Select genomic region:
Overview
1.1
1.2
1.3
1.4
2.1
4.1
5.1
6.1
12.1
12.2
13.1
20.1
23.1
26.1
30.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_JAHXMW010000001.1 (Paenibacillus silvae)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | lassopeptide | 534,762 | 558,749 | Low | paeninodin | ribosomal:unmodified
Region 1.2 | NRPS-like | 843,575 | 887,276 |
Region 1.3 | terpene-precursor | 1,436,092 | 1,458,515 |
Region 1.4 | T3PKS | 1,515,760 | 1,556,935 |

NZ_JAHXMW010000010.1 (Paenibacillus silvae)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | NRPS | 172,567 | 224,675 |

NZ_JAHXMW010000012.1 (Paenibacillus silvae)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 4.1 | lanthipeptide-class-ii | 45,120 | 73,984 |

NZ_JAHXMW010000013.1 (Paenibacillus silvae)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 5.1 | proteusin | 56,874 | 77,134 |

NZ_JAHXMW010000014.1 (Paenibacillus silvae)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 6.1 | NI-siderophore | 27,453 | 63,207 | Low | schizokinen | NRPS:Type IV

NZ_JAHXMW010000002.1 (Paenibacillus silvae)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 12.1 | phosphonate | 331,963 | 354,005 | Medium | rhizocticin A | other:other
Region 12.2 | transAT-PKS,NRPS,T1PKS | 414,760 | 478,037 | Low | pellasoren/pellasoren B | NRPS:Type I+PKS:Type I

NZ_JAHXMW010000020.1 (Paenibacillus silvae)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 13.1 | NRPS | 1 | 53,738 | Low | octapeptin C4 | NRPS:Type I

NZ_JAHXMW010000027.1 (Paenibacillus silvae)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 20.1 | NRPS | 1 | 26,194 | High | polymyxin B | NRPS:Type I

NZ_JAHXMW010000003.1 (Paenibacillus silvae)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 23.1 | terpene | 168,035 | 188,907 | Low | carotenoid | terpene

NZ_JAHXMW010000005.1 (Paenibacillus silvae)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 26.1 | transAT-PKS,NRPS | 159,205 | 222,513 | Low | paenilipoheptin | NRPS:Type I+PKS

NZ_JAHXMW010000009.1 (Paenibacillus silvae)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 30.1 | terpene-precursor | 82,474 | 103,397 |  |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | lassopeptide | 534,762 | 558,749 | Low | paeninodin | ribosomal:unmodified
Region 1.2 | NRPS-like | 843,575 | 887,276 |
Region 1.3 | terpene-precursor | 1,436,092 | 1,458,515 |
Region 1.4 | T3PKS | 1,515,760 | 1,556,935 |
Region 2.1 | NRPS | 172,567 | 224,675 |
Region 4.1 | lanthipeptide-class-ii | 45,120 | 73,984 |
Region 5.1 | proteusin | 56,874 | 77,134 |
Region 6.1 | NI-siderophore | 27,453 | 63,207 | Low | schizokinen | NRPS:Type IV
Region 12.1 | phosphonate | 331,963 | 354,005 | Medium | rhizocticin A | other:other
Region 12.2 | transAT-PKS,NRPS,T1PKS | 414,760 | 478,037 | Low | pellasoren/pellasoren B | NRPS:Type I+PKS:Type I
Region 13.1 | NRPS | 1 | 53,738 | Low | octapeptin C4 | NRPS:Type I
Region 20.1 | NRPS | 1 | 26,194 | High | polymyxin B | NRPS:Type I
Region 23.1 | terpene | 168,035 | 188,907 | Low | carotenoid | terpene
Region 26.1 | transAT-PKS,NRPS | 159,205 | 222,513 | Low | paenilipoheptin | NRPS:Type I+PKS
Region 30.1 | terpene-precursor | 82,474 | 103,397 |  |

No secondary metabolite regions were found in these records:
  NZ_JAHXMW010000011.1 (Paenibacillus silvae)
  NZ_JAHXMW010000015.1 (Paenibacillus silvae)
  NZ_JAHXMW010000016.1 (Paenibacillus silvae)
  NZ_JAHXMW010000017.1 (Paenibacillus silvae)
  NZ_JAHXMW010000018.1 (Paenibacillus silvae)
  NZ_JAHXMW010000019.1 (Paenibacillus silvae)
  NZ_JAHXMW010000021.1 (Paenibacillus silvae)
  NZ_JAHXMW010000022.1 (Paenibacillus silvae)
  NZ_JAHXMW010000023.1 (Paenibacillus silvae)
  NZ_JAHXMW010000024.1 (Paenibacillus silvae)
  NZ_JAHXMW010000025.1 (Paenibacillus silvae)
  NZ_JAHXMW010000026.1 (Paenibacillus silvae)
  NZ_JAHXMW010000028.1 (Paenibacillus silvae)
  NZ_JAHXMW010000029.1 (Paenibacillus silvae)
  NZ_JAHXMW010000030.1 (Paenibacillus silvae)
  NZ_JAHXMW010000004.1 (Paenibacillus silvae)
  NZ_JAHXMW010000006.1 (Paenibacillus silvae)
  NZ_JAHXMW010000007.1 (Paenibacillus silvae)
  NZ_JAHXMW010000008.1 (Paenibacillus silvae)

Compact view
NZ_JAHXMW010000001.1 - Region 1 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 534,762 - 558,749 nt. (total: 23,988 nt) Show pHMM detection rules used
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lasso peptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: deacetylase hydrolase
KZX51_RS02645: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

KZX51_RS02690: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Lyases: cyclase
KZX51_RS02620: diguanylate cyclase

smcogs
  SMCOG1025: diguanylate cyclase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001356.4 |  | 0.68 | ribosomal | paeninodin | Paenibacillus dendritiformis C454
BGC0002151.2 |  | 0.55 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0002150.2 |  | 0.55 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002312.2 |  | 0.53 | ribosomal | ubonodin | Burkholderia ubonensis
BGC0001634.3 |  | 0.53 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000575.5 |  | 0.52 | ribosomal | lariatin | Rhodococcus jostii
BGC0001889.2 |  | 0.50 | ribosomal | fusilassin | Thermobifida fusca YX
BGC0002289.2 |  | 0.50 | ribosomal | Leepeptin | Streptomyces leeuwenhoekii
BGC0001639.3 |  | 0.46 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0001496.3 |  | 0.46 | ribosomal | actinokineosin | Actinokineospora spheciospongiae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001356.4 |  | 0.68 | ribosomal | paeninodin | Paenibacillus dendritiformis C454
BGC0002151.2 |  | 0.55 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0002150.2 |  | 0.55 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002312.2 |  | 0.53 | ribosomal | ubonodin | Burkholderia ubonensis
BGC0001634.3 |  | 0.53 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000575.5 |  | 0.52 | ribosomal | lariatin | Rhodococcus jostii
BGC0001889.2 |  | 0.50 | ribosomal | fusilassin | Thermobifida fusca YX
BGC0002289.2 |  | 0.50 | ribosomal | Leepeptin | Streptomyces leeuwenhoekii
BGC0001639.3 |  | 0.46 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0001496.3 |  | 0.46 | ribosomal | actinokineosin | Actinokineospora spheciospongiae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Each core peptide shows the leader and core peptide sequences.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
Lassopeptides - No core peptides found.
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.65 out of 18.46
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
Additional weak hits (4):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.28 out of 30.25
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.34 out of 36.54
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.77 out of 32.93
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.62 out of 25.75
Confidence: weak
Lasso peptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
RRE predictions
RREfinder results sidepanel.

lassopeptide protocluster (534761...558749)
KZX51_RS02660
  RRE type: Stand_Alone_Lasso_RRE
  Location: 12 - 95
  Score: 93.7

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis

NZ_JAHXMW010000001.1 - Region 2 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 843,575 - 887,276 nt. (total: 43,702 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: acetyltransferase
KZX51_RS04085: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

Ligases: ligase
KZX51_RS04070: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Translocases: transport
KZX51_RS04120: MMPL domain-containing transport protein

smcogs
  SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002164.2 |  | 0.60 | NRPS | peramine | Epichloe festucae
BGC0001135.5 |  | 0.60 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002135.2 |  | 0.60 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001250.4 |  | 0.60 | NRPS | epichloenin A | Epichloe festucae
BGC0001251.4 |  | 0.60 | NRPS | epichloenin A | Epichloe festucae
BGC0001166.5 |  | 0.60 | NRPS | HC-toxin | Alternaria jesenskae
BGC0000307.4 |  | 0.60 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001249.5 |  | 0.60 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0002276.2 |  | 0.59 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001240.4 |  | 0.59 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002164.2 |  | 0.60 | NRPS | peramine | Epichloe festucae
BGC0001135.5 |  | 0.60 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002135.2 |  | 0.60 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001250.4 |  | 0.60 | NRPS | epichloenin A | Epichloe festucae
BGC0001251.4 |  | 0.60 | NRPS | epichloenin A | Epichloe festucae
BGC0001166.5 |  | 0.60 | NRPS | HC-toxin | Alternaria jesenskae
BGC0000307.4 |  | 0.60 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001249.5 |  | 0.60 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0002276.2 |  | 0.59 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001240.4 |  | 0.59 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.25 out of 18.46
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.31 out of 18.46
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.58 out of 27.78
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.19 out of 21.55
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.00 out of 28.19
Confidence: medium
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.57 out of 25.31
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.33 out of 28.19
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.27 out of 24.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.30 out of 26.06
Confidence: medium
Additional weak hits (8):
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.05 out of 33.73
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.85 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.41 out of 28.14
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.62 out of 21.55
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.62 out of 29.25
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.63 out of 26.12
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.49 out of 27.04
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 843574 - 887276:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KZX51_RS04070: X
AMP-binding (225..634): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Unpolar aromatic ring (Phe, Trp)
  Single AA prediction:
    phe (Phe)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LVVAFDASVWDGTITVAGEVNVYGPTECTVATTT
  Nearest Stachelhaus code(s):
    bMe-Phe DAWTTAVAAK (65% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
ArcA | Repressor of carbon oxidation
CatR | H2O2-responsive repressor
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_JAHXMW010000001.1 - Region 3 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,436,092 - 1,458,515 nt. (total: 22,424 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase reductase
KZX51_RS06625: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

KZX51_RS06665: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

Ligases: synthetase
KZX51_RS06635: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0002150.2 |  | 0.42 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.42 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000551.5 |  | 0.42 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0002699.2 |  | 0.41 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002260.3 |  | 0.40 | terpene | trichobrasilenol, xylarenic acid B, brasilane A, brasilane F, brasilane E, brasilane D | Annulohypoxylon truncatum
BGC0001210.5 |  | 0.40 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000554.4 |  | 0.40 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0002150.2 |  | 0.42 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.42 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000551.5 |  | 0.42 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0002699.2 |  | 0.41 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002260.3 |  | 0.40 | terpene | trichobrasilenol, xylarenic acid B, brasilane A, brasilane F, brasilane E, brasilane D | Annulohypoxylon truncatum
BGC0001210.5 |  | 0.40 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000554.4 |  | 0.40 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
KZX51_RS06635: PT_FPPS_like
Domain 1 (549 - 770): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.96 out of 27.78
Confidence: medium
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 20.04 out of 23.43
Confidence: medium
Additional weak hits (4):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.27 out of 31.73
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.16 out of 36.54
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.96 out of 30.22
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.01 out of 35.63
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
BldD | Development and antibiotic global regulator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_JAHXMW010000001.1 - Region 4 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,515,760 - 1,556,935 nt. (total: 41,176 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
KZX51_RS06905: FAD dependent oxidoreductase

smcogs
  SMCOG1103: FAD dependent oxidoreductase

KZX51_RS06995: oxidoreductase

smcogs
  SMCOG1161: oxidoreductase

KZX51_RS07085: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase aminotransferase methyltransferase
KZX51_RS06915: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

KZX51_RS06960: methyltransferase

smcogs
  SMCOG1248: methyltransferase

KZX51_RS07000: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: hydrolase
KZX51_RS06940: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

KZX51_RS06980: alpha/beta hydrolase domain-containing protein

smcogs
  SMCOG1066: alpha/beta hydrolase domain-containing protein

Ligases: synthase
KZX51_RS06985: chalcone and stilbene synthase domain protein

smcogs
  SMCOG1024: chalcone and stilbene synthase domain protein

Translocases: transporter
KZX51_RS07025: sugar-binding lipoprotein

smcogs
  SMCOG1143: sugar-binding lipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001310.5 |  | 0.53 | PKS | naringenin | Streptomyces clavuligerus ATCC 27064
BGC0001962.3 |  | 0.51 | PKS | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0000584.5 |  | 0.47 | ribosomal | colicin V | Escherichia coli
BGC0002332.2 |  | 0.47 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001831.3 |  | 0.45 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0000589.5 |  | 0.44 | ribosomal | microcin M | Escherichia coli Nissle 1917
BGC0001964.2 |  | 0.44 | PKS | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001374.5 |  | 0.42 | other (other) | thienodolin | Streptomyces albogriseolus
BGC0001555.4 |  | 0.42 | ribosomal | colicin V | Escherichia coli chi7122

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001310.5 |  | 0.53 | PKS | naringenin | Streptomyces clavuligerus ATCC 27064
BGC0001962.3 |  | 0.51 | PKS | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0000584.5 |  | 0.47 | ribosomal | colicin V | Escherichia coli
BGC0002332.2 |  | 0.47 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001831.3 |  | 0.45 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0000589.5 |  | 0.44 | ribosomal | microcin M | Escherichia coli Nissle 1917
BGC0001964.2 |  | 0.44 | PKS | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001374.5 |  | 0.42 | other (other) | thienodolin | Streptomyces albogriseolus
BGC0001555.4 |  | 0.42 | ribosomal | colicin V | Escherichia coli chi7122

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.20 out of 20.01
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.88 out of 28.19
Confidence: medium
Additional weak hits (6):
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.99 out of 20.01
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.11 out of 36.54
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.16 out of 29.25
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.22 out of 20.47
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.39 out of 36.54
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.53 out of 33.73
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArgR | Regulator of arginine biosynthesis genes
ZuR variant 1 | Zinc-responsive repressor

NZ_JAHXMW010000010.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 172,567 - 224,675 nt. (total: 52,109 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
KZX51_RS22335: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

KZX51_RS22375: Dioxygenase TauD/TfdA

smcogs
  SMCOG1046: Dioxygenase TauD/TfdA

Transferases: methyltransferase
KZX51_RS22435: methyltransferase

smcogs
  SMCOG1089: methyltransferase

Hydrolases: hydrolase
KZX51_RS22300: alpha/beta hydrolase domain-containing protein

smcogs
  SMCOG1066: alpha/beta hydrolase domain-containing protein

KZX51_RS22365: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Ligases: ligase
KZX51_RS22370: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

KZX51_RS22380: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

KZX51_RS22385: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Translocases: permease
KZX51_RS22330: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001833.4 |  | 0.71 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.4 |  | 0.70 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.69 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.69 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.69 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001758.4 |  | 0.68 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002135.2 |  | 0.68 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001133.4 |  | 0.67 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001833.4 |  | 0.71 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.4 |  | 0.70 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.69 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.69 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.69 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001758.4 |  | 0.68 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002135.2 |  | 0.68 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001133.4 |  | 0.67 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.79 out of 27.78
Confidence: medium
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.47 out of 20.01
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.30 out of 24.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.95 out of 28.19
Confidence: medium
Additional weak hits (6):
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.71 out of 21.55
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.42 out of 26.06
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.70 out of 27.55
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.08 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.37 out of 29.38
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.89 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 172566 - 224675:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Asn) + (Gln) + (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KZX51_RS22370: Asn
Search NORINE for peptide: strict or relaxed
AMP-binding (467..860): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTVTSTKLIVGGDFNEYGPTETVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

KZX51_RS22380: Gln
Search NORINE for peptide: strict or relaxed
AMP-binding (453..847): Gln
nrpys: Gln

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    gln (Gln)

Stachelhaus prediction details:
  Stachelhaus sequence:
    HWMTFDASVWEAQVFSGGEINLYGPTEAAVDTTF
  Nearest Stachelhaus code(s):
    Gln DAWQFGLVDK (62% 8Å match)
  Stachelhaus code match:
    100% (strong)

KZX51_RS22385: X
AMP-binding (500..902): X
nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDDVGLEWFFFSSGEHNSYGVTEVSIDSTV
  Nearest Stachelhaus code(s):
    Ser DVWHFSLIDK (68% 8Å match)
    Dab DVGEISSIDK (38% 8Å match)
  Stachelhaus code match:
    60% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArgR | Regulator of arginine biosynthesis genes
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2 | Repressor of DNA damage response
MexT | Global virulence regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_JAHXMW010000012.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 45,120 - 73,984 nt. (total: 28,865 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
KZX51_RS23845: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

KZX51_RS23860: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000517.4 |  | 0.57 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000525.5 |  | 0.54 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000552.3 |  | 0.54 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0002110.3 |  | 0.54 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0001311.5 |  | 0.53 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000623.3 |  | 0.53 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001229.4 |  | 0.52 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000539.5 |  | 0.51 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000500.5 |  | 0.51 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000517.4 |  | 0.57 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000525.5 |  | 0.54 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000552.3 |  | 0.54 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0002110.3 |  | 0.54 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0001311.5 |  | 0.53 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000623.3 |  | 0.53 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001229.4 |  | 0.52 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000539.5 |  | 0.51 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000500.5 |  | 0.51 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for KZX51_RS23845

KZX51_RS23840
Leader:
MKALEMIGEINEQELMELSGA
Core:
T E V Q V A S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
Core with dehydrations:
Dhb E V Q V A Dha Dha W P Cys A I V P P V L I W Dhb I Dhb D Dha A N Dha Cys P Dha Dhb A Cys Dha Dha R Cys

#### antiSMASH-DB 4.0 matches for KZX51_RS23840

100.0%
NZ_JAHXMW010000012.1 and 3 others:
NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23840_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24460_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24460_lanthipeptide
Lanthipeptides: KZX51_RS23840_lanthipeptide
1
T E V Q V A S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
T E V Q V A S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
1
T E V Q V A S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
94.7%
NZ_BMFU01000012.1 and 1 other:
NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25390_lanthipeptide
Lanthipeptides: IEW26_RS25390_lanthipeptide
1
T E V Q V A S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
T E V Q A S S W P C A I V P P V+I W T I T D S A N S C P S T A C S S R C
1
T E V Q A A S S W P C A I V P P V V I W T I T D S A N S C P S T A C S S R C
38
94.7%
NZ_JACHKG010000014.1 and 1 other:
NZ_JACHKG010000014.1 Lanthipeptides: HNR77_RS17300_lanthipeptide
Lanthipeptides: HNR77_RS17300_lanthipeptide
2
E V Q V A S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
E V Q V A S S W P C A I V P P V+I W T I T D S A N S C P S T A C S S R C
2
E V Q V A S S W P C A I V P P V V I W T I T D S A N S C P S T A C S S R C
38
with 92 more sequence matches
Only the first 10 are displayed here.
68.4%
NZ_JALIRS010000003.1 and 3 others:
NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07280_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06785_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06785_lanthipeptide
Lanthipeptides: MOK21_RS07280_lanthipeptide
2
E V Q V A S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
E V S S W C I V I W T I T D S N S C P S T A C S+R C
2
E V N P R S S W G C V I--D V T I W T I T D S M N S C P S T A C S T R C
36
60.5%
NZ_JALIRS010000003.1 and 7 others:
NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07275_lanthipeptide NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07270_lanthipeptide NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07270_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06790_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06790_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06795_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06795_lanthipeptide
Lanthipeptides: MOK21_RS07275_lanthipeptide
2
E V Q V A S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
E V S S W C + V I+T I+D S N S C P S T A C S+R C
2
E V N P R S S W G C V V--Q V T I Y T I S D S M N S C P S T A C S T R C
36
47.4%
NZ_QORY01000016.1 and 1 other:
NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide
Lanthipeptides: DT250_RS18265_lanthipeptide
2
E V Q V A S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
E V ++W C A I +T I S A C P+T A C S S+C
3
E V T P Y T T W G C A I------F T I A-S A A Q C P T T A C S S K C
32
41.0%
NZ_NTWJ01000043.1 and 1 other:
NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29340_lanthipeptide
Lanthipeptides: CN427_RS29340_lanthipeptide
2
E V Q V A S S W P C A-I V P P V L I W T I T D S A N S C P S T A C S S R C
38
E V+ S S P C A + V W S +C P+ A C S C
2
E V E T R S S L P C A G L T V A V G T W V F Q T S E K T C P T L A C S K A C
39
40.5%
NZ_NTSR01000029.1 and 1 other:
NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide
Lanthipeptides: CN358_RS25165_lanthipeptide
2
E V Q V A S S W P C A I V P P---V L I W T I T D S A N S C P S T A C S S R C
38
E V ++ P C A+ + I+T S S C P++A C S S R C
2
E V N P R T T V P C A V G G A T V G I T I Y T F D R S H Q S C P T S A C S S R C
41
39.5%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00390_lanthipeptide
Lanthipeptides: CWT12_RS00390_lanthipeptide
7
S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
S S W P C I I T + C P+ A C S S+C
5
S S W P C G I-------G I T T T V--C P T A A C S S K C
27
38.5%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide
Lanthipeptides: P40081_RS37160_lanthipeptide
7
S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
S S W P C +I + S A N C P+T C+S+C
14
S S W P C------V I G A V D I S A N L C P T T K C T S K C
39
38.5%
NZ_NTWJ01000043.1 and 1 other:
NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS31525_lanthipeptide
Lanthipeptides: CN427_RS31525_lanthipeptide
2
E V Q V A S S W P C-A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
E V+ S S P C ++ V W S +C P+ A C S C
2
E V E T R S S V P C V S L T V A V G T W V F Q T S D K T C P T L A C S K A C
39
36.8%
NC_006322.1 and 7 others:
NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide
Lanthipeptides: BLI_RS20290_lanthipeptide
7
S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
S S W C + +T S A+ C P+T C+S R C
13
S S W T C------I T A G V T V S A S L C P T T K C T S R C
38
36.8%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide
Lanthipeptides: LDO05_RS02090_lanthipeptide
7
S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
S S W C + S A C P S T A C+S+C
7
S S W I C G V A----------S A A F C P S T A C T S K C
28

#### MIBiG 4.0 matches for KZX51_RS23840

23.7%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
25
S A N S C P S T A C S S R C
38
S A C P+T C+S R C
24
S A A F C P T T K C T S R C
37
15.8%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
29
C P S T A C S S R C
38
C P+T C+S+C
17
C P T T K C T S K C
26
KZX51_RS23855
Leader:
MSYQALKNPYSRTHNNVLPIENPLVELKEDELLKAG
Core:
G A A Q P E W V E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
Core with dehydrations:
G A A Q P E W V E V I I Dhb Dha L A Cys A A A Dha Y F M G N P G H V Cys Dhb L Dhb V E Cys Q K Dha Cys N

#### antiSMASH-DB 4.0 matches for KZX51_RS23855

100.0%
NZ_BMFU01000012.1 and 5 others:
NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25375_lanthipeptide NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptide NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide
Lanthipeptides: IEW26_RS25375_lanthipeptide
1
G A A Q P E W V E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
G A A Q P E W V E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
1
G A A Q P E W V E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
95.2%
NZ_JACHKG010000014.1 and 1 other:
NZ_JACHKG010000014.1 Lanthipeptides: allorf_027480_027638_lanthipeptide
Lanthipeptides: allorf_027480_027638_lanthipeptide
1
G A A Q P E W V E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
G A A Q P+W E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
1
G A A Q P Q W A E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
73.8%
NZ_JALIRS010000003.1 and 3 others:
NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide
Lanthipeptides: MOK21_RS07255_lanthipeptide
4
Q P E W V E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
Q W E I+T S L A C A A A S Y +G N P G H V C T L T V E C Q K C N
2
Q E R W A E T I L T S L A C A A A S Y I L G N P G H V C T L T V E C Q K K C N
40
with 98 more sequence matches
Only the first 10 are displayed here.
45.2%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide
Lanthipeptides: MT347_RS12955_lanthipeptide
12
I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
I T S L C S+ G N G V C T T V E C Q +C N
9
I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
45.2%
NZ_NTSR01000029.1 and 1 other:
NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25180_lanthipeptide
Lanthipeptides: CN358_RS25180_lanthipeptide
1
G A A Q P E W V E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
G A A+P + S S +G N G++C T T V E C Q K+C N
1
G A A E P R T I G S F-N S A D Y I K L S I G L G N N G Y I C T Y T V E C Q K N C N
41
40.5%
NZ_BMRY01000003.1 and 24 others:
NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide
Lanthipeptides: IE140_RS12370_lanthipeptide
10
V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C
41
I++S L+C A S Y +G N G+ C T T E C Q +C
6
T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C
37
40.5%
NZ_CP013862.1 and 1 other:
NZ_CP013862.1 Lanthipeptides: AOX59_RS09360_lanthipeptide
Lanthipeptides: AOX59_RS09360_lanthipeptide
9
E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
+ +T C S M G N G H+C T T V E C Q +C N
5
Q T A L T Y S T C H W I S P A M G N D G H L C T A T V E C Q P N C N
38
40.5%
NZ_CP115450.1 and 1 other:
NZ_CP115450.1 Lanthipeptides: O1G21_RS35415_lanthipeptide
Lanthipeptides: O1G21_RS35415_lanthipeptide
12
I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C
41
I L A A S+ M G N G++C T+T E C Q K+C
6
I E V L T Y T A A S W A M G N N G Y L C T V T A E C Q K N C
35
40.5%
NZ_JAQFWW010000002.1 and 1 other:
NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide
Lanthipeptides: PDT38_RS11330_lanthipeptide
11
I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
++T+L+C A A S +G+ G V C T T V E C Q +C
6
L L T T L S C L A A S I M I G D K G Q V C T G T V E C Q N N C R
37
40.5%
NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide
Lanthipeptides: BN6628_RS02285_lanthipeptide
11
I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
++T+L A C A S Y +G+ G V C T T V E C +C
6
V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R
37
38.1%
NC_006322.1 and 7 others:
NC_006322.1 Lanthipeptides: BLI_RS20295_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptide
Lanthipeptides: BLI_RS20295_lanthipeptide
12
I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
I T C A S +G N G++C T+T E C S C N
2
I T L S T C A I L S K P L G N N G Y L C T V T K E C M P S C N
32
38.1%
NZ_BMVL01000013.1 and 1 other:
NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide
Lanthipeptides: IE257_RS28650_lanthipeptide
11
I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C
41
I ++ A S+ +G N G H+C T+T V E C Q K+C
2
I F E T V T Y T V A S W A L G N N G H L C T V T V E C Q K N C
32
38.1%
NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24800_lanthipeptide
Lanthipeptides: LL065_RS24800_lanthipeptide
7
W V E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C
41
W V I+ A S Y +G N G +C T +V E C Q +C
2
W V S T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
36

#### MIBiG 4.0 matches for KZX51_RS23855

31.0%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
24
M G N P G H V C T L T V E C Q K S C N
42
+G N G C T L T V E C S C N
10
L G N K G A Y C T L T V E C M P S C N
28
31.0%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
19
A A S Y F M G N P G H V C T L T V E C Q K S C N
42
+ S +G N G C T L T E C Q +C N
7
S L S N A L G N N G G W C T L T K E C Q P N C N
30
19.0%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
31
C T L T V E C Q K S C N
42
C T L+ E C Q +C N
28
C T L S K E C Q P N C N
39
with 1 more sequence matches
7.1%
BGC0000503.5 (cinA):
Lanthipeptide: cinnamycin
37
C Q K S C N
42
C++S C+
1
C R Q S C S
6
allorf_047087_047290
Leader:
MYRNSRRNHTGA
Core:
I G Q M L K P A A S L S H T L V Y T N S I Q P I R T A P K N Y R V H C S H L V A M N F F T Q F M H A A D C P I
Core with dehydrations:
I G Q M L K P A A Dha L Dha H Dhb L V Y Dhb N Dha I Q P I R Dhb A P K N Y R V H Cys Dha H L V A M N F F Dhb Q F M H A A D Cys P I

#### antiSMASH-DB 4.0 matches for allorf_047087_047290

100.0%
NZ_JAHXMW010000012.1:
Lanthipeptides: allorf_047087_047290_lanthipeptide
1
I G Q M L K P A A S L S H T L V Y T N S I Q P I R T A P K N Y R V H C S H L V A M N F F T Q F M H A A D C P I
55
I G Q M L K P A A S L S H T L V Y T N S I Q P I R T A P K N Y R V H C S H L V A M N F F T Q F M H A A D C P I
1
I G Q M L K P A A S L S H T L V Y T N S I Q P I R T A P K N Y R V H C S H L V A M N F F T Q F M H A A D C P I
55
14.3%
NZ_CP029607.1:
Lanthipeptides: allorf_6468650_6468883_lanthipeptide
6
K P A A S L S H T L V Y T N S I Q P I R T A P
28
+P A S+ V+T P R A P
16
R P P A S V R P P S V W T T D A P P A R R A P
38
12.7%
NZ_BJTV01000007.1:
Lanthipeptides: allorf_023321_023548_lanthipeptide
17
Y T N S I Q P I R T A P K N Y R V H C S H L V
39
+ + ++A P+ Y R C S V
14
W V R D L H R W K S A P R P Y R T A C S W Y V
36

#### MIBiG 4.0 matches for allorf_047087_047290

10.9%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
20
S I Q P I R T A P K N Y R V
33
+I P I T +R V
1
T I S P I D T V K I I F R V
14
10.9%
BGC0002120.3 (NQE92413.1):
Lanthipeptide: nocathioamide A
6
K P A A S L S H T L
15
+P A A H T L
34
R P A A P A C H T L
43
allorf_051170_051277
Leader:
MLLIVHGS
Core:
P D V N L Q D E G V T A H I T A Y D V C L G K L Y F R
Core with dehydrations:
P D V N L Q D E G V Dhb A H I Dhb A Y D V Cys L G K L Y F R

#### antiSMASH-DB 4.0 matches for allorf_051170_051277

100.0%
NZ_JAHXMW010000012.1 and 1 other:
NZ_JAHXMW010000012.1 Lanthipeptides: allorf_051170_051277_lanthipeptide
Lanthipeptides: allorf_051170_051277_lanthipeptide
1
P D V N L Q D E G V T A H I T A Y D V C L G K L Y F R
27
P D V N L Q D E G V T A H I T A Y D V C L G K L Y F R
1
P D V N L Q D E G V T A H I T A Y D V C L G K L Y F R
27
22.2%
NZ_AP023438.1 and 1 other:
NZ_AP023438.1 Lanthipeptides: IGA62_RS12300_lanthipeptide
Lanthipeptides: IGA62_RS12300_lanthipeptide
7
D E G V T A H I T A Y D V C L G K
23
D+G + T + C G K
9
D D G C G S G N T G S N A C T G K
25
18.5%
NZ_JAGGRJ010000031.1:
Lanthipeptides: allorf_016614_016724_lanthipeptide
8
E G V T A H I T A Y D V C L G K L
24
+ V A +++C L G++
2
D S V R A T P P P F N L C L G R I
18
with 1 more sequence matches
14.0%
NZ_JADIKF010000040.1:
Lanthipeptides: ISS99_RS17245_lanthipeptide
14
I T A Y D V C L G K L
24
+T A Y V C G+
20
V T A Y A V C S G R C
30
allorf_051496_051735
Leader:
MCSTFAPYSRIILEPFLYEGAFMDSTGIVRAWVAGS
Core:
G D A S A S S T L K P I K R Q T T N K L R F R S L R N C V R A S N L H R P C D R I R G
Core with dehydrations:
G D A Dha A Dha Dha Dhb L K P I K R Q Dhb Dhb N K L R F R Dha L R N Cys V R A Dha N L H R P Cys D R I R G

#### antiSMASH-DB 4.0 matches for allorf_051496_051735

100.0%
NZ_JAHXMW010000012.1 and 2 others:
NZ_JAHXMW010000012.1 Lanthipeptides: allorf_051496_051735_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: allorf_139409_139648_lanthipeptide
Lanthipeptides: allorf_051496_051735_lanthipeptide
1
G D A S A S S T L K P I K R Q T T N K L R F R S L R N C V R A S N L H R P C D R I R G
43
G D A S A S S T L K P I K R Q T T N K L R F R S L R N C V R A S N L H R P C D R I R G
1
G D A S A S S T L K P I K R Q T T N K L R F R S L R N C V R A S N L H R P C D R I R G
43
97.7%
NZ_JACHKG010000014.1:
Lanthipeptides: allorf_017085_017312_lanthipeptide
1
G D A S A S S T L K P I K R Q T T N K L R F R S L R N C V R A S N L H R P C D R I R G
43
G D A S A S T L K P I K R Q T T N K L R F R S L R N C V R A S N L H R P C D R I R G
1
G D A S A L S T L K P I K R Q T T N K L R F R S L R N C V R A S N L H R P C D R I R G
43
13.0%
NZ_CP008953.1 and 1 other:
NZ_JPLW01000002.1 Lanthipeptides: allorf_1064250_1064342_lanthipeptide
Lanthipeptides: allorf_3865033_3865224_lanthipeptide
31
A S N L H R P C D R I
41
A S N H R P C +
35
A S N G H R P C P A V
45
allorf_051732_051842
Leader:
MMSPEYRPVTGYTLGQPDCLLQHTPGG
Core:
D V T A Y P T T C
Core with dehydrations:
D V Dhb A Y P Dhb Dhb Cys

#### antiSMASH-DB 4.0 matches for allorf_051732_051842

100.0%
NZ_JACHKG010000014.1 and 3 others:
NZ_JAHXMW010000012.1 Lanthipeptides: allorf_051732_051842_lanthipeptide NZ_JAHXMW010000012.1 Lanthipeptides: allorf_051732_051842_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: allorf_139302_139412_lanthipeptide
Lanthipeptides: allorf_017309_017419_lanthipeptide
1
D V T A Y P T T C
9
D V T A Y P T T C
1
D V T A Y P T T C
9
allorf_051847_052008
Leader:
MTTPVEAYVSLSSDRGSTPLASISSIRRSTLMGA
Core:
F F L C S Y I T S D D S L Y R L W T I
Core with dehydrations:
F F L Cys Dha Y I Dhb Dha D D Dha L Y R L W Dhb I

#### antiSMASH-DB 4.0 matches for allorf_051847_052008

100.0%
NZ_JAHXMW010000012.1 and 2 others:
NZ_JAHXMW010000012.1 Lanthipeptides: allorf_051847_052008_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: allorf_139136_139297_lanthipeptide
Lanthipeptides: allorf_051847_052008_lanthipeptide
1
F F L C S Y I T S D D S L Y R L W T I
19
F F L C S Y I T S D D S L Y R L W T I
1
F F L C S Y I T S D D S L Y R L W T I
19
31.6%
NZ_RKNR01000012.1:
Lanthipeptides: allorf_004148_004249_lanthipeptide
1
F F L C S Y I T S
9
F F L C+Y+ S
7
F F L C T Y V P S
15
17.1%
NC_017943.1:
Lanthipeptides: allorf_132120_132308_lanthipeptide
2
F L C S Y I T S D D S L Y R
15
L C T S+D L R
18
L L C D L T T S E D E L V R
31
with 2 more sequence matches
16.2%
NZ_FOJF01000001.1:
Lanthipeptides: BMW86_RS13610_lanthipeptide
7
I T S D D S L Y R L W T
18
+ D D++ R L W T
2
V G G D D T I T R L W T
13
15.8%
NZ_FNUH01000004.1 and 1 other:
NZ_FOGM01000011.1 Lanthipeptides: allorf_16865_17017_lanthipeptide
Lanthipeptides: allorf_021870_022022_lanthipeptide
1
F F L C S Y I T S D D S L Y R L W T I
19
F L C+Y I + ++ + T+
13
F L L C T Y I V N S K T I K K H L T V
31
allorf_051923_052081
Leader:
MLFCIKPNFLKQMFSS
Core:
K I L Y V Y N F L I L S K V C K E S R Q M L Y K N K E K K H P S R C F F
Core with dehydrations:
K I L Y V Y N F L I L Dha K V Cys K E Dha R Q M L Y K N K E K K H P Dha R Cys F F

#### antiSMASH-DB 4.0 matches for allorf_051923_052081

100.0%
NZ_JAHXMW010000012.1 and 2 others:
NZ_JAHXMW010000012.1 Lanthipeptides: allorf_051923_052081_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: allorf_139063_139221_lanthipeptide
Lanthipeptides: allorf_051923_052081_lanthipeptide
1
K I L Y V Y N F L I L S K V C K E S R Q M L Y K N K E K K H P S R C F F
36
K I L Y V Y N F L I L S K V C K E S R Q M L Y K N K E K K H P S R C F F
1
K I L Y V Y N F L I L S K V C K E S R Q M L Y K N K E K K H P S R C F F
36
11.9%
NZ_OCTY01000002.1:
Lanthipeptides: allorf_0873960_0874184_lanthipeptide
21
M L Y K N K E K K H P S R C
34
+L Y + + P+R C
22
L L Y T S P R P R D P T R C
35
allorf_053850_054050
Leader:
MNLKKLSLVWCNSLDKMLLLLAPIFVITAESSETHYVSGM
Core:
D Q S K G W N K A Y V G N S L L N C C P S T L N S L
Core with dehydrations:
D Q Dha K G W N K A Y V G N Dha L L N Cys Cys P Dha Dhb L N Dha L

#### antiSMASH-DB 4.0 matches for allorf_053850_054050

100.0%
NZ_JAHXMW010000012.1 and 1 other:
NZ_JAHXMW010000012.1 Lanthipeptides: allorf_053850_054050_lanthipeptide
Lanthipeptides: allorf_053850_054050_lanthipeptide
1
D Q S K G W N K A Y V G N S L L N C C P S T L N S L
26
D Q S K G W N K A Y V G N S L L N C C P S T L N S L
1
D Q S K G W N K A Y V G N S L L N C C P S T L N S L
26
88.5%
NZ_BMFU01000012.1 and 1 other:
NZ_BMFU01000012.1 Lanthipeptides: allorf_066510_066707_lanthipeptide
Lanthipeptides: allorf_066510_066707_lanthipeptide
1
D Q S K G W N K A Y V G N S L L N C C P S T L N S L
26
D Q S G W N K A V G N S L N C C P S T L N S L
1
D Q S T G W N K A C V G N S R L N C C P S T L N S L
26
84.6%
NZ_VDYW01000008.1:
Lanthipeptides: allorf_137107_137307_lanthipeptide
1
D Q S K G W N K A Y V G N S L L N C C P S T L N S L
26
D S K G W N K A Y V G+ L L N C C P S T N S L
1
D H S K G W N K A Y V G D I L L N C C P S T H N S L
26
with 2 more sequence matches
80.8%
NZ_JACHKG010000014.1 and 1 other:
NZ_JACHKG010000014.1 Lanthipeptides: allorf_020828_021025_lanthipeptide
Lanthipeptides: allorf_020828_021025_lanthipeptide
1
D Q S K G W N K A Y V G N S L L N C C P S T L N S L
26
D Q S G W N K A V G N S L N C C P S T +S L
1
D Q S T G W N K A C V G N S R L N C C P S T H S S L
26
25.0%
NZ_CP029607.1:
Lanthipeptides: allorf_6474235_6474408_lanthipeptide
3
S K G W N K A Y V G N S L L N C C P S T
22
+G W S L N C P T
2
G R G W E A G V G E R S L P N A C P R T
21
allorf_064022_064084
Leader:
MIVVLTSHSLLYS
Core:
N C K L S P T
Core with dehydrations:
N Cys K L Dha P Dhb

#### antiSMASH-DB 4.0 matches for allorf_064022_064084

100.0%
NZ_JAHXMW010000012.1 and 1 other:
NZ_JAHXMW010000012.1 Lanthipeptides: allorf_064022_064084_lanthipeptide
Lanthipeptides: allorf_064022_064084_lanthipeptide
1
N C K L S P T
7
N C K L S P T
1
N C K L S P T
7
85.7%
NZ_VDYW01000008.1:
Lanthipeptides: allorf_127072_127134_lanthipeptide
1
N C K L S P T
7
N C K S P T
1
N C K S S P T
7

#### Lanthipeptide(s) for KZX51_RS23860

KZX51_RS23840
Leader:
MKALEMIGEINEQELMELSGA
Core:
T E V Q V A S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
Core with dehydrations:
Dhb E V Q V A Dha Dha W P Cys A I V P P V L I W Dhb I Dhb D Dha A N Dha Cys P Dha Dhb A Cys Dha Dha R Cys

#### antiSMASH-DB 4.0 matches for KZX51_RS23840

100.0%
NZ_JAHXMW010000012.1 and 3 others:
NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23840_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24460_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24460_lanthipeptide
Lanthipeptides: KZX51_RS23840_lanthipeptide
1
T E V Q V A S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
T E V Q V A S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
1
T E V Q V A S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
94.7%
NZ_BMFU01000012.1 and 1 other:
NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25390_lanthipeptide
Lanthipeptides: IEW26_RS25390_lanthipeptide
1
T E V Q V A S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
T E V Q A S S W P C A I V P P V+I W T I T D S A N S C P S T A C S S R C
1
T E V Q A A S S W P C A I V P P V V I W T I T D S A N S C P S T A C S S R C
38
94.7%
NZ_JACHKG010000014.1 and 1 other:
NZ_JACHKG010000014.1 Lanthipeptides: HNR77_RS17300_lanthipeptide
Lanthipeptides: HNR77_RS17300_lanthipeptide
2
E V Q V A S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
E V Q V A S S W P C A I V P P V+I W T I T D S A N S C P S T A C S S R C
2
E V Q V A S S W P C A I V P P V V I W T I T D S A N S C P S T A C S S R C
38
with 92 more sequence matches
Only the first 10 are displayed here.
68.4%
NZ_JALIRS010000003.1 and 3 others:
NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07280_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06785_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06785_lanthipeptide
Lanthipeptides: MOK21_RS07280_lanthipeptide
2
E V Q V A S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
E V S S W C I V I W T I T D S N S C P S T A C S+R C
2
E V N P R S S W G C V I--D V T I W T I T D S M N S C P S T A C S T R C
36
60.5%
NZ_JALIRS010000003.1 and 7 others:
NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07275_lanthipeptide NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07270_lanthipeptide NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07270_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06790_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06790_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06795_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06795_lanthipeptide
Lanthipeptides: MOK21_RS07275_lanthipeptide
2
E V Q V A S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
E V S S W C + V I+T I+D S N S C P S T A C S+R C
2
E V N P R S S W G C V V--Q V T I Y T I S D S M N S C P S T A C S T R C
36
47.4%
NZ_QORY01000016.1 and 1 other:
NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide
Lanthipeptides: DT250_RS18265_lanthipeptide
2
E V Q V A S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
E V ++W C A I +T I S A C P+T A C S S+C
3
E V T P Y T T W G C A I------F T I A-S A A Q C P T T A C S S K C
32
41.0%
NZ_NTWJ01000043.1 and 1 other:
NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29340_lanthipeptide
Lanthipeptides: CN427_RS29340_lanthipeptide
2
E V Q V A S S W P C A-I V P P V L I W T I T D S A N S C P S T A C S S R C
38
E V+ S S P C A + V W S +C P+ A C S C
2
E V E T R S S L P C A G L T V A V G T W V F Q T S E K T C P T L A C S K A C
39
40.5%
NZ_NTSR01000029.1 and 1 other:
NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide
Lanthipeptides: CN358_RS25165_lanthipeptide
2
E V Q V A S S W P C A I V P P---V L I W T I T D S A N S C P S T A C S S R C
38
E V ++ P C A+ + I+T S S C P++A C S S R C
2
E V N P R T T V P C A V G G A T V G I T I Y T F D R S H Q S C P T S A C S S R C
41
39.5%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00390_lanthipeptide
Lanthipeptides: CWT12_RS00390_lanthipeptide
7
S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
S S W P C I I T + C P+ A C S S+C
5
S S W P C G I-------G I T T T V--C P T A A C S S K C
27
38.5%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide
Lanthipeptides: P40081_RS37160_lanthipeptide
7
S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
S S W P C +I + S A N C P+T C+S+C
14
S S W P C------V I G A V D I S A N L C P T T K C T S K C
39
38.5%
NZ_NTWJ01000043.1 and 1 other:
NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS31525_lanthipeptide
Lanthipeptides: CN427_RS31525_lanthipeptide
2
E V Q V A S S W P C-A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
E V+ S S P C ++ V W S +C P+ A C S C
2
E V E T R S S V P C V S L T V A V G T W V F Q T S D K T C P T L A C S K A C
39
36.8%
NC_006322.1 and 7 others:
NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide
Lanthipeptides: BLI_RS20290_lanthipeptide
7
S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
S S W C + +T S A+ C P+T C+S R C
13
S S W T C------I T A G V T V S A S L C P T T K C T S R C
38
36.8%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide
Lanthipeptides: LDO05_RS02090_lanthipeptide
7
S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38
S S W C + S A C P S T A C+S+C
7
S S W I C G V A----------S A A F C P S T A C T S K C
28

#### MIBiG 4.0 matches for KZX51_RS23840

23.7%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
25
S A N S C P S T A C S S R C
38
S A C P+T C+S R C
24
S A A F C P T T K C T S R C
37
15.8%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
29
C P S T A C S S R C
38
C P+T C+S+C
17
C P T T K C T S K C
26
KZX51_RS23855
Leader:
MSYQALKNPYSRTHNNVLPIENPLVELKEDELLKAG
Core:
G A A Q P E W V E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
Core with dehydrations:
G A A Q P E W V E V I I Dhb Dha L A Cys A A A Dha Y F M G N P G H V Cys Dhb L Dhb V E Cys Q K Dha Cys N

#### antiSMASH-DB 4.0 matches for KZX51_RS23855

100.0%
NZ_BMFU01000012.1 and 5 others:
NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25375_lanthipeptide NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptide NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide
Lanthipeptides: IEW26_RS25375_lanthipeptide
1
G A A Q P E W V E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
G A A Q P E W V E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
1
G A A Q P E W V E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
95.2%
NZ_JACHKG010000014.1 and 1 other:
NZ_JACHKG010000014.1 Lanthipeptides: allorf_027480_027638_lanthipeptide
Lanthipeptides: allorf_027480_027638_lanthipeptide
1
G A A Q P E W V E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
G A A Q P+W E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
1
G A A Q P Q W A E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
73.8%
NZ_JALIRS010000003.1 and 3 others:
NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide
Lanthipeptides: MOK21_RS07255_lanthipeptide
4
Q P E W V E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
Q W E I+T S L A C A A A S Y +G N P G H V C T L T V E C Q K C N
2
Q E R W A E T I L T S L A C A A A S Y I L G N P G H V C T L T V E C Q K K C N
40
with 98 more sequence matches
Only the first 10 are displayed here.
45.2%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide
Lanthipeptides: MT347_RS12955_lanthipeptide
12
I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
I T S L C S+ G N G V C T T V E C Q +C N
9
I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
45.2%
NZ_NTSR01000029.1 and 1 other:
NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25180_lanthipeptide
Lanthipeptides: CN358_RS25180_lanthipeptide
1
G A A Q P E W V E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
G A A+P + S S +G N G++C T T V E C Q K+C N
1
G A A E P R T I G S F-N S A D Y I K L S I G L G N N G Y I C T Y T V E C Q K N C N
41
40.5%
NZ_BMRY01000003.1 and 24 others:
NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide
Lanthipeptides: IE140_RS12370_lanthipeptide
10
V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C
41
I++S L+C A S Y +G N G+ C T T E C Q +C
6
T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C
37
40.5%
NZ_CP013862.1 and 1 other:
NZ_CP013862.1 Lanthipeptides: AOX59_RS09360_lanthipeptide
Lanthipeptides: AOX59_RS09360_lanthipeptide
9
E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
+ +T C S M G N G H+C T T V E C Q +C N
5
Q T A L T Y S T C H W I S P A M G N D G H L C T A T V E C Q P N C N
38
40.5%
NZ_CP115450.1 and 1 other:
NZ_CP115450.1 Lanthipeptides: O1G21_RS35415_lanthipeptide
Lanthipeptides: O1G21_RS35415_lanthipeptide
12
I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C
41
I L A A S+ M G N G++C T+T E C Q K+C
6
I E V L T Y T A A S W A M G N N G Y L C T V T A E C Q K N C
35
40.5%
NZ_JAQFWW010000002.1 and 1 other:
NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide
Lanthipeptides: PDT38_RS11330_lanthipeptide
11
I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
++T+L+C A A S +G+ G V C T T V E C Q +C
6
L L T T L S C L A A S I M I G D K G Q V C T G T V E C Q N N C R
37
40.5%
NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide
Lanthipeptides: BN6628_RS02285_lanthipeptide
11
I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
++T+L A C A S Y +G+ G V C T T V E C +C
6
V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R
37
38.1%
NC_006322.1 and 7 others:
NC_006322.1 Lanthipeptides: BLI_RS20295_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptide
Lanthipeptides: BLI_RS20295_lanthipeptide
12
I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
I T C A S +G N G++C T+T E C S C N
2
I T L S T C A I L S K P L G N N G Y L C T V T K E C M P S C N
32
38.1%
NZ_BMVL01000013.1 and 1 other:
NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide
Lanthipeptides: IE257_RS28650_lanthipeptide
11
I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C
41
I ++ A S+ +G N G H+C T+T V E C Q K+C
2
I F E T V T Y T V A S W A L G N N G H L C T V T V E C Q K N C
32
38.1%
NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24800_lanthipeptide
Lanthipeptides: LL065_RS24800_lanthipeptide
7
W V E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C
41
W V I+ A S Y +G N G +C T +V E C Q +C
2
W V S T I L Q G T V G C L A S Y A L G N Q G K I C T W S V E C Q N N C
36

#### MIBiG 4.0 matches for KZX51_RS23855

31.0%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
24
M G N P G H V C T L T V E C Q K S C N
42
+G N G C T L T V E C S C N
10
L G N K G A Y C T L T V E C M P S C N
28
31.0%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
19
A A S Y F M G N P G H V C T L T V E C Q K S C N
42
+ S +G N G C T L T E C Q +C N
7
S L S N A L G N N G G W C T L T K E C Q P N C N
30
19.0%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
31
C T L T V E C Q K S C N
42
C T L+ E C Q +C N
28
C T L S K E C Q P N C N
39
with 1 more sequence matches
7.1%
BGC0000503.5 (cinA):
Lanthipeptide: cinnamycin
37
C Q K S C N
42
C++S C+
1
C R Q S C S
6
allorf_051170_051277
Leader:
MLLIVHGS
Core:
P D V N L Q D E G V T A H I T A Y D V C L G K L Y F R
Core with dehydrations:
P D V N L Q D E G V Dhb A H I Dhb A Y D V Cys L G K L Y F R

#### antiSMASH-DB 4.0 matches for allorf_051170_051277

100.0%
NZ_JAHXMW010000012.1 and 1 other:
NZ_JAHXMW010000012.1 Lanthipeptides: allorf_051170_051277_lanthipeptide
Lanthipeptides: allorf_051170_051277_lanthipeptide
1
P D V N L Q D E G V T A H I T A Y D V C L G K L Y F R
27
P D V N L Q D E G V T A H I T A Y D V C L G K L Y F R
1
P D V N L Q D E G V T A H I T A Y D V C L G K L Y F R
27
22.2%
NZ_AP023438.1 and 1 other:
NZ_AP023438.1 Lanthipeptides: IGA62_RS12300_lanthipeptide
Lanthipeptides: IGA62_RS12300_lanthipeptide
7
D E G V T A H I T A Y D V C L G K
23
D+G + T + C G K
9
D D G C G S G N T G S N A C T G K
25
18.5%
NZ_JAGGRJ010000031.1:
Lanthipeptides: allorf_016614_016724_lanthipeptide
8
E G V T A H I T A Y D V C L G K L
24
+ V A +++C L G++
2
D S V R A T P P P F N L C L G R I
18
with 1 more sequence matches
14.0%
NZ_JADIKF010000040.1:
Lanthipeptides: ISS99_RS17245_lanthipeptide
14
I T A Y D V C L G K L
24
+T A Y V C G+
20
V T A Y A V C S G R C
30
allorf_051496_051735
Leader:
MCSTFAPYSRIILEPFLYEGAFMDSTGIVRAWVAGS
Core:
G D A S A S S T L K P I K R Q T T N K L R F R S L R N C V R A S N L H R P C D R I R G
Core with dehydrations:
G D A Dha A Dha Dha Dhb L K P I K R Q Dhb Dhb N K L R F R Dha L R N Cys V R A Dha N L H R P Cys D R I R G

#### antiSMASH-DB 4.0 matches for allorf_051496_051735

100.0%
NZ_JAHXMW010000012.1 and 2 others:
NZ_JAHXMW010000012.1 Lanthipeptides: allorf_051496_051735_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: allorf_139409_139648_lanthipeptide
Lanthipeptides: allorf_051496_051735_lanthipeptide
1
G D A S A S S T L K P I K R Q T T N K L R F R S L R N C V R A S N L H R P C D R I R G
43
G D A S A S S T L K P I K R Q T T N K L R F R S L R N C V R A S N L H R P C D R I R G
1
G D A S A S S T L K P I K R Q T T N K L R F R S L R N C V R A S N L H R P C D R I R G
43
97.7%
NZ_JACHKG010000014.1:
Lanthipeptides: allorf_017085_017312_lanthipeptide
1
G D A S A S S T L K P I K R Q T T N K L R F R S L R N C V R A S N L H R P C D R I R G
43
G D A S A S T L K P I K R Q T T N K L R F R S L R N C V R A S N L H R P C D R I R G
1
G D A S A L S T L K P I K R Q T T N K L R F R S L R N C V R A S N L H R P C D R I R G
43
13.0%
NZ_CP008953.1 and 1 other:
NZ_JPLW01000002.1 Lanthipeptides: allorf_1064250_1064342_lanthipeptide
Lanthipeptides: allorf_3865033_3865224_lanthipeptide
31
A S N L H R P C D R I
41
A S N H R P C +
35
A S N G H R P C P A V
45
allorf_051732_051842
Leader:
MMSPEYRPVTGYTLGQPDCLLQHTPGG
Core:
D V T A Y P T T C
Core with dehydrations:
D V Dhb A Y P Dhb Dhb Cys

#### antiSMASH-DB 4.0 matches for allorf_051732_051842

100.0%
NZ_JACHKG010000014.1 and 3 others:
NZ_JAHXMW010000012.1 Lanthipeptides: allorf_051732_051842_lanthipeptide NZ_JAHXMW010000012.1 Lanthipeptides: allorf_051732_051842_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: allorf_139302_139412_lanthipeptide
Lanthipeptides: allorf_017309_017419_lanthipeptide
1
D V T A Y P T T C
9
D V T A Y P T T C
1
D V T A Y P T T C
9
allorf_051847_052008
Leader:
MTTPVEAYVSLSSDRGSTPLASISSIRRSTLMGA
Core:
F F L C S Y I T S D D S L Y R L W T I
Core with dehydrations:
F F L Cys Dha Y I Dhb Dha D D Dha L Y R L W Dhb I

#### antiSMASH-DB 4.0 matches for allorf_051847_052008

100.0%
NZ_JAHXMW010000012.1 and 2 others:
NZ_JAHXMW010000012.1 Lanthipeptides: allorf_051847_052008_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: allorf_139136_139297_lanthipeptide
Lanthipeptides: allorf_051847_052008_lanthipeptide
1
F F L C S Y I T S D D S L Y R L W T I
19
F F L C S Y I T S D D S L Y R L W T I
1
F F L C S Y I T S D D S L Y R L W T I
19
31.6%
NZ_RKNR01000012.1:
Lanthipeptides: allorf_004148_004249_lanthipeptide
1
F F L C S Y I T S
9
F F L C+Y+ S
7
F F L C T Y V P S
15
17.1%
NC_017943.1:
Lanthipeptides: allorf_132120_132308_lanthipeptide
2
F L C S Y I T S D D S L Y R
15
L C T S+D L R
18
L L C D L T T S E D E L V R
31
with 2 more sequence matches
16.2%
NZ_FOJF01000001.1:
Lanthipeptides: BMW86_RS13610_lanthipeptide
7
I T S D D S L Y R L W T
18
+ D D++ R L W T
2
V G G D D T I T R L W T
13
15.8%
NZ_FNUH01000004.1 and 1 other:
NZ_FOGM01000011.1 Lanthipeptides: allorf_16865_17017_lanthipeptide
Lanthipeptides: allorf_021870_022022_lanthipeptide
1
F F L C S Y I T S D D S L Y R L W T I
19
F L C+Y I + ++ + T+
13
F L L C T Y I V N S K T I K K H L T V
31
allorf_051923_052081
Leader:
MLFCIKPNFLKQMFSS
Core:
K I L Y V Y N F L I L S K V C K E S R Q M L Y K N K E K K H P S R C F F
Core with dehydrations:
K I L Y V Y N F L I L Dha K V Cys K E Dha R Q M L Y K N K E K K H P Dha R Cys F F

#### antiSMASH-DB 4.0 matches for allorf_051923_052081

100.0%
NZ_JAHXMW010000012.1 and 2 others:
NZ_JAHXMW010000012.1 Lanthipeptides: allorf_051923_052081_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: allorf_139063_139221_lanthipeptide
Lanthipeptides: allorf_051923_052081_lanthipeptide
1
K I L Y V Y N F L I L S K V C K E S R Q M L Y K N K E K K H P S R C F F
36
K I L Y V Y N F L I L S K V C K E S R Q M L Y K N K E K K H P S R C F F
1
K I L Y V Y N F L I L S K V C K E S R Q M L Y K N K E K K H P S R C F F
36
11.9%
NZ_OCTY01000002.1:
Lanthipeptides: allorf_0873960_0874184_lanthipeptide
21
M L Y K N K E K K H P S R C
34
+L Y + + P+R C
22
L L Y T S P R P R D P T R C
35
allorf_053850_054050
Leader:
MNLKKLSLVWCNSLDKMLLLLAPIFVITAESSETHYVSGM
Core:
D Q S K G W N K A Y V G N S L L N C C P S T L N S L
Core with dehydrations:
D Q Dha K G W N K A Y V G N Dha L L N Cys Cys P Dha Dhb L N Dha L

#### antiSMASH-DB 4.0 matches for allorf_053850_054050

100.0%
NZ_JAHXMW010000012.1 and 1 other:
NZ_JAHXMW010000012.1 Lanthipeptides: allorf_053850_054050_lanthipeptide
Lanthipeptides: allorf_053850_054050_lanthipeptide
1
D Q S K G W N K A Y V G N S L L N C C P S T L N S L
26
D Q S K G W N K A Y V G N S L L N C C P S T L N S L
1
D Q S K G W N K A Y V G N S L L N C C P S T L N S L
26
88.5%
NZ_BMFU01000012.1 and 1 other:
NZ_BMFU01000012.1 Lanthipeptides: allorf_066510_066707_lanthipeptide
Lanthipeptides: allorf_066510_066707_lanthipeptide
1
D Q S K G W N K A Y V G N S L L N C C P S T L N S L
26
D Q S G W N K A V G N S L N C C P S T L N S L
1
D Q S T G W N K A C V G N S R L N C C P S T L N S L
26
84.6%
NZ_VDYW01000008.1:
Lanthipeptides: allorf_137107_137307_lanthipeptide
1
D Q S K G W N K A Y V G N S L L N C C P S T L N S L
26
D S K G W N K A Y V G+ L L N C C P S T N S L
1
D H S K G W N K A Y V G D I L L N C C P S T H N S L
26
with 2 more sequence matches
80.8%
NZ_JACHKG010000014.1 and 1 other:
NZ_JACHKG010000014.1 Lanthipeptides: allorf_020828_021025_lanthipeptide
Lanthipeptides: allorf_020828_021025_lanthipeptide
1
D Q S K G W N K A Y V G N S L L N C C P S T L N S L
26
D Q S G W N K A V G N S L N C C P S T +S L
1
D Q S T G W N K A C V G N S R L N C C P S T H S S L
26
25.0%
NZ_CP029607.1:
Lanthipeptides: allorf_6474235_6474408_lanthipeptide
3
S K G W N K A Y V G N S L L N C C P S T
22
+G W S L N C P T
2
G R G W E A G V G E R S L P N A C P R T
21
allorf_064022_064084
Leader:
MIVVLTSHSLLYS
Core:
N C K L S P T
Core with dehydrations:
N Cys K L Dha P Dhb

#### antiSMASH-DB 4.0 matches for allorf_064022_064084

100.0%
NZ_JAHXMW010000012.1 and 1 other:
NZ_JAHXMW010000012.1 Lanthipeptides: allorf_064022_064084_lanthipeptide
Lanthipeptides: allorf_064022_064084_lanthipeptide
1
N C K L S P T
7
N C K L S P T
1
N C K L S P T
7
85.7%
NZ_VDYW01000008.1:
Lanthipeptides: allorf_127072_127134_lanthipeptide
1
N C K L S P T
7
N C K S P T
1
N C K S S P T
7
allorf_069857_070018
Leader:
MSDVHFYMVRVVFYA
Core:
V Q C K F I H S L W K S P S L P A L Y Q N K P A K A I K T V E V L R A S S I
Core with dehydrations:
V Q Cys K F I H Dha L W K Dha P Dha L P A L Y Q N K P A K A I K Dhb V E V L R A Dha Dha I

#### antiSMASH-DB 4.0 matches for allorf_069857_070018

100.0%
NZ_JAHXMW010000012.1:
Lanthipeptides: allorf_069857_070018_lanthipeptide
1
V Q C K F I H S L W K S P S L P A L Y Q N K P A K A I K T V E V L R A S S I
38
V Q C K F I H S L W K S P S L P A L Y Q N K P A K A I K T V E V L R A S S I
1
V Q C K F I H S L W K S P S L P A L Y Q N K P A K A I K T V E V L R A S S I
38
15.8%
NZ_JAHFVJ010000001.1:
Lanthipeptides: allorf_617019_617141_lanthipeptide
3
C K F I H S L W K S P S L P A
17
C K F + K+P++P
4
C K F R P T D G K T P A M P G
18

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.23 out of 26.06
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.13 out of 20.97
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.58 out of 20.97
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.15 out of 18.46
Confidence: medium
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 27.21 out of 33.14
Confidence: medium
Additional weak hits (9):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.97 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.18 out of 28.14
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.48 out of 21.55
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.25 out of 30.97
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.13 out of 29.65
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.42 out of 33.14
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.13 out of 29.65
Confidence: weak
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.02 out of 29.72
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.76 out of 26.06
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

KZX51_RS23840 - Class II
  Cleavage pHMM score: 1.20
  RODEO score: 0
  Monoisotopic mass: 3780.9 Da
  Molecular weight: 3783.3 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3801.3 Da N = 1
    3819.3 Da N = 2
    3837.3 Da N = 3
    3855.4 Da N = 4
    3873.4 Da N = 5
    3891.4 Da N = 6
    3909.4 Da N = 7
KZX51_RS23855 - Class II
  Cleavage pHMM score: -4.80
  RODEO score: 0
  Monoisotopic mass: 4290.0 Da
  Molecular weight: 4292.9 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4310.9 Da N = 1
    4328.9 Da N = 2
allorf_051170_051277 - Class II
  Cleavage pHMM score: -6.70
  RODEO score: 0
  Monoisotopic mass: 3000.5 Da
  Molecular weight: 3002.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3020.4 Da N = 1
allorf_051496_051735 - Class II
  Cleavage pHMM score: -6.60
  RODEO score: 0
  Monoisotopic mass: 4734.6 Da
  Molecular weight: 4737.4 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4755.4 Da N = 1
    4773.5 Da N = 2
    4791.5 Da N = 3
    4809.5 Da N = 4
    4827.5 Da N = 5
    4845.5 Da N = 6
allorf_051732_051842 - Class II
  Cleavage pHMM score: -7.10
  RODEO score: 0
  Monoisotopic mass: 915.4 Da
  Molecular weight: 916.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    934.0 Da N = 1
    952.0 Da N = 2
allorf_051847_052008 - Class II
  Cleavage pHMM score: -1.60
  RODEO score: 0
  Monoisotopic mass: 2252.1 Da
  Molecular weight: 2253.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2271.6 Da N = 1
    2289.6 Da N = 2
    2307.6 Da N = 3
    2325.6 Da N = 4
allorf_051923_052081 - Class II
  Cleavage pHMM score: -6.30
  RODEO score: 0
  Monoisotopic mass: 4426.4 Da
  Molecular weight: 4429.3 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4447.3 Da N = 1
allorf_053850_054050 - Class II
  Cleavage pHMM score: -4.10
  RODEO score: 0
  Monoisotopic mass: 2721.3 Da
  Molecular weight: 2723.0 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2741.0 Da N = 1
    2759.1 Da N = 2
    2777.1 Da N = 3
allorf_064022_064084 - Class II
  Cleavage pHMM score: -7.10
  RODEO score: 0
  Monoisotopic mass: 725.4 Da
  Molecular weight: 725.8 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    743.9 Da N = 1
allorf_069857_070018 - Class II
  Cleavage pHMM score: -6.00
  RODEO score: 0
  Monoisotopic mass: 4142.4 Da
  Molecular weight: 4144.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4162.9 Da N = 1
    4180.9 Da N = 2
    4199.0 Da N = 3
    4217.0 Da N = 4
    4235.0 Da N = 5
KZX51_RS23840 - Class II
  Cleavage pHMM score: 1.20
  RODEO score: 0
  Monoisotopic mass: 3780.9 Da
  Molecular weight: 3783.3 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3801.3 Da N = 1
    3819.3 Da N = 2
    3837.3 Da N = 3
    3855.4 Da N = 4
    3873.4 Da N = 5
    3891.4 Da N = 6
    3909.4 Da N = 7
KZX51_RS23855 - Class II
  Cleavage pHMM score: -4.80
  RODEO score: 0
  Monoisotopic mass: 4290.0 Da
  Molecular weight: 4292.9 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4310.9 Da N = 1
    4328.9 Da N = 2
allorf_047087_047290 - Class II
  Cleavage pHMM score: -6.40
  RODEO score: 0
  Monoisotopic mass: 6024.1 Da
  Molecular weight: 6028.0 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    6046.0 Da N = 1
    6064.1 Da N = 2
    6082.1 Da N = 3
    6100.1 Da N = 4
    6118.1 Da N = 5
    6136.1 Da N = 6
allorf_051170_051277 - Class II
  Cleavage pHMM score: -6.70
  RODEO score: 0
  Monoisotopic mass: 3000.5 Da
  Molecular weight: 3002.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3020.4 Da N = 1
allorf_051496_051735 - Class II
  Cleavage pHMM score: -6.60
  RODEO score: 0
  Monoisotopic mass: 4734.6 Da
  Molecular weight: 4737.4 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4755.4 Da N = 1
    4773.5 Da N = 2
    4791.5 Da N = 3
    4809.5 Da N = 4
    4827.5 Da N = 5
    4845.5 Da N = 6
allorf_051732_051842 - Class II
  Cleavage pHMM score: -7.10
  RODEO score: 0
  Monoisotopic mass: 915.4 Da
  Molecular weight: 916.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    934.0 Da N = 1
    952.0 Da N = 2
allorf_051847_052008 - Class II
  Cleavage pHMM score: -1.60
  RODEO score: 0
  Monoisotopic mass: 2252.1 Da
  Molecular weight: 2253.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2271.6 Da N = 1
    2289.6 Da N = 2
    2307.6 Da N = 3
    2325.6 Da N = 4
allorf_051923_052081 - Class II
  Cleavage pHMM score: -6.30
  RODEO score: 0
  Monoisotopic mass: 4426.4 Da
  Molecular weight: 4429.3 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4447.3 Da N = 1
allorf_053850_054050 - Class II
  Cleavage pHMM score: -4.10
  RODEO score: 0
  Monoisotopic mass: 2721.3 Da
  Molecular weight: 2723.0 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2741.0 Da N = 1
    2759.1 Da N = 2
    2777.1 Da N = 3
allorf_064022_064084 - Class II
  Cleavage pHMM score: -7.10
  RODEO score: 0
  Monoisotopic mass: 725.4 Da
  Molecular weight: 725.8 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    743.9 Da N = 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis
VqsM | Regulator of quorum-sensing signalling systems
ZuR variant 2 | Zinc-responsive repressor

NZ_JAHXMW010000013.1 - Region 1 - proteusin
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 56,874 - 77,134 nt. (total: 20,261 nt) Show pHMM detection rules used
proteusin: (PoyD or TIGR03793)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
KZX51_RS24610: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase
KZX51_RS24670: acyltransferase 3

smcogs
  SMCOG1088: acyltransferase 3

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | proteusin | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.5 |  | 0.49 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001928.2 |  | 0.48 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001184.4 |  | 0.44 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000894.4 |  | 0.41 | other (other) | citrinin | Monascus aurantiacus
BGC0002496.3 |  | 0.39 | NRPS | serratiochelin A, serratiochelin C, serratiochelin B | Serratia plymuthica
BGC0001197.5 |  | 0.37 | PKS | frankiamicin | Frankia sp. EAN1pec
BGC0000671.3 |  | 0.36 | terpene | momilactone B | Oryza sativa Japonica Group
BGC0000384.6 |  | 0.36 | NRPS | lyngbyatoxin | Lyngbya majuscula
BGC0000313.4 |  | 0.35 | NRPS | beauvericin | Beauveria bassiana
BGC0001605.3 |  | 0.35 | terpene | gibberellin | Sinorhizobium fredii NGR234

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.5 |  | 0.49 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001928.2 |  | 0.48 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001184.4 |  | 0.44 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000894.4 |  | 0.41 | other (other) | citrinin | Monascus aurantiacus
BGC0002496.3 |  | 0.39 | NRPS | serratiochelin A, serratiochelin C, serratiochelin B | Serratia plymuthica
BGC0001197.5 |  | 0.37 | PKS | frankiamicin | Frankia sp. EAN1pec
BGC0000671.3 |  | 0.36 | terpene | momilactone B | Oryza sativa Japonica Group
BGC0000384.6 |  | 0.36 | NRPS | lyngbyatoxin | Lyngbya majuscula
BGC0000313.4 |  | 0.35 | NRPS | beauvericin | Beauveria bassiana
BGC0001605.3 |  | 0.35 | terpene | gibberellin | Sinorhizobium fredii NGR234

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.11 out of 20.97
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.71 out of 23.79
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.01 out of 30.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.70 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.39 out of 28.19
Confidence: medium
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52
Confidence: strong
Additional weak hits (6):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.65 out of 29.38
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.39 out of 28.14
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.79 out of 31.73
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.03 out of 33.14
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.40 out of 32.93
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.35 out of 28.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
IolR | Regulator of the inositol catabolism
ZuR variant 1 | Zinc-responsive repressor

NZ_JAHXMW010000014.1 - Region 1 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 27,453 - 63,207 nt. (total: 35,755 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
KZX51_RS25360: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

Hydrolases: glucosidase
KZX51_RS25395: Alpha-glucosidase

smcogs
  SMCOG1257: Alpha-glucosidase

Lyases: decarboxylase
KZX51_RS25335: diaminopimelate decarboxylase

smcogs
  SMCOG1264: diaminopimelate decarboxylase

Ligases: ligase
KZX51_RS25400: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000946.5 |  | 0.59 | other (other) | vibrioferrin | Vibrio parahaemolyticus
BGC0000942.4 |  | 0.59 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0000943.5 |  | 0.58 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002471.3 |  | 0.56 | other (other) | baumannoferrin A, baumannoferrin B | Acinetobacter baumannii AYE
BGC0002682.2 |  | 0.56 | other (other) | aerobactin | Vibrio mimicus
BGC0001870.3 |  | 0.55 | other (other) | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0002073.3 |  | 0.55 | NRPS | dehydroxynocardamine | Corynebacterium propinquum
BGC0000947.5 |  | 0.54 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0001572.3 |  | 0.52 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0000939.5 |  | 0.51 | other (other) | aerobactin | Grimontia hollisae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000946.5 |  | 0.59 | other (other) | vibrioferrin | Vibrio parahaemolyticus
BGC0000942.4 |  | 0.59 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0000943.5 |  | 0.58 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002471.3 |  | 0.56 | other (other) | baumannoferrin A, baumannoferrin B | Acinetobacter baumannii AYE
BGC0002682.2 |  | 0.56 | other (other) | aerobactin | Vibrio mimicus
BGC0001870.3 |  | 0.55 | other (other) | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0002073.3 |  | 0.55 | NRPS | dehydroxynocardamine | Corynebacterium propinquum
BGC0000947.5 |  | 0.54 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0001572.3 |  | 0.52 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0000939.5 |  | 0.51 | other (other) | aerobactin | Grimontia hollisae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.06 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.23 out of 26.06
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.15 out of 20.97
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.68 out of 20.97
Confidence: strong
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.75 out of 25.88
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.11 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.60 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.54 out of 29.38
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.19 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.81 out of 28.19
Confidence: medium
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.75 out of 33.14
Confidence: medium
Additional weak hits (11):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.65 out of 29.38
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.14 out of 31.73
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.83 out of 26.12
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.99 out of 32.74
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.15 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.33 out of 29.38
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.87 out of 32.93
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.41 out of 26.06
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
PsrA | Oleic acid responsive regulator
ZuR variant 1 | Zinc-responsive repressor
ZuR variant 2 | Zinc-responsive repressor

NZ_JAHXMW010000002.1 - Region 1 - phosphonate
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 331,963 - 354,005 nt. (total: 22,043 nt) Show pHMM detection rules used
phosphonate: (phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase or phosphonatesMeIsocitrateLyase))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
KZX51_RS10305: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

Transferases: aminotransferase
KZX51_RS10295: aminotransferase class V

smcogs
  SMCOG1139: aminotransferase class V

Ligases: synthase
KZX51_RS10245: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | phosphonate | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000926.5 |  | 0.54 | other (other) | rhizocticin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001739.3 |  | 0.48 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0000904.5 |  | 0.48 | other (other) | FR-900098 | Streptomyces rubellomurinus
BGC0002036.4 |  | 0.47 | other (other) | dehydrofosmidomycin | Streptomyces lavendulae
BGC0001859.4 |  | 0.46 | other (phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000897.5 |  | 0.44 | other (other) | dehydrophos | Streptomyces luridus
BGC0000937.5 |  | 0.43 | other (other) | fosfazinomycin A, fosfazinomycin B | Streptomyces sp. WM6372
BGC0000938.5 |  | 0.42 | other (aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0002670.2 |  | 0.41 | other (other) | fosfonochlorin | Fusarium oxysporum f. sp. lycopersici 4287
BGC0000807.3 |  | 0.38 | saccharide | phosphonoglycans | Stackebrandtia nassauensis DSM 44728

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000926.5 |  | 0.54 | other (other) | rhizocticin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001739.3 |  | 0.48 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0000904.5 |  | 0.48 | other (other) | FR-900098 | Streptomyces rubellomurinus
BGC0002036.4 |  | 0.47 | other (other) | dehydrofosmidomycin | Streptomyces lavendulae
BGC0001859.4 |  | 0.46 | other (phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000897.5 |  | 0.44 | other (other) | dehydrophos | Streptomyces luridus
BGC0000937.5 |  | 0.43 | other (other) | fosfazinomycin A, fosfazinomycin B | Streptomyces sp. WM6372
BGC0000938.5 |  | 0.42 | other (aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0002670.2 |  | 0.41 | other (other) | fosfonochlorin | Fusarium oxysporum f. sp. lycopersici 4287
BGC0000807.3 |  | 0.38 | saccharide | phosphonoglycans | Stackebrandtia nassauensis DSM 44728

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.15 out of 26.06
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.84 out of 23.79
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.12 out of 28.19
Confidence: medium
Additional weak hits (5):
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.70 out of 21.55
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.86 out of 26.85
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.49 out of 21.55
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.21 out of 29.65
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
IolR | Regulator of the inositol catabolism
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_JAHXMW010000002.1 - Region 2 - NRPS,T1PKS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 414,760 - 478,037 nt. (total: 63,278 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
KZX51_RS10725: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

KZX51_RS10740: 3-hydroxybutyryl-CoA dehydrogenase

smcogs
  SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

Transferases: acylase aminotransferase
KZX51_RS10730: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

KZX51_RS10735: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

Hydrolases: esterase phosphatase
KZX51_RS10745: FkbH like protein

smcogs
  SMCOG1256: FkbH like protein

KZX51_RS10760: thioesterase

smcogs
  SMCOG1004: thioesterase

Ligases: ligase synthase
KZX51_RS10710: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

KZX51_RS10715: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Translocases: transporter
KZX51_RS10795: sugar-binding lipoprotein

smcogs
  SMCOG1143: sugar-binding lipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | NRPS | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0001132.4 |  |  |  | 1.07 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  |  |  | 1.02 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  |  |  | 0.97 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.4 |  |  |  | 0.92 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002191.2 |  |  |  | 0.81 | PKS | prolipyrone B, gibepyrone D | Fusarium graminearum PH-1
BGC0001275.3 |  |  |  | 0.80 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001164.3 |  |  |  | 0.80 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001160.5 |  |  |  | 0.80 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001276.3 |  |  |  | 0.79 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001273.3 |  |  |  | 0.79 | PKS | asperlactone | Aspergillus ochraceus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001132.4 |  | 0.69 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  | 0.67 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.66 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.4 |  | 0.64 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002191.2 |  | 0.60 | PKS | prolipyrone B, gibepyrone D | Fusarium graminearum PH-1
BGC0001275.3 |  | 0.60 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001164.3 |  | 0.60 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001160.5 |  | 0.60 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001276.3 |  | 0.60 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001273.3 |  | 0.60 | PKS | asperlactone | Aspergillus ochraceus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.87 out of 20.97
Confidence: strong
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.56 out of 29.25
Confidence: medium
Additional weak hits (7):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.04 out of 30.25
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.25 out of 30.97
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.04 out of 29.65
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.86 out of 29.65
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.10 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.63 out of 26.12
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 414759 - 478037:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - mal - Gly - Val) + (fatty_acid - mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KZX51_RS10710: X - mal - Gly - Val
Search NORINE for peptide: strict or relaxed
AMP-binding (461..866): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    TDLTFDVSCTEGNFFVGGEENVYGPTECTIWVSH
  Nearest Stachelhaus code(s):
    Ala DVTNFALIYK (71% 8Å match)
    Gly DILQFGVIWK (62% 8Å match)
  Stachelhaus code match:
    70% (weak)

PKS_AT (1587..1884): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 87.5%
  inactive: 83.3%
  2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 129.3
  inactive: 76.2
  Methoxymalonyl-CoA: 56.5
  Methylmalonyl-CoA: 49.1
  Propionyl-CoA: 37.5
  Ethylmalonyl-CoA: 25.9
  Isobutyryl-CoA: 19.8
  fatty_acid: 11.9
  CHC-CoA: 11.3
  2-Methylbutyryl-CoA: 10.7
  Acetyl-CoA: 8.1
  trans-1,2-CPDA: 0.0
  Benzoyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

AMP-binding (2525..2919): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FDITFDIFGFEALSLTGGEFNMYGPTETTIWSTT
  Nearest Stachelhaus code(s):
    Gly DILQLGMIWK (68% 8Å match)
  Stachelhaus code match:
    80% (moderate)

AMP-binding (4521..4921): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    VKSSFDGSIFDAFIMFGGELNGYGPTEATFFASY
  Nearest Stachelhaus code(s):
    Val DGFFVGGVFK (65% 8Å match)
  Stachelhaus code match:
    80% (moderate)

KZX51_RS10715: fatty_acid
CAL_domain (173..480): fatty_acid
minowa: fatty_acid

Prediction, score:
  fatty_acid: 65.8
  NH2: 32.8
  shikimic_acid: 0.0
  Acetyl-CoA: 0.0
  AHBA: 0.0

KZX51_RS10730: mal
PKS_AT (5..290): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 63.6
  Methoxymalonyl-CoA: 48.8
  Methylmalonyl-CoA: 41.4
  Ethylmalonyl-CoA: 25.3
  CHC-CoA: 18.6
  trans-1,2-CPDA: 16.5
  inactive: 14.9
  Propionyl-CoA: 12.6
  2-Methylbutyryl-CoA: 12.0
  fatty_acid: 10.9
  Benzoyl-CoA: 10.2
  Acetyl-CoA: 3.6
  Isobutyryl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
SypG | Regulator of biofilm formation and host colonization

NZ_JAHXMW010000020.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 53,738 nt. (total: 53,738 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
KZX51_RS28285: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

KZX51_RS28290: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: aminotransferase
KZX51_RS28200: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

Ligases: ligase
KZX51_RS28205: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Translocases: permease
KZX51_RS28235: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

KZX51_RS28245: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.72 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001166.5 |  | 0.70 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001833.4 |  | 0.69 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.69 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.68 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.68 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0000307.4 |  | 0.67 | NRPS | AbT1 | Aureobasidium pullulans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.72 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001166.5 |  | 0.70 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001833.4 |  | 0.69 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.69 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.68 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.68 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0000307.4 |  | 0.67 | NRPS | AbT1 | Aureobasidium pullulans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.75 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.48 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.72 out of 27.78
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.28 out of 26.33
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.38 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.90 out of 26.06
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.41 out of 28.19
Confidence: strong
Additional weak hits (13):
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.45 out of 21.55
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.39 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.05 out of 29.38
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.02 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.32 out of 26.06
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.04 out of 31.73
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.86 out of 30.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.31 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.29 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.52 out of 26.06
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.78 out of 30.22
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.13 out of 33.14
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.77 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 53738:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-Leu - Leu - Dab - Dab - Dab)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KZX51_RS28205: Leu - Leu - Dab - Dab - Dab
Search NORINE for peptide: strict or relaxed
AMP-binding (279..668): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
  Small clusters prediction:
    Unpolar aromatic ring (Phe, Trp)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LMFAFDASCWEKILVTGGSFNAYGPTEASIVTTL
  Nearest Stachelhaus code(s):
    Leu DAWIVGAIVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1785..2184): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    ile (Ile)

Stachelhaus prediction details:
  Stachelhaus sequence:
    INTSFDGAIFDGLILFGGENHLYGPSESTVYTTY
  Nearest Stachelhaus code(s):
    Leu DGFLLGLVYK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2826..3253): Dab
nrpys: Dab

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    Orn and hydroxy-Orn specific (Orn, OH-Orn)
  Single AA prediction:
    orn (Orn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TGYAFDVFVGDRESITSSDINAYGVTEAAIDSSF
  Nearest Stachelhaus code(s):
    Dab DVGEISAIDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (3898..4325): Dab
nrpys: Dab

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    Orn and hydroxy-Orn specific (Orn, OH-Orn)
  Single AA prediction:
    orn (Orn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TGYAFDVFVGDRESITSSDINAYGVTEAAIDSSF
  Nearest Stachelhaus code(s):
    Dab DVGEISAIDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (4965..5392): Dab
nrpys: Dab

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    Orn and hydroxy-Orn specific (Orn, OH-Orn)
  Single AA prediction:
    orn (Orn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TGYAFDVFVGDRESITSSDINAYGVTEAAIDSSF
  Nearest Stachelhaus code(s):
    Dab DVGEISAIDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_JAHXMW010000027.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 26,194 nt. (total: 26,194 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: ligase
KZX51_RS30230: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

KZX51_RS30235: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001153.5 |  | 0.77 | NRPS | polymyxin B | Paenibacillus polymyxa
BGC0000408.5 |  | 0.77 | NRPS | polymyxin | Paenibacillus polymyxa
BGC0001192.5 |  | 0.77 | NRPS | colistin A, colistin B | Paenibacillus alvei
BGC0002653.2 |  | 0.76 | NRPS | macolacin | Paenibacillus xylanexedens
BGC0001833.4 |  | 0.76 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.74 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0002286.3 |  | 0.73 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001153.5 |  | 0.77 | NRPS | polymyxin B | Paenibacillus polymyxa
BGC0000408.5 |  | 0.77 | NRPS | polymyxin | Paenibacillus polymyxa
BGC0001192.5 |  | 0.77 | NRPS | colistin A, colistin B | Paenibacillus alvei
BGC0002653.2 |  | 0.76 | NRPS | macolacin | Paenibacillus xylanexedens
BGC0001833.4 |  | 0.76 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.74 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0002286.3 |  | 0.73 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 26194:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Dab - Thr) + (Dab - Thr - D-Dab)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KZX51_RS30230: Dab
Search NORINE for peptide: strict or relaxed
AMP-binding (768..1195): Dab
nrpys: Dab

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    Orn and hydroxy-Orn specific (Orn, OH-Orn)
  Single AA prediction:
    orn (Orn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TGYAFDVFVGDRESITSSDINAYGVTEAAIDSSF
  Nearest Stachelhaus code(s):
    Dab DVGEISAIDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

KZX51_RS30235: Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (269..677): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNDHFDFSVWEGNQIFGGEINMYGITETTVHVTY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

KZX51_RS30250: Dab - Thr - Dab - Dab
Search NORINE for peptide: strict or relaxed
AMP-binding (468..880): Dab
nrpys: Dab

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    Orn and hydroxy-Orn specific (Orn, OH-Orn)
  Single AA prediction:
    orn (Orn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TAYAFDVFVGDRESITSSDINSYGVTEAAIDSSF
  Nearest Stachelhaus code(s):
    Dab DVGEISSIDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1522..1930): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNDHFDFSVWEGNQIFGGEINMYGITETTVHVTY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2591..3047): Dab
nrpys: Dab

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    Orn and hydroxy-Orn specific (Orn, OH-Orn)
  Single AA prediction:
    orn (Orn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TGYAFDVFVGDRESITSSDINSYGVTEAAIDSSF
  Nearest Stachelhaus code(s):
    Dab DVGEISSIDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (4166..4524): Dab
nrpys: Dab

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    Orn and hydroxy-Orn specific (Orn, OH-Orn)
  Single AA prediction:
    orn (Orn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TGYAFDVFVGDRESITSSDINAYGVTEAAIDSSF
  Nearest Stachelhaus code(s):
    Dab DVGEISAIDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
NZ_JAHXMW010000003.1 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 168,035 - 188,907 nt. (total: 20,873 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
KZX51_RS12945: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

KZX51_RS12970: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

KZX51_RS12975: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

Ligases: synthase
KZX51_RS12950: polyprenol-monophosphomannose synthase ppm1

smcogs
  SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000645.3 |  | 0.57 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000656.5 |  | 0.47 | terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000640.3 |  | 0.45 | terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000642.3 |  | 0.43 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000635.3 |  | 0.42 | terpene | carotenoid | Paracoccus sp. N81106
BGC0000664.5 |  | 0.42 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000646.5 |  | 0.42 | terpene | β-carotein | uncultured bacterium
BGC0000638.3 |  | 0.41 | terpene | carotenoid | Pantoea ananatis
BGC0000634.3 |  | 0.40 | terpene | carotenoid | Brevundimonas sp. SD212
BGC0000641.3 |  | 0.40 | terpene | carotenoid | Enterobacteriaceae bacterium DC416

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000645.3 |  | 0.57 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000656.5 |  | 0.47 | terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000640.3 |  | 0.45 | terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000642.3 |  | 0.43 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000635.3 |  | 0.42 | terpene | carotenoid | Paracoccus sp. N81106
BGC0000664.5 |  | 0.42 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000646.5 |  | 0.42 | terpene | β-carotein | uncultured bacterium
BGC0000638.3 |  | 0.41 | terpene | carotenoid | Pantoea ananatis
BGC0000634.3 |  | 0.40 | terpene | carotenoid | Brevundimonas sp. SD212
BGC0000641.3 |  | 0.40 | terpene | carotenoid | Enterobacteriaceae bacterium DC416

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none

Genes with terpene domains:
KZX51_RS12965: PT_phytoene_like
Domain 1 (7 - 274): Prenyltransferase; Phytoene synthase like
Subtype: Diapophytoene synthase

Reactions:
  FPP → diapophytoene

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 20.76 out of 21.84
Confidence: strong
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.54 out of 23.79
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.19 out of 19.26
Confidence: medium
Additional weak hits (8):
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.96 out of 35.63
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.99 out of 20.01
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.39 out of 26.85
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.51 out of 36.54
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.51 out of 24.78
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.23 out of 26.85
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.95 out of 25.88
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
IolR | Regulator of the inositol catabolism
MexT | Global virulence regulator
ToxT | Regulator of MSHA biosynthesis

NZ_JAHXMW010000005.1 - Region 1 - NRPS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 159,205 - 222,513 nt. (total: 63,309 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
KZX51_RS16820: 3-hydroxyisobutyrate dehydrogenase

smcogs
  SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

KZX51_RS16930: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

Transferases: acylase acyltransferase aminotransferase phosphotransferase
KZX51_RS16850: acyltransferase 3

smcogs
  SMCOG1088: acyltransferase 3

KZX51_RS16870: Glucose-specific phosphotransferase enzyme IIA

smcogs
  SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

KZX51_RS16905: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

KZX51_RS16935: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

Hydrolases: hydrolase protease
KZX51_RS16885: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

KZX51_RS16900: hydrolase

smcogs
  SMCOG1179: hydrolase

KZX51_RS16925: HAD-superfamily hydrolase, subfamily IA, variant

smcogs
  SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Ligases: ligase synthase
KZX51_RS16910: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

KZX51_RS16915: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

KZX51_RS16945: Pseudouridine synthase

smcogs
  SMCOG1154: Pseudouridine synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002135.2 |  |  | 0.68 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001261.3 |  |  | 0.66 | NRPS | AM-toxin | Alternaria alternata
BGC0001133.4 |  |  | 0.65 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  |  | 0.65 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001825.4 |  |  | 0.63 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0000402.4 |  |  | 0.63 | NRPS | paenilarvin A, paenilarvin B, paenilarvin C | Paenibacillus larvae subsp. larvae DSM 25430
BGC0000307.4 |  |  | 0.62 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001132.4 |  |  | 0.62 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  | 0.61 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001758.4 |  |  | 0.61 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.67 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001261.3 |  | 0.66 | NRPS | AM-toxin | Alternaria alternata
BGC0001133.4 |  | 0.66 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.66 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001825.4 |  | 0.65 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0000402.4 |  | 0.65 | NRPS | paenilarvin A, paenilarvin B, paenilarvin C | Paenibacillus larvae subsp. larvae DSM 25430
BGC0000307.4 |  | 0.64 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001132.4 |  | 0.64 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.64 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001758.4 |  | 0.64 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.57 out of 26.33
Confidence: medium
Additional weak hits (6):
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.05 out of 33.73
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.39 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.49 out of 26.06
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.30 out of 32.93
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.55 out of 35.63
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.40 out of 20.01
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 159204 - 222513:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (fatty_acid - mal - Glu - D-Tyr) + (D-Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KZX51_RS16905: mal
PKS_AT (6..291): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 71.2
  Methoxymalonyl-CoA: 32.5
  inactive: 28.0
  Propionyl-CoA: 16.7
  Methylmalonyl-CoA: 15.6
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

KZX51_RS16910: fatty_acid - Glu
Search NORINE for peptide: strict or relaxed
CAL_domain (36..479): fatty_acid
minowa: fatty_acid

Prediction, score:
  fatty_acid: 389.3
  NH2: 26.8
  shikimic_acid: 0.0
  Acetyl-CoA: 0.0
  AHBA: 0.0

AMP-binding (2949..3359): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSLAFDASVKQGDGLIGGEFNVYGPTECCVDAAT
  Nearest Stachelhaus code(s):
    Glu DAKDLGVVDK (85% 8Å match)
  Stachelhaus code match:
    100% (strong)

KZX51_RS16915: Tyr - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (265..659): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SWKNFDSFITHGQSVAAGECNEYGPTENSVVSTI
  Nearest Stachelhaus code(s):
    Trp DPTQVGEVVK (74% 8Å match)
  Stachelhaus code match:
    80% (moderate)

AMP-binding (1778..2177): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNSHFDFSVWEGNQIFGGEINMYGITETTVHVTY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
ToxT | Regulator of MSHA biosynthesis

NZ_JAHXMW010000009.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 82,474 - 103,397 nt. (total: 20,924 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
KZX51_RS21070: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
KZX51_RS21025: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

KZX51_RS21030: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002284.3 |  | 0.40 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000665.5 |  | 0.39 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001594.3 |  | 0.39 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000663.5 |  | 0.38 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000234.5 |  | 0.38 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002284.3 |  | 0.40 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000665.5 |  | 0.39 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001594.3 |  | 0.39 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000663.5 |  | 0.38 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000234.5 |  | 0.38 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
KZX51_RS21030: PT_FPPS_like
Domain 1 (42 - 307): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.37 out of 20.47
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.69 out of 27.78
Confidence: medium
Additional weak hits (6):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 23.25 out of 30.22
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.42 out of 28.14
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.85 out of 30.25
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.84 out of 30.25
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.42 out of 29.38
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.03 out of 29.65
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT | Regulator of MSHA biosynthesis
VqsM | Regulator of quorum-sensing signalling systems