GCF_023162015.2 - 5 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP116958.1 (Streptococcus pasteurianus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	RiPP-like	89,362	100,588
Region 2	terpene-precursor	555,402	576,271
Region 3	T3PKS	1,310,107	1,351,285
Region 4	lanthipeptide-class-i	1,501,088	1,528,343	High	suicin 90-1330	ribosomal:RiPP
Region 5	RiPP-like	2,180,100	2,194,007

NZ_CP116958.1 - Region 1 - RiPP-like

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Location: 89,362 - 100,588 nt. (total: 11,227 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acetyltransferase

M0P28_RS00725: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Similar gene clusters

Analysis type:

Reference	RiPP-like	Similarity score	Type	Compound(s)	Organism
BGC0000628.4		0.29	ribosomal	lactocillin	Lactobacillus paragasseri JV-V03
BGC0002468.2		0.21	NRPS	anguibactin	Vibrio anguillarum 775

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0000628.4		0.29	ribosomal	lactocillin	Lactobacillus paragasseri JV-V03
BGC0002468.2		0.21	NRPS	anguibactin	Vibrio anguillarum 775

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

Additional weak hits (5):

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 20.83 out of 32.38

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.55 out of 32.93

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.69 out of 27.55

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 19.72 out of 32.38

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ToxT	Regulator of MSHA biosynthesis

NZ_CP116958.1 - Region 2 - terpene-precursor

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Location: 555,402 - 576,271 nt. (total: 20,870 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carbamoyltransferase

M0P28_RS03075: ornithine carbamoyltransferase

smcogs: SMCOG1114: ornithine carbamoyltransferase

Ligases: synthetase

M0P28_RS03130: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002635.2	0.38	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0000542.3	0.37	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.37	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000555.3	0.37	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0001407.5	0.37	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000488.4	0.37	ribosomal	circularin A	Clostridium beijerinckii
BGC0000552.3	0.36	ribosomal	SmbA, SmbB	Streptococcus mutans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002635.2	0.38	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0000542.3	0.37	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.37	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000555.3	0.37	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0001407.5	0.37	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000488.4	0.37	ribosomal	circularin A	Clostridium beijerinckii
BGC0000552.3	0.36	ribosomal	SmbA, SmbB	Streptococcus mutans

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

M0P28_RS03130: PT_FPPS_like

Domain 1 (25 - 273): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.38 out of 25.88

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.06 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.35 out of 26.06

Confidence: medium

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.86 out of 26.12

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.74 out of 27.78

Confidence: strong

Additional weak hits (4):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.05 out of 32.74

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.25 out of 30.98

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.54 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.47 out of 28.14

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LuxO	Repressor of luminescence
MogR	Repressor of flagellar motility genes
PsrA	Oleic acid responsive regulator
ToxT	Regulator of MSHA biosynthesis

NZ_CP116958.1 - Region 3 - T3PKS

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Location: 1,310,107 - 1,351,285 nt. (total: 41,179 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase reductase

M0P28_RS06840: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

M0P28_RS06905: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Ligases: synthase

M0P28_RS06835: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002561.3	0.45	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0002707.2	0.41	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0000513.3	0.41	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000515.4	0.41	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000286.3	0.40	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0001210.5	0.40	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000501.3	0.40	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0002260.3	0.40	terpene	trichobrasilenol, xylarenic acid B, brasilane A, brasilane F, brasilane E, brasilane D	Annulohypoxylon truncatum
BGC0002699.2	0.40	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0000205.3	0.40	PKS	bryostatin	Candidatus Endobugula sertula

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002561.3	0.45	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0002707.2	0.41	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0000513.3	0.41	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000515.4	0.41	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000286.3	0.40	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0001210.5	0.40	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000501.3	0.40	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0002260.3	0.40	terpene	trichobrasilenol, xylarenic acid B, brasilane A, brasilane F, brasilane E, brasilane D	Annulohypoxylon truncatum
BGC0002699.2	0.40	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0000205.3	0.40	PKS	bryostatin	Candidatus Endobugula sertula

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.80 out of 27.55

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.69 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.78 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.73 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.19 out of 26.06

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.93 out of 30.25

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 22.47 out of 25.31

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05

Confidence: medium

Additional weak hits (4):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 23.43 out of 30.22

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.88 out of 27.55

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 24.19 out of 30.22

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.57 out of 29.72

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CatR	H2O2-responsive repressor
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
GnfM	Regulator of nitrogen-fixation genes
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_CP116958.1 - Region 4 - lanthipeptide-class-i

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Location: 1,501,088 - 1,528,343 nt. (total: 27,256 nt) Show pHMM detection rules used

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

M0P28_RS07785: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase dehydratase

M0P28_RS07730: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

M0P28_RS07740: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

M0P28_RS07750: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001789.3	0.96	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000537.3	0.85	ribosomal	nisin U	Streptococcus uberis
BGC0000535.4	0.73	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0000536.3	0.73	ribosomal	nisin Q	Lactococcus lactis
BGC0000538.3	0.73	ribosomal	nisin Z	Lactococcus lactis
BGC0002640.2	0.56	ribosomal	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0000506.4	0.56	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000556.5	0.56	ribosomal	streptin	Streptococcus pyogenes
BGC0000549.3	0.55	ribosomal	salivaricin D	Streptococcus salivarius
BGC0000559.4	0.54	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001789.3	0.96	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000537.3	0.85	ribosomal	nisin U	Streptococcus uberis
BGC0000535.4	0.73	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0000536.3	0.73	ribosomal	nisin Q	Lactococcus lactis
BGC0000538.3	0.73	ribosomal	nisin Z	Lactococcus lactis
BGC0002640.2	0.56	ribosomal	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0000506.4	0.56	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000556.5	0.56	ribosomal	streptin	Streptococcus pyogenes
BGC0000549.3	0.55	ribosomal	salivaricin D	Streptococcus salivarius
BGC0000559.4	0.54	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for M0P28_RS07740

M0P28_RS07755

Leader:

MNNEDFNLDLVTISKENNSGASPR

Core:

VTSKSLCTPGCKTGILMTCAIKTATCGCHFG

Core with dehydrations:

VDhbDhaKDhaLCysDhbPGCysKDhbGILMDhbCysAIKDhbADhbCysGCysHFG

antiSMASH-DB 4.0 matches for M0P28_RS07755

100.0%

NC_015600.1and 14 others:

NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptideNZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptideNZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptideNZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptideNZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptideNZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptideNZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptideNZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptideNZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptideNZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptideNZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptideNZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptideNZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide

Lanthipeptides: SGPB_RS10680_lanthipeptide

VTSKSLCTPGCKTGILMTCAIKTATCGCHFG

96.9%

NZ_JAMDIB010000004.1:

Lanthipeptides: M5P35_RS04030_lanthipeptide

VTSKSLCTP-GCKTGILMTCAIKTATCGCHFG

VTSKSLCTP GCKTGILMTCAIKTATCGCHFG

VTSKSLCTPPGCKTGILMTCAIKTATCGCHFG

93.5%

NZ_CP024974.1and 1 other:

NZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptide

Lanthipeptides: CVO91_RS06555_lanthipeptide

VTSKSLCTPGCKTGILMTCAIKTATCGCHF

VTS SLCTPGCKTGILMTCAIKTATCGCHF

VTSISLCTPGCKTGILMTCAIKTATCGCHF

with 99 more sequence matches

Only the first 10 are displayed here.

87.5%

NZ_CP059471.1and 3 others:

NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptideNZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptideNZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide

Lanthipeptides: H1R75_RS06635_lanthipeptide

VTSKSLCTPGCKTGILMTCAIKTATCGCHFG

+TSKSLCTPGCKTG LMTC IKTATCGCHFG

ITSKSLCTPGCKTGALMTCPIKTATCGCHFG

77.8%

NZ_NHVL01000013.1and 1 other:

NZ_NHVL01000013.1 Lanthipeptides: CEU70_RS16830_lanthipeptide

Lanthipeptides: CEU70_RS16825_lanthipeptide

VTSKSLCTPGCKTGILMTCAIKTATCGC--HFG

VTSKSLCTPGCKTGIL TCAIK+ATCGC H G

VTSKSLCTPGCKTGILQTCAIKSATCGCSIHIG

69.7%

NZ_CP015405.2and 7 others:

NZ_CP015405.2 Lanthipeptides: A4V09_RS08295_lanthipeptideNZ_CP015405.2 Lanthipeptides: A4V09_RS08290_lanthipeptideNZ_CP015405.2 Lanthipeptides: A4V09_RS08285_lanthipeptideNZ_CP053228.1 Lanthipeptides: HL650_RS06240_lanthipeptideNZ_CP053228.1 Lanthipeptides: HL650_RS06235_lanthipeptideNZ_CP053228.1 Lanthipeptides: HL650_RS06230_lanthipeptideNZ_CP053228.1 Lanthipeptides: HL650_RS06225_lanthipeptide

Lanthipeptides: A4V09_RS08300_lanthipeptide

VTSKSLCTPGCKTGILMTCAIKTATCGCHF

+TSKSLCTPGC TGILMTC ++TATCGC

ITSKSLCTPGCVTGILMTCPVQTATCGCQI

69.7%

NZ_JADNJR010000016.1and 2 others:

NZ_JADNJR010000016.1 Lanthipeptides: I2E58_RS10875_lanthipeptideNZ_QSHK01000002.1 Lanthipeptides: DW860_RS04740_lanthipeptide

Lanthipeptides: I2E58_RS10880_lanthipeptide

SKSLCTPGCKTGILMTCAIKTATCGCHF

SKS CTPGC TGILMTC +KTATCGCH

SKSACTPGCPTGILMTCPLKTATCGCHI

69.7%

NZ_QSHK01000002.1and 1 other:

NZ_QSHK01000002.1 Lanthipeptides: DW860_RS04730_lanthipeptide

Lanthipeptides: DW860_RS04735_lanthipeptide

SKSLCTPGCKTGILMTCAIKTATCGCHF

SKS+CTPGC TGILMTC +KTATCGCH

SKSVCTPGCPTGILMTCPLKTATCGCHI

66.7%

NZ_FNDP01000013.1and 1 other:

NZ_FNDP01000013.1 Lanthipeptides: BLP54_RS11220_lanthipeptide

Lanthipeptides: BLP54_RS11225_lanthipeptide

VTSKSLCTPGCKTGILMTCAIKTATCGC--HFG

+TSKSLCTPGC TG+LM CA +ATC C H G

ITSKSLCTPGCVTGLLMGCAGSSATCNCSVHVG

65.7%

NZ_FNDP01000013.1:

Lanthipeptides: BLP54_RS11230_lanthipeptide

VTSKSLCTPGCKTGILMTCAIKTATCGC--HFG

+TSKSLCTPGC TG+LM C KTATC C H G

ITSKSLCTPGCVTGVLMGCNNKTATCNCSVHVG

64.7%

NZ_CP090412.1and 3 others:

NZ_QSTB01000004.1 Lanthipeptides: DXC22_RS03785_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide

Lanthipeptides: LZF92_RS09890_lanthipeptide

VTSKSLCTPGCKTGILMTCAIKTATCGCHF

+TS SLCTPGCKTG LM C +KTA+CGCH

ITSYSLCTPGCKTGALMGCTMKTASCGCHV

64.7%

NZ_FBTD01000003.1:

Lanthipeptides: PB1E_RS03075_lanthipeptide

VTSKSLCTPGCKTGILMTCAIKTATCGCHF

+TS SLCTPGCKTG LM C +KTA+CGCH

ITSVSLCTPGCKTGALMGCNMKTASCGCHV

62.9%

NZ_CP013655.1and 2 others:

NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptideNZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide

Lanthipeptides: ATZ35_RS03640_lanthipeptide

VTSKSLCTPGCKTGILMTCAIKTATCGCHFG

+TSKSLCTPGC TG+LM CA+KT TC C G

ITSKSLCTPGCVTGVLMGCALKTITCNCSVG

MIBiG 4.0 matches for M0P28_RS07755

61.8%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

VTSKSLCTPGCKTGILMTCAIKTATCGC

+TS SLCTPGCKTG LM C +KTATC C

ITSISLCTPGCKTGALMGCNMKTATCHC

Lanthipeptide(s) for M0P28_RS07750

M0P28_RS07755

Leader:

MNNEDFNLDLVTISKENNSGASPR

Core:

VTSKSLCTPGCKTGILMTCAIKTATCGCHFG

Core with dehydrations:

VDhbDhaKDhaLCysDhbPGCysKDhbGILMDhbCysAIKDhbADhbCysGCysHFG

antiSMASH-DB 4.0 matches for M0P28_RS07755

100.0%

NC_015600.1and 14 others:

Lanthipeptides: SGPB_RS10680_lanthipeptide

VTSKSLCTPGCKTGILMTCAIKTATCGCHFG

96.9%

NZ_JAMDIB010000004.1:

Lanthipeptides: M5P35_RS04030_lanthipeptide

VTSKSLCTP-GCKTGILMTCAIKTATCGCHFG

VTSKSLCTP GCKTGILMTCAIKTATCGCHFG

VTSKSLCTPPGCKTGILMTCAIKTATCGCHFG

93.5%

NZ_CP024974.1and 1 other:

NZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptide

Lanthipeptides: CVO91_RS06555_lanthipeptide

VTSKSLCTPGCKTGILMTCAIKTATCGCHF

VTS SLCTPGCKTGILMTCAIKTATCGCHF

VTSISLCTPGCKTGILMTCAIKTATCGCHF

with 99 more sequence matches

Only the first 10 are displayed here.

87.5%

NZ_CP059471.1and 3 others:

NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptideNZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptideNZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide

Lanthipeptides: H1R75_RS06635_lanthipeptide

VTSKSLCTPGCKTGILMTCAIKTATCGCHFG

+TSKSLCTPGCKTG LMTC IKTATCGCHFG

ITSKSLCTPGCKTGALMTCPIKTATCGCHFG

77.8%

NZ_NHVL01000013.1and 1 other:

NZ_NHVL01000013.1 Lanthipeptides: CEU70_RS16830_lanthipeptide

Lanthipeptides: CEU70_RS16825_lanthipeptide

VTSKSLCTPGCKTGILMTCAIKTATCGC--HFG

VTSKSLCTPGCKTGIL TCAIK+ATCGC H G

VTSKSLCTPGCKTGILQTCAIKSATCGCSIHIG

69.7%

NZ_CP015405.2and 7 others:

Lanthipeptides: A4V09_RS08300_lanthipeptide

VTSKSLCTPGCKTGILMTCAIKTATCGCHF

+TSKSLCTPGC TGILMTC ++TATCGC

ITSKSLCTPGCVTGILMTCPVQTATCGCQI

69.7%

NZ_JADNJR010000016.1and 2 others:

NZ_JADNJR010000016.1 Lanthipeptides: I2E58_RS10875_lanthipeptideNZ_QSHK01000002.1 Lanthipeptides: DW860_RS04740_lanthipeptide

Lanthipeptides: I2E58_RS10880_lanthipeptide

SKSLCTPGCKTGILMTCAIKTATCGCHF

SKS CTPGC TGILMTC +KTATCGCH

SKSACTPGCPTGILMTCPLKTATCGCHI

69.7%

NZ_QSHK01000002.1and 1 other:

NZ_QSHK01000002.1 Lanthipeptides: DW860_RS04730_lanthipeptide

Lanthipeptides: DW860_RS04735_lanthipeptide

SKSLCTPGCKTGILMTCAIKTATCGCHF

SKS+CTPGC TGILMTC +KTATCGCH

SKSVCTPGCPTGILMTCPLKTATCGCHI

66.7%

NZ_FNDP01000013.1and 1 other:

NZ_FNDP01000013.1 Lanthipeptides: BLP54_RS11220_lanthipeptide

Lanthipeptides: BLP54_RS11225_lanthipeptide

VTSKSLCTPGCKTGILMTCAIKTATCGC--HFG

+TSKSLCTPGC TG+LM CA +ATC C H G

ITSKSLCTPGCVTGLLMGCAGSSATCNCSVHVG

65.7%

NZ_FNDP01000013.1:

Lanthipeptides: BLP54_RS11230_lanthipeptide

VTSKSLCTPGCKTGILMTCAIKTATCGC--HFG

+TSKSLCTPGC TG+LM C KTATC C H G

ITSKSLCTPGCVTGVLMGCNNKTATCNCSVHVG

64.7%

NZ_CP090412.1and 3 others:

NZ_QSTB01000004.1 Lanthipeptides: DXC22_RS03785_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide

Lanthipeptides: LZF92_RS09890_lanthipeptide

VTSKSLCTPGCKTGILMTCAIKTATCGCHF

+TS SLCTPGCKTG LM C +KTA+CGCH

ITSYSLCTPGCKTGALMGCTMKTASCGCHV

64.7%

NZ_FBTD01000003.1:

Lanthipeptides: PB1E_RS03075_lanthipeptide

VTSKSLCTPGCKTGILMTCAIKTATCGCHF

+TS SLCTPGCKTG LM C +KTA+CGCH

ITSVSLCTPGCKTGALMGCNMKTASCGCHV

62.9%

NZ_CP013655.1and 2 others:

NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptideNZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide

Lanthipeptides: ATZ35_RS03640_lanthipeptide

VTSKSLCTPGCKTGILMTCAIKTATCGCHFG

+TSKSLCTPGC TG+LM CA+KT TC C G

ITSKSLCTPGCVTGVLMGCALKTITCNCSVG

MIBiG 4.0 matches for M0P28_RS07755

61.8%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

VTSKSLCTPGCKTGILMTCAIKTATCGC

+TS SLCTPGCKTG LM C +KTATC C

ITSISLCTPGCKTGALMGCNMKTATCHC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.03 out of 32.74

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 19.31 out of 27.18

Confidence: weak

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

M0P28_RS07755 - Class I

Cleavage pHMM score: 27.40

RODEO score: 28

Monoisotopic mass: 2987.5 Da

Molecular weight: 2989.6 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3007.6 Da N = 1; 3025.7 Da N = 2; 3043.7 Da N = 3

M0P28_RS07755 - Class I

Cleavage pHMM score: 27.40

RODEO score: 28

Monoisotopic mass: 2987.5 Da

Molecular weight: 2989.6 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3007.6 Da N = 1; 3025.7 Da N = 2; 3043.7 Da N = 3

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 144 - 226; Score: 26.6

TFBS definitions

Regulator	Description

NZ_CP116958.1 - Region 5 - RiPP-like

Download region GenBank file

Download region SVG

Location: 2,180,100 - 2,194,007 nt. (total: 13,908 nt) Show pHMM detection rules used

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000617.5	0.54	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.50	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002577.2	0.44	ribosomal	lactococcin G	Lactococcus lactis
BGC0000619.3	0.44	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.44	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.44	ribosomal	gassericin E	Lactobacillus gasseri
BGC0002580.2	0.43	ribosomal	lactococcin MN	Lactococcus cremoris
BGC0002674.2	0.42	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000624.3	0.41	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0001862.4	0.40	ribosomal	pallidocin	Aeribacillus pallidus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000617.5	0.54	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.50	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002577.2	0.44	ribosomal	lactococcin G	Lactococcus lactis
BGC0000619.3	0.44	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.44	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.44	ribosomal	gassericin E	Lactobacillus gasseri
BGC0002580.2	0.43	ribosomal	lactococcin MN	Lactococcus cremoris
BGC0002674.2	0.42	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000624.3	0.41	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0001862.4	0.40	ribosomal	pallidocin	Aeribacillus pallidus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.46 out of 30.25

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.46 out of 30.25

Confidence: medium

Additional weak hits (1):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.69 out of 29.38

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ColR	Phenol-responsive regulator