LOCUS       NZ_CP096019            11701 bp    DNA     circular CON 29-JUL-2024
DEFINITION  Halocatena salina strain AD-1 chromosome, complete genome.
ACCESSION   NZ_CP096019
VERSION     NZ_CP096019.1
KEYWORDS    RefSeq.
SOURCE      Halocatena salina
  ORGANISM  Halocatena salina
            Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria;
            Halobacteriales; Haloarculaceae; Halocatena.
REFERENCE   1  (bases 1 to 2527185)
  AUTHORS   Cui,H.-L.
  TITLE     Halocatena sp. nov., isolated from a salt lake
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2527185)
  AUTHORS   Cui,H.-L.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-APR-2022) School of Food and Biological Engineering,
            Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 4
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 477.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023115355.1-RS_2024_07_29
            Annotation Date                   :: 07/29/2024 05:02:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,906
            CDSs (total)                      :: 3,855
            Genes (coding)                    :: 3,749
            CDSs (with protein)               :: 3,749
            Genes (RNA)                       :: 51
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 46
            ncRNAs                            :: 2
            Pseudo Genes (total)              :: 106
            CDSs (without protein)            :: 106
            Pseudo Genes (ambiguous residues) :: 0 of 106
            Pseudo Genes (frameshifted)       :: 56 of 106
            Pseudo Genes (incomplete)         :: 70 of 106
            Pseudo Genes (internal stop)      :: 28 of 106
            Pseudo Genes (multiple problems)  :: 39 of 106
            CRISPR Arrays                     :: 10
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:29:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 705419
            Orig. end                         :: 717120
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP096019.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11701
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11701
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11701
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6701](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6701
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(313..600)
                     /db_xref="GeneID:71927094"
                     /locus_tag="MW046_RS03565"
                     /old_locus_tag="MW046_03565"
     CDS             complement(313..600)
                     /codon_start=1
                     /db_xref="GeneID:71927094"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MW046_RS03565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MW046_03565"
                     /product="hypothetical protein"
                     /protein_id="WP_247994195.1"
                     /transl_table=11
                     /translation="MVYAWEIDSDSVFVTATAEIKEVSQPRQPTQNKEVPRYLSRGTSN
                     SSAVVRDTLGVSSLNGGDRREVHKSAALARSRKTRGLSNDAASASSAHEA"
     gene            complement(657..1904)
                     /db_xref="GeneID:71927095"
                     /gene="glyA"
                     /locus_tag="MW046_RS03570"
                     /old_locus_tag="MW046_03570"
     CDS             complement(657..1904)
                     /EC_number="2.1.2.1"
                     /GO_function="GO:0004372 - glycine hydroxymethyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0070905 - serine binding [Evidence IEA]"
                     /GO_process="GO:0019264 - glycine biosynthetic process from
                     serine [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (83-357). E-value:
                     1.9e-10. Score: 32.4. Matches aSDomain:
                     nrpspksdomains_MW046_RS03570_Aminotran_1_2.1"
                     /codon_start=1
                     /db_xref="GeneID:71927095"
                     /gene="glyA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015320794.1"
                     /locus_tag="MW046_RS03570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MW046_03570"
                     /product="serine hydroxymethyltransferase"
                     /protein_id="WP_247994196.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 7.8e-09, bitscore:
                     32.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYNHVRETDPEVADALVGEVERQRETLAMIASENHVSRAVLEAQ
                     GSTLTNKYAEGYPDARYYGGCECADTVEQLAIDRATELWGAEYVNVQPHSGSQANMGVY
                     LAALDPGDKILSLDLTHGGHLSHGHPKNFAGQVYEVEQYEVDPETGYIDYDALAAHATE
                     FEPDIIVSGYSAYPRQVDWERIQEIATSVDAYHLADIAHITGLVAAGEHPSPVGIADFV
                     TGSTHKTIRAGRGGIIMSSEEHADAIDSAIIPGMQGGPLMHNIAGKAVGFKEALQPEFE
                     EYAAQVVANASALGERLSEHGLSLVSGGTDTHLVLVDLRDSHPDTTGKEVERALEEVGI
                     VLNANTVPGETRSPFVASGIRAGTPALTTRGFDETAIEQVADCIARVVDSPDDSDVKDA
                     VAEDVQTLCAEHPLYE"
     aSDomain        complement(834..1655)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MW046_RS03570_Aminotran_1_2.1"
                     /evalue="1.90E-10"
                     /label="MW046_RS03570_Aminotran_1_2.1"
                     /locus_tag="MW046_RS03570"
                     /protein_end="357"
                     /protein_start="83"
                     /score="32.4"
                     /tool="antismash"
                     /translation="WGAEYVNVQPHSGSQANMGVYLAALDPGDKILSLDLTHGGHLSHG
                     HPKNFAGQVYEVEQYEVDPETGYIDYDALAAHATEFEPDIIVSGYSAYPRQVDWERIQE
                     IATSVDAYHLADIAHITGLVAAGEHPSPVGIADFVTGSTHKTIRAGRGGIIMSSEEHAD
                     AIDSAIIPGMQGGPLMHNIAGKAVGFKEALQPEFEEYAAQVVANASALGERLSEHGLSL
                     VSGGTDTHLVLVDLRDSHPDTTGKEVERALEEVGIVLNANTVPGETRSPFVA"
     gene            2286..3926
                     /db_xref="GeneID:71927096"
                     /locus_tag="MW046_RS03575"
                     /old_locus_tag="MW046_03575"
     CDS             2286..3926
                     /codon_start=1
                     /db_xref="GeneID:71927096"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MW046_RS03575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MW046_03575"
                     /product="hypothetical protein"
                     /protein_id="WP_247994197.1"
                     /transl_table=11
                     /translation="MSRGVAGGSQSVNQPLGPATFTIPKSPEGVATAISVLSAGLSTTG
                     PERSHPGYRMHPPLVEVGTETYVPPRVRRMVPQTEIVIDVPASYDELFVVAPLAYYLGA
                     SVRIGSETPCIRAPGVHRSFGSLPDLKYEVAELLRRVFFLDCLVRDVADEEPPYERAAL
                     GDIGLDPEALRTATPAERLSAYLGVKQGTIMSNLPMWHLSTYVAPSPDMISCLPFLLDD
                     LSLIYPPDSEDMDRNGLLQRALDDFYRGPVASVDIVAPKLQPADLHAWLADDVPADAYT
                     PSVQAYRNRLATSLPETPLDVTVVLNDSMMDGEYEEVAEVYDDTDQTTTMHRSVTVDEL
                     AQIFEAESDFVHFIGHCEVGGLQCHNGELDIESLSSVGARTFFLNACGSYYQGQALVER
                     GSVAGAVTLRKVLNKPAIRVGTTFARLFVTGFGIERAMQLARRRITMSTDYAVVGDGTY
                     ALTDEKVAVARLNKNGRNYTLNYTVSPNRHPGECYYAPFELWPRLTGSQATTDLAPKDV
                     PRVLESLSCPVIHDGELSWAEDLANDFCQ"
     gene            4015..4827
                     /db_xref="GeneID:71927097"
                     /locus_tag="MW046_RS03580"
                     /old_locus_tag="MW046_03580"
     CDS             4015..4827
                     /codon_start=1
                     /db_xref="GeneID:71927097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015763173.1"
                     /locus_tag="MW046_RS03580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MW046_03580"
                     /product="DUF5821 family protein"
                     /protein_id="WP_247994198.1"
                     /transl_table=11
                     /translation="MRSNILESGVEGLLESVLGDATGELYLINPSREILEVSIPAIEQA
                     EDVSVRLLAGERVLKDVLDDFIVGSTAADLIEADRLALRTFDEPTNTLIVSDDAVTAVV
                     SAGGKVAGLVTDDTEFVSATREQYESEWDSAEQFKLRTPPISRVRSTLSEEIGADVAED
                     FDGVLTSLETARGNGEGLDEVTISLLVAAKNEELLYDISKWGEDVGIASKATFSRTKTR
                     LEEMGLVDTEKVPIDVGRPRLRLILGDDRLQSTSSDDLANVAQSLMAS"
     gene            5001..6701
                     /db_xref="GeneID:71927098"
                     /locus_tag="MW046_RS03585"
                     /old_locus_tag="MW046_03585"
     CDS             5001..6701
                     /codon_start=1
                     /db_xref="GeneID:71927098"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014863164.1"
                     /locus_tag="MW046_RS03585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MW046_03585"
                     /product="YcaO-like family protein"
                     /protein_id="WP_247994199.1"
                     /sec_met_domain="YcaO (E-value: 1.9e-58, bitscore: 196.0,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVTVVGSGPAVDAIEAAVSDIDHELSVRSRVETLADDLAVVVGV
                     VGSDVFSIANEEARSNGTPWIAVELGGIGGCSHPSVDVAVSGYGVSTACFDCLRTRVRS
                     GLDDSEADSSDIDPETARFGGALAGRETVKTVSGSSSLFGRVIEVPHARRRIYSVPGCS
                     CTGHREWTLSRAHEERSLQATLERAERAVDDRIGLINEVGEAESFPVPYYLAQLADTTG
                     FSDAQASQQAAGVALGWDEAFMKALGEGLERYCAGVYDSDALYTARAGNLSAPIQPSTF
                     VRPDDPDDTAPIEWVPGEDLHTGETVSLPAARVLFPYEGPGPTITTGLGLGSSGAAALI
                     AGVTEIIERDGALLAWYSTYEPLELSIDDEEYETLVARARAEGLSVTASLLTQDVDIPV
                     IGVAVHRDEEWPAFALGLAADLDPIAAARSACTEALQNWTELRRMGKTGSRNAGGRIGH
                     FASRPPATEEFTNPKQTIPAASIAADGPTGADALDLLLERLSDVGLDAYAARLTTPDVE
                     ALGFEAVRVLVPRAQPLFIGESYFSERARTVPSELGFEPRLQREHHPYP"
     gene            6768..7250
                     /db_xref="GeneID:71927099"
                     /locus_tag="MW046_RS03590"
                     /old_locus_tag="MW046_03590"
     CDS             6768..7250
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:71927099"
                     /inference="COORDINATES: protein motif:HMM:NF025054.4"
                     /locus_tag="MW046_RS03590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MW046_03590"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_247994200.1"
                     /transl_table=11
                     /translation="MSDVSEYVIRAEMDGETARIRDRLAAVGMMHEDIDPDRSRFWVAE
                     KAGSDTDSEIVGTVRLELDRPNALVGSLYVASDHRNNGLGGALIDHVDRAAQSRGVTTL
                     YLFSTDAGTYFEARGYEETPVEETVVAVSDTPQAEYYRNRPELLANEVTFRKSIDG"
     gene            complement(7247..8419)
                     /db_xref="GeneID:71927100"
                     /locus_tag="MW046_RS03595"
                     /old_locus_tag="MW046_03595"
     CDS             complement(7247..8419)
                     /codon_start=1
                     /db_xref="GeneID:71927100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007979289.1"
                     /locus_tag="MW046_RS03595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MW046_03595"
                     /product="DUF63 family protein"
                     /protein_id="WP_247994201.1"
                     /transl_table=11
                     /translation="MDSTERLGSVVSSGRAWIVTAVVATVVVAGGALAFPRQVYDRFIW
                     QYFWGPVYADAYNARCAVLTEEGAKPLTDGCFQAEATGQIVARPGYTVISEIGYAILLL
                     FMLVGVYFLVRRLQLGRNRRIFFALVPFMFLGGALRVVEDATDAVVARTDVGAVIGYPL
                     NTLIISPVIYGVVFVLTLAAILIGLGLVKWDVVQFDQYPVVVAAIGTAAVALTVGYIGY
                     LVATIDTSGTRIGFYPQLPVAVLVLSGLIAGGLYAGLDRFAPWVNEGTGLMGLVVLFAH
                     ALDGVANVIAADWMGALGMGFLGYDPKHPANRIIIEVTRAAVPQSIIDIIGSAWPFLLV
                     KIVAAVLVISLFDDRIFEDSPQYAMLLLVAIVAVGLGPGTRDMLRATFGI"
     gene            complement(8489..9280)
                     /db_xref="GeneID:71927101"
                     /locus_tag="MW046_RS03600"
                     /old_locus_tag="MW046_03600"
     CDS             complement(8489..9280)
                     /codon_start=1
                     /db_xref="GeneID:71927101"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1207: inositol monophosphatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008007601.1"
                     /locus_tag="MW046_RS03600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MW046_03600"
                     /product="inositol monophosphatase"
                     /protein_id="WP_247994202.1"
                     /transl_table=11
                     /translation="MVDAERRVTVARRAANAGANVAMESFRTDIAVETKAHETDPVTQA
                     DRDTQDRVASVLTDAYPGEVIVGEERGTHDTVPDRGAAWVIDPIDGTSNYIRGVRTWAT
                     SVACVVDGECVAAANVFPALDDTYIAGPDGITRNDTPITVSTETEPNAGVVSPTLWGGA
                     SPHDEFITAVGEAVEMFGDLRRSGCTQGSLSRVASGGLDVAISTVDHHPWDTIAGAFMV
                     ERAGGTVTDVDGNRWRYDAPGLVATNGRLHEEALDVVHTVD"
     tRNA            complement(9456..9539)
                     /anticodon=(pos:complement(714921..714923),aa:Leu,seq:caa)
                     /db_xref="GeneID:71927102"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="MW046_RS03605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="MW046_03605"
                     /product="tRNA-Leu"
     gene            complement(9456..9539)
                     /db_xref="GeneID:71927102"
                     /locus_tag="MW046_RS03605"
                     /old_locus_tag="MW046_03605"
     gene            9639..10067
                     /db_xref="GeneID:71927103"
                     /locus_tag="MW046_RS03610"
                     /old_locus_tag="MW046_03610"
     CDS             9639..10067
                     /codon_start=1
                     /db_xref="GeneID:71927103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006672433.1"
                     /locus_tag="MW046_RS03610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MW046_03610"
                     /product="CopG family ribbon-helix-helix protein"
                     /protein_id="WP_247994203.1"
                     /transl_table=11
                     /translation="MTVVSVSMPDALLERLDTFADEHGYTGRSEVVREASRNLLSEFED
                     KRLEDRDLLGVVTVLFNYETSDVEQRMMQLRHEHELLVSSNVHNHVGDRYCMELFVVEG
                     SLEEISTFVGKIRATQDTLSIDYSVIPVDGFEHTLTTE"
     gene            10081..10563
                     /db_xref="GeneID:71927104"
                     /locus_tag="MW046_RS03615"
                     /old_locus_tag="MW046_03615"
     CDS             10081..10563
                     /codon_start=1
                     /db_xref="GeneID:71927104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015763180.1"
                     /locus_tag="MW046_RS03615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MW046_03615"
                     /product="DUF309 domain-containing protein"
                     /protein_id="WP_247994204.1"
                     /transl_table=11
                     /translation="MTDHTRADAPPPDVGNPTGWCPDRHCWEHGTLRQAVVHGVRLYNA
                     GAFHESHDCFEAEWYNYGRGTTESAFAHGMVQVAAGAYKHFDFENDEGMRSLFQTALQY
                     FHGVPRDYYGVDVLDVRTTLTNACNDPSVLHDWRITLDETRPEARPVDFEYASSIT"
     gene            10690..11472
                     /db_xref="GeneID:71927105"
                     /locus_tag="MW046_RS03620"
                     /old_locus_tag="MW046_03620"
     CDS             10690..11472
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:71927105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008847332.1"
                     /locus_tag="MW046_RS03620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MW046_03620"
                     /product="succinylglutamate desuccinylase/aspartoacylase
                     family protein"
                     /protein_id="WP_247994205.1"
                     /transl_table=11
                     /translation="MRVEQLGEGEPNFAVVGSIHGDEPCGAHAIETLLDADLSIDRPVK
                     LIIANERALDRNVRYTETDLNRVFPGDPDADAYETRLAHELLKEIRGCTTLSLHSTQSY
                     SRPFAIVDETGPLAETICPHLSIDVLVETGGFVKNTLVGYVDVVEVECGMQGSQQAAEN
                     AVELVQEFLGAAGVLSGPVETETSTVPIYQLQRQIPKDPESSYAVHVENFERVDAGAPY
                     ATSDETEIRAEEPFYPVLMSSQGYERQLGYAADRSGTL"
ORIGIN
        1 gtaagcgtat cgatgttgtc agtgagcgaa tcgcggatat cgctggcgac ggcgtcacca
       61 tcgagaacgg tggtcattgt gtgaacgagg gcacccaatc gtcataaaac gcacgaacct
      121 gtgtgtattc ccgttacgaa tccgtcgaaa tatacacgtt tgtgagggtg ccatagaaca
      181 cagcacatac gaggacgaat agggtaacca gttggccagt cgctcgatgt gaacgtggcg
      241 tgctccccgg actgaagtcg tgggtctccc gaggttccga tgttacgccc gtcgattcgg
      301 atggttggga gtctacgctt cgtgggccga cgacgcactg gcagcgtcgt tcgaaagacc
      361 tctggtcttt cgtgatctcg caagagctgc gctcttgtgg acctcgcggc ggtcccctcc
      421 gttcagtgat gagacaccga gggtgtctcg aaccaccgca ctactgttac tcgttccccg
      481 cgagaggtag cgaggtacct ccttgttttg cgtcggctgg cgtggttggc ttacttcttt
      541 gatttcggct gtcgccgtga caaacaccga atcactgtca atttcccacg catacaccat
      601 acaaatgaaa tcagtatgca acgtgtgtta ctgttctacg atattccgga ccgtacctat
      661 tcgtacagcg gatgctctgc acagagtgtt tgaacgtctt ccgcgactgc atctttcacg
      721 tccgagtcgt cggggctgtc gacgacgcgg gcgatgcagt cagcgacctg ttcgatcgcc
      781 gtctcatcga agccccgagt ggtgagcgcg ggcgttccag cgcggatgcc gctggccacg
      841 aacggagatc gtgtctcgcc ggggacggtg ttggcattca gcacgatccc cacctcttcg
      901 agcgcgcgct cgacctcctt cccggtcgtg tcagggtgtg aatcccgaag gtcgacgagc
      961 acgagatgag tatcggtccc acccgaaacg aggctcagtc cgtgctcaga cagccgttct
     1021 ccgagggcgc tcgcattagc aacgacttga gcagcgtact cctcgaattc gggttggagt
     1081 gcctccttga agccaacggc cttgcccgcg atgttgtgca tcaacggacc gccctgcatt
     1141 ccgggaatga tggcactgtc gatcgcatcg gcgtgttcct cgctggacat gatgatacca
     1201 ccccgtcccg cgcgaatcgt cttatgcgtc gagccagtaa cgaagtccgc gatgccgacc
     1261 ggagaagggt gttcgccggc ggcgacaagc cccgtgatgt gagcaatatc ggcgaggtga
     1321 taggcatcga cgctcgttgc gatctcctgg atccgttccc agtcgacctg tcgggggtac
     1381 gccgaatagc ccgagacgat tatgtccggt tcgaactcgg tggcgtgggc tgccagcgcg
     1441 tcgtaatcga tataccccgt ttcgggatcg acctcgtact gttcgacctc gtacacctgt
     1501 cccgcgaagt tcttcggatg gccgtggctg aggtggccgc cgtgagtgag atcgagcgag
     1561 aggattttat cgccgggatc aagcgccgcg agatacacgc ccatgttggc ctgagatccg
     1621 ctgtgtggtt ggacgttaac gtactcagcg ccccacagtt ccgttgcacg gtcgatggcg
     1681 agctgctcga ccgtatcggc acactcacag ccgccgtagt accgagcatc ggggtagccc
     1741 tcggcgtatt tgttcgtgag agtgctgcct tgggcttcga gaaccgcacg gctgacgtgg
     1801 ttctcgctgg cgatcatggc gagcgtctcg cgctggcgct cgacctcacc gacgagcgcg
     1861 tcagcgacct ccggatccgt ctcccggacg tggttgtact ccatatccgt cttccagtcc
     1921 gctcacacta taatctaccc gtctagtggt ggccttccgg tgtcgatggc tattttgtgc
     1981 tgggtggata tcatccagtc gttcgcaaac gtgatcgagc acgcacggtt cggcgaccag
     2041 ggagctgctg tctggcgagc ggtggcggtg tggttaatgg gaatacactc accgcaagcg
     2101 ctagcgagcg gttttttagt cctctcagat ggacgacgtc catctgggag cctgcaagag
     2161 cgaagccctt ggaatgtagg ttttttgcgt tcgggtgaac gaagctcacc actcacgcaa
     2221 aaaaagtggg tctagacttc cggagtcggt acctatttgt tgctctaaca ataccagtta
     2281 ctggtatgag tcggggcgtt gccggaggga gccaatcggt caatcagcca ctaggtcctg
     2341 ccacgtttac gatccccaaa tccccagagg gcgtggcgac ggcgatctca gtcctctctg
     2401 ccggtctgtc gacgacgggc ccagagcgtt cgcacccggg ctaccggatg catccaccgc
     2461 tcgttgaggt cgggaccgaa acgtacgtgc caccgcgcgt acgccggatg gtcccacaaa
     2521 cggagatcgt catcgacgtt cctgcgagct atgacgagct gtttgtagtc gcgccgctcg
     2581 cgtactacct cggggcttcc gtccggatcg gctcggaaac accctgcatc cgcgcaccag
     2641 gcgttcaccg ttcgttcgga tcgttacctg atctcaaata cgaagtggct gaactgcttc
     2701 gtcgagtgtt tttcctcgac tgtctcgttc gggacgttgc ggacgaggaa ccaccctacg
     2761 agcgggccgc gctcggcgac attggtctcg acccggaggc gttgcgaacc gcaacgccgg
     2821 ccgaacgact ctcggcatat ctgggggtaa agcagggaac gatcatgtcc aacctcccga
     2881 tgtggcatct ctctacgtac gtcgctccca gccccgatat gatctcgtgt cttccgttct
     2941 tgctcgacga tctcagcctc atctatccgc ccgattccga agacatggat cggaacgggc
     3001 tgttacaacg agcactcgat gatttctacc gaggaccggt cgcatcggtt gatatcgtcg
     3061 cccccaaact ccaaccggca gatctacacg cgtggctcgc cgacgacgtt ccggctgatg
     3121 cgtacacgcc gtcggttcag gcgtaccgca accggctggc gacgtccctt cccgaaacac
     3181 cactcgacgt tacggtcgtc ctcaacgaca gcatgatgga cggggaatac gaggaggtcg
     3241 cagaggtcta tgacgacacc gaccagacga cgaccatgca ccgatcggtg accgtcgacg
     3301 agttagcaca gatcttcgaa gccgaatcgg atttcgtcca cttcattgga cactgtgagg
     3361 tcggcgggct acagtgtcac aacggcgaac tcgacatcga gagtctttcc tcagtcggcg
     3421 cccgtacgtt cttcctcaac gcctgtggct cctactatca ggggcaagcg ctcgtcgagc
     3481 gcggaagcgt cgccggtgcc gtcacgcttc ggaaggtgct caataaaccg gcgatccgcg
     3541 tcggaacgac gttcgctcgg ctgttcgtca ccggattcgg catcgaacgc gcgatgcaac
     3601 tcgcccgcag gcggatcacg atgagcacgg attacgccgt cgtcggcgat gggacgtacg
     3661 cactcaccga cgagaaggtc gccgtagcgc gtttgaacaa aaacggtaga aattacacgc
     3721 tcaactacac cgtctctccg aaccgtcatc ccggagagtg ttactacgcg ccgttcgaac
     3781 tttggccgcg gctcaccggc tcacaagcga cgaccgatct cgcccccaag gacgtcccgc
     3841 gagttctcga atcgctgtcc tgcccggtga tccatgacgg cgagctcagc tgggcggagg
     3901 acctcgctaa tgatttttgt cagtagatga ataatagttt catcgtattc atcgtcttcg
     3961 gtttttgaat aacgcagata ttaaatagta tgggggtata aatattcaac accgatgcgt
     4021 tcgaacatac tagaatcggg tgtcgagggt ctcctggaat ccgttctcgg ggacgccact
     4081 ggcgaactgt atctgatcaa tccatcgcgt gagattctgg aagtgtcgat tccagcgatc
     4141 gagcaagcgg aagacgtttc ggtgcgtctc ctcgctggcg agcgcgtttt gaaggacgtt
     4201 ctcgacgatt tcatcgtcgg gagcactgct gcagatctca tcgaagcgga tcgactcgcg
     4261 ctccgaacgt tcgacgagcc gacgaacacg ctcatcgtct ccgatgatgc cgtgacggcc
     4321 gtcgtttccg ccggtgggaa ggtcgccgga ctcgtgaccg acgatacgga gttcgtatcg
     4381 gccacccgtg aacagtacga aagtgagtgg gactctgcgg agcagttcaa gctccgaacg
     4441 cctccgatct ctcgcgttcg atcgacgctt tccgaagaga tcggtgccga cgtggccgag
     4501 gacttcgacg gcgtcctcac ctcgctcgaa accgcacgcg gcaacggcga aggactagac
     4561 gaagtcacca tcagtctact cgtcgcggcg aaaaacgagg agctgctgta cgacatcagc
     4621 aaatgggggg aagatgtcgg cattgcgagc aaggcgacgt tctcgcgcac caaaacccgt
     4681 ctcgaagaga tgggactcgt cgacaccgag aaagtgccga tcgacgtggg tcgcccacgc
     4741 ctgcgtctca tcctcggtga cgaccggctt cagagcacca gctccgacga tctcgccaac
     4801 gtcgctcaga gcttgatggc ctcctaagag accgaagaca ccggtatcga cgccgacagc
     4861 gtcgtccccg gcccgattcg gatctttcta tggtccgggg ggttcgattc tatcactgga
     4921 gctgtaaggc tacccagacg atcacagacg atcacgagtg aatccgtgtt cctttttcgt
     4981 atcagttcgt tcagtgagtc atgtctgtca ctgtcgtcgg ctccgggcct gcggtagatg
     5041 ccattgaggc ggccgtttcc gacattgatc acgagttatc cgttcgatca agggtcgaga
     5101 cgcttgcgga cgatctcgct gtcgtcgtgg gagtagtcgg atcggacgtg ttctcgatcg
     5161 caaacgagga ggcacgatcg aacggaacac cgtggattgc cgtcgaactc ggcggtatcg
     5221 ggggatgttc ccatccatcg gtcgacgttg ccgtatcggg ctatggggtt tccaccgcgt
     5281 gtttcgattg tcttcgaacg cgcgttcgat ccggactcga cgactcagag gctgattctt
     5341 ccgatattga cccagaaacg gcacgctttg gtggtgctct agccggacgg gagaccgtca
     5401 agacggtgtc cggatcgtcg tcgctgttcg gtcgcgtgat cgaggtgcca cacgcacggc
     5461 gacggatcta ctccgttccg ggctgttcgt gtacgggaca ccgagagtgg acgctgtcga
     5521 gagcgcacga ggaacgatcg ttacaggcga cgctcgaacg agccgagcga gcggtcgacg
     5581 atcggatcgg actgatcaac gaggtgggtg aggccgagtc gttcccggtg ccgtactacc
     5641 tcgcacagct cgccgacact accgggttca gcgacgcgca agcgagccaa caggctgccg
     5701 gtgtcgcact aggatgggac gaggcgttca tgaaagcgct cggtgaggga ctcgaacgct
     5761 actgtgctgg cgtgtacgat tccgatgccc tctacaccgc acgcgcgggg aatctctcgg
     5821 caccgattca gccatcgacg ttcgttcgtc ccgatgatcc ggatgacacc gctccgatag
     5881 agtgggtgcc cggtgaagat ctacacaccg gtgagacggt gtctcttcct gccgcccggg
     5941 tgttgttccc ctatgaagga ccgggaccga ccatcacgac gggacttgga ctcggaagtt
     6001 cgggcgcggc ggcgttgatc gctggggtaa cggagatcat cgaacgggac ggtgcgctgt
     6061 tggcgtggta ctcgacgtac gaacccctgg agctgtcgat tgacgatgag gagtacgaga
     6121 cactcgtcgc ccgagcaaga gcggaagggc tgtcggtgac cgcgtcgctg ttgacccaag
     6181 atgtcgatat cccagtgatc ggcgtggccg tccaccgaga tgaggagtgg ccggcgttcg
     6241 ctctcggtct ggcagccgat ctcgatccga tcgctgccgc tcgatcggcg tgtaccgaag
     6301 cgcttcaaaa ctggacggag cttcgtcgga tgggtaaaac cggttcccga aatgctggcg
     6361 gccggatcgg tcatttcgca tcacgcccac ccgcgacaga ggagttcact aaccccaagc
     6421 agacgattcc agcagcgagc atcgcggcgg acggtcccac gggagcagat gcgctagatc
     6481 tgctcctcga acggctcagt gatgtcggac tcgacgctta tgccgcccga ctgacgacgc
     6541 cggacgtgga ggcgctcggt ttcgaggccg tccgtgtgct cgtgccacga gcacaaccac
     6601 tgttcatcgg tgagtcgtac ttcagcgagc gggcgcggac ggttccctca gagctgggct
     6661 tcgaaccacg actccagcgc gaacaccatc cgtatccgta gccacacgac cccggacgag
     6721 tccgtcgtcc gaacccatat tgtcctgaca gccacaccat cgatcgaatg tctgatgtta
     6781 gcgagtacgt gatcagggcc gaaatggacg gcgaaacagc acggatacgg gatcgtttgg
     6841 cggccgtcgg aatgatgcac gaagacatcg atccggatcg atctcggttt tgggtcgcgg
     6901 agaaggctgg ttcggacact gactcggaaa tcgtcggaac ggtccgcctc gaactcgatc
     6961 ggcccaatgc gctcgtcggt tcgctgtacg tcgcatccga ccatcggaac aacggtctcg
     7021 gtggggcgct catcgaccac gtcgaccgag cggcccagtc gcgtggcgtc acgacactgt
     7081 atctgttcag taccgacgcc ggtacgtact tcgaggcgcg ggggtacgag gaaactccag
     7141 ttgaggagac cgtcgtcgcc gtttcggaca cccctcaagc cgagtactac cgcaaccgac
     7201 cggaactgct cgcaaacgaa gtcacgttcc ggaaatcgat cgacggctag atcccgaacg
     7261 tcgcccggag catatcccgc gtgccgggtc cgagaccgac ggcgacgatg gcgaccaaca
     7321 gtaacatcgc gtactgggga ctgtcctcga agatccgatc gtcgaaaagg gagatgacga
     7381 gtaccgcggc cacgatcttc acgaggagga acggccatgc cgatccgatg atatcgatga
     7441 tcgactgtgg gacggcagct cttgtaacct ctatgattat tcggttggcg ggatgtttgg
     7501 gatcatagcc cagaaatccc attccgagcg cgcccatcca gtcggcggcg atcacgtttg
     7561 cgacgccgtc gagggcgtgc gcgaagagga cgactagccc catcagcccg gtcccctcgt
     7621 tcacccacgg ggcgaaccga tcgaggccgg cgtacagtcc tccagcgatg agtcccgaca
     7681 ggacgagcac ggccaccggg agctgtgggt aaaagccgat cctcgttccc gaggtgtcga
     7741 tcgtggcgac gagatagccg atgtaaccga cggtgagggc gacggcggcc gttccgatcg
     7801 ccgcgacgac cacgggatac tgatcgaact ggacgacgtc ccacttaacc agtccgagtc
     7861 caatcaggat agccgcgagc gtgagaacga agacgacgcc gtagatgacg gggctgatga
     7921 tgagcgtgtt gaggggatag ccgatgaccg ctccaacgtc ggttcgggcg accacggcgt
     7981 cagtggcgtc ctcaacgacc cgcagcgcgc caccgaggaa catgaacggg acgagtgcga
     8041 aaaagatccg gcggttccgg ccgagttgga ggcggcgaac gagaaagtat acgccgacca
     8101 gcatgaacag gagcagtatc gcgtatccga tctcggaaat gaccgtgtat cccggcctag
     8161 cgacgatctg ccccgtcgct tcggcttgga aacagccatc tgtgagcggt ttcgcacctt
     8221 cctcggtcag gaccgcacac cgagcgttgt acgcgtccgc gtaaacggga ccccagaaat
     8281 actgccagat aaaccgatcg tacacctgtc gcgggaaggc aagcgcgcca ccggctacca
     8341 cgacggtggc gaccacggcc gtgacgatcc acgcccgtcc ggaactcacc accgatccga
     8401 gccgttcggt cgagtccata agctaccgca cgttccggtt ccgtccgtgt ttacacttcc
     8461 gatccccctc gtcgaaaacc cgcgacggct agtcgaccgt atgcacgaca tcgagtgctt
     8521 cctcgtggag ccgaccattg gtggcgacca gaccaggtgc gtcgtatcgc caccggttgc
     8581 cgtcgacatc ggtgacagtg cctccagctc gttcgaccat gaacgcccct gcgatcgtat
     8641 cccacgggtg atgatcgacg gtcgagatcg ctacgtcgag tcccccactg gcaacccgcg
     8701 agagcgaacc ttgtgtgcag cccgaacgac ggagatcacc gaacatttcg acagcctccc
     8761 cgacggccgt gatgaactcg tcgtgggggc tggctccccc ccacaacgtc ggtgacacga
     8821 ctcccgcgtt cggctccgtt tccgtactca ccgtgatcgg cgtgtcgttc cgggtgatac
     8881 cgtccggacc agcaatgtaa gtgtcatcga gcgcaggaaa cacgtttgcc gcggccacac
     8941 actcgccgtc cacgacacac gccacactcg tcgcccacgt ccgcacgcca cggatgtagt
     9001 tgctcgttcc gtcgatcgga tcgatcaccc acgccgcacc tcgatcggga acggtgtcgt
     9061 gtgtgcccct ttcctctcca acgatcacct cgcccggata cgcgtccgtg agcaccgatg
     9121 cgacccgatc ctgtgtgtcg cggtcggctt gggtgacggg gtccgtctcg tgggctttcg
     9181 tctcgacagc gatgtcagtg cgaaacgact ccatcgccac gttcgccccc gcgtttgccg
     9241 cccgtcgtgc aaccgtgacc cgtcgctcgg catcgaccat gggatcccct gtcgtcccga
     9301 tcggacaaag ctccgtcggt cagaacatgt ctacgagttc cggttacatc caccgacgga
     9361 gcaaccgctc aggagtgttg tgaatggagc gagggcaaga tcgaaccccg tggaggcgat
     9421 cttgcacgca ctcgcaatga gtaggtgggt gcgagtgcga ggggcaggat ttgaacctgc
     9481 ggacctctac aggagcggat cttgagtccg ccgccgtttc ctaacttggc taccctcgca
     9541 cggatacaca tcgtttctcg gggggttaaa gcgttgcgaa ccgatccccc ctaacggaaa
     9601 tattaacttc taataaccga acggctatag gttaacacat gaccgttgtc agcgtctcca
     9661 tgccggatgc actcctcgaa cggctcgata cgttcgcgga cgaacacggc tacacagggc
     9721 gaagcgaggt cgtccgcgaa gcgtctcgaa atctactcag cgagttcgag gacaagcgcc
     9781 tcgaagaccg cgatctacta ggtgttgtga cagtactttt caattatgaa acatcagatg
     9841 tcgaacaacg gatgatgcag ctgcgtcacg aacacgaact cctcgtttcc tcgaacgtcc
     9901 acaaccacgt cggtgatcgg tactgcatgg aactgttcgt cgtcgaaggc tcgctcgaag
     9961 agatatcgac gtttgtgggg aaaatccgcg cgacacagga cacgctatcg atcgattact
    10021 ccgtcattcc agtggacgga ttcgagcaca cactgaccac tgaatgacgt cactccaccc
    10081 atgactgacc acacccgggc cgacgcacca ccgccagacg tcggaaatcc aaccggctgg
    10141 tgtcccgacc gacactgctg ggaacatggc acgctccggc aagcggtggt tcacggcgtc
    10201 cgtctgtaca acgccggtgc gttccacgaa tcacacgact gtttcgaagc ggaatggtac
    10261 aactacggcc gaggcaccac cgaaagcgcc ttcgctcacg gcatggtcca agtcgcagca
    10321 ggcgcgtaca aacacttcga tttcgaaaac gacgaaggga tgcggagcct ctttcaaact
    10381 gcattgcagt actttcatgg cgttcctcgg gactactacg gcgtcgacgt actcgacgtg
    10441 agaacgacgc tcacgaacgc ctgcaacgat cctagcgtgt tacacgactg gcggatcacg
    10501 ctcgacgaaa cacgtcccga ggcacgtccg gtcgacttcg aatatgcgtc atcgataacg
    10561 taaaaacaac tacgacaaat cctctgacag tttacggcga aaaatgccag agagtgatac
    10621 attgataagg tatgcgtatg acgacaacaa accgcataat tgattacggg gtccgtggta
    10681 ttccaacaca tgcgcgttga acagttgggc gaaggcgaac cgaacttcgc ggttgttgga
    10741 tcgatacatg gtgacgagcc gtgtggcgcg catgcgatcg aaacgctact cgatgctgat
    10801 ctgtccattg accgaccagt aaagctcatc attgcgaacg agcgagcgct cgatcgtaac
    10861 gtgcgttata cagagaccga tctgaaccgc gtctttccgg gcgatcccga tgctgacgcc
    10921 tacgagacac gactggcaca cgaactgttg aaggaaatcc gtggctgtac gacgctgtcg
    10981 ttgcactcga cgcagtcgta cagtcgtccg tttgctatcg tcgatgaaac tgggccactc
    11041 gcggaaacga tctgtccgca tttatcgatc gacgtgctcg ttgaaacggg gggattcgtc
    11101 aagaacacgc tcgtcggcta cgtcgacgtc gtcgaagttg agtgtgggat gcaaggctcc
    11161 cagcaagctg cggagaacgc cgtcgaactc gttcaggaat ttctcggagc ggctggtgtg
    11221 ctttccggac cagtcgagac tgaaacgagt acggttccca tctaccagtt acagcgtcag
    11281 atcccgaagg atcccgaatc atcgtacgcg gttcacgtag aaaatttcga acgagtcgat
    11341 gctggtgcac cctatgccac cagcgacgag acggagatac gcgctgagga gccgttttat
    11401 ccagtcctta tgtcctcaca aggatatgag agacagctcg gatacgcggc cgatcggagc
    11461 ggcaccttgt agctcattcc gattcgttgg aatcgagttc tacgagcgtg agatctcgat
    11521 cgagcataca gaagtcgtgc ggtgggtccc cgatcacctc ccggatagtg tacgacgtgt
    11581 cgaactccgc acccatcggt tcacagtagg ggtgactcgg acagtcggtg tggggacacg
    11641 gcccttcgag ttgagccgtg gatccggcgt acgcgctggt cgacgggacc gtcgcgcgta
    11701 c
//
