LOCUS       NZ_JAHXMW010000002     22043 bp    DNA     linear   CON 13-MAY-2024
DEFINITION  Paenibacillus silvae strain EYE_43 Seq_2, whole genome shotgun
            sequence.
ACCESSION   NZ_JAHXMW010000002
VERSION     NZ_JAHXMW010000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Paenibacillus silvae
  ORGANISM  Paenibacillus silvae
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 797844)
  AUTHORS   Pu,J.
  TITLE     Study on the microbiota of ocular surface in healthy people
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 797844)
  AUTHORS   Pu,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-JUN-2021) New Pathogen, China CDC, 155 Changbai Road
            Changping District, Beijing 102206, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023149095.1-RS_2024_05_13
            Annotation Date                   :: 05/13/2024 05:30:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,071
            CDSs (total)                      :: 5,941
            Genes (coding)                    :: 5,912
            CDSs (with protein)               :: 5,912
            Genes (RNA)                       :: 130
            rRNAs                             :: 9, 12, 12 (5S, 16S, 23S)
            complete rRNAs                    :: 7 (5S)
            partial rRNAs                     :: 2, 12, 12 (5S, 16S, 23S)
            tRNAs                             :: 93
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 29
            CDSs (without protein)            :: 29
            Pseudo Genes (ambiguous residues) :: 0 of 29
            Pseudo Genes (frameshifted)       :: 8 of 29
            Pseudo Genes (incomplete)         :: 20 of 29
            Pseudo Genes (internal stop)      :: 3 of 29
            Pseudo Genes (multiple problems)  :: 2 of 29
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:11:56
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 331962
            Orig. end                         :: 354005
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAHXMW010000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22043
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     cand_cluster    1..22043
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22043
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:17043](+)"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..17043
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     misc_feature    229..244
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.21"
                     /tool="antismash"
     misc_feature    complement(690..707)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 18.7"
                     /tool="antismash"
     misc_feature    760..773
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.15"
                     /tool="antismash"
     misc_feature    complement(761..774)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.67"
                     /tool="antismash"
     misc_feature    967..981
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.84"
                     /tool="antismash"
     misc_feature    1258..1273
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.86"
                     /tool="antismash"
     gene            1258..1611
                     /locus_tag="KZX51_RS10210"
                     /old_locus_tag="KZX51_10175"
     CDS             1258..1611
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017687105.1"
                     /locus_tag="KZX51_RS10210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_10175"
                     /product="hypothetical protein"
                     /protein_id="WP_145406271.1"
                     /transl_table=11
                     /translation="MTILSTGPIENNAVSGVRPTKQVTIRIVSRVAAVVVSVQGYVLDT
                     TRTLYVSELISVAPNEALTRNYFADLDAFEFLFEINEANVGDVEISVWGKKASGELVDS
                     HRVVEHEKTITNS"
     gene            1644..3068
                     /locus_tag="KZX51_RS10215"
                     /old_locus_tag="KZX51_10180"
     CDS             1644..3068
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007408481.1"
                     /locus_tag="KZX51_RS10215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_10180"
                     /product="exosporium glycoprotein BclB-related protein"
                     /protein_id="WP_248170984.1"
                     /transl_table=11
                     /translation="MSFLSTGPIENNAVSGVRPTQSVTVRIDNRSDATVSTVLIQGYYM
                     SGGTRIQYVSQTFDIAPNQVITNNYFANLDAFEFTFTTTAQFNDPVQISVWGKSSTGSL
                     VTAHRLVSSELLGEILGTTGATGATGAAGATGPTGATGVAGATGPTGATGVAGATGPTG
                     ATGVAGATGPTGATGVAGATGPTGATGVAGATGPTGATGVAGATGPTGATGVAGATGPT
                     GATGVAGATGPTGATGVAGATGPTGATGVAGATGPTGATGVAGATGPTGATGVAGATGP
                     TGATGGTGATGVTGATGVAGTGAIIPYASGLPASLTTVLGGVLNTSSLVGFGSSTTGIT
                     ISGGVIDLTGSPGTLLNFAFSAPRAGTITSLAAYFSTTAALSLVGTTITITAQLFRSTT
                     PDNSFTAVPGAVVTLAPALTGILALGTISSGLTTGLSISVAASDRLLMVFSATVTAGID
                     VATTVPGYASAGLSIT"
     gene            complement(3495..>3821)
                     /locus_tag="KZX51_RS10220"
                     /pseudo=""
     CDS             complement(3495..>3821)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017687111.1"
                     /locus_tag="KZX51_RS10220"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="aminoglycoside phosphotransferase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="IHDELGPNHIIIDHKMQPYLIDIEGAGFFDLEHEHSFLKLRFGEY
                     YRYFEQENLDSARLSFYRLCHHLSLTSGGLKLLHRHFPDRQFAKNLAAYHARQALEMLS
                     HNPD"
     gene            complement(3937..4737)
                     /locus_tag="KZX51_RS10225"
                     /old_locus_tag="KZX51_10190"
     CDS             complement(3937..4737)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019535432.1"
                     /locus_tag="KZX51_RS10225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_10190"
                     /product="ankyrin repeat domain-containing protein"
                     /protein_id="WP_145404306.1"
                     /transl_table=11
                     /translation="MEWMYEDEAVAQRVTRAIQTGETSSLEQLLLEHSGLAKTRILERN
                     PQNKGACSTVSRTLLHIATDWPGHFPNVTKTIRMLTGYGAEVNAPMLGANHETPLHWAA
                     SCDDVQALDALIDAGADIEASGAVIAGGTPLDDAVAFAQWNTARRLVERGALTALWHAA
                     ALGKIDAIKNHFKGKTLPEYYPWASGSSSAPTDTVNISFWCACHGGQQEAAAYLLQQGA
                     ELNWAAAWDGSTPLDTAKRNGFTDLVTWLERQGAKGADNINREI"
     misc_feature    complement(4873..4890)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 18.49"
                     /tool="antismash"
     gene            5001..6452
                     /locus_tag="KZX51_RS10230"
                     /old_locus_tag="KZX51_10195"
     CDS             5001..6452
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_5"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF026257.4"
                     /locus_tag="KZX51_RS10230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_10195"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_145404305.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 3.2e-12, bitscore:
                     41.9, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEMSLLKKIMRSVAHKDNMAMDSKEDIDTMLGTISKHKLEPYVN
                     VMQGNSLPEIENRLTRIKEQYKRHITFLEKLRNTTEKPIVVVKGFSNYHASEGRVLLRE
                     TSDLDILSPHPVRLREELLASGFIEKKTETEHELSELEQDGILIDIHKFVPVASYPADI
                     EEICESNHYTTTEGMFFSGEISYNDIKEHSIEIIDNVLVPNVNMSLLISCVSMFRDYIT
                     SLEDVPNLKLINLVEIFILMHEPTFDPAEFIQMVRKYKAEHSIAFVNHLLLDIYDEQLV
                     DVGDNIKRFPQILFWSEKWIIPLDVVKSVCNTRFENVLELLGAEQKWLDEHHSLRMTAA
                     SRSPRYHTFNDEFDKQITLAVKWTDHLHISLEMTPFDQLHDHDIFRFNFGKSWNKIFLF
                     GSDEWGTSLFGETFNDYAGFVHKEGEQVLKIDILIPPEKLETYLLHKHQLGVNIYLEKH
                     ENNKQFSMYIPLFISKVSAGMKSIT"
     gene            6461..6979
                     /locus_tag="KZX51_RS10235"
                     /old_locus_tag="KZX51_10200"
     CDS             6461..6979
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003223684.1"
                     /locus_tag="KZX51_RS10235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_10200"
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_248085517.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2e-12, bitscore:
                     42.5, seeds: 75, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSALNSTTLSTPAEKILSVLQTNGYKHFSGVPCSLLKGLFALLEQ
                     SDASTMRYIPAVREDAAIGVASGFAIAGHKSVVLMQNSGLGYSLNVLTSFNMIYDLPVM
                     LLISWRGAYEHDAVEHDIIGDRLTPLLDAVDIPYIELETHKVEQSVIKAIEQMECTQKP
                     VAILIKDEV"
     gene            6994..7563
                     /locus_tag="KZX51_RS10240"
                     /old_locus_tag="KZX51_10205"
     CDS             6994..7563
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003223687.1"
                     /locus_tag="KZX51_RS10240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_10205"
                     /product="thiamine pyrophosphate-dependent enzyme"
                     /protein_id="WP_145404303.1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.7e-17, bitscore:
                     57.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKDEAIQLILDQFPIAYIVSTCGHITRDLYNKCDREEHFYMVGS
                     MGMAAPVALGLALANEHQQIVILDGDGSFLMNLGAAAMIGQQQPRNLIHVVLDNGMHES
                     TGGQRTIGMENMTTAVLSMGYKAGLKMDKHEDWQQLHHHEGPVLIHIKVDPRTEKVGKR
                     VEWTPQQILSRFSKAIRGETCELSAN"
     gene            7544..8557
                     /locus_tag="KZX51_RS10245"
                     /old_locus_tag="KZX51_10210"
     CDS             7544..8557
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003223689.1"
                     /locus_tag="KZX51_RS10245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_10210"
                     /product="aldolase"
                     /protein_id="WP_145404302.1"
                     /sec_met_domain="HMGL-like (E-value: 5.9e-37, bitscore:
                     123.0, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFQLIDCTLRDGGNLNQWRFSDVAIGQIIRGLDQARTDYIELGY
                     LGGSGSHSPGEVGKTFDCTSEFLDELPQTFHARKAIMIVPSVCSQEQLSKLHTSQVSLV
                     RVASYPQDTAYAMSYIAALKDRGFQVAMNLMAASYAEPDQVARVAVEAERHGADIFYIA
                     DSYGSMTPGDVRQYVEALKQSTDCEVGFHGHNNLGLAFVNVLEAMRSGASFIDTSLCGM
                     ARGAGNLPTEQFISALSHWEQFDTSYEVLPVVETADYVLNHVLEKPMRIAAPEIICGLH
                     NIHYYYYDKILDSRSGMQMQSAWNIAQSLGKLRPPKVHVSYVNKAIELTGGMKSES"
     gene            8547..9431
                     /gene="aepX"
                     /locus_tag="KZX51_RS10250"
                     /old_locus_tag="KZX51_10215"
     CDS             8547..9431
                     /EC_number="5.4.2.9"
                     /GO_function="GO:0050188 - phosphoenolpyruvate mutase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019634 - organic phosphonate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="aepX"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) phosphonates-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231: carboxyvinyl-carboxyphosphonate"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003223692.1"
                     /locus_tag="KZX51_RS10250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_10215"
                     /product="phosphoenolpyruvate mutase"
                     /protein_id="WP_145404301.1"
                     /sec_met_domain="phosphonates (E-value: 1.9e-126, bitscore:
                     416.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates-like (E-value: 1.2e-140,
                     bitscore: 462.6, seeds: 13, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 5.3e-69, bitscore:
                     227.7, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAKQLRDLLNSNKLIRVMGAHNGLSAKLAEQAGFDAIWASGLEI
                     SATHSVPDANILTMTENLQAAISMNQATSIPIICDCDSGYGNVNNVIRMVKEYERNGMA
                     GICIEDKQFPKLNSFIDGPQKLTPIDEFAGKIRAAKDTQSDPDFVVIARIEALIAGQGL
                     QEALNRAYAYEEAGADAILIHSKQKQPNEIVSFVEMYKGAAPIVIVPTTYPTLDVEQIR
                     DFGIQMVIYANHGLRSSIKAMKETFDRILREGHTAGVELDISTMQEVFELQGMFEMRQQ
                     EDKYSTGSVILNN"
     gene            9450..10709
                     /gene="thrC"
                     /locus_tag="KZX51_RS10255"
                     /old_locus_tag="KZX51_10220"
     CDS             9450..10709
                     /EC_number="4.2.3.1"
                     /GO_function="GO:0004795 - threonine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009088 - threonine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thrC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PALP"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009671698.1"
                     /locus_tag="KZX51_RS10255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_10220"
                     /product="threonine synthase"
                     /protein_id="WP_248062589.1"
                     /sec_met_domain="PALP (E-value: 9.1e-57, bitscore: 188.1,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLHCNDCDQRFELSEFRYACSCGGLLEVEQDFSRLDSDELKRSF
                     NQRLSDRMSPYASGVWRYKELIFPELEERHLVTKYEGNTGLYQADKVTQYTGLRKIWLK
                     CQSENPSGSFKDNGMVVAVSHGKSLGLDKFTCTSTGNTSSSLAMYSSLIDRQAYVFVPN
                     QNISLNKVLQTVAYGAKVIAFDGTYDQGIAFLEKHHPELGLYICNSINPFRIEGQKSII
                     YEIAQYLQWELPDWIVVPGGALSNVSALGKGLADLYALGFIRKLPRVALVQAEGASPFH
                     KMMSNKQDTLQPEPHPNTIASALNIGHPPSWKKARQTLRNTDGITVSVTDEEILNAKAI
                     IDQSGIGCEPASASTVAGLKKLHASGEIHADETAVCILTGHLLKDTEVLRKYHLENARG
                     ALFANPIRQSALDIDQIITL"
     gene            10721..11824
                     /locus_tag="KZX51_RS10260"
                     /old_locus_tag="KZX51_10225"
     CDS             10721..11824
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003223694.1"
                     /locus_tag="KZX51_RS10260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_10225"
                     /product="hypothetical protein"
                     /protein_id="WP_248062591.1"
                     /transl_table=11
                     /translation="MVTETKANLYTMSFLHSELTFQLEEAISLGSIFDFFGTHFVIKRE
                     ASDHALARITVTNNNDYFNDIDFSAGEEVYLRKSASDFFTIPAKRVSLGETVYFQCSKT
                     NTYIAMNSTNGTIVIATPWENVEREELVLIELIRDLVLKNEENHGVVVLHATCSYHDGK
                     ANLIIGPKGAGKSTTLLELVSKLGHQFMSGDKTFLWVKEGQLYASGWPDYPHLGLGTLS
                     KYPEFVGEFGLADEIDAAQETLWSTDHKRAIPPAVFKSMIPHVPAGFVAPVGAFIYPKL
                     EPSEHSVITQLDNHVSLMVPHIERMFGEKGPAKRWNEFVKPGNLDEIDNMIEQCKTVAY
                     ELPAFEITGSGVLTSHNFLDGGVISYE"
     gene            11817..12953
                     /locus_tag="KZX51_RS10265"
                     /old_locus_tag="KZX51_10230"
     CDS             11817..12953
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016777.4"
                     /locus_tag="KZX51_RS10265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_10230"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_248062593.1"
                     /transl_table=11
                     /translation="MSNKGQYEDFFIVDADVHINETPEDLIPYCDLPWRKALESIVDVP
                     RRYLNIPGFAPQFSGNRPFWPGGFDKKTVNTPEQLRQELTELGIDIAIIFPDNLLLIAT
                     FPQREYAAALARAYNAYLVDQWADRLQGLKGLILAAPQDPHDAAREIHKYKDEEGIVGV
                     YLPCGGLHTLWGHEMYNPIFEAAEEAGLPVIFHSVLTLNTAFPFNGLEQFETEFARHAL
                     AHSMSLMFNMLRLIETGVPVRYPDLKMCFIEGGVSWVPYMSMRLDKEYMERRRYVQHLE
                     KPPSHYIKNFYYGTQPIEEPENPSDLAKVIELYEGEDTTMFASDWPHHDFDHPRAIINS
                     GLSKEVKRKILGENALAFFDIDRQGKRLRSRAQKGILR"
     gene            12953..13309
                     /locus_tag="KZX51_RS10270"
                     /old_locus_tag="KZX51_10235"
     CDS             12953..13309
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025178.4"
                     /locus_tag="KZX51_RS10270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_10235"
                     /product="Rieske 2Fe-2S domain-containing protein"
                     /protein_id="WP_145404297.1"
                     /transl_table=11
                     /translation="MRRTFDVAAVDEIPVGKHKVVSLKGRTIGIFNINGSFHALPNICP
                     HQIGPLCEGKVSGTLYRDKKTWELHWTEEGEIVTCPWHGMEFRVRTGECLAYKQVKLRT
                     YTVTPVDGRLLLEL"
     gene            13324..13557
                     /locus_tag="KZX51_RS10275"
                     /old_locus_tag="KZX51_10240"
     CDS             13324..13557
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KZX51_RS10275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KZX51_10240"
                     /product="hypothetical protein"
                     /protein_id="WP_145404296.1"
                     /transl_table=11
                     /translation="MMDDDNNKLQLVMIEAETEYLVSFSIHPEDWIARFDKSLNKSKEW
                     ALNMVALYNNQLASNLESRKGGKDGRDASFGE"
     gene            13529..14692
                     /locus_tag="KZX51_RS10280"
                     /old_locus_tag="KZX51_10245"
     CDS             13529..14692
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_5"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF026257.4"
                     /locus_tag="KZX51_RS10280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_10245"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_248062595.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 1.3e-43, bitscore:
                     144.7, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVMHRSESEAWSALSNEQQLMILCSRIHLCKDHEQDIRLILQRG
                     IALDYFMALCIKHKVLPLVTPHLIRLDNFKAIKLEYKKVMNHAYQGNRIKNELMAEELK
                     LILEQARDKNVELIPLKGAWLIPHVYKDPGLRISNDLDFLVSLEQGQAISEMLQHMGYK
                     PGHYDWASDHVTEVSEEEVLQWSTRSGNLHPHMKRVNNGFAKYIGVDFSYDVDLTRTFI
                     ASGGLQRGACTRELYSVPAKCLGTVDFLIHLAIHLYKEASHERWVRIDQDINLIKFCDV
                     REYILAHVQELEWSEVAARSKELAAEEALYYALYYLKMIFNDPFVDQVQGYLSISGEDI
                     LKRYVAMEGGQESTWQTSFFDRFFSLSNSAEQDNSHGELTPAEQGAP"
     gene            14695..15465
                     /locus_tag="KZX51_RS10285"
                     /old_locus_tag="KZX51_10250"
     CDS             14695..15465
                     /GO_function="GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Metallophos_2"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018131341.1"
                     /locus_tag="KZX51_RS10285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_10250"
                     /product="metallophosphoesterase family protein"
                     /protein_id="WP_248062597.1"
                     /sec_met_domain="Metallophos_2 (E-value: 4.8e-22, bitscore:
                     74.1, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIAILSDIHGNAVALEQVLEHISCKQIDTVLVLGDLIFRGPEPQ
                     KVLDLLRSTSALILKGNTDVWITRGIQKDEVPETDYEIMNLERQWTLDQITEEDVAYLD
                     SLPTELSLSLSETMSLHAFHATPEDLFEVILPSGSAELFREKIMTNQQAAVYAYAHTHY
                     PMLRYMDGKCIINPGGVGYTFDGYTQSSYAIVEEEKGQLRVSIERVSYDIDQVVGMYEK
                     FCYPNAELMKQVLLCGVHPYEVKLKSKGTMSYVI"
     gene            15455..15856
                     /locus_tag="KZX51_RS10290"
                     /old_locus_tag="KZX51_10255"
     CDS             15455..15856
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003223695.1"
                     /locus_tag="KZX51_RS10290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_10255"
                     /product="YjbQ family protein"
                     /protein_id="WP_248062599.1"
                     /transl_table=11
                     /translation="MLYEIKVSSAGYNAHYDITDEVAALLPKLEPAEGLVKVFAAGSTI
                     GLVSMRYEPGTVEDLLDALESVSPKGHSYAHFRTTKDANGFAHVWSSLIGNSLLMPYRN
                     AKLAVSDTHRIVLFDFDLQPAIRTIFISN"
     gene            15877..17043
                     /locus_tag="KZX51_RS10295"
                     /old_locus_tag="KZX51_10260"
     CDS             15877..17043
                     /NRPS_PKS="Domain: Aminotran_5 (8-324). E-value: 1.3e-38.
                     Score: 124.8. Matches aSDomain:
                     nrpspksdomains_KZX51_RS10295_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013307901.1"
                     /locus_tag="KZX51_RS10295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_10260"
                     /product="alanine--glyoxylate aminotransferase family
                     protein"
                     /protein_id="WP_248062601.1"
                     /sec_met_domain="Aminotran_5 (E-value: 4.4e-28, bitscore:
                     93.6, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.9e-07, bitscore:
                     25.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLRMATPGPTYVPQDILLAGAQELVHHRSTQMEEVMERINHSL
                     PILFGTEQKVFTLLSSGTGAMEAAVANCFQEHDKVLVVSNGYFGERFADIAKVYGVQPI
                     EIVCPWGSSVDIAQVEKAYREHPDVKGILVVYSETSTGVTNEIQGLADFFRDKDVLVIV
                     DAISGLLSHELVMDQWGLDVVLAASHKGFMMPPGLAFVCISEKAWQRLEQIEPKTYYFS
                     FKRFRTFYPMSPSSPGVSLIFALQASIEMLMKEGLSACHQRHYWIAQAAQAGLTALGFD
                     LFVTNLQRRSHTVTTAIAPQGLDTSQLLHILSSRYGLSITGGQGEFKGKMIRVGHIGSV
                     DMLDMFSVFGAIELALADMGASFTKGSSIAAIQEVQKRSVYHADFVST"
     aSDomain        15901..16848
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KZX51_RS10295_Aminotran_5.1"
                     /evalue="1.30E-38"
                     /label="KZX51_RS10295_Aminotran_5.1"
                     /locus_tag="KZX51_RS10295"
                     /protein_end="324"
                     /protein_start="8"
                     /score="124.8"
                     /tool="antismash"
                     /translation="PGPTYVPQDILLAGAQELVHHRSTQMEEVMERINHSLPILFGTEQ
                     KVFTLLSSGTGAMEAAVANCFQEHDKVLVVSNGYFGERFADIAKVYGVQPIEIVCPWGS
                     SVDIAQVEKAYREHPDVKGILVVYSETSTGVTNEIQGLADFFRDKDVLVIVDAISGLLS
                     HELVMDQWGLDVVLAASHKGFMMPPGLAFVCISEKAWQRLEQIEPKTYYFSFKRFRTFY
                     PMSPSSPGVSLIFALQASIEMLMKEGLSACHQRHYWIAQAAQAGLTALGFDLFVTNLQR
                     RSHTVTTAIAPQGLDTSQLLHILSSRYGLSITGGQ"
     gene            17021..17287
                     /locus_tag="KZX51_RS10300"
                     /old_locus_tag="KZX51_10265"
     CDS             17021..17287
                     /GO_function="GO:0015035 - protein-disulfide reductase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GST_N_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003223700.1"
                     /locus_tag="KZX51_RS10300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_10265"
                     /product="glutaredoxin domain-containing protein"
                     /protein_id="WP_145404292.1"
                     /sec_met_domain="GST_N_3 (E-value: 2.5e-07, bitscore: 26.5,
                     seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLILYQRETCPYCKPVRERLTELQITYINVNLPRERAERVALIEK
                     MGVPFIPAIEDEGVLIPGKLEDNAHILSYINEHYCKQKDVNKV"
     gene            complement(17533..18549)
                     /gene="adhP"
                     /locus_tag="KZX51_RS10305"
                     /old_locus_tag="KZX51_10270"
     CDS             complement(17533..18549)
                     /EC_number="1.1.1.1"
                     /NRPS_PKS="Domain: PKS_ER (12-333). E-value: 1e-17. Score:
                     56.2. Matches aSDomain:
                     nrpspksdomains_KZX51_RS10305_PKS_ER.1"
                     /codon_start=1
                     /gene="adhP"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007410355.1"
                     /locus_tag="KZX51_RS10305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_10270"
                     /product="alcohol dehydrogenase AdhP"
                     /protein_id="WP_111268338.1"
                     /sec_met_domain="ADH_N (E-value: 2.5e-30, bitscore: 100.0,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 6.8e-31, bitscore:
                     102.4, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAAIVTEDKRVRVEEKQLRPLNHGEALVQMEYCGVCHTDLHVKN
                     ADFGNVTGRVLGHEGIGKVIKLGEGVTSLEIGDRVSIAWLFESCGRCEYCLTGRETLCR
                     QVKNAGYTVDGAMAEQCIVTADYAVKVPDQLDPAAATSVTCAGVTTYKAVKVSNIRPGQ
                     WIGIFGIGGLGNLAVQYAKHVFNAKVIAFDISDEKLELALKVGADHAVNSLKDDPVLKA
                     KQLTNGDGLDATVVTAVAKKPFNQAVDVVKAGGRVVAVGLPTDKMDLDIPRLVLDGIQV
                     IGSLVGTREDLQEAFGFAAEGKVVPIVSKRKIDDINQIFEEMEEGKIQGRMVIDFTT"
     aSDomain        complement(17551..18513)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KZX51_RS10305_PKS_ER.1"
                     /evalue="1.00E-17"
                     /label="KZX51_RS10305_PKS_ER.1"
                     /locus_tag="KZX51_RS10305"
                     /protein_end="333"
                     /protein_start="12"
                     /score="56.2"
                     /tool="antismash"
                     /translation="RVEEKQLRPLNHGEALVQMEYCGVCHTDLHVKNADFGNVTGRVLG
                     HEGIGKVIKLGEGVTSLEIGDRVSIAWLFESCGRCEYCLTGRETLCRQVKNAGYTVDGA
                     MAEQCIVTADYAVKVPDQLDPAAATSVTCAGVTTYKAVKVSNIRPGQWIGIFGIGGLGN
                     LAVQYAKHVFNAKVIAFDISDEKLELALKVGADHAVNSLKDDPVLKAKQLTNGDGLDAT
                     VVTAVAKKPFNQAVDVVKAGGRVVAVGLPTDKMDLDIPRLVLDGIQVIGSLVGTREDLQ
                     EAFGFAAEGKVVPIVSKRKIDDINQIFEEMEEGKIQGRMV"
     gene            19011..20570
                     /locus_tag="KZX51_RS10310"
                     /old_locus_tag="KZX51_10275"
     CDS             19011..20570
                     /GO_function="GO:0016811 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds, in linear amides
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009590010.1"
                     /locus_tag="KZX51_RS10310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_10275"
                     /product="acetamidase/formamidase family protein"
                     /protein_id="WP_248062603.1"
                     /transl_table=11
                     /translation="MFINRTIRKFGISAGIIGMFTFALPSVGFSMPLQPTTIDKVEGDY
                     YVTSAIENIRWGSLPNRDSSPILTVPSGSAVTFDTVSHEGLIEDQGRNPVEYFGKFGIS
                     PDGVLDDAKAIAASAIKHDYVKDGPHIITGPVAVEGAMPGDVLKVEVLSLQTRVPYGVI
                     SNRHGKGALPNEFPENTGPQEGASATKPELYNNVSIFTPIEEINGNWYGLLPTKAGKKV
                     RFPINPFLGVMGVAPNTSEVVSSIPPIETGGNMDINELGVGATIYYPIQVKGGLFYTGD
                     PHFAQGDGEVALTALEASLRGTVRLTVLKEGDPSLPHRGEFTQPFAETEDYWIPIGLDP
                     DLDEAMKESVRESIQFLSDKLDMDRSVAYAYLSAATDYEVSQVVDRTKGVHGLIRKTDF
                     LEYVDIIMNVGGTLIKPVVHNNEFYVPIRTISELLGGTVVWDNKSRTTQIKLGTKNISA
                     QIGSDVYSINDKLVFNSKVPKLLNGETVVPVSVINEILGAYVNWTTIDKTLTANVSLSK
                     KQ"
     gene            complement(20741..21187)
                     /locus_tag="KZX51_RS10315"
                     /old_locus_tag="KZX51_10280"
     CDS             complement(20741..21187)
                     /EC_number="1.11.1.-"
                     /GO_function="GO:0004601 - peroxidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018758056.1"
                     /locus_tag="KZX51_RS10315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KZX51_10280"
                     /product="OsmC family protein"
                     /protein_id="WP_248062605.1"
                     /transl_table=11
                     /translation="MSALQTFKASAHLQNGVRVKVASRNFEFIIDEPKSLGGTDTGMNP
                     VEALLASLGACQSIVARVYAPKFGVNLNDFFVDVEGDIDLDGFFDKSEVRPGYSDIRYT
                     FRIKTDSPQEQVEAFVQFLESKCPVGDTLAHPVNLKLDRIIIEN"
     misc_feature    complement(21707..21721)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.12"
                     /tool="antismash"
ORIGIN
        1 aacctttgaa ccaaccatcg tttacgggca acaagtagat cagatgcaac ggcgtgaaga
       61 tgggattttt gtgctcacta ctcaaacagg agagctgcat tatacaagaa caatcatatt
      121 atgtgcggga aggggcataa ctcaggtaca gaagcttgat attgaaggcg ctaatcgata
      181 tgaactgacc aatttgcatt acacgattac tgatctgtca agattcgctg gaaagcgtgt
      241 tctaatctca ggtggaggaa actcggccgt cgattgggcg aatgagatca ctccaatcgc
      301 ttccgaagtg accgtgattc acagacagca tcagttcagt gcacatgagt tacctgttgc
      361 gcagatgaaa gcgatggttc gggtaatgac cccctatttc ctttctcgtt tatacggggc
      421 gggagagcat atagagcggg tagaggttac tcaggtagag aatggagaga ttacgcagct
      481 agacatcgac gaaattgttg tatgtcatgg gtatgatcgt gatttcggtc agcttgtaca
      541 atggggatta aagcaggatg attatggagt aagggttgat gcacgtatgc ggacaagtat
      601 tcccgggata tttggtgcag gtgactttat tacttatgga agcaagttca gactgatcgc
      661 aggcgctttt tctgacgcag tccttgcagt taacagtgca aaaacatatt tggacccttc
      721 tgccccgaat atggcaggtg tttcctctca caatgcccgt ttttttgata aaaacaaagc
      781 gtttaacaag ctgtagtaag tacaggcgat gattaaattc attatggaag ctgacgtcgg
      841 tgatatgctg acgccagctt ttttaatttt attgtgacct tttttgatca aaagtgaata
      901 tattcttcaa ttctcttgtg tgcttactag ggcgtgtctg agaattctga aggaagccaa
      961 ttttgctgaa ttttcgttcc aagtcaggaa gttttctgca ggtgtgccgg ggtgcgtcaa
     1021 ggaaaagtga taaagcaggg ggcgaaaagg cggtaaaaga tgcacttcag taggtatcaa
     1081 gatacgcccc aattcgggat agaggcgttt aggaggaaaa tgcaaaaaag ctgtaaacaa
     1141 agcgaattat acctgtttgt accgaacctt tgcttctgta caggaatatt attattaagt
     1201 ctttagtaaa gcattgctgc tggagtaaga ggttcacaga aggagggaga tgggagattg
     1261 acaattttgt caacgggacc gattgagaat aatgccgttt ccggcgttag accgacaaag
     1321 caggtaacta ttagaattgt gagtcgggta gctgctgtag tcgtatcagt gcaggggtat
     1381 gtgctagaca caacaagaac gttgtatgtg agtgaactga taagtgttgc tcctaatgag
     1441 gcattgactc gtaattattt tgcggattta gatgcctttg agtttctttt tgaaataaat
     1501 gaggcaaatg tgggagatgt cgaaatttca gtgtggggaa aaaaggcatc aggagaattg
     1561 gtagattcac atcgggtagt ggagcacgaa aaaacaataa ctaattctta aaggtactat
     1621 tcttcaacga agggagcaaa gcgatgagtt ttttatcgac agggccaatt gaaaataacg
     1681 ctgttagtgg tgtaagaccg acgcaatccg taacggttag aattgataat cgaagtgatg
     1741 ctacagtctc gactgtacta attcaaggat attatatgag tggcggaaca aggattcaat
     1801 atgtcagtca aacttttgat attgcaccaa atcaagtgat aacaaacaat tactttgcca
     1861 atttagatgc ctttgaattc accttcacta caacagctca gtttaatgat cctgtccaaa
     1921 tatctgtgtg ggggaagagc agtactggct ctctagtgac agcccatcgt ttagtttctt
     1981 cggaactact gggtgaaatt ctgggtacaa caggggcaac tggggctacg ggagcggctg
     2041 gtgcaacagg cccgacggga gcgacaggcg ttgctggtgc aacaggtccg acgggagcga
     2101 caggcgttgc tggtgcaaca ggtccgacgg gagcgacagg cgttgctggt gcaacaggcc
     2161 cgacgggagc gacaggcgtt gctggtgcaa caggcccgac gggagcgacg ggcgttgctg
     2221 gtgcaacagg cccgacggga gcgacaggcg ttgctggtgc aacaggcccg acgggagcga
     2281 caggcgttgc tggtgcaaca ggtccgacgg gagcgacagg cgttgctggt gcaacaggcc
     2341 cgacgggagc gacgggcgtt gctggtgcaa caggcccgac gggagcgaca ggcgttgctg
     2401 gtgcaacagg cccgacggga gcgacaggcg ttgctggtgc aacaggtccg acgggagcga
     2461 caggcgttgc tggtgcaaca ggtccgacag gagcgacagg tggtaccggc gcgacaggcg
     2521 tgacaggagc aacaggcgtg gcaggtactg gagcgattat tccttatgca tctggtcttc
     2581 cggcttcact aactacggtt ttaggcggag ttttgaatac ttccagcttg gttggttttg
     2641 ggagcagtac aactggaata acgatcagtg gaggagttat tgacctcaca ggctcaccag
     2701 gcacgttgct taactttgct ttttctgcac cgcgtgctgg aacgattact tcgcttgcgg
     2761 cttattttag tacaacagca gcacttagct tggtcggaac tacaataact attactgcac
     2821 aattattccg atccactaca cctgataata gctttacggc cgtgccggga gccgttgtaa
     2881 ccttggcacc agcgttgact ggcattctag cattaggcac aatctccagt ggattgacca
     2941 cagggctgag tatttcagta gctgctagtg accgattgct tatggtcttc tcagcaacag
     3001 ttacagccgg aatcgatgtg gctaccactg ttccaggata tgcgagcgcg ggtcttagca
     3061 tcacttaatg gaaatattaa atagttccaa tccagaaaaa aaactcttaa atattagagc
     3121 agtaggctct tgtctacaat gtataaaata gggattaatt tgcattaatg tatgatcttg
     3181 aaggattttt tttataaggc agggcacgtt aatctcattg tcgataagaa agtaaccgcc
     3241 agaagtttta gaactttagg cggttacttt ctcactgtac acatattgtt ttctgttggg
     3301 tcggcatggt aaggattgct gcttcaaaag cattggctgg tcgagccata ttgtgccctg
     3361 atccttgagc aacaattatg cgcaaaatgg tgggacagcg ttaagagatc ctgctgcatt
     3421 tcgcccattt cagttccatt tttggtccca tcctgtgaga aataacgatt gttcccaatg
     3481 aatggtaata acgattaatc tgggttatgt gaaagcatct ctagcgcttg ccttgcatga
     3541 tatgcagcaa gattcttggc aaactgccga tcggggaagt gtctgtgaag aagctttagt
     3601 ccccctgagg tcaacgataa atgatgacat aaacgataga atgacagccg tgcagaatca
     3661 agattttctt gttcaaaata acgatagtat tcgccgaatc gaagcttcag aaagctgtgc
     3721 tcatgctcaa ggtcaaagaa ccctgcacct tcaatatcaa tcaggtacgg ctgcatttta
     3781 tgatctatta taatgtgatt gggtccgagc tcatcatgga tgacatgatg atggcaaaat
     3841 atacataagc aggggctggg cgactcaaca tgtttgagtg tacccagccc cttatttgcg
     3901 ctgaaattaa ctgcttgtta cggtaagtct ggctgttcat atctcacgat tgatattatc
     3961 tgcaccttta gctccctgtc gttcgagcca agtaaccaag tcggtgaaac catttcgctt
     4021 ggctgtgtcc aatggtgtcg atccgtccca ggcagctgcc caattcagtt cagcaccttg
     4081 ctggagaagg tatgcggctg cttcttgctg gcccccatga caagcacacc agaaagatat
     4141 atttactgta tctgttggag ccgaggagct acctgaagcc cagggataat attccggtag
     4201 tgtctttcct ttaaaatggt ttttgatggc atcgatcttt ccgagtgcgg ctgcatgcca
     4261 aagtgcggta agagctccgc gttcaaccag acgccttgcg gtattccact gtgcaaatgc
     4321 aacggcatcg tccagcggtg ttcctccggc aattacggcc ccggatgctt caatgtcagc
     4381 accagcatcg atcagagcat ccagtgcttg tacatcatca cagcttgcag cccaatgcaa
     4441 gggggtctcg tgatttgcac cgagcatggg ggcgttaact tcagcaccgt atccggtcaa
     4501 catacgaatc gtctttgtta cattgggaaa atgacccggc cagtctgtgg ctatatgcag
     4561 cagcgtccgg gaaaccgttg agcaggcccc tttgttctga gggttccgtt ccagaattct
     4621 tgtttttgcc aacccggagt gttccaataa aagctgttcc aaagaggaag tctcacctgt
     4681 ctgaatggct cgtgtcactc tttgagctac agcttcatct tcatacatcc attccatgtc
     4741 ccagtctcct ttgatttcgc tatcatttca ctatacatga aagagtccaa tgaagagcaa
     4801 gaaagcatct atcatttgtt gacagcaagc atgaagaatc gtgttacagg ttttccaaag
     4861 gatagaccgt tttttacaat ttatttacaa aaacgcttgc tttcaacttt tttttatttt
     4921 atgattactg aaaaataaat ctaaaatttt acatgtgtgg tatgttatgt tcgtaaaatg
     4981 agtgacatgg aggtaagcac atggaagaaa tgtctttgtt gaaaaagatc atgaggtcag
     5041 tagcacataa ggacaacatg gcaatggaca gtaaagaaga catagacacc atgttaggca
     5101 caattagcaa acataagctg gagccctatg taaacgttat gcaaggaaac agcctcccag
     5161 aaatcgaaaa tcgtctaaca aggattaaag aacaatacaa acggcatatt acgttccttg
     5221 agaagctgag aaacacaacg gagaaaccca tagttgttgt caaaggattc agtaattatc
     5281 atgcgtcaga aggacgggtg cttctaagag aaacttctga tctggatatt ttgtcgcctc
     5341 atcctgtcag gctgagggag gagttgttag cctctggttt catcgaaaag aaaacagaga
     5401 cggagcatga gctttctgag ctggagcagg acggaatttt gattgatatt cataaatttg
     5461 tacccgttgc gagctatccg gcagatatag aggaaatatg cgaaagcaac cattacacga
     5521 caacggaagg aatgtttttc tcaggagaaa ttagttataa cgatataaaa gagcactcca
     5581 ttgagatcat cgataatgtg cttgtgccca acgtgaacat gtctcttctt atctcttgtg
     5641 tctctatgtt tagagattat attacatcac tagaggatgt ccctaatctg aaattaatca
     5701 atctcgtaga gatctttatt ttaatgcatg aacctacatt tgatccagcg gagtttattc
     5761 aaatggttcg taaatataag gcagaacaca gtatcgcatt tgtaaatcat cttttgttag
     5821 acatttatga tgagcaactt gttgatgttg gagacaatat aaagcgcttt ccgcaaatac
     5881 tgttttggag tgaaaagtgg attattcctc tggacgttgt aaagtctgtt tgtaataccc
     5941 gtttcgaaaa cgttctcgaa ctattgggag ccgaacaaaa atggctggat gagcatcatt
     6001 cgctaaggat gacggcagca tctcgctccc cgagatatca tacatttaat gatgagtttg
     6061 acaaacaaat caccttggcg gtgaaatgga cagaccatct tcatatttcc ctggaaatga
     6121 caccctttga tcagctgcat gatcatgata tatttcgatt caattttggc aagtcatgga
     6181 acaaaatttt tctttttggc tcggatgaat gggggaccag cttgtttgga gaaacgttca
     6241 atgattatgc cggatttgtt cacaaggaag gagaacaggt gttaaaaata gatattctca
     6301 tcccacctga gaagctggaa acgtatctgc ttcataaaca tcaactaggg gtcaatattt
     6361 atcttgaaaa acacgaaaat aataaacaat tcagtatgta cattcctttg tttatttcta
     6421 aagtatcggc tggcatgaaa tccataacct gaaagagagg gtgagtgcat tgaactcgac
     6481 cacattaagt acgcctgcgg aaaagatact atctgtcttg caaacgaacg gatacaagca
     6541 ttttagtggt gttccgtgct ctcttttaaa aggtcttttt gctttattgg agcaaagcga
     6601 tgcttctact atgcgttaca tacctgcagt tagggaggat gcagccatcg gggttgcttc
     6661 aggcttcgcc attgctggac acaagagtgt ggtattaatg caaaattcag gacttggcta
     6721 cagtttgaac gtgctgacct ctttcaacat gatttatgat ctgcccgtaa tgcttctgat
     6781 cagctggaga ggtgcatatg agcacgatgc agtagagcat gacatcatcg gggacagatt
     6841 aacccctctt ctggatgccg ttgacattcc atatatcgaa cttgaaacac acaaagtaga
     6901 acaaagcgtt attaaagcaa ttgaacaaat ggaatgtact caaaagcccg ttgcgatact
     6961 cattaaagat gaagtataag gagaggaaac ggattgagaa aagacgaagc gatacagctg
     7021 atactggacc aatttcccat tgcctacatt gtcagtacct gcgggcatat cactagagat
     7081 ttgtataata agtgtgatcg agaagagcat ttttatatgg tcggttcgat gggcatggct
     7141 gctcctgtag ctcttgggct tgcactcgcg aatgagcacc agcagattgt tattctggac
     7201 ggtgatggct cctttctcat gaatttaggg gctgctgcaa tgattggaca acaacagcct
     7261 cgtaatctga tacatgtggt attggataat ggtatgcatg agagtacagg tggacagcgc
     7321 acaatcggca tggagaatat gactacagcg gtactttcca tgggatacaa ggcaggcttg
     7381 aaaatggata aacatgaaga ttggcagcag ttgcaccacc atgaaggccc ggttttgatt
     7441 catatcaagg ttgatcctcg aactgaaaag gtcggaaagc gagtagaatg gacaccgcag
     7501 cagattctct ctcgtttttc gaaagcgata aggggtgaaa cgtgtgagct ttcagctaat
     7561 tgactgtact ttgcgtgacg gcggtaatct gaatcaatgg cgtttcagcg atgttgctat
     7621 tggacagatc ataaggggtc tggatcaagc tcgaaccgac tatattgaat tggggtattt
     7681 aggtggttca gggagtcatt cgcccggaga agtgggtaaa acgtttgact gtacttctga
     7741 atttctagat gagctgcccc aaacttttca cgctagaaaa gcaattatga ttgttccatc
     7801 cgtatgcagt caggaacagc tatctaagct tcatacgagt caggtttcgc tggttcgtgt
     7861 tgcctcttat ccccaagata cagcatacgc tatgtcatat attgcagcat tgaaggatcg
     7921 aggatttcaa gtggccatga atctaatggc tgcaagttat gctgagcctg accaggttgc
     7981 ccgggttgca gtggaagccg aacgacatgg tgcagatata ttttatattg cggattcata
     8041 tggcagcatg acacccggag atgttcgtca atatgttgag gctctgaaac aatctacgga
     8101 ttgcgaggtt ggttttcacg gacataacaa tctgggtctg gcatttgtca atgtattgga
     8161 agccatgcgt tcaggtgcaa gctttataga tacttctctc tgtggaatgg ccaggggggc
     8221 aggcaatctg ccaacggaac aattcataag tgcattgagt cattgggaac aatttgacac
     8281 cagttatgaa gtgctgccag tggttgaaac agcggactac gttctcaatc atgtactgga
     8341 aaagccgatg agaatagctg ctcccgagat tatatgtgga ctccataaca ttcattatta
     8401 ctactatgat aaaatacttg attctcgttc aggcatgcag atgcaatctg catggaacat
     8461 tgcacaatcc cttggaaagt tgcgtccacc caaagtacat gtttcctatg tgaataaagc
     8521 cattgaattg acaggaggaa tgaaaagtga aagctaaaca attgagagat ttgctgaatt
     8581 caaacaaatt gattcgggtt atgggtgcac ataacggtct tagcgcaaag cttgcagagc
     8641 aagctggttt cgatgcgatc tgggcaagtg gtctggaaat ttcggctacc cattctgttc
     8701 ctgatgctaa tattttgacg atgacggaaa atttgcaggc ggcaatctcc atgaatcagg
     8761 ccacttcaat tccgattata tgtgactgtg attccgggta cggcaacgtc aataacgtta
     8821 ttcgcatggt gaaggaatat gaaagaaatg gcatggctgg catatgcatt gaagataagc
     8881 aattcccgaa attaaacagt tttatcgatg gtcctcagaa gctaacgccg atagatgaat
     8941 ttgcaggtaa aatacgtgct gccaaagata cacaatctga tcctgacttt gttgtgattg
     9001 ctagaatcga ggcgttgatt gcagggcaag gtttgcagga agccttgaat cgggcatatg
     9061 cctatgaaga ggcaggtgct gatgccatcc tgattcattc caaacagaag cagcctaatg
     9121 aaattgtctc gtttgtggag atgtataaag gagctgctcc aattgttatc gttccgacga
     9181 cttatcctac cctggatgtg gaacaaatcc gcgatttcgg aattcagatg gtgatttatg
     9241 cgaaccatgg tttacgcagc tcgattaaag cgatgaaaga aacatttgat cgaatcctta
     9301 gggagggcca tacggcaggg gttgaacttg atatttcgac tatgcaggag gtgttcgagc
     9361 tgcaaggtat gtttgagatg agacagcaag aagataaata tagcacaggc tcagtgattc
     9421 tgaataacta gttgtgggga gagagcagaa tgaagcttca ttgtaacgat tgtgatcagc
     9481 gctttgaact aagcgagttc agatatgctt gcagctgtgg tggacttttg gaggttgagc
     9541 aggatttcag ccgcttggat tcagacgaat tgaagcgaag ctttaatcaa cgtttatccg
     9601 atcgaatgag tccctatgca agtggagtat ggcgctataa agaactgata tttcccgagc
     9661 tggaagagag gcatttggta acgaagtatg aggggaatac ggggctgtac caggccgaca
     9721 aggtgactca gtatacaggg ttacggaaaa tctggctgaa atgccagagt gaaaatccga
     9781 gcggttcctt caaagataat ggcatggttg ttgctgtctc tcatggcaag tcgctggggc
     9841 ttgataaatt tacttgcacc tcgaccggca atacgtcttc ctcactggcg atgtacagct
     9901 cgcttataga ccgtcaagct tacgtttttg tacctaatca aaatatttca cttaacaagg
     9961 tattacaaac ggttgcgtat ggagcaaaag tgattgcctt tgacgggacc tatgatcaag
    10021 ggattgcgtt tttggagaag catcatccgg aactcggcct gtacatctgc aattcgatca
    10081 atccatttcg tattgaaggt cagaagagta ttatttatga aattgcccag taccttcagt
    10141 gggagttgcc cgattggatt gttgtcccgg gaggtgcatt gagcaatgtc tcggcattgg
    10201 gcaaaggact tgctgatctg tatgcgctcg gatttattcg taagctgccc cgggtagcgc
    10261 ttgttcaggc tgaaggagcc agtcctttcc acaagatgat gagcaataaa caagatacgc
    10321 tccagccgga acctcatccc aacaccattg cttccgcact taacattggt catcctccaa
    10381 gctggaaaaa ggcacgtcag accctgagga ataccgatgg aattaccgtt tccgtaacag
    10441 atgaggagat tcttaatgct aaagccatca ttgatcaaag cgggatcgga tgtgaacctg
    10501 catcagcatc taccgttgct ggacttaaaa agctacatgc ttcaggtgaa attcatgccg
    10561 atgaaacagc tgtctgtatt ctcactggac atctcctgaa agataccgaa gtgttgagaa
    10621 aatatcattt ggaaaatgcc aggggtgcat tgtttgcgaa tcctatacgt caatcagcat
    10681 tggatataga tcagattatt actttataaa agaggtgtat atggtgacag aaacaaaagc
    10741 aaatctctat acgatgtctt ttcttcactc agagcttact tttcaactgg aagaagcaat
    10801 atctctgggc agcatctttg atttttttgg tacacatttt gttataaaaa gagaagcttc
    10861 cgaccatgct ctggcccgca taacggttac gaataataat gattatttca acgatattga
    10921 tttctctgct ggggaagagg tttatcttcg caaaagtgca tccgattttt tcaccattcc
    10981 tgccaaacgt gtgagcttag gagaaacggt ctatttccaa tgctccaaga ccaatacgta
    11041 cattgctatg aattccacta acgggacaat tgtgatcgcc acaccatggg aaaatgtgga
    11101 aagagaagag cttgtcctga tcgagcttat tcgtgatctg gtgctcaaaa acgaagaaaa
    11161 tcacggagtc gtcgtattgc atgcgacctg ttcttatcat gatggcaaag ccaatttaat
    11221 tatcggacct aaaggggcgg gtaaatccac caccctgttg gaactggtaa gcaagctcgg
    11281 gcatcaattt atgagtggag acaaaacctt cttatgggta aaggaaggac agctctatgc
    11341 ctcgggctgg ccggattatc ctcatctggg attaggaact ttatccaagt accctgaatt
    11401 tgtgggggaa ttcgggttag cggatgagat tgatgcagcc caggaaacat tgtggtccac
    11461 cgatcataaa agagcaatcc cgcctgccgt gttcaagtcg atgattcctc atgtgcctgc
    11521 tggttttgtg gctcctgtag gtgcttttat ctatcccaag cttgagcctt ctgaacatag
    11581 tgtaattaca cagctggaca atcatgtctc gcttatggtt cctcatatcg aaagaatgtt
    11641 tggtgagaag gggccggcga aacgctggaa tgagtttgtg aaacctggaa atttggatga
    11701 gatcgacaac atgattgagc aatgtaaaac ggttgcctat gaactgcctg catttgagat
    11761 tacaggctct ggcgtcttga caagtcacaa ctttttagat ggaggtgtca tttcttatga
    11821 gtaataaggg gcagtacgag gattttttca ttgtggatgc tgacgtgcat atcaatgaaa
    11881 cgcctgagga cctgattcct tactgtgact tgccttggag aaaagcactt gaatcgatcg
    11941 tggatgttcc tcgtcgttat ctgaacattc caggctttgc tcctcaattt tcgggaaatc
    12001 gcccattctg gcctggtggt ttcgataaaa aaacggtgaa tacccccgag cagcttcgtc
    12061 aggaactgac ggagcttggc atagatatag ctattatttt cccggataat ctgttattga
    12121 tagctacatt tcctcagcgg gaatatgcag cagccttagc gagggcgtac aatgcgtacc
    12181 ttgtggacca atgggctgac cgcctgcaag ggctgaaagg tttgattttg gcggcccctc
    12241 aagacccgca tgatgctgct agagagattc ataaatacaa agatgaagag gggattgtcg
    12301 gggtatatct gccttgcggc ggtctgcata cgttatgggg acacgagatg tataatccta
    12361 tttttgaagc ggcagaagag gcaggattac ccgtcatttt tcattctgtg ctcacattaa
    12421 acaccgcatt tccattcaat ggattggagc aattcgagac tgaatttgcc aggcatgcac
    12481 tggctcactc catgtcatta atgtttaaca tgctgcggct gattgaaaca ggggttcctg
    12541 tccggtaccc ggacttgaag atgtgcttta tcgagggggg agtctcctgg gtaccttata
    12601 tgtcgatgcg gctggataaa gaatacatgg aacgacgcag gtatgtgcag catcttgaaa
    12661 aaccgccaag tcattatatc aaaaattttt attatggaac ccagccaatt gaagagcctg
    12721 agaatccaag cgatcttgct aaagtgatcg aactgtatga aggagaagac acaacgatgt
    12781 ttgcatcgga ttggcctcat catgactttg accatcctcg ggcgataatc aattctggat
    12841 taagcaaaga ggttaaacgc aaaattttag gtgaaaatgc actggctttc tttgatatag
    12901 accggcaggg gaaacgtctt cgttcaagag ctcaaaaggg gattctacgc taatgagacg
    12961 cacatttgat gttgcggccg tagatgaaat tcctgttgga aaacataagg tcgttagcct
    13021 taaagggcgt acgataggca ttttcaatat aaatgggtcg tttcatgcgc tacccaatat
    13081 ctgtcctcat cagattgggc cattgtgtga agggaaagta tccgggacgc tgtacaggga
    13141 taaaaaaacg tgggaattgc attggacaga agagggggaa attgtaacct gtccttggca
    13201 tggtatggaa tttcgagtgc ggaccggtga atgtctggct tataagcaag tgaagctccg
    13261 tacctatacg gtgaccccag tggatggtag gctcctgttg gagctgtaag tgagcgtgac
    13321 ggtgtgatgg atgacgataa taacaagttg cagcttgtga tgattgaagc ggagacggag
    13381 tatctggttt ctttttcgat tcacccggag gactggattg caaggtttga taaatcttta
    13441 aacaagtcaa aagaatgggc cttgaacatg gttgcgttat ataacaacca gttagcgagc
    13501 aacttggaaa gcaggaaggg aggaaaggat ggacgtgatg catcgttcgg agagtgaagc
    13561 gtggtcggca ttgtcgaatg aacaacagtt gatgattttg tgttcccgca tccatctgtg
    13621 caaggatcac gaacaggata tacgtttgat tttacagcgt ggcattgcat tggattattt
    13681 tatggcactt tgtatcaaac ataaggtgct gcctctcgta acccctcacc taatcaggct
    13741 ggacaacttc aaagcaatca agctggaata caagaaggtc atgaatcatg catatcaggg
    13801 aaatagaatc aaaaacgagc ttatggccga ggaattaaaa ctgattttag aacaagccag
    13861 agataagaat gttgagctta tcccgttaaa aggagcgtgg ctcattcctc atgtgtacaa
    13921 ggacccgggc ctgcgtatat cgaatgacct ggactttttg gtttcattgg agcagggtca
    13981 ggccatatca gagatgctac agcatatggg gtacaagcca ggacattatg actgggcttc
    14041 agatcatgtt actgaagtga gtgaggaaga ggtgctccag tggagcacgc gttcagggaa
    14101 cctgcatcca catatgaaac gagtgaataa cggctttgcc aagtacattg gcgttgactt
    14161 ctcttacgat gtggacctga ccagaacatt tattgcatcg ggtgggctgc agagaggagc
    14221 atgtacaaga gagttgtata gtgttccggc gaaatgtctg ggaaccgtcg attttctcat
    14281 acatctggcg atccatctct ataaggaagc tagccatgaa agatgggttc gtattgatca
    14341 ggatattaat ttaattaaat tttgtgatgt tcgtgaatat attttggcac atgtgcagga
    14401 actggaatgg tctgaagtgg ctgctcgatc taaggagctg gctgctgaag aagcgctgta
    14461 ttacgccctg tattatctga agatgatatt taatgatccc tttgtggatc aggtacaggg
    14521 atatttgtcg atctcgggag aggatatttt gaagcggtat gtggctatgg aaggtggcca
    14581 agagtcaacc tggcagacat ccttcttcga ccgattcttt agtttgagca attctgctga
    14641 gcaggataac agccatggcg aattgacacc tgcagaacag ggtgcaccat gacgatgaaa
    14701 atagcgattc tctccgatat tcacggcaat gcagtggcgc tggagcaagt gcttgagcat
    14761 atttcatgta aacaaatcga tactgtgctt gtattagggg atttgatttt tcgtggtccc
    14821 gagcctcaaa aagtacttga tttgctgcgc agtacatcag ccctgatcct gaaaggcaat
    14881 acagatgtgt ggattacacg gggcattcag aaagatgagg ttccggaaac ggactacgag
    14941 atcatgaatc tcgaaaggca gtggacgttg gatcagatca cagaggagga tgtagcctat
    15001 ctggattctt tgccgacgga gctttccctc agtttatccg aaacgatgtc actgcatgct
    15061 ttccatgcaa caccagaaga tctgtttgaa gttattttgc cttccgggtc tgctgaactg
    15121 tttcgcgaga aaattatgac gaatcagcag gcagctgtat atgcctatgc gcatacgcat
    15181 tatcccatgc tgagatatat ggatggcaaa tgtattatta atccgggtgg agttggatac
    15241 acttttgacg gatataccca gtcttcttat gccatcgttg aagaagagaa gggacagttg
    15301 cgagttagta tagagcgtgt aagttatgat atagaccagg tggttggcat gtatgagaag
    15361 ttctgttatc ccaacgcgga gctgatgaag caggtgctcc tttgtggtgt tcatccctat
    15421 gaagtcaaac tgaaaagtaa aggaacgatg agctatgtta tatgagatta aagtgtcatc
    15481 tgccggatat aacgctcatt atgacattac agatgaagtg gctgcgttgc tgccaaagct
    15541 tgaacctgcc gagggactgg tcaaagtatt cgctgccgga agtaccattg gtctggtaag
    15601 tatgcgttat gaacctggaa cagtagagga tttattggat gctttggaga gtgtatctcc
    15661 caaagggcac tcgtatgctc actttcgtac gaccaaagat gctaatggct ttgctcatgt
    15721 ctggtcatcg ttaatcggca acagtctgct gatgccatac cgcaatgcca agctcgctgt
    15781 ttcagataca catcggatcg tgttgtttga ttttgattta cagcctgcta tacgaacgat
    15841 ttttatcagt aactaatcga agggagctga tgttgtatga aaaaactgcg tatggctact
    15901 ccgggaccaa cttatgttcc ccaagacatc ctgcttgccg gggctcagga actggtccac
    15961 catcgctcaa cccaaatgga agaggttatg gagcgtatta atcattccct cccgattctt
    16021 ttcggtaccg aacagaaggt gttcaccttg ctctcttccg gtacaggtgc aatggaagcg
    16081 gcggttgcca attgttttca agagcacgat aaagtattgg tggtatctaa cggttatttc
    16141 ggagaacgtt ttgcagatat tgccaaggtt tatggtgtac aaccgatcga gatcgtgtgc
    16201 ccttggggaa gctccgtgga tattgcacaa gtagaaaagg catatcggga gcatcctgac
    16261 gtgaagggaa ttcttgtagt gtatagcgag acttctaccg gagttaccaa cgaaattcaa
    16321 ggccttgcag atttttttcg agacaaggac gtgcttgtca ttgtagatgc catcagcggt
    16381 ttgctatcac atgaactggt tatggatcag tgggggctgg acgtggtttt ggccgcatca
    16441 cacaaaggat ttatgatgcc tccgggcctt gcttttgtat gcatttcgga gaaagcgtgg
    16501 caacggctgg agcagatcga acccaaaacg tattatttct cgttcaagag attcagaaca
    16561 ttttatccca tgtctccttc aagtccgggt gtatcgctca tttttgcttt gcaggcatcc
    16621 attgagatgt tgatgaaaga ggggctaagc gcctgccatc aacgtcatta ttggattgct
    16681 caggcagcac aggcaggact cacggcttta ggttttgatc ttttcgttac gaatcttcag
    16741 cggcgcagtc acaccgtgac aacagcaatt gctccgcagg gattggatac ttcgcaattg
    16801 ctgcatattt taagttcccg atacgggttg agcattactg gaggacaagg ggagtttaag
    16861 gggaaaatga ttcgtgttgg acatattggt tctgtcgata tgttggacat gttttccgta
    16921 ttcggagcca ttgagcttgc tctagcagat atgggagcat cttttactaa agggtccagt
    16981 attgcggcca tccaagaggt tcagaaaagg agtgtatatc atgctgattt tgtatcaacg
    17041 tgaaacgtgt ccttattgta aacctgttcg tgaacgcttg acagagcttc agattaccta
    17101 catcaatgta aatcttccca gagaacgtgc cgagcgtgta gctttgattg aaaaaatggg
    17161 tgttcccttt attccggcga ttgaagatga gggtgtgctg attccgggca agctcgaaga
    17221 caacgctcat attctctcct acattaatga gcactattgc aagcaaaagg acgtaaacaa
    17281 agtataatgg tgagcagtgt gccggcaaag ctttaaagac agatgcaacg attaattcaa
    17341 atagccttct cctggaggct attgttcaac aagtcccagc gtaaatatat atcactccac
    17401 gcgatctatt cactgatgca tacctgtttt ctattgtgca ggcgtggtga ggatttataa
    17461 aaaccataaa agaacataaa taaaacaggc tacgatgtca tcatcatagc ctgtcagttt
    17521 gtgtaattcg cattaagttg taaaatcaat caccatgcgg ccctgaattt taccttcttc
    17581 catctcttcg aagatctggt tgatatcatc aattttacgc ttgctcacaa tcggtaccac
    17641 tttgccttcg gccgcaaagc caaaggcctc ctgcagatcc tctcgggtgc ccaccaagga
    17701 gccaatcacc tgtatgccgt ccagaaccag acgaggaata tcgagatcca ttttgtcagt
    17761 aggcaatcct acagcaacta cccggccacc tgctttgaca acatctacgg cttgattaaa
    17821 aggttttttg gcaacggcgg tgactacagt tgcatcaaga ccatctccgt tggttagctg
    17881 tttggctttc agcactggat catcctttag actattcacg gcatggtctg cacccacctt
    17941 cagtgcaagc tcaagcttct catcgctgat gtcaaaagca atcaccttgg cattgaacac
    18001 atgtttggca tattgcacag ccagatttcc caaaccgccg atgccaaaaa ttccaatcca
    18061 ctgaccaggg cggatattac ttacttttac cgctttataa gtggtcaccc cggcacaggt
    18121 tacgctcgtt gctgcagcgg gatcaagctg gtcgggtact ttgaccgcat aatctgcggt
    18181 aacgatgcat tgttctgcca tcgcaccatc cactgtgtag cccgcgtttt tgacttgacg
    18241 acacagtgtt tctcgccccg tcaaacaata ttcgcagcga ccgcagctct caaacagcca
    18301 ggctatactg actcgatcac caatctctag acttgtcacg ccttccccta acttaatgac
    18361 tttgccaatc ccttcatgcc caagcaccct gcctgtaaca ttaccgaaat cggcattttt
    18421 cacatgtaaa tctgtgtggc acacgccgca atattccatc tgtacgagtg cttctccatg
    18481 attgagtggg cgcagctgtt tttcctctac acgaaccctt ttatcctctg tgacgatggc
    18541 tgccttcatg tgggattctc ctttaatagc gaatggcatc aatttattat tgggtccaga
    18601 atgtcccaac catctcatag gatttgaagc tgattatgaa aatatgcaaa ccataaaggg
    18661 ggattatgaa caatcctgaa tgtgcttgaa tatccggaac actatgccaa acccattaca
    18721 tggacctgtt agcagagttg acgaaaagca gtccagtcgc tccagctcac ttcacttcgt
    18781 taattcaaat ttctgaagaa ggatcctcaa gtttactaaa tgtatttaag tttaacaagt
    18841 cttatgaatg ataagtatat tgacatatat ttatgggtgt tataagggga ttcttggtat
    18901 tcatctatat tgtgtcattt tttatgacaa gaaaatattg ttattaatat atttatatgt
    18961 tattgtgtat ttgtgttagg taatattaca tactatagag ggggagctta atgtttatta
    19021 accgaaccat taggaaattt gggatttcag cagggattat aggtatgttt acatttgctc
    19081 taccttcagt gggcttttct atgccgctgc aaccaacaac catcgataag gtagaaggtg
    19141 attattatgt aacgtctgcg attgagaaca ttcgctgggg atcactgcct aatcgtgata
    19201 gctctccgat tcttactgta ccatcaggga gtgctgtaac gtttgatacg gtatcgcatg
    19261 agggactgat agaggatcaa gggagaaatc cagtggagta cttcggcaaa ttcggtatct
    19321 cacccgatgg agtgttggat gatgcgaagg caattgcggc gtctgcgatt aagcatgatt
    19381 atgtaaaaga cggacctcat attatcactg ggccagtagc ggttgaagga gcgatgccag
    19441 gagatgttct taaagtagaa gtcctttcgt tgcaaactcg agttccatat ggtgtcattt
    19501 ctaaccgcca tggtaaaggt gcccttccta acgaatttcc agaaaataca ggcccgcaag
    19561 agggagctag cgcaacaaaa ccggaattat ataataatgt atctatattt acgcctattg
    19621 aagaaatcaa cggcaattgg tatggtttat taccaacaaa agctggcaag aaggtacgtt
    19681 ttccaattaa cccgtttcta ggtgtgatgg gggttgcgcc aaataccagc gaagttgtga
    19741 gttctatccc gcctattgaa acaggaggca atatggatat taatgagtta ggtgttggtg
    19801 cgactattta ttatccgatt caagttaaag gcgggttatt ctatactgga gatccgcact
    19861 ttgctcaagg agatggagaa gtagcgttaa ctgcattgga agcttccttg agggggacag
    19921 ttcggttaac ggtattaaag gaaggtgatc catccctacc acatcgtgga gaatttacgc
    19981 aaccctttgc tgaaacagag gattattgga ttcccattgg actggaccct gatttggatg
    20041 aagcaatgaa agaatcagtg cgtgaatcga ttcaattttt atccgataag ctcgatatgg
    20101 ataggagtgt agcttatgct tatctgtcgg ctgcaacgga ttatgaagta tctcaggtcg
    20161 tagaccgaac taaaggggtt catggactca ttcgaaagac tgatttcctt gaatatgttg
    20221 acattatcat gaatgtaggt ggtacgttaa tcaaaccggt tgttcataac aatgagttct
    20281 atgtaccgat tcgaacaatt tcggagcttt taggcggtac agtagtgtgg gataataagt
    20341 cgcgtacaac gcaaatcaaa ttaggcacaa aaaatataag tgctcaaatt ggttcagatg
    20401 tgtattcaat taacgataaa ctagtgttca atagtaaagt accaaagctt ttaaatggcg
    20461 aaaccgtagt tccggtttcc gttattaatg aaatactggg tgcttatgta aactggacga
    20521 cgatcgacaa gacgttaaca gcaaatgtat cgttaagtaa aaagcaataa tagatttcat
    20581 ccagaagccc gcgaaaaacg cgggcttttt ttatctctaa tatttgtatg gttaacaatt
    20641 caatatcagt tctacccatt acggtagaga aatatttttt gaccattaaa tgttgggagg
    20701 aatcttttaa aaccccggtt tcacagtatt tataggctgc ttagttttcg atgataattc
    20761 tgtccaactt gagattaacc ggatgtgcca gcgtatctcc aaccggacac ttgctctcca
    20821 gaaattgtac aaatgcttca acctgctctt gaggagaatc tgttttgatg cggaacgtat
    20881 accgaatatc ggaatagccc ggacgcacct ctgatttgtc gaaaaagcca tccaggtcta
    20941 tatcgccttc tacatctaca aagaaatcat tgaggttcac cccgaattta ggcgcatata
    21001 ccctggctac gatcgactga catgctccca gcgaggcgag taaagcttcc accggattca
    21061 tgccggtatc agtgccaccc aagcttttgg gctcgtcgat aataaactcg aagtttcggg
    21121 atgctacttt cactcgaact ccgttttgca gatgagcaga tgctttaaac gtttggaggg
    21181 cagacatttt gtagtctcct ttagttgttt tttttaatac tcattttatt catagttttc
    21241 cgctatgatt atattaaatt ggactgcttg ctctgtcaac ccttaatttt ccaataggtt
    21301 gatctcggga acagcgcaaa gaatcctatg ctggtctata aagctgctta ggcgaatatt
    21361 cagtgtgtcc tgctgccgtt cgtattggtg atttgaaagt acgtattcaa ttcgagataa
    21421 ctgtttattg catttagaag cggatgaatt caaaaaaacc acccctgtcc cgcaaaatgg
    21481 agggagagag gtggttacac gaacgatatt taaatccttt gattaatgat tttttttaat
    21541 tctgtgtaag attgatgatt tttaattcag cgtatcatcg gtatagcttc agctcagcaa
    21601 tagaccacca ccactcagca ttgtccgtag tcaaagcaat tttgacatat cgtgccttct
    21661 ggttcgtgaa tgtcactgag attaaaggat ctgttcccac agcgtctgaa accgaattcc
    21721 attgctcgcc atctgttgaa gtaaagattg caaaactgcg ggcatagtca ttggtgctgc
    21781 tgcctgagtc catagttaac cggctgaaat cctggatgct tcccagatcg atctgaatcc
    21841 actggtctgc ttgttgtccg gatgcagagg tccagcgtga gttcagatca tcatccagca
    21901 gtgcaccaac gtcttccgac gtggaagctg tagttgtcca ggatgtccga tccagttcgg
    21961 taggcaacag atcatcctgt tccccgggtg cccatggtgt ctgatcggca gtataaactg
    22021 cgatttcagc tacagaccac cag
//
