LOCUS       NZ_JAHXMW010000013     20261 bp    DNA     linear   CON 13-MAY-2024
DEFINITION  Paenibacillus silvae strain EYE_43 Seq_13, whole genome shotgun
            sequence.
ACCESSION   NZ_JAHXMW010000013
VERSION     NZ_JAHXMW010000013.1
KEYWORDS    WGS; RefSeq.
SOURCE      Paenibacillus silvae
  ORGANISM  Paenibacillus silvae
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 179295)
  AUTHORS   Pu,J.
  TITLE     Study on the microbiota of ocular surface in healthy people
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 179295)
  AUTHORS   Pu,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-JUN-2021) New Pathogen, China CDC, 155 Changbai Road
            Changping District, Beijing 102206, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023149095.1-RS_2024_05_13
            Annotation Date                   :: 05/13/2024 05:30:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,071
            CDSs (total)                      :: 5,941
            Genes (coding)                    :: 5,912
            CDSs (with protein)               :: 5,912
            Genes (RNA)                       :: 130
            rRNAs                             :: 9, 12, 12 (5S, 16S, 23S)
            complete rRNAs                    :: 7 (5S)
            partial rRNAs                     :: 2, 12, 12 (5S, 16S, 23S)
            tRNAs                             :: 93
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 29
            CDSs (without protein)            :: 29
            Pseudo Genes (ambiguous residues) :: 0 of 29
            Pseudo Genes (frameshifted)       :: 8 of 29
            Pseudo Genes (incomplete)         :: 20 of 29
            Pseudo Genes (internal stop)      :: 3 of 29
            Pseudo Genes (multiple problems)  :: 2 of 29
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:11:56
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 56873
            Orig. end                         :: 77134
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAHXMW010000013.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20261
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="proteusin"
                     /region_number="1"
                     /rules="(PoyD or TIGR03793)"
                     /tool="antismash"
     cand_cluster    1..20261
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PoyD or TIGR03793)"
                     /kind="single"
                     /product="proteusin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20261
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10261](-)"
                     /cutoff="20000"
                     /detection_rule="(PoyD or TIGR03793)"
                     /neighbourhood="10000"
                     /product="proteusin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10261)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PoyD or TIGR03793)"
                     /neighbourhood="10000"
                     /product="proteusin"
                     /protocluster_number="1"
     misc_feature    240..254
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 23.39"
                     /tool="antismash"
     misc_feature    complement(241..256)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 21.65"
                     /tool="antismash"
     gene            complement(297..1271)
                     /locus_tag="KZX51_RS24600"
                     /old_locus_tag="KZX51_24525"
     CDS             complement(297..1271)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017690249.1"
                     /locus_tag="KZX51_RS24600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_24525"
                     /product="ring-cleaving dioxygenase"
                     /protein_id="WP_248064364.1"
                     /transl_table=11
                     /translation="MLIKGLHHVSALTAHADQNYRFYTDVMGLRLIKKTVNQDDVSVYH
                     LFYGDEKGNPGTELTFFEIPMAGRTREGVNSISATSLRVPNDAALQYWVQRFDEYEVPH
                     GEIVERGGRATLAFTDFEGMRLILVSDEHNSGVAGGKPWDQSPVPAEYGIVGLGPIHLT
                     VRDASLTAPVLTDLLGFRAKGSYPAFTPGQPDVLVFESGAGGSGSEVHLEERTDLEQER
                     PGRGSVHHVAFRVDNEEELRQWVDRVHQFQFPSSGFVDRFYFRSLYFREANGILFELAT
                     DGPGFDTDEDFATLGESLALPPFLEGRRAEIEANLKPLDTMLR"
     misc_feature    1321..1337
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 25.03"
                     /tool="antismash"
     misc_feature    complement(1378..1391)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 22.39"
                     /tool="antismash"
     gene            1584..2363
                     /locus_tag="KZX51_RS24605"
                     /old_locus_tag="KZX51_24530"
     CDS             1584..2363
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017690248.1"
                     /locus_tag="KZX51_RS24605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_24530"
                     /product="TIGR02206 family membrane protein"
                     /protein_id="WP_248064365.1"
                     /transl_table=11
                     /translation="MAYAPWLDPYDAPPFIALSTSHMISMTIIVLLVLLLFLFRHSLRR
                     LSERSSRLLRIGLASMMIGSEILLQLWYVYGGIWSLQTSLPLELCSLTLLLSALLLLTR
                     TRWLYSAVLFAGIAGALMAIVTPNLGYAYAHFRFIQFFTAHAMIILALLYMTWVEQFRP
                     GWRSVAGSMIFVNIAALVVYAVDVLLGANYMFLRHKPNTPSVLDMLGPYPVYILGEEVL
                     ALVLFTLLYIVLFAIPDRVNQHHNRKKTKTHQIQSKL"
     gene            complement(2468..3262)
                     /locus_tag="KZX51_RS24610"
                     /old_locus_tag="KZX51_24535"
     CDS             complement(2468..3262)
                     /NRPS_PKS="Domain: PKS_KR (9-172). E-value: 2.5e-15. Score:
                     48.8. Matches aSDomain:
                     nrpspksdomains_KZX51_RS24610_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013915458.1"
                     /locus_tag="KZX51_RS24610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_24535"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_248064366.1"
                     /sec_met_domain="adh_short (E-value: 1.7e-36, bitscore:
                     119.1, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 7.2e-34, bitscore:
                     111.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEQRLQGKVAIVTGGGSGIGQASAIRFAEHGAKVYMLDRTPENA
                     EKTKHRIENNGGTAYVIECDISKPEDVQKAIQQAAAEAGKLDIVFANAGINGAMAPIET
                     MSIEDWDQTMEINMRGTFATVKYAIPHLKERGGSIIITSSINGNRVFSGIGFSAYASSK
                     AGQTAFTKMAALELARYKIRVNAVCPGAIDTNIDDNTYPSDDLKDVQIPVEFPEGHEHP
                     LKGEPGTSEQVANLVLFLASDEASHVTGTRIYVDGAESLLRG"
     aSDomain        complement(2747..3235)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KZX51_RS24610_PKS_KR.1"
                     /evalue="2.50E-15"
                     /label="KZX51_RS24610_PKS_KR.1"
                     /locus_tag="KZX51_RS24610"
                     /protein_end="172"
                     /protein_start="9"
                     /score="48.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAIVTGGGSGIGQASAIRFAEHGAKVYMLDRTPENAEKTKHRIEN
                     NGGTAYVIECDISKPEDVQKAIQQAAAEAGKLDIVFANAGINGAMAPIETMSIEDWDQT
                     MEINMRGTFATVKYAIPHLKERGGSIIITSSINGNRVFSGIGFSAYASSKAGQTAFTKM
                     "
     CDS_motif       complement(3161..3229)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_KZX51_RS24610_0001"
                     /evalue="1.20E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="KZX51_RS24610"
                     /protein_end="34"
                     /protein_start="11"
                     /score="18.0"
                     /tool="antismash"
                     /translation="IVTGGGSGIGQASAIRFAEHGAK"
     gene            complement(3424..3690)
                     /locus_tag="KZX51_RS24615"
                     /old_locus_tag="KZX51_24540"
     CDS             complement(3424..3690)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015736189.1"
                     /locus_tag="KZX51_RS24615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_24540"
                     /product="YqkE family protein"
                     /protein_id="WP_145403546.1"
                     /transl_table=11
                     /translation="MAKSKRRAPAPKARAQAQDQPTTLKDLLSSDVLEKLKAQADEAKA
                     AEAARKEQERLQAEEARKAEQKRRDNDFEYLLNNSSMDWKKHK"
     misc_feature    4047..4058
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.11"
                     /tool="antismash"
     gene            complement(4127..4789)
                     /locus_tag="KZX51_RS24620"
                     /old_locus_tag="KZX51_24545"
     CDS             complement(4127..4789)
                     /EC_number="5.2.1.8"
                     /GO_function="GO:0003755 - peptidyl-prolyl cis-trans
                     isomerase activity [Evidence IEA]"
                     /GO_process="GO:0000413 - protein peptidyl-prolyl
                     isomerization [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017690243.1"
                     /locus_tag="KZX51_RS24620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_24545"
                     /product="peptidylprolyl isomerase"
                     /protein_id="WP_145403545.1"
                     /transl_table=11
                     /translation="MSLRWKKATAVSLVLAMLLIVMSGCGRPANNAYQTPVPAVPEGPD
                     PVATIEMQDGQKIVIELYPKIAPNTVYNFISLANKGFYDGLIFHRVIPGFMIQGGDPNG
                     NGSGGPGYAIKGEFTSNGHKNHLKHTRGVISMARKSENLDSAGSQFFIMLADADHLDNS
                     YATFGKVTEGMDVVDGIAAQQIGEGDKPVTDQIMKKVTVDTHGIEYPEPVKITTDTK"
     gene            5009..6232
                     /locus_tag="KZX51_RS24625"
                     /old_locus_tag="KZX51_24550"
     CDS             5009..6232
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007783547.1"
                     /locus_tag="KZX51_RS24625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_24550"
                     /product="MFS transporter"
                     /protein_id="WP_145403544.1"
                     /transl_table=11
                     /translation="MNFSWKRNLVILWIGVFFCSTAYSISIPFLPLFLSSDLGVRDHLE
                     FWSGLAFGITFLASALVSPFWGSLADKYGRKPMLIRSGYSLAVLYLINFFVQDPYSLIV
                     VRLFQGLLAGFVPAAIALVGTNTPEEKTGYALGIMSTAGATGGIIGPLLGGLVSHYYGN
                     RSAFLFSAIVVLVSAVIATFWVKEENFNRNKARSHVMDDIREARANRVFITVLVMMGIC
                     TFSVMILEPLLTVYVMEMGIQPDRASLSSGIIFSAVGVATVIMAPRWGKLGARIGFGKV
                     MVIGLVGGAVGNLLQFFTTGYVAFGILRFVYGLFFAAVFPAINAMIVQVTEPSFRGRAF
                     SLNQSAAQMGTMAGPIIGGILGGWLPIRWIFIINGAALLATAIAVKWTRLEHKLPGAGS
                     TVEKQSRL"
     gene            complement(6490..6687)
                     /locus_tag="KZX51_RS24630"
                     /old_locus_tag="KZX51_24555"
     CDS             complement(6490..6687)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KZX51_RS24630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KZX51_24555"
                     /product="hypothetical protein"
                     /protein_id="WP_145403543.1"
                     /transl_table=11
                     /translation="MSNNAEERQVQKPDNLVTERDIDPDFGLFTEDSFPGALEDEDQRQ
                     AIEHAIPKEQSSDKPASDSD"
     misc_feature    6657..6671
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.71"
                     /tool="antismash"
     misc_feature    6704..6719
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 24.01"
                     /tool="antismash"
     gene            complement(6920..7111)
                     /locus_tag="KZX51_RS24635"
                     /old_locus_tag="KZX51_24560"
     CDS             complement(6920..7111)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007429105.1"
                     /locus_tag="KZX51_RS24635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_24560"
                     /product="hypothetical protein"
                     /protein_id="WP_308423473.1"
                     /transl_table=11
                     /translation="MDEQFLESRLAEPPLESVPDADLLQPGSPVDPAAPDPDALHGTDL
                     LNGAGADAKPERNILPPR"
     gene            complement(7259..7423)
                     /locus_tag="KZX51_RS24640"
                     /old_locus_tag="KZX51_24565"
     CDS             complement(7259..7423)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KZX51_RS24640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KZX51_24565"
                     /product="hypothetical protein"
                     /protein_id="WP_167433920.1"
                     /transl_table=11
                     /translation="MMNEPHRTVEVEHKDVQYKSDSSKVASTFIKYAAYIIIFFGFLYF
                     LVKYVFPKF"
     gene            7568..7849
                     /locus_tag="KZX51_RS24645"
                     /old_locus_tag="KZX51_24570"
     CDS             7568..7849
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017690238.1"
                     /locus_tag="KZX51_RS24645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_24570"
                     /product="hypothetical protein"
                     /protein_id="WP_145403541.1"
                     /transl_table=11
                     /translation="MDWFTLGNMITRIRIGQKASTPGFSRTVIRRPDGLFWVGGIWAGQ
                     VVQLRDFLFSDIWTIYDDDETEQWLEFRMKVEQKEREMIVNQFEDLRE"
     misc_feature    7908..7924
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 22.79"
                     /tool="antismash"
     gene            8001..9911
                     /locus_tag="KZX51_RS24650"
                     /old_locus_tag="KZX51_24575"
     CDS             8001..9911
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017690237.1"
                     /locus_tag="KZX51_RS24650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_24575"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_145403540.1"
                     /transl_table=11
                     /translation="MRNVPKAIIILWMTIWIILLPNGLVFAAAEEVRQPEAITGWEVKW
                     GDANDQGFISEVMGEDEIWEKQGAGRSMVTSQNRMMQHTDSLWTRLEIPPLHDESSAIR
                     FENIKGTHIVIYLEDRKVYENYHYNYDNNAVFLPLSVENSGNTLYIWSQNENGWLGIKG
                     DVQIGPYAMLQEKYIHNGLIDVILGSTFIFTSLVMLSCTFFLGQFHKGLWMSLCVVMGS
                     IGVMVITYSQFLYTFYQVYGDLYSLLFDLAMLLGMPALCYFFEQIIGPGVYGIFTKLRK
                     IQWAYSVVAVLSLFIYVITGGQWDWLYNLFVQNVVGFVLVILLTILFVGTIAKALQRNR
                     EAILLATGFGVFSLISVLELLWYYQRNGTYHLLWWKWSMVAFVISLIAILGSRFAEKHN
                     KVLQYSKELELFNNELQRSEKMEIISELAASVAHEVRNPLQVTRGFLQLMTEQEDNKNK
                     GYVRIALEELDRASGIITDFLTFAKPEFDHIISLNISDEFDHIEGILVPMANLEGGKIT
                     TDIPPNLHIRGNSSKFKQAFINIIKNSIEALQGGQGQIDIWAYSQEGKVKVHVRDNGEG
                     MSEEALSRLGEPYFSNKIKGTGLGMMVTFRIVEAMNGQISFTSTKGVGTEAVVSFPEFV
                     E"
     gene            complement(10001..10261)
                     /locus_tag="KZX51_RS24655"
                     /old_locus_tag="KZX51_24580"
     CDS             complement(10001..10261)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     proteusin: TIGR03793"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017690236.1"
                     /locus_tag="KZX51_RS24655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_24580"
                     /product="NHLP leader peptide family RiPP precursor"
                     /protein_id="WP_248085863.1"
                     /sec_met_domain="TIGR03793 (E-value: 1.5e-20, bitscore:
                     66.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGMLVMMVSEKTLHEDIIEKAWADEKFRQQLHSNPKQALREAFG
                     ITIPDHIRVRTVEEQQNDYVLVIPPNPSKVNYDVNCGPWRN"
     gene            complement(10269..11246)
                     /locus_tag="KZX51_RS24660"
                     /old_locus_tag="KZX51_24585"
     CDS             complement(10269..11246)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KZX51_RS24660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KZX51_24585"
                     /product="hypothetical protein"
                     /protein_id="WP_248064368.1"
                     /transl_table=11
                     /translation="MMRREWLDPYTPDVEALFAAAEDKLRQYPEPLARHALEQLHQLHP
                     VRTDSGLSCIGYISPLWMHHTDGLPLDKAHLLGTACLLHMLYFLNMDDVMDEPEEDAVA
                     KLTLGNLYYVDALQLYSLLFEPSSVFWVHFRRVIQDWAVSVNGERHIDYFQLNPLLIAQ
                     KASPSQLGAIGSLLLLEQPARITSMCDALNIVLMTLQMTDDFTDMKQDAVHGNYNSYLS
                     HISAALHHDYAIHTVNDSILNHIYNSYFMDSYAEIASQFQNALTSYNLVLPQYIVLNSY
                     LYNALVQAVLDIKQRKKRLYQGGFHYWISESSSMLPEKGNADSV"
     misc_feature    complement(11293..11311)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 23.4"
                     /tool="antismash"
     misc_feature    complement(11319..11333)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.7"
                     /tool="antismash"
     gene            11459..12193
                     /locus_tag="KZX51_RS24665"
                     /old_locus_tag="KZX51_24590"
     CDS             11459..12193
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KZX51_RS24665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KZX51_24590"
                     /product="hypothetical protein"
                     /protein_id="WP_248064369.1"
                     /transl_table=11
                     /translation="MKTNWKTRVAVAVAAVIISAVPGPRVLASSTMPVEQGKAVSAESA
                     TQHKKPCIHAGHGLFMIGETAEMLGIGLRDLKQQMELGHTLAQIAKERKGLSEQQLLQK
                     LKPALSERLDQAVTEGCLTKEQAAAAKADMDVKLKKVVNTPLRELRREFAHHGKHSMIN
                     KGAIARYIGITPEQLQEQLHAGKSLAEIAQTKGISETQLVNQLKEQLTGDLQRFVRQKH
                     LEHPVPVRPGHVPGRAASTDEK"
     gene            complement(12287..13516)
                     /locus_tag="KZX51_RS24670"
                     /old_locus_tag="KZX51_24595"
     CDS             complement(12287..13516)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1088: acyltransferase 3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017690233.1"
                     /locus_tag="KZX51_RS24670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_24595"
                     /product="acyltransferase"
                     /protein_id="WP_248064371.1"
                     /transl_table=11
                     /translation="MKKPKIAEWTELRGLAFLAIVMQHNIAEYIYRTDIEQPDSVMLTM
                     IYHLTRFGTPTFVFLSGALLFYHHRHAKPNYARFIKKRFGDIYMPFIIWTLIYWLAVRM
                     FTPAFWSSGMPDLGSFVRELFLPQTGYHLWFVLMIFQFYILFPLFLTGAHAVRKRLESN
                     PHSRLTSGQRTLAIILAAAAMYVCLLKWSYYDMSGWTNLLSEPWSSLLEYRSYSWIMYW
                     FYFLLGAVCAWAVENWRGWTTKVLPWTIIVFIMMYIWLGYDVLRGSEDTMNLNISTYLK
                     PSTFIIIMAQMLMFYGLLALFRDKDLGFRRLLDWIGRYSFGGYLVHALVIYAIAYFTRP
                     LHLSGWHLLATVLSFAITVVTALGISWGLSKLPGSRFTVGLSRHRYKAKASNTLSSTQT
                     RVKRQPSHSG"
     misc_feature    complement(13591..13604)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 21.35"
                     /tool="antismash"
     gene            complement(13660..14664)
                     /locus_tag="KZX51_RS24675"
                     /old_locus_tag="KZX51_24600"
     CDS             complement(13660..14664)
                     /GO_process="GO:0070726 - cell wall assembly [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017813175.1"
                     /locus_tag="KZX51_RS24675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_24600"
                     /product="LCP family protein"
                     /protein_id="WP_145403536.1"
                     /transl_table=11
                     /translation="MLKRWLWGTVLTLVLAVTGVIIYYGYSIVHFANSISTVTSASSSN
                     DGSDKDENSNASLVQIPKWEGQERVNILLIGGDSRGDDAGRSDSVMVASIDPVSKKAHL
                     FSVLRDTYVDIPGHSKSRLNAAFSYGGAELTKQTVSNLLGIPIQHYVYTDFTGFIALVD
                     ALGGIDIDVEKDMYYTSKADKHMYDIDLKKGLQHMDGKTALQYVRFRHDATSDFTRTQR
                     QRIFMTELAKKMQSSTSLFKVPEILEAVAPYIQTDLSPAQMLKLASLGFDIRVNEMNQH
                     QIPPNKLLTNERAGSAQVLGVNVPKLQAYIQKLFEEDHSDSNEAETGQPTSNE"
     gene            15030..16733
                     /locus_tag="KZX51_RS24680"
                     /old_locus_tag="KZX51_24605"
     CDS             15030..16733
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1061: methyl-accepting
                     chemotaxis protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017427505.1"
                     /locus_tag="KZX51_RS24680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_24605"
                     /product="methyl-accepting chemotaxis protein"
                     /protein_id="WP_145403845.1"
                     /transl_table=11
                     /translation="MRFTIRGKLLAGFSIVLALLIFVSVYTLMQVSTMADQSRQVNKTW
                     MPSVSLLGIMNGDVSDVERLALAVIVEQDPSETEKLNEALNVVLAKIEDERKELLTLIK
                     GNTDAEKLYEQFSTNYDAYLQKQPSFIENGLKNDYLAASKLHTESYPLWYAANDSITQL
                     INLGNNGAKEIAAESVKLAENAFSIILGVAIVATLLALFIAFFIASMISRPLKKMTEAA
                     TAIAEGDLTGESIVLKNRDELGVLATAFNTMSGNLRSMIQSVSETSEQVAASSEELLAS
                     AEQNTRASEQITETVEELSVGTTDQIDLVKRSSQAMNEMALGSEQIAELAQSVSVSAVD
                     AANQSTEGNKIIQQAVEQMGTVRNSIASLRVLVTGLGERSAEIGTITEVINNIARQTNL
                     LALNAAIEAARAGEHGRGFAVVAGEVRKLAEESSASAQQISEIVQLIQQDTNHAVEAVK
                     VNSNETEAGIELVAAAGQAFEQISGAVNKVAGEIEEVSAGSEEMSASTNEVMSYVNQTS
                     NIAGEAAGAVHNVSAATQEQLASMEEIASSASLLSKMAEELQGQVNKFRV"
     misc_feature    16819..16834
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     gene            17080..20001
                     /locus_tag="KZX51_RS24685"
                     /old_locus_tag="KZX51_24610"
     CDS             17080..20001
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017690230.1"
                     /locus_tag="KZX51_RS24685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_24610"
                     /product="glycoside hydrolase family 9 protein"
                     /protein_id="WP_248064459.1"
                     /transl_table=11
                     /translation="MNTGLRQADAAAGDHNYAEALQKAIYFYEAQRSGPLPANNRVEWR
                     GDSGMQDGADVGVDLTGGWYDAGDHVKFGFPMAASATMLAWSVVEYADGYEQAGQLEEI
                     KDNIRWATDYFVKAHTKPNELWGQVGAGNTDHAWWGPAEVMQMNRPSFKIDASCPGSDL
                     AAETAAALAASSIVFADDDPAYSAKLLQHAKELYNFADTYRGKYTDCITDATAFYNSWT
                     GYEDELAWGGAWLYLATNDNAYLSKALSAADRWSTSGGSANWPYTWTQGWDSKHYGAQI
                     LLARITSSLNMPEATKFIQSTERNLDYWTVGTNGGRVQYTPGGLAWLDQWGSLRYAANA
                     AFISFVYSDWVSDPVKKSRYQNFAASQINYILGDNPRQSSYVVGYGQNPPQHPHHRTAH
                     SSWMNNEDIPANHRHILYGAMVGGPNASDQYTDDIGDYVSNEVATDYNAGFTGALAKMN
                     LLYGQNHQPLANFPAPEVKGDEYFVEAAVRSSGSNYTEIRALLNNRSGWPARMGDQLSF
                     KYFLDLSEVYAAGRTVSDVQVTISSSEGATVSQPVVVDASKRIYAITANFSNTKIYPGG
                     EGNYRKEVQFRITGPQGAWNPANDPSYQGLSTGNPLKSNYIPVYDAGVKVFGQEPGVTP
                     VTVPAAPAGVQAVAGNSQVALNWSASAGAVSYTVKRAAVSGGPYTTVATGINGLTYTNT
                     GLTNGTTYYYIVTAVNTAGESPASVQVSGMPQAASTVPGALTLSGTAGNNQNMLSWTAA
                     SGASSYTVQRAAAGGAYTDVAVGVTALNYNDTTALNGTAYSYRVVAVNASGQTLSNVVM
                     LTPSGPPASTGTLEVQYRSGGSGNSSNAVTPQFNVKNTGTQSIDLSTVKIRYYFTKDGT
                     EDMSFWCDYAQVGSANVQGKFVAVNPAKGTADTYVEISFTSGAGSLAAGAETGVIQTRF
                     SKNNWSVFDQSNDYSYDASKTAFAAWNKVTAYQGNTQVWGLEP"
ORIGIN
        1 aaagctgagc attacgccag aagatggtat ggtaagtctg gatgtggatg taaaaggcac
       61 ggacgcagtc tatgtcgaga tcgtatccga agatccgggt tcagctctgt ttgtaccgct
      121 cacaacatct tatctgacga agtaaaatag aacatttaca tgggtgcacc aacgaaggtg
      181 acttaaaaaa acgattattc acgatgtatc tccgctttct attcagagat gaatcatcgt
      241 gataatcgtt tttatttttg ctgcatagca gaaagatgtc agtgctgatt acactcttaa
      301 cgaagcatcg tatccagcgg tttcagattg gcttcgatct ctgcgcggcg tccttcaagg
      361 aaaggaggca gggccagtga ttctccgagc gtggcaaagt cctcatcggt atcaaatccc
      421 gggccatctg tagcaagctc gaacaagatg ccgttcgctt cccggaaata caaggaacgg
      481 aagtagaagc gatctacaaa accggagctt gggaattgga actgatgcac ccggtctacc
      541 cattgtctca attcctcttc attatctaca cgaaatgcca catggtgcac actgccgcgt
      601 ccaggacgtt cctgctccag atcggtgcgt tcttccaggt gaacctcgga accgctgccg
      661 cctgcgccgg attcaaatac aagcacatcg ggttgacctg gcgtaaaggc tggatagctt
      721 cctttcgctc tgaagccaag caggtccgtg agaacaggtg cagtgagtga agcgtctcgt
      781 accgtcagat ggataggacc taatccgacg atgccgtatt cggctggaac agggctttga
      841 tcccatggtt tgccgccagc aacgcccgaa ttatgctcat cggaaacgag aatcagccgc
      901 atgccttcga agtctgtgaa agccagtgtt gcacgtcctc cacgttctac aatctcgcca
      961 tgaggtactt catattcgtc aaagcgctgc acccaatact ggagggcggc atcgtttggc
     1021 acacgaaggg aagttgccga gatgctgttc acgccttcgc gtgtacggcc tgccatagga
     1081 atttcgaaga aggtcagctc tgtacccgga ttgcctttct cgtcgccata gaacaggtga
     1141 tatacggaca cgtcatcctg attcaccgtt tttttgatca ggcgcaagcc cataacatcc
     1201 gtatagaagc ggtagttctg gtcggcatgt gcagtaagtg cggatacgtg gtgaagtcct
     1261 ttgattaaca taatagattc ctcctgagaa ttataattta gggtaaagct gcagcacggc
     1321 ttgatattaa ataacgtcat tgtttaagat tcagatcatt ttgctctcac gatgaccata
     1381 aaataattat acttattaaa gttactaact tttagtacgt tttgttcttg tttttatctt
     1441 aacataaaga tatttaaaat gcaatgctaa atgcaagtga aactggacag ctgtatcgtt
     1501 cggtggcaaa atgaggaaag ttaccatctt agtggtgaga tgacacattt ctgtgaacct
     1561 ggtccaaagg ggagaagtaa agcatggctt atgcaccttg gcttgatccg tatgatgcac
     1621 cgccctttat agcactctcg acttcacata tgatatctat gaccattatc gttctacttg
     1681 tgctgctgtt attcctgttt cgtcattcgc ttcgcagact gtcagaacgt tcgagccggc
     1741 tgctgcgtat aggactggca agtatgatga ttggcagtga gatcctgctg cagctctggt
     1801 atgtgtatgg aggcatatgg agccttcaga cctcactgcc attagaactg tgcagcctga
     1861 cattgctgtt atcagcctta ttattattaa cacgtacacg gtggctgtat tctgctgtgc
     1921 tttttgcagg cattgcaggg gcattgatgg ccattgtcac cccgaatctg ggatatgctt
     1981 atgcccattt ccgcttcatt caatttttta ccgcacatgc gatgattatt ctggctttgc
     2041 tgtatatgac gtgggtggag cagtttcggc caggatggcg atccgtggca ggctctatga
     2101 tttttgtgaa catagccgcc ttggtggtgt atgctgtcga tgtgctgcta ggcgcgaatt
     2161 atatgtttct acgccataaa ccgaacaccc catcggtgct cgatatgctt ggaccttacc
     2221 cggtctacat tcttggagaa gaggtattgg cccttgtgtt attcacattg ttatatatcg
     2281 tgctctttgc cattcctgat cgtgtgaacc aacatcacaa cagaaaaaag acgaagactc
     2341 atcagattca atccaaactg taatgtcgat gtatgagctt tgaaatagat taacccgcag
     2401 acgttctggt tagccagagc ttttgcgggt tatttttacg ttaaaagacg ggaatctatc
     2461 gaatgaccta cccgcgcaga agagattctg caccatccac gtagatccgt gtgcctgtca
     2521 catgagatgc ttcatctgaa gcaaggaaca ataccagatt cgccacttgc tccgatgtac
     2581 ctggctcacc cttgagcggg tgctcatgac cttctggaaa ctccactgga atctgcacat
     2641 ccttcaaatc atccgatgga tacgtattat catcaatatt ggtatcaatc gcgccaggac
     2701 agactgcgtt gacacgaatt ttgtaacggg ccagctccaa tgccgccatt ttggtaaaag
     2761 cggtttggcc agccttgctg gaagcgtatg cagagaaacc gatcccggag aatacccgat
     2821 tgccgttgat cgagctggtg ataatgatgc ttccaccgcg ctccttcaga tgagggatgg
     2881 catacttcac tgtggcaaac gtaccgcgca tgttgatctc catcgtctgg tcccaatctt
     2941 cgatactcat cgtttcgatg ggggccattg caccattgat ccctgcattg gcaaacacaa
     3001 tatcaagctt gccggcttcg gctgctgcct gttgaattgc cttctgtacg tcttccggct
     3061 tggatatatc acattctatg acgtaagctg tgccaccgtt gttctcaatt ctatgttttg
     3121 ttttctcggc gttctctgga gtgcgatcca gcatatagac cttggctcca tgctcggcga
     3181 atcgaattgc ggaagcctga ccaatcccgg agccacctcc ggtaacaatg gcgaccttac
     3241 cttgcaaacg ctgttcagcc attactcatc cctccatgat ctaaagtttc cttagacgct
     3301 ttactttcta aatacccggc acgggagagg tgaatcatat gtatgcatat taaaaaagga
     3361 gccgcatccg gccccttggt ttacaaatca cccaatattt tgtgattggt ttcaatcttt
     3421 catttacttg tgcttcttcc agtccattga gctgttattc agcaagtatt caaaatcatt
     3481 atcccgccgc ttctgctcag ccttgcgggc ttcttctgct tgtaaacgct cttgctcctt
     3541 acgcgcggct tcggctgctt tggcttcatc ggcctgggct ttcaacttct ccagcacatc
     3601 actgctgagc agatccttca acgttgtagg ctgatcttgt gcctgagccc gggctttggg
     3661 agcaggtgcg cgtcttttgg attttgccat agggaacatc tcctttcgca acatgaatca
     3721 gattacacat cataacacgc cttagtatat caggttcacg cttttcattc catgaagtcg
     3781 gcgccggaag gcaggaaaaa gggcatggca tggcgaatga acacaggtat aaaatcatat
     3841 aatgataccg atacttcgac tattccctgg agaaaggagt cgttgttcgt gcatgtgaat
     3901 cgtagtttat tgaaagggct tgcatgggga atggccctca gcgtcccgct atggcttgcc
     3961 attataggct ggctgcgtct actctggttg atgcattgag gatgctgcat tggcgctatg
     4021 aaatggattt atatataggt attaatgtaa acgttatcat taaataagct ctgttccgcg
     4081 ccgagtgcac agaacagagc ttttgtttgt tccagagtaa ccgtgtttac ttggtgtccg
     4141 ttgtaatctt cactggttcc ggatattcaa tgccgtgggt atccaccgtt acttttttca
     4201 taatctgatc tgtaacaggc ttgtctcctt caccaatctg ttgtgccgcg atgccgtcaa
     4261 caacgtccat tccttcggtt accttgccga aagtagcata ggagttatcc agatgatcag
     4321 cgtcagccag catgataaaa aattgagaac cggcagaatc cagattttcg gatttgcgtg
     4381 ccatggagat aactccacgc gtatgcttta aatgattttt atgaccattc gaggtaaact
     4441 cacccttaat cgcatatcct ggcccgcctg agccattccc gttcggatca ccgccctgaa
     4501 tcataaagcc tggaatgacc cggtgaaaga tcagaccatc gtagaagccc ttgttcgcaa
     4561 gggagatgaa gttatacacc gtattgggcg caattttggg atatagctca attacaatct
     4621 tctgcccatc ctgcatctca atcgttgcca ccgggtctgg tccttctggc accgccggaa
     4681 ccggcgtttg ataagcattg tttgcagggc gtccgcaccc gctcataacg atcagcagca
     4741 tcgccagtac gagcgaaact gcggttgctt ttttccaccg taaagacatg aatatgatcc
     4801 tccttgattc gatcttcaac tatcataccg ttttcagatg cagaatggca atgtaaggca
     4861 tgttaatctg gtgaacgggg atggtcttca tagaagcata ggtgtaaaat aaggaaaatg
     4921 cttccgcatc agggggacgt acgggtctgt tccgttcgct ccatacacgg cagtcccggc
     4981 gtcggcttcg gaaaggacgt gcggatatat gaacttctcg tggaagcgta atctggtcat
     5041 attatggatc ggtgtctttt tttgcagtac ggcatattcc atctctattc cgtttttgcc
     5101 tttatttctg agcagtgatc tgggggttcg tgaccatctg gaattctggt ccgggctggc
     5161 cttcggcatt acgtttcttg ccagtgccct tgtatccccc ttctgggggt cgctggcaga
     5221 taaatatggg cgcaagccga tgttaattcg ttcagggtac agcctggctg tcctgtatct
     5281 gattaatttt tttgtacagg acccgtattc actcattgta gttcgtcttt ttcaagggct
     5341 gctcgccgga tttgtgcctg cggcgattgc actggttggc acgaatacac ctgaagagaa
     5401 gactgggtat gccttgggca ttatgtcaac ggcgggagca acaggtggca ttatcggtcc
     5461 gctgcttggc ggacttgtca gtcattatta tggcaatcgg agcgcatttc tattttcggc
     5521 aattgttgtg ctggtgtcgg cggtcattgc caccttttgg gtcaaggaag aaaatttcaa
     5581 ccgcaataag gctcgctccc atgtcatgga tgatatccgt gaagccagag caaaccgtgt
     5641 gttcattact gtgctcgtca tgatgggcat ctgtaccttt tcggttatga ttctggaacc
     5701 gcttttaacc gtgtatgtga tggagatggg gatacagccc gatcgtgctt cgttaagctc
     5761 aggcattatt ttctcggcag tcggagtagc cacagttatt atggctccac gctggggaaa
     5821 gctgggagca aggatcggct ttggtaaagt gatggtgatt ggacttgttg gcggagcagt
     5881 aggcaatcta ctgcagtttt tcacaacagg ttatgtagcg tttggtatcc tgagatttgt
     5941 ctatggactt ttcttcgcgg cggtgtttcc ggcaatcaat gcgatgattg tacaggttac
     6001 ggagccgtca tttcgaggtc gagcctttag tctgaaccag tccgcagccc agatgggcac
     6061 gatggccgga cccattatcg ggggcatact tggtggctgg ctgccgatac gctggatatt
     6121 cattattaac ggtgctgcac ttctggctac tgcaattgcg gtaaaatgga ccagattgga
     6181 gcataaactc cctggagcag gttcaactgt ggagaaacag tcccggcttt agatgataca
     6241 ttcaatttat tgtgaatcta taagtatagc tcagcattgt taagcaggat aagacaacaa
     6301 gcaaaaatca agatgacact gcgcaggtag tggtcatctt ttttgctgta tgaatgggga
     6361 caaggcttgt aatcaaacca aagaaacccc gttcagtggg gtctctctgg tcagacttta
     6421 acttcatgcg tagcttaatg cagcagagta atgttctttt ttgctcgtat gacaatgggg
     6481 tgttataagt taatccgaat ccgaggcggg cttgtcagaa gactgttcct tgggaatagc
     6541 gtgttcaatg gcttgccgct gatcttcatc ctccagtgcg cccggaaagg aatcttcggt
     6601 gaacagtcca aaatcgggat caatatctcg ctcagtaacc aggttatccg gtttttggac
     6661 ttgtcgttcc tcagcattat tgctcatgat gacacctccc tgattcagat tttttgcacc
     6721 atccacttcg atgacagaac aacctggaga gtagcggtta tccccagatt cttttgattc
     6781 ccttttccaa aggggaaaat ccggtgataa aggcgaagct tatacttccg atgtagcttt
     6841 ctttcagaaa gcttttagct ccgcttcttc agtttttttc tgtcctcttc gttcacgtgc
     6901 aaatgatagt tcagcttatt tagcgcggcg gcaaaatgtt tcgttcaggc tttgcatcag
     6961 ccccggcgcc atttaacaga tctgtcccgt gcagggcgtc cggatcgggt gcggccgggt
     7021 ctaccgggct gccgggctgc aacaggtcgg catcaggtac agattccagc ggaggctcag
     7081 ccaggcggga ttccagaaat tgttcatcca tacgatcacg ttctgcgtta ctgatgggtt
     7141 tatcagacat gaaaaacact tcctttcatt agaatgaatg gattaaacga tatgttttca
     7201 gtagtagtat caagcatgat attattcccg agaagagtat ggcttatgtc agtgttcgtt
     7261 aaaatttagg aaacacgtat ttcaccagaa agtagagaaa tccaaaaaag ataatgatat
     7321 aggcagcata tttaataaac gtggaagcga ccttacttga atctgatttg tactgcacat
     7381 ccttgtgttc aacttctacc gtgcgatgtg gctcgttcat cataatcatc tccttgtttg
     7441 gtgagagttt gctttgagaa accattacac acgatgcagt ggattgaatc gcctgttgct
     7501 gtttttagag ccattcgtgt ttgggctatg gtatgatgaa gcttgaatat gcaaggaggg
     7561 ggatcttgtg gattggttca cactaggcaa tatgattacc cgtattcgaa tcggacaaaa
     7621 ggcctcgact cccgggttct cccgcacggt tatacggcgg ccggacgggc tattctgggt
     7681 tggtggaatt tgggctggac aagtagtcca gctgcgtgat tttctgttct ctgacatttg
     7741 gaccatctac gatgatgatg agacggagca gtggcttgag tttcgaatga aagtagagca
     7801 gaaggaacgt gaaatgattg taaatcaatt cgaggacctg cgtgagtagt tctattttca
     7861 taacaataaa atggaaaaaa aactattaat ctactttaat gtgaattgtg taatttaata
     7921 agaaggtgac aagatcaacc gtggcgaatc ctataaaagg atacatgtga agagaaaata
     7981 aatactttga ggtgctgtga atgagaaatg tacccaaagc tatcatcatc ctgtggatga
     8041 cgatatggat cattctgttg ccgaatgggt tagtgtttgc tgcagcggaa gaggtccggc
     8101 agcctgaagc gatcacagga tgggaagtga aatggggaga cgcgaacgat caaggcttca
     8161 ttagcgaagt aatgggcgag gacgagattt gggagaagca gggcgctggc agaagtatgg
     8221 taacaagcca gaacagaatg atgcagcata ccgattcctt gtggacccgt ctggagattc
     8281 ccccattgca tgatgaaagc tcagcgattc gctttgagaa tataaaaggg acgcatatcg
     8341 taatctatct tgaagatcgg aaagtatatg aaaactatca ttacaattac gataataatg
     8401 ctgtattttt acccttatct gttgaaaact cggggaatac actctacata tggtcacaaa
     8461 atgagaatgg ctggctgggc ataaaaggtg atgttcagat tgggccttat gccatgttgc
     8521 aggaaaaata cattcataac ggtttaattg atgttatttt gggctcgacg tttatattta
     8581 cctcacttgt tatgctcagc tgtacatttt tcctgggtca gttccataaa ggtctgtgga
     8641 tgtcattatg tgttgtgatg ggttccattg gggtcatggt tataacgtac tcgcagtttc
     8701 tgtatacgtt ctatcaagtt tatggtgatt tgtattctct tctctttgat ctggccatgc
     8761 tgctgggtat gcctgctctc tgttattttt ttgaacaaat tattggtcca ggagtctatg
     8821 gcatattcac caaactacgc aaaattcaat gggcctattc cgttgtagcc gtgctctcat
     8881 tgtttatata cgtcataaca ggcggacaat gggattggtt atacaatctg tttgtgcaga
     8941 atgtggtggg cttcgtgctc gttattttgc tgaccattct gttcgttggt acaattgcca
     9001 aggcattaca acgcaatcgt gaagccattc tgttagccac cggttttggc gtattttctt
     9061 tgatcagtgt acttgagctg ttgtggtact atcagcgcaa tggcacgtat catctgctct
     9121 ggtggaagtg gtctatggtt gcgtttgtga tttcgttgat tgcgattctg ggaagccgtt
     9181 ttgcggaaaa gcacaataaa gtgctgcagt attccaaaga attggaactg tttaataatg
     9241 agctgcagcg gtctgagaaa atggaaatca ttagcgaact ggctgcttca gttgctcatg
     9301 aggtgcgtaa tccacttcag gtgacgcgag gattccttca gctcatgacc gagcaggagg
     9361 ataacaaaaa caaaggatat gtgcgaattg cactggagga acttgatcgg gcttcgggga
     9421 ttattactga tttcctgacc ttcgctaagc cggaattcga tcatattata tcgttgaaca
     9481 tttcggatga atttgatcat atcgaaggca tacttgtacc gatggctaat ctggaaggcg
     9541 ggaaaataac aacagatatt ccgccgaacc ttcatattcg aggcaattcc tcgaaattca
     9601 agcaggcttt tatcaatatt atcaagaaca gtattgaagc gctccagggg ggacaaggtc
     9661 agattgatat ctgggcatac tcgcaggaag gcaaagtcaa agtacatgtc cgggataacg
     9721 gagaaggcat gagtgaggag gctttatccc gtctggggga accttacttc tctaataaaa
     9781 tcaaaggtac cggattaggc atgatggtta ccttccgtat cgttgaagca atgaatgggc
     9841 agatcagctt tacaagcacc aaaggggtag gaacagaagc tgtggtatct tttcccgagt
     9901 ttgttgaatg atgaactcgt ctaagatacc cagcttgatg ttctaccctt tttttatttc
     9961 tattcaagtt aatgttcgca gagcctcgaa tcaggtacgc ttaatttctc cacggaccac
    10021 aattgacatc atagtttact ttggaagggt taggtgggat cacaagcaca taatcatttt
    10081 gctgctcctc gaccgtacga accctgatat gatctggaat cgtaataccg aatgcctcgc
    10141 gaagcgcttg ctttggattg gagtgcagtt gttgtctgaa tttctcgtct gcccaagcct
    10201 tctcaataat gtcctcgtgc aatgttttct ctgataccat cataaccaac attcccttca
    10261 tatttaaatt aaaccgaatc agcgttccct ttctcaggta acatagatga agattcgctg
    10321 atccagtagt gaaacccgcc ttgataaagt ctttttttgc gctgttttat atccagaacg
    10381 gcttgtacca atgcattgta cagataggaa ttcaatacaa tgtattgtgg caataccaag
    10441 ttataagatg ttaatgcgtt ttggaactga gatgcaatct cggcgtagct gtccatgaag
    10501 tatgagttgt atatatgatt gagtatggaa tcgttcactg tatgaattgc ataatcatga
    10561 tggagagcag cggatatatg tgagaggtag ctgttgtaat tgccatgcac agcatcttgt
    10621 ttcatatctg tgaagtcatc tgtcatctgc agggtcatca gcacaatgtt cagtgcatca
    10681 cacatcgaag tgatgcgtgc cggttgttct aatagaagta gtgagccgat agcaccaagc
    10741 tgtgagggtg aagctttctg ggcaatgaga agtgggttta gctgaaaata atcgatgtgt
    10801 cgttcaccat ttacacttac ggcccaatct tggataactc gtctgaaatg cacccagaat
    10861 acggatgaag gttcaaacaa caagctgtag agctgaagag catcaacata atatagattg
    10921 cctaaggtca gcttcgctac agcatcctct tcaggctcat ccataacatc gtccatattc
    10981 agaaaatata acatatgcag cagacaggct gtgccaagta aatgtgcttt gtccaatgga
    11041 agtccatcgg tgtggtgcat ccataatgga gagatataac cgatgcagct cagtccagaa
    11101 tcagttctga caggatgaag ctgatggagc tgttcaagtg catgcctggc cagtggctca
    11161 gggtattgtc gaagcttgtc ttctgccgca gcgaataagg cttctacatc aggggtatac
    11221 ggatctaacc attctcgccg catcatcgag caacgtcctt cctgccacga aatagaaatc
    11281 ctatgtttag ctacagaagt tacatccagt atatctcaaa atttttgaaa aatataggat
    11341 tttttgtgat catttgtgaa aaatttgatg acatttcgta tgatttagca taaaaagcag
    11401 taatttagga tcagactagg gaggaagaga atatttgaca taggaaaggc ggaaaaagat
    11461 gaaaacgaat tggaagacaa gagtggcagt tgcagtggct gctgtaatca tatctgcagt
    11521 acctggacct cgtgtattgg ccagttctac tatgcctgtg gagcagggga aggcagtatc
    11581 tgctgaatca gcaacacagc ataagaagcc ctgtattcat gcaggtcatg gcctgtttat
    11641 gatcggtgaa actgcagaaa tgcttggcat tgggcttcgt gatctgaagc agcagatgga
    11701 gcttggacat acgcttgccc agatcgccaa ggaacgcaag ggcctcagtg aacagcaatt
    11761 gctgcaaaaa ctaaagcctg cgctatcgga gcgtctggat caagcggtaa cagaaggctg
    11821 tctgacgaaa gaacaagctg cagcagccaa agccgatatg gatgtgaagc tgaaaaaggt
    11881 ggtaaacacg ccgcttcgtg aattgcgacg ggaatttgca catcatggta aacattcaat
    11941 gatcaataaa ggagctatcg caaggtatat cggaataact cctgaacagt tacaagagca
    12001 gctgcatgcc ggcaaatcgc tggctgaaat agctcagaca aagggcatca gtgaaacaca
    12061 gctcgtgaat cagctgaagg aacagctgac aggtgatctg caaaggtttg ttcgtcaaaa
    12121 gcatctggag catccggttc cggttcggcc agggcatgta cctggaagag cagcttcgac
    12181 ggatgaaaaa taggagcagt ttatcaatta agctgaatga aagctacgct ggaaactgaa
    12241 agagcactct cctgaaaaat taggggagtg ctcttcgggt ttcgggttag cctgaatgtg
    12301 aaggttgtct ttttacacgt gtttgagtgc tgctaagcgt attggatgcc ttggctttgt
    12361 atcggtggcg tgatagtcca actgtgaaac gcgacccggg cagcttagac agcccccagc
    12421 tgatgcccag cgcggtaaca acggtaatcg caaatgacag taccgtggcg agtagatgcc
    12481 acccgctgag gtgcaaaggt ctcgtaaaat atgcaatggc atagattacc agagcatgca
    12541 ccagatagcc gccgaaggaa taacgtccaa tccagtcaag caggcgcctg aaccccaggt
    12601 ctttatcgcg gaatagtgcc agcagaccgt agaacataag catttgagcc atgataatga
    12661 tgaaagtact cggcttcaga taggtggaga tgttaagatt cattgtatct tccgaaccac
    12721 gcagcacatc atatcccagc cagatataca tcataataaa aacgataatt gtccacggga
    12781 ggactttggt cgtccagcct ctccagtttt caaccgccca ggcgcataca gctccaagca
    12841 aaaagtaaaa ccagtacatg atccatgaat acgaccgata ttccagcaga ctcgaccaag
    12901 gctcagacag aagattagtc cagccggaca tatcataata cgaccatttc aaaagacaca
    12961 cgtacattgc agctgcggca agtattatgg ctagagtccg ctgcccagaa gtaaggcggc
    13021 tgtgggggtt gctttccagc cgtttacgaa cagcatgggc ccctgttaaa aacaacggga
    13081 acagaatata aaactggaaa atcatcagga caaaccaaag atgatatccc gtctgcggta
    13141 aaaacagttc ccgtacgaag ctgcccaggt ccggcatgcc cgaggaccag aaggctgggg
    13201 taaacatgcg cacagctaac cagtagatca gtgtccatat tataaatggc atataaatat
    13261 ccccaaatcg ttttttaatg aagcgtgcat aattcggctt ggcatggcga tgatggtaga
    13321 ataacagcgc acccgacaga aacacaaagg tgggtgtacc aaatctcgtt agatgataaa
    13381 tcatcgttaa catcacggaa tcgggctgtt caatatccgt ccgataaata tactcagcaa
    13441 tgttatgctg cataacaatt gccaggaaag ctaacccgcg gagttcggtc cattcggcta
    13501 ttttcggttt tttcataatg cattcctccc ttatgaagcc agggtcatcg tataagacta
    13561 accttcaaac attaaaagcg cattaaatgt tgaaaataat taaaaaaaag acggcatagg
    13621 ccgtctctta ccaggaaatc agcatcgcgc agatgctgct cattcgtttg atgttggttg
    13681 tccagtctct gcttcgttcg aatccgaatg atcttcttca aacaatttct gaatgtaggc
    13741 ttgaagtttg ggtacgttca caccgagtac ttgagcgcta ccagcacgtt catttgttag
    13801 gagtttgttg ggtggaatct gatgctgatt catttcgttt acacgaatat caaagccgag
    13861 cgaagccagc ttcagcatct gtgcgggact gagatcggtt tgaatatagg gagcaacggc
    13921 ttcaaggatc tccgggactt tgaagagtga agtgctgctc tgcattttct tcgcgagctc
    13981 ggtcataaag atccgctgcc gttgtgttct tgtaaaatcg gatgtggcat catgccggaa
    14041 gcgtacatat tgaagggccg tttttccgtc catatgctgc aatccttttt tcaggtcaat
    14101 gtcatacata tgtttatccg ctttacttgt ataatacata tctttctcga catcaatatc
    14161 aatcccgccg agtgcatcaa ccagcgctat gaaacctgta aagtctgtgt agacgtagtg
    14221 ctggataggt atgcccagca ggttgctgac cgtttgtttc gttaattcag ctcctccgta
    14281 ggagaaagcg gcgttaaggc ggcttttgct atgtcccgga atatcaacat aggtgtcccg
    14341 cagcacggag aatagatgag cttttttgga aacgggatca atagaagcga ccatcacgga
    14401 atctgaacgt cccgcatcat cacctctgga gtcaccgccg attagtaata tgttgacgcg
    14461 ctcctgcccc tcccacttgg ggatttggac cagagacgca ttcgagtttt catccttgtc
    14521 tgaaccatca ttggaggacg aagcactggt gaccgttgag atgctattgg caaaatgaac
    14581 aatcgaatat ccgtaataaa taatgacacc cgttacagca aggaccaagg tcaggactgt
    14641 cccccacaac catcttttaa gcataatctt cacctttcta tgtaagaact gaacagcacc
    14701 caaactattt taacaaaaag aaatagttat gtcctcttta attccgaaaa acatataata
    14761 ggaggattta ttcgacaatt tgtttattta taacttatca tgcagacgat ttgttgattt
    14821 catgggcttc ttttcactga taatagactt tatattatct ttttcgatgt gttttatttt
    14881 tcctgttata tgaaatttta tggattgcta atgtcatata ttcaattgcg cactatacat
    14941 gtcgatatat tatacagatg tatcagttta acgcgccaag ttggaggagt gggatgatgg
    15001 aaaaagcacg ggggaacgta cggggcaaaa tgaggtttac gatcaggggg aaattgttag
    15061 ccggtttttc aattgtttta gcattgctta tctttgtgag tgtgtataca ctaatgcagg
    15121 tttctacaat ggctgatcaa tctcgccaag tcaacaaaac ctggatgccg agtgtaagcc
    15181 tactgggtat tatgaatggt gatgtctcgg atgtggaacg gctggcactt gccgtcatcg
    15241 ttgagcagga tccaagcgaa accgagaagc tgaatgaagc gttaaacgtg gtgcttgcca
    15301 aaatcgagga tgagcgtaaa gagctgctta ccttaatcaa gggaaatacc gatgctgaga
    15361 agctgtacga acagttttca acgaattatg atgcatatct gcagaaacag ccgtctttta
    15421 tcgaaaatgg tctgaaaaat gactatcttg cagccagcaa actgcataca gagtcatatc
    15481 cattatggta tgcggctaac gatagcatta cacagttgat taacctggga aataacggag
    15541 cgaaggaaat cgctgccgag tctgtcaaac ttgccgagaa tgcatttagt atcattttgg
    15601 gtgtagcgat tgtcgcaaca ctgcttgcat tgttcattgc tttctttatt gcaagtatga
    15661 tctcacgtcc actcaaaaaa atgacggagg ccgctacagc aattgctgaa ggtgatctca
    15721 ctggtgagag cattgtactg aaaaacaggg atgagctagg tgtgctggcg acagccttta
    15781 atacgatgag tggtaatctt cgttccatga ttcaatccgt atcggagaca tcggagcagg
    15841 ttgcggcttc atctgaagag cttctggcca gcgcggagca aaatacgaga gcttcggagc
    15901 agatcaccga gacggttgag gaattgtctg taggaacaac cgatcagatt gatcttgtga
    15961 agcgttcgtc ccaggcgatg aacgagatgg ctctgggctc tgaacagatt gcggagctgg
    16021 ctcaaagtgt atctgtctct gctgtggatg cggcgaatca atctactgaa gggaacaaga
    16081 ttattcagca ggcggttgaa cagatgggaa ccgttcgtaa ttcgattgct tcactgagag
    16141 tattggtcac agggcttggt gagcgttcag ccgagatcgg taccattact gaagtaatca
    16201 acaacattgc gcgtcaaact aaccttcttg cattgaatgc cgcgattgag gcggcacgtg
    16261 caggagagca tggccgaggt tttgctgtcg ttgcgggaga agtgcgcaag ctggctgaag
    16321 aatcttctgc ttcagcccaa cagatctcag agattgttca gctgattcag caggacacga
    16381 atcatgctgt agaggctgtg aaggtaaaca gtaacgaaac ggaagcggga attgaactgg
    16441 ttgctgcagc cggacaagcc ttcgaacaga tctcaggcgc tgtcaataag gtagcagggg
    16501 agatcgagga agtatccgcg ggttctgagg agatgtcagc aagtacgaat gaggtcatga
    16561 gttatgtgaa tcagacctcg aatattgccg gagaagctgc aggtgctgta cacaacgtat
    16621 cggcagctac acaagagcag ctggcttcta tggaagagat tgcttcctcc gcaagcctgt
    16681 tgtccaaaat ggcagaggag ttacaggggc aagtcaacaa attcagagtg taacgttcaa
    16741 atacagaata gaaaaagctg tttctcccgg agtttccggt gaagaaacag cttttttgtc
    16801 ataacacgcc acctgaaagt cacaacaagg tcacaacaat gttatttcag aagtcaccaa
    16861 tgttgatatt gcatgctgta caaaagacta taatggtaat taatggtgga agttgtatgg
    16921 agttaccacc atagagagga gcgcatgtac ttcgaaacct acaagttttc aagcggaact
    16981 ttcaagaaaa ggagatgaat cgtatcgatg aaagggagct ggtggagacg agttgcaata
    17041 gcgacattat cggcaggact gctggcaggg agcttttcga tgaatacagg attacgtcag
    17101 gcggatgcgg ccgctggaga tcataactat gccgaggccc ttcagaaggc catttatttc
    17161 tatgaagcac agcggtcggg acctttacct gcgaataatc gggtggagtg gcgtggtgac
    17221 tcgggaatgc aggacggggc ggatgttggc gtagatctta ctggcggttg gtatgatgcc
    17281 ggggatcatg tgaagtttgg ttttccgatg gctgcttcag ctacgatgct tgcctggtct
    17341 gtagtggaat atgcggatgg ttatgaacag gcgggacagc tggaggagat caaggataat
    17401 atacggtggg caaccgatta ttttgtgaaa gcgcatacga agccaaacga attatgggga
    17461 caagttggag cagggaacac ggatcatgcc tggtgggggc ctgccgaggt catgcagatg
    17521 aaccgccctt cgttcaaaat tgatgcgtcc tgtccgggaa gtgatctggc ggcagaaacg
    17581 gctgctgcac tggcggcttc ctctatcgta tttgctgatg atgacccggc atactcggcg
    17641 aagctgctcc agcatgcgaa agaattgtac aactttgccg atacatatcg gggaaaatat
    17701 accgattgta ttaccgatgc gactgcattc tataattcct ggaccggata tgaggatgaa
    17761 ctggcatggg gcggagcctg gctttattta gcaacaaatg ataacgctta cttgtccaaa
    17821 gcgctgtccg ctgcagatcg ctggtctacg agcggcggtt cggctaactg gccgtatacc
    17881 tggacacagg gctgggatag caagcactat ggtgcccaga ttctgctcgc ccgaattact
    17941 tccagtctga atatgccaga agcaacgaag ttcattcagt ctaccgaacg aaatctggat
    18001 tactggacgg taggaacgaa tggaggccgt gtccaataca cccctggtgg tctggcctgg
    18061 ctcgatcaat ggggctcgct tcgatatgcg gcgaacgctg cctttatctc ttttgtatat
    18121 tccgattggg tcagtgaccc tgtgaagaaa tccagatatc aaaattttgc tgcttcacag
    18181 atcaactaca ttttaggaga taaccctcgt cagagcagct atgttgtcgg gtatgggcaa
    18241 aatccgccgc agcatccgca tcatcggacg gctcacagct catggatgaa taacgaagat
    18301 attcccgcga atcaccgtca tatcttatac ggcgcgatgg tgggaggacc gaatgcgtca
    18361 gatcaatata cggatgatat cggggattat gtaagcaatg aggtagcgac cgattacaat
    18421 gccggtttta ccggggcact cgcgaagatg aatctgctgt acggacagaa ccatcagccg
    18481 cttgcaaact tccctgcacc ggaggtcaaa ggtgatgagt atttcgtgga ggccgctgta
    18541 cgctcatccg gctctaatta cacggaaatc cgcgcactgc ttaacaatcg ctcaggttgg
    18601 cctgcacgta tgggcgacca gctctccttt aaatatttcc tggatctgag cgaggtgtat
    18661 gctgcaggac gcaccgtatc cgatgttcag gttactatat cgtctagcga aggggcaacc
    18721 gtttcacagc ccgttgtggt ggatgcctcc aagcggatct atgccattac agcaaacttc
    18781 agcaatacca aaatctaccc gggcggggag ggcaattatc gcaaagaggt tcagttccga
    18841 attacaggac cgcagggtgc atggaatccc gcgaatgatc cttcgtatca gggcctgtcg
    18901 acaggcaatc cgttgaaaag caactacatt cctgtctacg atgccggagt gaaggtattt
    18961 ggacaggagc caggcgttac ccctgttacc gttccagctg ctcctgccgg tgtgcaggcg
    19021 gtagccggca atagccaggt ggcgctgaac tggtcggctt ctgccggagc tgtatcgtat
    19081 acggtgaagc gtgccgcagt tagcggaggc ccttatacaa ccgtagccac aggtattaat
    19141 ggactgactt acaccaatac gggactaacg aatggcacaa cgtattatta catcgtgacc
    19201 gctgtgaata ccgccgggga atccccagca tctgtgcagg tgtcaggaat gcctcaagcc
    19261 gcatcgacgg tgccaggagc actgacatta agcgggacag ccggcaataa ccaaaacatg
    19321 ttgtcctgga ccgcagcatc aggggcttcg agctacactg tgcagcgtgc tgctgccggt
    19381 ggtgcttata ctgacgtcgc agttggcgtg accgcgctga actataacga cacgaccgcc
    19441 cttaatggca cagcctacag ttatcgcgtg gttgcagtaa atgcaagcgg gcagacgttg
    19501 tccaacgtgg ttatgctgac gccttccggg cctcctgctt cgacgggtac gcttgaggtg
    19561 cagtatcgaa gcggaggctc aggcaattcg agcaatgcgg ttactccgca atttaatgtg
    19621 aagaataccg gcacccagtc cattgatctg agcacagtga aaatccgtta ctactttacc
    19681 aaagacggca cagaggatat gtccttctgg tgtgattacg cgcaggtggg ttcagccaac
    19741 gtgcaaggta agtttgtagc ggtgaatccg gcgaaaggta ccgcggatac gtatgtagag
    19801 atcagcttca cctctggagc aggaagtctg gctgccgggg cggagacagg tgtaattcag
    19861 acacgtttct ccaaaaacaa ctggagtgtg tttgatcaaa gcaatgacta ttcctacgat
    19921 gcttccaaaa cagcatttgc tgcttggaac aaagtgacgg cgtatcaggg caatacccag
    19981 gtatggggac tggagccata aaggcataca tgtagatgga agtgcagaag gccatgcaat
    20041 atttcaaaat tgaatagtta aaatgcggag caattgtggg aacagacgag cgacagtgat
    20101 attatttttc actaattcag ggaggtatat attgatgttg aagacagctg caaaaaagag
    20161 tttaacggcc atgctggcgg gaacggtcat gctgaccggt tacacgggac tctggactgg
    20221 ttctcaaacg gcgcatgctg ccgatcaggc cattgaaatt c
//
