LOCUS       NZ_JALMDK010000008     22804 bp    DNA     linear   CON 13-SEP-2024
DEFINITION  Crossiella sp. S99.2 NODE_8_length_427523_cov_119.458477, whole
            genome shotgun sequence.
ACCESSION   NZ_JALMDK010000008
VERSION     NZ_JALMDK010000008.1
KEYWORDS    WGS; RefSeq.
SOURCE      Crossiella sp. S99.2
  ORGANISM  Crossiella sp. S99.2
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Crossiella.
REFERENCE   1  (bases 1 to 427523)
  AUTHORS   Gonzalez-Pimentel,J.L.
  TITLE     From North to South: A Spanish map of bacteria producing bioactive
            compounds in show caves
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 427523)
  AUTHORS   Gonzalez-Pimentel,J.L.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-APR-2022) Agroquimica, Microbiologia Ambiental y
            Conservacion de Suelos, Instituto de Recursos Naturales y
            Agrobiologia, Av. Reina Mercedes 10, Sevilla 41012, Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2021
            Assembly Method                   :: SPAdes v. 3.14.1
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 200x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023094165.1-RS_2024_09_13
            Annotation Date                   :: 09/13/2024 06:26:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,481
            CDSs (total)                      :: 9,422
            Genes (coding)                    :: 9,365
            CDSs (with protein)               :: 9,365
            Genes (RNA)                       :: 59
            rRNAs                             :: 2, 1 (5S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 1 (5S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 8 of 57
            Pseudo Genes (incomplete)         :: 50 of 57
            Pseudo Genes (internal stop)      :: 4 of 57
            Pseudo Genes (multiple problems)  :: 4 of 57
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:32:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 26025
            Orig. end                         :: 48829
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JALMDK010000008.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22804
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22804
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22804
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12804](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12804
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            311..670
                     /locus_tag="MZC64_RS28640"
                     /old_locus_tag="MZC64_28655"
     CDS             311..670
                     /EC_number="5.2.1.8"
                     /GO_function="GO:0003755 - peptidyl-prolyl cis-trans
                     isomerase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019510291.1"
                     /locus_tag="MZC64_RS28640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28655"
                     /product="FKBP-type peptidyl-prolyl cis-trans isomerase"
                     /protein_id="WP_247762214.1"
                     /transl_table=11
                     /translation="MTKPEIDFQGGPPPTELVVADLTVGEGAEATPGGTVEVHYVGVEF
                     ETGEEFDSSWNRGQTIEFPLGNLIAGWQRGIPGMKVGGRRQLTVPPELAYGPAGAGHRL
                     SGKTLVFVIDLVGTR"
     misc_feature    complement(322..336)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.19"
                     /tool="antismash"
     gene            906..2114
                     /locus_tag="MZC64_RS28645"
                     /old_locus_tag="MZC64_28660"
     CDS             906..2114
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MZC64_RS28645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MZC64_28660"
                     /product="hypothetical protein"
                     /protein_id="WP_247762216.1"
                     /transl_table=11
                     /translation="MRFPISLTTVLSPSLGAPRALIDVYGPGVAVCARPAVEATGAVSG
                     SRHTRDVLSARPIGIAGDTAVICSAGGTDPILLAMLRDGGLPVGADLRAFRGEVEFAAR
                     VREAVGDGLRISMEYPQPAALCAEEHSVKSAALVGHLNNKASINTFVDPRFRARRTVVS
                     RAELAEATPVQKSWVLKAATDDAHGGSLDVCLHLADEPVTLPAFTEVLGEFVVEEYLDI
                     RRNWGIQLYVAADATARLLAVTEQHVDAAGIYTGGRFGLVTPLPAELRAECVAIAQRAA
                     DAGYRGLCSLDCAQTADGRLIMLDLNFRITSGSIPLLALQSVRPEALDRPAESVKLTVA
                     APLAELLTGLRPALAAGGLLVLAGHDTARTDNPIRQATLQLLVFGDDPAEVTARRIALE
                     AAY"
     gene            complement(2140..3297)
                     /locus_tag="MZC64_RS28650"
                     /old_locus_tag="MZC64_28665"
     CDS             complement(2140..3297)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF018434.5"
                     /locus_tag="MZC64_RS28650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28665"
                     /product="glycosyltransferase"
                     /protein_id="WP_247762218.1"
                     /transl_table=11
                     /translation="MRVAVVSGGEPGHVFPAIALCLRLIEAGDEPTLFTVGPWVDAAIE
                     AGIPVPRLTGLPLDDAGGREDLGRWQHERAAAMATALAPWIAAVRPELVVCDVLAPGGG
                     LAAELLGVPWVKLSPHPLYEPSRGLPPLGSGLAVGTGIAGRVRDSVLRAATGRAIRLGE
                     RQRARARLGLGLAAREPGPAARLIATLPALEVARPDWPGNARVVGPLLWEPTGAVLEPP
                     PGDAPLVLISASTAVAGAAGVAEATVEALAGMGVRAVVCTFGAPPAGLPDWARAGLGRQ
                     DVLLRQASVLVGGGGHGVLAKALLAGVPMVVVPGGGDQWELANRAARQGSAVIVRPPRA
                     EALRAAVSRVLGEPGFAAAALRAADLDGVWDPVRVCRDAVTGAVT"
     misc_feature    complement(2668..2670)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3370..4032
                     /gene="lexA"
                     /locus_tag="MZC64_RS28655"
                     /old_locus_tag="MZC64_28670"
     CDS             3370..4032
                     /EC_number="3.4.21.88"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="lexA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003103316.1"
                     /locus_tag="MZC64_RS28655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28670"
                     /product="transcriptional repressor LexA"
                     /protein_id="WP_247762220.1"
                     /transl_table=11
                     /translation="MTAYDDLDVFEHLDAASLPPRQQQILVTIRDWVQRHGYSPSTRQI
                     GDALGLRSSSTVSKHLTSLEDKGFLRRSASMSRPIDVRLFLRDNAAHKANEDSVTVPVV
                     GDIAAGSPITAEEHLDDQLTLPRELTGRGTVFALRVRGDSMIDAAICDGDMVVVRQTTE
                     AHSGQIVAAMIDDEATVKVYRRRNGHVYLEPRNPAYEVIDGDKAVVLGTVVSVLRSV"
     gene            complement(4040..5173)
                     /locus_tag="MZC64_RS28660"
                     /old_locus_tag="MZC64_28675"
     CDS             complement(4040..5173)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005455421.1"
                     /locus_tag="MZC64_RS28660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28675"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_247762221.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.9e-19, bitscore:
                     64.5, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 2.2e-24, bitscore:
                     80.2, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 3.1e-34, bitscore:
                     113.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFDQSPAQRARYADTVAALRELPAGTEFDRDRWQRLGALGLLGA
                     CVPADQGGQGLGALDTALQFEAAGYACPDVGLLFAAGAHLFACAMPIARFGAADLRARV
                     LPGMCTGELIAGNCMTEDGAGSDISRLSTTATAVPGGYRLNGAKAFVTNGPVADLHLVY
                     ATTDPQAGQWGITAFLVPATSEGVRVGEPLDKLGMTGAAASTVGFEDCFVAESTVLGAP
                     GQGTEIFQHSMSWERACLFALFLGVQDRLIERSAEHARDRRQFGRRLTDFQAVSHRLAE
                     AKLRVESARLLLYRACWSIDAGRPSALFTALSKLATSEGMLATATDAVRLFGWRGYLAG
                     HEVSAALGDAIGGTLFSGTSDIQRQLIALELLDQLSR"
     gene            complement(5173..5436)
                     /locus_tag="MZC64_RS28665"
                     /old_locus_tag="MZC64_28680"
     CDS             complement(5173..5436)
                     /NRPS_PKS="Domain: PP-binding (20-75). E-value: 1.2e-07.
                     Score: 23.9. Matches aSDomain:
                     nrpspksdomains_MZC64_RS28665_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012759.5"
                     /locus_tag="MZC64_RS28665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28680"
                     /product="phosphopantetheine-binding protein"
                     /protein_id="WP_247762222.1"
                     /sec_met_domain="PP-binding (E-value: 1.1e-06, bitscore:
                     23.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTLTTVDELCALIRDCVAWTEDDVPVAVTPDTELLALGLLDSLT
                     IRRIVAELAAAGVAVPDARVVAATFRSPAALWQVVTELRDAA"
     aSDomain        complement(5212..5376)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MZC64_RS28665_PP-binding.1"
                     /evalue="1.20E-07"
                     /label="MZC64_RS28665_PP-binding.1"
                     /locus_tag="MZC64_RS28665"
                     /protein_end="75"
                     /protein_start="20"
                     /score="23.9"
                     /tool="antismash"
                     /translation="TEDDVPVAVTPDTELLALGLLDSLTIRRIVAELAAAGVAVPDARV
                     VAATFRSPAA"
     gene            complement(5438..7708)
                     /locus_tag="MZC64_RS28670"
                     /old_locus_tag="MZC64_28685"
     CDS             complement(5438..7708)
                     /NRPS_PKS="Domain: Abhydrolase_1 (23-178). E-value:
                     7.8e-15. Score: 47.1. Matches aSDomain:
                     nrpspksdomains_MZC64_RS28670_Abhydrolase_1.1"
                     /NRPS_PKS="Domain: AMP-binding (266-663). E-value: 1.7e-82.
                     Score: 269.1. Matches aSDomain:
                     nrpspksdomains_MZC64_RS28670_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.5"
                     /locus_tag="MZC64_RS28670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28685"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_247762224.1"
                     /sec_met_domain="PF00561 (E-value: 3.2e-12, bitscore: 41.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.2e-16, bitscore:
                     55.3, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 3.3e-88, bitscore:
                     290.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLLDVAGGPLEYVVIDGRADLAPLVFLHHGVGSVAGWFRFHARI
                     AAATGRRVLAYTRHGYGGSAPARLPRRPDYLDHEATVVLPEVLARLGIERPILIGHSDG
                     AAIAVLYAAEPSRPVRGLALLAPLVFVEERTVRGIRSTGRKFTEGDLRAEVATIHADPD
                     GAFLGWHDTWLSPEFRDWSVLDRLGRIGQPVLVVDGTKDKYATAAQGDAVCAGVAGPVS
                     RVVVPDGMHMIHFSHPAETRAAVLDFLGAVDPEPAVERLDAALSAAAARFPDRPALAAG
                     DEVLSYAELDRAVTELAGRLSDAGRKPGERLGVLLPKGIGAVIAIYAGLRLGLVVAPLD
                     PADPAARIARMVRGAGIRFLLCGEQTLAKATRVGEGPALDLGGTSTLVPVAAADPPALG
                     VAEDGGYILFTSGSTGWPKGVLLSHRNVLHFAHWAVGELGLGPADRIGSQSALGFDLST
                     FDLFATALAGACVDLMPDHLRLFPGELLDWLDQRRISVFYAVPSLYQGMLLHGEWEQRP
                     PGALRLAVFAGEPFPPQYLERCLRAVPQVRFHNLYGPTETNVCTHEPVPPSWSALDGLS
                     IGRAIPGDFVEVLDEQGLPTDGDGEIHVAGATVFLGYLVDGELLDPAREVRFRDGVTRR
                     TYPTGDLGHFEADGRLHLRGRRDHQVKRHGHRIDLEDIESALLEVSDVDAAAVVLKSGA
                     PHAGEIWAYVVGADSLTPQRISAALAAALPRRMLPDRVLPVAGLPVNQRGKLDRAALSE
                     RSA"
     misc_feature    complement(5495..5497)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       complement(5687..5746)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MZC64_RS28670_0003"
                     /evalue="1.50E-07"
                     /label="NRPS-A_a8"
                     /locus_tag="MZC64_RS28670"
                     /protein_end="674"
                     /protein_start="654"
                     /score="23.8"
                     /tool="antismash"
                     /translation="GRRDHQVKRHGHRIDLEDIE"
     aSDomain        complement(5720..6910)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MZC64_RS28670_AMP-binding.1"
                     /evalue="1.70E-82"
                     /label="MZC64_RS28670_AMP-binding.1"
                     /locus_tag="MZC64_RS28670"
                     /protein_end="663"
                     /protein_start="266"
                     /score="269.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="AAAARFPDRPALAAGDEVLSYAELDRAVTELAGRLSDAGRKPGER
                     LGVLLPKGIGAVIAIYAGLRLGLVVAPLDPADPAARIARMVRGAGIRFLLCGEQTLAKA
                     TRVGEGPALDLGGTSTLVPVAAADPPALGVAEDGGYILFTSGSTGWPKGVLLSHRNVLH
                     FAHWAVGELGLGPADRIGSQSALGFDLSTFDLFATALAGACVDLMPDHLRLFPGELLDW
                     LDQRRISVFYAVPSLYQGMLLHGEWEQRPPGALRLAVFAGEPFPPQYLERCLRAVPQVR
                     FHNLYGPTETNVCTHEPVPPSWSALDGLSIGRAIPGDFVEVLDEQGLPTDGDGEIHVAG
                     ATVFLGYLVDGELLDPAREVRFRDGVTRRTYPTGDLGHFEADGRLHLRGRRDHQVKR"
     CDS_motif       complement(5855..5911)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MZC64_RS28670_0002"
                     /evalue="1.30E-03"
                     /label="NRPS-A_a6"
                     /locus_tag="MZC64_RS28670"
                     /protein_end="618"
                     /protein_start="599"
                     /score="11.3"
                     /tool="antismash"
                     /translation="GEIHVAGATVFLGYLVDGE"
     CDS_motif       complement(6437..6493)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MZC64_RS28670_0001"
                     /evalue="3.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="MZC64_RS28670"
                     /protein_end="424"
                     /protein_start="405"
                     /score="25.6"
                     /tool="antismash"
                     /translation="YILFTSGSTGWPKGVLLSH"
     aSDomain        complement(7175..7639)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MZC64_RS28670_Abhydrolase_1.1"
                     /evalue="7.80E-15"
                     /label="MZC64_RS28670_Abhydrolase_1.1"
                     /locus_tag="MZC64_RS28670"
                     /protein_end="178"
                     /protein_start="23"
                     /score="47.1"
                     /tool="antismash"
                     /translation="PLVFLHHGVGSVAGWFRFHARIAAATGRRVLAYTRHGYGGSAPAR
                     LPRRPDYLDHEATVVLPEVLARLGIERPILIGHSDGAAIAVLYAAEPSRPVRGLALLAP
                     LVFVEERTVRGIRSTGRKFTEGDLRAEVATIHADPDGAFLGWHDTWLSPEF"
     gene            complement(7734..8558)
                     /locus_tag="MZC64_RS28675"
                     /old_locus_tag="MZC64_28690"
     CDS             complement(7734..8558)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020666737.1"
                     /locus_tag="MZC64_RS28675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28690"
                     /product="thioesterase family protein"
                     /protein_id="WP_247762226.1"
                     /transl_table=11
                     /translation="MGDFLTATALVARGATAGAHEFGVDLDGQWALADKPNGGYLLAVL
                     GRAAAAVSGAEHPHLTAISGSFIQSPAPGPAVVTAEVLRAGRGSTQVRARLSQDGVPRV
                     EALITQGLLADAEPWWSGAEPVELPPLADCPRSPVEAPGGAFRIHLLEVVEQYLDPAML
                     GFMRGKPTGRGVFAGWLRLADGSDWDPLSLLVALDALPPVGYDLGVPGWSPTVQFSAYV
                     RGLCAPGPIRVRAAAGEVGGGHVDESVSAWDSKGRLVAQGRQVASVRLPGQG"
     misc_feature    complement(8823..8843)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.91"
                     /tool="antismash"
     gene            8938..9879
                     /locus_tag="MZC64_RS28680"
                     /old_locus_tag="MZC64_28695"
     CDS             8938..9879
                     /codon_start=1
                     /gene_functions="regulatory (extras) StrR_like: StrR-like
                     pathway specfic regulators"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020636716.1"
                     /locus_tag="MZC64_RS28680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28695"
                     /product="ParB N-terminal domain-containing protein"
                     /protein_id="WP_247797762.1"
                     /transl_table=11
                     /translation="MVPIDSIIPADSPRRDGEDPEHIRALAEFEGALPPILVRRDNSQV
                     IDGMHRLKAAILNGRYEIEVRFFDGDENAAFVLAVEANIAHGLPLSLGDRESAAQRILE
                     VYPQWSDRAIAGAAGLSPKTVAALRRRAGEDTAAPDARVGRDGRVRPLSTAEGRRIAGE
                     TFAHSPGASLRAVARTAGISVSTAKDVRDRVSRGEDPVPPKLRALEQGANQPRTRDIPR
                     GDHHPARDGGHRGKDAILRILQQDPSLRFTETGRLLLRWLATHAIGPEDWADRLDTMPP
                     HSRAVVADLAIGCAEAWREFAEELRTGTRVTA"
     aSDomain        10001..10171
                     /aSDomain="Lasso_Fused_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing fused peptidase in a lasso
                     peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_MZC64_RS28685_Lasso_Fused_RRE.1"
                     /evalue="8.80E-09"
                     /identifier="RREFam003.1"
                     /label="MZC64_RS28685"
                     /locus_tag="MZC64_RS28685"
                     /protein_end="57"
                     /protein_start="0"
                     /score="26.3"
                     /tool="antismash"
                     /translation="MGLTFREHVSVAETEYGVVLLDTRTGNYWQLNPTAAVAAKVLVDG
                     GDPAGAAQRLVE"
     gene            10001..10258
                     /locus_tag="MZC64_RS28685"
                     /old_locus_tag="MZC64_28700"
     CDS             10001..10258
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670106.1"
                     /locus_tag="MZC64_RS28685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28700"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_247762233.1"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 1.3e-07,
                     bitscore: 26.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.8e-23,
                     bitscore: 77.2, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4.7e-15, bitscore: 50.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLTFREHVSVAETEYGVVLLDTRTGNYWQLNPTAAVAAKVLVDG
                     GDPAGAAQRLVEEFEVDDDVAAADVTALVDALRAAGVVTG"
     aSDomain        10010..10252
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_MZC64_RS28685_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.20E-24"
                     /identifier="RREFam002.1"
                     /label="MZC64_RS28685"
                     /locus_tag="MZC64_RS28685"
                     /protein_end="84"
                     /protein_start="3"
                     /score="77.2"
                     /tool="antismash"
                     /translation="TFREHVSVAETEYGVVLLDTRTGNYWQLNPTAAVAAKVLVDGGDP
                     AGAAQRLVEEFEVDDDVAAADVTALVDALRAAGVVT"
     gene            10255..10692
                     /locus_tag="MZC64_RS28690"
                     /old_locus_tag="MZC64_28705"
     CDS             10255..10692
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015802122.1"
                     /locus_tag="MZC64_RS28690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28705"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_247762235.1"
                     /sec_met_domain="PF13471 (E-value: 2.3e-24, bitscore: 80.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVLGALHRDQFPPRTRAMRLRAQVAVLLARVLARLKPHHLQRVL
                     ARLSRGARPATFAQAMAARRVVLAGRISLHGVKACLPRSLSAVLLCRAYGVWPTWCVGV
                     GARPPFGAHAWIEVGEKLVGEPGEHRDWVRLITVPPLSEPA"
     misc_feature    complement(10723..10737)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.38"
                     /tool="antismash"
     gene            10987..12804
                     /locus_tag="MZC64_RS28695"
                     /old_locus_tag="MZC64_28710"
     CDS             10987..12804
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.5"
                     /locus_tag="MZC64_RS28695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28710"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_247762812.1"
                     /sec_met_domain="Asn_synthase (E-value: 3.4e-32, bitscore:
                     107.1, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESQELPFFFVFPDREDAREPAERAQRQATGARVLRHPSGRPWIV
                     GRWDDHEFLLARAGSTMLALAGTFDLDQAELTRRAALTRSAADLCTTTRSWPGSFHLVA
                     SVDGETLVRGTAYGSRRVFTTRVGDAVLAGDRAAALAALVNAPVDRGAVALRLVQPLPV
                     ELAERAMWQGIEAVRPGEYLLAHSTGGATRNRWHHPPTPDLPLEAGAARTRTALATAVS
                     VRTAGGGTVSLDLSGGLDSTSLCFLASRHANGANLLACTLLLDERVNDDGVWTRRALEQ
                     LPDLGHLMVPTADVPLFYEGAFDPRDRWDFPSRITLSRRRAVVAQTLMAAKGSRLHLTG
                     NGGDHLFFGAPNHFHATALRHPLLTLSRLRGYRALDSWRWRAVLAQLTDRRGYRAWLAG
                     LTVRDSTPMAPDTPRLRWTAPLQVPSWLTPDCLDLIDTELQAAARTAHPLASTPGTHAE
                     LADIRSSTEDMRALDDISRLAGVPTTHPYFDDHVVDAALSVRIEDRVTPWRYRPLQVAA
                     LRGIVPPRSLSRATKAEATQDAELGLIRHREELVALWTNAALGHQGLVDANAVRRIVTS
                     PTSPELRDQGLMTTLMTETWLRSATTSAW"
     misc_feature    13141..13154
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    complement(13157..13171)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.34"
                     /tool="antismash"
     gene            13162..13374
                     /locus_tag="MZC64_RS28700"
                     /old_locus_tag="MZC64_28715"
     CDS             13162..13374
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MZC64_RS28700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MZC64_28715"
                     /product="hypothetical protein"
                     /protein_id="WP_247762236.1"
                     /transl_table=11
                     /translation="MTINVGAGRPVFKVTKIGKGGVDFSLSYPTGTRATLTLDKVGAFA
                     LFGEFKITQSEWDGNGLAEVEVATK"
     gene            complement(13733..15646)
                     /locus_tag="MZC64_RS28705"
                     /old_locus_tag="MZC64_28720"
     CDS             complement(13733..15646)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004562232.1"
                     /locus_tag="MZC64_RS28705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28720"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_247797758.1"
                     /transl_table=11
                     /translation="MDGTAGVGKTTLAVHWAHRVQHHFPDGTLFVNLRGYDPTTPATTD
                     EVLPAFLHALGVPPENLPPSLHAQTGLYRSILAGRRVLIVLDNASSTDQVRQLLPGTAG
                     CLVLITSRASLTGLVIGHSATRLTLDLLTPAEAHQLLHTLLGPARLAAEPEATATLIHY
                     CARLPLALRLAAGHALAYSHTTLSELAAEMADARHRLDLLTDTDDPTLAVRAVFAWSYQ
                     RLTDNHARLFRRLGLHPGPEFSLAASAAIAGTELDRARRLLTSLTQAHLVQQTARDRYR
                     FHDLLRAYASELADTEDHPDDQTRLHQVVLEWYAHHAKAALQVASPAHSSWYPPLEIPT
                     SAYPEVVFTDPAEAWNWVRAEWDNLVAAARRATERNPVELALLLWTAVSWFSLYRARFG
                     EARELLQLCGMLARRIGDRITECTVLQMTGEHLAHLGRWDEALDVYWDALALARELGDP
                     WREACSLLDLGSWCNKQGRHADALGHLWEALPLCPGAQHGRLEGVIECQISAALAGLGD
                     FEQALPHAERGVMLRRHAGDNIGEAWSLEQLARACQGLGRHQQAIAVCEQALSNTERFF
                     LLGRAGVLDTLGVSLGHTGDTTRAIACWREALAIYEDFEDYRAADLHERLRMLDPGGHG
                     PG"
     misc_feature    complement(13823..13825)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    15678..15692
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.28"
                     /tool="antismash"
     gene            15716..15931
                     /locus_tag="MZC64_RS48855"
                     /old_locus_tag="MZC64_28725"
     CDS             15716..15931
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MZC64_RS48855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MZC64_28725"
                     /product="hypothetical protein"
                     /protein_id="WP_247762239.1"
                     /transl_table=11
                     /translation="MLGTAGEPGRGQGQLPGNDRGLPRLVEGEVVDGASLDHGTEIAAV
                     HLIVGVRAPAVHAIEFVRTAPAVGRC"
     gene            16115..16396
                     /locus_tag="MZC64_RS28715"
                     /old_locus_tag="MZC64_28730"
     CDS             16115..16396
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MZC64_RS28715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MZC64_28730"
                     /product="hypothetical protein"
                     /protein_id="WP_247762241.1"
                     /transl_table=11
                     /translation="MLLFGNRHKLELLAALARAGDNGVNLSDLAVQQGVAASVYYPPIN
                     DLLRAGLVDKLPQRLPDRRRWYRRAEGSVWEPMGVLAEGLATIEVKAS"
     gene            16393..17022
                     /locus_tag="MZC64_RS28720"
                     /old_locus_tag="MZC64_28735"
     CDS             16393..17022
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MZC64_RS28720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MZC64_28735"
                     /product="hypothetical protein"
                     /protein_id="WP_247762243.1"
                     /transl_table=11
                     /translation="MTTAMAAAVRAASTTVAGSVPLADASRVETAVVRMFGFTVGLVYE
                     PDAVEVPRRAGYADQPDAPSMAFLDTLMNLPVDQPVALRDLTERQRQHLRAAPPLTVEV
                     DRHHVTRLAVAPVRTRFALVAAKDWATGLKRAGRFTPFCAKALVLRALPADSSDLLMRA
                     SFYGTGVCVFDGHELDMVVEPCRYVRKRHTPAHWWFEEEVYARIRA"
     gene            complement(17012..18226)
                     /locus_tag="MZC64_RS28725"
                     /old_locus_tag="MZC64_28740"
     CDS             complement(17012..18226)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MZC64_RS28725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MZC64_28740"
                     /product="hypothetical protein"
                     /protein_id="WP_247762245.1"
                     /transl_table=11
                     /translation="MIEKSLPGQPHQGAMQLAPDARAAALQALSLAPKPAAPAGPVGEL
                     TDRVLVHACFDTGYQLLDLLPSDVSGLVLRGAKANSGITKLRHNRYQGALVPDPEGYTR
                     AAATEDEPFALPTEGGLFPVSLNDVLQAQLDAGATAAMTPTGYLPAGQPAPLKAAARLV
                     ERLDRDDFLFSVPIAVAWLSHDHFPQLLAILKRLTVPKAIMLGGQYDPMDRKKGVVANL
                     RRLVAEAGHVAVFRTDLTAFDAMSHGAFAASIGTGGSLRHVVPFGQIPLAGKGKEKDRS
                     PSVLFPELMSFHKGNLLAERFANLETPPACWCGSCHGRKLDTFLDKPDSLAAHAHGVHI
                     WNEWGAEMRAQRVLGERAEWWQKRCQKAIDHCDTVNIEIGREDAFDAPGPLKAWAGLPI
                     WPSTP"
     gene            complement(18223..19362)
                     /locus_tag="MZC64_RS28730"
                     /old_locus_tag="MZC64_28745"
     CDS             complement(18223..19362)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017885.5"
                     /locus_tag="MZC64_RS28730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28745"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_247762247.1"
                     /transl_table=11
                     /translation="MPADVVAIAQPRMLVLARESRGWKQGDVAKAMKALDGDDSKVSQA
                     YVSRAESGKLPVSGDRLDLYANALGYPAELLTLERGEIGAGAGLIHHRKQQAVAAPELR
                     RIHAILNLTRVQLAGLLDGVPRSIEAKIPQIAVDDYLSPEEAADELRAEWGLPGGPIDS
                     IIAILEAAGGLVLARSLVAPAPLNSGNDSVPVDAVSSCTPGEDPIVLLNAGTPGDRQRF
                     TLAHELGHMVMHTIPHPDQEKQANRFAAQLLMPAKDIRANFQGAVDLRLLLSLKEQWHV
                     SMWALLRRAHTLDEISDWQYRTLAVQMASLGYRTTEPSSLDPEQPVAVRAAVDWRLDHG
                     SDVDSLARAALLRPEEFTCLYLGSTTRLPISTITAEVRT"
     gene            complement(20105..21061)
                     /locus_tag="MZC64_RS28735"
                     /old_locus_tag="MZC64_28750"
     CDS             complement(20105..21061)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635002.1"
                     /locus_tag="MZC64_RS28735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28750"
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="WP_247762248.1"
                     /transl_table=11
                     /translation="MGTELERLAASLPKMWASFLRDWDRTLRAGNYPATTRYNYLLAAV
                     QLARYLAEYAAEVEAHDAAEDPTAVRKEHVEAFQAWMIKTRSPATALNKHKGLKQFFKW
                     LLFDEEEIDRSPMERVRQPKTTKRLVPVIRDDDTKLVLATCKPKAFIHVRDEAIIRLYY
                     NTGARLSEVGRLLTEDIDLKLDSVRYHGKGDKERRVRFGPKTARAISRYLRLRDNHVGA
                     NLPNLWLAERGRRALAPNGIKIMLRRRGAAAGLQRVHAHRWRHNFAHEWKLAGGDTGDL
                     MLLLGWNSEDMPRHYGASAAAERAQETQLRMGIGENV"
     gene            complement(21251..22144)
                     /locus_tag="MZC64_RS28740"
                     /old_locus_tag="MZC64_28755"
     CDS             complement(21251..22144)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013704.5"
                     /locus_tag="MZC64_RS28740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28755"
                     /product="TRM11 family methyltransferase"
                     /protein_id="WP_247762250.1"
                     /transl_table=11
                     /translation="MTGHSPNSGPSSVWMTGERTLADQLRCGGYTPATQFDHEQVPPKI
                     AAHAIAALSRPGDLVLDPDCGAGTVPTEALYADRRAIGLTSNPRWRRVARRNITAARRN
                     GAQRPGTVITGDASLLRDAEATGLAGQVDLVLTGFRMTDRTPTESVPDTDCERLAEGLS
                     FCRPLLRAGGRIVVIIRPVRYGGALLDLPARVLEAGSAVGFVPMQRGIALTARVRGHRV
                     ITRAGFAERQAAARACAGGVPVALTAHYDVVIFQAPVFPDSLANNAITGWQPAPATALS
                     GRLLTSEPDPDRKWAT"
ORIGIN
        1 gttcctcggc aagagcctga gcgggcccga gttcgtccgg gtggtcaagg accagttcga
       61 ccagctctac gccgattccg cggacagcgg ccgggtgatg gccctggccc tgcacccgtt
      121 cgtgatcaac cagccgttcc ggcaccggta tctggaagag gcactggagt acgtggtcaa
      181 ccaccccggg gtctggctga ccacgagcga cgagatcgcc gagcactacc gctccgtgtc
      241 gtgagcccgc gccccggcgg ctacggtggg cgcgatccgc tgacggcgag aaaatgaagg
      301 gatccgacgc atgacgaagc cggaaatcga cttccagggt ggcccgccgc ctaccgaact
      361 cgtggtggcc gacctgacgg tgggggaggg cgcggaagcg acccctggcg gcacggtcga
      421 ggtgcactac gtcggcgtgg agttcgagac gggcgaggag ttcgactcct cctggaaccg
      481 cggccagacc atcgagttcc cgctgggcaa tctgatcgcg ggctggcagc gcgggatccc
      541 cggcatgaag gtcggcggac ggcggcagct caccgtcccg ccggaactcg cctacggccc
      601 cgcgggcgcc gggcaccggc tctccggcaa gaccctggtg ttcgtgatcg acctggtcgg
      661 cacgcgctga ccctggcgtg accacgcccg caccccgcga tcactcgcgg gtgcgggcgt
      721 tctgctgtcc gccgccgccc cgctgggcaa tacggccggg acgtgagact gtgggggcag
      781 gctcgcgagt atcgatcggc ccgtcaccgg aagccgactc gccagggccg gattcgtcgt
      841 cacccgtacg gcccaagtcg cgttacgccc gtgccggggc gtcgccgtcg ccaccccgct
      901 acctcatgag gttccccatc agtctgacca ccgtcctgtc gccgtcgctc ggcgcccccc
      961 gtgctctcat cgatgtctat ggtcccggcg tcgccgtctg cgctcgtccc gcggtggagg
     1021 ccaccggggc ggtcagcggc tcccggcaca cccgcgatgt gctttccgcc cggccgatcg
     1081 gcatcgccgg ggacaccgcg gtgatctgca gcgcgggtgg caccgacccg atactgctgg
     1141 cgatgctgcg cgacggcggg ctaccggtcg gcgcggacct gcgggccttc cgcggtgagg
     1201 tggagttcgc ggccagggtg cgggaggcgg tcggggacgg gctgcggatc tcgatggaat
     1261 acccgcagcc ggccgcgttg tgcgcggagg agcactcggt caagagcgcg gcgctggtcg
     1321 ggcacctgaa caacaaggcg agcatcaaca ccttcgtcga cccgcggttc cgggcccggc
     1381 gcaccgtggt ctcccgcgcg gaactggccg aagccacccc ggtgcagaag tcctgggtgc
     1441 tcaaggccgc caccgacgac gcgcacggcg gcagcctgga cgtgtgcctg cacctggccg
     1501 acgagccggt cacgctgccc gccttcaccg aggtgctcgg cgagttcgtg gtcgaggagt
     1561 acctggacat ccggcgcaac tggggcatcc agctctacgt cgccgccgat gccaccgccc
     1621 gcctgctcgc cgtcaccgaa cagcacgtcg acgcggccgg gatctacacc ggcggccgct
     1681 tcggcctggt caccccgctg cccgcggagc tgcgcgcgga atgcgttgcc atcgcccagc
     1741 gtgccgccga cgccggctac cgcggcctgt gcagcctgga ctgcgcgcag accgccgacg
     1801 gcagactgat catgctggac ctgaacttcc gcatcaccag cggctcgatc ccgttgctgg
     1861 cactgcaatc cgtccggccc gaggccctcg atcgcccggc cgagtcggtg aagctgacgg
     1921 tggccgcgcc actggccgag ctgctcaccg ggttgcgccc ggcactggcc gcgggcggcc
     1981 tgctggtgct ggccgggcac gacaccgcgc gcaccgacaa cccgatccgc caggccaccc
     2041 tgcaactgct cgtcttcggc gacgacccgg ccgaggtgac cgcccggcgc atcgccctgg
     2101 aagccgcgta ctgagtccgg ctcgcgtcac cggtgccgct cacgtcacgg caccggtgac
     2161 cgcgtcccgg cacacccgca ccggatccca caccccgtcc agatcggccg cccgcaacgc
     2221 cgcggccgcg aaccccggct cgcccagcac ccgggaaacc gccgcccgca acgcttctgc
     2281 ccgcggcggc cgcacgatca ccgcactgcc ctgccgtgcg gcccggttgg ccagctccca
     2341 ctgatccccg ccacccggca ccaccaccat cggcactccc gccagcagcg ccttggccag
     2401 caccccgtgc ccgccgccac cgaccagcac ggaagcctgc cgcagcaaca catcctgccg
     2461 ccccagcccc gcccgcgccc agtccggcag cccggcgggt ggcgccccga acgtgcacac
     2521 caccgcccga acccccatac ccgccaacgc ttccacggtc gcctcggcca cccccgccgc
     2581 cccggccacc gcggtcgaag ccgagatcag caccagcggc gcgtcccccg gcggcggttc
     2641 cagcacggca ccggtcggct cccacagtaa cggccccacc acccgcgcgt tccccggcca
     2701 gtccggccgc gccacctcca acgccggcaa cgtcgcgatc aaccgcgccg ctggtccggg
     2761 ttcccgcgct gccaacccga gtcccagccg agcccgcgcc cgctgccgct cacccaaccg
     2821 gatcgcccgc ccggtggccg cccgcaacac cgaatcccgc acccgcccgg cgatcccggt
     2881 ccccaccgcg agcccactgc ccagcggcgg caacccccgc gagggctcgt acagcggatg
     2941 cggcgacaac ttcacccacg gcacccccag cagttccgcg gccaacccac ctcccggcgc
     3001 gagcacatcg cacaccacca gctccggccg caccgccgcg atccacggcg ccagcgcggt
     3061 ggccatcgcc gccgcccgct cgtgctgcca ccgccccaga tcctcccgcc cacccgcatc
     3121 gtccaggggc agcccggtca gccgcggcac cggaatcccc gcctcgatcg cggcgtccac
     3181 ccacggcccc acggtgaaca gcgtcggctc gtccccggcc tcgatcagcc gcaggcacaa
     3241 cgcgatcgcc gggaaaacat gccccggctc acccccggac accaccgcca cccgcatacc
     3301 ggcaccctgc cacacccgtt accacgcccg cccgcccgcg gtccagaccg gacctctacc
     3361 attccgctgg tgaccgccta cgacgatctt gacgtgttcg agcacctgga cgccgcgtcc
     3421 ctgccgccgc ggcagcagca gatcctggtc acgatccggg actgggtcca gcggcacggc
     3481 tactcgccga gcacccggca gatcggcgac gccctcggcc tgcgttcgtc ctccacggtg
     3541 tccaagcacc tgacgagcct ggaggacaag ggattcctgc gccgcagcgc gtccatgtcc
     3601 cggccgatcg acgtccggct gttcctgcgg gacaacgccg cgcacaaggc gaatgaggac
     3661 tcggtcaccg tccccgtcgt cggcgacatc gccgcgggca gcccgatcac cgccgaagag
     3721 cacctggacg atcagctgac tttgccccgc gaactcaccg ggcgcggcac cgtgttcgcg
     3781 ctgcgcgtcc gcggtgactc catgatcgac gccgccatct gcgacggcga catggttgtg
     3841 gtccggcaga ccaccgaggc gcactccggt cagatcgtgg ccgccatgat cgacgacgag
     3901 gccaccgtca aggtctaccg ccgccgcaac ggccacgtct acctggagcc ccgcaacccg
     3961 gcctacgagg tcatcgacgg ggacaaggcc gtggtgctgg gcaccgtggt ctcggtgctg
     4021 cgcagcgtct gaccagccgc tacctgctga gttggtcgag cagttccagg gcgatgagct
     4081 ggcgctggat gtcggaggtg ccggagaaca gggtgccgcc gatcgcgtcg cccagcgccg
     4141 ccgacacctc gtgcccggcc aggtagccgc gccagccgaa caaccgcacc gcgtcggtcg
     4201 cggtggccag catgccctcc gaagtggcca gtttggacag tgcggtgaac agcgcggacg
     4261 ggcgtccggc gtcgatcgac cagcaggccc ggtagagcag cagccgggcg gactcgaccc
     4321 ggagtttcgc ctcggccagg cggtgcgaga cggcctggaa atcggtgagg cggcggccga
     4381 actggcggcg gtccctggcg tgttcggcgc tgcgttcgat caggcggtcc tgcacgccca
     4441 ggaacagcgc gaacaggcag gcgcgttccc aggacatgga gtgctggaag atctcggtgc
     4501 cctggccggg agcgcccagc accgttgact ccgcgacgaa acagtcctcg aagccgacgg
     4561 tgctcgcggc ggcgccggtc atgccgagct tgtcgagagg ctcgccgacg cgcacgccct
     4621 cgctggtcgc ggggaccagg aaggcggtga tgccccactg gcctgcctga gggtcggtgg
     4681 tggcgtagac caggtgcagg tcggcgaccg gaccgttggt gacaaaggct ttcgcgccgt
     4741 tgagccggta gccgccgggc accgcggtgg cggtggtgct cagccgggag atgtcggaac
     4801 cggcgccgtc ctcggtcatg cagttgcccg cgatcagctc gcccgtgcac atcccgggca
     4861 gcaccctggc gcgcaggtcc gcggcgccga agcgggcgat cggcatggcg caggcgaaca
     4921 ggtgcgcgcc cgcggcgaag agcaggccga catcgggaca ggcatatccc gcggcctcga
     4981 actggagtgc cgtgtccagg gcgccaagtc cttggccgcc ttggtctgcc ggcacgcagg
     5041 cacccagcag cccgagtgcg ccgagccgct gccagcggtc gcggtcgaac tccgtaccgg
     5101 cgggcagttc ccgcagcgcc gccacggtgt cggcgtaccg cgcgcgctgg gcgggggact
     5161 ggtcgaagtc catcaggccg cgtcgcgcag ttcggtgacg acctgccaca gcgcggccgg
     5221 gctgcggaag gtcgccgcga ccacccgggc atccggcacg gccacgccgg ccgcggcgag
     5281 ttcggccacg atgcgccgga tggtcagcga gtccagcaaa cccagggcca gcaactcggt
     5341 gtccggggtg accgccaccg gaacatcgtc ctcggtccag gccacgcagt cgcggatcag
     5401 cgcgcacagc tcgtcgacgg tggtcagggt cggcacgtca ggcactccgt tcggacaggg
     5461 cggctcggtc gagcttcccg cgttggttca ccggtaatcc ggccaccggc agtacccggt
     5521 caggcagcat ccggcggggc agtgcggccg cgagtgcggc ggatatccgt tgcggggtca
     5581 gggaatccgc gccgaccaca tacgcccaga tctcaccggc gtgtggtgcg ccggacttga
     5641 gcaccaccgc ggcggcgtcc acatcggaca cttcgagcag tgcgctttcg atgtcctcca
     5701 ggtcgatgcg gtgcccgtgc cgcttcacct ggtggtcccg ccggccgcgc aggtgcagcc
     5761 tgccgtccgc ttcgaagtgg ccgaggtcgc cggtcgggta ggtgcgccgg gtcaccccgt
     5821 cccggaaacg gacctcgcgg gccgggtcga gcaactcgcc gtcgaccagg tagccgagga
     5881 acacggtcgc gcccgccacg tggatctcgc cgtcgccgtc ggtcggaagt ccttgctcgt
     5941 caaggacttc cacgaagtcg ccgggaatgg cccggccgat cgacaggccg tccagggccg
     6001 accaggacgg cggaacgggt tcgtgcgtgc acacattcgt ctcggtcggg ccgtagaggt
     6061 tgtggaaccg cacctgcggc acggcacgca gacagcgctc caggtactgg ggcgggaaag
     6121 gctccccggc gaacacggcc agccggagag cgcccggcgg ccgctgttcc cactcgccgt
     6181 gcagcagcat gccctggtac agcgagggca ccgcgtagaa caccgagatc cggcgctgat
     6241 ccagccagtc gagaagctcg ccagggaaca gccgcaggtg gtcgggcatc aggtcgacgc
     6301 aggccccggc cagcgcggtg gcgaacaggt cgaaggtgct caggtcgaag cccagcgcgg
     6361 actgcgagcc gatccggtcc gcaggcccca gccccagttc gccgaccgcc cagtgggcga
     6421 agtgcagcac gttgcggtgc gacagcagca cgcccttggg ccacccggtg ctgcccgagg
     6481 tgaacaggat gtacccgccg tcctcggcga ctccgagcgc gggcgggtcc gccgcggcga
     6541 ccggaaccag ggtgctcgtg ccgccgaggt ccagcgccgg tccctcgccc acccgggtcg
     6601 ccttggccag ggtctgctcg ccgcacaaca ggaatcggat gcccgcgcca cgcaccatcc
     6661 gcgcgatccg ggccgctggg tcggccgggt ccagcggcgc caccaccagg cccagccgca
     6721 gcccggcgta gatcgcgatc accgcgccga ttcccttggg tagcaacacc ccaagccgct
     6781 cacccggttt gcggcccgcg tcggagagcc gtccggccag ctcggtgacg gcccggtcca
     6841 actcggcgta gctgagcacc tcgtccccgg cggccagcgc gggccggtcc gggaaccggg
     6901 ccgccgcggc cgacaacgcg gcgtccaggc gttcgacggc gggctccgga tcgaccgcgc
     6961 ccaggaagtc cagcaccgcc gccctggtct ccgccggatg actgaagtgg atcatgtgca
     7021 tgccgtcggg caccacaacc ctggacaccg gcccggcgac cccggcgcac accgcgtcac
     7081 cctgggccgc ggtggcgtac ttgtccttgg tgccgtccac caccagcacc ggctgcccga
     7141 tccggcccag ccggtcgagc acactccagt cgcggaactc cggcgacagc caggtgtcgt
     7201 gccagccgag gaaagcgcca tccggatcgg cgtggatggt ggccacctcg gcccgcaggt
     7261 cgccctcggt gaacttccgc ccggtcgagc ggatcccgcg cacggtgcgt tcctccacga
     7321 acaccagcgg cgccagcaac gccagcccgc gcaccggccg cgacggctcg gccgcgtaca
     7381 gcaccgcgat cgccgccccg tcactgtgtc caatgaggat cggacgctca atgcccaagc
     7441 gggccagcac ttccggcagc accacggtcg cctcgtggtc gaggtagtcc ggccgacgcg
     7501 gcaaccgcgc gggcgccgaa ccgccgtagc cgtgccgggt gtaggccagc acccgccgcc
     7561 cggtggcggc cgcgatccgc gcgtggaacc ggaaccagcc cgcgaccgag ccgaccccgt
     7621 gatgcaggaa caccaacggc gccaggtccg cgcgcccgtc gatgaccacg tactccagcg
     7681 gcccgcccgc gacgtcgagc aacggcatca cagcaccccc gagcccggcc ggctcaaccc
     7741 tgaccgggca gccggaccga agccacctgc cgcccctgcg cgaccagcct gcccttgctg
     7801 tcccaggcgg agaccgactc gtccacatgc ccgccgccga cctcgcccgc ggccgcgcgc
     7861 acccggatcg gccccggcgc gcacagtccg cggacatagg cgctgaactg caccgtcggc
     7921 gaccagccgg gcacgccgag gtcgtaaccc accggcggca acgcgtccag ggcgaccagc
     7981 aggctcaacg gatcccagtc gctgccgtcg gccagccgca gccacccggc gaacacaccc
     8041 cgcccggtcg gcttgccccg catgaacccg agcatcgccg gatcgaggta ctgctccacc
     8101 acttccagca ggtggatccg gaacgcccca ccgggcgcct ccaccggcga gcgcgggcag
     8161 tccgccaacg gcggcaactc caccggctcc gccccggacc accacggctc cgcgtcagca
     8221 agcagaccct gggtgatcaa cgcttctacc cgcggcaccc cgtcctggct caaccgcgcc
     8281 cgcacctggg tcgacccgcg cccggcccgc aggacctccg cggtgaccac ggccggtccg
     8341 ggggcggggg actggatgaa ggagccgctg atcgcggtga gatgcggatg ctccgccccg
     8401 gagaccgcgg cggcggcccg gccgagcacc gcgagcagat agccgccgtt gggcttgtcc
     8461 gcgagcgccc actgaccgtc caggtcaacc ccgaactcgt gcgcaccggc cgtcgcgccc
     8521 cgcgccacca gcgcggtcgc cgtcaagaaa tcccccaccc gcggttcctt ccccacccag
     8581 aagccagacg agtccgaccc tacctgggta agtcgcggac cggtggtttt gtgcccgtag
     8641 gggcatccag cggggtaaca cccgatgcac aacaggttga cccactcgca gaaggcggtg
     8701 tccgggacaa tccggacacc gcccttcaag tattcctgaa caccccttca atcctgcctg
     8761 aatacccgcc tgtgaagatc aaagaatctg cataccgcca gcgtcggacc ggcatccatt
     8821 ggtaatcttc ggacggccgc aatgacacga tggccgaatc acgtgctgga ctggtgcagg
     8881 gggttgtgcg tgcggtctgc ccgcgaatgc gattcgaccg aatgggacac catcacaatg
     8941 gtgccgatcg actcgatcat cccggcggac tcacctcgcc gtgacggtga ggatcctgag
     9001 cacatccgtg cgctcgccga gttcgagggc gccctcccgc caatactcgt acgccgggac
     9061 aacagtcaag tcatcgacgg gatgcaccgg ctcaaagcgg ccatcctgaa tgggcgatac
     9121 gagatcgaag tccgtttctt cgacggggac gaaaacgccg cttttgtgct cgccgtggaa
     9181 gccaacatcg cgcacggtct gccgttgtca ctcggcgatc gcgaatccgc ggcccagcgc
     9241 atcctggagg tctatccgca gtggtccgac cgggccatcg ccggcgccgc cggactgtcc
     9301 ccgaaaacgg tcgcggcact gcgccgccgg gcaggcgagg acaccgcggc gccggatgcg
     9361 cgggtcggcc gggacggccg ggtccgtccg ctgagcaccg ccgaaggcag gcggatcgcc
     9421 ggcgagacct tcgcgcacag ccccggcgcc tcgctgcgcg cggtcgcgcg gaccgcgggg
     9481 atctcggtca gcaccgccaa ggacgtccgg gaccgggtgt cccgcggcga ggacccggtg
     9541 ccgcccaagc tccgcgccct cgaacagggc gcgaaccagc cgcggaccag ggacatcccc
     9601 cgcggcgacc accaccccgc ccgcgacggc gggcaccggg gcaaggacgc gatcctgcgg
     9661 atcctccagc aggacccgtc cctgcggttc accgagaccg gtcggctgct gctgcgctgg
     9721 ctcgccacgc acgccatcgg cccggaggac tgggccgacc gcctggacac gatgccgccg
     9781 cactcccgcg cggtggtcgc cgatctggcc atcgggtgcg cggaggcctg gcgcgagttc
     9841 gccgaggaac tgcgcaccgg cactcgggtg acggcctgac tacgcccttt ccgcgtgccg
     9901 cggtgtgcga ctgaggtcat tccacagttg cacgacagtg ggcggcctgc ggtcgccgag
     9961 tggggaaaga actgttcgtc cgagtgaagt gggtggcgag atgggattga ccttccgtga
    10021 gcacgtttcg gtcgcggaaa ccgaatacgg tgtcgtgctg ctggacaccc ggaccgggaa
    10081 ctactggcaa ctcaacccga ccgcggcggt ggccgccaag gtgctcgtcg acggcggcga
    10141 cccggcaggc gcggcccagc ggctggtcga ggagttcgag gtggatgatg acgtcgccgc
    10201 cgccgacgtg accgcgctgg tagacgccct gcgcgcggcc ggggtggtca ccggatgagt
    10261 gtgctcgggg cgctgcaccg cgaccagttc ccgccccgga cccgcgcgat gcggctgcgc
    10321 gcccaggtgg cggtcctgct ggccagggtg ctggcgcggc tgaaaccgca ccacctgcag
    10381 cgggtgctcg cgcgactgag ccggggcgcc cggccagcca ccttcgccca ggccatggcc
    10441 gcccgccggg tcgtgctggc cggccggatc agcctgcacg gggtgaaggc gtgcctgccg
    10501 aggtcgctgt ccgcggtgct gctgtgccgg gcctacggag tctggcccac ctggtgcgtc
    10561 ggcgtgggag cccggccgcc tttcggcgcc catgcctgga tcgaagtggg tgaaaaactc
    10621 gtcggcgaac cgggcgaaca ccgggattgg gttcgactga tcaccgtgcc gccattgtcg
    10681 gaaccagcgt gaatgcgtac ggttcgaaac agccaacacg ggccaccgat gttgtgcgac
    10741 accaatcagg cacataccag ttggagggtt cggcatgtcg aagaagtccc tgtacgaaac
    10801 gccggtaatt ctttttgtcg gttccttcgc agcggtgacc ggtttccgtc cgtccgggtt
    10861 cttcgacggg atcgtcgtgg gcggcaagtt ctgacccacc cggaccgtct cgtgccgggc
    10921 cgaggacacc ctcggcccgg catgtcttcc tcccggcacc agagacccca ggaagcggtg
    10981 accacgatgg agagccagga actgccgttc ttcttcgtct tccccgaccg cgaggacgcg
    11041 cgcgagcccg ccgagcgagc gcagcggcag gccaccggcg cccgcgtgct ccggcacccg
    11101 tccggccgcc cctggatcgt cggccgctgg gacgaccacg agttcctgct cgcccgcgcc
    11161 ggcagcacga tgctcgccct ggccggcacc ttcgacctcg accaggccga actgacccgg
    11221 cgcgcggcac tcacccgctc cgccgccgac ctgtgcacga ccaccagatc ctggccgggc
    11281 agcttccacc tggtggcctc cgtcgacggc gagacgctgg tgcgcggcac cgcctacggc
    11341 tcccgccggg tcttcaccac ccgcgtcggc gacgccgtgc tggccggcga ccgcgccgcg
    11401 gccctggccg ccctggtcaa cgccccggtc gaccggggcg cggtcgcgct ccgcctggtc
    11461 cagcccctgc ccgtggaact ggccgaacgc gcgatgtggc aaggaatcga ggcggtccgc
    11521 cccggcgagt acctgctcgc ccactccacc ggcggcgcca cccgcaaccg ctggcaccac
    11581 ccgcccaccc ccgacctgcc cctcgaagcc ggagctgccc gcacccggac ggccctggcc
    11641 accgcggtca gcgtgcgcac cgccggcggc ggcaccgtca gcctggacct ctccggcggc
    11701 ctcgactcca cctccctgtg cttcctggcc agccggcatg ccaacggcgc caacctcctg
    11761 gcctgcaccc tgctgctgga cgaacgagtc aacgacgacg gcgtgtggac ccgccgcgcg
    11821 ctggagcagc tccccgacct cggccacctc atggtgccca ccgccgacgt ccccctgttc
    11881 tacgagggcg ccttcgaccc gcgcgaccgc tgggacttcc cctcccggat caccctgtcc
    11941 cgccgccgcg ccgtggtcgc ccagaccctg atggccgcca agggcagccg cctgcacctc
    12001 accggcaacg gcggcgacca cctcttcttc ggcgccccca accacttcca cgccaccgcc
    12061 ctccgccacc ccctgctgac cctgtcccgc ctccgcggct accgggccct ggattcctgg
    12121 cgctggcgcg cggtcctggc ccaactcacc gaccgccgcg gctaccgcgc ctggctggcc
    12181 ggcctgaccg tgcgcgactc cacccccatg gcccccgaca cgccaagact ccgctggacc
    12241 gcaccactac aggtgcccag ctggcttacc cccgactgcc tggacctgat cgacaccgaa
    12301 ctacaagccg ccgcccgcac cgcccacccc ctggccagca cccccggcac ccacgccgaa
    12361 ctcgccgaca tccgctccag caccgaggac atgcgagccc tggacgacat ctcccgcctg
    12421 gccggcgtcc ccaccaccca cccctacttc gacgaccacg tggtcgacgc cgccctgtcc
    12481 gtccggatcg aggaccgcgt caccccctgg cgctaccgcc cactgcaggt agcggccctc
    12541 cgcggcatcg tcccgccccg ctccctgtcc cgcgccacca aggcagaggc cacccaggac
    12601 gccgaactgg gcctcatccg ccaccgcgaa gaactcgtcg ccctctggac caacgccgcc
    12661 ctgggccacc agggcctggt cgacgccaac gccgtccgcc gcatcgtcac ctccccaacc
    12721 tcccccgaac tccgcgacca gggcctgatg accaccctga tgaccgaaac ctggctccgc
    12781 tcggccacca cctcggcctg gtgacgacaa cggcgatgcc ccaggctgac cgctagctgt
    12841 cacccagaac acggccgcca cgacccaccg cacactggcg cggtggcacc tgcgagagaa
    12901 aacaacaggc tgaccgcgct gctgttcgtc gcagcgctgg ccggtggctg cgcagcggag
    12961 ggcccggccg cgacctcagc gcccacctcg aacagcccca ccacgacagt gccggtctca
    13021 cccacgacga gcccgccgcc gacgtccgaa tggaccccac cgccgccgcc tccaccatcg
    13081 cccctaccgt cggtcgagct gccgacgaac gacccgcgtg cctgcacgga cggcgattgc
    13141 gtgctccgga tcaagcggaa catgaccatc aacgtgggcg cgggccgacc cgtcttcaag
    13201 gtgacgaaga tcggcaaggg cggggtcgac ttctccctgt cctaccccac cggcacccgg
    13261 gccaccctca ccctggacaa ggtcggcgcc ttcgccctgt tcggcgagtt caagatcacc
    13321 cagtccgagt gggacggcaa cgggctggcg gaggtcgaag tcgccaccaa atgaggcggc
    13381 acttccccgt gtccgccgca catgtcacgg acaaacgacc gagggcctga ccatcacaag
    13441 gatgatcagg ccctcgacat gtacaaaacc gtcgggacga caggatttga acctgcgacc
    13501 ccttgacccc cagtcgtgga acgactgagc gacatgctcc ggcctgttct tcgaggtcag
    13561 cctccagtgt aactggccga gtaaaggagt ctatggtttg caaggctggc cgtgacgacc
    13621 agacaacccc ggcccatcaa cgcaatgatt gtgtaatgcg ccttcccttg gtccgggtcg
    13681 ggatgtgcag gtgcagtgga ctgccctccg cggcgaaggc cagcgcggcc agctacccag
    13741 gtccgtggcc accaggatcc agcatgcgca gccgttcgtg aaggtctgcg gcccggtagt
    13801 cctcgaagtc ctcgtagatg gctaatgcct cccgccagca ggcaatcgcc cgcgtggtgt
    13861 caccggtatg gcccaacgag actcccaacg tgtcaagcac tccggctctg cccaacagga
    13921 agaatctctc ggtgttgctc agggcctgct cgcatacagc gatcgcttgc tggtgtctgc
    13981 ctagaccctg gcaagcgcgt gccaactgtt ccagtgacca agcttcgcct atgttgtcac
    14041 ctgcgtgtcg ccggagcatt acgccgcgtt ccgcgtgagg tagtgcctgc tcgaagtcgc
    14101 ccagccctgc cagcgccgcg ctgatctgac actcgatcac cccctccaat cggccatgct
    14161 gggctccggg gcacagcggc agagcctccc acaagtggcc gagagcatcg gcgtgtcgcc
    14221 cctgcttgtt gcaccacgat ccaaggtcga gcagggagca cgcttcccgc catggatcgc
    14281 ccagctcccg tgccagcgcc agcgcatccc agtacacgtc gagggcctca tcccaacggc
    14341 ccaggtgtgc caggtgctcg cctgtcatct ggagcacggt gcattcggtg attcggtcac
    14401 cgatacgccg cgccagcatc ccacacagct ggagaagctc ccgcgcctcg ccaaagcgtg
    14461 ctctgtaaag cgaaaaccag gagacagcgg tccagaggag gagggcgagt tcgaccggat
    14521 tgcgttcagt cgcgcgccga gctgcggcga ccaggttgtc ccactctgcc cgcacccagt
    14581 tccaagcctc agccgggtcc gtgaacacga cctctgggta agccgaggtc ggtatttcca
    14641 aaggtggata ccaagaggag tgcgccggag aggcgacctg gagggcggcc ttggcgtggt
    14701 gggcgtacca ctccagcacg acctggtgca gccgggtttg gtcgtcgggg tgatcttcgg
    14761 tgtcggcgag ttcactggcg taggcgcgca gcaggtcgtg gaagcggtaa cggtctcggg
    14821 cggtctgctg caccaggtgg gcctgggtga gtgaggtcag cagccgccgg gctcggtcga
    14881 gctcggtccc ggcaatggcg gccgacgcgg ccaggctgaa ctccggccca gggtgtagcc
    14941 cgaggcggcg gaacaggcgg gcgtgattgt cggtgaggcg ctggtaggac caggcgaaca
    15001 cggcgcggac ggccagggtg gggtcgtcgg tgtcggtcag caggtccagg cggtgccggg
    15061 cgtcggccat ctcagcggcc agctcactga gagtggtgtg cgagtaggcc aaggcgtgcc
    15121 cggcggccag gcgcagtgcc agaggcaggc gggcgcagta atggatcagt gtggcggtgg
    15181 cctcgggctc ggcggccagg cgggctgggc cgaggagtgt gtgcaggagt tggtgggctt
    15241 cggcgggggt gagtaggtcc agggtgaggc gggtggcgga gtggccgatg accaggcccg
    15301 tgaggctggc ccggctggtg atgagaacga ggcagccggc ggtgccgggg agcagttggc
    15361 ggacctggtc ggtggagctg gcgttgtcca gcacgatcag cacccggcgt ccggccagga
    15421 ttgagcggta gaggccggtc tgggcgtgga ggctgggcgg caggttctca gggggtacgc
    15481 cgagggcgtg caggaaggcg ggcaggacct cgtcggtggt ggcgggggta gtggggtcgt
    15541 agccgcggag gttgacgaag agggtgccgt cggggaaatg gtgctggacg cggtgggccc
    15601 agtgcacggc cagcgtggtc ttgccgaccc cggcggtgcc atccacggcc gagatcacca
    15661 ccgtgccttc ggcgtagcca ccactggtgg ggagaagggc gtcgagcgtg gccaggtgct
    15721 cggcacggcc ggtgaacccg gccgcggcca ggggcagttg ccggggaacg acagggggtt
    15781 gcccaggctg gtagaaggtg aggtggtgga tggcgccagc ctggaccacg gcaccgagat
    15841 cgccgccgtg cacctgattg tgggtgtccg ggccccggcc gtccatgcca tcgagtttgt
    15901 ccgcacggca cccgcggttg ggcggtgctg agccgggacc actcacatgg acgacagacc
    15961 gcccggtagg tgtgggcggt tctccagacg gatgggaacg gcgttggtga catcacgtcg
    16021 tgacattggc cccaggaaga ttgattcgtg attcgcgaat cactatggtc gtgacatgtc
    16081 tctcgccgag tgcccaccgg gtaggagggc gtcattgctg ctgttcggga accgtcacaa
    16141 gctggagctg ctcgcggcgt tggccagggc cggggacaac ggcgtcaacc tctcggatct
    16201 ggcggtgcag cagggcgtgg cggcaagcgt gtactacccg ccgatcaacg atttgctccg
    16261 cgcgggtctt gtcgacaagc ttccacagcg gttgcctgac cgtcggcgtt ggtaccgccg
    16321 cgcggagggc tccgtgtggg agcccatggg ggtgctcgcc gaagggctcg cgacgatcga
    16381 ggtgaaggca tcatgacgac cgccatggct gctgcggttc gcgctgcctc gaccacggtg
    16441 gcgggctcgg tgccgctggc ggatgcatcc cgcgtggaga ccgcggttgt ccggatgttc
    16501 ggcttcaccg tcggcttggt gtacgagccg gatgccgttg aggtgccgag gcgagccggg
    16561 tacgccgacc aaccggacgc gccgtcgatg gcgttcctgg acacgctcat gaacttgccg
    16621 gtcgaccaac ctgttgcgtt gcgagacctc accgagaggc agcggcagca cctccgcgcg
    16681 gcgcctccgt tgaccgttga ggtcgaccgc caccacgtga cacggctggc cgtggcgccg
    16741 gtcaggactc ggttcgcgct ggttgcggcg aaggactggg caactggcct caagcgggct
    16801 ggccgcttca cgccgttctg tgccaaggct ttggtgcttc gtgcgttgcc ggcggacagc
    16861 tcggatttgc tgatgagggc gtcgttctac gggactgggg tgtgcgtgtt cgacggtcac
    16921 gagctggaca tggtcgttga accgtgccgg tacgtccgca agcgtcacac cccggcgcat
    16981 tggtggttcg aggaagaggt ctacgcccgg atcagggcgt agacggccag atcggcaatc
    17041 ccgcccatgc cttaagcgga ccgggggcgt cgaatgcgtc ttcccgcccg atctcgatgt
    17101 tcaccgtgtc gcagtggtcg attgccttct ggcagcgctt ctgccaccac tccgcacgct
    17161 cgccaaggac gcgctgagca cgcatctcgg cgccccactc gttccagatg tgcacgccgt
    17221 gtgcgtgcgc ggccaaggag tcgggcttgt ccaggaaggt gtccagcttg cgtccatggc
    17281 agctgccgca ccagcacgct ggcggagttt ccaagttggc gaacctctcg gcaagcaggt
    17341 tgcccttgtg gaaggacatc agctccggga acaacacgct gggggaccgg tctttctcct
    17401 tccccttccc cgcgagcggg atctgtccga acgggacgac gtggcgcagg ctgcccccgg
    17461 tgccgatcga ggcggcgaac gcgccgtggc tcatggcgtc gaacgcggtg aggtcggtgc
    17521 gaaaaaccgc gacatgcccc gcctctgcga caaggcggcg caggttggcg accacgccct
    17581 tctttctgtc catcgggtcg tactgcccac ccagcatgat cgccttcggc accgtgaggc
    17641 gcttgaggat cgcgaggagc tgagggaagt ggtcgtggga gagccaggcg acggcgatgg
    17701 gcacgctgaa gaggaaatcg tcgcggtcca gtcgctcgac gagcctcgcc gcggccttga
    17761 gcggggctgg ttggccggca gggaggtagc ccgtcggggt catggccgcg gtcgcgccag
    17821 catccagctg tgcttggaga acatcgttga gcgataccgg gaacagaccg ccctcggtgg
    17881 gaagggcgaa cggctcgtcc tcggttgcgg cggcccgtgt gtagccttcc gggtccggca
    17941 ccagcgcgcc ctggtaccgg ttgtgccgca gcttcgtgat gcccgagttc gccttcgcgc
    18001 cgcgcaggac caggccgctg acatcggacg gcagcaggtc gagcagctgg tagccggtgt
    18061 cgaagcaggc gtggacaagc accctgtcgg tcagctcgcc gaccggtcct gccggtgcgg
    18121 cgggcttggg ggcaaggctc agcgcctgca gtgccgcagc ccgtgcatcg ggcgcgagct
    18181 gcatcgcacc ttgatgtggc tgtccgggga gtgatttctc gatcatgtgc gtacctcggc
    18241 agtgatcgtc gagatgggaa gtctggtggt gctgccgaga tagaggcagg taaattcctc
    18301 tggtcgcagc agggcggcgc gggcgaggga gtcgacgtcg ctgccatggt cgagccgcca
    18361 gtcaaccgcg gcgcgaacgg cgacgggttg ttcgggatca agactgctcg gttccgtggt
    18421 ccggtagcca agactcgcca tctggaccgc gagcgtgcgg tactgccagt cgctgatttc
    18481 gtccaacgtg tgcgcacggc gcagcaaggc ccacatcgag acgtgccact gctccttgag
    18541 cgacagcaac agcctgagat cgacggcgcc ctggaagttc gcacggatgt ccttcgccgg
    18601 catcaggagc tgggcggcga acctgttggc ctgcttctcc tggtccgggt gcgggatggt
    18661 gtgcatcacc atgtgcccca gctcgtgggc cagggtgaac ctctgccggt ctcccggcgt
    18721 ccccgcgttg agcaagacga tcgggtcctc gcccggagtg caactgctga ccgcgtccac
    18781 cggcaccgag tcgttcccgg agttcaacgg ggccggtgcg acaagagatc gagccagcac
    18841 gagtccgcca gctgcctcca ggatcgcgat gatcgagtcg atcggtccgc ccggcaagcc
    18901 ccactcggcc ctgagttcgt ccgctgcttc ttccggcgac aggtagtcgt ccacggcgat
    18961 ctgagggatc ttcgcctcga tcgagcgggg gacaccgtcg agtagcccgg ccagctgcac
    19021 gcgcgtcagg ttcaggatcg cgtggatgcg ccgcagctcc ggtgcggcca ccgcctgctg
    19081 cttgcggtgg tggatcaaac cggcgccagc cccgatctca ccgcgttcga gcgtcaagag
    19141 ttcggccggg taaccgagcg cgttcgcgta caggtccagg cggtcgccgc tgaccggcag
    19201 cttgccggac tccgctcggc tgacatatgc ctggctcacc ttcgagtcgt caccgtcgag
    19261 agccttcatc gccttcgcga cgtcaccctg cttccagcca cgtgactcgc gcgcaagcac
    19321 gagcatccgc ggttgcgcga ttgcgacgac atctgcgggc acaggctcct ccagggttgc
    19381 ctcaaaattg taccacgaga tataccgagc atgatgcgga ggtgctgccg tcgctgcgag
    19441 ggcgcgcggc tggcaccttc atggcgcctc gctcttcagt gagtcagagg cagtcgtcca
    19501 cgcgcagggt ggtggttcca gcgatgtgga ttggcgcatc accgcgacgt tcgaccactc
    19561 gccgccgcgg ccctccagct ggcggaggat gcggcggggc tcagcgttca tgtgggtcag
    19621 gccgccgccg tagagcggtg cttcgacgat gtcgcggtcg gtgcaccgcc gatcaggcgg
    19681 acgatcgcct tgttccggac cagcgtcggc tcgactcggt ttcagcggtc cgtcggtgtg
    19741 tccgtccggc tcagcgggtt gcagaagacc ggctcagccc ttgccgtcgt cgcccgggga
    19801 agcgtaccgg cgcctgtgcc gccgccgggc ctcagtcgag cgtcgagcca gcatcagcat
    19861 gtgcgccgtc ctggcgtgcc tggccatctg ctgtcgagtc tccgttggaa ggcggtggtc
    19921 gggatccacc tgctgttcga agcggtcaag gaatgcctgg atgccccgcg atgtccgagc
    19981 ggttcggtcg ctcgtccttg cccatgaggc gtgggcggcc tgccgggcgc gaaggctccg
    20041 ctgctcagac gtcatgccgc gacggggtcc ggctggctgc tgacgttctc cgtttgccgc
    20101 ccggtcagac attctcgccg atccccatac gcaactgggt ttcttgggct cgttcggcag
    20161 cggcgctagc gccgtagtgc cgcggcatgt cctccgagtt ccacccgagc aggagcatca
    20221 gatcgccggt gtcgccgccg gcgagtttcc actcgtgggc gaagttgtga cgccaccggt
    20281 gggcatgtac tcgttggagc ccggcagcag cgccgcgccg cctcagcatg atcttgatgc
    20341 cgttcggggc gagtgcgcga cgaccgcgtt cggccagcca aaggttcggg aggttcgcgc
    20401 cgacatggtt gtcccgcagg cgcaggtagc ggctgatggc tcgcgcggtc ttcgggccga
    20461 accgcacgcg gcgctccttg tcgcctttgc cgtggtaccg cacggagtcg agtttgagat
    20521 cgatgtcctc ggtgagcagt cgaccgactt cggacagccg cgctccggtg ttgtagtaaa
    20581 gcctgatgat cgcctcgtcg cgaacgtgga tgaacgcctt gggcttgcag gtcgcgagga
    20641 ccaacttggt gtcgtcgtcc cggatgaccg gcacgagcct cttcgtggtt ttgggctgcc
    20701 gcacccgctc catcggcgag cggtcgatct cctcctcatc gaacagcaac cacttgaaga
    20761 actgcttcag tcccttgtgc ttgttcaagg cggtggccgg cgagcgggtc ttgatcatcc
    20821 aagcctggaa cgcctccacg tgctccttgc gcactgcggt cgggtcctcg gcggcatcgt
    20881 gtgcttcaac ttcggcagcg tattcggcca ggtatcgagc cagctgaacc gcagccagca
    20941 ggtagttgta gcgcgtggtc gccgggtagt tcccggcccg cagtgtgcgg tcccagtccc
    21001 gcaggaagct ggcccacatc ttcggcagcg aggcagccag tcgttcaagc tcagtgccca
    21061 tgggctactc gcaggatgcg accaggttgg caagaagccg tccggaggcc acctgccgcg
    21121 gcccccggaa tgcctgggcg gaagtccagg ggagaggtac tgcaccggtg ccgacgcgca
    21181 gcgcgcactg ctgcgttcca tcggcggtaa gtggtgcgcc agctgcactc acggcagcgc
    21241 tgctggatga tcatgtcgcc catttccgat ccgggtccgg ttcggaggtg agcagtcgtc
    21301 ccgacagcgc ggtggctggc gcgggctgcc acccggtgat cgcgttgttg gcgaggctgt
    21361 ccgggaagac aggtgcctgg aagatcacca cgtcgtagtg ggcggtgagg gcgaccggca
    21421 ctccgcctgc gcatgctcgg gcagcagctt ggcgttcggc gaatccggca cgggtgatca
    21481 ctcggtgtcc gcggaccctc gcggtgaggg caatgccgcg ctgcattggc acgaacccga
    21541 cggcgcttcc cgcctccagc actctggcag gcaggtcgag cagggcgccc ccgtatcgaa
    21601 ctggacggat gatgaccacg atgcgtccgc cggcgcgaag gagcgggcgg cagaacgaca
    21661 gtccctcggc gagccgttcg cagtcggtgt ccggcactga ctcggtcggc gtgcggtcgg
    21721 tcattcggaa gccggtcaac acgaggtcga cctggccggc gaggccggtt gcctcagcgt
    21781 cgcggaggag gctggcgtct ccggtgatca cggttccggg ccgttgagca ccgttgcggc
    21841 gggctgcggt gatgttccta cgcgccactc gtcgccatcg cgggttagag gtgaggccga
    21901 tggcacggcg gtcggcgtag agggcttcgg ttggcacggt gcctgcaccg cagtcggggt
    21961 ccaggaccag gtcgccgggg cggctgaggg cggcgatggc gtgtgcggcg atcttgggcg
    22021 ggacctgttc gtgatcgaac tgggtggctg gggtgtagcc gccgcagcgg agttggtcgg
    22081 ccagggtgcg ttcgccggtc atccacaccg acgagggacc cgagttcggc gagtggccgg
    22141 tcatcggagg tctccgcgat tcgccggagc aacctcaccg gatggggcgg cggtgaagac
    22201 gaggagatcg gcgaaggact gctcaccagc gaggccgtcc tcgccgccat cagagcgggg
    22261 ctggcagaca ggctctcgga gcagggccag gtgatcgagg tagcagagtc cggactcccg
    22321 aacggtccgg actacggtgc cggtcggatc gcggaatcca ctggcagtcc ggtcgctgtg
    22381 tgtgatgacc gcgagggtgc cgcggcgcgt gaggcgggag ggccagtagc gcagttcggg
    22441 atggtccgag gcggaggact cgaccgcgat gatgatcagg tcgaaggagt ccagacccgg
    22501 actggtaatt gcatcggctg gctggtccgg actcacctcg ccgtcgccaa ggcgactcgg
    22561 ggcggccggc aggagtccgg gtccggactc ggactcggcg tgcggtggcg agctgtcgcc
    22621 cggatgcgcc gcggcttgcc cctcggcccg gacctggaca gtccggccga gccggaagac
    22681 ggcccagcgt gcttcgagga agcagtcgta ctcgcggtgc ctggacggcg tccggacctc
    22741 cgggccgatg ctcgccagcg gtagtccgga gcacgatggc gcgagcagca gcacccgctg
    22801 gccg
//
