LOCUS       NZ_JALMDK010000021     22559 bp    DNA     linear   CON 13-SEP-2024
DEFINITION  Crossiella sp. S99.2 NODE_21_length_125966_cov_188.256091, whole
            genome shotgun sequence.
ACCESSION   NZ_JALMDK010000021
VERSION     NZ_JALMDK010000021.1
KEYWORDS    WGS; RefSeq.
SOURCE      Crossiella sp. S99.2
  ORGANISM  Crossiella sp. S99.2
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Crossiella.
REFERENCE   1  (bases 1 to 125966)
  AUTHORS   Gonzalez-Pimentel,J.L.
  TITLE     From North to South: A Spanish map of bacteria producing bioactive
            compounds in show caves
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 125966)
  AUTHORS   Gonzalez-Pimentel,J.L.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-APR-2022) Agroquimica, Microbiologia Ambiental y
            Conservacion de Suelos, Instituto de Recursos Naturales y
            Agrobiologia, Av. Reina Mercedes 10, Sevilla 41012, Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2021
            Assembly Method                   :: SPAdes v. 3.14.1
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 200x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023094165.1-RS_2024_09_13
            Annotation Date                   :: 09/13/2024 06:26:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,481
            CDSs (total)                      :: 9,422
            Genes (coding)                    :: 9,365
            CDSs (with protein)               :: 9,365
            Genes (RNA)                       :: 59
            rRNAs                             :: 2, 1 (5S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 1 (5S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 8 of 57
            Pseudo Genes (incomplete)         :: 50 of 57
            Pseudo Genes (internal stop)      :: 4 of 57
            Pseudo Genes (multiple problems)  :: 4 of 57
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:32:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 93533
            Orig. end                         :: 116092
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JALMDK010000021.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22559
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-iii"
                     /region_number="1"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22559
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22559
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:12559](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12559)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    178..193
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 24.02"
                     /tool="antismash"
     misc_feature    214..229
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.27"
                     /tool="antismash"
     misc_feature    complement(215..228)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.8"
                     /tool="antismash"
     misc_feature    complement(704..713)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.9"
                     /tool="antismash"
     misc_feature    complement(768..783)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.68"
                     /tool="antismash"
     gene            complement(780..1646)
                     /gene="prmC"
                     /locus_tag="MZC64_RS44535"
                     /old_locus_tag="MZC64_44545"
     CDS             complement(780..1646)
                     /EC_number="2.1.1.297"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /GO_process="GO:0018364 - peptidyl-glutamine methylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="prmC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015104702.1"
                     /locus_tag="MZC64_RS44535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_44545"
                     /product="peptide chain release factor N(5)-glutamine
                     methyltransferase"
                     /protein_id="WP_247765543.1"
                     /transl_table=11
                     /translation="MNRQPLRLAVMDAERILTEAGVASPRVDAELLAAHVLGVERMRLG
                     LIPLVDPPVIEAFHRLVRRRASRVPLQHLLGKAWLGPLELAVGPGVFTPRPETELLLEW
                     GLNALTGVARPVVVDLCTGSGALALAVAHQRPDALVHAVERDPAALTWARRNADAQADR
                     GDTPVRLHAGDVADPGLLAELDGAVDLVLCNPPYVPEGTPVPPEVAEHDPHAAVFAADE
                     GLAVIRHVVRCAARLLKPGGALAVEHDDTQGESAVALLATRRVLAEVTGHLDLTDRPRF
                     VTARRTL"
     gene            1780..2754
                     /locus_tag="MZC64_RS44540"
                     /old_locus_tag="MZC64_44550"
     CDS             1780..2754
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MZC64_RS44540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MZC64_44550"
                     /product="hypothetical protein"
                     /protein_id="WP_247765541.1"
                     /transl_table=11
                     /translation="MRNSLALITITGALLLAGSPAQAAPVITDLGALPGYHLSWANDIG
                     PDGVVGASSTPGQVQGVFWPNDGVAVQLRPAAAGWATAEAINNSRVIVGTSGDQAVRWA
                     HPGAAPVLLPSPAVYTRTTAKSINNKGLIAGNGDHPETYQTRALRWSSGRAPRVLPPLP
                     GHQESEVGSAGAVGENSVVVGKSDDDAVFWDAAGNVHKLPQLAGWARSTAHAINRHGVI
                     VGSYDLPGGGGGAVRWERGRVTVLPNLPGADHSGAYSINDSGVSVGASSGRAVRWDAAG
                     VATELPKLSDQLPGHAKAINERGQVTGTNSPQWRQDHAVRWTP"
     gene            complement(2765..3844)
                     /gene="prfA"
                     /locus_tag="MZC64_RS44545"
                     /old_locus_tag="MZC64_44555"
     CDS             complement(2765..3844)
                     /GO_function="GO:0003747 - translation release factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006415 - translational termination
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="prfA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007023389.1"
                     /locus_tag="MZC64_RS44545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_44555"
                     /product="peptide chain release factor 1"
                     /protein_id="WP_247765540.1"
                     /transl_table=11
                     /translation="MDTASLDTLLVEYTELEGRLADPAVHADQAAARKLGRRYAELTPV
                     VRTLRELDQARSDREAALELASEDAAFAAEAAALAETIPALERKLTELLLPRDPHDAAD
                     VVMEIKSGEGGEESALFAGDLLRMYLRFAERQGWKTEVLDSVESDLGGFKDVTVVVKSK
                     GGAELDGVWARLKYEAGVHRVQRVPVTESQGRVHTSAAGVLVYPEQEDVEVEIDEKDLR
                     VDVFRSSGHGGQSVNTTDSAVRITHLPTGIVVSCQNERSQLQNKARAMAVLQNRLVALA
                     EEEAARKASADRRSQVRTVDRSERVRTYNFPENRISDHRVNYKAYNLDQVLDGELTGVL
                     DALSAADKAERLAAAGATA"
     gene            complement(3924..4136)
                     /gene="rpmE"
                     /locus_tag="MZC64_RS44550"
                     /old_locus_tag="MZC64_44560"
     CDS             complement(3924..4136)
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpmE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011875002.1"
                     /locus_tag="MZC64_RS44550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_44560"
                     /product="50S ribosomal protein L31"
                     /protein_id="WP_185009561.1"
                     /transl_table=11
                     /translation="MRSGIHPDYVVTQVNCGCGNSFQTHSTKKTGQITVEVCSNCHPFY
                     TGKQKILDTGGRVARFEARYGKRNK"
     gene            4389..4760
                     /locus_tag="MZC64_RS44555"
                     /old_locus_tag="MZC64_44565"
     CDS             4389..4760
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MZC64_RS44555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MZC64_44565"
                     /product="hypothetical protein"
                     /protein_id="WP_247765539.1"
                     /transl_table=11
                     /translation="MLTWLGIPLLVIGSMIGIGGLGLLAFGSPTQLYSATFGVAAALGL
                     VTSRNVVWQAGWQRHGLRWPYLLALVAAGVALDGQELPSWLAVTLGVPCLLLLVRTLRT
                     LPTLDADGGCAETRDLIST"
     gene            complement(4842..6104)
                     /gene="fabF"
                     /locus_tag="MZC64_RS44560"
                     /old_locus_tag="MZC64_44570"
     CDS             complement(4842..6104)
                     /EC_number="2.3.1.179"
                     /GO_function="GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (82-417). E-value:
                     5e-62. Score: 202.1. Matches aSDomain:
                     nrpspksdomains_MZC64_RS44560_PKS_KS.1"
                     /codon_start=1
                     /gene="fabF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020657369.1"
                     /locus_tag="MZC64_RS44560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_44570"
                     /product="beta-ketoacyl-ACP synthase II"
                     /protein_id="WP_247765538.1"
                     /sec_met_domain="t2fas (E-value: 2.5e-160, bitscore: 526.6,
                     seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 2.7e-49, bitscore:
                     160.9, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVAEFRKHRPRVVVTGWGAISPVGLTAEDTWSAFMAGRSGIARI
                     ATFDAEPFPSQIAGEVKGFVAEDHMPRKLSRRMDLFAQYGVAASIQAVEAAKLTIDSEL
                     APRCGVLIGTGYGAMKYMQDSVKLLTEKGGRAVGAYQAITGAHDSATGEVSLMFGAAGP
                     TLALNSACATGTDAIGTATRWIQYGEADVVIAGGAEMSVTPLDIASSSNARALSRRNDD
                     PERASRPFDADRDGFVMAAGSGVVILESLDHALRRGAPILAEIVGYASTSDAHHWTAPH
                     PEGAGARRAMTRALADAGVAPEQIDYINAHGTSTELNDKTETQAIRNVLGEHATKIPVS
                     STKSMTGHMIGAAGAIELIACGFAMRTGVVPPTINLHNPLDPEMNFVPNAPQEHQVRYA
                     MSNSFGFGGHNAVLVAKSWES"
     aSDomain        complement(4854..5858)
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MZC64_RS44560_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="5.00E-62"
                     /label="MZC64_RS44560_PKS_KS.1"
                     /locus_tag="MZC64_RS44560"
                     /protein_end="417"
                     /protein_start="82"
                     /score="202.1"
                     /tool="antismash"
                     /translation="QYGVAASIQAVEAAKLTIDSELAPRCGVLIGTGYGAMKYMQDSVK
                     LLTEKGGRAVGAYQAITGAHDSATGEVSLMFGAAGPTLALNSACATGTDAIGTATRWIQ
                     YGEADVVIAGGAEMSVTPLDIASSSNARALSRRNDDPERASRPFDADRDGFVMAAGSGV
                     VILESLDHALRRGAPILAEIVGYASTSDAHHWTAPHPEGAGARRAMTRALADAGVAPEQ
                     IDYINAHGTSTELNDKTETQAIRNVLGEHATKIPVSSTKSMTGHMIGAAGAIELIACGF
                     AMRTGVVPPTINLHNPLDPEMNFVPNAPQEHQVRYAMSNSFGFGGHNAVLVAKS"
     gene            complement(6136..8727)
                     /locus_tag="MZC64_RS44565"
                     /old_locus_tag="MZC64_44575"
     CDS             complement(6136..8727)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (4-364). E-value: 3.7e-66.
                     Score: 215.3. Matches aSDomain:
                     nrpspksdomains_MZC64_RS44565_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009945159.1"
                     /locus_tag="MZC64_RS44565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_44575"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_247765536.1"
                     /sec_met_domain="AMP-binding (E-value: 1.9e-61, bitscore:
                     200.7, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="Aldedh (E-value: 4.4e-28, bitscore: 90.8,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSTAEVEQDALRVAAALRARGLCPGNRVILKADNSAGYVTVLLA
                     LVHLDISIVLVDHRQTPEETARITAFARAGWALVRPEVSQDLTVLDADRVISLDGLLED
                     AAAIPALGGSLSFVDWFTRSDALIAWSSGTTGEPKGIVRSGKSFLGNIERTQQRMAYTE
                     ADVLMPLLPFSHQYGLSLVLLWWIARCSLIVAPYARLDHAVDMAGRYRATVVDATPATY
                     HTMLKLVERRPESAEGLRDVRMWCVGGAPLDRALAEKFVVATGQPLLDGYGSTEVGNIA
                     LAAPGNAIGCGQPLDGVVVRILDEDGNAVPPGEIGEILVSSPGQLTGYLAADGSITEHA
                     EEVYRTNDIGYTDEEGNLYVVGRKYAVHRMGHTLYPEALARKAEEAGAAVKVVALDDER
                     RGSQLVFVVADPDLREARYWREKICALLPSYEQPNQVLVVTEFPLNNNGKPDLTRLTDL
                     AAVPHPARLAALRAVAEHIRSDPQPLIDVLTEISNHKAVLDEIEAGLSALEGALEEVSA
                     YRPGRVPKMAVFMSSNVLFYSYVLYTLIPSLYTDEIIFRPSSQVTGTTKRLHELLAPVH
                     KLESIELTTLSQRQFVEVPVAEADVLVFTGAYQNAELVRAQLRDDQMLLFYGQGVNPFV
                     VAEGADIDLAVTDAVRIRMLNSGQDCFAPDVFLVHAGEAEAFVDQLTKRVGELRYGSYT
                     DPGADYGPLYYETAIEAAADYLRLNREHIVAGGRLDFRSRHLEPAVLVRPYNKKMPIEE
                     TFAPIFNVVVYQNTQQLRAFANHPTVNERAMGAMVYGDAPDVVSALGKRHYVSVNLTVL
                     DTDDGNKPFGGYGVAANYVAYQGQRVAEPLLISKAVAEHLPAARKTRMANA"
     aSDomain        complement(7636..8715)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MZC64_RS44565_AMP-binding.1"
                     /evalue="3.70E-66"
                     /label="MZC64_RS44565_AMP-binding.1"
                     /locus_tag="MZC64_RS44565"
                     /protein_end="364"
                     /protein_start="4"
                     /score="215.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="AEVEQDALRVAAALRARGLCPGNRVILKADNSAGYVTVLLALVHL
                     DISIVLVDHRQTPEETARITAFARAGWALVRPEVSQDLTVLDADRVISLDGLLEDAAAI
                     PALGGSLSFVDWFTRSDALIAWSSGTTGEPKGIVRSGKSFLGNIERTQQRMAYTEADVL
                     MPLLPFSHQYGLSLVLLWWIARCSLIVAPYARLDHAVDMAGRYRATVVDATPATYHTML
                     KLVERRPESAEGLRDVRMWCVGGAPLDRALAEKFVVATGQPLLDGYGSTEVGNIALAAP
                     GNAIGCGQPLDGVVVRILDEDGNAVPPGEIGEILVSSPGQLTGYLAADGSITEHAEEVY
                     RTNDIGYTDEEGNLYVVGRK"
     CDS_motif       complement(7735..7797)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MZC64_RS44565_0002"
                     /evalue="3.80E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="MZC64_RS44565"
                     /protein_end="331"
                     /protein_start="310"
                     /score="12.9"
                     /tool="antismash"
                     /translation="PPGEIGEILVSSPGQLTGYLA"
     CDS_motif       complement(8302..8352)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MZC64_RS44565_0001"
                     /evalue="8.30E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="MZC64_RS44565"
                     /protein_end="142"
                     /protein_start="125"
                     /score="12.4"
                     /tool="antismash"
                     /translation="ALIAWSSGTTGEPKGIV"
     misc_feature    9012..9028
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.92"
                     /tool="antismash"
     misc_feature    complement(9020..9034)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.31"
                     /tool="antismash"
     gene            complement(9888..9992)
                     /locus_tag="MZC64_RS44570"
                     /old_locus_tag="MZC64_44580"
     CDS             complement(9888..9992)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF039607.4"
                     /locus_tag="MZC64_RS44570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_44580"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_247765535.1"
                     /transl_table=11
                     /translation="MDVLDLQAIEPAEVDGPAEFGAGLISTLSLLICW"
     CDS_motif       complement(9936..9992)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MDVLDLQAIEPAEVDGPAE"
                     /locus_tag="MZC64_RS44570_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9888..9935)
                     /prepeptide="core"
                     /locus_tag="MZC64_RS44570_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="1.80"
                     /molecular_weight="1539.9"
                     /monoisotopic_mass="1538.9"
                     /core_sequence="FGAGLISTLSLLICW"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MDVLDLQAIEPAEVDGPAE"
                     /leader_location="[9935:9992](-)"
                     /alternative_weights="1557.9"
                     /alternative_weights="1575.9"
     gene            complement(10001..12559)
                     /gene="lanKC"
                     /locus_tag="MZC64_RS44575"
                     /old_locus_tag="MZC64_44585"
     CDS             complement(10001..12559)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="MZC64_RS44575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_44585"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_247765534.1"
                     /sec_met_domain="micKC (E-value: 1.5e-248, bitscore: 819.9,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.1e-10, bitscore: 34.2,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.4e-06, bitscore:
                     18.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEVEYEKYCFVDRYFYDSPAHRTAAVERYPLVSAPLPPHWRRSR
                     RESWVVLHPQGAPTPDQGWKIHVSATPDGAAEVLEIVAADCLLHRVPFKFLDSRAAVLA
                     HNAKYAARGASGKFITLYPADETQFARALHRLDPQLAGRPGPYILNDLRWGQGPLYVRY
                     GGFTERYCLTAEGELVPALADPEGNLVPDQRGPKFSPPSWVALPEVLRPHLDRRRARAG
                     LPYRVLRPLHFSNAGGVYLAEEPDGSRQLVLKEARPHAGLDVDGHDAVHRLANEHAMLT
                     LLAGLPGVPTVLGRFTCWEHEFLALSHVEGVPLATELVRRYPLAAAGADDAAVAGYTQW
                     ALDVVAKVTAAVAALHERGVVFGDLHPMNIMVGPDGRITLLDFELAAPVSAATRAPLGA
                     PGYTAPPGVGGFDVDHYALAALRLALFLPLNSLCALAPGKVRSLCAAVLARFPLPPEYV
                     RPILARLCAGAGSPPPSTRDPVPPAFATGPADLARLRERITAAIVAAATPQRSDRLFPG
                     DIAQFAEDGLGLAHGAAGVLYALHTSGSGRFPEYEDWLLRALARRGAGRPGLFAGGHGI
                     ALVLAEFGHVETAREVLERLAAATEACTGADLYEGLSGIGLTLLHLGRVIGRSWLTEWG
                     LDLADRVAALVLAGVEAVPFGLPGLTRGGAGAALFLSRAHAEGGADHLLDAAGRALHRD
                     LQHAELTAAGALQVRAGRRLLPYLAAGTAGIALAMAELLRLRPDPVFTGALPAVQRALE
                     AEFTIHSGLFTGRAGLVCALAALRGLPGVDGDRVQDTLRGHVSRLAWHAVPHGGGLAFP
                     GDALLRLSHDLATGSAGVLLALHAVTTGALPLFARAHEGR"
     misc_feature    12571..12586
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.35"
                     /tool="antismash"
     misc_feature    12576..12590
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.93"
                     /tool="antismash"
     misc_feature    12630..12644
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.96"
                     /tool="antismash"
     gene            complement(12719..13396)
                     /locus_tag="MZC64_RS44580"
                     /old_locus_tag="MZC64_44590"
     CDS             complement(12719..13396)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009943835.1"
                     /locus_tag="MZC64_RS44580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_44590"
                     /product="response regulator transcription factor"
                     /protein_id="WP_247765527.1"
                     /transl_table=11
                     /translation="MTIRLLLVDDDAVVRAGLSTLLSLRPDLEVVGEAATGVAALAKAA
                     ELCPDVVLMDVRMPELDGIGATRRLIGEWTGPAPRPRVLMLTTFDSDFHVYSALAAGAS
                     GFLRKDTSPEELAHAVRVVSRGDAMLSPAVTLRLIEHTVHRMVQPDPAVARGIGLLGER
                     EIDVVKLVATGWSNAAIAEKLESTESSVKSRVTRVLAKLGLDNRVQLAIFAYRTGLVSI
                     SPE"
     gene            complement(13393..14520)
                     /locus_tag="MZC64_RS44585"
                     /old_locus_tag="MZC64_44595"
     CDS             complement(13393..14520)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019350.5"
                     /locus_tag="MZC64_RS44585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_44595"
                     /product="histidine kinase"
                     /protein_id="WP_247797793.1"
                     /transl_table=11
                     /translation="MLLVGALGALDLLALFLVPAEPWRLAAGALAAYGVTLPLLLRRRR
                     PVVIFLIVGAMVLVRGVLGVPEMTGGIPLLIAAHALGRYGARRHRPWVAWVVAGWGGAH
                     AVIVSLMYEKHIQLADWLVVALAVGLAYMIGSHQHRFAAHVGSLRRSVHRQRERRSREV
                     RSAVGAERERIALDLHDVVGNHLSALSVQTHVFEELLARHDPQAVLAANQIRESSRQAM
                     TEMVRLQNLLRGIADGPDGADCGPEGVTRLASAVRNAGNDVEFSVAELPRSMSPEVGAE
                     GFLVLQEALTNVVKHASPTRVSIEVGVDTATDALRLRVVNEPPRAARLPAVPGSGLGLL
                     SMQARVARLGGQLSSAAAPDGGYVVDARIPLRSVS"
     gene            complement(14951..17023)
                     /gene="rho"
                     /locus_tag="MZC64_RS44590"
                     /old_locus_tag="MZC64_44600"
     CDS             complement(14951..17023)
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008186 - ATP-dependent activity, acting
                     on RNA [Evidence IEA]"
                     /GO_process="GO:0006353 - DNA-templated transcription
                     termination [Evidence IEA]"
                     /codon_start=1
                     /gene="rho"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018685649.1"
                     /locus_tag="MZC64_RS44590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_44600"
                     /product="transcription termination factor Rho"
                     /protein_id="WP_247765524.1"
                     /transl_table=11
                     /translation="MSETELLGGDAVETTAASPSANGTATRRRGGLSGMVLAELRQLAG
                     ELGIGNTSGMRKGDLIAAIKERQGGGSAPRAEAAKPAKAETGQLALGAESTPAPKATAV
                     ESAPPAPAATPAAADNAAGEGDAGGDNARRNRRRRAATRPAGSPEGEQRNPRERAPEQP
                     QADKPVEQVEQPVAVAAEQREKPAEQRQERAERGERQERGERGDRGERGDRGNRNDRNR
                     NRNDRNDRNDRGDRGERAAAAQSQPQGVEDDEDEDGRGRRGRRFRDRRRNRGRDGEGGG
                     TDRGDRGDRGDRGERGGRGGGGGDTEVREDDVLLPVAGILDVLDNYAFVRTSGYLAGPN
                     DVYVSLSLVRRYGLRRGDAITGAVRQPRDGEAQRQKFNPLVRVDSINGLEPEAVRGRPE
                     FTKLTPLYPNERLRLETEPHILTTRVIDLVMPIGKGQRALIVSPPKAGKTSVLQAIANA
                     ITTNNPECHLMVVLVDERPEEVTDMQRSVKGEVIASTFDRPPGDHTTVAELSIERAKRL
                     VEMGHDVVVLLDSITRLGRAYNLAAPASGRILSGGVDSTALYPPKRFLGAARNIEGGGS
                     LTIFATALVETGSTMDTVIFEEFKGTGNAELKLDRKIADKRTFPAVDVDASGTRKEELL
                     LSPDELAVTIKLRRVLAALDDQQAIDLLLDRLRKTRTNIEFLMTVSKNTPGSNDD"
     gene            complement(17345..18274)
                     /gene="thrB"
                     /locus_tag="MZC64_RS44595"
                     /old_locus_tag="MZC64_44605"
     CDS             complement(17345..18274)
                     /EC_number="2.7.1.39"
                     /GO_function="GO:0004413 - homoserine kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0009088 - threonine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009948458.1"
                     /locus_tag="MZC64_RS44595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_44605"
                     /product="homoserine kinase"
                     /protein_id="WP_247765520.1"
                     /transl_table=11
                     /translation="MLVRIGSGVRVTVPASTANLGSGFDSLGLALGLYDEVEVRVAPAG
                     EIRVRVEGQGAGRVPTDERHLVVRAVRSALSSCGVAGLGLDLVCRNRIPHARGLGSSAA
                     AAVAGVAAGFALADRELDDGVLQLAAEFEGHADNAAASVYGGIVIAWQDGKDYQAIRLE
                     PHEELAPLVFVPETESETKTTRGLLPEQVPLRDAAFAAGRSALAVYALTTDPWLLLPGT
                     ADRLHQEYRRPAFPATMALVDSLRAAGIPAMVSGAGPTVIAFPRGGHLPDEADLSGFTP
                     MALPIDQGGVVVEPIGGSANPSEGAKPR"
     gene            complement(18283..18852)
                     /locus_tag="MZC64_RS44600"
                     /old_locus_tag="MZC64_44610"
     CDS             complement(18283..18852)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MZC64_RS44600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MZC64_44610"
                     /product="hypothetical protein"
                     /protein_id="WP_247765517.1"
                     /transl_table=11
                     /translation="MPFVGRDQHSQFPVPPGSSGLPRWQLVPGAARSRRAWAVNGVVQT
                     GGAVFFLGLWCFLMAQLNRANLEFFVVLLGQLPLYALGFGWTAAFLWQGRALFYGELVD
                     VAALPGWRRTAVIGSLIILSCGVLITTISILLPWMLGRHGLPGLVWFQVFGVLPVCLFG
                     DVPRSVVQSLDKRVREVARTGWARMP"
     gene            complement(18957..19742)
                     /locus_tag="MZC64_RS44605"
                     /old_locus_tag="MZC64_44615"
     CDS             complement(18957..19742)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025377.5"
                     /locus_tag="MZC64_RS44605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_44615"
                     /product="ESX secretion-associated protein EspG"
                     /protein_id="WP_247765515.1"
                     /transl_table=11
                     /translation="MTVSLDLELNALEFEVLWEHLQLGDKPTELNTLSHGVTDEERAHF
                     RRRAWDSLEQRGRAEDGRLDVELEDLLVLLARPNRSIDIRFSWRVGEQILPEIKAICSA
                     VGDTGVLAVHDGDRYRFGWVRSTGLAPAAAGLLPQPPPGRIGSVTVAADVLESAVSQAA
                     EAGKVFVQILTSRGVRQEDAQLLWEIGDADRTLYAQFGATARDQYGRSVRASSVLNVFD
                     IQAGRCGSRERNGWINFFGVDNRKVIEQLDSLLGEVVEH"
     gene            complement(19739..20950)
                     /locus_tag="MZC64_RS44610"
                     /old_locus_tag="MZC64_44620"
     CDS             complement(19739..20950)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013021.5"
                     /locus_tag="MZC64_RS44610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_44620"
                     /product="PPE domain-containing protein"
                     /protein_id="WP_247765514.1"
                     /transl_table=11
                     /translation="MTNWDAYSHEQIHKMINEGRGHYALSSRDLLWEKQAERLSRIGDN
                     VKKAFEAATGVMQGKSFDQMQERVSPAHQWATQASTMAGTMRSTSQTSTNTFVDTQKKI
                     EPPKQVTSSDNVISRGWASLTGGMTDRQQEQQNKDNAERQARETMRGYETTVLSSTTNL
                     PTFIAPDPIDVGVTSSGGGTTEIGGTTGTPTRRGSTGNNNTTRDRGGVGDRDGDGIPDD
                     RDPVDDRDPVDDRNPGRDKDGDGIPDDRDPVDNRFPIELPNDQVDPNRVTPTPVLNQPL
                     PSNPVPVGPGGGPSPFGGGGMPMGGMPGGFGANAAGMRPGFGPGGMGGVGAGGLGGPGG
                     AGGFGPGGRGGAGGMGGPMGGGARANGEEDKEHQRPDYLIETDDIFGDGMLVAPPVIGE
                     NPGL"
     gene            complement(20980..21294)
                     /locus_tag="MZC64_RS44615"
                     /old_locus_tag="MZC64_44625"
     CDS             complement(20980..21294)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MZC64_RS44615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MZC64_44625"
                     /product="hypothetical protein"
                     /protein_id="WP_247765513.1"
                     /transl_table=11
                     /translation="MADRVMIKPDQVPGLIAKLEAELLEAKDLKEYTSAIGTQEAPAKD
                     PASVELAKRLDVPATGPAGLVAAADKLIASLEAMITNLKNGLADYERQEQANRSTMKRA
                     "
     misc_feature    complement(21374..21389)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     gene            complement(21412..21999)
                     /locus_tag="MZC64_RS44620"
                     /old_locus_tag="MZC64_44630"
     CDS             complement(21412..21999)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023502.5"
                     /locus_tag="MZC64_RS44620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_44630"
                     /product="DUF3558 domain-containing protein"
                     /protein_id="WP_247765511.1"
                     /transl_table=11
                     /translation="MTVRRWLLGSMLMSAAVLVTACGGGATPTPPGTQAATSSAAAPGE
                     WTKVTAQPKTVEGAFRTTPCAALTPAQLTEFKLPDKPKAATASCTWTNYENSRASVEVE
                     LYNSTLLQKFGLDAPKPESGLVVAKVAGYPAVRSVEGKDQRGCMVFVAISAKETLRSYF
                     SSYRSMPEVTQDACGLAEQVLTAVIEKLPAAA"
ORIGIN
        1 tggatcagcc ggtaggtgcg cggattgtgc atcagcatcg ccagcacgca gccgagcagg
       61 atcgagacgt agtgcaccgg ccagccggag gcgtgcgggc cgaaggtgaa cggggtggcc
      121 accagcgcgc cgacgatcag cagtccggtg atgcccaggc ggcggcgcag cggcagcacg
      181 ccgaaggcga acgcgaccag cggccagacc aggtagaact tctgctcgat gcccagcgac
      241 caggactggc cgaacgggtt ggagccggcg aactcgttga agaaggtcag gtacagcggc
      301 atcgcctcgc ccaggtggct gctctggtag atgcccagga ccagggtggc caccgcgagg
      361 aaggccagca ccacgaagta gaccggcagg atgcggaaga cccggcgcag gtagaacgcc
      421 ttgagcgcga cccggccggt gcgggcctcc tcacgcagca tcagcgtggt gatcaggtac
      481 ccggagagca cgaagaagac ctgcacaccg atccagccct ggagccggtc cggaccgccg
      541 tagtggaaga ccacgaccat gaccgcggcg atggcgcgca gtccgtccag gccgtcgaac
      601 cggcgcatgg ccatgtaccc ggcgtgcgtt agtgacttca ttcagcttgc tccccgacgt
      661 tggtgccttc ggagagcaag ttgcccgaac gggctacgga gttgcaaaaa acggcgaaaa
      721 gtgacgacga tcacgaccgg atgcgcgggt caacttaggc catttggggc aaacaaccct
      781 caaagtgtcc ttcgcgcggt gacaaatcgt ggacgatcgg tgaggtccag gtgaccggtc
      841 acctcggcca gcacccggcg ggtggccagc agcgccaccg cggattcgcc ctgggtgtcg
      901 tcgtgttcca ccgccagcgc gccgccgggc ttgagcagcc gggccgcgca gcgcaccacg
      961 tgccggatca ccgccagccc ctcgtccgcg gcgaagaccg cggcgtgcgg gtcgtgctcg
     1021 gccacctccg gcggcaccgg ggtgccctcc ggcacgtacg gcgggttgca cagcaccagg
     1081 tccaccgccc cgtccagctc ggccagcagc ccgggatcgg ccacatcgcc tgcgtgcagc
     1141 cggaccgggg tgtcgccccg gtcggcctgg gcgtcggcgt tgcgccgggc ccaggtcagc
     1201 gcggccggat cgcgttccac cgcgtgcacc agcgcgtccg gccgctggtg cgccacggcc
     1261 agcgccagcg cgccagagcc ggtgcacagg tccaccacca ccggccgcgc cacgccggtc
     1321 agcgcgttca ggccccactc cagcagcagt tcggtctccg gccgcggggt gaacaccccc
     1381 ggccccaccg ccagctccag cgggcccagc caggccttgc cgagcaggtg ctgcaacggc
     1441 acccggctcg cccgccgccg caccagccgg tggaacgcct cgatcaccgg cgggtccacc
     1501 agtgggatga ggcccagcct catccgctcc acgccgagca cgtgcgcggc gagcagttcg
     1561 gcgtccaccc gggggctggc caccccggcc tcggtcagga tccgctcggc gtccatgacc
     1621 gcgagacgca acggctgtcg gttcacaacg cgcgaggtta ccgactaccc ggtatcactc
     1681 gattgatcga cgcgttgcgc cgatcagcag tcagtccccc ggaggaccgc tcactagctt
     1741 cagcaccggt tcattcgttc cggggagggg acatcgaacg tgcgtaattc actcgcgctc
     1801 atcacgatca ccggggccct gctgctggct ggttcacccg cccaggccgc gcccgtcatc
     1861 accgacctgg gcgcgttgcc cgggtatcac ctgtcctggg ccaacgatat cggcccggac
     1921 ggcgtggtcg gggcgtccag cacgcccggc caggtccagg gggtgttctg gcccaacgac
     1981 ggcgtcgcgg tgcagctgcg gcctgccgcc gccggctggg cgaccgccga ggcgatcaac
     2041 aacagccggg tcatcgtcgg cacctccggc gaccaggcgg tgcgctgggc ccatcccggc
     2101 gccgcgccgg tcctgctgcc cagcccggcg gtctacacca ggaccaccgc gaaatcgatc
     2161 aacaacaagg gcctgatcgc gggcaacggc gatcacccgg agacctacca gaccagggcc
     2221 ctgcgctgga gttccggccg ggcgcccagg gtgctgccgc cgctgcccgg ccaccaggag
     2281 agcgaggtcg gctccgcggg cgcggtcggg gagaactccg tcgtggtcgg caaatccgac
     2341 gacgacgcgg tgttctggga cgccgccggg aacgtgcaca agctgcccca gctggccggc
     2401 tgggcccgca gcacggcgca cgcgatcaac cggcacgggg tgatcgtcgg ctcctacgac
     2461 ctgcccggtg gcgggggcgg ggcggtgcgc tgggaacgtg gccgggtcac cgtgctgccg
     2521 aacctgcccg gcgccgacca cagcggcgcc tactcgatca acgactcggg cgtgtcggtc
     2581 ggcgcctcca gcgggcgcgc ggtccgctgg gacgccgcgg gcgtggcgac cgagctgccc
     2641 aagctgagtg atcagctgcc agggcacgcc aaggcgatca acgagcgtgg ccaggtcacc
     2701 gggacgaaca gcccgcagtg gcggcaggac cacgcggtgc gctggacgcc ctgaccggta
     2761 agcgtcaggc agtcgctccg gccgcggcga ggcgttccgc cttgtccgcg gccgagagcg
     2821 cgtccagcac gccggtcagc tcgccgtcga gcacctggtc caggttgtat gccttgtagt
     2881 tgacccggtg gtcggagatc cggttctccg ggaagttgta ggtgcgcacc cgctcggagc
     2941 ggtccaccgt gcggacctgg ctgcgccggt ccgccgaggc cttgcgggcg gcctcctcct
     3001 cggccagcgc gaccagccgg ttctgcagca cggccatcgc gcgggccttg ttctgcagct
     3061 ggctgcgctc gttctggcag gagaccacga tgccggtggg caggtgggtg atgcgcaccg
     3121 cggagtcggt ggtgttcacg ctctggccgc cgtggccgga ggagcggaag acgtccaccc
     3181 gcaggtcctt ctcgtcgatc tcgacctcga cgtcctcctg ctcggggtag accagcaccc
     3241 cggccgcgga ggtgtgcacg cggccctggg actcggtcac cggcacccgc tgcacccggt
     3301 gcacgccggc ctcgtacttc agccgggccc acaccccgtc cagctcggcc ccgcccttgc
     3361 tcttgaccac cacggtgacg tccttgaacc cgcccaggtc ggactccacc gagtcgagca
     3421 cctcggtctt ccagccctgc cgctcggcga agcgcaggta catccgcagc aggtccccgg
     3481 cgaacagcgc cgactcctcg ccgccctcgc cggacttgat ctccatgacc acgtccgcgg
     3541 cgtcgtgcgg gtccctgggc agcagcagct cggtgagctt gcgctccagc gccgggatgg
     3601 tctcggccag cgcggcggcc tcggcggcga aggccgcgtc ctcactggcc agctccagcg
     3661 cggcctcccg gtcggaccgg gcctggtcca gctcgcgcag ggtgcgcacc accggggtca
     3721 gctcggcgta gcggcggccc agcttgcgcg ccgcggcctg gtcggcgtgc accgcgggat
     3781 cggccagccg accctccagc tcggtgtact ccacgagcag ggtgtccagc gaggcggtgt
     3841 ccacggcgtc ctcttcccgg taagaccttc aggccgacac gacaacggcg cccaccccag
     3901 cgggatgggc gccgtgaagt cggctacttg ttgcgcttgc cgtagcgggc ctcgaagcgc
     3961 gccacgcggc caccggtgtc gaggatcttc tgcttgcccg tgtagaaggg gtggcagttg
     4021 gagcagacct cgaccgtgat ctggccggtc ttcttggtgc tgtgggtctg gaaagagttg
     4081 ccacagccgc agttcacctg ggtgaccacg tagtcggggt ggataccgct tctcaccgtc
     4141 ttgttccttt ctcaggggcc gccgggtccc cacgagccgt acaacggggt gaaccggagc
     4201 cttattccga cccctgagta tgccaggtct tcggcggtgc tctcgccgtg ggaccgctca
     4261 ccttcagaaa ccgacctccg ggcgcaatgg ccggaccatc gggcgcattg ccagcgcaga
     4321 ctgctgatat cggtcacagg ccgcagcaaa atcatcacgt gctgtgtgcg gcgagctggc
     4381 gagtacccat gctgacctgg ctgggcatcc cgctgctggt catcggatcg atgatcggca
     4441 tcggtggtct cggcctgctg gccttcggct cccccaccca gctctacagc gcgaccttcg
     4501 gcgtcgccgc cgcactcggc ctggtcacca gccgcaacgt ggtctggcag gccggctggc
     4561 agcggcacgg cctgcgctgg ccctacctgc tggcactggt ggccgccggg gtcgccctgg
     4621 acggtcagga gctgccttcc tggctcgcgg tcaccctcgg cgtgccctgc ctgctgctgc
     4681 tcgtgcgcac gctgcgcaca ttgcccaccc tggacgccga tggcggctgc gccgagacca
     4741 gggatctgat cagcacctga tgagcccgct cccctgctga aacggaaacg gcgcgtcccc
     4801 cgcaggcccg gggacgcgcc gtttccgtgt gcctgagggg ctcagctctc ccagctcttg
     4861 gcgaccagca ccgcgttgtg cccgccgaag ccgaaggagt tgctcatcgc gtaccgcacc
     4921 tggtgctcct gcggcgcgtt gggcacgaag ttcatctccg ggtccaacgg gttgtgcagg
     4981 ttgatcgtgg gcggcaccac gccggtgcgc atggcgaaac cacaggcgat cagttcgatc
     5041 gcgcctgccg cgccgatcat gtgcccggtc atcgacttgg tggagctgac cgggatcttg
     5101 gtggcgtgct cgcccagcac gttgcggatg gcctgggtct cggtcttgtc gttcagctcg
     5161 gtgctggtgc cgtgcgcgtt gatgtagtcg atctgctccg gcgccacccc ggcgtcggcc
     5221 agcgccctgg tcatcgcccg ccgcgcgccc gcgccctccg ggtgcggggc ggtccagtgg
     5281 tgcgcgtccg aggtcgaggc gtaccccacg atctcggcca ggatcggcgc gccccggcgc
     5341 agcgcgtgat ccagcgattc caggatgacc acgccggaac cggcggccat cacaaagccg
     5401 tcccggtccg cgtcgaaggg cctgctggcc cgctccgggt cgtcgttgcg ccgggacagc
     5461 gccctggcgt tggagctgga ggcgatgtcc agcggggtga cgctcatctc cgcgccgccg
     5521 gcgatgacca catcggcctc gccgtactgg atccagcggg tggcggtgcc gatcgcgtcg
     5581 gtgccggtgg cacaggccga gttgagcgcc agggtcggtc cggccgcgcc gaacatcagg
     5641 ctgacctcgc cggtggccga atcgtgcgcg ccggtgatgg cctggtaggc cccgaccgcg
     5701 cgaccgccct tctcggtgag cagcttgacc gagtcctgca tgtacttcat cgcgccgtag
     5761 ccggtgccga tgagcacacc gcagcgcggg gccagctcgc tgtcgatggt cagcttggcg
     5821 gcctcgaccg cctggatcga ggcggccacc ccgtactggg cgaagaggtc catccgcctg
     5881 ctgagcttgc gcggcatgtg gtcctcggcc acgaatccct tgacctcgcc cgcgatctgg
     5941 gacgggaagg gctcggcgtc gaaggtggcg atccgggcga tcccgctgcg cccggccatg
     6001 aacgcggacc aggtgtcctc cgcggtcagg ccgaccgggc tgatcgcacc ccagccggtc
     6061 accaccaccc gcggccggtg cttccggaac tctgctaccg acattggctt ttctccacct
     6121 cgtatgtccg gacggtcagg cgttggccat gcgggtcttg cgggccgcgg gcaggtgttc
     6181 ggcgacggcc ttggagatca gcagcggctc ggccacccgc tgtccctgat acgccacgta
     6241 gttggcggcc acgccgtacc caccgaacgg cttgttgccg tcgtcggtgt ccagcacggt
     6301 gaggttcacc gacacgtagt gccgcttgcc cagcgcggac acgacatccg gcgcgtcgcc
     6361 gtagaccatc gcgcccatcg cccgctcgtt caccgtgggg tggttggcga aggcccgcag
     6421 ctgctgggtg ttctggtaga cgaccacgtt gaagatcggc gcgaacgtct cctcgatggg
     6481 catcttcttg ttgtagggcc gcaccagcac cgcgggctcc aggtgccggg agcggaagtc
     6541 cagccgcccg ccggccacga tgtgctcgcg gttgagccgc aggtagtccg cggccgcctc
     6601 gatcgcggtc tcgtagtaca gcgggccgta gtccgcgccg gggtcggtgt agctgccgta
     6661 gcgcagttcg ccgacccgct tggtgagctg gtccacgaac gcctcggcct caccggcgtg
     6721 caccaggaag acgtccgggg cgaagcagtc ctggccggag ttgagcatcc ggatccgcac
     6781 cgcgtcggtg accgcgaggt cgatgtccgc gccctcggcc accacaaacg ggttcacgcc
     6841 ctggccgtag aacagcagca tctggtcatc gcgcagctgg gcccggacca gttcggcgtt
     6901 ctggtaggcg ccggtgaaca ccagcacgtc cgcctcggcc accgggacct cgacgaactg
     6961 ccgctggctc aacgtggtca gctcgatgga ctccagcttg tgcaccggcg cgagcagctc
     7021 gtgcagccgc ttggtggtgc cggtgacctg gctggacggc cggaagatga tctcgtcggt
     7081 gtagagcgac gggatcagcg tgtagagcac gtaggagtag aacaacacgt tggaggacat
     7141 gaacacggcc atcttcggca cccggccggg ccggtaggcc gagacctctt cgagggcccc
     7201 ttccagcgcg ctgagtccgg cctcgatctc gtccagcacg gccttgtggt tggagatctc
     7261 ggtcagcacg tcgatcagcg gctgcggatc gctgcggatg tgctcggcca ccgcgcgcag
     7321 ggcggccagt cgcgccgggt gcggcaccgc ggccaggtcg gtgagccggg tcaggtcggg
     7381 ctttccgttg ttgttcaacg ggaactcggt caccaccagc acctggttgg gctgctcgta
     7441 ggagggcagc agcgcacaga tcttctcccg ccagtaccgg gcctcgcgca ggtcggggtc
     7501 ggccaccacg aacaccagct gactgccgcg gcgctcgtcg tccagggcga ccaccttgac
     7561 cgccgccccg gcctcctcgg ccttgcgcgc caaggcttcc gggtagagcg tgtggcccat
     7621 ccggtgcacc gcgtacttgc ggccgaccac gtagaggttg ccctcctcgt cggtgtagcc
     7681 gatgtcgttg gtgcggtaga cctcctcggc gtgctcggtg atcgagccgt ccgcggccag
     7741 gtagccggtg agctgaccgg gcgagctgac caggatctcg ccgatctcgc ccggcgggac
     7801 cgcgttgccg tcctcgtcca ggatccgcac cacgaccccg tccagcggct ggccacagcc
     7861 gatcgcgttg ccgggcgccg cgagggcgat gttgccgacc tcggtgctgc cgtagccgtc
     7921 cagcaggggc tggccggtgg ccaccacgaa cttctcggcc agcgcccggt ccagcggcgc
     7981 gccgcccaca caccacatgc gcacgtcgcg caggccctcg gcggattccg gccggcgttc
     8041 caccagcttg agcatggtgt ggtaggtcgc gggagtcgcg tccaccacgg tcgcccggta
     8101 ccggccggcc atgtccaccg cgtggtccag ccgggcgtac ggcgccacga tcagcgagca
     8161 gcgcgcgatc caccacagca gcaccaggga gagcccgtac tggtgggaga agggcagcag
     8221 cggcatcagc acgtcggcct cggtgtaggc catccgctgc tgggtgcgtt cgatgttgcc
     8281 caggaaggac ttgcccgagc gcacgatgcc cttgggttcg ccggtggtgc cggaggacca
     8341 ggcgatcagc gcgtcggagc gggtgaacca gtccacgaag gacagggagc cgcccagggc
     8401 cggaatggcc gcggcgtcct ccagcaggcc gtccaggctg atcacccggt cggcgtcgag
     8461 cacggtcagg tcctggctga cctccgggcg caccagcgcc cagcccgccc tggcgaaggc
     8521 ggtgatccgc gccgtctcct cgggggtctg ccggtggtcc accagcacga tcgagatgtc
     8581 cagatgcacc aaggccaaga gcacggtgac gtatccagcc gagttgtccg ccttgaggat
     8641 cacccggttc cctggacaca gcccgcgagc gcgcagtgcg gccgccaccc gcagtgcgtc
     8701 ctgctcgacc tcagccgtgg atcgcacgga gttcgctgtc accaacctgg ctgccacagg
     8761 ttccaccgct ggtctcccac ccctcgcccg gattcacccc gccgatggcc atgcccacag
     8821 ctcgcggcga gcgcacgcga ttgccatccg gggtttagct gccctacttg tgctcacttt
     8881 gtgtgtcgga ccactgacgg tgggttcaca cccgggtcag tcgcccctgt gcctcgtggc
     8941 ccgccaccgg ccacggttcc gttccgccaa ttccagtatt ggtcggaaca cccactcaaa
     9001 ttaccggggc gtagtcatgt ttcgacaatg agaactttct gacgttcttc cggctagata
     9061 aaacttcctg aagcaggtct ccagctgcgt ccggccgggg gctgcgttcg agcggcacgc
     9121 gaggtaccac ccgatctacg caacgacccc agtatgcctg accggtcccg gcacaccctg
     9181 gctgatctgc cgcgatcagg aggatttcca cccacccggc cgcccgatca ggctggtcgg
     9241 ggccgcgtgg accgagtcac gccgcctagt cccgatcacc cgcgagctag cccgaacagg
     9301 ctatcaatcg caccgccgaa cggctgagca cggactgttc gcgcgtccgg gagagcgggc
     9361 aaaggggccg gttgacacag agcgcgccaa ctccggcaaa ccattccctc agtcttgcga
     9421 cctacgtgaa gttattatcg aacagtcgac cgaattaacc tgttacgagg gaaaagacgt
     9481 caagccaacg caaagtgcga cggtgaataa ccgaccgcgt tctggaagaa ccacagaggt
     9541 gccagtggcc ggaagcgcgc ccgcaccgcc gcgccgccgg gtgcaccccg ccccgcgtgg
     9601 taccggtctc acgcgtccga cctgcggcga agccgggtcc gggggacggg ggccggggtg
     9661 accccgggca cagcacgtgc gggcccggaa gtccagcggc agcgcgatcc gggatcagcg
     9721 aactgagagt ccccgaggcg ggctgcgggc accgcacaag ccgctcgaag cggagcaggg
     9781 ggcaacagga tgtcgatgcc agcggggtgc acccccggaa taaggtcggg ggatgctccc
     9841 ggtcgcggcg agagcatccc ccgatggcac acagggtgtg cggtgtgtca ccagcagatc
     9901 agcagactca gcgtgctgat caggcccgcg ccgaactcgg cggggccgtc gacctcggca
     9961 ggctcgatcg cctgcaggtc cagtacgtcc atccgggttg tcacctcccc tcgtgcgctc
    10021 gggcgaacag cggcaacgcc ccggtggtca cggcgtgcag cgcgagcagc acgcctgccg
    10081 aaccggtggc gagatcgtgg gacagccgca gcagcgcgtc accggggaag gccagcccgc
    10141 ccccgtgcgg caccgcgtgc caggccagcc tgctgacgtg accgcgcagc gtgtcctgca
    10201 cccggtcacc gtccacccca ggcaggccgc ggagcgcggc gagcgcgcac accagtccgg
    10261 cccggccggt gaatagtccg ctgtgaatgg tgaactctgc ttccagtgcc cgctgcacag
    10321 cgggcagcgc cccggtgaac accgggtccg gccgcagccg cagcagttcg gccatggcca
    10381 gggcgatccc ggcggtgccc gcggccaggt agggcagcag ccggcgaccg gcgcggacct
    10441 gcaaggcccc ggccgcggtc agctcggcgt gctgaagatc ccggtgcagg gcccggccgg
    10501 ccgcgtccag caggtggtcc gcgccgccct cggcgtgcgc gcggctgagg aacagggccg
    10561 cgcccgcgcc gccgcgggtg agtccgggca gtccgaaggg caccgcctcc accccggcca
    10621 gcaccagggc ggccacccgg tcggccaggt ccaggcccca ttcggtgagc cagctgcggc
    10681 cgatcacccg gcccaggtgc agcagggtca gcccgatgcc ggagagaccc tcgtacagat
    10741 cggcgcccgt gcacgcctcg gtggccgcgg ccagccgctc caggacttcc cgcgcggtct
    10801 cgacatgccc gaactcggcc agcaccagcg cgatgccgtg cccgcccgcg aacagccccg
    10861 gccgcccggc gccgcgccgg gccagcgccc gcagcagcca gtcctcgtac tccgggaacc
    10921 ggccggatcc gctggtgtgc aaggcgtaga gcacgccggc cgcaccgtgt gccaggccga
    10981 ggccgtcctc ggcgaactgg gcgatgtcgc cggggaagag ccggtcggac cgctgcgggg
    11041 tggccgcggc cacgatcgcc gcggtgatcc gctcgcgcag ccgggccagg tcggccgggc
    11101 cggtggcgaa ggcgggcggc accgggtccc gggtgctggg tggcggggac ccggcgccgg
    11161 cacagagtcg cgccaggatc ggccgcacgt actccggcgg cagcgggaac cgggccagca
    11221 ccgcggcgca gagcgagcgg accttgccgg gggccaaggc gcacaaggag ttcagcggca
    11281 ggaacagcgc gaggcggagc gcggccagcg cgtagtggtc cacgtcgaaa ccgcccaccc
    11341 ccggcggggc ggtgtagccg ggcgcgccca gcggggcgcg ggtggccgcc gagaccgggg
    11401 cggccagctc gaagtccagc agggtgatcc ggccgtccgg gccgaccatg atgttcatcg
    11461 ggtgcagatc gccgaagacc acgccgcgct cgtgcagcgc ggccactgcc gcggtcacct
    11521 tggccaccac gtccagcgcc cactgggtgt acccggccac ggcggcgtca tcggccccgg
    11581 cggcggccag cgggtagcgg cggaccagtt cggtggccag cggcacgccc tcgacgtggc
    11641 tgagcgcgag gaactcgtgc tcccagcagg tgaagcggcc cagcaccgtg ggcacccccg
    11701 gcaatccggc cagcagggtg agcatggcgt gctcgttggc cagccggtgc accgcgtcgt
    11761 gcccgtccac gtccagcccg gcgtgcgggc gggcctcctt gagcaccagc tgccgcgagc
    11821 cgtccggctc ctcggccagg tagaccccgc ccgcgttgga gaagtgcagt gggcgcagca
    11881 cccggtaggg cagtccggcc cgcgcgcggc ggcggtccag gtgcggtcgc agcacctcgg
    11941 gcagggccac ccaggacggc gggctgaact tcgggccgcg ctgatccggc accaggttgc
    12001 cctcgggatc ggccagcgcc ggcaccagtt cgccctcggc ggtgaggcag tagcgctcgg
    12061 tgaaaccgcc gtagcgcacg tagagcgggc cctggcccca gcgcaggtcg ttgaggatgt
    12121 acggaccggg tctgccggcc agttgcgggt cgagccggtg cagcgccctg gcgaactggg
    12181 tctcgtcggc cgggtagagg gtgatgaact tgccgctggc gccgcgggcg gcgtacttgg
    12241 cgttgtgcgc gagcaccgcg gcccggctgt ccaggaactt gaacggcacc cggtgcagca
    12301 ggcagtcggc ggcgacgatc tccaggacct cggctgctcc gtcgggagtg gcggagacgt
    12361 ggatcttcca gccctggtcc ggggtgggcg cgccctgggg gtgcaggacc acccaggact
    12421 ctcgcctgct gcgccgccag tgcggcggca acggcgcgct gaccagcggg taccgctcga
    12481 ccgccgcggt gcggtgcgcc ggagagtcgt agaagtaacg atcgacgaaa caatacttct
    12541 cgtattcgac ttcaatcacg ccggcacacc tccccacttt tttgaacttt cccctcgatc
    12601 ccaaaagaac cctacccgca ccacgcattt cctcaatacg ctaagcggtc taccttttcc
    12661 gccacgaaag tcgcaggaaa ggattggccc gcaactttag tcgcgggcaa tccgttgcct
    12721 actccggaga aatcgagacc agcccggtcc gatacgcgaa gatggccagc tgaacgcggt
    12781 tatccagccc cagcttggcc agtaccctgg tcacccggct cttgaccgag gactcggtgc
    12841 tctccagttt ttccgcaatg gcggcattgg accagccggt cgccaccaac ttcaccacat
    12901 cgatctcccg ctcaccgagc agaccaattc ccctggcgac cgccggatcg ggctgcacca
    12961 tccggtgcac ggtgtgctcg atcaggcgca gggtcaccgc gggggacaac atggcatcgc
    13021 cccgggagac cacccggacc gcgtgcgcca gctcctccgg cgaggtgtcc ttgcgcagga
    13081 acccgctggc cccggcggcc agcgcggagt agacgtggaa gtcggagtcg aaggtggtca
    13141 gcatcagcac cctgggccgc ggcgccgggc cggtccactc cccgatcagc ctgcgggtgg
    13201 cgccgatgcc gtccagttcg ggcatgcgca cgtccatcag caccacgtcc gggcacagct
    13261 cggcggcctt ggccagcgcg gccaccccgg tggcggcctc gccgaccacc tcaagatcgg
    13321 ggcgcagcga gagcagggtg gacagccccg ccctgaccac cgcgtcgtcg tcgacgagca
    13381 gcaggcgaat ggtcacgaaa cgctccgcag cgggatccgc gcgtccacca cgtagccgcc
    13441 gtcgggcgcg gccgccgaac tcagctggcc acccagccgg gccaccctgg cctgcatgct
    13501 gagcagcccc agcccgctgc cgggcaccgc gggcagccgg gccgccctcg gcggctcgtt
    13561 gaccacccgc aaccgcagcg cgtcggtggc ggtgtccacg cccacctcga tgctcaccct
    13621 ggtcggcgag gcgtgcttga ccacgttggt cagtgcctcc tgcagcacca ggaatccctc
    13681 cgcgcccacc tcggggctca tcgaacgcgg cagctcggcc accgagaact ccacgtcgtt
    13741 gcccgcgttg cgcaccgcgg aagccagccg ggtcaccccc tccggcccgc agtcggcgcc
    13801 gtccgggccg tccgcgatcc cgcgcagcag gttctgcagc cggaccatct cggtcatcgc
    13861 ctgcctgctg gactcgcgga tctggttggc cgccagcacc gcctgcggat catgccgggc
    13921 cagcagctcc tcgaagacgt gcgtttgcac ggacagcgcg ctgaggtggt tgcccaccac
    13981 gtcgtgcagg tccagcgcga tccgttcgcg ttcggcgccc accgccgagc gcacctcgcg
    14041 gctgcgccgc tcgcgctgcc ggtgcacgct gcggcgcagc gagcccacgt gcgcggcgaa
    14101 gcggtgctgg tggctgccga tcatgtaggc caggcccacc gccagcgcca ccaccagcca
    14161 gtcggccagc tggatgtgct tctcatacat caggctgacg atcaccgcgt gcgccccgcc
    14221 ccagccggcc accacccagg ccacccacgg ccggtgcctg cgcgcgccgt agcggcccag
    14281 cgcgtgcgcg gcgatgagca gcgggatccc gccggtcatc tccggcaccc cgagcacgcc
    14341 gcggaccagc accatcgcgc ccacgatcag gaagatcacc accggcctgc gcctgcgcaa
    14401 cagcagcggc agggtcaccc cgtaggccgc cagcgcaccc gcggccagcc gccagggttc
    14461 ggcggggacc aggaacagcg cgagcaggtc cagcgccccg agcgcgccga ccagcagcac
    14521 gtcaggggcg ctttgccgtg cgccacgcga ccacaccgac agccgcctcc cattagacgc
    14581 ccgtgtcacc gttccgccca ccactcccag taggtaaata cctggcatcc gcgccgctca
    14641 accacccagg acagaagccg tcacctaatc ggcccaatgc ccttattgtc tgcgcaacga
    14701 cagctgccgc ctttcggtca ggactattac gcccaccgga ctactgcaca cggagccaac
    14761 cgatcgcgtc agcggctgac tcccggacag cgctgttggc gatcggctaa cctggcggat
    14821 ttcttgactc ccaaagggat cgttctgggg caacagcgcg atccggtcac aaacggaacg
    14881 tccctttggc gacaaaaagc gggcgccccc ggccatcggc cgaaagcgcc cgcttactta
    14941 ccgacgagta tcagtcgtcg ttgctgcctg gcgtgttctt cgagaccgtc atcaggaact
    15001 cgatgttggt ccgggtcttg cggagccggt ccagcagcag gtcgatggcc tgctggtcgt
    15061 ccagcgccgc cagcacccga cggagcttga tggtgaccgc cagctcgtcc ggagagagca
    15121 gcagctcctc cttccgggtg ccggaggcat ccacgtcgac cgccgggaag gtgcgcttgt
    15181 cggcgatctt gcggtccagc ttcagctccg cgttaccggt gcccttgaac tcctcgaaga
    15241 tgaccgtgtc catggtggac ccggtctcca ccagcgcggt ggcgaagatg gtcagcgaac
    15301 cgccaccctc gatgttgcgc gcggcgccga ggaagcgctt gggcgggtag agcgcggtgg
    15361 agtcgacacc accggagagg atccggcccg aggcgggggc ggccaggttg taggcgcggc
    15421 ccagccgggt gatcgagtcc agcagcacga ccacgtcgtg ccccatctcc accaggcgct
    15481 tggcgcgctc gatggagagt tcggccacgg tggtgtggtc gcccggcggc cggtcgaagg
    15541 tcgaggcgat gacctcgccc ttcaccgaac gctgcatgtc ggtgacttcc tcagggcgct
    15601 cgtccaccag gacgaccatg aggtggcact ccgggttgtt cgtggtgatc gcgttggcga
    15661 tcgcctgcag caccgaggtc ttgcccgcct tgggcgggga gacgatcagc gcgcgctgtc
    15721 ccttgccgat cggcatcacc agatcgatga cgcgcgtggt gaggatgtgc ggctcggttt
    15781 cgaggcgcag tcgctcgttc gggtacagcg gggtcagctt ggtgaattcc gggcggccgc
    15841 gcacggcctc cggctccagg ccgttgatgg agtccacccg caccagcggg ttgaacttct
    15901 gccgctgcgc ctccccgtcc cggggctggc gcacggcgcc ggtgatcgcg tcaccacggc
    15961 gcaggccgta acggcggacc agcgacagcg agacgtagac gtcgttcggg cccgccaggt
    16021 aaccggaggt gcgcacgaag gcgtagttgt ccagcacgtc gaggatgccg gccaccggca
    16081 gcagcacgtc gtcctcgcgg acctcggtgt cgccaccgcc gccgccacga ccgccccgct
    16141 cgccacggtc accgcgatct ccacggtcac cccggtccgt gccgccaccc tcgccatccc
    16201 ggccacggtt gcgccgacgg tcccggaagc ggcgtccgcg ccgtcccctg ccgtcctcgt
    16261 cctcgtcgtc ctcgacgccc tgcggctgac tctgggccgc cgcggcacgt tcgccccggt
    16321 ccccgcggtc attgcggtcg ttgcggtcgt tgcgattgcg gttgcggtcg ttccggttgc
    16381 cccggtctcc ccgctcaccg cggtcgcccc gctcaccgcg ttcctgccgc tcgccgcgct
    16441 cggcccgctc ctggcgctgc tcggccggct tctcccgctg ctcggcggcg acagcgacag
    16501 gctgctccac ctgctcgacg ggcttgtcgg cctggggctg ctccggagcg cgctcgcggg
    16561 ggttccgctg ctcgccctcc gggctcccgg ccggacgggt ggccgcccga cggcggcggt
    16621 tacgccgggc attatcgccc ccggcgtcgc cctcaccagc cgcgttgtcc gcggcggcgg
    16681 gggttgcggc gggcgccggc ggggcgctct ccaccgcggt ggccttgggc gcgggggtgc
    16741 tttcggcacc cagcgccaac tgaccggtct cggccttggc cggcttggca gcctcggcgc
    16801 gtggcgccga accgccgcct tgccgctcct tgatggcggc gatcaagtcg cccttgcgca
    16861 tcccactggt gttgccgatg cccagctcac cagcgagctg acgcagctcg gcgagcacca
    16921 tcccggaaag gccgccacga cgtcgagtcg ccgtgccatt ggccgaaggg ctggcagcgg
    16981 tcgtctcgac cgcgtcgccg cccagtagtt cggtttcgct cacgaatgtc cttcctgacc
    17041 ggtccccgcc tcctacgtgg accagcggac ttgccgcccg acggaacgcg ggacagcagg
    17101 tcgtccagta ccggtgggaa gactcggtac gggactgtca atcaccgcct cggtgtaccc
    17161 gtcagcgtgg atcccgtcct ggaggggatc gagacctagc ttcaacgggg atgcgaccca
    17221 ggaacgaggc ccgggaacgg caccggcgac cgtgcgcgcg gtgactgatt gcctctgagg
    17281 gtagaccccg ggtcaacggg gtgcaacaac cgggtgggtc ctggcgtggc gggaagggcc
    17341 ttggctacct cggctttgct ccctcagacg ggttcgcaga ccccccgatc ggttccacca
    17401 ccaccccgcc ctggtcaatg ggcagggcca tcggggtgaa cccggacagg tccgcctcgt
    17461 caggcaggtg acccccgcgc gggaaggcga tcacggtggg tcccgctccg gagaccatgg
    17521 ccgggatccc ggccgcccgc aacgagtcca ccagcgccat cgtcgccggg aaggcgggcc
    17581 tgcggtactc ctggtgcagc cggtccgcgg tgcccggcag cagcagccag ggatcggtgg
    17641 tcagggcgta gacggcgagc gcggagcgcc cggccgcgaa ggccgcgtcc cgcaacggga
    17701 cctgctccgg cagcaacccg cgtgtggtct tcgtctcgga ttcggtctcc ggcacgaaca
    17761 ccagcggcgc cagctcctca tgcggctcca accggatggc ctggtagtcc ttgccgtcct
    17821 gccaggcgat cacgatcccg ccgtagacac tggccgcggc gttgtccgcg tgcccctcga
    17881 actccgccgc gagctgcaac accccgtcat ccagctcccg gtccgccagc gcgaacccgg
    17941 ccgccacccc ggcgaccgcc gccgccgcag aggacccgag cccacgggcg tgcggaatcc
    18001 ggttccggca caccagatcc agccccagcc cggcaacccc acaactggac aaagcggacc
    18061 gcaccgcccg cacgaccaga tgccgctcat ccgtcggcac ccgccccgcg ccctggccct
    18121 cgacccgcac ccggatctcc cccgccggcg cgacccgcac ctcgacctcg tcgtagaggc
    18181 ccagcgccag cccgagcgag tcgaaccccg aaccgagatt cgccgtcgac gcgggcaccg
    18241 tgacccgcac accactaccg atccgcacca gcacacccta gatcagggca tccgggccca
    18301 accggtcctc gcgacctcgc gcacccgctt gtccaggctc tgcacgaccg agcgcggcac
    18361 atcgccgaac agacagaccg ggagcactcc gaacacctgg aaccagacca gaccgggcag
    18421 gccgtggcga cccagcatcc agggcagcag gatcgagatg gtggtgatca gcacgccgca
    18481 ggacaggatg atcagactgc cgatgaccgc ggtccgccgc cacccgggca gcgccgccac
    18541 gtcgaccagc tcgccgtaga acagcgcgcg gccctgccac aggaaggccg cggtccagcc
    18601 gaaaccgagc gcgtacaagg ggagctgccc cagcaggacg acgaagaact ccaggttggc
    18661 ccggttcagc tgtgccatca ggaaacacca caggccgagg aagaacaccg ccccaccggt
    18721 ctggacgacg ccgttcacgg cccaggcacg cctgctgcgg gccgcgccgg gtaccagctg
    18781 ccaccgcggc aacccgcttg accccggcgg cactgggaac tggctgtgct gatcgcggcc
    18841 gacgaacggc atccgctccc cctgcggtcc gggccggcgc ctcccccagc ccggcccaca
    18901 cccgaaccta gaggatcagc gatcggcccg cacccgaacc cggcaacctc gccgggtcag
    18961 tgctcgacga cctcgcccag caggctgtcc agctgttcga tcaccttgcg gttgtccacg
    19021 ccgaagaagt tgatccaccc gttgcgttcc cggctgccgc agcggccggc ctggatgtcg
    19081 aagacgttga gcacgctgct cgcgcgcacg ctgcggccgt actggtcccg cgcggtggcg
    19141 ccgaactggg cgtacagggt gcggtcggcg tcgccgattt cccagaggag ctgggcgtct
    19201 tcctggcgga cgccgcggga ggtcaggatc tggacgaaga ccttgccggc ttcggcggcc
    19261 tggctgacgg cggattccag cacgtcggcg gcgacggtga ccgagccgat gcggccgggt
    19321 gggggctggg gcagcaggcc ggcggccgcg ggggccaggc cggtgctgcg gacccagccg
    19381 aagcggtacc ggtcgccgtc gtgcacggcc agtaccccgg tgtcgccgac ggcggagcag
    19441 atcgccttga tctcgggcag gatctgctcg ccgacccgcc aggagaagcg gatgtcgatg
    19501 gaccggttgg ggcgggccag caggaccagc aggtcctcca gttccacgtc caaccggccg
    19561 tcctcggcgc ggccacgctg ttccagggaa tcccaggccc ggcggcggaa atgcgcgcgt
    19621 tcctcgtcgg tgacgccgtg ggacagcgtg ttcagctcgg tgggcttgtc gcccagttgc
    19681 aggtgctccc agagcacctc gaactccagt gcgttcagtt cgaggtcgag tgaaacagtc
    19741 acaggcccgg attctcgcca attaccggcg gcgcgaccag catgccgtcg ccgaagatgt
    19801 cgtcggtctc gatgaggtag tcaggacgct ggtgttcctt gtcttcctcg ccgttggcgc
    19861 gtgcgccacc gcccatgggg ccgcccatgc cgccggcgcc gccccggcca ccgggaccga
    19921 agccacccgc gccgccggga ccgccgaggc cacccgcgcc gaccccgccc atgccgccgg
    19981 gaccgaagcc gggccgcatg cccgccgcgt tcgcgccgaa gccgccgggc atcccgccca
    20041 tcggcatccc gccgccaccg aaggggctgg ggccgccgcc ggggccgacc ggcaccgggt
    20101 tgctgggcag cggctggttg agcacgggag tgggggtgac ccggttcggg tcgacctggt
    20161 cgttgggcag ctcgatcggg aaccggttgt cgaccgggtc ccggtcgtcg gggatgccgt
    20221 cgccgtcctt gtcccggccg gggttgcggt cgtcgaccgg gtcgcggtcg tcgaccgggt
    20281 cgcggtcgtc cgggatgccg tcgccgtccc ggtcgccgac cccgccgcgg tcgcgggtgg
    20341 tgttgttgtt gccggtgctg ccgcgccggg tgggcgtgcc ggtggtgccg ccgatctcgg
    20401 tggtgccacc gccggagctg gtcacgccga cgtcgatcgg gtcgggcgcg atgaaggtgg
    20461 gcaggttggt cgtggaggag agcaccgtgg tctcgtagcc gcgcatggtc tcgcgggcct
    20521 gacgctcggc gttgtccttg ttctgctgct cctgctgcct gtcggtcatc ccgccggtga
    20581 gcgaggccca gccacgggag atcacgttgt cgctggaggt gacctgttta ggcggctcga
    20641 tcttcttctg ggtgtccaca aaggtgttgg tgctggtctg cgacgtgctg cgcatcgtgc
    20701 cggccattgt ggaagcctgc gtggcccact ggtgcgcggg cgagacccgc tcctgcatct
    20761 ggtcgaagga cttgccctgc atgacaccgg tggccgcctc gaacgccttc ttgacgttgt
    20821 cgccgatccg gctcaggcgc tcggcctgct tctcccagag cagatcacga ctgctgaggg
    20881 catagtgccc acggccttcg ttgatcatct tgtggatctg ctcgtggctg tacgcgtccc
    20941 agttggtcat gtcctcaccc cagttgtgcc cgtgcgccct caggcccgct tcatggtgga
    21001 gcggttcgcc tgctcctggc gctcgtagtc cgcgagaccg ttcttcaagt tggtgatcat
    21061 ggcctccagg gaggcgatga gcttgtcagc ggcggccacg agcccggcgg ggccggtggc
    21121 aggcacgtcg aggcgcttgg ccagctcgac gctcgcgggg tccttggcgg gagcttcctg
    21181 ggtgccgatc gcggaggtgt actccttgag atccttggcc tccagcagct cggcctccag
    21241 cttggcgatc aggcccggca cctggtccgg cttgatcatc actcggtccg ccatgggttc
    21301 cctccagcaa cgttctccca gacaggacct aggatgtcac acggcatgac gccggttccc
    21361 cgctttgcct actcgtgacc cagctcacat ggcaaacgca aacgcaccga atcaggcagc
    21421 tgccgggagc ttctcgatca cggcggtgag cacctgctcc gcgaggccgc aggcgtcctg
    21481 ggtgacttcg ggcatgctcc ggtacgagct gaagtacgac cggagcgtct ccttggccga
    21541 gatggccacg aagaccatgc agccgcgctg gtccttgccc tccaccgagc ggaccgccgg
    21601 atagcccgcg accttggcca cgaccaggcc ggactccggc ttcggcgcgt ccagcccgaa
    21661 cttctgcagc agggtggagt tgtacagctc gacctcgacc gaggccctgc tgttctcgta
    21721 gttggtccag gtgcagctcg cggtggcggc cttgggcttg tcaggcaact tgaactcggt
    21781 gagctgagcc ggggtcagtg ccgcgcaggg ggtggtgcgg aaggcgccct cgaccgtctt
    21841 cggctgagcg gtcaccttcg tccactcccc gggggccgcg gccgacgaag tggcggcctg
    21901 ggtaccgggc ggggtgggtg tcgcgccacc cccacaggcg gtgaccagca ccgcagccga
    21961 catcagcatg gacccgagca accaacgtcg taccgtcacg cccgcagcat acggacgttc
    22021 agctgccctc gggcagcgtt gcgagaaccc gctcggccac ctgctgggcg aacgcgcagg
    22081 cgtcgggcac ggcctccggc ctggtactgg gtgagctgaa ggtcgcggcc agggcctcgg
    22141 tggcggacac gccgatccgc agcgtgcagc cacgctggtc agcgccctct ttggcgcgga
    22201 cagcggggta cccggcgacc tgcaccacgg tcactccggc cccggacggc tcgtggtcga
    22261 agcgctgggc cagggagagc tggtccagtt ccacccggac cgcggcgccg ctggcctggt
    22321 tgcgccaggt gcagccggcc ggttcctcgg cggcggcctg gaccggggcc gagggcaggc
    22381 cgacggtgcg gcgttcggcc gtggtcagcg actcgcaggg tttggtccgg aagcccttgt
    22441 ccaccgactt gggctggccg actttggtcc actccttgac caccgtgctc ggccctggct
    22501 gcggcgcggg cgcttcggcg gtgcaggcgg cgctcagtgc cgccagcagg acagcggcc
//
