Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7
2.1
3.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP096019.1 (Halocatena salina)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | terpene | 176,147 | 196,455 |
Region 1.2 | RiPP-like | 705,420 | 717,120 |
Region 1.3 | terpene-precursor | 925,387 | 946,451 |
Region 1.4 | terpene-precursor | 1,337,150 | 1,358,010 |
Region 1.5 | lanthipeptide-class-ii | 1,441,977 | 1,465,114 |
Region 1.6 | NI-siderophore | 1,564,115 | 1,593,962 |
Region 1.7 | NI-siderophore | 1,649,529 | 1,683,173 | Medium | schizokinen | NRPS:Type IV

NZ_CP096020.1 (Halocatena salina)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | terpene | 342,472 | 363,518 |

NZ_CP096021.1 (Halocatena salina)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 3.1 | lanthipeptide-class-ii | 377,581 | 400,826 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | terpene | 176,147 | 196,455 |
Region 1.2 | RiPP-like | 705,420 | 717,120 |
Region 1.3 | terpene-precursor | 925,387 | 946,451 |
Region 1.4 | terpene-precursor | 1,337,150 | 1,358,010 |
Region 1.5 | lanthipeptide-class-ii | 1,441,977 | 1,465,114 |
Region 1.6 | NI-siderophore | 1,564,115 | 1,593,962 |
Region 1.7 | NI-siderophore | 1,649,529 | 1,683,173 | Medium | schizokinen | NRPS:Type IV
Region 2.1 | terpene | 342,472 | 363,518 |
Region 3.1 | lanthipeptide-class-ii | 377,581 | 400,826 |

No secondary metabolite regions were found in these records:
  NZ_CP096022.1 (Halocatena salina)
  NZ_CP096023.1 (Halocatena salina)

Compact view
NZ_CP096019.1 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 176,147 - 196,455 nt. (total: 20,309 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
MW046_RS00930: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: hydrolase protease
MW046_RS00875: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

MW046_RS00880: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

MW046_RS00885: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000597.4 |  | 0.44 | ribosomal | SWA-2138 | Streptomyces sp. e14
BGC0000504.5 |  | 0.43 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001206.5 |  | 0.42 | other (other) | indolmycin | Streptomyces griseus subsp. griseus
BGC0001485.4 |  | 0.42 | other (other) | chuangxinmycin | Actinoplanes tsinanensis
BGC0001896.4 |  | 0.42 | other (other) | carbazomycin B | Streptomyces luteoverticillatus
BGC0002132.3 |  | 0.41 | ribosomal | group 1 methanobactin | Methylosinus sp. LW4
BGC0002554.2 |  | 0.41 | other (other) | carquinostatin A, carquinostatin B | Streptomyces exfoliatus
BGC0000595.3 |  | 0.40 | ribosomal | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0001903.3 |  | 0.38 | other (other) | neocarazostatin A | Streptomyces sp. MA37
BGC0000925.5 |  | 0.37 | other (other) | quinolobactin | Pseudomonas fluorescens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000597.4 |  | 0.44 | ribosomal | SWA-2138 | Streptomyces sp. e14
BGC0000504.5 |  | 0.43 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001206.5 |  | 0.42 | other (other) | indolmycin | Streptomyces griseus subsp. griseus
BGC0001485.4 |  | 0.42 | other (other) | chuangxinmycin | Actinoplanes tsinanensis
BGC0001896.4 |  | 0.42 | other (other) | carbazomycin B | Streptomyces luteoverticillatus
BGC0002132.3 |  | 0.41 | ribosomal | group 1 methanobactin | Methylosinus sp. LW4
BGC0002554.2 |  | 0.41 | other (other) | carquinostatin A, carquinostatin B | Streptomyces exfoliatus
BGC0000595.3 |  | 0.40 | ribosomal | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0001903.3 |  | 0.38 | other (other) | neocarazostatin A | Streptomyces sp. MA37
BGC0000925.5 |  | 0.37 | other (other) | quinolobactin | Pseudomonas fluorescens

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
tetraterpene | C40 carotenoid |  | C40 | unknown | unknown

Genes with terpene domains:
MW046_RS00895: Lycopene_cycl
Domain 1 (11 - 90): Lycopene cyclase

Reactions:
  C40_carotenoid → C40_carotenoid

Terpene
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
NZ_CP096019.1 - Region 2 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 705,420 - 717,120 nt. (total: 11,701 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: phosphatase
MW046_RS03600: inositol monophosphatase

smcogs
  SMCOG1207: inositol monophosphatase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000878.5 |  | 0.35 | other (other) | puromycin | Streptomyces alboniger
BGC0000249.5 |  | 0.29 | PKS | nogalamycin | Streptomyces nogalater
BGC0000716.5 |  | 0.26 | saccharide | spectinomycin | Streptomyces netropsis
BGC0000715.5 |  | 0.25 | saccharide | actinospectacin | Streptomyces spectabilis
BGC0000243.4 |  | 0.23 | PKS | nonactin, monactin, dinactin, trinactin, tetranactin | Streptomyces griseus subsp. griseus
BGC0002652.2 |  | 0.23 | other (other), saccharide | cytosaminomycin F, cytosaminomycin G, streptcytosine P, plicacetin, 40551-F, 12F-plicacetin, streptcytosine D, streptcytosine E | Streptomyces sp. SHP22-7
BGC0002288.2 |  | 0.21 | NRPS | ashimide A, ashimide B | Streptomyces sp. NA03103
BGC0002012.4 |  | 0.21 | PKS | julichrome Q3-3, julichrome Q3-5 | Streptomyces afghaniensis 772
BGC0001379.5 |  | 0.21 | NRPS | BD-12 | Streptomyces luteocolor
BGC0000873.3 |  | 0.21 | other (other) | A-201A | Saccharothrix mutabilis subsp. capreolus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000878.5 |  | 0.35 | other (other) | puromycin | Streptomyces alboniger
BGC0000249.5 |  | 0.29 | PKS | nogalamycin | Streptomyces nogalater
BGC0000716.5 |  | 0.26 | saccharide | spectinomycin | Streptomyces netropsis
BGC0000715.5 |  | 0.25 | saccharide | actinospectacin | Streptomyces spectabilis
BGC0000243.4 |  | 0.23 | PKS | nonactin, monactin, dinactin, trinactin, tetranactin | Streptomyces griseus subsp. griseus
BGC0002652.2 |  | 0.23 | other (other), saccharide | cytosaminomycin F, cytosaminomycin G, streptcytosine P, plicacetin, 40551-F, 12F-plicacetin, streptcytosine D, streptcytosine E | Streptomyces sp. SHP22-7
BGC0002288.2 |  | 0.21 | NRPS | ashimide A, ashimide B | Streptomyces sp. NA03103
BGC0002012.4 |  | 0.21 | PKS | julichrome Q3-3, julichrome Q3-5 | Streptomyces afghaniensis 772
BGC0001379.5 |  | 0.21 | NRPS | BD-12 | Streptomyces luteocolor
BGC0000873.3 |  | 0.21 | other (other) | A-201A | Saccharothrix mutabilis subsp. capreolus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

NZ_CP096019.1 - Region 3 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 925,387 - 946,451 nt. (total: 21,065 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: synthase synthetase
MW046_RS04730: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

MW046_RS04750: polyprenol-monophosphomannose synthase ppm1

smcogs
  SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002736.2 |  | 0.50 | terpene | preaspterpenacid I | Aspergillus terreus NIH2624
BGC0002162.3 |  | 0.49 | terpene | sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8 | Aspergillus fischeri NRRL 181
BGC0002610.3 |  | 0.49 | terpene | stellatic acid | Aspergillus stellatus
BGC0001528.4 |  | 0.43 | terpene | betaestacin I, betaestacin II | Phoma betae
BGC0001659.3 |  | 0.42 | terpene | mangicol A | Fusarium equiseti
BGC0002219.2 |  | 0.39 | terpene | (-)-(R)-nephthenol | Stereum hirsutum FP-91666 SS1
BGC0002218.2 |  | 0.38 | terpene | (-)-Cyatha-3,12-diene | Dentipellis sp. KUC8613
BGC0000646.5 |  | 0.38 | terpene | β-carotein | uncultured bacterium
BGC0001910.4 |  | 0.37 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0001529.5 |  | 0.36 | other (other) | benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K | Streptomyces sp. RI18

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002736.2 |  | 0.50 | terpene | preaspterpenacid I | Aspergillus terreus NIH2624
BGC0002162.3 |  | 0.49 | terpene | sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8 | Aspergillus fischeri NRRL 181
BGC0002610.3 |  | 0.49 | terpene | stellatic acid | Aspergillus stellatus
BGC0001528.4 |  | 0.43 | terpene | betaestacin I, betaestacin II | Phoma betae
BGC0001659.3 |  | 0.42 | terpene | mangicol A | Fusarium equiseti
BGC0002219.2 |  | 0.39 | terpene | (-)-(R)-nephthenol | Stereum hirsutum FP-91666 SS1
BGC0002218.2 |  | 0.38 | terpene | (-)-Cyatha-3,12-diene | Dentipellis sp. KUC8613
BGC0000646.5 |  | 0.38 | terpene | β-carotein | uncultured bacterium
BGC0001910.4 |  | 0.37 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0001529.5 |  | 0.36 | other (other) | benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K | Streptomyces sp. RI18

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
MW046_RS04730: PT_FPPS_like
Domain 1 (50 - 348): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Terpene
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

NZ_CP096019.1 - Region 4 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,337,150 - 1,358,010 nt. (total: 20,861 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
MW046_RS06925: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Ligases: synthetase
MW046_RS06905: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002162.3 |  | 0.50 | terpene | sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8 | Aspergillus fischeri NRRL 181
BGC0001226.4 |  | 0.43 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0001528.4 |  | 0.40 | terpene | betaestacin I, betaestacin II | Phoma betae
BGC0000521.3 |  | 0.40 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000676.5 |  | 0.39 | terpene | aphidicolin, aphidicolan-16β-ol, 3-deoxyaphidicolin, 17-deoxyaphidicolin | Phoma betae
BGC0001743.3 |  | 0.39 | ribosomal | plantaricyclin | Lactobacillus plantarum
BGC0000643.3 |  | 0.39 | terpene | carotenoid | Brevundimonas vesicularis
BGC0000523.3 |  | 0.38 | ribosomal | lactocin S | Lactobacillus sakei
BGC0001779.5 |  | 0.38 | ribosomal | siamycin | Streptomyces nodosus
BGC0002110.3 |  | 0.38 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002162.3 |  | 0.50 | terpene | sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8 | Aspergillus fischeri NRRL 181
BGC0001226.4 |  | 0.43 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0001528.4 |  | 0.40 | terpene | betaestacin I, betaestacin II | Phoma betae
BGC0000521.3 |  | 0.40 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000676.5 |  | 0.39 | terpene | aphidicolin, aphidicolan-16β-ol, 3-deoxyaphidicolin, 17-deoxyaphidicolin | Phoma betae
BGC0001743.3 |  | 0.39 | ribosomal | plantaricyclin | Lactobacillus plantarum
BGC0000643.3 |  | 0.39 | terpene | carotenoid | Brevundimonas vesicularis
BGC0000523.3 |  | 0.38 | ribosomal | lactocin S | Lactobacillus sakei
BGC0001779.5 |  | 0.38 | ribosomal | siamycin | Streptomyces nodosus
BGC0002110.3 |  | 0.38 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
MW046_RS06905: PT_FPPS_like
Domain 1 (29 - 276): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Terpene
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

NZ_CP096019.1 - Region 5 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,441,977 - 1,465,114 nt. (total: 23,138 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
MW046_RS07395: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

Lyases: cyclase dehydratase
MW046_RS07415: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

MW046_RS07445: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002703.2 |  | 0.47 | ribosomal | archalan α | Halorussus salinus
BGC0002704.2 |  | 0.47 | ribosomal | archalan β | Halorussus salinus
BGC0000554.4 |  | 0.42 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000528.5 |  | 0.42 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002407.3 |  | 0.42 | other (other), saccharide | angustmycin A, angustmycin C | Streptomyces angustmyceticus
BGC0000503.5 |  | 0.40 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0001210.5 |  | 0.39 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002346.3 |  | 0.38 | ribosomal | kyamicin | Saccharopolyspora sp.
BGC0002621.2 |  | 0.38 | other (other) | angustmycin A, angustmycin B, angustmycin C, aristeromycin, arabinofuranosyladenine | Streptomyces angustmyceticus
BGC0000527.5 |  | 0.36 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002703.2 |  | 0.47 | ribosomal | archalan α | Halorussus salinus
BGC0002704.2 |  | 0.47 | ribosomal | archalan β | Halorussus salinus
BGC0000554.4 |  | 0.42 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000528.5 |  | 0.42 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002407.3 |  | 0.42 | other (other), saccharide | angustmycin A, angustmycin C | Streptomyces angustmyceticus
BGC0000503.5 |  | 0.40 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0001210.5 |  | 0.39 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002346.3 |  | 0.38 | ribosomal | kyamicin | Saccharopolyspora sp.
BGC0002621.2 |  | 0.38 | other (other) | angustmycin A, angustmycin B, angustmycin C, aristeromycin, arabinofuranosyladenine | Streptomyces angustmyceticus
BGC0000527.5 |  | 0.36 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for MW046_RS07445

MW046_RS07405
Leader:
MVEEPMLKGM
Core:
P R C L N C G F E A P H D G G E W N S A Q V P P L G D L M R C P E C G S T N I L G R W
Core with dehydrations:
P R Cys L N Cys G F E A P H D G G E W N Dha A Q V P P L G D L M R Cys P E Cys G Dha Dhb N I L G R W

#### antiSMASH-DB 4.0 matches for MW046_RS07405

100.0%
NZ_CP096019.1:
Lanthipeptides: MW046_RS07405_lanthipeptide
1
P R C L N C G F E A P H D G G E W N S A Q V P P L G D L M R C P E C G S T N I L G R W
43
P R C L N C G F E A P H D G G E W N S A Q V P P L G D L M R C P E C G S T N I L G R W
1
P R C L N C G F E A P H D G G E W N S A Q V P P L G D L M R C P E C G S T N I L G R W
43
18.6%
NZ_KB217478.1:
Lanthipeptides: allorf_3684331_3684489_lanthipeptide
18
N S A Q V P P L G D L M R C P
32
+ A Q V P L L+ C P
13
H R A Q V P T L Y T L I N C P
27
16.3%
NZ_FOET01000004.1:
Lanthipeptides: allorf_078361_078546_lanthipeptide
32
P E C G S T N I L G R W
43
P C G + L G R W
17
P P C G G S E A L G R W
28
with 1 more sequence matches
14.0%
NZ_SNZH01000011.1:
Lanthipeptides: allorf_232150_232323_lanthipeptide
14
G G E W N S A Q V P P
24
G G+W + +V P P
27
G G D W A T M R V P P
37
MW046_RS07480
Leader:
MTKKENRVVQGRMVTPESLAERIEDDSVMDA
Core:
E S I S D T D R E C P D C G G P V V S V G Y M P S V M E F V T G Y K C Q D C D W K A T D R E
Core with dehydrations:
E Dha I Dha D Dhb D R E Cys P D Cys G G P V V Dha V G Y M P Dha V M E F V Dhb G Y K Cys Q D Cys D W K A Dhb D R E

#### antiSMASH-DB 4.0 matches for MW046_RS07480

100.0%
NZ_CP096019.1:
Lanthipeptides: MW046_RS07480_lanthipeptide
1
E S I S D T D R E C P D C G G P V V S V G Y M P S V M E F V T G Y K C Q D C D W K A T D R E
46
E S I S D T D R E C P D C G G P V V S V G Y M P S V M E F V T G Y K C Q D C D W K A T D R E
1
E S I S D T D R E C P D C G G P V V S V G Y M P S V M E F V T G Y K C Q D C D W K A T D R E
46
78.3%
NZ_CP096658.1 and 1 other:
NZ_ML974127.1 Lanthipeptides: EPL00_RS07765_lanthipeptide
Lanthipeptides: M0R88_RS16185_lanthipeptide
1
E S I S D T D R E C P D C G G P V V S V G Y M P S V M E F V T G Y K C Q D C D W K A T D R E
46
E+I S+T D R E C P D C G G V+ V G Y M P S V E F V T G+K C Q D C D W T D R+
1
E A I S E T D R E C P D C G G D V L E V G Y M P S V T E F V T G W K C Q D C D W A D T D R D
46
78.3%
NZ_CP119804.1:
Lanthipeptides: P2T57_RS03940_lanthipeptide
1
E S I S D T D R E C P D C G G P V V S V G Y M P S V M E F V T G Y K C Q D C D W K A T D R E
46
E S I D T D R E C P D C G V+ V G Y M P S V E F V T G+K C Q+C D W T D R E
1
E S I E D T D R E C P D C G E D V L E V G Y M P S V T E F V T G W K C Q E C D W S D T D R E
46
with 2 more sequence matches
21.7%
NZ_BKZV01000001.1:
Lanthipeptides: allorf_0684841_0685035_lanthipeptide
4
S D T D R E C P D C G G-P V V S V G Y
22
S D T C P D G P G Y
2
S D T R G S C P D S G K L P A H Q Q G Y
21
17.4%
NZ_ML974127.1:
Lanthipeptides: EPL00_RS07380_lanthipeptide
5
D T D R E C P D C G G P V V S V
20
D +C P D C G G + V
15
D L P P K C P D C G G A L T F V
30

#### MIBiG 4.0 matches for MW046_RS07480

8.7%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
24
P S V M E F V
30
P+V +F V
6
P T V A Q F V
12
allorf_1444717_1444914
Leader:
MIGSRGSTMSVINRISDAFFDKEHDQGPYA
Core:
C Q S C D R R F S L Q Y Q V C P E C G G Y A I E R V D W S E H I Q N K
Core with dehydrations:
Cys Q Dha Cys D R R F Dha L Q Y Q V Cys P E Cys G G Y A I E R V D W Dha E H I Q N K

#### antiSMASH-DB 4.0 matches for allorf_1444717_1444914

100.0%
NZ_CP096019.1:
Lanthipeptides: allorf_1444717_1444914_lanthipeptide
1
C Q S C D R R F S L Q Y Q V C P E C G G Y A I E R V D W S E H I Q N K
35
C Q S C D R R F S L Q Y Q V C P E C G G Y A I E R V D W S E H I Q N K
1
C Q S C D R R F S L Q Y Q V C P E C G G Y A I E R V D W S E H I Q N K
35
13.0%
NZ_CP096658.1 and 1 other:
NZ_ML974127.1 Lanthipeptides: EPL00_RS07765_lanthipeptide
Lanthipeptides: M0R88_RS16185_lanthipeptide
15
C P E C G G Y A I E
24
C P+C G G +E
10
C P D C G G D V L E
19
10.9%
NZ_CP096019.1:
Lanthipeptides: MW046_RS07480_lanthipeptide
15
C P E C G G Y A I
23
C P+C G G +
10
C P D C G G P V V
18
allorf_1451265_1451483
Leader:
MRVIGFSSMGSRITLSDVRRGSLWFSLSATSNTSPFSSSNNVERLRIVCG
Core:
L C L P R R F R S S Y A E E V S C L R T P G
Core with dehydrations:
L Cys L P R R F R Dha Dha Y A E E V Dha Cys L R Dhb P G

#### antiSMASH-DB 4.0 matches for allorf_1451265_1451483

100.0%
NZ_CP096019.1:
Lanthipeptides: allorf_1451265_1451483_lanthipeptide
1
L C L P R R F R S S Y A E E V S C L R T P G
22
L C L P R R F R S S Y A E E V S C L R T P G
1
L C L P R R F R S S Y A E E V S C L R T P G
22
22.2%
NZ_CP076103.1:
Lanthipeptides: allorf_0713923_0714084_lanthipeptide
6
R F R S S Y A E E V S C L R T P G
22
R R S A C+R P G
3
R Q R S P D A G R E P C I R A P G
19
21.1%
NZ_FMXV01000009.1:
Lanthipeptides: allorf_148352_148558_lanthipeptide
7
F R S S Y A E E V S C L R T P G
22
F R+ E +C L R T G
4
F R A G K T T E S A C L R T V G
19
with 1 more sequence matches
19.5%
NZ_CP026498.1:
Lanthipeptides: C2142_RS40575_lanthipeptide
9
S S Y A E E V S C L R T P
21
S S A +S C R T P
24
S S I A R V M S C Y R T P
36

#### MIBiG 4.0 matches for allorf_1451265_1451483

18.2%
BGC0000580.3 (EGD17354.1):
Lasso peptide: xanthomonin II or xanthomonin I
12
A E E V S C L R T P G
22
E E+ P G
6
G E E I G G F N V P G
16
allorf_1459608_1459736
Leader:
MNWNQTVLLAA
Core:
L C G L R L V G F K P S S D L S T P T H V R V Q Q N G D G G I
Core with dehydrations:
L Cys G L R L V G F K P Dha Dha D L Dha Dhb P Dhb H V R V Q Q N G D G G I

#### antiSMASH-DB 4.0 matches for allorf_1459608_1459736

100.0%
NZ_CP096019.1:
Lanthipeptides: allorf_1459608_1459736_lanthipeptide
1
L C G L R L V G F K P S S D L S T P T H V R V Q Q N G D G G I
31
L C G L R L V G F K P S S D L S T P T H V R V Q Q N G D G G I
1
L C G L R L V G F K P S S D L S T P T H V R V Q Q N G D G G I
31
22.6%
NZ_JSAK01000013.1:
Lanthipeptides: allorf_132009_132119_lanthipeptide
9
F K P S S D L S T P T H V R V Q Q N G D G G I
31
++P+ + T H R Q G G+
2
Y R P A L S A A A R T H K R P D Q C G G Y G L
24
18.4%
NZ_CP013655.1:
Lanthipeptides: allorf_0893480_0893704_lanthipeptide
5
R L V G F K P S S D L S T P T H
20
R L K P S L S T H
7
R L T L M K P S R Y L S T S I H
22
with 1 more sequence matches
17.0%
NZ_CP051010.1:
Lanthipeptides: allorf_00747232_00747402_lanthipeptide
1
L C G L R L V G F K P S S D L S T P
18
+ G R G P S S T P
2
M M G A R K A G V N P S R Q P S T P
19
allorf_1464799_1464885
Leader:
MWMSAVISIGTGRLEEKRRIEKA
Core:
C T W E T
Core with dehydrations:
Cys Dhb W E Dhb

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

MW046_RS07405 - Class II
  Cleavage pHMM score: -5.00
  RODEO score: 0
  Monoisotopic mass: 4628.1 Da
  Molecular weight: 4631.2 Da
  Number of bridges: 3
MW046_RS07480 - Class II
  Cleavage pHMM score: -4.80
  RODEO score: 0
  Monoisotopic mass: 4978.2 Da
  Molecular weight: 4981.5 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4999.5 Da N = 1
    5017.5 Da N = 2
    5035.5 Da N = 3
allorf_1444717_1444914 - Class II
  Cleavage pHMM score: -4.20
  RODEO score: 0
  Monoisotopic mass: 4092.9 Da
  Molecular weight: 4095.5 Da
  Number of bridges: 3
allorf_1451265_1451483 - Class II
  Cleavage pHMM score: -6.80
  RODEO score: 0
  Monoisotopic mass: 2467.3 Da
  Molecular weight: 2468.8 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2486.9 Da N = 1
    2504.9 Da N = 2
allorf_1459608_1459736 - Class II
  Cleavage pHMM score: -5.30
  RODEO score: 0
  Monoisotopic mass: 3160.7 Da
  Molecular weight: 3162.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3180.6 Da N = 1
    3198.6 Da N = 2
    3216.6 Da N = 3
    3234.6 Da N = 4
allorf_1464799_1464885 - Class II
  Cleavage pHMM score: -7.20
  RODEO score: 0
  Monoisotopic mass: 602.2 Da
  Molecular weight: 602.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    620.7 Da N = 1

NZ_CP096019.1 - Region 6 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,564,115 - 1,593,962 nt. (total: 29,848 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
MW046_RS08085: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: halogenase methyltransferase
MW046_RS08020: methyltransferase

smcogs
  SMCOG1089: methyltransferase

MW046_RS08080: halogenase

smcogs
  SMCOG1119: halogenase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001478.5 |  | 0.53 | other (other) | desferrioxamine E | Streptomyces sp. ID38640
BGC0000941.3 |  | 0.52 | other (other) | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001572.3 |  | 0.50 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0002305.2 |  | 0.49 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0002464.3 |  | 0.45 | other (other) | alcaligin | Bordetella pertussis Tohama I
BGC0002620.2 |  | 0.44 | other (other) | fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4 | Fulvivirga marina
BGC0001531.5 |  | 0.44 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0000673.3 |  | 0.44 | terpene | pimara-8(14),15-diene | Aspergillus nidulans FGSC A4
BGC0002692.2 |  | 0.44 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0002362.3 |  | 0.42 | PKS | loseolamycin A1, loseolamycin A2 | Micromonospora endolithica

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001478.5 |  | 0.53 | other (other) | desferrioxamine E | Streptomyces sp. ID38640
BGC0000941.3 |  | 0.52 | other (other) | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001572.3 |  | 0.50 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0002305.2 |  | 0.49 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0002464.3 |  | 0.45 | other (other) | alcaligin | Bordetella pertussis Tohama I
BGC0002620.2 |  | 0.44 | other (other) | fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4 | Fulvivirga marina
BGC0001531.5 |  | 0.44 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0000673.3 |  | 0.44 | terpene | pimara-8(14),15-diene | Aspergillus nidulans FGSC A4
BGC0002692.2 |  | 0.44 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0002362.3 |  | 0.42 | PKS | loseolamycin A1, loseolamycin A2 | Micromonospora endolithica

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

NZ_CP096019.1 - Region 7 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,649,529 - 1,683,173 nt. (total: 33,645 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
MW046_RS08465: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

MW046_RS08510: lysine/ornithine N-monooxygenase

smcogs
  SMCOG1080: lysine/ornithine N-monooxygenase

Transferases: aminotransferase methyltransferase transferase
MW046_RS08480: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

MW046_RS08490: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

MW046_RS08520: methyltransferase

smcogs
  SMCOG1248: methyltransferase

Lyases: decarboxylase
MW046_RS08495: Decarboxylase, pyridoxal-dependent

smcogs
  SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: synthase
MW046_RS08470: carbamoyl phosphate synthase small subunit

smcogs
  SMCOG1249: carbamoyl phosphate synthase small subunit

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002633.2 |  | 0.65 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376
BGC0002683.2 |  | 0.62 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0001478.5 |  | 0.61 | other (other) | desferrioxamine E | Streptomyces sp. ID38640
BGC0002692.2 |  | 0.60 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0000941.3 |  | 0.60 | other (other) | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002469.2 |  | 0.59 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0001572.3 |  | 0.59 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0001531.5 |  | 0.58 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0001499.5 |  | 0.57 | other (other) | aerobactin | Pantoea ananatis
BGC0002305.2 |  | 0.57 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002633.2 |  | 0.65 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376
BGC0002683.2 |  | 0.62 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0001478.5 |  | 0.61 | other (other) | desferrioxamine E | Streptomyces sp. ID38640
BGC0002692.2 |  | 0.60 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0000941.3 |  | 0.60 | other (other) | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002469.2 |  | 0.59 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0001572.3 |  | 0.59 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0001531.5 |  | 0.58 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0001499.5 |  | 0.57 | other (other) | aerobactin | Pantoea ananatis
BGC0002305.2 |  | 0.57 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

NZ_CP096020.1 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 342,472 - 363,518 nt. (total: 21,047 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
MW046_RS14460: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

Hydrolases: hydrolase
MW046_RS14490: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000650.3 |  | 0.49 | terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000645.3 |  | 0.47 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000644.3 |  | 0.46 | terpene | carotenoid | Dietzia sp. CQ4
BGC0000637.3 |  | 0.45 | terpene | carotenoid | Corynebacterium glutamicum
BGC0000648.3 |  | 0.44 | terpene | carotenoid | Myxococcus xanthus
BGC0000664.5 |  | 0.43 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000633.3 |  | 0.42 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.42 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0001456.3 |  | 0.41 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000752.3 |  | 0.40 | saccharide | capsular polysaccharide | Actinobacillus pleuropneumoniae serovar 6 str. Femo

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000650.3 |  | 0.49 | terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000645.3 |  | 0.47 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000644.3 |  | 0.46 | terpene | carotenoid | Dietzia sp. CQ4
BGC0000637.3 |  | 0.45 | terpene | carotenoid | Corynebacterium glutamicum
BGC0000648.3 |  | 0.44 | terpene | carotenoid | Myxococcus xanthus
BGC0000664.5 |  | 0.43 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000633.3 |  | 0.42 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.42 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0001456.3 |  | 0.41 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000752.3 |  | 0.40 | saccharide | capsular polysaccharide | Actinobacillus pleuropneumoniae serovar 6 str. Femo

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene |  | squalene | C30 | acyclic | none
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none
triterpene |  | PSPP | C30 | acyclic | PP
tetraterpene | C40 carotenoid | phytoene | C40 | acyclic | none
triterpene |  | hydroxysqualene | C30 | acyclic | OH

Genes with terpene domains:
MW046_RS14475: PT_phytoene_like
Domain 1 (9 - 287): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → squalene
  FPP → diapophytoene
  FPP → PSPP
  GGPP → phytoene
  PSPP → hydroxysqualene

Terpene
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
PP | Diphosphate
PSPP | Presqualene diphosphate

NZ_CP096021.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 377,581 - 400,826 nt. (total: 23,246 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
MW046_RS16980: dehydrogenase

smcogs
  SMCOG1072: dehydrogenase

Transferases: sulfhydrylase
MW046_RS17030: O-succinylhomoserine sulfhydrylase

smcogs
  SMCOG1168: O-succinylhomoserine sulfhydrylase

Lyases: cyclase
MW046_RS17010: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002703.2 |  | 0.50 | ribosomal | archalan α | Halorussus salinus
BGC0000525.5 |  | 0.50 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000554.4 |  | 0.47 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001579.4 |  | 0.47 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0002704.2 |  | 0.47 | ribosomal | archalan β | Halorussus salinus
BGC0001226.4 |  | 0.44 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0000563.4 |  | 0.44 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001660.3 |  | 0.43 | ribosomal | mathermycin | Marinactinospora thermotolerans
BGC0001210.5 |  | 0.43 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000503.5 |  | 0.43 | ribosomal | cinnamycin | Streptomyces cinnamoneus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002703.2 |  | 0.50 | ribosomal | archalan α | Halorussus salinus
BGC0000525.5 |  | 0.50 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000554.4 |  | 0.47 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001579.4 |  | 0.47 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0002704.2 |  | 0.47 | ribosomal | archalan β | Halorussus salinus
BGC0001226.4 |  | 0.44 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0000563.4 |  | 0.44 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001660.3 |  | 0.43 | ribosomal | mathermycin | Marinactinospora thermotolerans
BGC0001210.5 |  | 0.43 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000503.5 |  | 0.43 | ribosomal | cinnamycin | Streptomyces cinnamoneus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for MW046_RS17010

allorf_381222_381323
Leader:
MSTRSRKASSPLLRFLQYSLNGA
Core:
P V W L C S N M H H
Core with dehydrations:
P V W L Cys Dha N M H H

#### antiSMASH-DB 4.0 matches for allorf_381222_381323

100.0%
NZ_CP096021.1:
Lanthipeptides: allorf_381222_381323_lanthipeptide
1
P V W L C S N M H H
10
P V W L C S N M H H
1
P V W L C S N M H H
10
41.7%
NZ_CP035758.1:
Lanthipeptides: allorf_08105248_08105364_lanthipeptide
3
W L C S N M H
9
W L C S N +
6
W L C S N F Y
12
31.2%
NZ_CP076103.1:
Lanthipeptides: allorf_4170363_4170485_lanthipeptide
2
V W L C S N M H H
10
W L C S+ H
1
A W L C S S T G H
9
with 2 more sequence matches
25.0%
NZ_BFCH01000018.1:
Lanthipeptides: allorf_0588167_0588340_lanthipeptide
1
P V W L C S N M H
9
P+W+C S H
5
P L W I C S F P H
13
19.2%
NZ_FPJC01000031.1 and 1 other:
NZ_SMCJ01000020.1 Lanthipeptides: allorf_004032_004139_lanthipeptide
Lanthipeptides: allorf_04653_04760_lanthipeptide
1
P V W L C S N M H H
10
P W L S +H+
5
P G W L A S G L H Y
14
allorf_381296_381424
Leader:
MVMLEYA
Core:
P L N R E V S P T I S F S S V R G I R R N L R D R Y R G L L C P C K A
Core with dehydrations:
P L N R E V Dha P Dhb I Dha F Dha Dha V R G I R R N L R D R Y R G L L Cys P Cys K A

#### antiSMASH-DB 4.0 matches for allorf_381296_381424

100.0%
NZ_CP096021.1:
Lanthipeptides: allorf_381296_381424_lanthipeptide
1
P L N R E V S P T I S F S S V R G I R R N L R D R Y R G L L C P C K A
35
P L N R E V S P T I S F S S V R G I R R N L R D R Y R G L L C P C K A
1
P L N R E V S P T I S F S S V R G I R R N L R D R Y R G L L C P C K A
35
17.1%
NZ_LMUE01000002.1:
Lanthipeptides: allorf_0093464_0093586_lanthipeptide
19
R R N L R D R Y R G L L C
31
N L D R+ L C
8
H E N L H D R H E M L H C
20
allorf_381863_381931
Leader:
MLGLKQNSHGS
Core:
G D M L E R P S T A C
Core with dehydrations:
G D M L E R P Dha Dhb A Cys

#### antiSMASH-DB 4.0 matches for allorf_381863_381931

100.0%
NZ_CP096021.1:
Lanthipeptides: allorf_381863_381931_lanthipeptide
1
G D M L E R P S T A C
11
G D M L E R P S T A C
1
G D M L E R P S T A C
11
40.0%
NZ_JOJC01000008.1:
Lanthipeptides: allorf_044604_044705_lanthipeptide
3
M L E R P S T A C
11
M R P S T C
7
M G N R P S T D C
15
20.0%
NZ_CP039292.1 and 1 other:
NZ_CP039292.1 Lanthipeptides: allorf_0075864_0076013_lanthipeptide
Lanthipeptides: allorf_0075864_0076013_lanthipeptide
4
L E R P S T A C
11
L R P S A C
15
L N R P S R A C
22
allorf_383135_383269
Leader:
MREHLAVSGG
Core:
R N A V Y F K Y Y H P I R I C S W I T S P R P H D R R S V A S A T H
Core with dehydrations:
R N A V Y F K Y Y H P I R I Cys Dha W I Dhb Dha P R P H D R R Dha V A Dha A Dhb H

#### antiSMASH-DB 4.0 matches for allorf_383135_383269

100.0%
NZ_CP096021.1:
Lanthipeptides: allorf_383135_383269_lanthipeptide
1
R N A V Y F K Y Y H P I R I C S W I T S P R P H D R R S V A S A T H
34
R N A V Y F K Y Y H P I R I C S W I T S P R P H D R R S V A S A T H
1
R N A V Y F K Y Y H P I R I C S W I T S P R P H D R R S V A S A T H
34
21.4%
NC_002935.2 and 10 others:
NC_016787.1 Lanthipeptides: allorf_0696604_0696828_lanthipeptide NC_016788.1 Lanthipeptides: allorf_0704780_0705004_lanthipeptide NC_016790.1 Lanthipeptides: allorf_0673912_0674136_lanthipeptide NC_016802.1 Lanthipeptides: allorf_0720358_0720582_lanthipeptide NZ_CP038504.1 Lanthipeptides: allorf_0568170_0568394_lanthipeptide NZ_CP040519.1 Lanthipeptides: allorf_0699626_0699850_lanthipeptide NZ_CP040557.1 Lanthipeptides: allorf_0664205_0664429_lanthipeptide NZ_MIOA01000032.1 Lanthipeptides: allorf_03743_03967_lanthipeptide NZ_MIOB01000009.1 Lanthipeptides: allorf_03741_03965_lanthipeptide NZ_MIYS01000053.1 Lanthipeptides: allorf_04053_04277_lanthipeptide
Lanthipeptides: allorf_0736323_0736547_lanthipeptide
1
R N A V Y F K Y Y H P I R I C S W I T S P R P H D R
26
N + + R C W I T+P H R
17
E N L A A V R G W Q T F R C C V W I T A P G V H K R
42
20.6%
NZ_CP029361.1 and 1 other:
NZ_LZRD01000031.1 Lanthipeptides: allorf_12002_12133_lanthipeptide
Lanthipeptides: allorf_5021393_5021590_lanthipeptide
18
I T S P R P H D R R S V A S A
32
+ +P R P D R V S
4
V L A P R P R D R P R V T S G
18
with 2 more sequence matches
16.7%
NZ_OCTY01000002.1:
Lanthipeptides: allorf_0873960_0874184_lanthipeptide
15
C S W I T S P R P H D
25
C T S P R P D
21
C L L Y T S P R P R D
31
13.7%
NZ_CP076103.1:
Lanthipeptides: allorf_5471922_5472122_lanthipeptide
10
H P I R I C S W I T S P R P H D R
26
P I +W I T D R
28
E P I A Q A T W I T C A E V C D R
44
allorf_383169_383288
Leader:
MLFISNTTILLESVRGS
Core:
R R R D H T T D A Q W R R P L T D C S L P V
Core with dehydrations:
R R R D H Dhb Dhb D A Q W R R P L Dhb D Cys Dha L P V

#### antiSMASH-DB 4.0 matches for allorf_383169_383288

100.0%
NZ_CP096021.1:
Lanthipeptides: allorf_383169_383288_lanthipeptide
1
R R R D H T T D A Q W R R P L T D C S L P V
22
R R R D H T T D A Q W R R P L T D C S L P V
1
R R R D H T T D A Q W R R P L T D C S L P V
22
27.3%
NZ_BFCH01000018.1:
Lanthipeptides: allorf_0588167_0588340_lanthipeptide
12
R R P L T D C S L P
21
R+P L C S P
3
R K P L W I C S F P
12
22.9%
NZ_CP095740.1:
Lanthipeptides: allorf_1761025_1761225_lanthipeptide
2
R R D H T T D A Q W R R P L T D C S L P
21
R R + R R P D S+P
11
R R S C L A R S P L R R P F A D A S V P
30
with 3 more sequence matches
19.4%
NZ_JAIHOO010000001.1:
Lanthipeptides: K4L06_RS15915_lanthipeptide
9
A Q W R R P L T D C S L P V
22
A L T D S L P+
7
A S T E A A L T D T S L P L
20
17.8%
NZ_CP067396.1:
Lanthipeptides: allorf_5288223_5288408_lanthipeptide
1
R R R D H T T D A Q W R R P L T D C S L P
21
+R R D + W R L L P
22
K R R D R E S S R S W R F F L A C F F L P
42
16.7%
NZ_CP041650.2:
Lanthipeptides: allorf_01112484_01112708_lanthipeptide
3
R D H T T D A Q W R R P
14
R H+ A W R P
12
R S H S C R A P W E R P
23
allorf_392974_393144
Leader:
MMSATQSSGM
Core:
S Y K L M N T D L K S E F D S E F E T D D D L D S Q R A A T A F L C A T D F C T Y T P G C P
Core with dehydrations:
Dha Y K L M N Dhb D L K Dha E F D Dha E F E Dhb D D D L D Dha Q R A A Dhb A F L Cys A Dhb D F Cys Dhb Y Dhb P G Cys P

#### antiSMASH-DB 4.0 matches for allorf_392974_393144

100.0%
NZ_CP096021.1:
Lanthipeptides: allorf_392974_393144_lanthipeptide
1
S Y K L M N T D L K S E F D S E F E T D D D L D S Q R A A T A F L C A T D F C T Y T P G C P
46
S Y K L M N T D L K S E F D S E F E T D D D L D S Q R A A T A F L C A T D F C T Y T P G C P
1
S Y K L M N T D L K S E F D S E F E T D D D L D S Q R A A T A F L C A T D F C T Y T P G C P
46
24.5%
NZ_KZ859514.1:
Lanthipeptides: DPQ64_RS18690_lanthipeptide
7
T D L K S E F D S E F E T D D D L D S Q R A A T A F L C A T D F C
39
T++K F D F E + + A T L T D C
6
T E I K G V F D E R F E---E Y T E K I A G T W T L G C T D T C
35
19.6%
NZ_MLKL01000042.1:
Lanthipeptides: BKK45_RS27405_lanthipeptide
14
D S E F E T D D D L D S Q R A A T A F L C A T D F C T
40
D E T + A + L C T C T
2
D V N P E T T P A T P T I V A V S V K L C P T G V C T
28
with 2 more sequence matches
14.0%
NZ_CP019286.1:
Lanthipeptides: allorf_097046_097228_lanthipeptide
1
S Y K L M N T D L K S E F D S E F E
18
++K +++L K F D +F E
1
A H K Q R D S E L K V I F D D Q F E
18
13.7%
NZ_CP019286.1:
Lanthipeptides: allorf_097362_097547_lanthipeptide
1
S Y K L M N T D L K S E F D S E F E
18
++K +++L K+ F D +F E
1
A H K Q R D S E L K A I F D D Q F E
18

#### MIBiG 4.0 matches for allorf_392974_393144

10.9%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
28
A A T A F L C A T D F C T
40
+A C T C T
22
G V S A A F C P T T K C T
34
allorf_392980_393156
Leader:
MRQYLWTTWSVRAEICGA
Core:
Q K C S G C T L T V E I I I C F E L A I K L T L K V G I H Q F V R H A R R L G C
Core with dehydrations:
Q K Cys Dha G Cys Dhb L Dhb V E I I I Cys F E L A I K L Dhb L K V G I H Q F V R H A R R L G Cys

#### antiSMASH-DB 4.0 matches for allorf_392980_393156

100.0%
NZ_CP096021.1:
Lanthipeptides: allorf_392980_393156_lanthipeptide
1
Q K C S G C T L T V E I I I C F E L A I K L T L K V G I H Q F V R H A R R L G C
40
Q K C S G C T L T V E I I I C F E L A I K L T L K V G I H Q F V R H A R R L G C
1
Q K C S G C T L T V E I I I C F E L A I K L T L K V G I H Q F V R H A R R L G C
40

#### MIBiG 4.0 matches for allorf_392980_393156

15.0%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
6
C T L T V E I I
13
C T L T V E +
17
C T L T V E C M
24
allorf_395792_395974
Leader:
MLDAVGNRPSPAWRGGRSTSDNANQGDAVILDEFSFM
Core:
R C Y Q S Q I T S R V F A S G Q S H P D L Q I
Core with dehydrations:
R Cys Y Q Dha Q I Dhb Dha R V F A Dha G Q Dha H P D L Q I

#### antiSMASH-DB 4.0 matches for allorf_395792_395974

100.0%
NZ_CP096021.1:
Lanthipeptides: allorf_395792_395974_lanthipeptide
1
R C Y Q S Q I T S R V F A S G Q S H P D L Q I
23
R C Y Q S Q I T S R V F A S G Q S H P D L Q I
1
R C Y Q S Q I T S R V F A S G Q S H P D L Q I
23
20.0%
NZ_CM002330.1:
Lanthipeptides: allorf_5797326_5797457_lanthipeptide
6
Q I T S R V F A S G Q S H P D L
21
Q+T R+ +S H D L
14
Q L T E R L R E Q A R S H G D L
29
allorf_398029_398259
Leader:
MVTVAMDHVDERLRVHPFVIGLSGHVRMVHLEDDRFSGVYAFILRVLLSFSDCAMVVTAA
Core:
T N S P R S L S V P S A C D R W
Core with dehydrations:
Dhb N Dha P R Dha L Dha V P Dha A Cys D R W

#### antiSMASH-DB 4.0 matches for allorf_398029_398259

100.0%
NZ_CP096021.1:
Lanthipeptides: allorf_398029_398259_lanthipeptide
1
T N S P R S L S V P S A C D R W
16
T N S P R S L S V P S A C D R W
1
T N S P R S L S V P S A C D R W
16
40.0%
NC_013729.1:
Lanthipeptides: allorf_6984235_6984345_lanthipeptide
4
P R S L S V P S A C D R
15
P R+L S P+A C R
9
P R A L S E P A A C R R
20
34.8%
NZ_ML219773.1:
Lanthipeptides: EPL03_RS19855_lanthipeptide
1
T N S P R S L S V P S A C
13
T+ P S L S V A C
1
T S C P E S L S V Q P A C
13
with 1 more sequence matches
18.9%
NC_017030.1:
Lanthipeptides: allorf_07549085_07549255_lanthipeptide
6
S L S V P S A C D R
15
S L S P S C R
9
S L S A P S G C Q R
18
allorf_398228_398356
Leader:
MKQSSQPQRRRSRCGRTRRILAS
Core:
V G R T E A V G L L G D G S D G S C G
Core with dehydrations:
V G R Dhb E A V G L L G D G Dha D G Dha Cys G

#### antiSMASH-DB 4.0 matches for allorf_398228_398356

100.0%
NZ_CP096021.1:
Lanthipeptides: allorf_398228_398356_lanthipeptide
1
V G R T E A V G L L G D G S D G S C G
19
V G R T E A V G L L G D G S D G S C G
1
V G R T E A V G L L G D G S D G S C G
19
17.9%
NZ_CP102267.1:
Lanthipeptides: allorf_0904640_0904792_lanthipeptide
3
R T E A V G L L G D G S D G S C
18
R T E V +L G+ C
6
R T E Y V F I L G E V R C T Y C
21
allorf_398794_398988
Leader:
MPLPRLWRLRRFDTPRLDRLLMEVSYS
Core:
S L P R I Y N Y G I G L P L R S A A T V S I R F S L L E Q L C S C S E Q L
Core with dehydrations:
Dha L P R I Y N Y G I G L P L R Dha A A Dhb V Dha I R F Dha L L E Q L Cys Dha Cys Dha E Q L

#### antiSMASH-DB 4.0 matches for allorf_398794_398988

100.0%
NZ_CP096021.1:
Lanthipeptides: allorf_398794_398988_lanthipeptide
1
S L P R I Y N Y G I G L P L R S A A T V S I R F S L L E Q L C S C S E Q L
37
S L P R I Y N Y G I G L P L R S A A T V S I R F S L L E Q L C S C S E Q L
1
S L P R I Y N Y G I G L P L R S A A T V S I R F S L L E Q L C S C S E Q L
37
25.6%
NZ_CP048890.1 and 1 other:
NZ_CP071478.1 Lanthipeptides: allorf_32129_32302_lanthipeptide
Lanthipeptides: allorf_13941_14114_lanthipeptide
9
G I G L P L R S A A T V S I R F S L L E Q L C S C S E Q L
37
G I L P L+ V + + +L S C E L
14
G I T L P L Q L V Q K V I Y K L Q V N P K L N S C V E I L
42
21.6%
NZ_AP023354.1:
Lanthipeptides: allorf_6883246_6883380_lanthipeptide
3
P R I Y N Y G I G L P L R S A A T V
20
P G I L P L R S ++
13
P P F G G A G I A L P L R S T G S L
30
with 2 more sequence matches
20.5%
NZ_AP025692.1 and 14 others:
NZ_AP025692.1 Lanthipeptides: allorf_0069478_0069666_lanthipeptide NZ_CP047147.1 Lanthipeptides: allorf_0132945_0133133_lanthipeptide NZ_CP047147.1 Lanthipeptides: allorf_0132945_0133133_lanthipeptide NZ_CP056773.1 Lanthipeptides: allorf_6887512_6887700_lanthipeptide NZ_CP056773.1 Lanthipeptides: allorf_6887512_6887700_lanthipeptide NZ_CP079112.1 Lanthipeptides: allorf_0069403_0069606_lanthipeptide NZ_CP079112.1 Lanthipeptides: allorf_0069403_0069606_lanthipeptide NZ_JAHUVY010000001.1 Lanthipeptides: allorf_0075041_0075244_lanthipeptide NZ_JAHUVY010000001.1 Lanthipeptides: allorf_0075041_0075244_lanthipeptide NZ_KB890710.1 Lanthipeptides: allorf_068944_069132_lanthipeptide NZ_KB890710.1 Lanthipeptides: allorf_068944_069132_lanthipeptide NZ_OX371412.1 Lanthipeptides: allorf_0056080_0056268_lanthipeptide NZ_VOGX01000034.1 Lanthipeptides: allorf_1079300_1079488_lanthipeptide NZ_VOGX01000034.1 Lanthipeptides: allorf_1079300_1079488_lanthipeptide
Lanthipeptides: allorf_0069478_0069666_lanthipeptide
3
P R I Y N Y G I G L P L R S A A T V S I R
23
P R ++ G G+P+R S+R
16
P R G H S-G T G M P V R E G V D K S L R
35
15.1%
NZ_CP029607.1:
Lanthipeptides: allorf_6462155_6462382_lanthipeptide
3
P R I Y N Y G I G L P L R S A A T V S I R
23
P ++N G G L P + S R
2
P F V W N L G F G L P E T T G P D C S A R
22

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

allorf_381222_381323 - Class II
  Cleavage pHMM score: -6.20
  RODEO score: 0
  Monoisotopic mass: 1204.5 Da
  Molecular weight: 1205.4 Da
  Number of bridges: 1
allorf_381296_381424 - Class II
  Cleavage pHMM score: -7.20
  RODEO score: 0
  Monoisotopic mass: 3939.2 Da
  Molecular weight: 3941.6 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3959.6 Da N = 1
    3977.6 Da N = 2
    3995.6 Da N = 3
allorf_381863_381931 - Class II
  Cleavage pHMM score: -6.50
  RODEO score: 0
  Monoisotopic mass: 1142.5 Da
  Molecular weight: 1143.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1161.3 Da N = 1
allorf_383135_383269 - Class II
  Cleavage pHMM score: -3.10
  RODEO score: 0
  Monoisotopic mass: 3976.1 Da
  Molecular weight: 3978.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3996.5 Da N = 1
    4014.5 Da N = 2
    4032.5 Da N = 3
    4050.6 Da N = 4
    4068.6 Da N = 5
allorf_383169_383288 - Class II
  Cleavage pHMM score: -4.50
  RODEO score: 0
  Monoisotopic mass: 2606.4 Da
  Molecular weight: 2607.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2625.9 Da N = 1
    2643.9 Da N = 2
    2662.0 Da N = 3
allorf_392974_393144 - Class II
  Cleavage pHMM score: -6.30
  RODEO score: 0
  Monoisotopic mass: 4981.2 Da
  Molecular weight: 4984.4 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5002.4 Da N = 1
    5020.4 Da N = 2
    5038.4 Da N = 3
    5056.4 Da N = 4
    5074.5 Da N = 5
    5092.5 Da N = 6
    5110.5 Da N = 7
allorf_392980_393156 - Class II
  Cleavage pHMM score: -3.50
  RODEO score: 0
  Monoisotopic mass: 4424.5 Da
  Molecular weight: 4427.4 Da
  Number of bridges: 4
allorf_395792_395974 - Class II
  Cleavage pHMM score: -5.20
  RODEO score: 0
  Monoisotopic mass: 2530.3 Da
  Molecular weight: 2531.8 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2549.8 Da N = 1
    2567.8 Da N = 2
    2585.8 Da N = 3
    2603.9 Da N = 4
allorf_398029_398259 - Class II
  Cleavage pHMM score: -6.80
  RODEO score: 0
  Monoisotopic mass: 1684.8 Da
  Molecular weight: 1685.8 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1703.9 Da N = 1
    1721.9 Da N = 2
    1739.9 Da N = 3
    1757.9 Da N = 4
allorf_398228_398356 - Class II
  Cleavage pHMM score: -6.50
  RODEO score: 0
  Monoisotopic mass: 1694.8 Da
  Molecular weight: 1695.8 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1713.8 Da N = 1
    1731.8 Da N = 2
allorf_398794_398988 - Class II
  Cleavage pHMM score: -6.30
  RODEO score: 0
  Monoisotopic mass: 3971.1 Da
  Molecular weight: 3973.6 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3991.6 Da N = 1
    4009.6 Da N = 2
    4027.7 Da N = 3
    4045.7 Da N = 4
    4063.7 Da N = 5