LOCUS       NZ_CP051627            21071 bp    DNA     circular CON 21-APR-2024
DEFINITION  Thermobifida alba strain DSM 43795 chromosome, complete genome.
ACCESSION   NZ_CP051627
VERSION     NZ_CP051627.1
KEYWORDS    RefSeq.
SOURCE      Thermobifida alba
  ORGANISM  Thermobifida alba
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsaceae; Thermobifida.
REFERENCE   1  (bases 1 to 4903256)
  AUTHORS   Luzics,S., Horvath,B., Nagy,I., Toth,A., Nagy,I. and Kukolya,J.
  TITLE     Thermobifida alba genome sequencing and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4903256)
  AUTHORS   Luzics,S., Horvath,B., Nagy,I., Toth,A., Nagy,I. and Kukolya,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2020) NGS Platform, Seqomics Ltd., Vallakozok u.
            7., Morahalom 6782, Hungary
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: RA v. v0.2.1; CLC Genomics Workbench v. 11.0.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 331.0x
            Sequencing Technology             :: PacBio Sequel; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023208015.1-RS_2024_04_21
            Annotation Date                   :: 04/21/2024 13:45:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,356
            CDSs (total)                      :: 4,290
            Genes (coding)                    :: 4,246
            CDSs (with protein)               :: 4,246
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 44
            CDSs (without protein)            :: 44
            Pseudo Genes (ambiguous residues) :: 0 of 44
            Pseudo Genes (frameshifted)       :: 10 of 44
            Pseudo Genes (incomplete)         :: 35 of 44
            Pseudo Genes (internal stop)      :: 3 of 44
            Pseudo Genes (multiple problems)  :: 4 of 44
            CRISPR Arrays                     :: 12
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:37:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 434790
            Orig. end                         :: 455861
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP051627.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21071
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21071
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21071
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11071](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11071
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    570..585
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.22"
                     /tool="antismash"
     misc_feature    complement(572..586)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.47"
                     /tool="antismash"
     gene            581..1183
                     /locus_tag="FOF52_RS01960"
                     /old_locus_tag="FOF52_01955"
     CDS             581..1183
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291487.1"
                     /locus_tag="FOF52_RS01960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_01955"
                     /product="sulfite oxidase-like oxidoreductase"
                     /protein_id="WP_248592114.1"
                     /transl_table=11
                     /translation="MSERRLPPGQYVPSGWPAVHYGPVPRFRPHRWDLQVYGATADAKR
                     YRWDWAGFRELPCVDVVADFHCVTRFTITDVRWRGVAASTLAELAPPAEDATHVMVWAE
                     YGYSANLRMDDFLRPDVLLATHRDGEPLAPQHGHPVRLVVPHLYGWKSVKWVRAIEYMT
                     ADRRGFWEERGYHNRADPWSEQRYSYQEDPGDGPPLD"
     gene            complement(1195..3159)
                     /gene="pknB"
                     /locus_tag="FOF52_RS01965"
                     /old_locus_tag="FOF52_01960"
     CDS             complement(1195..3159)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016188468.1"
                     /locus_tag="FOF52_RS01965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_01960"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_248593726.1"
                     /sec_met_domain="Pkinase (E-value: 2.4e-53, bitscore:
                     179.1, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAADALVGTTLAGRYRVESRIANGGMATVFVAHDLRLDRRVALK
                     VMHASLARDPQFVQRFINEALAVAKLSHPNVVQVYDQGSDQGHVYLAMEYVPGQTLRAS
                     LKARSRFSPAEALRVMVPVLAGLGAAHQAGMVHRDMKPENVLITRDGQIKVADFGLARA
                     VEASQQGLTKTGTLMGTAAYLAPEQITHSTADARSDVYACGIMLYELLTGRQPHTGDSP
                     IAVAYQHVNEDVPRPSRVVPGIPPEVDSLVVRATERDPAYRLADAGQFLAAVFATEKAL
                     QQQSAPAATAVVEAVPAAPPASAGDSDGDTQTLQAVDIPPVEYDDEDEEDGRPARPSLR
                     TPLLVVGALLLVLAVGFGWWMVDGRYETVPDLVGQESDAARHDLRLLGFRVQTAEEPAY
                     SDEAPPGTVAGTDPAAGDRLLPGTLVTLILSAGPQYVEMPDVEGASVAAARDALEEVGL
                     TDIVEDEITSYDNPPGTVITSKPAPGERADREESVTLTISAGFPVPDVVGRNVDDARSL
                     LEASDLQVEVVEEHHDEVPEGQVVAQDPEAETTVGAGQTVTLTVSSGPELVEVPDIRGW
                     KVDKARKELEELGFSVTVHQVIGDRVGDYNPKEEAPKGATIEIWTSPFGRGGDREGPGR
                     GGDRDGPGRGGDRSWFPLD"
     gene            complement(3278..4084)
                     /locus_tag="FOF52_RS01970"
                     /old_locus_tag="FOF52_01965"
     CDS             complement(3278..4084)
                     /EC_number="2.8.1.10"
                     /GO_function="GO:1990107 - thiazole synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291489.1"
                     /locus_tag="FOF52_RS01970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_01965"
                     /product="thiazole synthase"
                     /protein_id="WP_248592115.1"
                     /transl_table=11
                     /translation="MTDTLTGNPRSDTGTADDPLVIAGRSFGSRLIMGTGGAPSLRVLS
                     EALRASGTELTTVAMRRVDPNAEGSVWDVLRENAISPLPNTAGCFTAVDALRTARLGRE
                     ALETDWVKLEVVADERTLLPDPVETLDAAERLVDDGFTVLAYTNDDPVLARRLEQVGCA
                     AVMPLGAPIGSGMGIRNPHNIELIVEEARVPVILDAGIGTASDAALAMELGCDAVLLAT
                     AVTRAQDPVLMAHAMREAVTAGRRARLAGRIPVRRYAHASSPARES"
     gene            complement(4086..4286)
                     /gene="thiS"
                     /locus_tag="FOF52_RS01975"
                     /old_locus_tag="FOF52_01970"
     CDS             complement(4086..4286)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291490.1"
                     /locus_tag="FOF52_RS01975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_01970"
                     /product="sulfur carrier protein ThiS"
                     /protein_id="WP_248593727.1"
                     /transl_table=11
                     /translation="MNAIINGETRQLAPDTTVADVVRSLTRAESGVAVALNDEVVPRTD
                     WVRTVVSPDDRVDVLTAVQGG"
     misc_feature    4271..4285
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.18"
                     /tool="antismash"
     gene            complement(4289..5458)
                     /gene="thiO"
                     /locus_tag="FOF52_RS01980"
                     /old_locus_tag="FOF52_01975"
     CDS             complement(4289..5458)
                     /EC_number="1.4.3.19"
                     /GO_function="GO:0016647 - oxidoreductase activity, acting
                     on the CH-NH group of donors, oxygen as acceptor [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="thiO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291491.1"
                     /locus_tag="FOF52_RS01980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_01975"
                     /product="glycine oxidase ThiO"
                     /protein_id="WP_248592116.1"
                     /sec_met_domain="DAO (E-value: 1.9e-71, bitscore: 239.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLRSFPDVLVVGGGLIGLVTAWRAARLGMRVTVVAADESGAASG
                     VAAGMLTPATEAVFGEESLMRFGLRSLSRYPDFVADLAEDTGVDPGYRTKGTLQVAFDP
                     DDLAVLSELEKLRADLGIRTERLTSRECRRLEPMLAPSVRGGFLAPDDHSVDPRRLASA
                     LRSAAAARGVVFVPDRVVRVVVEGDSVRGVVLDRGDVVEAGQVVLAAGVWTSLIDGLPD
                     GVVPPLRPVKGQLLRLRVPTGVEPIVTRTVRGLVRGFPVYLVPRTDSEVVLGATQEEMG
                     FDTRLTVGGVWELLRDARELLPGITELAIHETCVGLRPGSPDNEPLLGPTRLRGLHLAV
                     GHFRHGVLFTPATGDVMAEALSTGRLPEYASHLAADRPLPTPSSSEGIE"
     regulatory      complement(5451..5561)
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    5482..5495
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     misc_feature    5615..5630
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 24.31"
                     /tool="antismash"
     gene            5680..6039
                     /locus_tag="FOF52_RS01985"
                     /old_locus_tag="FOF52_01980"
     CDS             5680..6039
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016188470.1"
                     /locus_tag="FOF52_RS01985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_01980"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_248592117.1"
                     /transl_table=11
                     /translation="MTPIDRDIDALVGEWLTLREAAAALNVSPNRVRQMIRDHRLLGVT
                     RAGEVSVPAAFIVDGTTPKGLRGALTLLADSGFTPEEALRWMFTADDSLPGTPIEAIRA
                     NRGTEVHRRAQAMLL"
     gene            6085..6741
                     /gene="thiE"
                     /locus_tag="FOF52_RS01990"
                     /old_locus_tag="FOF52_01985"
     CDS             6085..6741
                     /EC_number="2.5.1.3"
                     /GO_function="GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1280: thiamine-phosphate pyrophosphorylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291493.1"
                     /locus_tag="FOF52_RS01990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_01985"
                     /product="thiamine phosphate synthase"
                     /protein_id="WP_248592118.1"
                     /transl_table=11
                     /translation="MDETLRKRLEAARLYLCTDARADRGDLAEFLDAALAGGVDIVQLR
                     DKTLEAREELAALETVREACERHGALLAVNDRADIAHAVGADVLHLGQRDLPVPYARAI
                     LGDRPLIGRSTSTAELSAAADREEGVDYFCIGPAWATPTKPGRPAAGLGEVARVAALGP
                     ARPWFAIGGIDLDNLDEVLAAGARRVVVVRAITRAEDPRAAAAEFRRRLAEAAAD"
     gene            complement(6857..7774)
                     /locus_tag="FOF52_RS01995"
                     /old_locus_tag="FOF52_01990"
     CDS             complement(6857..7774)
                     /EC_number="1.6.5.2"
                     /GO_function="GO:0016655 - oxidoreductase activity, acting
                     on NAD(P)H, quinone or similar compound as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016188471.1"
                     /locus_tag="FOF52_RS01995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_01990"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_248592119.1"
                     /transl_table=11
                     /translation="MGEDLTAERIIATTGATGAVGGRVAARLARLGLAQRLVVRDLNRA
                     PELPKSSAALAAYEDPAAFGRAVRGSDVLFLVAADDAREREALHRAVVDAALAEGVRHI
                     VYLSFLNAGAAATCVLGREHHAAEAYIRSTGAAYTFLRPSLYLDLLPGWIGEDGTIRGP
                     AGDGRVAWVSRDDVADVAAAVLRAPEGHVNRVYAVTGPEAVSLGWTATRLSTLTGRTVV
                     YVPQTPEEAVDFLNSRGLSAREVAERVGACAAVAAGELDTVSTTVPRLTGHPARSLEGY
                     LRKNPSALSHAPLFGDSGKAATAP"
     misc_feature    7741..7755
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.18"
                     /tool="antismash"
     gene            7913..8419
                     /locus_tag="FOF52_RS02000"
                     /old_locus_tag="FOF52_01995"
     CDS             7913..8419
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291495.1"
                     /locus_tag="FOF52_RS02000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_01995"
                     /product="YbaK/EbsC family protein"
                     /protein_id="WP_248592120.1"
                     /transl_table=11
                     /translation="MHPNTRRVADLLAAHGASGTVRELPESARTAAAAAAQLGCEVGAI
                     ANSLVFAVRHDPDAASSDALHPVLVLTSGAHRVDTGKVAALLGAAEVVRATPQFVREHT
                     GQPIGGVAPLGHPKPIPTLVDEWLDRHEVVWAAAGHPHTVFPTSFAELCRLTGGTPADV
                     GQPHP"
     gene            8448..9062
                     /locus_tag="FOF52_RS02005"
                     /old_locus_tag="FOF52_02000"
     CDS             8448..9062
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291496.1"
                     /locus_tag="FOF52_RS02005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02000"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_248592121.1"
                     /transl_table=11
                     /translation="MGTEIELWELAAPAFVGALPALIEIYSAAMSPPPEQLPGRQAIMR
                     QHAGHPRFHSVVAVTGEGDGVAFGYGFHGRPGQWWHDVVTAELARTDPAGVRRWFADSF
                     EVAELHVLPEWQGNGIGRAVLHRLVQARRERTAVLSTHTGPTPARGLYLSSGFVDLITG
                     FRFPGTPDREFTIMAAPLPLRLPAGRSPRAAGRPRGWPSTG"
     gene            complement(8974..9915)
                     /gene="metF"
                     /locus_tag="FOF52_RS02010"
                     /old_locus_tag="FOF52_02005"
     CDS             complement(8974..9915)
                     /EC_number="1.5.1.20"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291497.1"
                     /locus_tag="FOF52_RS02010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02005"
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_248592122.1"
                     /transl_table=11
                     /translation="MLGSPTRPASRPRRISELLATGEPTFSFEFFPPKTPEGERLLWRA
                     IRELESLRPSFVSVTYGAGGGTRDRTVGVTERIATDTTLLPVAHMTAVNHSVRELRHLI
                     GRFADVGVCNILALRGDPPGDPLGEWVRHPEGLAYAEELVRLIKESGDFCVGVAAFPYK
                     HPRSPDVETDTDFFVRKCRAGADYAITQMFFEADDYLRLRDRVAARGCDVPIIPEIMPV
                     TRYATIARSEQLSGAPFPARLAEEFERVADDPEAVRALGIDHATRLCERLLAEGAPGIH
                     FITFNRSTATREVYRRLVGSARPEAAAVAARP"
     gene            10001..11071
                     /locus_tag="FOF52_RS02015"
                     /old_locus_tag="FOF52_02010"
     CDS             10001..11071
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291498.1"
                     /locus_tag="FOF52_RS02015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02010"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_248592123.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1e-45, bitscore:
                     154.0, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSSHMSPVAFVRPMIDAELAAFVTSRRPLLLEIGAELEPVLTAL
                     DAMINGGKRLRPTFCYWGWRGAGGGEEPGLYTAAAALELLQACALIHDDVIDNSDTRRG
                     LPATHRRLAALHRDSGWHGDPEQFGRGAAILLGDLCLAWCEDMYQSSALPPESLAAGRG
                     PFDRMRTEVMAGQYLDMVEQARGADTVEAALRVMRFKSAKYTVEQPLHLGAALAGRHAD
                     LASVYTAYGIPLGIAFQMRDDVLGVFGDPEETGKPAGDDLREGKRTVLVAETLRRADPA
                     DAEQFRRLLGDPGLGAEEVAWMRSVIVDSGALEACEARITDYVADATRALEDDAIADDA
                     RPALADLIVAATARKH"
     gene            complement(11497..11991)
                     /locus_tag="FOF52_RS02020"
                     /old_locus_tag="FOF52_02015"
     CDS             complement(11497..11991)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017622275.1"
                     /locus_tag="FOF52_RS02020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02015"
                     /product="transcriptional regulator"
                     /protein_id="WP_248592124.1"
                     /transl_table=11
                     /translation="MASEYAKALGARLRAIRTQQGLSLHGVEEKSHGRWKAVVVGSYER
                     GDRAVTVQKLADLADFYGVPMSELLPGGAAPAPLGPTPKLVIDLERMQQLPQDKAGPLA
                     RYVATIQSQRGDYNGRVLSIRQEDLRSLAVIYDRSPADLTEELINWGVLDPEARRAVDA
                     F"
     misc_feature    11986..11996
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     misc_feature    complement(12371..12386)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.61"
                     /tool="antismash"
     misc_feature    12380..12395
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.14"
                     /tool="antismash"
     gene            12511..13131
                     /gene="pyrR"
                     /locus_tag="FOF52_RS02025"
                     /old_locus_tag="FOF52_02020"
     CDS             12511..13131
                     /EC_number="2.4.2.9"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pyrR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291500.1"
                     /locus_tag="FOF52_RS02025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02020"
                     /product="bifunctional pyr operon transcriptional
                     regulator/uracil phosphoribosyltransferase PyrR"
                     /protein_id="WP_248592125.1"
                     /transl_table=11
                     /translation="MHARKHADGERPDQRRAVLEGPEIDRALTRIAHEILERTKGGDDL
                     TLLGIRTGGVPLAERLAQRIERVESRRVPRGALDITMYRDDLRLAPARALGRTEIPPEG
                     IDGRVVVLVDDVLFSGRTVRAALDALNDLGRPRAVQLAVLVDRGHRELPIRADYVGKNL
                     PTSLRESVTVLLEELHGRDAVLIGPAKPRPGAEPAAATPGGER"
     gene            13131..14072
                     /locus_tag="FOF52_RS02030"
                     /old_locus_tag="FOF52_02025"
     CDS             13131..14072
                     /EC_number="2.1.3.2"
                     /GO_function="GO:0004070 - aspartate carbamoyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0016597 - amino acid binding [Evidence
                     IEA]"
                     /GO_process="GO:0006207 - 'de novo' pyrimidine nucleobase
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1114: ornithine carbamoyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291501.1"
                     /locus_tag="FOF52_RS02030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02025"
                     /product="aspartate carbamoyltransferase catalytic subunit"
                     /protein_id="WP_248592126.1"
                     /transl_table=11
                     /translation="MRHLLSTGDLTRDEAVLILDTARELAQVGERSVKKLPTLRGRTVV
                     NLFYEDSTRTRISFEAAAKRMSADVINFSARGSSVSKGESLKDTALTLQAMGADGVVIR
                     HSASGAARRLAEWVDGAVVNAGDGTHEHPTQALLDAFTMRERMGHLEGLRVAIVGDIRH
                     SRVARSNVLLLHTLGAEVTLVAPPTLLPVSVGAWPCQVSYDLDEVLPKSDVVMMLRVQA
                     ERMNASFFPSAREYSRRYGLDADRFARMADHAIVMHPGPMVRGMEISAEVADSARSTVV
                     EQVTNGVSVRMAVLYLLLGGAIQGPAQQGETR"
     gene            14069..15364
                     /locus_tag="FOF52_RS02035"
                     /old_locus_tag="FOF52_02030"
     CDS             14069..15364
                     /EC_number="3.5.2.3"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017565062.1"
                     /locus_tag="FOF52_RS02035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02030"
                     /product="dihydroorotase"
                     /protein_id="WP_248592127.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 7e-14, bitscore:
                     49.7, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTKRYLIRGARVLGGEPTDLLLASGRIEAIGPGLDADGAEVVD
                     AAGAIALPGLVDLHTHLREPGREDAETVATGSRAAAMGGYTAVFAMANTDPVADTAGVV
                     EQVWRLGREAGYCDVHPVGAVTVGLRGEQLAELGAMADSPARVRVFSDDGMCVSDALLM
                     RRALEYVKAFDGVIAQHAQEPRLTEGAQMNEGVVSDRLGLAGWPAVAEEAIIARDCLLA
                     EHVGSRLHVCHVSTKGSVQIIRWAKSRGCDVTAEVTPHHLLLTDDLAESYDPVYKVNPP
                     LRTAEDVEALREGLADGTIDIVATDHAPHPSEAKETEWSQAAMGMLGLETALSVVQHTM
                     VDTGLLDWAGVAQRMSAVPARIGRVPGQGRPLAVGEPANVTLYDPAATRVVDPAAMASK
                     SRNSPYAGMRLPGRVLATFLRGKPTVLDGKIQ"
     gene            15367..16611
                     /gene="carA"
                     /locus_tag="FOF52_RS02040"
                     /old_locus_tag="FOF52_02035"
     CDS             15367..16611
                     /EC_number="6.3.5.5"
                     /GO_component="GO:0005951 - carbamoyl-phosphate synthase
                     complex [Evidence IEA]"
                     /GO_function="GO:0004088 - carbamoyl-phosphate synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0009220 - pyrimidine ribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="carA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1249: carbamoyl phosphate synthase small subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291503.1"
                     /locus_tag="FOF52_RS02040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02035"
                     /product="glutamine-hydrolyzing carbamoyl-phosphate
                     synthase small subunit"
                     /protein_id="WP_248592128.1"
                     /transl_table=11
                     /translation="MSHHARTPARPAAGPAGAPRRSDQTTTTPAEGKKNVQVPAILVLE
                     DGRVFHGVSFGAEGETFGEIVFNTGMTGYQETLTDPSYHRQIVVMTAPHVGNTGVNDDD
                     PESGRIWVAGYVVREPSRISSNWRAKRTLGEELRRQGVVGIAMPGTRALTRHLRDRGVM
                     RAAVSTVELDPAKLLERVLASPRMAGADLVEEVTTTEPYTVHPPAGVPTRFTVAAVDLG
                     IKAMTPQRLAERGCEVRVLPADTTAEQILALDPDGVFFSNGPGDPATADTAVAAMRGVL
                     DAGTPLFGICFGNQILGRALGLQTYKLPFGHRGVNQPVRDTRTGRVYITSQNHGFAVRA
                     DLDGPFDTPYGRAEVSYVGLNDNVVEGLRLLDRPAFSAQFHPEAAAGPHDAADLFDAFV
                     EMMAAHRDARESARA"
     gene            16703..20020
                     /gene="carB"
                     /locus_tag="FOF52_RS02045"
                     /old_locus_tag="FOF52_02040"
     CDS             16703..20020
                     /EC_number="6.3.5.5"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006807 - nitrogen compound metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="carB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016188473.1"
                     /locus_tag="FOF52_RS02045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FOF52_02040"
                     /product="carbamoyl-phosphate synthase large subunit"
                     /protein_id="WP_248592129.1"
                     /sec_met_domain="ATP-grasp (E-value: 4.6e-06, bitscore:
                     24.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 1.6e-06,
                     bitscore: 25.8, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRRTDLSSVLVIGSGPIVIGQACEFDYSGTQACRVLKAEGLRVI
                     LVNSNPATIMTDPEFADATYVEPITPEMVEKIIAKERPDALLPTLGGQTALNTAVALHE
                     AGVLAKYDVELIGANIDAIQAGEDRDSFKRIVERVGGESARSVICHSIEECLAAAEELN
                     YPVVVRPSFTMGGAGSGFAHDEAELRRIAGQGLALSPTTEVLLEESILGWKEYELELMR
                     DANDNVVVVCSIENLDPMGVHTGDSITVAPAMTLTDREYQRLRDLGIAVIREVGVDTGG
                     CNIQFAVHPETGRIIVIEMNPRVSRSSALASKATGFPIAKIAAKLAIGYTLDEIPNDIT
                     AETPASFEPTLDYVVVKVPRFAFEKFPGADPGLTTTMKSVGEAMAIGRCFPEALQKAMR
                     SMEKKGAAFSWAGEPGDKEELLRAVRTPSEDRLRQVQQALRAGATVDELYEATRIDRWF
                     LDQLLLLEEKARELAAAPRLDAELLRSAKRLGFSDVQIGEITGRSEELVRELRDALDVH
                     PVYLTVDTCAAEFAAKTPYLYSSYDEETEVPPSSRPKVIILGSGPNRIGQGVEFDYSCV
                     HASFALAEAGYETVMVNCNPETVSTDYDTSDRLYFEPLTLEDVLEVVRAEQATGEVAGV
                     IVQLGGQTPLGLARKLKEAGVPIVGTSPEAIDLAEDRGEFGRVLARAGLPAPKHGTAQS
                     FEEARAIAEEIGYPVLVRPSYVLGGRGMEIVYNEAMLADYIERNAEVSTDHPVLVDRFL
                     DEAVEIDVDALYDGTDLYLGGIMEHIEEAGIHSGDSACALPSITLGQEDIERIRYSTEA
                     IAAGVGVRGLLNVQYALASGVLYVLEANPRASRTVPFVSKATAVPLAKAAARVMMGATI
                     RELRAEGLLPPEGDGGTLPPEAPVAVKEAVLPFNRFIDRQGQGVDTVLGPEMRSTGEVM
                     GLDVDFGTAFAKSQLATYGALPTSGTVFVSVANRDKRTMIFPVRRLADLGFEILATEGT
                     ALALRRHGVRARVVRKHSDGPGPDGEPTIVQLIHDGEVDLIVNTPFGGPGQSGPRLDGY
                     EIRTAAVARGVPSVTTVQGLAAAVQGIESLVNGSIEVRSLQEHSRALLAATRQGTAG"
ORIGIN
        1 tcatgtggtc gccgccgatc ggcacgcccg ccacgcgcac caccgaccgc tccgcggtgt
       61 tctcccggct gaccagtttg tagggggcgg agatgtgcag cacgtcggcc acccccggca
      121 gggcgcgcag gtccagggtc gcgaaccgct ggacatcgcc cacgagcccg atgatggttc
      181 ggctcacgcc ccgggtcacg taggcctcgc cgccggccga ggcgacgagg tccacgatcg
      241 aggcgatgtt gtcggaagag gcgtcgggcg ccatcacgat gaccattgaa cgctgtcctt
      301 aacgggtgct gtggagagtg ggtgtcgggg cagcggcggg acgggaaaga caaaaaagcc
      361 ccggaccatg cggcccgggg cttcgaagtc gtccgtgtca gcgcagcgct cgtcgggcga
      421 ccgatcccgt gggccggtag ccataaaagc gccagaagtt ccgctgcatg gcagtgacta
      481 tagcgcacgg gggaggcgcc gttgccaacg aggcggagtc ggggcgtaac cgggaacctg
      541 gaaagatggc cttggatcga gcatcgggag aagagaacga ttgtctgagc gacggctgcc
      601 accagggcag tatgtgccga gcggatggcc cgcggtgcac tacggcccgg tgccgcggtt
      661 ccgcccgcac cgctgggacc tgcaggtcta cggcgccacg gcggacgcga agcggtaccg
      721 gtgggactgg gccgggttcc gggagctgcc gtgtgtcgac gtggtcgccg acttccactg
      781 tgtgaccagg ttcacgatca ccgacgtccg gtggcggggg gtggccgcgt ccaccctggc
      841 ggagctcgcc ccgccggctg aggacgcgac ccacgtcatg gtctgggccg agtacggcta
      901 cagcgccaat ctgcgcatgg acgacttcct ccgccccgac gtactgctgg ccacgcaccg
      961 tgacggcgaa ccgctggccc cccagcacgg ccatccggtg cgtctggtcg tgccgcacct
     1021 gtacggctgg aagagcgtga agtgggtgcg cgccatcgag tacatgaccg ccgaccggcg
     1081 cgggttctgg gaggagcgcg gctaccacaa ccgcgccgac ccgtggtccg agcagcgcta
     1141 ctcctaccag gaggatcccg gggacgggcc cccgctggac tgagcgggaa gcgctcagtc
     1201 cagcgggaac caggaccggt cgccgccccg gccggggccg tcccggtcac cgccccgacc
     1261 ggggccctcc cggtcgccgc cccggccgaa gggggaggtc cagatctcga tcgtggcccc
     1321 cttcggcgcc tcctccttgg ggttgtagtc gccgacccgg tcgccgatga cctggtgcac
     1381 cgtgacgctg aagcccaact cctccagctc cttgcgggcc ttgtcgacct tccagccgcg
     1441 gatgtcggga acctccacca gctccgggcc ggaggagacg gtgagcgtca cggtctgccc
     1501 ggcgcccacg gtggtctccg cctcggggtc ctgcgcgacg acctggccct cgggcacctc
     1561 gtcgtggtgc tcctcgacga cctccacctg caggtcgctg gcctccagca ggctcctggc
     1621 gtcgtccacg ttgcggccca ccacgtcggg cacggggaac ccggcgctga tggtcagcgt
     1681 cacgctctcc tcgcggtcgg cccgctcccc cggggcgggc ttggaggtga tgaccgtccc
     1741 cggcgggttg tcgtaggagg tgatctcgtc ctccacgatg tcggtcaggc ccacctcctc
     1801 cagggcgtcg cgggccgcgg ccaccgaggc gccttcgacg tcgggcatct ccacgtactg
     1861 cggccccgcc gacaggatga gggtgacgag cgtgcccggc agcagcctgt ccccggccgc
     1921 ggggtcggtt ccggcgaccg tgcccggggg agcctcgtcg ctgtaggccg gctcctcggc
     1981 ggtctgcacc ctgaagccca gcagccgcag gtcgtggcgg gccgcgtcgc tctcctggcc
     2041 gaccaggtcg ggaacggtct cgtagcggcc gtcgaccatc caccagccga acccgacggc
     2101 cagcaccagc agcagcgccc cgacgaccag cagcggggtg cgcaggctcg gccgggccgg
     2161 cctcccgtcc tcctcgtcct cgtcgtcgta ctccaccggg gggatgtcga cggcctgcag
     2221 cgtctgcgtg tcgccgtcgg agtccccggc ggaggcgggc ggcgcggcgg gcaccgcctc
     2281 caccacggcg gtggccgccg gggcggactg ctgctgcagg gccttctcgg tggcgaacac
     2341 cgcggcgagg aactggcccg cgtcggccag ccggtaggcg gggtcgcgtt cggtggcgcg
     2401 caccaccagc gagtcgacct ccgggggaat gcccggcacc acccgcgagg ggcgcggcac
     2461 gtcctcgttg acgtgctggt aggccaccgc gatcggggag tcgccggtgt gcggctgacg
     2521 gccggtgagc agctcgtaca gcatgatccc gcaggcgtag acgtcactgc gggcgtcggc
     2581 ggtgctgtgc gtgatctgct cgggagccag gtaggcggcg gtgcccatga gcgtgccggt
     2641 cttggtcagc ccctgctggc tggcctccac cgcccgggcc agcccgaagt cggccacctt
     2701 gatctgaccg tcccgggtga tcaggacgtt ctcgggcttc atgtcccggt gcaccatgcc
     2761 cgcctggtgg gcggcgccca gaccggccag caccggcacc atgacccgca gcgcctcggc
     2821 gggggagaac cgggaccgcg ccttcagcga cgcgcgcagg gtctgccccg gcacgtactc
     2881 catcgccagg tacacgtggc cctggtcgct gccctggtcg tagacctgga ccacgttggg
     2941 gtgggagagc ttggcgaccg ccagcgcctc gttgatgaac cgctggacga actgcgggtc
     3001 ccgcgccagg ctcgcgtgca tcaccttcaa cgcgacgcgt cggtccagtc gcagatcgtg
     3061 agcgacgaag acagtcgcca taccgccgtt ggcgatcctc gattcgaccc ggtaccgacc
     3121 ggcgagggtc gttcccacta gcgcgtccgc agccgtcatg tccacgaggg gcagtttacg
     3181 gtggatcgcg gaatccgacg gtgtcgagac ggtttcttcc tggtcgcgga ccggccgggc
     3241 ggggccgggg acctcccccc ggccccgccc ggccgggtca ggactcgcgg gccggggagg
     3301 aggcgtgcgc gtagcgccgg accgggatgc gtccggccag ccgcgcccgc cgcccggccg
     3361 tcaccgcctc gcgcatggcg tgcgccatca gcaccgggtc ctgcgcccgg gtgaccgcgg
     3421 tggccagcag caccgcgtcg cagcccagtt ccatggccag cgccgcgtcg ctggcggtgc
     3481 cgatgcccgc gtccaggatg acggggaccc gggcctcctc gacgatcagt tcgatgttgt
     3541 gcgggttgcg gatccccatg cccgagccga tcggcgcgcc cagcggcatc accgcggcgc
     3601 agcccacctg ctccagccgg cgggccagca cggggtcgtc gttggtgtag gcgagcacgg
     3661 tgaagccgtc gtccaccagc cgttcggcgg cgtccagcgt ctccaccggg tcggggagca
     3721 gggtgcgctc gtcggcgacc acctccagct tcacccagtc ggtctccagc gcctcgcggc
     3781 ccaggcgggc ggtgcgcagc gcgtcgacgg cggtgaagca gcccgcggtg ttgggcagcg
     3841 ggctgatggc gttctcccgc agcacgtccc agaccgaccc ctcggcgttc gggtcgaccc
     3901 ggcgcatcgc cacggtggtc aactcggtgc cggaggcgcg cagcgcctcc gacagcaccc
     3961 gcagcgacgg cgcgccgccg gtgcccatga tgagccggga accgaacgac cgcccggcga
     4021 tcaccagcgg gtcgtcggcg gtgccggtgt cggagcgggg gttcccggtc agggtgtcgg
     4081 tcaagtcagc ccccctggac ggcggtgagc acgtccaccc ggtcgtcggg ggacacgacg
     4141 gtgcgcaccc agtcggtcct gggcaccacc tcgtcgttga gcgccaccgc cacgccggac
     4201 tccgctctgg tcagggagcg caccacgtcg gcgacggtgg tgtccggagc aagctggcgc
     4261 gtctcgccgt tgatgatcgc gttcacggtc attcgatccc ttccgatgat gagggggtgg
     4321 ggagggggcg gtccgccgcg aggtggctcg cgtactcggg cagccgcccg gtgctcaggg
     4381 cctcggccat gacgtccccg gtcgccgggg tgaacagcac cccgtgccgg aagtgtccga
     4441 cggccaggtg cagtccgcgc aggcgggtgg gccccagcag gggttcgttg tcgggggagc
     4501 cggggcgcag gcccacgcag gtctcgtgga tcgccagttc ggtgatcccg ggaagcagtt
     4561 cgcgggcgtc gcgcaggagc tcccagaccc ctccgacggt cagccgggtg tcgaagccca
     4621 tctcctcctg ggtcgcgccc aggaccacct cgctgtcggt gcgcggcacc aggtacacgg
     4681 gaaagccccg gaccaggccg cgcaccgtgc gggtcacgat cggctcgacc cccgtgggga
     4741 cgcgcagccg cagcagctgt cccttgaccg ggcgcagcgg ggggaccacc ccgtcgggca
     4801 gtccgtcgat cagggaggtc cacacgcccg cggcgagcac cacctggccc gcctccacga
     4861 cgtcgccgcg gtccaggacc acgccgcgca cggagtcgcc ctcgaccacc acccggacga
     4921 cgcggtcggg cacgaacacc acgccgcgcg cggcggcggc cgaccgcagc gccgaggcga
     4981 ggcggcgcgg gtccaccgag tggtcgtcgg gggccaggaa gccgccgcgc accgaggggg
     5041 ccagcatcgg ctccaggcgg cggcactcgc gtgaggtgag ccgttcggtc cggatgccga
     5101 gatcggcccg cagcttctcc agttcggaga ggacggccag gtcgtcgggg tcgaaggcca
     5161 cctgcagggt gcccttggtg cggtaaccgg ggtccacacc ggtgtcctcg gcgaggtcgg
     5221 cgacgaagtc gggatagcgg ctgagggagc gcagcccgaa gcgcatcagc gactcctcgc
     5281 cgaacaccgc ctccgtcgcg ggggtcagca tgcctgcggc caccccggac gcggcgcccg
     5341 actcatccgc ggcgaccacg gtcacccgca tgccgaggcg ggccgcgcgc cacgcggtga
     5401 ccaggccgat cagtccaccc ccgacgacga gtacgtcggg gaacgagcgc aggtccacgg
     5461 cgctccactc ccttcgccgg tatgacccgg atcaggttct gcggtcggaa gccgccagcc
     5521 tccctctcag ccggttccgt ccggctcccg cgggtttcgc tttcgttcgc attctaggtc
     5581 gcccaggtgg tacgggggta aaggcccgat gtgtacgcct acagcgatca cggccggaga
     5641 ggggaggtgc ccgggcgccg gatgtgcgag attggaaccg tgacaccgat cgaccgcgac
     5701 atcgatgcgc tcgtgggcga gtggctcacc ctccgggaag ccgccgccgc gctcaacgtc
     5761 agccccaacc gggtcaggca gatgatccgc gaccacagac tcctgggcgt cacccgcgcg
     5821 ggagaggtct cggtcccggc cgcgttcatc gtcgacggca ccacccccaa gggcctgcgg
     5881 ggcgcgctca ccctgctggc cgacagcggc ttcaccccgg aggaggcgct gcgctggatg
     5941 ttcaccgccg acgacagcct gccgggcacc cccatcgagg cgatccgcgc caaccgcggc
     6001 accgaggtgc accgccgcgc ccaggcgatg ctgctctgag gcccggcccg gcccggcggt
     6061 ccggcggcgg ctagggtggg gggcgtggac gagaccctgc gcaagcggct tgaggccgcc
     6121 cggctgtacc tgtgcaccga cgcccgtgcc gaccgcggcg acctcgccga gttcctcgac
     6181 gcggcgctgg ccgggggcgt cgacatcgtg cagctgcgcg acaagaccct ggaggcgcgc
     6241 gaggagctcg ccgcgctgga gacggtgcgc gaggcctgcg agcgccacgg ggcgctgctg
     6301 gcggtcaacg accgcgccga catcgcccac gccgtcgggg ccgacgtgct ccacctgggc
     6361 cagcgcgacc tgcccgtgcc gtacgcccgc gcgatcctcg gcgaccgtcc gctgatcggc
     6421 cgctccacca gcacggcgga gctgtccgcg gcggccgacc gcgaggaggg cgtcgactac
     6481 ttctgcatcg gcccggcgtg ggccacgccc accaagccgg gccgtcccgc cgcgggcctc
     6541 ggcgaggtgg cgcgggtcgc cgcgctcggc cccgcccggc cctggttcgc catcggcggc
     6601 atcgacctgg acaacctcga cgaggtgctg gcggccgggg cccgccgggt cgtggtggtg
     6661 cgcgccatca cccgggccga ggacccgcgg gcggcggcgg cggagttccg gcgccgcctg
     6721 gccgaggccg cggcggactg agcgcccggg cgacgcggcc gcgcgcggcg gccggaccgg
     6781 tcggaccccg ctcccgcggc ccgcaccggc gcggggcttc gggtgccgcc tcctccgcgc
     6841 ggaggaggcc gtccggtcac ggcgccgtcg ccgctttgcc ggagtcgccg aacagcggcg
     6901 cgtgcgacag cgcgctgggg ttcttgcgca ggtagccctc cagggaccgg gccgggtggc
     6961 cggtcagcct cgggacggtc gtgctgacgg tgtccagctc cccggcggcg acggccgcgc
     7021 acgcgcccac ccgctcggcc acctcccgcg cgctcaggcc ccgggagttc aggaagtcga
     7081 ccgcctcctc gggggtctgc gggacgtaga cgacggtgcg cccggtgagc gtggacaggc
     7141 gggtggcggt ccaccccagc gacaccgcct ccgggccggt cacggcgtag acccggttca
     7201 cgtgcccctc gggggcgcgc agcacggcgg cggccacgtc ggcgacgtcg tcccgcgaca
     7261 cccaggccac ccggccgtcc ccggccgggc cgcggatcgt gccgtcctcg ccgatccacc
     7321 ccggcagcag gtccaggtac aggctgggcc gcaggaaggt gtaggccgcc ccggtggagc
     7381 ggatgtacgc ttcggcggcg tggtgctcac ggcccagcac gcacgtcgcc gcggcgcccg
     7441 cgttgaggaa cgacaggtag acgatgtggc gcacgccctc ggcgagggcc gcgtccacca
     7501 cggcgcggtg cagcgcctcc cgttcgcgcg cgtcgtcggc ggcgaccagg aacagcacgt
     7561 ccgagccccg gacggcgcgt ccgaaggcgg cggggtcctc gtaggcggcc agggccgcgc
     7621 tcgacttcgg cagttcgggg gcgcggttga ggtcacggac gaccagccgt tgcgcgagac
     7681 ccagccgtgc cagccgggcg gccactctgc cgccgacggc gccggtcgct ccggtcgtcg
     7741 cgatgatacg ttccgctgtc agatcctcac ccatgttcct tatcttcggc aaacagcccc
     7801 gcgcgtgcac tgaccggcgc gccggggttc ggcgggaggg ccgaaggcgc ggggcggccg
     7861 cgcaccggcg tccgcgggcg ggacggggcc cgacacgccc tatgatcgcg ccatgcaccc
     7921 caacacccgc agagtcgccg acctgctcgc cgcccacgga gcctccggca cggtccggga
     7981 gctgccggag tccgcacgca ccgccgcggc cgccgccgca cagctgggct gcgaggtcgg
     8041 cgcgatcgcc aacagcctcg tcttcgccgt gcgccacgac ccggacgccg cgtcctccga
     8101 cgcgctccac ccggtcctgg tcctcaccag cggcgcccac cgggtcgaca ccggcaaggt
     8161 cgccgcgctc ctcggcgcgg cggaggtggt ccgggccacc ccgcagttcg tgcgggagca
     8221 caccggccag cccatcggcg gcgtggcccc gctgggacac cccaagccga tccccaccct
     8281 cgtcgacgaa tggctggacc gccacgaggt ggtgtgggcc gcggcggggc acccgcacac
     8341 ggtgttcccc acctcgttcg cggagctgtg ccggctgacc ggcggcacac cggccgatgt
     8401 cggacaacct cacccctgag gaccggcgaa gcgcctagtg tggccgtgtg ggaaccgaaa
     8461 tcgagctgtg ggaactggcc gcaccggcct tcgtcggcgc gcttcccgcg ctgatcgaga
     8521 tctactcggc cgccatgtcc ccgccgccgg agcagttgcc ggggcggcag gccatcatgc
     8581 gccagcacgc cggacatccg cggttccact cggtggtcgc ggtgaccggg gagggggacg
     8641 gggtcgcctt cggctacggc ttccacggcc gtcccgggca gtggtggcac gacgtggtca
     8701 ccgcggaact ggcccgcacc gacccggcgg gggtgcgccg ctggttcgcc gactccttcg
     8761 aggtcgccga actccacgtg ctgccggagt ggcagggcaa cgggatcggc cgggccgtgc
     8821 tgcaccggct cgtccaggcg cggcgggagc gcacggcggt gctgtccacg cacaccgggc
     8881 ccacgcccgc ccgcgggctc tacctgtcgt ccggcttcgt ggacctgatc accggcttcc
     8941 gcttccccgg cacccccgac cgggagttca ccatcatggc cgcgccgcta ccgctgcggc
     9001 ttccggccgg gcggagccca cgagccgccg gtagacctcg cgggtggccg tcgaccggtt
     9061 gaacgtgatg aagtggatgc cgggcgcccc ctcggcgagc agccgctcgc acagccgggt
     9121 ggcgtggtcg atgccgagcg cgcgcaccgc ctcgggatcg tcggccaccc gctcgaactc
     9181 ctcggccaga cgggcgggga acggggcccc cgacagctgc tcggagcggg cgatggtggc
     9241 gtaccgggtg accggcatga tctcggggat gatcggcacg tcgcagcccc gggccgccac
     9301 ccggtcccgc agccgcaggt agtcgtcggc ctcgaagaac atctgggtga tcgcgtagtc
     9361 ggcgcccgcc cggcacttgc ggacgaagaa gtccgtgtcg gtctccacgt cgggggagcg
     9421 cgggtgcttg taggggaagg cggccacgcc cacgcagaag tcgccgctct ccttgatcag
     9481 ccgcaccagc tcctcggcgt aggccagccc ctcggggtgg cggacccact cgcccagcgg
     9541 gtcgccgggc gggtcgccgc gcagcgcgag gatgttgcac acccccacgt ccgcgaaccg
     9601 gccgatgagg tgccgcagtt cgcgcacgga gtggttgacg gccgtcatgt gcgccaccgg
     9661 cagcagcgtg gtgtcggtgg cgatccgctc ggtgacgccg accgtgcggt cgcgggtgcc
     9721 gccgcccgcg ccgtaggtca ccgacacgaa ggacgggcgc agcgactcca gctcccggat
     9781 cgcccgccag agcaggcgct ccccctcggg ggtcttggga gggaagaact cgaacgagaa
     9841 cgtgggctct ccggtcgcga gcagttcgct gatacggcgc ggtcgggacg cgggacgcgt
     9901 gggtgatccg agcatgaccc cactgtaacc gaccatatcg gtggggtttg cggcgtgtcg
     9961 tggcggagac ggacatcgga acagtcggta gcctgccctc atgacctcct cgcacatgtc
    10021 tccggtcgct ttcgtccgcc ccatgatcga cgccgagctg gcggccttcg tcacgagccg
    10081 gcgccccctg ctgctggaga tcggcgcgga gctggaaccg gtgctgaccg cgctggacgc
    10141 catgatcaac ggcggcaagc ggctgcgccc gacgttctgc tactgggggt ggcggggcgc
    10201 gggaggcggg gaggagcccg gcctgtacac ggccgccgcg gccctggagc tgctccaggc
    10261 gtgcgcgctg atccacgacg acgtgatcga caacagcgac acccggcgcg ggctgcccgc
    10321 cacccaccgc aggctggccg ccctgcaccg ggactcgggc tggcacggcg accccgagca
    10381 gttcgggcgg ggcgcggcca tcctgctggg tgacctgtgc ctggcctggt gcgaggacat
    10441 gtaccagtcg agcgcgctgc cgccggagtc gctggccgcg gggcgcggcc ccttcgaccg
    10501 gatgcgcacc gaggtcatgg ccggccagta cctggacatg gtggagcagg cgcgcggcgc
    10561 ggacaccgtg gaggcggcgc tgcgggtgat gcggttcaag tccgccaagt acaccgtcga
    10621 gcagccgctg cacctgggag cggcgctggc ggggcggcac gccgacctgg cctccgtcta
    10681 caccgcctac ggcatcccgc tgggcatcgc cttccagatg cgcgacgacg tgctcggcgt
    10741 cttcggggac ccggaggaga cgggcaagcc cgcgggggac gacctgcggg agggcaagcg
    10801 caccgtgctg gtggcggaga cgctgcgccg cgcggacccg gccgacgccg agcagttccg
    10861 gcggctgctg ggcgacccgg ggctgggcgc cgaggaggtg gcgtggatgc gttcggtcat
    10921 cgtggacagc ggggcgttgg aggcctgcga ggcccgcatc accgactacg tggccgacgc
    10981 gacccgggcc ctggaggacg acgcgatcgc cgacgacgcg cgtccggccc tggcggacct
    11041 gatcgtcgcc gccaccgccc gcaagcacta ggaggccgcg cctccggcgt cgtgcccccg
    11101 ctcggccgca ccgggggcgc gacggggccg gtgcgctgat tccgggatgt cgtcccagct
    11161 caccaaggtt gacgaacacc tgttcgaagg tgttcaatga aagtggtccg aaccgctgtc
    11221 gggggtggcg gccacgacgc cccaccggct cgttccgggg cggcggcccc tctggcgcct
    11281 cggaacgcga gtggccgggc ggggggaggg gaagcctctc gtccggccac gcccaccacc
    11341 atgggcggcc cgcccctcgg ctctgcggac cacgggtaca cacggcaccg gcggccgccc
    11401 ctcggggcgg ccgccggttc tcgtcctggt tccacgctgc tcggacccct cagcggtccg
    11461 gtgtccgagg cgcggctttg gtcgtgcgtc cggggcctag aaggcgtcga ccgcgcgccg
    11521 ggcctcgggg tcgagcacac cccagttgat gagctcctcg gtcaggtcgg cgggcgagcg
    11581 gtcgtagatg accgccagcg agcgcaggtc ctcctgcctt atggacagca cccgtccgtt
    11641 gtagtcgccg cgctggctct ggatggtcgc cacgtagcgg gcgagggggc cggccttgtc
    11701 ctggggcagc tgctgcatcc gctccaggtc gatgaccagc ttgggagtgg ggcccagcgg
    11761 cgcgggcgcg gctccgcccg gcagcagctc cgacatcggc acgccgtaga agtcggcgag
    11821 gtcggccagc ttctgcacgg tcacggcgcg gtcaccgcgc tcgtaggagc cgaccacgac
    11881 ggccttccac cgtccgtgcg acttctcctc cacgccgtgc agggacaggc cctgctgggt
    11941 acggatggcg cgcaggcggg cgcccagggc ttttgcgtat tccgatgcca tgtctctcgt
    12001 gctccccggc agtgaaaagt ggctgagacg gagggcggac ccgcggcggg ctcgttgcgg
    12061 aaccgtgtcg cgtcacaacg accggtgtgc ggctcagtcg gcgactcgcg gaatcacacc
    12121 cccacagtgg ttacggacag tgacggtagg gcggggagag tgctcaggtc aagccgttgg
    12181 gtgaaaacgc gacgattcag tggccaaact gtgtgtaagt gaggcgactc tcatactccc
    12241 cctaaacggg gcacaacgtc gcggttgatt tttcccgaat gccccctctc gtggagtttt
    12301 tcggctgctc tccccggtgt tgcccatcgt gaccacacct gctgaacctg actgctcgcg
    12361 cagagtcaag gtttgcgagt gtgatcactc tcatactttc tgcttggtgt gtccatgcta
    12421 cgtcacccgc ggaaaccggc gctggtaccg tgaaagccgt ccgacgtcct ttaacgacct
    12481 gtccagtgag gcagggaagg aggtccgctc gtgcatgccc gaaaacatgc cgacggcgag
    12541 cggccagacc agcgaagagc ggtcctggaa ggccccgaga tcgaccgcgc gctgacccgc
    12601 atcgcccacg agatcctcga acgcaccaag gggggcgacg acctcaccct cctgggcatc
    12661 cgcaccggag gcgtccccct cgccgaacgg ctcgcccagc gcatcgaacg ggtggagtcc
    12721 cgccgcgtcc cccggggcgc cctcgacatc accatgtacc gcgacgacct gcggctggcc
    12781 ccggcccgcg cgctcggccg caccgagatc ccccccgagg gcatcgacgg acgcgtcgtg
    12841 gtcctcgtcg acgacgtgct cttctccggc cgcaccgtcc gcgccgccct ggacgcgctc
    12901 aacgacctgg gccgcccccg cgcggtgcag ctggcggtcc tggtcgaccg cggccaccgc
    12961 gaactgccca tccgcgccga ctacgtcggc aagaacctgc ccacctcgct gcgggagagc
    13021 gtcaccgtcc tgctggagga gctgcacggc cgcgacgccg tcctgatcgg cccggccaag
    13081 ccccgccccg gcgccgaacc cgcggcggcc accccgggag gggagcgctg atgcggcacc
    13141 tgctctccac cggagacctc acccgcgacg aggccgtgct gatcctcgac accgcccggg
    13201 aactcgccca ggtcggcgaa cgctcggtga agaaactgcc gaccctgcgc ggacgcaccg
    13261 tggtcaacct cttctacgag gactccaccc gcacccgcat ctccttcgag gccgcggcca
    13321 agcgcatgtc ggccgacgtc atcaacttct ccgcccgcgg ctccagcgtc tccaagggcg
    13381 agagcctcaa ggacaccgca ctgaccctgc aggccatggg cgcggacggc gtggtcatcc
    13441 ggcacagcgc ctccggggcc gcgcgccgcc tcgccgaatg ggtcgacggc gcggtcgtca
    13501 acgcgggcga cggcacccac gaacacccca cgcaggccct gctggacgcc ttcaccatgc
    13561 gcgaacgcat gggacacctg gagggcctgc gtgtggccat cgtcggcgac atccggcaca
    13621 gccgcgtcgc ccgctccaac gtgctgctgc tgcacaccct gggcgccgag gtcaccctcg
    13681 tggccccgcc caccctgctg cccgtctcgg tgggcgcctg gccctgccag gtctcctacg
    13741 acctggacga ggtgctgccc aagagcgacg tcgtgatgat gctgcgggtg caggccgagc
    13801 ggatgaacgc gtccttcttc ccgtccgcgc gcgagtacag ccgccgctac ggcctggacg
    13861 ccgaccgctt cgcgcggatg gccgaccacg ccatcgtcat gcacccggga ccgatggtcc
    13921 gcggcatgga gatctccgcc gaggtcgccg actccgcccg ctccaccgtc gtggagcagg
    13981 tgaccaacgg cgtcagcgta cgcatggccg tgctgtacct gctgctgggc ggcgccatcc
    14041 agggaccggc acaacagggg gagaccagat gaccgacacc aagcgctacc tgatccgcgg
    14101 cgcccgcgtg ctgggcggcg agcccaccga cctgctgctg gcctccggcc gcatcgaggc
    14161 gatcggcccc ggcctggacg ccgacggcgc cgaggtcgtc gacgccgccg gggcgatcgc
    14221 cctgcccgga ctggtcgacc tccacaccca cctgcgcgaa cccggacggg aggacgccga
    14281 gaccgtcgcc accggttccc gcgcggccgc gatgggcggc tacaccgccg tcttcgccat
    14341 ggccaacacc gaccccgtcg ccgacaccgc cggagtcgtc gaacaggtct ggcggctggg
    14401 ccgcgaggcc ggctactgcg acgtgcaccc ggtgggcgcg gtcaccgtcg gcctgcgcgg
    14461 ggagcagctg gccgaactcg gcgcgatggc cgactccccg gcccgggtgc gggtcttctc
    14521 cgacgacggc atgtgcgtct ccgacgcgct gctcatgcgc cgcgccctgg agtacgtcaa
    14581 ggcgttcgac ggggtcatcg cccagcacgc ccaggagccg cggctgaccg agggcgccca
    14641 gatgaacgag ggcgtcgtct ccgaccggct gggactggcg ggctggcccg cggtggccga
    14701 ggaggcgatc atcgcccgcg actgcctgct cgccgagcac gtcggctcgc gcctgcacgt
    14761 ctgccacgtc tccaccaagg ggtcggtgca gatcatccgc tgggccaaga gccgcggctg
    14821 cgacgtcacc gccgaggtga ccccgcacca cctgctgctc accgacgacc tcgccgagag
    14881 ctacgacccg gtctacaagg tcaacccgcc gctgcgcacc gccgaggacg tcgaggcgct
    14941 gcgcgagggg ctcgccgacg gcacgatcga catcgtcgcc accgaccacg ccccccaccc
    15001 cagcgaggcc aaggagaccg agtggagcca ggccgcgatg ggcatgctcg gcctggagac
    15061 ggcgctgtcg gtggtgcagc acaccatggt cgacaccggc ctgctggact gggccggggt
    15121 ggcgcagcgc atgtccgccg tgcccgcccg catcggacgc gtccccggcc agggccgccc
    15181 cctcgccgtc ggggaacccg ccaacgtcac cctctacgac cccgcggcca cacgggtggt
    15241 cgaccccgcg gcgatggcct ccaagagccg caactcgccg tacgccggca tgaggctgcc
    15301 cgggcgggtg ctcgccacgt tcctgcgcgg gaagcccacc gttctcgacg ggaagatcca
    15361 gtgagcatga gccaccacgc ccggacgccc gcgcggcccg cagccggccc ggcgggcgca
    15421 ccgcgccgca gcgaccagac aaccaccacg cccgcagagg ggaagaagaa cgtgcaggtg
    15481 cccgcgatcc tggtgctgga ggacggccga gtcttccacg gggtctcctt cggagccgag
    15541 ggggagacct tcggcgagat cgtgttcaac accgggatga ccggatacca ggagaccctc
    15601 accgacccct cctaccaccg ccagatcgtg gtgatgaccg cgccgcacgt cggcaacacc
    15661 ggggtcaacg acgacgaccc cgagtcgggc cgcatctggg tggccgggta cgtcgtccgc
    15721 gagccctccc gcatctcgtc gaactggcgg gccaagcgca ccctcggcga ggagctgcgc
    15781 cgccagggcg tcgtgggcat cgcgatgccg ggcacccgag cgctcacccg ccacctgcgc
    15841 gacaggggcg tgatgcgcgc cgccgtcagc accgtggaac tcgaccccgc caaactgctg
    15901 gagcgcgtcc tggccagccc gcggatggcc ggagccgacc tggtggagga ggtcaccacc
    15961 accgagccgt acacggtcca cccgcccgcg ggggtgccca cccgcttcac cgtcgccgcg
    16021 gtcgacctcg gcatcaaggc gatgaccccg cagcggctcg ccgaacgcgg ctgcgaggtg
    16081 cgggtcctgc ccgccgacac caccgccgag cagatcctcg ccctcgaccc cgacggcgtc
    16141 ttcttcagca acggccccgg cgacccggcc accgccgaca ccgccgtggc ggcgatgcgc
    16201 ggggtgctgg acgcgggcac gccgctgttc ggcatctgct tcggcaacca gatcctgggc
    16261 cgggccctgg gactgcagac ctacaagctg cccttcggcc accgcggagt caaccagccg
    16321 gtccgcgaca cccgcaccgg acgcgtctac atcaccagcc agaaccacgg cttcgcggtc
    16381 cgcgccgacc tcgacggccc gttcgacacc ccgtacggcc gcgccgaggt cagctacgtc
    16441 ggcctcaacg acaacgtggt cgaggggctg cggctgctgg accgccccgc gttcagcgcc
    16501 cagttccacc ccgaggccgc cgccggtccg cacgacgccg ccgacctgtt cgacgccttc
    16561 gtcgagatga tggccgccca ccgggacgcg cgcgagtccg cgcgcgcctg aaccgctccg
    16621 ctccgcggac caccggcgcg cccaccgggc cacggtggcg acgccgtccg cgcctcgatc
    16681 cgacactggg gaatacacaa ccatgccgcg ccgtactgat ctttcgtctg tgctcgtgat
    16741 cggctccggg ccgatcgtca tcggccaggc gtgcgagttc gactactcgg gcacccaggc
    16801 ctgccgggtg ctcaaggccg agggcctgcg ggtcatcctg gtcaactcca acccggccac
    16861 gatcatgacc gaccccgagt tcgccgacgc cacctacgtc gagcccatca ccccggagat
    16921 ggtcgagaag atcatcgcca aggaacgccc cgacgcgctg ctgcccaccc tgggcggaca
    16981 gaccgcgctc aacaccgccg tggcgctgca cgaggccggc gtgctcgcca agtacgacgt
    17041 cgaactgatc ggcgcgaaca tcgacgccat ccaggccggc gaggaccgcg acagcttcaa
    17101 gcgcatcgtg gagcgcgtcg gcggggagtc ggcccgctcg gtgatctgcc actccatcga
    17161 ggagtgcctg gccgccgcgg aggagctgaa ctaccccgtc gtggtgcgcc cctccttcac
    17221 catgggcggc gcgggctccg gcttcgccca cgacgaggcc gaactgcgcc gcatcgccgg
    17281 gcaggggctg gcgctctcgc ccaccaccga ggtgctcctg gaggagtcca tcctcggctg
    17341 gaaggagtac gagctggagc tgatgcgcga cgccaacgac aacgtggtcg tcgtctgctc
    17401 catcgagaac ctcgacccga tgggcgtgca caccggcgac tccatcacgg tggcgcccgc
    17461 catgaccctc accgaccgcg agtaccagcg gctgcgcgac ctcggcatcg ccgtcatccg
    17521 cgaggtgggc gtcgacaccg gcggctgcaa catccagttc gcggtgcacc ccgagaccgg
    17581 ccggatcatc gtcatcgaga tgaacccgcg cgtctcgcgg tcctcggcgc tggcctccaa
    17641 ggccaccggc ttccccatcg ccaagatcgc cgccaagctc gccatcggct acaccctgga
    17701 cgagatcccc aacgacatca ccgccgagac cccggccagc ttcgagccga ccctggacta
    17761 cgtcgtcgtc aaggtgccgc ggttcgcgtt cgagaagttc cccggcgccg accccggcct
    17821 gaccaccacc atgaagtcgg tgggcgaggc gatggccatc ggccgctgct tccccgaggc
    17881 gctgcagaag gccatgcgct cgatggagaa gaagggcgcc gccttcagct gggcgggcga
    17941 gcccggcgac aaggaggagc tgctgcgcgc ggtgcgcacg cccagcgagg accggctgcg
    18001 ccaggtccag caggccctgc gcgcgggggc caccgtcgac gaactgtacg aggccacccg
    18061 gatcgaccgg tggttcctgg accagctgct gctgctggag gagaaggccc gcgagctggc
    18121 cgcggccccc cggctggacg ccgaactgct gcgctcggcc aagcggctgg gcttctccga
    18181 tgtccagatc ggcgagatca ccggccgctc cgaggagctc gtgcgggagc tgcgcgacgc
    18241 cctggacgtg cacccggtct acctgaccgt ggacacctgc gccgcggagt tcgccgcgaa
    18301 gacgccctac ctgtactcca gctacgacga ggagaccgag gtcccgccca gcagccggcc
    18361 caaggtcatc atcctcggct ccggccccaa ccgcatcggg cagggcgtgg agttcgacta
    18421 cagctgcgtg cacgcgtcct tcgcgctggc cgaggccgga tacgagaccg tcatggtcaa
    18481 ctgcaacccc gagacggtct ccaccgacta cgacaccagc gaccggctgt acttcgagcc
    18541 gctgacgctg gaggacgtgc tggaggtggt gcgcgccgag caggccaccg gcgaggtcgc
    18601 gggcgtgatc gtgcagctgg gcggccagac cccgctgggc ctggccagga agctcaagga
    18661 ggccggggtg ccgatcgtgg gcaccagccc cgaggccatc gacctggccg aggaccgcgg
    18721 cgagttcggc cgggtcctgg ccagggccgg actgcccgcc cccaagcacg gcaccgccca
    18781 gtccttcgag gaggcccggg ccatcgccga ggagatcggc tacccggtgc tggtgcgccc
    18841 ctcctacgtg ctgggcggcc gcggcatgga gatcgtctac aacgaggcca tgctcgccga
    18901 ctacatcgag cgcaacgccg aggtcagcac cgaccacccg gtcctggtgg accgcttcct
    18961 cgacgaggcc gtcgagatcg acgtggacgc cctctacgac gggaccgacc tgtacctggg
    19021 cggcatcatg gagcacatcg aggaggcggg catccactcc ggcgactccg catgcgccct
    19081 gccgtccatc acgctcggcc aggaggacat cgagcgcatc cgctactcca ccgaggccat
    19141 cgccgcgggg gtcggggtgc gcggcctgct caacgtgcag tacgcgctgg cctccggggt
    19201 gctctacgtg ctggaggcca acccgcgggc ctcgcgcacc gtgccgttcg tctccaaggc
    19261 caccgcggtg ccgctggcca aggccgccgc ccgggtgatg atgggcgcca ccatccgcga
    19321 gctgcgcgcc gaggggctgc tgccgccgga gggcgacggc ggcacgctgc cgccggaggc
    19381 gccggtcgcg gtcaaggagg cggtgctgcc cttcaaccgc ttcatcgacc gccagggcca
    19441 gggcgtggac accgtgctgg gcccggagat gcgctccacc ggcgaggtca tgggcctgga
    19501 cgtggacttc ggcaccgcct tcgccaagtc ccagctggcc acctacgggg cgctgcccac
    19561 ctccgggacg gtgttcgtct ccgtggccaa ccgcgacaag cgcaccatga tcttcccggt
    19621 caggcgcctg gcggacctgg gcttcgagat cctggccacc gagggcaccg ccctggcgct
    19681 gcgccgccac ggcgtccggg cccgcgtggt gcgcaagcac agcgacggcc ccggccccga
    19741 cggcgagccg acgatcgtgc agctcatcca cgacggcgag gtggacctca tcgtcaacac
    19801 cccgttcggc gggcccggcc agtccgggcc ccggctggac ggctacgaga tccgcaccgc
    19861 cgcggtggcc cgcggggtgc ccagcgtcac caccgtccag gggctggccg ccgccgtcca
    19921 gggcatcgag tccctggtca acggcagtat cgaggtgcgc tccctgcagg agcactcccg
    19981 cgcgctgctg gccgccacac ggcagggcac ggcggggtga gccccggtcc ggggacggtc
    20041 cgcgcggacc gtccccggac cgcgtccggt tgcggaacaa tggtgcagcg agcgtccggg
    20101 gagcggagtt cctcttcgcg ggcccctcgc ggcccgtcgc acgaggcccg gcaggcgctc
    20161 gaagcggtgg cggagaccgg aggggaccct ctcagtgagt gacgtgcggc cggtgcagat
    20221 gagcagcccg gtactgacgg tgcggcaggt ggacgcctac cacgccatca cggtggtcgc
    20281 tccgggcatc gcggagcggt tccgctcggg gcagttcatc gccgtggccg tcggcggcga
    20341 gcactccgcc atgctcaccc ggcgggtgtt cgccatccac gaggtcaagc ccgactacgg
    20401 cggaaccgtg gagttcctgt tcgcggtgcg cggcaggggc accgcctggc tggccgagcg
    20461 gcgctcccgg gacctgctgg acgtcatcgg cccgctgggg cggccgttcc cgctgccgcg
    20521 ggacccggtc aactgcgtcc tggtcggcgg cggctccggc agcgccccgc tgttcccgct
    20581 ggcgcacgcg ctgcggcggc ggggctgccg ggtggacttc gtgctgggcg gggccacggc
    20641 gtcgcgggtg ttcagcgcgc tcaccgcgcg gcggatcgcc gagagcgcga ccttcaccac
    20701 cgacgacggc tcgctcggca cgaggggccg ggtcaccgac gtcctcgccc gggtgatcga
    20761 cgaggcctgc tcggacgtgg tgtacgcgtg cgggccgatg ccgatgctgc gcgaggtcac
    20821 cgcgatggcg atgcgctacg gcatcccggt ccaggtctcg gtggaggaga ccatggcctg
    20881 cggcacgggg atctgcatgt cgtgcgtggt cccggtggtg ggggaggacg gcatcacccg
    20941 catggcgcgc gcctgcgtgg acgggccggt gttccggggg gagcgggtgc ggttcgacga
    21001 cgtcggaacg gtccccttcg acgccctggg cgccccggga tggaaggcgc ggggagggga
    21061 ggaccgggcc c
//
