LOCUS       NZ_CP116958            27256 bp    DNA     circular CON 27-MAR-2024
DEFINITION  Streptococcus pasteurianus strain WUSP074 chromosome, complete
            genome.
ACCESSION   NZ_CP116958
VERSION     NZ_CP116958.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pasteurianus
  ORGANISM  Streptococcus pasteurianus
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2371672)
  AUTHORS   Wang,S. and Wu,Z.
  TITLE     The identification of Streptococcus pasteurianus by multiplex PCR
            assay and the characteristics of pathogenicity and antimi-crobial
            resistance of this zoonotic pathogen
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2371672)
  AUTHORS   Wang,S. and Wu,Z.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-JAN-2023) College of Veterinary Medicine, Nangjing
            Agricultural University, Weigang No. 1, Nanjing, Jiangsu 210095,
            China
REFERENCE   3  (bases 1 to 2371672)
  AUTHORS   Wang,S. and Wu,Z.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2022) College of Veterinary Medicine, Nangjing
            Agricultural University, Weigang No. 1, Nanjing 210095, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.15
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 500.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023162015.2-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 06:55:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,411
            CDSs (total)                      :: 2,319
            Genes (coding)                    :: 2,195
            CDSs (with protein)               :: 2,195
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 124
            CDSs (without protein)            :: 124
            Pseudo Genes (ambiguous residues) :: 0 of 124
            Pseudo Genes (frameshifted)       :: 56 of 124
            Pseudo Genes (incomplete)         :: 84 of 124
            Pseudo Genes (internal stop)      :: 36 of 124
            Pseudo Genes (multiple problems)  :: 40 of 124
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:54:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1501087
            Orig. end                         :: 1528343
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP116958.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..27256
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="4"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..27256
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27256
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:17256](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..17256)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(<505..951)
                     /locus_tag="M0P28_RS12080"
                     /pseudo=""
     CDS             complement(<505..951)
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019149.4"
                     /locus_tag="M0P28_RS12080"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="recombinase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNSMKRSGKNMSWLPPFGYLKDPGDRFKIIIDETVAPIVRRIFAL
                     YLDGNSYQTIARLLN"
     gene            complement(1126..1401)
                     /locus_tag="M0P28_RS07665"
                     /old_locus_tag="M0P28_07665"
     CDS             complement(1126..1401)
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012464.4"
                     /locus_tag="M0P28_RS07665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07665"
                     /product="recombinase family protein"
                     /protein_id="WP_240208137.1"
                     /transl_table=11
                     /translation="MSKVALYLRLSVDEADKDESNSITNQRYLLNHYLDQTPEFKNWER
                     LEFVDDGFSGTSLNRPSFQRLMAAVKVGTIRHILVKDLSRFMRDYL"
     misc_feature    1604..1622
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 24.03"
                     /tool="antismash"
     gene            complement(1822..2914)
                     /locus_tag="M0P28_RS07670"
                     /old_locus_tag="M0P28_07670"
                     /pseudo=""
     CDS             complement(1822..2914)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1164: transposase
                     IS3/IS911 family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611996.1"
                     /locus_tag="M0P28_RS07670"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07670"
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSRKIRRHFTDDFKQQIVDLHNAGMKRSELIKEYELTPSTFDKWV
                     RQAKLTGSFKSVDNMTDEQRELIQLKKRNKELEMQLDILKQAAVIMARKDK"
     gene            complement(<2984..3154)
                     /locus_tag="M0P28_RS07675"
                     /old_locus_tag="M0P28_07675"
                     /pseudo=""
     CDS             complement(<2984..3154)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019213953.1"
                     /locus_tag="M0P28_RS07675"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07675"
                     /product="MobA/MobL family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MADSFHFSVNIISRGKGKSAVASAAYISGEKIKNEWDGVTHDYTR
                     KEKVLVKNIILP"
     gene            complement(3572..3868)
                     /locus_tag="M0P28_RS07680"
                     /old_locus_tag="M0P28_07680"
                     /pseudo=""
     CDS             complement(3572..3868)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002846351.1"
                     /locus_tag="M0P28_RS07680"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07680"
                     /product="DUF3847 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKNIDEKILMAEEEIKQLQNKRKKLISKQKQEERKKRDRRLYEKG
                     GVF"
     gene            complement(3976..4542)
                     /locus_tag="M0P28_RS07685"
                     /old_locus_tag="M0P28_07685"
     CDS             complement(3976..4542)
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005602880.1"
                     /locus_tag="M0P28_RS07685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07685"
                     /product="GNAT family protein"
                     /protein_id="WP_117479700.1"
                     /transl_table=11
                     /translation="MSNIYKNVPKFESEKFLLRFVDKDDVEDLFAVYSDKNSLPFFNSD
                     NCGGDNFYYPTKDKMEEAIDFWLKSYQTKWFVRWVIIDKISLKAIGTIELFNRTSEDKF
                     NGMGVLRLDLKSEYEKEEVIKEILELIVSPTYELFDCEEVITKVPNYAIERISAVSGIG
                     FTKSDNFLVGTHDRYSYKDYWTIHK"
     gene            complement(4709..4903)
                     /locus_tag="M0P28_RS07690"
                     /old_locus_tag="M0P28_07690"
     CDS             complement(4709..4903)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025565.4"
                     /locus_tag="M0P28_RS07690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07690"
                     /product="transposon-encoded TnpW family protein"
                     /protein_id="WP_220432036.1"
                     /transl_table=11
                     /translation="MAENEKLQSIETQTNKERATPQKPNGIMIKKIRGKTFVTEIYFNK
                     NSKETFQDKLLQVVKSEQK"
     gene            complement(4987..5277)
                     /locus_tag="M0P28_RS07695"
                     /old_locus_tag="M0P28_07695"
     CDS             complement(4987..5277)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007516553.1"
                     /locus_tag="M0P28_RS07695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07695"
                     /product="DUF3847 domain-containing protein"
                     /protein_id="WP_117479702.1"
                     /transl_table=11
                     /translation="MRKLEQIRQDSKEIKDKIDDTEERLRQLKNQEQKILKQDIVKRRK
                     ERTHRLITRGAILESLIENSEELTDEEIKILLEEATKTKEFKETLIIMREN"
     gene            complement(5382..5771)
                     /locus_tag="M0P28_RS07700"
                     /old_locus_tag="M0P28_07700"
     CDS             complement(5382..5771)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019116047.1"
                     /locus_tag="M0P28_RS07700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07700"
                     /product="VOC family protein"
                     /protein_id="WP_019116047.1"
                     /transl_table=11
                     /translation="MDFSRMIPELSVFDINLTKKFYSELGFKIEYERVEDKFVFMSFQE
                     SQFMFEQIHDDGWNIGELVYPLGRGINFSIAVDDIEELYQLVNNLNIELYRELTINIYQ
                     VNEIEEMQIEFLIQDPNGYLLRFTN"
     gene            complement(5791..6016)
                     /locus_tag="M0P28_RS07705"
                     /old_locus_tag="M0P28_07705"
                     /pseudo=""
     CDS             complement(5791..6016)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891898.1"
                     /locus_tag="M0P28_RS07705"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07705"
                     /product="CD1845 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTFLLGIGTALLYIIMVFCLFWALSSFIQGEVGIGIFGLVIGFLI
                     "
     gene            complement(6052..>6372)
                     /locus_tag="M0P28_RS07710"
                     /old_locus_tag="M0P28_07710"
                     /pseudo=""
     CDS             complement(6052..>6372)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000914584.1"
                     /locus_tag="M0P28_RS07710"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07710"
                     /product="23S rRNA (uracil-5-)-methyltransferase RumA"
                     /pseudo=""
                     /transl_table=11
                     /translation="QTTHVETVALLSKLDVDKHISVEIELDELDLTSAESKATYAQIKE
                     YVWNKFELKVPTLYIAQIKRKCGIELREHYNKSKKEKQIIPQCTPEKEEAIMDALRHFK
                     MI"
     gene            complement(6320..8110)
                     /locus_tag="M0P28_RS07715"
                     /old_locus_tag="M0P28_07715"
     CDS             complement(6320..8110)
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017767999.1"
                     /locus_tag="M0P28_RS07715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07715"
                     /product="recombinase family protein"
                     /protein_id="WP_117479704.1"
                     /transl_table=11
                     /translation="MKKNNVEIIKADSLVRRRGDNFERESKRVAAYCRVSSDSEDQKNS
                     YESQVRHYKDYISQRSDWELAGIYADEGISGTQVGKRQDFQRLINDCVNGEIDYIVTKA
                     IARFARNTLDTLKYVRMLKDMQIGVYFEEENIDTLTMDGELLLTILSSVAQQEVENTSA
                     HVKKGLKMKMQRGELIGFQGCLGYDYDVETKQLSINKKEAKIVRYIFERYLEGIGGKVI
                     ARELDELGYKSPRGLDHWNDTTVLGIIKNEKYKGDILMGKTFTVDPISKRRLSNFGEED
                     KYYIKDNHEPIISKEDFEKAQEIRLRRAGNKKTAANVNGKRERYSKMYAFSSMLECGFC
                     GSILSRRSWHCRSDYRKVVWHCVTSIKKGKKFCKHSKGLEELAIEGAFMEAYRKLYHSN
                     ENLMTDLLETIESELNDNSLNKELKRITNKLRTLLKKEENLVNLRLEGKISDTIYNEKY
                     NEISSEKEFLAEEKVNIETTLKSEIDVKKRLTEFKHLLSSQKMLTEFDRAVFESIVEKI
                     IVGGVNSDGEIDPAMLTIIFKTGETQNKDGKQFKSKRKNAKLETDKLCPQNSDEDKKLY
                     SQGTDYTCGDGSTFVQTRCR"
     gene            complement(8164..8265)
                     /locus_tag="M0P28_RS12085"
     CDS             complement(8164..8265)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042617.2"
                     /locus_tag="M0P28_RS12085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_306341358.1"
                     /transl_table=11
                     /translation="MQLSMLNFLYSRNMLTKKEYEKIKNRLRIKYTN"
     misc_feature    complement(8428..8438)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(8611..9015)
                     /locus_tag="M0P28_RS07720"
                     /old_locus_tag="M0P28_07720"
     CDS             complement(8611..9015)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018368528.1"
                     /locus_tag="M0P28_RS07720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07720"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_000878635.1"
                     /transl_table=11
                     /translation="MKYYIHVRGSKIPVTETVYKSYWQLVNHEKYLNRKDRKFGVLPFS
                     SFEVDGLLLANVLPDTTVDVERFIENKLLIEQLNEALLTLSDKEFKIIDALYFREHTIR
                     EVAIEHEMSATSLFRMRNTILDNLRKFFEK"
     gene            complement(9283..9999)
                     /locus_tag="M0P28_RS07725"
                     /old_locus_tag="M0P28_07725"
     CDS             complement(9283..9999)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001226539.1"
                     /locus_tag="M0P28_RS07725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07725"
                     /product="NisI/SpaI family lantibiotic immunity
                     lipoprotein"
                     /protein_id="WP_001226539.1"
                     /transl_table=11
                     /translation="MRKILFSLVVLIGICTLVACRLVDNKTIEFHDQSFNQFTYKGNDY
                     TIMNQIVDENDLGTVKESFFKTLVIDRNSQKVVTKSNSDTVSLAYSGLYNFSDGLAISI
                     NDSYYKVSLSSDVQSNNEMLSLEEFNNNSAGGELAIDPSDCRIVKFNNKKFRISSDIVS
                     DDKLKEFLGVIADSKTFILNTGQEISKSELNKIDYSGSNSNEKREVWDYGEVYLLAEEG
                     TIAVEINNEFRIARIE"
     gene            complement(10001..11278)
                     /locus_tag="M0P28_RS07730"
                     /old_locus_tag="M0P28_07730"
     CDS             complement(10001..11278)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000344171.1"
                     /locus_tag="M0P28_RS07730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07730"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_000344171.1"
                     /sec_met_domain="LANC_like (E-value: 2.8e-57, bitscore:
                     191.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDENKVIIDLSEKVFAKFDEQLKRYAEQPNYDLLTLSSGLPGLIL
                     LSSELTSLTSERKYSARTGKYVNFMVKQMRNYGVLSDSLFSGVSGIGISILHLVEEHPE
                     YHNLLISFNEYIKYYTLSKIENIDIKKISPTDYDIIEGVSGVLVYLLSQEQDENDYIIN
                     RIINFLSEFSLKNSTLTGFYVESKNQMSKTESKLYPLGCLNFGLAHGLAGVGAMLSYSK
                     LKGYSNEKSIAAIKKIIMLYEKHELKNYMWKEGLSDIELKKTEKSNLQYEFIRDAWCYG
                     SPGISLLYLYSSLALEDKKLKSKACNILKASIRRSNGLEQSILCHGFSGAIEICLFFKK
                     IYKTTDFDDCIKSLKEKLISDFREDMTYGFNTTAEFENIKTKDNLGYLDGIIGILLTMI
                     ELNNLKVTTNWQRALLLFDDVIKEVK"
     gene            complement(11271..13067)
                     /locus_tag="M0P28_RS07735"
                     /old_locus_tag="M0P28_07735"
     CDS             complement(11271..13067)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002943315.1"
                     /locus_tag="M0P28_RS07735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07735"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_031912841.1"
                     /transl_table=11
                     /translation="MDKFTLKNFFQTILTIPKTIRLIFRIERKYASYLIILNILQSIIP
                     LASLFIYQELINAVLKKGSNIFSVLIVYILMQMMLSILSQLNSYISEKFNMNLSYNLNL
                     KLLKKTSSLNLIDFEQADTYNLIENIVQDSTYKPFQLFNAIIGVITGFLSLLTSIIYVS
                     TWNVAVSTFLLIIPVISLVIFMRVGQLEFLIQWERANSEREVWYINYLLTHDFSFKEIK
                     LNGISQYFIDKYGTLKRNFMNQDLNISKKKVLFRGSLDILLNFINGIAIFMMIQSIRSG
                     KLLVGNFVSLIQAITRVNTYSQSMIQNTYIIYNTSLFMEQLFKFFDMEVSNISIQNSRI
                     SRIEKRIDKIKVNNLSFIYPGSVKKTLEDINVEFNKGELVAIVGKNGSGKSTLVKLLSG
                     LYQPSEGQIYYNNESSDVLDLSYYQNNVSVLFQDFVKFELSVRENIGLSDVNSISDSKI
                     KKHIDNLKLNFLTAENNFNLNQRLGTWFNDSRQISGGQWQKVALARTFFKNASIYILDE
                     PSSALDPVSEKEIFDEFVTRSRDKIALFVSHNLMAASRADRIIVMQDGRIIDEGKHDDL
                     ISKSKYYRELYYSEKYEEESDG"
     gene            complement(13060..14184)
                     /locus_tag="M0P28_RS07740"
                     /old_locus_tag="M0P28_07740"
     CDS             complement(13060..14184)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="M0P28_RS07740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07740"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_248488377.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.3e-21, bitscore:
                     72.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSKDIHQIILENNLPTKLYVDNSDNRILINRNNPLDNQLFEDIV
                     RKSSNKNEELCLSECIFDSHLVEKESTTHISDIVVPVFAKDEIKEPRYIKEILPEVIPT
                     NVRQKIPFDEWLYFKLYMSADRQEEFLSDIMPQILKLVNLDDGMSFYIRYTDPKFHIRL
                     RIRTQNLYKSFEKIQEIFQLCIQNKLISNIDISTYDREIERYGGLERIPLVEEIFCLDT
                     EIVINSLSLIRQKRLDLTLDDLAIIFNYFYLKSFFKDNNKEIIQFLEFACPEHLDSQNR
                     DKNRNTALIDLYLIKGYLINLLPELSKLCQRLKKLSDSCIQLSDDYTYIIYDSIIHVHN
                     NRLFGIKRENETKIYAIIRGLIISEEFRNGHNHG"
     gene            complement(14302..15407)
                     /locus_tag="M0P28_RS07745"
                     /old_locus_tag="M0P28_07745"
     CDS             complement(join(14302..15131,15131..15407))
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1026: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611996.1"
                     /locus_tag="M0P28_RS07745"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="M0P28_07745"
                     /product="IS3 family transposase"
                     /protein_id="WP_249551291.1"
                     /ribosomal_slippage=""
                     /transl_table=11
                     /translation="MSRKIRRHFTDDFKQQIVDLHNAGMKRSELIKEYELTPSTFDKWV
                     RQAKLTGSFKSVDNMTDEQRELIQLKKRNKELEMQLDILKQAAVIMAPKRQVITANKDK
                     YSISAMCRWLNIPRSSYYYQAVNPVSEADLEDKITYIFLESKSRYGARKIKKCLEKDGI
                     ILSRRRIRRIMKRLNLVSVYQKAAFKPHSKGKNEAPIPNRLDRQFDQERPLEALVTDLT
                     YVRVDRRWAYVCLIIDLFNREIIGLSVGWHKTAELVKQAIQSIPYALTKVKLFHSDRGK
                     EFDNQLIDEMLEAFGITRSLSQAGCPYDNAVAESTYRSFKLEFINQETFQSLEELALKT
                     KDYVHWWNYHRIHGSLNYQTPMTKRIIA"
     gene            complement(15460..17256)
                     /locus_tag="M0P28_RS07750"
                     /old_locus_tag="M0P28_07750"
     CDS             complement(15460..17256)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400478.1"
                     /locus_tag="M0P28_RS07750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07750"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_248488370.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.2e-77, bitscore:
                     256.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 9.4e-07,
                     bitscore: 26.6, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHKYTTNNFLVRNAIIGIHELLECDYNSFLETIRENKIFQEQLF
                     VASRSLYESLQKYYSGDSMKRKKINQLSESVYKYYKRSKERSTPFGLFSETSIGSFSST
                     EKLNLNGKTLKKVLLDSEWLIRLVFKIEKEYSRELAYKINPANYQFGDRVVQLFSINDT
                     KIEEVNIKFTKVYQLIDELCCDKYVYFNCIIEKLVESYGEEYRDIATSYIMSLIDSHFL
                     ISNINSELIMNFKFEEFISKVKEIDKQNLYYFKLIAISNLIVEYSELEIGDGIEKLKEI
                     YKLMSSLVETPNFLQIDLYNDGQIQLGNENKTQIVEFAEFLVSNSDHVKRTYLDDYKEK
                     FLDKYGVNREVQLMELFDSNLGIGSPYGYQHPKNDFWESSPSTVYFSEKEELEYLNNFE
                     KALETGGNIQLYNEEDFFNQDKDKINLGFELFFYVNKVDGKSVLSLTNTGCSKNLGASS
                     GRFSILSGKLEHYHQTITQIVENNNHVSGYNSCEITFLPENLRHANVMRTTNVREKVLS
                     LFTNMDKRSQILSDIYIGIDSKNSFYARNFKTKELLKFYSTNMYNQMMFSNELRFLCEI
                     AQEDHFGIFPWEMVYQKLNRLH"
     aSDomain        complement(16579..16824)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_M0P28_RS07750_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.10E-08"
                     /identifier="RREFam001.1"
                     /label="M0P28_RS07750"
                     /locus_tag="M0P28_RS07750"
                     /protein_end="226"
                     /protein_start="144"
                     /score="26.6"
                     /tool="antismash"
                     /translation="PANYQFGDRVVQLFSINDTKIEEVNIKFTKVYQLIDELCCDKYVY
                     FNCIIEKLVESYGEEYRDIATSYIMSLIDSHFLISNI"
     gene            complement(17497..17664)
                     /locus_tag="M0P28_RS07755"
                     /old_locus_tag="M0P28_07755"
     CDS             complement(17497..17664)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_a"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001058290.1"
                     /locus_tag="M0P28_RS07755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07755"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_001058290.1"
                     /sec_met_domain="TIGR03731 (E-value: 6.5e-22, bitscore:
                     74.4, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_a (E-value: 5.1e-06, bitscore:
                     22.8, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNEDFNLDLVTISKENNSGASPRVTSKSLCTPGCKTGILMTCAI
                     KTATCGCHFG"
     CDS_motif       complement(17593..17664)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNNEDFNLDLVTISKENNSGASPR"
                     /locus_tag="M0P28_RS07755_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(17497..17592)
                     /prepeptide="core"
                     /locus_tag="M0P28_RS07755_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="27.40"
                     /molecular_weight="2989.6"
                     /monoisotopic_mass="2987.5"
                     /core_sequence="VTSKSLCTPGCKTGILMTCAIKTATCGCHFG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNNEDFNLDLVTISKENNSGASPR"
                     /leader_location="[17592:17664](-)"
                     /alternative_weights="3007.6"
                     /alternative_weights="3025.7"
                     /alternative_weights="3043.7"
     gene            complement(18012..18698)
                     /locus_tag="M0P28_RS07760"
                     /old_locus_tag="M0P28_07760"
     CDS             complement(18012..18698)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001033677.1"
                     /locus_tag="M0P28_RS07760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07760"
                     /product="hypothetical protein"
                     /protein_id="WP_001033677.1"
                     /transl_table=11
                     /translation="MNKILKSELLKLKGSLTLNLILILSIIQLFTIPLYLQFTNNSVVI
                     ENIIFLPMLGYCILASIFSIFLHEQEEKANFFQNIKSEKNSGIIWGIKLISTDLLMVLL
                     GVPVWIVVGVEFNRLSYFAYVGVITWLLLVLLNHFHMLLSLIMGKGGNLVISFIECLFI
                     IFATNKVFLNNFWLPIVLPVNMILEIGKNEIFMILVYLIGFIILSYFCNLAVMNNVEIQ
                     KICKKR"
     gene            complement(18676..19413)
                     /locus_tag="M0P28_RS07765"
                     /old_locus_tag="M0P28_07765"
     CDS             complement(18676..19413)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013851902.1"
                     /locus_tag="M0P28_RS07765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07765"
                     /product="lantibiotic ABC transporter permease"
                     /protein_id="WP_000181737.1"
                     /transl_table=11
                     /translation="MTNIFKSEWLKQKSSSDKKLLILIPLLAIFIAFILAGPLNLESFS
                     IYWWEGGFLFTLLGLLFLADYSAEENAGAFQNISLGRYTFTIYLAKILLKFKDVLISTF
                     IFTIIFYGISFLFSGVISVDIGKDLICLLLIGVSSAWVLPLLYFLAKWINPYLLLATNS
                     LICLLVAPLIAQTSVWFIFPYTYHYKIAYALLHLKPSGDLEAALSGVEISTILISVSLS
                     ILVFVSFLSLLKWRITNEQNSKK"
     gene            complement(19406..20107)
                     /locus_tag="M0P28_RS07770"
                     /old_locus_tag="M0P28_07770"
     CDS             complement(19406..20107)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000452012.1"
                     /locus_tag="M0P28_RS07770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07770"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000452012.1"
                     /transl_table=11
                     /translation="MEVIIQNLRKSYKDKEVLKDVSFKIEEGTICGLLGVNGAGKSTIM
                     KILFGLERADSGEVIFNGKHKDIVEENRFDIGALIESPAIYLNLSAFDNLKTRALLHDI
                     PDERIYEVLQLVGLSDTGKKKAGHFSLGMKQRLGLGMAIITNPDLLILDEPTNGLDPDG
                     IKELLNLIRDLKKSGMTVLLSSHQLSEVSKIADQIVILNQGKIFYDDINKNSNDLEKLF
                     FRIVHGGDGND"
     gene            complement(20297..21640)
                     /locus_tag="M0P28_RS07775"
                     /old_locus_tag="M0P28_07775"
     CDS             complement(20297..21640)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000977994.1"
                     /locus_tag="M0P28_RS07775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07775"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_000977993.1"
                     /transl_table=11
                     /translation="MMKRYSINKRILRTVLEIVIGTVANVIMLLVLSYVLIFTGQLNTY
                     GTDYHISISDSKSANGIKNQMDYSVFDYVLFDSDNGELVSGNYQKQDLQHYKEVFDTGS
                     SVSEGSILFTKYENSDFILVIRRPTMPEFVNRNFRHISYNLVSYLFFIVLELLLISISV
                     IRLLREFTKNFRLIEKISLNMGIPGMDIGRKETAILECNNILLTLYQKDEELTKLLEME
                     KKDKEDLSFQVAALAHDIKTPLTVLKGNIELLEMTNLDEKQLDFMSSMNHSVGIFEKYF
                     NSMVNYSRLLIEDKNYQEDIELSKFLDELSLECRDIMSSKKINFQIVNESHTRVIKGNR
                     LNLDRALINILSNATRFCSEEGKVVLTISESSNFISFEIWNNGLPFTEESLKDGGKLFY
                     TENKGRNDKHYGIGLSFAQKIAMRHQGQLILSNPQNGGAQVTLLIKKF"
     gene            complement(21618..22316)
                     /locus_tag="M0P28_RS07780"
                     /old_locus_tag="M0P28_07780"
     CDS             complement(21618..22316)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000276750.1"
                     /locus_tag="M0P28_RS07780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07780"
                     /product="response regulator transcription factor"
                     /protein_id="WP_000276751.1"
                     /transl_table=11
                     /translation="MYKILVVDDDFEIVKLMRTILEMKNYNVTTYQEVRLPIKISDFDG
                     FDLILLDVMMPNVDGLQICKQIRKSVSSPIIFVSAKDSEDDIVSGLNLGGDDYITKPFS
                     VNQLVAKVAAHLKREERYRNAESNESVIRELFPLTFYLQEKLVCVNGEAISLTKREYDI
                     LELLSSKTNKVYTREEIYECVYGDEADALFRSISEYIYQIRVKFGPYGINPIKTIRGMG
                     YKWNDEKVFN"
     gene            complement(22357..23730)
                     /locus_tag="M0P28_RS07785"
                     /old_locus_tag="M0P28_07785"
     CDS             complement(22357..23730)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000719507.1"
                     /locus_tag="M0P28_RS07785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07785"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_000719507.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 5.6e-37, bitscore:
                     124.7, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIGLLSNVFISLFIVILASGSVSSGVSANENKEISYNVLVSEN
                     KSIEDVEDVLQSQGIKVTDKIPEINFLTISTEKSEDTIKKENSNYIDDIVIDNTMTVKP
                     NITYLYGDKVYTNTNLDFWGNQWDMQKSISTGSKFQHKSSGKATIGVIDSGITYDNPDI
                     YSHIISVQNFTSDLETGIVDNQNVVDKIGHGTSVVGQISSSGEYLGIAPDMKIRMYRVF
                     DEGNAQDQWILKALIQAAKDDVDVINLSLGEYLLRDSTDEDDDTALINIYQRAINYAHN
                     QGSVVVASVGDEGMDLQNQDELKNYLGSLRGKDYSQVDGTVQDIPAELDNVVTVGSVDD
                     NDLVSSFSNQGNGDIDIYATGGGSQALSKVGYDKWVADKLYEKEWILVPTLEGKYTYAY
                     GTSISTPKVSAALGLIIEKYNLKDQPDEAIRILYDNCFLSNNGNNGQIRLLNITNFVQ"
     gene            complement(23827..25710)
                     /locus_tag="M0P28_RS07790"
                     /old_locus_tag="M0P28_07790"
     CDS             complement(23827..25710)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000261812.1"
                     /locus_tag="M0P28_RS07790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07790"
                     /product="SAG1250 family conjugative relaxase"
                     /protein_id="WP_000261812.1"
                     /transl_table=11
                     /translation="MVVTKHFAVHGNKYRKSLIKYILNPAKTDQLKLVSDFGMSNYLDF
                     PNYEEIVEMYQANFVNNDRLYDSRNDRQQIKQNKIHAHHLIQSFSPEDNLTPEEINRIG
                     YETIKELTGGNFRFIVTTHTDRLHVHNHILINSVDLNSHKKLKWDYAQERNLRMISDRL
                     SKEAGAKIITPNRYSHEKFVTYRKSNHKFELKQRLYFLMENSKDFDDFLSKAEALNVQI
                     DFSRKYARFLMTDMPMKRVIRGKQLDKRQPYTEEYFREHFAKRAIEQCLDFLLPRVRDL
                     SQLLEFARELNLAMSLKQKNVAFTLTKNSQSITVNNQKVSSKNLYDVQFFETYFEKRGE
                     VPDIDQSQLISDFEGYCEEQDKEKLAYEDLQEAYQAFKEKRDQVQEFDVVLADHQIDKL
                     VKDGLFIRMNYGVKKDGLVFIPNRHLDIKETESGKHYHAFIRETAQFFIYNKEASELNR
                     YMRGRELIRQLTNDSQTISKRKRPTIDTLKKKIEEINLLIELGTENKSYQDIKDEIIKD
                     IAQLDLTITEIQEHIDHLNKVAEVLLNLDNNDIENRRLAKYDYAKMNLTAAIKLEQVEK
                     EIEIYQIKLDKSIDDYEYLIRRLEKFVKILNEIDSSKDELKFEHSEKNVKE"
     gene            complement(25697..26062)
                     /locus_tag="M0P28_RS07795"
                     /old_locus_tag="M0P28_07795"
     CDS             complement(25697..26062)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000263054.1"
                     /locus_tag="M0P28_RS07795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07795"
                     /product="MobC family plasmid mobilization relaxosome
                     protein"
                     /protein_id="WP_000431640.1"
                     /transl_table=11
                     /translation="MENRYRTNLKKVFLTDQELANLNNHISQSSCQNFSAYARKVLLNP
                     NMTFLTIDTSNYQDLVFELRRIGNNINQIAKTVNQTKLLTVEQRDNLKTGIGQLIAEVD
                     KDFYVKCQKLREFYGSH"
     gene            complement(26065..26427)
                     /locus_tag="M0P28_RS07800"
                     /old_locus_tag="M0P28_07800"
     CDS             complement(26065..26427)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013851909.1"
                     /locus_tag="M0P28_RS07800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M0P28_07800"
                     /product="SAG1252 family conjugative relaxosome accessory
                     protein"
                     /protein_id="WP_000140674.1"
                     /transl_table=11
                     /translation="MTESYRTIRKEINLTLEEFEQIQLLMRKENAEQFSPFVRQKLLDI
                     VNNKDDIRDWFILWQSQKIEQISRDILQVATLAERGHQVTSEHLRIILTCVQELMTEVE
                     KAVPLSSEFRDKYMGG"
     misc_feature    complement(26535..26549)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 19.31"
                     /tool="antismash"
ORIGIN
        1 aaccacaact ttgtcaacgt gtgcaactac aatttctttg cttaacttct tgtcagttgg
       61 caactgaaca aagttcgctt ctttcaactg ctcttccaaa tcctgaacaa atttatccat
      121 ttcctttttc ttgacaatat aatcttctct ggtcaacagg ttatccttgt agtcctgaaa
      181 gcaggcgagt ttttctgtct tcaatcgttc aatttcccga agaacaaggg tcttagatac
      241 cttttgatga ggttttactg catcatctcc tagtttccct ttgattgctt gttcaatcct
      301 atccactcga caagacttca ttctttctcc ctccccctta caataacgac aggaaaaata
      361 ttggtaacct tgatggttgt agtgtccaat caaagaatga ccacagtgct cacaacgaat
      421 cagacctgtc aatacagacg atgttttcgg tatctgatgc tgttttcttt tagtggcttt
      481 taaggctttt aattgaacaa cttgctcaaa tagttctgat aaaataatcg cttcgtgatt
      541 gttctcaatc cgctcccact ctgattttgg tctgaagaca tgcttccccc ttacatacgt
      601 ccgagtatta aaaagataag ttcccttata ggcttcattc tttaaaattt gaccaacggt
      661 agtgctactc caaacatttc atttttgctc agttgttaaa cggagtgact ttgtgtagcg
      721 tgcctgactg atttgcatct ttcgttctgc tggagtaatg acttgttctt aattcaggag
      781 tcgagcaatt gtttggtaac tattaccatc aaggtacaag gcgaaaatcc gtctaacaat
      841 tggtgcaact gtctcgtcaa taataatctt gaaacgatcc cctggatcct tgagataacc
      901 aaatgggggc aaccagctca tgtttttgcc cgagcgtttc atgctgttca tcgcactctt
      961 gaccttttcc gagacatctt tggtatagaa atcattgagt aaattccgaa aaggcacatc
     1021 aataaccagt ccattctgtt cagacgtcaa actgtcatag tggtcactga gagcgatgaa
     1081 gcgaaccaca agaaaagtaa agatattttc caaatagttc cctaactaca gataatcacg
     1141 cataaatcga gacaagtctt taacaaggat atgtcggata gttcccacct tcacagcagc
     1201 catcaaccgt tgaaaagatg gacgattcag gcttgttcct gaaaaaccat cgtccacaaa
     1261 ttccaagcgc tcccaattct taaactcagg tgtttggtca agataatggt ttaacaagta
     1321 ccgttggttc gtaattgaat tgctttcatc tttatcagcc tcatcgacag atagtctaag
     1381 atataaagcc actttagaca ttgtctgcgc ctcctatctg acagcgacaa gcaatcgtta
     1441 cttctttatt cacgtcaact tcgatgcgtt cgataattgc ctgtaatagt tccgaggtta
     1501 gagtctctgt tccttggcat tgagttagcg attttaccca acttatctgc ttctgatgtt
     1561 cttcttccaa gttgcccaat agccacctca caatgtctta tttcctgcga aagtgtctca
     1621 atttgagctt ccttttcaga tttttgagtg agataggttg ctttttcagt ccgtaccaaa
     1681 ctatatgaag catataagtc acttatttct tctcgtaatc gcaagatagc ttgttggtgt
     1741 tgccttactt gcctataata aaccttaata caatcatctg aaaaggcaac acttttctga
     1801 acaattttta taaagtgctt tttaagcgat aattcgtttg gtcatgggcg tttggtagtt
     1861 aagactacca tgaatgcgat gatagttcca ccagtgaaca taatctttcg ttttgagggc
     1921 taattcttct aacgactgaa aggtttcttg gttgataaac tccagtttga aggaacgata
     1981 ggtactttca gcgacggcat tatcataggg acaaccagct tgactgaggg aacgggtgat
     2041 tccaaaagct tcaagcatct catcaatcag ctgattgtca aactccttgc cacgatcaga
     2101 atggaacaac ttgaccttgg ttagtgcata agggatgctt tgaatggctt gtttaacgag
     2161 ctccgcagtc ttgtgccagc caacggttca cgattaaaga ggtcaatgat gagacaaacg
     2221 taagcccagc gcctatccac acggacgtaa gtcaagtcgg tcaccagggc ttccagtggt
     2281 ctttcttgat cgaattgcct gtctaggcgg tttggaatag gagcttcgtt cttcccttta
     2341 gaatgcggtt tgaaggctgc tttttgataa acggatacca agtttaggcg cttcatgatg
     2401 cgacgaatcc gacggcgaga gagtatgatg ccgtcctttt ctaagcattt cttgattttt
     2461 ctagccccat atctggactt gctctcaagg aaaatatagg taattttatc ctcgagatca
     2521 gcctctgaca caggatttac agcttggtag tagtaacttg agcgcgggat gttcagccaa
     2581 cgacacatag ctgaaatgct gtatttatcc ttgtttgcag tgattacttg tcttttcgtg
     2641 ccataatcac tgccgcttgc tttaggatgt ctaattgcat ttcgagttct ttattgcgtt
     2701 ttttgagttg aatcagttcc cgttgttcat ctgtcatatt atcaacagac ttgaaggaac
     2761 ccgttagttt ggcttgtctg acccacttat cgaaggttga gggcgttaac tcatattctt
     2821 tgataagctc acttcgtttc attccagcat tgtggaggtc aacaatttgt tgtttaaagt
     2881 catcggtgaa gtggcgacgt atttttctag acatatctgt tctcctgttt tctttagtgt
     2941 agaacacttt ataaattctg tctagtttag tgtaaccgat tcaaggcaat attatatttt
     3001 ttactaatac tttttctttt cttgtatagt catgggttac tccgtcccat tcatttttta
     3061 ttttttctcc acttatatat gctgcacttg ctactgcact tttgcctttt cctcttgata
     3121 ttatgtttac tgaaaaatga aaactgtctg ccatttttat cacttccttt ctttttttgt
     3181 tgtttcaccc taaagggtac aagtaggtgg aggcttaata gatttttata gccactttgt
     3241 gaatgagcgt tttgaaatac cctttgccta atcattcaat ccactcgcaa gctcgtggtg
     3301 aatgattggc aggggcagac cctgatagaa ttaaaaaagc cgactactga attaattttt
     3361 gttgtttcag tatgtcggct taattgtttt gttcatttca aattttaaaa gtcaagggcg
     3421 agcgttagcg agtttattta cccttggact tttaaaaagc gaatggttgt tgctccctgc
     3481 aagggtttgg ctccgcagga cgcaagcacc ctttagggtg tataattgcg cccttgtaaa
     3541 caagggacta ttcctctgtt tccgttactt cttattgtgt ttctgtaatt ttgttttcgc
     3601 tttgtcttcg attatctatg attttttgta ttttttgatt tactgcttct ttgacatttg
     3661 ggaatgtgat tagctgataa aattcatctt tggtaaaatc cttgctttcg ttaaagatac
     3721 tttaaaatac tcctcctttt tcataaaggc gtctatctct tttcttacgt tcttcctgtt
     3781 tctgtttact gattagcttt tttcttttgt tttgtaactg cttgatttct tcttctgcca
     3841 ttaaaatttt ttcatctatg tttttcattt tctgtttccc tctctttcaa attttaagca
     3901 aagaaaaaac agtaaaccga tttgatttac tgtttccttg aattttaact atattttttg
     3961 ttaatctact attttttatt tatgaattgt ccaataatct ttatatgaat atctatcatg
     4021 cgttcctact aaaaaattat ccgattttgt aaaaccaatt ccggatacag cagatattct
     4081 ttcaatggca taattaggaa ctttagtgat aacttcttcg caatcaaata gttcataagt
     4141 tggcgaaact ataagctcta aaatttcttt aataacttct tctttttcat attcgctttt
     4201 caaatccagt ctaagtacgc ccattccatt aaacttatct tctgatgttc tattaaacag
     4261 ttcaatagtt ccaatcgctt ttaatgaaat cttatcaatg ataacccaac gaacgaacca
     4321 ttttgtctga tatgatttta gccaaaaatc aatagcttct tccatcttat cttttgttgg
     4381 atagtaaaaa ttatccccac cacaattatc actattaaaa aatggcaatg aatttttgtc
     4441 actataaact gcgaataaat cttctacatc atctttatct acaaatcgga gtaaaaattt
     4501 ttcactttca aatttaggaa cattcttata tatatttgac atagtttagt tctcctaacc
     4561 aatatatctc tcctcgaatt tgttatatgt tataccattt ttaagccatt ttttcaaccg
     4621 tcagatttcc tgcttgcttt caggacttcc acaaaaacag atatgaaaag aatagtaata
     4681 tcgttattaa gggggctatt tcaccttatt atttctgttc cgatttcact acctgtaaca
     4741 gcttatcttg aaatgtttct ttactgtttt tattaaaata tatctccgtt acaaaggtct
     4801 tccctctaat cttttttatc ataataccat tcggtttttg gggtgtggct cgttctttat
     4861 tggtctgtgt ttcaatgctt tgtaattttt cattttctgc catttaatcc tcctttcgac
     4921 ttgcacaaaa aaagatttcc tgtgattagg aaacctcttt tcatattggt tgatatatta
     4981 tttttcttaa ttttctctca ttattattag tgtttcttta aattcttttg tctttgttgc
     5041 ttcttctagt aggattttta tttcttcatc tgttagttct tctgaatttt ctataaggct
     5101 ttctaagatt gctcctcttg ttatgagcct atgagttctt tcttttcttc tttttactat
     5161 gtcttgtttt aatatctttt gttcttgatt ttttagttgc cttaatcttt cttctgtatc
     5221 atcaatttta tcttttattt cttttgaatc ttgtcttatt tgttctaatt ttctcatact
     5281 tatctccttt ctttaaaata aaaaagacga cagaattatt actttctatc gtcttgtatc
     5341 tttagtattt agttttattt agctcgacaa actggtattt tttaatttgt aaatcttaac
     5401 aaatacccat tgggatcttg aattaaaaac tctatttgca tttcttctat ttcattaact
     5461 tgatatatgt ttatggttag ttctctgtat aattctatat tcaaattatt cactaattga
     5521 tacagttctt caatatcatc gacagctatt gaaaaattta ttcctcttcc taaaggatat
     5581 actagctcgc ctatattcca accatcatca tgaatttgtt cgaacataaa ctgactttct
     5641 tgaaaagaca tgaaaacgaa tttatcttca acacgttcat attcaatttt aaatcctaat
     5701 tcactataaa attttttagt cagattaata tcaaaaactg ataattcagg aatcatccta
     5761 ctaaaatcca tattccctcc ttgacaaata ctaatttatc caaaccgctt taattttatc
     5821 atttatcaat tcaataaacg ctatcacagt tactcctact ttcggaagtc cgtaaggact
     5881 aaattagaaa accaataacc aagccaaaaa tacctattcc gacttctcct tgaataaaag
     5941 aagataacgc ccaaaataag cagaacacca taatgatata caacaacgcc gttccaatac
     6001 caagtaggaa tgtaataaat gcagaaagtc atatgctgtc attcttttct attaaatcat
     6061 tttgaagtgt ctcaaagcat ccatgatggc ttcttctttt tcaggtgtac actgtggaat
     6121 aatttgtttc tcctttttag acttgttgta atgttctcgt aattctattc cacatttcct
     6181 ttttatctgt gcaatatata atgtcggaac ttttaattca aatttattcc aaacatattc
     6241 tttgatttga gcatatgttg ccttgctttc agcacttgtc aaatcaagct catccagctc
     6301 aatttcaaca cttatgtgct tatcgacatc gagtttggac aaaagtgcta ccgtctccac
     6361 atgtgtagtc tgttccttga gaatacaatt ttttatcctc gtcactgttt tgaggacaca
     6421 atttatctgt ttctagttta gcatttttac gtttactttt aaattgttta ccatccttgt
     6481 tttgagtttc acctgttttg aatattatgg ttaacattgc aggatcaatt tctccgtcgc
     6541 tattaactcc acctacaata attttctcaa caatactttc aaaaactgca cgatcaaact
     6601 ccgtaagcat tttctgtgaa gatagcaagt gcttaaactc agttagtctt ttctttacat
     6661 cgatttctga ttttaaggtt gtttcaatat ttaccttctc ttctgctaga aactcttttt
     6721 ctgaggaaat ttcattgtac ttttcattgt atatggtatc gctaattttc ccttcgagcc
     6781 ttagatttac aagattttcc tcttttttta gtaatgttcg aagtttgttt gtaatccttt
     6841 ttagttcctt attaaggcta ttgtcattca attcagattc aatcgtttca agtaagtctg
     6901 tcattaagtt ttcatttgaa tgataaagtt ttctgtaagc ttccatgaaa gccccctcaa
     6961 tagcgagctc ttctaatcct ttactatgct tacaaaattt ctttcctttc tttatcgatg
     7021 taacacagtg ccacacaacc ttgcgataat ctgaacggca gtgccaactt cttctagata
     7081 atattgaacc acaaaaacca cattctaaca tgctactaaa agcatacatt tttgaatagc
     7141 gttcacgctt gccatttaca tttgcagcag tcttcttatt tcctgctcga cgaagtctta
     7201 tctcctgagc tttctcaaag tcttctttag atattatagg ttcatgatta tctttgatgt
     7261 agtacttatc ttcttcacca aaattactta aacgtctctt gcttattgga tccactgtaa
     7321 aagttttgcc cattagaata tcgcctttat atttttcatt ctttatgatt cctaagactg
     7381 ttgtatcatt ccaatgatct aatcctctcg gcgatttgta acctagttca tcaagttccc
     7441 ttgcaattac ttttcctcca ataccttcta agtacctttc aaagatatag cgaactattt
     7501 tggcttcttt tttattgatt gaaagttgct tggtttctac atcatagtca taccccaagc
     7561 atccttgaaa ccctatcaat tcaccacgtt gcatcttcat ttttaatcct tttttcacat
     7621 gagcagatgt attttctact tcttgctgtg caacggagct tagaatagtc aaaagcaatt
     7681 ctccatccat tgttagggta tctatatttt cttcctcaaa atatactcca atttgcatat
     7741 cttttaacat tctgacatat ttcaaagtat ctagggtatt cctggcaaat ctagcaattg
     7801 cctttgtgac aatgtaatct atttctccat ttacacaatc atttattaat cgttgaaaat
     7861 cttgtctctt tcctacttgt gttcctgaaa tcccctcatc tgcatagata cctgccagtt
     7921 cccaatccga ccgctgagag atataatctt tataatgtct cacctgagat tcatagctgt
     7981 tcttctgatc ttcgctatca gaactaactc ggcaataagc agcaaccctt tttgactctc
     8041 tttcgaaatt gtcgcctcta cgacgaacta aagaatcagc ttttattatt tcaacattat
     8101 tttttttcat actgaaattc ctccttttga ttctatatta ccgcgttcaa atcaaaaggt
     8161 cagctaattt gtgtacttaa tgcgcagtct atttttaatt ttttcatatt cctttttagt
     8221 caacatattt ctggaatata aaaaattaag cattgaaagt tgcatactat attttactac
     8281 tgattgttcc aaaacttacc ctcctgataa catgttactc ttagttattc tctgtgggta
     8341 tgactggtta tatcaatcat gggaatttca cccgctgtcc ttttacgttg gcagcctgaa
     8401 cggtcagaag tatcattatc attatttgtg tcatggcaga taggtcacca tcctattttt
     8461 gaataaatga tttccgctca tttcctggcg cattacattc tattgctcaa caaataaagt
     8521 cccacctaga attattcaat tgtcaaaggg caaaaagaga ctaaaaattc ctctcactat
     8581 aaagagtgaa ttttttagtc tcctgtttcc ttatttttca aaaaattttc gtaggttgtc
     8641 caaaattgta tttctcatcc gaaatagact agtcgcagac atctcatgct ctattgctac
     8701 ttctctgatg gtatgctctc taaaatacag agcatcaatg attttaaact ctttatcaga
     8761 taaggttaat aaagcctcat ttagttgctc aataaggagc ttgttttcta taaaacgttc
     8821 aacatcaaca gttgtatcag gcagtacatt tgctagcagt aacccatcta cttcaaatga
     8881 tgaaaaaggt aatactccaa atttcctatc ttttctattc agatacttct cgtgattgac
     8941 caattgccag tagcttttat aaaccgtttc tgttacgggg attttactac ctctaacgtg
     9001 aatataatat ttcatttcag cctccgttta tgattttttc ttagtcataa aaggagggct
     9061 ccttatctca accatagcta tttctcactt ttatcaaatc aaggagttct cctcactata
     9121 agagtgaaaa tatggtgctc ttgttccaaa aaaaattata tgtaccaaaa aacagcaagc
     9181 tcttctgaac ttgctgatct atattttaat aagtttctgt ttagtaggta acaataagat
     9241 attttgctat ataagcaatg taatacctag ataatctata atttattcta tgcgcgctat
     9301 tctaaattca ttattaatct caacagctat ggttccttct tctgctaaca aataaacttc
     9361 tccgtaatcc caaacttctc ttttttcatt agaattagaa ccagaataat ctattttatt
     9421 tagttccgat ttagaaattt cttgtcccgt attcaaaata aatgtttttg aatctgctat
     9481 tactcctaga aattctttta gtttatcatc agatacaata tcagatgaaa tacgaaattt
     9541 tttattatta aatttaacta tcctacaatc agatggatca attgcaagtt ccccacctgc
     9601 tgaattatta ttgaactctt ccaagctcag catttcatta ttggattgca catccgaact
     9661 caaagaaacc ttataataag aatcatttat agaaatagct aaaccatcac taaaattata
     9721 gagcccacta tatgctaatg atactgtatc actattactt ttagtaacaa ctttctggct
     9781 atttctatca attactaatg ttttaaaaaa agattccttc acagtaccta gatcattttc
     9841 atcaacaatt tgattcatga ttgtataatc atttccttta tatgtaaatt gattaaatga
     9901 ttgatcatga aactctattg ttttattgtc taccaatcta catgcaacta aagtacaaat
     9961 tccaataaga acaactaagc taaataaaat tttcctcatg ctacttcacc tcctttataa
    10021 catcatcaaa taataagagt gccctttgcc aatttgttgt aacctttaag ttatttagtt
    10081 cgatcattgt taacagaatt ccaattattc catctaaata accaagatta tcttttgttt
    10141 ttatattttc aaattccgcg gtagtattaa aaccatatgt catgtcttct ctaaaatcac
    10201 taattaactt ttccttaaga gattttatac agtcatcaaa atcagttgtt ttataaattt
    10261 ttttaaaaaa taggcaaatc tcaattgctc cagaaaatcc gtgacataaa atagattgtt
    10321 ccaaaccatt acttctcctg atggatgctt tcaagatgtt acaagcttta gattttagtt
    10381 tcttatcttc tagagccaaa cttgaataca gatatagtaa actaattcct gggctaccgt
    10441 agcaccacgc atctcgaata aattcatact gtaaattgct tttttctgtt ttctttagtt
    10501 caatatcgct taatccctct ttccacatat aattttttaa ctcgtgtttt tcgtataaca
    10561 ttataatttt tttgattgct gcaatagatt tttcattaga atagcctttt aattttgaat
    10621 aagacaacat tgcgccaaca cccgcaaggc cgtgtgctaa accaaaattt agacatccta
    10681 acggataaag cttagactct gtcttggaca tttgattctt tgattccaca tagaagcctg
    10741 ttaaagtaga attttttagt gaaaactcag ataagaaatt gataattctg tttattatat
    10801 aatcattttc atcttgctcc tgagataaaa gataaactaa tactccagat actccttcta
    10861 tgatgtcata atctgtagga gagattttct taatatctat attttcaatc ttacttaacg
    10921 tatagtactt aatgtactca ttaaaactaa tcaataagtt atgatattct gggtgttctt
    10981 caactaaatg aagtatactt attccaattc cagaaactcc tgaaaataaa gaatccgata
    11041 aaacaccata atttctcatt tgtttaacca taaagttaac atatttaccc gttctagcgg
    11101 agtattttct ttcactagtt aaacttgtca attctgaaga taataatatc aatccaggta
    11161 aaccagaaga caaggtcaat aaatcataat tcggttgttc agcatatctt tttaactgct
    11221 catcaaattt agcaaatact ttctcagata aatcaataat aactttattt tcatccatca
    11281 gactcctcct cgtacttttc tgaatagtaa agttccctat aatatttaga tttacttata
    11341 aggtcgtcat gttttccttc atcaataatt cgtccatctt gcataactat aattcgatct
    11401 gctctactcg cagccattag attatgtgac acaaacaaag caatcttatc tctagaacga
    11461 gttacaaatt catcaaatat ttctttctct gaaacaggat caagcgctga acttggttca
    11521 tccaaaatgt atatgcttgc attcttgaag aaagtcctag ccaatgctac tttttgccat
    11581 tgtcctcctg aaatttgtct actatcgtta aaccaggtcc ctaaacgttg attaaggttg
    11641 aaattgtttt ctgcggttaa gaaatttaat tttaagttat caatatgttt ctttattttg
    11701 gagtcagata tactgtttac atcacttagg ccaatatttt ctctcacaga taattcaaac
    11761 ttcacaaagt cctgaaaaag aacagaaaca ttattttgat aataactcaa gtctaggaca
    11821 tcactagatt cgttattata atatatttga ccctctgaag gttggtataa tcccgatagt
    11881 aattttacta aggtactctt accagaacca ttcttcccca caattgctac aagttcaccc
    11941 ttattaaact caacattaat atcctctaaa gtttttttga cacttcctgg atagataaaa
    12001 gagagattat tgacttttat tttgtcaatg cgcttttcaa ttcttgagat tctactattc
    12061 tgaattgaaa tattacttac ttccatatca aaaaatttaa ataattgttc catgaataaa
    12121 cttgtgttat agatgatata agtattttgg atcatagatt gtgagtaggt atttacacga
    12181 gttattgctt gaataaggct tacaaaatta cctactaaaa gtttaccgct tcgaattgac
    12241 tgtatcatca taaaaatagc tataccatta ataaaattca ataaaatatc caaacttcct
    12301 ctgaaaagaa ctttcttttt cgaaatattc aaatcctgat tcataaaatt tcttttcaat
    12361 gttccatatt tatcaatgaa atattgacta ataccattta gtttaatctc tttaaatgaa
    12421 aaatcatgag taagaagata attgatgtac caaacttccc tctccgaatt tgctcgctcc
    12481 cattgaatca aaaattctag ctggccaaca cgcataaaaa ttactaagga aataacagga
    12541 attatcagta aaaaagtcga tactgccaca ttccaagtgg acacataaat aatacttgtt
    12601 aataaagata gaaaccctgt aatcacacca atgatagcat tgaaaagttg gaacggctta
    12661 tatgtactat cttgtacaat attttcaatg agattgtatg tatctgcttg ttcaaaatct
    12721 attaaattta gagatgatgt ttttttcaat aacttcaaat tgagattata ggacaagttc
    12781 atattaaatt tctcacttat atatgagttt aactgactta gtattgatag catcatttgc
    12841 attaatatat agacaattaa tactgaaaaa atgttacttc ctttttttaa aacagcattg
    12901 attaattctt gatagataaa taagcttgct aaaggaatta ttgattgtaa tatgtttaaa
    12961 attattagat agctagcata ttttctttct attcgaaaaa ttaatcttat tgttttagga
    13021 attgtcaaaa ttgtttgaaa aaaatttttt agtgtaaatt tatccatgat tgtgcccatt
    13081 tctaaattct tcactgatta tcaatccgcg aattatagca taaatcttag tctcattttc
    13141 tctctttata ccaaataagc gattattgtg tacatgaatg atactatcat aaatgatata
    13201 tgtatagtca tctgataatt gaatacaact gtctgataat ttcttaagtc tttgacatag
    13261 tttagatagt tctggaagaa gatttattaa atatcccttt attaagtaca aatcaattaa
    13321 tgcagtattc ctatttttat ctctattttg gctgtctaaa tgctctggac aagcaaattc
    13381 taaaaattgt attatttctt tattgttatc tttaaaaaat gatttgagat aaaagtagtt
    13441 aaatattatt gctaaatcat ctagggttaa atctaatctt ttctgccgaa ttaaacttaa
    13501 tgaattgatg actatttcag tatctagaca aaaaatttct tctaccaaag gaattctttc
    13561 tagtccccca tacctttcga tttctctgtc atacgttgaa atatctatat ttgatattaa
    13621 cttgttttgt atgcagagtt gaaaaatttc ttgaattttt tcaaaacttt tatataaatt
    13681 ctgcgttctt atccttagtc ggatatgaaa ttttggatca gtatatctga tatagaagct
    13741 catcccatca tctaaattta ctaacttcaa aatttgaggc attatatccg aaagaaattc
    13801 ctcttgccta tctgccgaca tatacaattt aaagtagagc cattcatcaa atggtatttt
    13861 ctgtctaaca tttgtcggaa taacctctgg taatatttct tttatgtacc taggttcctt
    13921 aatttcatcc ttagcaaata ctggaacaac tatatcagaa atatgagttg tagattcctt
    13981 ctctacaagg tgtgaatcaa aaatacactc tgatagacat aattcttcat ttttattact
    14041 actttttctt acaatatctt caaaaagttg attatctagt ggattattac ggttaattaa
    14101 tattcgatta tcactgttat caacatacaa ttttgtcgga agattgtttt caagaataat
    14161 ctgatgaata tccttcgaca acatccttcc actaagcctc caacgttcag gagcaacaat
    14221 aatgtcctta aatactattc taggaatatg agaaaatttg aaaaggcaac acttttctga
    14281 acaattttta taaagtgctt tttaagcgat aattcgtttg gtcatgggcg tttggtagtt
    14341 aagactacca tgaatgcgat gatagttcca ccagtgaaca taatctttcg ttttgagggc
    14401 taattcttct aacgactgaa aggtttcttg gttgataaac tccagtttga aggaacgata
    14461 ggtactttca gcgacggcat tatcataggg acaaccagct tgactgaggg aacgggtgat
    14521 tccaaaagct tcaagcatct catcaatcag ctgattgtca aactccttgc cacgatcaga
    14581 atggaacaac ttgaccttgg ttagtgcata agggatgctt tgaatggctt gtttaacgag
    14641 ctccgcagtc ttgtgccagc caacggacaa tcctatgatt tcacgattaa agaggtcaat
    14701 gatgagacaa acgtaagccc agcgcctatc cacacggacg taagtcaagt cggtcaccag
    14761 ggcttccagt ggtctttctt gatcgaattg cctgtctagg cggtttggaa taggagcttc
    14821 gttcttccct ttagaatgcg gtttgaaggc tgctttttga taaacggata ccaagtttag
    14881 gcgcttcatg atgcgacgaa tccgacggcg agagagtatg atgccgtcct tttctaagca
    14941 tttcttgatt tttctagccc catatctgga cttgctctca aggaaaatat aggtaatttt
    15001 atcctcgaga tcagcctctg acacaggatt tacagcttgg tagtagtaac ttgagcgcgg
    15061 gatgttcagc caacgacaca tagctgaaat gctgtattta tccttgtttg cagtgattac
    15121 ttgtcttttc gtgccataat cactgccgct tgctttagga tgtctaattg catttcgagt
    15181 tctttattgc gttttttgag ttgaatcagt tcccgttgtt catctgtcat attatcaaca
    15241 gacttgaagg aacccgttag tttggcttgt ctgacccact tatcgaaggt tgagggcgtt
    15301 aactcatatt ctttgataag ctcacttcgt ttcattccag cattgtggag gtcaacaatt
    15361 tgttgtttaa agtcatcggt gaagtggcga cgtatttttc tagacatatc tgttctcctg
    15421 ttttctttag tgtagaacac tttataaatt ctgtctagtt tagtgtaacc gattcaattt
    15481 ttgataaacc atctcccaag ggaatattcc gaaatgatct tcttgagcta tctcacataa
    15541 aaaccgtaat tcattgctaa acatcatttg gttatacata tttgtactat aaaattttaa
    15601 gagttcctta gttttgaaat ttctagcata aaaactattc ttagaatcaa taccaatata
    15661 tatatcagat aaaatttgac ttctcttatc catattcgta aaaagtgata atactttttc
    15721 tctgacattt gttgtgcgca taacattagc atgacgaaga ttctctggta aaaatgttat
    15781 ttcacaagag ttataccctg atacgtgatt attgttttca acaatttgag tgatagtttg
    15841 atgataatgt tccaatttac ctgatagaat agaaaacctg cctgagctag ctcctaaatt
    15901 cttagaacat cctgtattag ttaagcttag tacgctttta ccatctactt tattaacata
    15961 aaagaacaac tcaaatccta gattgatttt atctttgtct tgattaaaaa aatcttcttc
    16021 attataaagt tgaatatttc cacctgtttc taaggctttt tcaaaattat tgagatattc
    16081 taattcttct ttttcactaa aatatacagt agaaggcgaa gattcccaga aatcattttt
    16141 ggggtgctga tatccatatg gagaaccaat tcctaaatta gaatcaaaca actccatcaa
    16201 ctgaacttct ctatttactc cgtacttatc taaaaatttt tctttataat catctaaata
    16261 agtacgcttt acatgatctg aattacttac tagaaactca gcaaattcta ctatctgagt
    16321 tttattttca ttacctaatt ggatttgacc atcattataa agatcaattt gaagaaaatt
    16381 aggggtttca actaacgatg acattaactt gtagatttct ttaagctttt caatcccatc
    16441 cccaatttcc aattcagaat attcaacaat taagttgcta attgctatta gtttaaaata
    16501 ataaagattt tgcttatcga tttctttgac tttagaaatg aattcttcaa acttaaaatt
    16561 cattattaat tctgaattaa tatttgaaat tagaaaatga ctatcaatca aactcatgat
    16621 atatgatgtt gcaatatctc gatactcttc accataggat tcaacaagtt tttctataat
    16681 acagttaaaa tatacatatt tatcacaaca aagctcatca ataagttgat aaactttagt
    16741 gaactttatg ttgacttctt caattttagt atcatttata gaaaacaatt gaacaactct
    16801 atctccaaat tgatagttgg ctggatttat tttataggct aattctcgag aatattcctt
    16861 ctcaatctta aaaactagac gtattaacca ctctgaatcc aagagtactt tttttaatgt
    16921 ttttccattc aagtttaatt tctctgtaga agaaaatgaa cctattgaag tttcactaaa
    16981 taaaccaaat ggtgttgagc gctccttact acgcttataa tatttatata cagattctga
    17041 taattggttg atttttttcc ttttcattga atcaccacta taatattttt gaagcgattc
    17101 atataaactc ctgctggcta caaatagttg ctcctggaat atcttattct ctcttatagt
    17161 ttctaaaaat gaattataat cacattccaa caattcatgt attccaatga ttgcattacg
    17221 aaccaaaaaa ttatttgtag tatatttatg ttccattagc agctccaact tctaaattat
    17281 ttttataaat cttcaaatat tattttggaa atttataaaa ataaaggtag tagactacta
    17341 tccactacct ttattttagc aatagacata ttcgtctaaa gagtaatatc ctaaacaaat
    17401 attctaatat ttagagggac cttactcgaa aagatataga gtccctttct ttcttagtca
    17461 agatttgcaa aaagatagtt actaaacaaa taaattttat ccaaaatggc aaccacaagt
    17521 tgcagttttg attgcacagg tcatcaaaat acccgtctta catccaggag tacataatga
    17581 tttactagtt acccgaggtg aagctcctga gttgttttcc tttgagattg tgacaagatc
    17641 caaattaaaa tcttcattgt tcataataaa attcctccaa ttattttttc tttgttcgaa
    17701 caaatatatt gtaagatacc tagttcagaa tttgttcata attatagaga atgaacaaat
    17761 tttttattta gaatgcatga aatatttata ctgatactct ggacaattaa ataaaaagat
    17821 agttgaccaa tgaaactgct gaaaaagtct gatattttta aaatatcatg aacaatactg
    17881 tcttgaaaag ataataaaat agacataaaa agcggatgat ctgcaatctt tagatttcaa
    17941 aatatgctgt cattcgcttt ttatctattg aattttgttg tattctactc ttttagtgac
    18001 ctctaaccaa tttacctctt tttacatatt ttttgaattt caacattatt cataacagct
    18061 aaattacaaa aatacgataa tatgataaaa ccaattaagt atactagaat cataaaaatt
    18121 tcatttttcc caatttctag gatcatatta acaggtaaaa cgataggcaa ccagaagtta
    18181 tttaaaaata ctttattggt tgcaaatata ataaacagac attcgataaa agaaattact
    18241 agattccctc cctttcccat gataagacta agtaacatat ggaaatggtt aagtaagact
    18301 aataataacc aagtaatcac accaacatac gcaaagtaag agagtctatt aaattcaact
    18361 cctaccacta tccaaactgg aactcccaat aaaaccataa gtaagtctgt cgaaataagc
    18421 tttattcccc aaataattcc actatttttt tcgcttttaa tattttgaaa gaaatttgct
    18481 ttttcctctt gttcatgaag aaaaatagag aaaattgatg ctaatataca atatcctaac
    18541 ataggtaaaa aaatgatatt ttcaattaca actgaattat ttgtaaactg taaataaaga
    18601 ggaattgtga ataattgaat aattgataaa attaaaataa gatttaaagt aagagagcct
    18661 ttcaacttta gcaactcact ttttagaatt ttgttcatta gttatcctcc acttcaacaa
    18721 actaaggaaa ctcacaaaaa ctaagattga aagagatact gatattaaaa ttgtcgatat
    18781 ttcaactcca cttaatgctg cctctaaatc acctgagggt tttaaatgta aaagagcata
    18841 agcaatttta tagtgataag tataaggaaa tatgaaccaa accgatgtct gagctattag
    18901 aggagcaact aataagcaaa taagagaatt tgtagccaac aacaagtagg gatttatcca
    18961 ctttgctaga aaatataata gtggtaatac ccaagcagaa gaaacaccaa taagtaataa
    19021 acaaatcaaa tctttaccaa tgtctactga tatcacacct gaaaaaagaa atgagatgcc
    19081 ataaaatatt atcgtaaaaa taaaggttga aatcaaaaca tccttgaact tcaacagtat
    19141 cttcgctaaa taaatagtaa acgtatatct acccaagcta atattttgaa acgcacctgc
    19201 attctcctcc gcgctataat cagctaaaaa caataaccca aggagagtga aaaggaatcc
    19261 tccctcccac caataaattg aaaaactttc taaattgaga ggtcctgcta gtatgaaagc
    19321 tataaaaatt gctagcaaag gaataaggat tagtaatttt ttatcagaac tagatttttg
    19381 cttcagccac tcagatttaa aaatattagt catttccatc acctccatgg acaattctaa
    19441 agaatagttt ttctaaatca tttgaattct tattaatatc atcgtaaaaa atcttgccct
    19501 gattcagtat aacgatttga tccgcaattt tgctgacttc acttagttga tggctggaca
    19561 agaggactgt cattccagat ttttttagat ccctaattaa atttagcaat tcttttatcc
    19621 catctggatc tagaccatta gttggctcat ctaaaattaa taaatcagga ttggtaataa
    19681 ttgccattcc taaaccaagt cgttgcttca ttcctaatga aaagtgccct gccttctttt
    19741 ttccagtatc agataaacca accaactgaa gtacctcata aattctttca tctggaatat
    19801 catgtagcaa tgctcgtgtt tttaaattgt caaatgcaga aagattcaaa tagatagcag
    19861 gagattctat caacgctcca atatcaaatc tattttcttc tacaatatcc ttatgctttc
    19921 cattgaaaat gacttctcca ctatcagctc tttctaaccc aaaaagaatt ttcataatgg
    19981 tggatttccc agccccattt actcccagaa gaccacaaat agtaccttct tcaattttaa
    20041 atgaaacgtc ttttaaaacc tctttgtctt tatagctttt tcttagattt tgaatgataa
    20101 cttccatttt ttctgcctcc atttctttta ttataataca aaagaaattt cagtatttgt
    20161 tcagaaaaaa attgagcaaa aagtcgatat ctctttgatt ttttcaaatt ttcgaaataa
    20221 aaaatcgcat aaaatcaacg tttttaaatg aaagatttca tgcggttttg tttatattag
    20281 gctttttgac cagcccctaa aattttttaa ttaataaagt gacctgtgca ccaccatttt
    20341 gtggatttga gagtattaat tgaccttgat gtctcatagc tatcttttga gcaaatgaaa
    20401 gtcctattcc gtaatgctta tcatttcttc ctttattctc tgtgtaaaaa agttttcctc
    20461 catctttaag agactcttct gtaaatggta aaccattatt ccaaatctca aaactgataa
    20521 agttggaact ttcagatata gtcagtacca ccttgccctc ttctgaacaa aatctagtcg
    20581 cattagataa gatatttatc aaagctcgat ctaagttgag acgatttcct ttaatcactc
    20641 tggtatggga ttcattaact atttgaaaat taattttttt tgaagacata atatctcgac
    20701 attctaatga taattcatca agaaattttg ataattcaat atcttcctga taattcttat
    20761 cctcaattag caatcttgag taattaacca ttgaattaaa atacttttca aatataccaa
    20821 cactatgatt cattgaggac ataaaatcta attgtttttc atctagatta gtcatctcaa
    20881 gcaactcgat attccccttt aaaacagtta atggtgtttt aatatcatgt gctaatgcag
    20941 caacttgaaa tgacaaatct tctttatctt ttttctccat ttctaataac tttgtcaact
    21001 cttcgtcttt ttgataaagc gtcaataaaa tgttattaca ttctaagatt gcagtttctt
    21061 tacgtccaat atccattcct ggtattccca tattcagaga tattttttca attagacgaa
    21121 aattttttgt aaattctctt aagagcctaa taacagagat agagatgagt aataattcta
    21181 gcactataaa aaacaaataa gagactaaat tataggaaat atgtcgaaag tttcgattta
    21241 caaattcggg cattgttggt cttctaataa ccaaaataaa atctgagttt tcatattttg
    21301 taaacaatat agaaccctcg ctaaccgaac ttccagtatc aaaaacttct ttataatgtt
    21361 gtaaatcctg tttttgataa tttccagaga ccaattcgcc attatcgcta tcaaacaata
    21421 cataatcaaa gacagaataa tccatttgat tcttaatacc gttagcagat ttactatcac
    21481 taattgaaat atgatagtct gttccatatg tgttcaactg acctgtaaaa ataagaacgt
    21541 agctcaatac aagcaacata ataacatttg caactgtacc aatcactatt tcaagaactg
    21601 tccttaaaat ccgcttatta attgaatacc ttttcatcat tccacttata tcccatcccc
    21661 cttattgttt taatgggatt aattccatag ggaccaaact tgactctaat ttgataaatg
    21721 tattccgaaa ttgaacgaaa taatgcatct gcttcatcac catagacaca ttcatagatt
    21781 tcttctcttg tataaacctt atttgtctta ctagataata gctctaaaat atcatattcc
    21841 cttttagtaa gagaaatagc ttcaccatta acacacacga gtttttcttg aaggtaaaat
    21901 gttagtggaa ataattctcg aataacagat tcattagatt cagcatttct ataacgttct
    21961 tctcgtttta aatgcgctgc aaccttagca actagttgat taacactaaa tggctttgtg
    22021 atataatcgt caccaccgag atttaagcca gatacaatat catcttcaga atcttttgca
    22081 ctgacaaaaa taatcggaga ggatactgat ttacgaatct gtttacagat ttgcagacca
    22141 tcaacatttg gcatcataac atcaagcaat attaaatcaa atccatcaaa atcacttatt
    22201 tttataggaa gcctaacttc ttgataagtc gtcacattat agtttttcat ttctaaaatt
    22261 gttcgcatca attttacaat ttcaaaatca tcatcaacta ccaaaatctt atacatacta
    22321 ggtacctctt ttatctcata ctactatttt acactattat tgcacaaaat ttgtaatatt
    22381 tagtagccta atttgtccat tgtttccatt attactaaga aaacaattat catataaaat
    22441 tcgaatagct tcatctggtt ggtccttcaa attatacttt tctataatca atcctaaagc
    22501 tgcagagact ttaggagtcg aaattgaagt cccatatgca tatgtatact ttccttcaag
    22561 cgttggaaca agaatccatt ctttttcata taatttatca gctacccatt tatcatatcc
    22621 tactttagaa agcgcttgac ttccacctcc tgttgcatag atatcaatgt cgccattccc
    22681 ttgatttgag aaactagata caagatcatt atcatctact gaaccaactg taacaacatt
    22741 gtctaattca gccggaatat cttgtacagt tccatcaact tgactataat cttttcctct
    22801 taaactacca agatagtttt ttaattcatc ttgattctgt aaatccatcc cttcatcacc
    22861 tactgaagca acgacaacgg aaccttgatt atgagcataa ttaattgccc gttgatagat
    22921 attgatcaaa gctgtatcat catcttcatc agtggaatct cttaacaaat attctcctaa
    22981 actaaggtta ataacatcaa catcatcttt tgctgcttga atgagcgctt tgagaatcca
    23041 ttggtcttga gcattccctt catcaaaaac acgatacatt cgtattttca tgtcaggtgc
    23101 tatccctaaa tattctccac ttgatgaaat ttgtcccaca acagaggtcc catggccaat
    23161 tttatctaca acattttggt tatcaactat tcctgtttcc aaatctgatg tgaaattttg
    23221 tactgaaata atgtgtgaat aaatatctgg attatcatat gtaataccag aatctattac
    23281 accaattgtt gctttaccag aagacttatg ttgaaattta cttccagtac taatactctt
    23341 ttgcatatcc cactgatttc cccaaaaatc taaattagta tttgtataaa ccttgtcccc
    23401 atacaaataa gtaatattag gctttacagt catagtatta tctataacta tgtcatcaat
    23461 ataattagag ttttcttttt ttattgtatc ttcacttttt tcggtagaaa tagttaaaaa
    23521 atttatttca ggtattttat cagtaacttt aattccttga ctttgtaaaa catcttctac
    23581 atcctcaata gatttatttt cactaactaa aacattataa ctaatttcct tattttcatt
    23641 agcacttact cctgatgaca cagaaccgct agctaatata acaataaaca atgatataaa
    23701 aacattcgac aataagccta tctttttcat aatatcatct ccttagtttt ttattccttt
    23761 ttatcaattt tatttcagaa tttcttcaga gtactcaata tttggtatca ataaatccga
    23821 aaaatgctat tctttcacat ttttttcact gtgttcaaat tttagttcat ccttgcttga
    23881 gtctatttca tttaaaattt tgacaaactt ttccaacctc cttattaaat actcataatc
    23941 atctattgac ttatctaact taatttgata gatttcgatt tctttctcaa cttgttccag
    24001 ttttatagcc gcagttagat tcatcttggc atagtcatat ttggccaagc ggcggttctc
    24061 tatatcgtta ttgtccaggt taagcaagac ttccgcaacc ttgttgagat gatctatgtg
    24121 ttcctgaatc tctgtaatgg tcaaatctaa ttgagcaata tccttaataa tctcgtcttt
    24181 aatatcttga taagacttat tctccgtacc caactcaata agaagattaa tctcttcaat
    24241 ctttttctta agtgtgtcaa tggtcggtct ttttctttta gagatagtct ggctatcatt
    24301 ggttaactga cgaatgagtt cacgccctcg catatagcga ttgagttcgg acgcctcctt
    24361 attgtaaatg aaaaattgtg cggtctcacg gataaaggca tggtagtgtt taccactctc
    24421 tgtctcttta atatctaaat gacggtttgg gataaagacc aagccatctt ttttaacgcc
    24481 gtagttcatt ctgataaaga gaccatcttt gactaactta tcaatctgat ggtcagctaa
    24541 gacgacatca aactcttgaa cctggtctct tttctcctta aatgcctgat aagcctcttg
    24601 caagtcttca taagctagct tttccttatc ttgttcctca caatatccct caaagtcgga
    24661 aataagttgc gactggtcaa tatcaggaac ttctccacgt ttctcaaagt aagtttcgaa
    24721 aaattgaaca tcgtagagat ttttggaact gactttttga ttattgactg taatgctctg
    24781 actatttttt gttagagtaa acgccacatt cttttgtttt agagacatag caaggttgag
    24841 ttctcttgca aactccaaaa gttgtgaaag gtcacgaact ctgggtaaga gaaaatctaa
    24901 acattgctca atcgctcgct tggcaaagtg ctctcgaaag tattcctcgg tatagggttg
    24961 acgtttatct agttgcttgc ctcgaataac tcgcttcatg ggcatatccg tcatcaaaaa
    25021 acgagcgtat tttcttgaaa aatcaatctg aacattcaat gcttctgcct tggataaaaa
    25081 gtcgtcaaaa tccttactat tctccatcag aaaataaaga cgttgcttca attcaaattt
    25141 gtgattactt ttgcgatagg tcacaaactt ctcatgagaa taacggttcg gtgtgataat
    25201 tttggcacct gcttctttgg aaagacggtc agaaatcatc cgtaaatttc tctcctgagc
    25261 ataatcccat ttgagtttct tatgagaatt gaggtcaaca gaattgatga ggatatggtt
    25321 atgaacatgc aacctatccg tatgggttgt cacaataaag cgaaagtttc cgccagtcaa
    25381 ctcctttatc gtctcataac caatacgatt gatttcttca ggtgtaagat tatcctcagg
    25441 tgagaatgac tggataagat gatgagcatg aattttattt tgcttgattt gttgccggtc
    25501 atttctcgaa tcataaagcc tatcattatt gacaaagttt gcctgataca tctcaactat
    25561 ttcttcataa ttagggaagt cgaggtaatt gctcattcca aaatctgaaa ccaatttgag
    25621 ttggtcagtc ttagctggat ttagaatata cttgataaga cttttacggt atttgttgcc
    25681 atgaaccgca aaatgtttag tgactaccat aaaattccct caacttttga cacttgacat
    25741 agaagtcctt atcaacttcc gcaatcagct gacctatgcc cgttttcaaa ttatctcgct
    25801 gctctactgt cagaagtttt gtctgattga ctgttttagc tatctggtta atgttattgc
    25861 caattcgacg taattcaaaa accaagtctt ggtagttact ggtatcaatt gttaaaaagg
    25921 tcatatttgg attaagcaaa acctttctgg cataagcaga aaaattttga caagaacttt
    25981 ggctaatatg attgttcagg ttcgcaagtt cctggtctgt taaaaagact tttttgagat
    26041 tggttcgata acgattttcc atatctaacc tcccatatac ttatctcgaa attctgaact
    26101 gagtggtact gccttctcta cttctgtcat cagttcttga acacaagtca atataattct
    26161 taagtgttct gacgtgacct gatggcctcg ttccgctaga gttgctacct gtaaaatatc
    26221 tctactgatt tgttctattt tttgagattg ccacagaata aaccaatctc tgatgtcatc
    26281 cttgttattg acaatgtcca atagtttttg tctaacaaag ggagaaaact gctccgcatt
    26341 ctcctttctc atcagtagtt gaatctgctc aaattcctca agcgtcaagt tgatttcctt
    26401 acgaattgtc cgataacttt ctgtcatgat gatacactcc ttctcacatt tccctctagc
    26461 gggttagcac cgataccata tctgatacgg gggctcccta aaagcctcaa atcttccctt
    26521 ttcggctttt gcgagctcag atattgtgtc cacaatatcc caaaaatctt atcgccagcc
    26581 gaccaaaacc tttgagtttt gatagccgat gataagataa cttggtggct tcgcccccaa
    26641 acccccatta gaaaatcgag acttgatttt cttaggtatg attttaggat aatagagatg
    26701 atttggaaaa gatatcacat catcaaaaag aaggtaaaaa agagagctaa aagctctcgg
    26761 taaactatct taaatattta gcaaaatatt ctttaaaaat atatgggttc taaactcttt
    26821 tgtgaaaaac ctttagagag tttaatacat tcttttacaa taccttttcc tggtcggaga
    26881 taaaatgctc taataccttg aagtaactta ccagcatgtg aatgatactc ttgatttgtc
    26941 atctcatcta aacgaatata tctactgcta gtgcgaattt attaccataa agaatatcat
    27001 cctcatatct atgtctagtc atataatctt taatatcata gagcatggaa ttcatatttc
    27061 tataatttgg tgcccctact aatgctctac tcgctctatt tataccatca acatagctat
    27121 atgtatcgtt tagagaatta aaatccaaaa tctcttcgaa tcaaaatact tatattccct
    27181 atctagttgt gattttagta cccgtaaaat agataatgca gtaatcttat cattattttt
    27241 aattgcaata taggct
//
