LOCUS       NZ_JALDUX010000005     12154 bp    DNA     linear   CON 12-MAY-2024
DEFINITION  Streptococcus mitis strain S25 NODE_5_length_127762_cov_208.989615,
            whole genome shotgun sequence.
ACCESSION   NZ_JALDUX010000005
VERSION     NZ_JALDUX010000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus mitis
  ORGANISM  Streptococcus mitis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 127762)
  AUTHORS   Palmer,K., Luke,J. and Madison,Y.
  TITLE     Whole genome sequencing of viridans group streptococci associated
            with infective endocarditis and the human mouth
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 127762)
  AUTHORS   Palmer,K., Luke,J. and Madison,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-MAR-2022) Biological Sciences, The University of Texas
            at Dallas, 800 W Campbell Rd, BSB 12, Richardson, TX 75080, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 209x
            Sequencing Technology             :: Illumina NextSeq 500
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023109755.1-RS_2024_05_12
            Annotation Date                   :: 05/12/2024 04:19:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,953
            CDSs (total)                      :: 1,906
            Genes (coding)                    :: 1,839
            CDSs (with protein)               :: 1,839
            Genes (RNA)                       :: 47
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 41
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 67
            CDSs (without protein)            :: 67
            Pseudo Genes (ambiguous residues) :: 0 of 67
            Pseudo Genes (frameshifted)       :: 23 of 67
            Pseudo Genes (incomplete)         :: 45 of 67
            Pseudo Genes (internal stop)      :: 16 of 67
            Pseudo Genes (multiple problems)  :: 16 of 67
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:27:13
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 10102
            Orig. end                         :: 22256
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JALDUX010000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..12154
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..12154
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12154
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:7154](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7154
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(388..402)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 20.05"
                     /tool="antismash"
     misc_feature    855..870
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.58"
                     /tool="antismash"
     misc_feature    982..1002
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 25.3"
                     /tool="antismash"
     gene            1265..2434
                     /locus_tag="M1F92_RS08405"
     CDS             1265..2434
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (31-382). E-value: 2e-64.
                     Score: 209.9. Matches aSDomain:
                     nrpspksdomains_M1F92_RS08405_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519430.1"
                     /locus_tag="M1F92_RS08405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="WP_004257696.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 3.5e-64, bitscore:
                     210.1, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 1.8e-08, bitscore:
                     26.6, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.5e-08,
                     bitscore: 27.1, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLTKRFNKQLDKIQVSLIRQFDQAISEIPGVLRLTLGEPDFTTP
                     DHIKEAAKRAIDQNQSYYTGMSGLLTLRKAASDFVKEKYQLDYDPENEILVTIGATEAL
                     SATLTAILEEGDKVLLPAPAYPGYEPIVNLVGAEIVEIDTTENGFVLTPEMLEKAILEQ
                     GDKLKAVILNYPANPTGITYSREQLEALAAVLRKYEIFVVCDEVYSELTYTGEAHVSLG
                     TMLRDQAIIINGLSKSHAMTGWRLGLIFAPAAFTAQLIKSHQYLVTAANTMAQHAAVEA
                     LTAGKNDAEPMKKEYIQRRDYIIEKMTALGFEIIKPDGAFYIFAKIPAGYNQDSFAFLK
                     DFAQKKAVAFIPGAAFGRYGEGYVRLSYAASMETIKEAMKRLEEYMREA"
     aSDomain        1358..2410
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_M1F92_RS08405_Aminotran_1_2.1"
                     /evalue="2.00E-64"
                     /label="M1F92_RS08405_Aminotran_1_2.1"
                     /locus_tag="M1F92_RS08405"
                     /protein_end="382"
                     /protein_start="31"
                     /score="209.9"
                     /tool="antismash"
                     /translation="VLRLTLGEPDFTTPDHIKEAAKRAIDQNQSYYTGMSGLLTLRKAA
                     SDFVKEKYQLDYDPENEILVTIGATEALSATLTAILEEGDKVLLPAPAYPGYEPIVNLV
                     GAEIVEIDTTENGFVLTPEMLEKAILEQGDKLKAVILNYPANPTGITYSREQLEALAAV
                     LRKYEIFVVCDEVYSELTYTGEAHVSLGTMLRDQAIIINGLSKSHAMTGWRLGLIFAPA
                     AFTAQLIKSHQYLVTAANTMAQHAAVEALTAGKNDAEPMKKEYIQRRDYIIEKMTALGF
                     EIIKPDGAFYIFAKIPAGYNQDSFAFLKDFAQKKAVAFIPGAAFGRYGEGYVRLSYAAS
                     METIKEAMKRL"
     gene            2431..3201
                     /gene="recO"
                     /locus_tag="M1F92_RS08410"
     CDS             2431..3201
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recO"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000616164.1"
                     /locus_tag="M1F92_RS08410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNA repair protein RecO"
                     /protein_id="WP_247933137.1"
                     /transl_table=11
                     /translation="MIQSITSQGLVLYNRNFREDDKLVKIFTEQAGKRMFFVKHAGQSK
                     LAPVIQPLVLARFLLRINDDGLSYIEDYHEVMTFPKINSDLFVMAYATYVAALTDASLQ
                     DNQQDAPLFAFLQKTLELMEEGLDYQVLTNIFEIQILTRFGISLNFNECVFCHRIGQAF
                     DFSFKYGACLCPEHYHEDERRCHLNPNIPYLLNQFQAIDFETLETISLKPEIKQELRKF
                     MDQLYEEYVGIHLKSKKFIDSLADWGQLLKEEKK"
     gene            3198..4190
                     /gene="plsX"
                     /locus_tag="M1F92_RS08415"
     CDS             3198..4190
                     /EC_number="2.3.1.274"
                     /GO_function="GO:0043811 - phosphate:acyl-[acyl carrier
                     protein] acyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0008610 - lipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="plsX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000717456.1"
                     /locus_tag="M1F92_RS08415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphate acyltransferase PlsX"
                     /protein_id="WP_078238230.1"
                     /transl_table=11
                     /translation="MKKIAVDAMGGDYAPQAIVEGVNQALADFSDIEVQLYGDESKIKQ
                     YLTATERVSIIHTDEKIDSDDEPTRAIRKKKNASMVLAAKAVKEGEADAVLSAGNTGAL
                     LAAGFFIVGRIKNIDRPGLMSTLPTVDGKGFDMLDLGANAENTAHHLHQYAVLGSFYAK
                     NVRGIAQPRVGLLNNGTESSKGDPLRKETYELLAADESLNFIGNVEARDLMNGVADVVV
                     TDGFTGNAVLKSIEGTAMGIMGLLKTAITGGGLRAKLGALLLKDSLRGLKKQLNYSDVG
                     GAVLFGVKAPVVKTHGSSDAKAVYSTIRQIRTMLETDVVAQTAREFSGE"
     gene            4196..4432
                     /locus_tag="M1F92_RS08420"
     CDS             4196..4432
                     /NRPS_PKS="Domain: PP-binding (8-73). E-value: 2.6e-11.
                     Score: 35.6. Matches aSDomain:
                     nrpspksdomains_M1F92_RS08420_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009014476.1"
                     /locus_tag="M1F92_RS08420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl carrier protein"
                     /protein_id="WP_020902253.1"
                     /sec_met_domain="PP-binding (E-value: 1e-11, bitscore:
                     38.1, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding_2 (E-value: 1.2e-05, bitscore:
                     18.5, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEKEIFDRIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEFI
                     LTLEDEFSIEISDEEIDQLQSVGDVVEVVKSKE"
     aSDomain        4220..4414
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_M1F92_RS08420_PP-binding.1"
                     /evalue="2.60E-11"
                     /label="M1F92_RS08420_PP-binding.1"
                     /locus_tag="M1F92_RS08420"
                     /protein_end="73"
                     /protein_start="8"
                     /score="35.6"
                     /tool="antismash"
                     /translation="RIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEFILTLEDEFS
                     IEISDEEIDQLQSVGDVVEV"
     misc_feature    complement(4484..4499)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 21.84"
                     /tool="antismash"
     misc_feature    complement(4528..4541)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.96"
                     /tool="antismash"
     misc_feature    4596..4605
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     misc_feature    4597..4610
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.35"
                     /tool="antismash"
     misc_feature    complement(4598..4611)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.88"
                     /tool="antismash"
     gene            4654..4842
                     /locus_tag="M1F92_RS08425"
     CDS             4654..4842
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269957.1"
                     /locus_tag="M1F92_RS08425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_033680983.1"
                     /transl_table=11
                     /translation="MNKILKYFLVFVFLFLMNIFIFKILATLGFQLTMSEKSYIVPPLF
                     SIIVLYMIDKRIRKKKK"
     gene            5001..7154
                     /gene="comA"
                     /locus_tag="M1F92_RS08430"
     CDS             5001..7154
                     /codon_start=1
                     /gene="comA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000668284.1"
                     /locus_tag="M1F92_RS08430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptide cleavage/export ABC transporter"
                     /protein_id="WP_247933138.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 3e-43, bitscore:
                     139.8, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1130.3,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFGKRHYRSQVDQMDCGVASLAMVFGYYGSYYSLAHLRELAKTT
                     MDGTTALGLVKVAEEVGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVIGQD
                     KDSIHIADPDPEVKLTKLPRERFAEEWTGVTLFMAPSPDYKPHKDQKNGLLSFIPILVK
                     QRGLIANIVLATLLVTLINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQIL
                     SYAQEYLLLVLGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALAS
                     TILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNRDTMEAN
                     AVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAH
                     LLLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRL
                     NEVYLVASEFEEKKTVEDLSLMKGDMTFKNVHYKYGYGRDVLSDINLTIPQGSKVTFVG
                     ISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYINYLPQQPYVFNGTILE
                     NLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARA
                     LLTDAPVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGK
                     IVEEGKHADLLAQGGFYAHLVNS"
     gene            7167..8516
                     /gene="comB"
                     /locus_tag="M1F92_RS08435"
     CDS             7167..8516
                     /codon_start=1
                     /gene="comB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801614.1"
                     /locus_tag="M1F92_RS08435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HlyD family secretion protein"
                     /protein_id="WP_247933139.1"
                     /transl_table=11
                     /translation="MKPEFLESAEFYNRRYHNFSSRVIVPMFLLLVFLLGFATFAEKEI
                     SLSTRATVEPSRILVNIQSTSNNRILVNHLEENKLVKKGELLVQYQEGAEGVQAEAYAS
                     QLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQNETI
                     ASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAIETGASLASQNLAYSLYQSYKSQGE
                     ENSQAKAQTISQVEAHLSQLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLARV
                     GQELTLLDQKILETESGKKVQGNLLDKGKITASEDGVLHLNPETSDSTMVAEGALLAQL
                     YPSLEKEETAKLTAYLSSKDVARIKVGDSVRYTTTHDAKNQLFLDSTITSIDATATKTE
                     KGNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDHFLNKE"
     gene            8686..9393
                     /gene="purC"
                     /locus_tag="M1F92_RS08440"
     CDS             8686..9393
                     /EC_number="6.3.2.6"
                     /GO_function="GO:0004639 -
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009152 - purine ribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="purC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002312208.1"
                     /locus_tag="M1F92_RS08440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="WP_101782702.1"
                     /transl_table=11
                     /translation="MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGK
                     GVLNNQISSFIFEKLNAAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSKRF
                     GVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIADDQQIAYLKEETRRINELLKV
                     WFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLGELTD
                     VYEVVWEKLQGLK"
     gene            9404..9538
                     /locus_tag="M1F92_RS09785"
     CDS             9404..9538
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429437.1"
                     /locus_tag="M1F92_RS09785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_049544729.1"
                     /transl_table=11
                     /translation="MENLRLSTKRTQAEKVPQTFSLRRGLGELTDVYEIVWEKLQELK"
     misc_feature    complement(10891..10905)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.9"
                     /tool="antismash"
     misc_feature    complement(11370..11385)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.09"
                     /tool="antismash"
     misc_feature    complement(11982..11997)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 20.85"
                     /tool="antismash"
ORIGIN
        1 agagaggcaa ggataaagta aaggataaaa agtgggaaga cttttttcag ttgtaggctt
       61 tgcttgtttt cttgttggcg actttgccag taggatagaa agagcgtgat agggataatg
      121 gccaaagtac gtgtgagttt aacaatggtt gcagactcga gggtattggt ctggtagaga
      181 ctatcccagg cgctagctgt ggcggttaca gaggaagtat cattgactgc agttcctgca
      241 aagagggcga agccgtcatt ggatagatga agccaggtgc cgagggttgg aaagatgagc
      301 gcagccaaga cattgaagaa aaagataacg gagatggctt gggctacttc cttttcctta
      361 gcatggataa cgggcgctgt tgccgcaatg gcagagcccc cacagataga agaacctact
      421 ccaatcaagg tagccagttt tgtgtccagt gcaaagaagc gctggaaaag ataggcaaca
      481 atcaaggcta ttgaaatggt ggacaggatg acagggagtg aagattgccc aactgcgaag
      541 acttgcgaga tattgagacc aaaaccaagc aagataacgg catactggag caatttttta
      601 gaactaaagg tcaacccagc atccagttgt ttataggacg agagaaaggg atgtaggagc
      661 atgcctatga aaatggcaaa aacgggcgcg ccaataacag ggaagaatcc tcctaagtac
      721 caagatagaa tggaaatgag aaggcaggcc aagatgcctg ctccattttt tgatagaaat
      781 gacataaaaa cctccaaata gaatctgtta ccattataga cctgtagaga ggaaaagtaa
      841 aatagaaagt ggagctaaca attatttgac aagtagtgct aattatgtaa taataatcct
      901 acaagaactg taacgaagtc ttggcaaaaa caaaaatacc agagctccac ctctggtatt
      961 tctttttgtc cagttacatt aaaactaaac tcaggttata tttttttgtc gcgcttatct
     1021 aaccactttc tgactatcca ctcagaaatg acattaccgg taatagtaat cagtaatggt
     1081 gctagaataa ctgtaacgaa gattagcaaa aactcacctc caaactaagt tcgttagtgg
     1141 agttgcgaca aatccatttt aacatacttc aatttgtcat gctagcgtta ttctatcatg
     1201 tatttttgcg gtcggggggc ttttgtagta taatagagat acgttttgaa agtaggaggt
     1261 atctatggac ttaactaagc gctttaataa acagttagat aagattcaag tttcgttgat
     1321 tcgtcaattt gaccaggcta tttcggagat tcctggggtc ttgcgtttga ccttggggga
     1381 gcctgatttt acaacgccag atcatatcaa ggaggcggcc aagcgagcga ttgatcagaa
     1441 ccaatcctac tatacaggga tgagtggtct gctgactcta cgtaaggcgg ccagtgactt
     1501 tgttaaggaa aagtaccaac tggactatga tcctgaaaat gaaatcttgg ttacaattgg
     1561 ggcgacagag gctttatctg ctactttgac ggctattttg gaagagggag acaaggtact
     1621 tttgccagct cctgcctatc caggttatga accgattgtc aatctagttg gggcagagat
     1681 tgtcgagatt gacacaactg aaaatggttt tgtcttgact cctgaaatgt tggagaaggc
     1741 cattttggag cagggtgaca agctcaaggc ggttattctc aactatccag ccaatccgac
     1801 aggaattacc tacagtcggg aacaattgga ggccttggca gctgttttac gcaagtatga
     1861 gatttttgtt gtctgtgatg aggtttactc agaattgacc tacacaggcg aagcccatgt
     1921 gtctctggga accatgttga gagatcaggc tattattatc aatggtctat ctaaatcgca
     1981 tgccatgaca ggttggcgtt tgggtctgat ttttgctcct gcagccttta cagctcagtt
     2041 gattaagagt caccagtact tggttactgc cgcaaatact atggctcaac atgctgcggt
     2101 ggaggccttg acggctggta aaaatgatgc ggagcctatg aagaaggaat acatccagcg
     2161 gcgggactat attatcgaga aaatgactgc tcttggtttt gagattatca aaccagacgg
     2221 tgccttctat atctttgcta agattccagc gggttacaat caagattctt ttgcttttct
     2281 gaaggatttt gctcagaaga aggctgttgc ctttattcct ggtgctgcct ttgggcgtta
     2341 tggagaagga tatgttcgcc tatcttatgc agccagcatg gagactatca aagaagccat
     2401 gaaacgactt gaggagtaca tgagagaagc atgattcagt ctatcacgag tcaaggcttg
     2461 gtgctttata atcgcaattt tcgtgaggat gacaagctag tcaagatttt tactgaacag
     2521 gctggcaagc gcatgttttt tgtcaaacac gctggtcagt ctaagctggc tcctgttatt
     2581 caacccttgg tgctggctcg atttctctta cgaatcaatg atgacgggct tagctacatt
     2641 gaggactatc atgaggtgat gacctttcca aagattaata gcgatctctt tgtcatggcc
     2701 tatgcgacct acgtggcggc tcttacagat gctagtttgc aggacaatca gcaggatgct
     2761 cccttgtttg cttttttgca aaaaactttg gagttgatgg aagagggatt ggattatcaa
     2821 gttttgacca atatttttga aattcaaatc ttgactcgat ttgggattag tctcaatttt
     2881 aatgagtgtg ttttttgtca tcggatcggt caggcttttg acttttcttt caaatatgga
     2941 gcctgcctct gtccagaaca ttatcatgaa gatgagagac gttgccatct caatcctaat
     3001 atcccttatt tgctcaatca gtttcaagcc attgattttg agaccttgga gaccatttcg
     3061 ctcaagcctg aaatcaagca agagctacgc aaatttatgg atcaactata cgaagagtac
     3121 gttgggattc acctaaaatc aaagaaattt attgattccc tagcagactg gggacaatta
     3181 ctaaaagagg aaaagaaatg aaaaaaatcg cagtagatgc catggggggc gattacgcac
     3241 ctcaagccat cgttgagggt gtcaatcaag ccctagctga cttttcagat attgaggttc
     3301 aactctatgg agatgaaagc aaaatcaagc aatatctaac agcgacagag cgcgtcagca
     3361 ttatccatac ggatgagaag attgattcag acgatgaacc tacgagagct attcggaaga
     3421 agaaaaatgc cagtatggtc ttggcggcca aggctgtcaa agagggagaa gcagacgctg
     3481 ttctctcagc tgggaataca ggtgctttac tagcagcagg atttttcatc gtgggtcgta
     3541 tcaagaacat cgatcgtcct gggcttatgt cgactttgcc gactgtagat gggaaggggt
     3601 ttgacatgct ggacctcggt gccaatgcgg aaaatacagc acatcacctc catcaatacg
     3661 cggttctagg ttccttctat gctaaaaatg ttcgtggaat tgcgcaacca cgcgttggct
     3721 tgctcaataa cggaacagag agtagtaagg gcgacccgct tcgtaaggaa acctacgaat
     3781 tactagcagc tgatgaaagt ttaaacttta tcggaaacgt ggaagcgcgt gatttgatga
     3841 atggcgttgc agatgttgtt gtgacagatg gtttcacggg aaacgctgtg ctcaaatcca
     3901 ttgaaggaac agctatggga atcatgggct tactcaagac cgctattaca ggtggaggtc
     3961 ttcgagcgaa actaggcgcc ctccttctca aggacagcct cagaggtttg aaaaaacagc
     4021 tcaactactc agatgttggt ggagcagtct tgtttggtgt caaggcaccg gttgtcaaga
     4081 ctcatggctc aagcgatgcc aaggctgttt atagtacaat ccgccagatt cgtaccatgc
     4141 tagaaacaga cgtagttgcc cagactgcgc gtgaattttc aggagaataa aagagatgac
     4201 agaaaaagaa atttttgacc gtattgtgac cattatccaa gagcgacagg gagaggactt
     4261 tgtcgtgaca gaatccttga gtctgaaaga cgacttggat gctgactcag ttgacttgat
     4321 ggagtttatc ttgacgctgg aagatgaatt tagcatcgaa atcagtgacg aggaaattga
     4381 tcaactgcaa agtgtaggcg atgtggtaga agtcgtcaaa agtaaagaat agcaagataa
     4441 gagtagttgt atgttgctaa gaatgtagct caacattcta tttgacaatt atttacattt
     4501 taatcttttt aaatatatat tttaggtaga acgcttattc tgcctatttt ttgccaaaaa
     4561 agtgtagttg agctgtttat ttggagtttt acatgtattt tttgataaaa tttgataaaa
     4621 taggtataga aattaggaga gttgaagaaa aaaatgaata agattttaaa atatttttta
     4681 gtatttgttt ttctattttt aatgaatatt ttcatcttta agatactagc aactctggga
     4741 tttcagctga caatgagtga aaagagttat attgtaccac cgctattttc gattatcgtt
     4801 ttgtacatga ttgacaaaag aattaggaag aaaaagaaat aaatatatat tttaggcatc
     4861 acgtttgttc tgcctatttt tttatccaaa aagtgcattt gggaggtaga taggcgcatt
     4921 tggggaggaa gtccagtttt tgtttaggga ttggggtaag ataggtatta tcagatgagt
     4981 ttagaaaaaa ggagatgaat atgaaatttg ggaaacgtca ctatcgttcg caggtggatc
     5041 agatggactg cggtgtagct tcattagcca tggtttttgg ctactatggt agttactatt
     5101 ctttggctca cttgcgagaa ctggccaaga cgaccatgga tgggacgacg gctttgggct
     5161 tggtcaaggt ggcagaggag gttggttttg agacgcgagc aattaaggcg gatatgacgc
     5221 tttttgactt gccagatttg acttttcctt ttgttgctca tgtgcttaag gaaggaaaat
     5281 tgctccacta ttatgtggta attgggcagg ataaggatag cattcatatt gccgatccag
     5341 atcctgaggt aaaattgacc aagctgccac gtgagcgttt tgcggaagaa tggacgggag
     5401 tgactctttt tatggcacct agtccagact ataagcctca taaggatcaa aagaatggtc
     5461 tgctctcttt tatccctata ttagtgaaac agcgtggttt gattgccaat atcgttttgg
     5521 caacactctt ggtaaccttg attaacattg tgggttctta ttatttgcag tctatcattg
     5581 atacctatgt gccagatcag atgcgttcga cgcttgggat tatttctatt gggctagtta
     5641 tcgtctatat tctccagcag atcttgtctt atgctcaaga gtatctcttg cttgttttgg
     5701 ggcaacgttt gtcgattgat gtgattttgt cctatatcaa gcatgttttt cacctgccta
     5761 tgtccttttt cgcgacacgc aggacagggg aaatcgtgtc tcgttttaca gatgctaaca
     5821 gtatcattga tgcgctggct tcgaccattc tttcgatttt cctagatgtg tcaacggttg
     5881 tcattatttc tcttgtttta ttttcacaaa ataccaatct ctttttcatg actttattgg
     5941 cacttcctat ctacacagtg attatctttg ccttcatgaa gccgtttgaa aagatgaatc
     6001 gggataccat ggaagccaat gcggttctgt cttcttctat cattgaggac atcaacggta
     6061 ttgagactat caagtctttg accagtgaaa gtcaacgtta ccaaaagatt gacaaggaat
     6121 ttgtggatta tctgaagaaa tcctttacct atagtcgggc agagagtcag caaaaggctc
     6181 tgaaaaaggt tgctcatctc ttacttaatg tcggtattct ctggatgggg gctgttttgg
     6241 ttatggatgg caagatgagt ttggggcagt tgattaccta taataccttg cttgtttact
     6301 ttacaaatcc tttggaaaat atcatcaatc tgcaaaccaa gcttcagaca gcgcaggttg
     6361 ccaataaccg tctgaatgag gtttatctgg tagcttctga gtttgaggag aagaaaacag
     6421 ttgaggatct gagcttgatg aagggagata tgaccttcaa gaatgttcac tacaagtatg
     6481 gttatggtag agacgtcttg tcagacatca atttgaccat tccgcagggt tctaaggtga
     6541 cttttgtggg gatttcaggg tcaggtaaga cgaccttggc caagatgatg gttaattttt
     6601 acgacccaag tcagggagaa attagtttgg gtggtgtcaa tctcaatcag attgataaaa
     6661 aggctttgcg ccagtacatc aactatctgc ctcaacagcc ctatgtcttt aacgggacga
     6721 ttttggagaa tcttcttttg ggagccaagg aggggacaac tcaggaagat atcttacggg
     6781 cggtcgagtt ggcagagatt cgggaggaca ttgagcgcat gcccctgaat taccagacag
     6841 aattgacttc ggatggggca ggaatttcag gtggccaacg gcagagaatc gctctggcgc
     6901 gtgctctctt gacagatgcg ccggtcttga ttttggacga ggcgaccagc agtttggata
     6961 ttctgacaga gaagcgaatt gtcgataatc ttatggcttt agacaagacc ttgattttca
     7021 ttgctcaccg attgaccatt gctgagcgga cagagaaggt ggttgttttg gatcagggca
     7081 agattgttga agaaggaaag catgctgatt tgcttgcaca gggtggattt tacgcccatt
     7141 tggtgaatag ctagaaagag gagaggatga aaccagaatt tttagaaagt gcggagtttt
     7201 ataatcgtcg ttaccataat ttttccagtc gggtgattgt ccccatgttc cttctgctcg
     7261 tgtttttgct tggctttgca acatttgcag agaaggagat aagtttatca actagagcta
     7321 ctgtcgagcc tagtcgtatc cttgtaaata tccagtcaac tagcaacaat cgcattcttg
     7381 tcaatcattt ggaagaaaat aagctggtta aaaagggaga actgttggtt caatatcaag
     7441 aaggggcaga gggtgtccaa gcggaggcct atgctagtca gttggacatg ctcaaggatc
     7501 aaaaaaagca attggagtat ttgcaaaaga gtctacaaga aggggagaac cattttccag
     7561 aggaggataa gtttggctac caagccacct ttcgcgacta catcagtcaa gcaggcagtc
     7621 ttagggctag tacatcgcaa caaaacgaga ccatcgcgtc ccagaatgca gcagctagcc
     7681 aaacccaagc cgaaatcggc aatctcatca gccaaacaga ggctaaaatt cgcgattacc
     7741 agacagctaa gtcagctatt gaaacaggtg cttccttggc cagtcagaat ctagcctact
     7801 ctctctacca gtcctacaag tctcagggcg aggaaaattc gcaagctaag gctcagacaa
     7861 tttcgcaggt ggaagcgcat ctttctcagt tagaatccag tcttgctact taccgtgttc
     7921 agtatgcagg ttcaggtacc cagcaagcct atgcgtcagg cttaagcagt caattagagt
     7981 cccttaaatc ccaacatttg gctagggtcg gtcaggaatt gacccttcta gaccagaaaa
     8041 tcttggagac agagtcaggt aagaaggttc agggaaacct tttagacaag gggaaaatta
     8101 cggcgagtga ggatggggtg cttcacctta atcctgagac cagtgattct accatggtag
     8161 cagaaggtgc cttactagcc caactctatc cgtctttgga aaaagaagag acagccaaac
     8221 tcacagctta tctcagttca aaagatgtag caagaatcaa ggttggtgat tctgttcgct
     8281 atacgacgac tcatgatgcc aagaatcaac ttttcctaga ttctactatt acaagtattg
     8341 atgcgacagc taccaagact gaaaaaggga atttctttaa aatcgaggca gagactaatc
     8401 taacttctga gcaagctgaa aaacttcgat atggtgtgga aggtcgtctg cagatgatta
     8461 caggtaagaa aagttacctg cgttattatt tggatcattt tttgaacaaa gagtaatgtt
     8521 cgtgttttta gagttaaatg attttaaaac tgtgagaaag attcttcttg cggttttttc
     8581 tttatgattt ttgaggttac tacgttattt attcggttaa attcttgtat ttttaggttt
     8641 tttatggtag aatgtgctca agtaatacga aaggcgaact ttaaaatgtc aaaacaattg
     8701 atctattcgg gaaaagctaa agatatctat acaactgagg atgaaaatct tattatttca
     8761 acttacaagg accaggcgac tgcttttaat ggtgttaaga aggagcagat tgcgggcaag
     8821 ggagtgttga ataatcagat ttcatctttt atttttgaga aattaaatgc ggctggtgtg
     8881 gcgactcact ttgtggagaa gctttcagac acggaacaac tcaataaaaa ggttaagatt
     8941 attcctttgg aagttgtgct tcgcaactat acagctggtt ccttttcaaa acgttttggt
     9001 gtggatgagg gaatcgcctt ggagactccg attgtcgaat tttactacaa aaatgatgat
     9061 ttggatgacc cgtttatcaa tgacgaacat gtgaaattcc tacagattgc ggatgaccag
     9121 cagattgcct acttgaagga agaaacccgt cgtatcaatg aacttttgaa agtctggttt
     9181 gctgagattg gcctcaagtt gattgacttt aagctagagt tcggttttga caaggatggc
     9241 aagattatct tagcagatga attttcacca gataactgcc gtttgtggga tgcggatggc
     9301 aaccacatgg ataaggatgt tttccgtagg ggattaggag agctaacaga cgtttacgaa
     9361 gttgtctggg agaagctgca aggtttgaaa taatctgttt gcaatggaaa accttcgtct
     9421 ctcaactaaa aggactcagg ctgaaaaggt cccccagacc ttttcactcc gtaggggatt
     9481 gggagaacta acagacgttt acgagattgt ctgggaaaag ttgcaagaat tgaaataaca
     9541 acctcaaggt cgttggaaca ttgtaagagc tgaaataaag gaataaggat tgatggataa
     9601 acgtattttt gttgagaaaa aggctgattt tcaggtcaag tcagagagtt tggttagaga
     9661 actccagcat aacttgggat tgtcaacttt gaaaagtatt cgtatcgtgc aggtttatga
     9721 tgtatttgac ttggctgagg acctgtttgc acctgcagag aaacacattt tctctgagca
     9781 ggtgacagac catgttttgg acgaagcggc tgtgcaggcg gatcttacca actatgcttt
     9841 ctttgctact gaaagcctgc cagggcagtt tgaccagcgt gcagcttctt cgcaagaagc
     9901 cttgcttttg ttgggaagtt cgagtgacgt gacagtcaac acagcccaac tgtacttagt
     9961 caataaagat attgatgcga ctgagttgga agcggtcaag aactacctgc tcaatccagt
    10021 tgattctcgt ttcaaagaca tcacgacagg gattgccaag caggaatttt cagagtcaga
    10081 taagaccatt ccaaaattga ctttctttga aagctataca gcagaagact ttgctcgcta
    10141 caaggctgag caagggatgg ccatggaagt ggatgatttg ctctttatcc aagactattt
    10201 caagtcaatc gagcgcgtgc cgacggaaac agaactcaag gttttggaca cttactggtc
    10261 tgaccactgc cgtcacacaa cttttgagac agagttgaaa cacattgact tctccgcatc
    10321 gaaattccaa aagcaattgc aggcgaccta tgacaaatat attgccatgc gtgaggattt
    10381 ggggcgttct gaaaaaccgc aaaccttgat ggatatggcg actattttcg gtcgttatga
    10441 gcgggctaat ggacgtttgg acgatatgga agtgtcagac gaaatcaatg cttgctcggt
    10501 cgaaatcgaa gtggatgtca atggtgtgaa agaaccatgg cttctcatgt tcaagaacga
    10561 aacccacaac cacccaacag aaatcgaacc atttggtggg gctgctacct gtatcggtgg
    10621 agccattcgt gatccattgt caggtcgttc ctacgtttat caagctatgc gtatctcggg
    10681 tgctggtgat attacagcac cgatttcgga aactcgtgct ggaaaattac cacaacaagt
    10741 catttctaag acagcggctc atggttattc ttcttacggg aatcagattg ggcttgcgac
    10801 gacctacgtt cgtgaatact tccacccagg ctttgtagct aaacgcatgg agctaggtgc
    10861 tgttgttggt gcggctccta agtgcaacgt tgtccgagaa aaaccggaag ctggtgatgt
    10921 cattattctc cttggtggca agacaggacg tgatggtgtc ggtggtgcga caggttcttc
    10981 caaggttcaa acagttgagt ctgtagagac tgctggagct gaggttcaaa aaggaaatgc
    11041 tatcgaagaa cgtaagattc aacgtctttt ccgtaatggt gaagtgacac gtctgatcaa
    11101 aaaatcaaat gactttggtg ctggtggtgt ctgtgtagct attggtgaat tagcagacgg
    11161 tcttgaaatc gacctcaaca aggtgcctct taaataccag ggcttgaatg gtaccgaaat
    11221 tgccatctct gaatctcaag aacggatggc agtcgtggtt cgtcctgagg atgtagatgc
    11281 attcgttgtt gaatgtaaca aagaaaatat tgatgctgtt gtggttgcga cagtgacgga
    11341 aaaaccaaat ctagtcatgc actggaatgg tgaaacaatt gtcgacttag aacgtcgttt
    11401 ccttgatacc aatggtgtgc gcgtggtcgt tgatgcaaag gtggtggaca aggatgtcaa
    11461 gcttccagaa gaacgtcaaa catctgctga cacacttgaa gcagataccc ttacggttct
    11521 atctgacctc aaccatgcga gtcaaaaagg attacagact atctttgact gctctgttgg
    11581 acgctcaacg gtcaatcacc cacttggtgg tcgtcaccaa ctcacaccaa ctgaggcatc
    11641 tgtgcagaaa ttaccagttc aacacggtgt gactcatact gcgtcagtca tggctcaagg
    11701 attcaaccca tatgtagctg aatggtctcc ataccacggt gctgcctatg cggtgattga
    11761 agcaactgct cgtttggttg ctgctggtgc caactggtct aaggctcgct tctcttacca
    11821 agagtacttc gagcgcatgg acaaacaagc tgagcgtttt ggtcagccag tagcagctct
    11881 cctaggctct atcgaagctc agattcagct tggtttgcca tctatcggtg gtaaggattc
    11941 tatgtctggt acttttgaag aattgacagt gccaccaacc ttggtcgctt ttggggtgac
    12001 gacagcggat agccgtaagg tgctttcgcc agagttcaag aatgctggtg aaaacatcta
    12061 ctacatccca ggccaagccc tctcagcaga gattgatttt gacttgatta agtctaactt
    12121 tgctcagttt gaagcccttc aaaaggctca caaa
//
