg cccgactgct cgccaactgg atcgcgacgc tctgaacagg
    21901 ccgtcacgcg gccggacagg ccctgacgcc accctcccat ctccgtgaaa ggttcaccca
    21961 catggcgccc acactcgaac tcctgcccgc cgtcgacgtc gcgggcggcc aggcagtgca
    22021 actcgtccag ggcagggcgg acaccggcgg ccggtacggc gacccgctgg aagcggccct
    22081 ggcctggcag aacgccggag ccgagtggat ccacctggtc gacctggacg ccgccttcgg
    22141 ccggggccac aaccgggaac tgctggcctc catcgtcggt aggctcgacg tccaggtgga
    22201 actgtccggg ggaatccgcg acgacgagtc gctgaacgcg gcgctggcca cggggtgccg
    22261 ccgcgtcaac atcggcaccg ccgcactgga gaaccccgac tggtgcgcca ggatcatcgc
    22321 cgagcacggc gaccggatcg ccatcggcct ggacgtgcgc ggcaccaccc tggccgcgcg
    22381 cggctggacc cgcgagggcg gcgacctgta cgagaccctg gagcgcctgg aggccgcggg
    22441 ctgcgcccgc tacgtcgtca ccgacgtcaa caaggacggc accctcaagg gccccaacct
    22501 cg
//
