LOCUS       NZ_JALMDK010000007     24346 bp    DNA     linear   CON 13-SEP-2024
DEFINITION  Crossiella sp. S99.2 NODE_7_length_539781_cov_101.243615, whole
            genome shotgun sequence.
ACCESSION   NZ_JALMDK010000007
VERSION     NZ_JALMDK010000007.1
KEYWORDS    WGS; RefSeq.
SOURCE      Crossiella sp. S99.2
  ORGANISM  Crossiella sp. S99.2
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Crossiella.
REFERENCE   1  (bases 1 to 539781)
  AUTHORS   Gonzalez-Pimentel,J.L.
  TITLE     From North to South: A Spanish map of bacteria producing bioactive
            compounds in show caves
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 539781)
  AUTHORS   Gonzalez-Pimentel,J.L.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-APR-2022) Agroquimica, Microbiologia Ambiental y
            Conservacion de Suelos, Instituto de Recursos Naturales y
            Agrobiologia, Av. Reina Mercedes 10, Sevilla 41012, Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2021
            Assembly Method                   :: SPAdes v. 3.14.1
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 200x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023094165.1-RS_2024_09_13
            Annotation Date                   :: 09/13/2024 06:26:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,481
            CDSs (total)                      :: 9,422
            Genes (coding)                    :: 9,365
            CDSs (with protein)               :: 9,365
            Genes (RNA)                       :: 59
            rRNAs                             :: 2, 1 (5S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 1 (5S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 8 of 57
            Pseudo Genes (incomplete)         :: 50 of 57
            Pseudo Genes (internal stop)      :: 4 of 57
            Pseudo Genes (multiple problems)  :: 4 of 57
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:32:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 358657
            Orig. end                         :: 383003
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JALMDK010000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24346
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="3"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24346
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24346
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14346](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14346
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            160..1128
                     /locus_tag="MZC64_RS28140"
                     /old_locus_tag="MZC64_28155"
     CDS             160..1128
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102291.1"
                     /locus_tag="MZC64_RS28140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28155"
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_247761743.1"
                     /transl_table=11
                     /translation="MINGDRELAQRVQERLGKRHPVFAVATVKSGEISVAGVGAELTAD
                     FEIGSISKGVTGLLYADALAREQIASATTLGDLLPLGQAPAAALTLAAVSTHHSGLPRL
                     APTGSLLRKTIALWRHGANPYGETLAELLTCLDRVQPGKPRFRYSNLGYELLGHALARA
                     ARTSYPDLLRQRITEPLGLHHFYLPETPYQIRSGAVPGRSKSGRPREPWTGEAVGPAGG
                     IRASIQDMATLTAALLDGSAPGIAALDPVTDLAGPRVRIGAAWLTQLHQGREITWHNGG
                     TGGFRTWLGLDRAASTGAVLLSATTAPVDRPGFSLLAKLST"
     gene            complement(1266..1862)
                     /locus_tag="MZC64_RS28145"
                     /old_locus_tag="MZC64_28160"
     CDS             complement(1266..1862)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015658.5"
                     /locus_tag="MZC64_RS28145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28160"
                     /product="DUF305 domain-containing protein"
                     /protein_id="WP_247761742.1"
                     /transl_table=11
                     /translation="MNRATLVPILLGALVFAGCASPGPGPTAPPSSSNRVAASTTAGAD
                     FNDADVMFLQMMIPHHGQAVEIARLAKTKATRKEIRDLAAAVEATQVSEAESMTAWLRA
                     WGKPTEADTDPNAHAHHGGMPATSKDVINALAKGGPTFDRDAVNVLTGHQHGAVEMART
                     ELKDGRNPQAKQLADRIVQSRTAQIQQLLTLLGQS"
     gene            complement(1927..2658)
                     /locus_tag="MZC64_RS28150"
                     /old_locus_tag="MZC64_28165"
     CDS             complement(1927..2658)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020642349.1"
                     /locus_tag="MZC64_RS28150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28165"
                     /product="lytic polysaccharide monooxygenase"
                     /protein_id="WP_247761741.1"
                     /transl_table=11
                     /translation="MKLRRFLAMATAAIGITPFLLVVLPASSAFAHGYISSPPSRQAQC
                     AQGTVPCGPIKYEPQSVEGPKGLRSCSGGNAPFADLDDDGKGWKATSVGNTVNFTWTFT
                     ARHRTRDYEYYLNGQRIALVDGGNVQPPPTVSHTVNLGGATGRQKLLAIWNIGDTPMAF
                     YACVDLQIGGGGTPTTSPTTKTTTPTTTATPPPGGTWAANTAYQVGSQVTYNGSTYRCT
                     LAHTALPGWEPPNTPALWQQV"
     misc_feature    2881..2894
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.03"
                     /tool="antismash"
     misc_feature    complement(2882..2895)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.34"
                     /tool="antismash"
     misc_feature    2895..2910
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.59"
                     /tool="antismash"
     gene            complement(2971..3732)
                     /locus_tag="MZC64_RS28155"
                     /old_locus_tag="MZC64_28170"
     CDS             complement(2971..3732)
                     /NRPS_PKS="Domain: PKS_KR (5-180). E-value: 4.6e-11. Score:
                     34.9. Matches aSDomain:
                     nrpspksdomains_MZC64_RS28155_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020672361.1"
                     /locus_tag="MZC64_RS28155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28170"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_247761740.1"
                     /transl_table=11
                     /translation="MQANDVALVTGANKGIGREIVRQLALQGYTVYLGARDAERGQAAV
                     AELVAQQGESGGDIRVVRLDVTDADSVRAAVDRIEDQVGRLDVLVNNAGIVVEWGVRTE
                     QVTAAQLREVFEVNVFGVVTVTAACVPLLRRSGNPRIVNMSSGLGSLGLLSDPASPFSA
                     KDLLAYSASKAALNALTLGYADALRADGFKVNATSPGLVRTDGNAAATFPRGDRGPAEG
                     AVVPVGLATLPADGPTGVFRGPEALDQTIPW"
     aSDomain        complement(3193..3717)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MZC64_RS28155_PKS_KR.1"
                     /evalue="4.60E-11"
                     /label="MZC64_RS28155_PKS_KR.1"
                     /locus_tag="MZC64_RS28155"
                     /protein_end="180"
                     /protein_start="5"
                     /score="34.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGANKGIGREIVRQLALQGYTVYLGARDAERGQAAVAELVA
                     QQGESGGDIRVVRLDVTDADSVRAAVDRIEDQVGRLDVLVNNAGIVVEWGVRTEQVTAA
                     QLREVFEVNVFGVVTVTAACVPLLRRSGNPRIVNMSSGLGSLGLLSDPASPFSAKDLLA
                     YSASKAALNALT"
     CDS_motif       complement(3649..3711)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MZC64_RS28155_0001"
                     /evalue="1.00E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="MZC64_RS28155"
                     /protein_end="28"
                     /protein_start="7"
                     /score="15.0"
                     /tool="antismash"
                     /translation="LVTGANKGIGREIVRQLALQG"
     gene            3803..4684
                     /locus_tag="MZC64_RS28160"
                     /old_locus_tag="MZC64_28175"
     CDS             3803..4684
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004559181.1"
                     /locus_tag="MZC64_RS28160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28175"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_247761739.1"
                     /transl_table=11
                     /translation="MPDPEIRELRYFHAVAEDRNITRAAARLGIAQPPLSRAMRQLERR
                     LGVALFDRTGPRLTLTEAGETLLKEATVVLGALDAAVRRTRRAAQSGRGLVVTVYPGVA
                     TELLHQLKARFHADPAAPEIEILLSEFGAQADLIRDGRADVAIASCVNTRGLDTEPLHT
                     EPRVAALPASHPLAQRATLTTADLATEPAPRWRDSATIDRDYWLGNPDRPVDGPLVRDS
                     AQLLEVIALGQAVALVPASLAARNVRPDVIYRPVLDAAPYRTLLLWPEGSRSPWVARFV
                     RTALELAAARDV"
     gene            5067..6407
                     /locus_tag="MZC64_RS28165"
                     /old_locus_tag="MZC64_28180"
     CDS             5067..6407
                     /EC_number="3.1.1.-"
                     /GO_process="GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016994.5"
                     /locus_tag="MZC64_RS28165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28180"
                     /product="erythromycin esterase family protein"
                     /protein_id="WP_247761738.1"
                     /transl_table=11
                     /translation="MSREPQADQLRTTLANHTIPLHSTNPGHALDDLTPLTAALDGVRV
                     VGLGEATHGTREFFTLKHRLVEFLVTRLSFTVFAIEAGWSSCRAVDDYVVHGTGSAAEV
                     LAKLGYWTWDTEEVLALIEWLRAHNADLPLDQRVRFRGVDPVLERAGTEAIAGYLDTVD
                     SARATTFRGAVKALRAEFSKLSVGRIISEAFRQLWRKIPGVRPGAAQSEVLAARAVVAD
                     TVAWLAAHPADNDGWREAEWHAWAVDRAAEIRTLPTLGQAGGHLRDRTMAEALRRILAE
                     PGARAMVWAHNGHLAAATRSSKEAALGAELRDWLGDGYYALALVTNQGGFQAMKLGTSE
                     LAEFELDPAESGTLEWQLAQAGGDHLLDLRAAGADPVLRAWLDGKQRMRAYGSVIGFWP
                     ALKKETVSVRLGAEFDGIAYLDRTTRARPRTDAADRKSGADSRRGGV"
     gene            6415..7281
                     /locus_tag="MZC64_RS28170"
                     /old_locus_tag="MZC64_28185"
     CDS             6415..7281
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020666224.1"
                     /locus_tag="MZC64_RS28170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28185"
                     /product="N-acetyltransferase"
                     /protein_id="WP_247761737.1"
                     /transl_table=11
                     /translation="MAIVMGTPDVDGLSAAVHALQDWQYDGAPMQLHPGDVGWYWRLGA
                     EATAAAVRTWRRAGRLLAVGLLDGPDLLRLTIEPAARQDEELARQLVADLTDPARGVLP
                     AGAVCLEAPTAPLVKDLLAADGWRADEPWTPLRRDLTEPVPDPGVRIEVIGPERAHVQA
                     AVLRSAFGTSKFTDERWHAMAAGLPYADARCLVAHDEQGNAVAAVTVWSAGPGKPGVLE
                     PMGVHRDHRGHGHGTAISLAAAAALRELGSSSALVCTPTTNAGAVATYRSAGFQPLPER
                     LDQRRDA"
     gene            complement(7414..9276)
                     /locus_tag="MZC64_RS28175"
                     /old_locus_tag="MZC64_28190"
     CDS             complement(7414..9276)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.5"
                     /locus_tag="MZC64_RS28175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28190"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_247761736.1"
                     /transl_table=11
                     /translation="MPERDNRLYCEVLGALAARRGPVDIELGWSRQQAVLAVLLTRMNQ
                     PVPVEALVEAVWADSPPQGARNTVQTNISRLRRALRPAGATHDRDSVVLRTDAGYLLRG
                     APDQLDALVFEQELDAAQEHQRAGRLAAATESVSSALGRWRGEPFSGLDSPYLHAHRLR
                     LRESRLLAQELSAALSLDRGEHRSVVAELTALVTRNPLRERLRELLMLALYRSGRQAEA
                     LGVFQEARTALADQLGIDPGPALRGLHQRILTRDPELSAPPRRACPPVVITPAVAVEQL
                     PADPLSFTGRDAELRRLTGSAAAAEIHVLDGMPGIGKTTLAVRAARLLAPDYPDGTIFL
                     RLNAFAAGQEPLSAHAALGGLLDAAGLPAAAMPDTEHGRAALWRESLRDKRMLLVLDDA
                     AGHEQVRPLLPGPGRCRVLITSRRRLSALEGVRSLELNPLPLEQAARLFQHLTGPREQP
                     ADPAATRQLVSLCGGLPLAITLLAGRVRHHPRWTDRYLADLLSSARTRLSELHAENVTL
                     TAAFDRSYRGLPAEGRRLFRCLGLSAGVEVDLPTTSVLAGLTAAETRHGLERLYDNHLL
                     TESAPGRYLLHDLIKEYARTLAELEDPTLEAEFHRSPGLTQRAG"
     misc_feature    complement(8785..8787)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9492..9671
                     /locus_tag="MZC64_RS28180"
                     /old_locus_tag="MZC64_28195"
     CDS             9492..9671
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038155.1"
                     /locus_tag="MZC64_RS28180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28195"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_221490130.1"
                     /transl_table=11
                     /translation="MDAFDLDARVSTPAAANGQAQPLSITSVITRLACTRTPLCSRFTC
                     QCTQGACTAGCPKR"
     CDS_motif       9492..9560
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MDAFDLDARVSTPAAANGQAQPL"
                     /locus_tag="MZC64_RS28180_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9561..9671
                     /prepeptide="core"
                     /locus_tag="MZC64_RS28180_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="2.70"
                     /molecular_weight="3655.3"
                     /monoisotopic_mass="3652.8"
                     /core_sequence="SITSVITRLACTRTPLCSRFTCQCTQGACTAGCPKR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MDAFDLDARVSTPAAANGQAQPL"
                     /leader_location="[9491:9560](+)"
                     /alternative_weights="3673.3"
                     /alternative_weights="3691.3"
                     /alternative_weights="3709.4"
                     /alternative_weights="3727.4"
     gene            10001..11197
                     /locus_tag="MZC64_RS28185"
                     /old_locus_tag="MZC64_28200"
     CDS             10001..11197
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="MZC64_RS28185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28200"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_282105984.1"
                     /sec_met_domain="LANC_like (E-value: 3.3e-44, bitscore:
                     145.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEWYFPSFGYGHAGIALLHVHASAAAPNAVESARSLSAGFAFIRE
                     AVAGTQAQPLLAPGVFSGTGGLALCVAGCAEAEPRFAPSLGRLHDQFAAQIADLDLPMV
                     ERAVSDSDYDMISGAAGTLAYLCSIAEPDQALHPAADKLLDYLIWLSAPPRDLTLTRRW
                     LIAPELCAPLGRDPREFPGGYLNLGMAHGIPGAVAALAVAWQRGLRRPGQEEAIRRMTD
                     WLLAVRRADPHGPVWATEIPVAATGEEVRPNQPHDQIAWCYGTAGVAVSLLAVADALGD
                     DQLRTAAIEAFEGVLRRSVAEPVLSPTFCHGVAGLLAICLEFATAGSDLAREHTPRLLT
                     ELLGHADPANPLVFRDEEEPGVFVDSPALLTGSTGVALTLLAAVSPVRPSWLTAFLVR"
     misc_feature    complement(10002..10016)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.31"
                     /tool="antismash"
     misc_feature    10049..10051
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11200..14346
                     /locus_tag="MZC64_RS28190"
                     /old_locus_tag="MZC64_28205"
     CDS             11200..14346
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="MZC64_RS28190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28205"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_247761734.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.2e-162,
                     bitscore: 536.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.9e-12,
                     bitscore: 42.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.7e-33, bitscore:
                     109.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGPRYEPADFFLLRAPALPAGVYQDLLATTTDNPDQARAEVRQR
                     LYALAAQPAVRRALTVASGDLVDALDRAESSATTDKRTRRLHSRLLRYLIRMTTRPTPF
                     GAFSGVAVGEFGPETTACLGESALRDNRIRADMAWLLTLIKQLESDEQLRPHLRVVLNS
                     SVHRSGDRLVLPYADIYGHNDNRAVRVRATTAALAVTRLAATPIPLAQLLAGLAEEFPG
                     VDPARVSGLVEELRTLNFLTSDLRPPLTVAQPEAQLAKQLAGIEAAGEIAESLREVINL
                     AHRAATEPEPAALAELTAAQRALTPEHTGPTYQLDATLDLPRTRLSGAVGEAVAEAVDC
                     LMRLSAALPGHNHHLAQYRDAFTERYGLLALVPVLELLSPEHGLDAPPTYTEPPRGYPL
                     PHNVQEPWQQDFDRVLTEFAVQAWCAGEHEIELTDEWLHRFAPLEDAPPLALYPALDVF
                     AQISTDRSVDSGAWRAVLRQEGLAFGGRTSGRFFDLLGEDAVDRLRGYARREEELSPEV
                     VYAELCYLPNHGRAANVALRPLLRGYEVPVNTTPSVPPDRVIDLADLCVGANEDRFFLW
                     SKRLGKQVVVSQNHMLSPHVAPNVARFVLEVSNDGYAMPCGFRWGPLETMPFLPRVTRG
                     KVVLRPAQWTLNALPGKDFPAEVRAWRDRWKVPRHVYLVEADNRLLLDLEHPMCLDELA
                     TECNRGPEPVTLHEMLPAFDQQWLRDADGAAYLEEIVVPLIAKNSADTARSEVTLTAPT
                     GNAPEIIRQHLPGGQWTFLKLYAGITQQDEVIATRLRELVAMLREQGLIDRWFYIRYMD
                     PRPHLRLRFRAADLEVAPQLLWYLTIWSGQLAEEGLAFDTAIAGYTPEIERYGGPPVFD
                     TVEPLFAANSEVTAELVALLHNDKDGIRPEFAAIAAVDTLYRQWGLTPRERMELLPGSG
                     GADAEAARTEFQQQRAYLTELLVPWDYRPHELGRDHHRLISEILAPQQESVEAAAHAVR
                     VAAAEGVLWGAESSVLGSLAHMQINRLLPIDLRRESHLYAVWRHTLRAIGGRPAPEARA
                     "
     aSDomain        11674..11943
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_MZC64_RS28190_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.40E-13"
                     /identifier="RREFam001.1"
                     /label="MZC64_RS28190"
                     /locus_tag="MZC64_RS28190"
                     /protein_end="248"
                     /protein_start="158"
                     /score="42.3"
                     /tool="antismash"
                     /translation="VVLNSSVHRSGDRLVLPYADIYGHNDNRAVRVRATTAALAVTRLA
                     ATPIPLAQLLAGLAEEFPGVDPARVSGLVEELRTLNFLTSDLRPP"
     gene            14343..16139
                     /locus_tag="MZC64_RS28195"
                     /old_locus_tag="MZC64_28210"
     CDS             14343..16139
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="MZC64_RS28195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28210"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_247761733.1"
                     /transl_table=11
                     /translation="MTTKNHWLRIAKMLWDLSPLRVLALILVTVAVSVVPAVQLQLTAS
                     AVQTVADAITAGGVGEHGSAVLAVGLLILAVSVMAHLLGVWHGYLDSVLRLHLSTAVGE
                     EVMRKGTRMDLQDYESADSYDKLQRAFQESSGSRIHQLFTDTLGFARELITILSVSAVL
                     FSWNFWVAVLILLSPIPSAIAQMWYGKKMYEIEYGRAADRRRLFYLQYLTTTDHSFKEV
                     RLFQLGDHLIGAYRDQVRRFLKVDRDLTRRQSVSLGVFGLLSVLISAGALVFAMLSTME
                     TGRLGELAGYLQAIGIVQASGHSLLVGVANLFENKLFVSNLFELFDLPERQIRGGNRKF
                     PAKLRQGIEFREVSFTYPGTEDQVLDRVSFTLPAGNCVALVGQNGAGKTTLVKLLTRLY
                     EPTGGQILLEGVPIEEYDLEELRRNLGVIFQDYIKYELPVRDNIGFGQIEHRADTARVR
                     RAAEASGADSIVDTLSDGYDAMLGRHFENGSQLSGGQWQKVALARAFMRAAPIVVLDEP
                     TASIDAEAETEIFQRFRSIADRSTSLLVAHRFSTVRIADKIIVIEGGRLVEQGTHAELM
                     RLGGHYAYLFNLQAAGYQPEHT"
     gene            16136..17131
                     /locus_tag="MZC64_RS28200"
                     /old_locus_tag="MZC64_28215"
     CDS             16136..17131
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012517.5"
                     /locus_tag="MZC64_RS28200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28215"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_247761732.1"
                     /transl_table=11
                     /translation="MKTSIFVPVMPASPADLTPYAELVRDTAAHRLWQGQSLGLETHQG
                     FAYLAGAGLTVPVGTSVTLTALRHPYEAALHARSLAALTGHSPVLGIGAGAPELVESLH
                     GKPYPSPLTAIADYLTILRGLLAGEVVNHQGREYRMHGALPPLDHPPVELGLGVLRPAA
                     ARLAGELADAAITWMTPPDYLRTVLRPELEAGAAKAGRPVPRIVAVVHVAIRRYGRDPH
                     LVALNAAREHLSAPHYIDMLRRAGLRVHPAQPGLSARALVDADVVLTGSAREIATGLQR
                     YREAGVDEIVLNTAGVRMTEDRDAALRDLTDLLAQVITPESRQPAPVGHP"
     gene            17142..17564
                     /locus_tag="MZC64_RS28205"
                     /old_locus_tag="MZC64_28220"
     CDS             17142..17564
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020674252.1"
                     /locus_tag="MZC64_RS28205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28220"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_247761731.1"
                     /transl_table=11
                     /translation="MSAEIVRQAWQTFSTRDRDRIAAVFTPDAEWLAPAGNATARALDI
                     TNHMVGREQIAHFLAVDFPRLFTSDIGVTFRGFHAVGDTVIVEETMTATLADGSHYAND
                     YCLVFEVHNGLIHRVREYLDTARGARQLHAVAPLPK"
     misc_feature    17553..17555
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(17612..17621)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.29"
                     /tool="antismash"
     gene            17737..18201
                     /locus_tag="MZC64_RS28210"
                     /old_locus_tag="MZC64_28225"
     CDS             17737..18201
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MZC64_RS28210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MZC64_28225"
                     /product="hypothetical protein"
                     /protein_id="WP_247761730.1"
                     /transl_table=11
                     /translation="MSSTRLALLALTLGGALLAAGCGGGAPAAPANCDQQQSAVAAAEK
                     ANTEADTAAKTAEGKLAEVNKTKDTANAEADKASEKAKELHEKAKKGGAAQAADSAEAA
                     AKSADLMAKATGLIVEAMEAREKAEAGRTKANETAKALTEAKQKLTDCRK"
     gene            18266..18754
                     /locus_tag="MZC64_RS28215"
                     /old_locus_tag="MZC64_28230"
     CDS             18266..18754
                     /EC_number="1.11.1.-"
                     /GO_function="GO:0004602 - glutathione peroxidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0043295 - glutathione binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005161949.1"
                     /locus_tag="MZC64_RS28215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28230"
                     /product="glutathione peroxidase"
                     /protein_id="WP_247761729.1"
                     /transl_table=11
                     /translation="MTLYDIPLQTLTGEPTTLGELSGKAVLIVNVASKCGLTNQYLGLE
                     AIHERYAERGFAVVGFPCNQFGGQEPGSAAEIQTFCSTSYGVTFPMMAKIDVNGPDRHP
                     LYAELVTTADAAGEAGDIQWNFEKFLLDPAGKVVARFRPTTTPEDNTVITAIEAALPA"
     gene            complement(18898..21111)
                     /locus_tag="MZC64_RS28220"
                     /old_locus_tag="MZC64_28235"
     CDS             complement(18898..21111)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157704.1"
                     /locus_tag="MZC64_RS28220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28235"
                     /product="discoidin domain-containing protein"
                     /protein_id="WP_247761728.1"
                     /transl_table=11
                     /translation="MSPASALRLRRIAVLAAALGLAPLLSPIAAPAASAAACGTENLAL
                     HRPATSSSTENGGTQPAAAVDGDAGTRWSSAFSDPQWLQLDLGGPKQLCRVTLNWETAH
                     AKAFQVQVSDDAATWRSVHTATDSAGGLQQLDVAGTGRYLRVHGTQRATGYGYSLWEVG
                     AYAVTDGSDPVLPPTDPRNPDFGPNVLVVDPRSSTVDTQNRLNAIAREQRTNQFGPQRH
                     AVLFKPGNYNADVDLRFYTQVAGLGLHPDDVNINGHVRVEADWLQQGEDPNNLGNATQN
                     FWRSAENMSVTLPPNTIERWAVAQAAPYRRMHVRGQLHLWNGHDGWASGGWISDSKIDG
                     VVVSGSQQQFMTRNTQLVDGWAGSVWNMVFVGSTGTPPPNFPNPSHTVLPTTPVIREKP
                     FLHVNAAGDYGVFVPSLRHNASGTSWASGSTAGSSISLSQFYLVKPGTPAATINAALNQ
                     GRHLLFTPGVHRIDDTIRVTRPDTVVLGLGLATVIPTTGKAAISVSDVDGVKLAGLLVD
                     AGPVNSPVLVELGEPGSSRDHAANPVSVHDLFLRVGGAGPGKATVSLRVNSHDTIIDHV
                     WAWRGDHGDGVGWTVNTGANGVVVNGADVTAYGLFAEHYQQHNVLWNGENGRTYMFQNE
                     LPYDPPDQASWMNGGTQGWAAYKVADSVNRHEGWGLGSYCYNNVNPSVVTANSFEVPRK
                     PGVRMHNLAAVSLGGVGTISNIINGVGGPANTTTQVRYLTEYP"
     gene            21265..21840
                     /locus_tag="MZC64_RS28225"
                     /old_locus_tag="MZC64_28240"
     CDS             21265..21840
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005164076.1"
                     /locus_tag="MZC64_RS28225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28240"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_247761727.1"
                     /transl_table=11
                     /translation="MDTREKLIESTRELLWERGYVGTSPKAIQERSGAGQGSMYHHFSG
                     KPELALAAITRSAEEMRERADAEFTARGTVLARITAYLRREREVLKGCPVGRLTQDPEV
                     MADPDLRRPVEETFAWVTTRLTTLLAEGVQSGELSIPDPAATATALVAVVQGGYVLARA
                     EGSAEVHARAMDGILALLAAAKNPEGKS"
     gene            21843..22238
                     /locus_tag="MZC64_RS28230"
                     /old_locus_tag="MZC64_28245"
     CDS             21843..22238
                     /GO_function="GO:0016853 - isomerase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007034286.1"
                     /locus_tag="MZC64_RS28230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28245"
                     /product="tautomerase family protein"
                     /protein_id="WP_247761726.1"
                     /transl_table=11
                     /translation="MPFVRIDALHADQSRLEALGNAVQDALVETIGVPPDDRFQVLVSH
                     DGVSSTLRYDNFLGIHKDDGIVFIAITLRAGRSAELKQALYRRIAELAQEYAGTEPRNV
                     LVNLVENELLDWSFGNGVAQYAAGIDR"
     gene            22459..23382
                     /locus_tag="MZC64_RS28235"
                     /old_locus_tag="MZC64_28250"
     CDS             22459..23382
                     /NRPS_PKS="Domain: TauD (41-295). E-value: 5.3e-63. Score:
                     205.2. Matches aSDomain:
                     nrpspksdomains_MZC64_RS28235_TauD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1121: dioxygenase, TauD/TfdA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020423344.1"
                     /locus_tag="MZC64_RS28235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_28250"
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_247761725.1"
                     /sec_met_domain="TauD (E-value: 3.3e-62, bitscore: 205.2,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTHVPILRAASTPDDGILEGSRQLRRLPEGIAERPYELFTLRPL
                     GRVIGAQIHGVDLAEPLTPLLRDEVNRALLEWKVLFFREQRITPGQQRAFAAHWGELET
                     NPFIPQGDTAEVTRFERSAAMPGLENIWHTDVTFRPNPALGSVLRLLTVPPIGGDTLWA
                     DMAAAYDNLPESVRERIEGLRAVHDYLPGFDRFTDPELLARHQEQFPPVTHPVVRRHPE
                     TGRRTLFVNQAFTTHIVGLPRAESDRLLHYLFTQAHVPEYQVRFRWQPDSVAFWDNRAT
                     QHYAVNDYHPHARVAERVAIAGDRPY"
     aSDomain        22582..23343
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MZC64_RS28235_TauD.1"
                     /evalue="5.30E-63"
                     /label="MZC64_RS28235_TauD.1"
                     /locus_tag="MZC64_RS28235"
                     /protein_end="295"
                     /protein_start="41"
                     /score="205.2"
                     /tool="antismash"
                     /translation="LRPLGRVIGAQIHGVDLAEPLTPLLRDEVNRALLEWKVLFFREQR
                     ITPGQQRAFAAHWGELETNPFIPQGDTAEVTRFERSAAMPGLENIWHTDVTFRPNPALG
                     SVLRLLTVPPIGGDTLWADMAAAYDNLPESVRERIEGLRAVHDYLPGFDRFTDPELLAR
                     HQEQFPPVTHPVVRRHPETGRRTLFVNQAFTTHIVGLPRAESDRLLHYLFTQAHVPEYQ
                     VRFRWQPDSVAFWDNRATQHYAVNDYHPHARV"
     gene            23431..24237
                     /locus_tag="MZC64_RS28240"
                     /old_locus_tag="MZC64_28255"
     CDS             23431..24237
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MZC64_RS28240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MZC64_28255"
                     /product="hypothetical protein"
                     /protein_id="WP_247761724.1"
                     /transl_table=11
                     /translation="MSGNWSTGWRRLLVIIPAVVLGGEAVALLTGLVSWRDALLLLVVL
                     EIPHIALVLGSMGYATVLAIRRRRAGEPRWTAFRRSYYQVLPTPLAWAVTRELASLVAV
                     GTLLRRPRPGIGGYSAGRGRVFAVLLVVIVVELVVLHQLIPWPGVRLAHDLVGLYSLVI
                     VVGYWAVPRTHPHRLLPDRLELRAGHDVVVTVPWPGTVVAERETRPGRAAITDDVLVLP
                     NGRGLTNLTLHLPEPATARLGRSGGLVRVIELGVEDPAGFRAAVRV"
ORIGIN
        1 ccggtggtca gcgacaagaa tccggccaac gccgggcgca cccgcccgct gtgcgaatcc
       61 ccggcctggc cacggtatcg cggcggcgac cccgatgccg cccgcagctt cgagtgcgcc
      121 cggccctaga ctggggggca cctggggagg tcgaggcgtg tgatcaacgg tgaccgggaa
      181 ctggcacagc gagtgcagga gcgactgggc aagcgacacc cagtcttcgc ggtggccact
      241 gtcaaatccg gcgagatcag cgtggccggt gtcggcgcgg agctgaccgc ggacttcgag
      301 atcggctcga tcagcaaggg cgtcaccggc ctgctctacg ccgacgccct ggcccgcgag
      361 cagatcgcct ccgccaccac cctcggtgac ctgttgccgc tcggccaggc cccggccgcc
      421 gcgctgaccc tcgccgcggt cagcacgcac cactccggcc tgccccggct ggcgcccacc
      481 ggttccctgc tgcgcaagac gatcgcgctg tggcggcacg gtgccaaccc ctacggcgaa
      541 accctggccg agctgctcac ctgcctcgac cgcgtccaac cgggcaagcc gcgcttccgc
      601 tactccaacc tcggctacga actgctcggc cacgccctgg cccgcgcggc ccggaccagc
      661 tacccggacc tgctccgcca gcgcatcacc gaaccccttg gcctgcacca cttctacctg
      721 cccgagacgc cctaccagat ccggtcggga gccgtgccgg gccgcagtaa atccggtcgt
      781 ccacgggagc cgtggaccgg cgaggcggtc ggccccgccg gcggcatccg cgcctcgatc
      841 caggacatgg caacgctgac cgccgcgctg ctggacggtt ccgcgcccgg catcgccgcg
      901 ctggacccgg tgaccgacct ggccggcccc cgggtccgca tcggcgccgc ctggctcacc
      961 cagctccacc aaggccgcga gatcacctgg cacaacggcg gcaccggcgg cttccgcacc
     1021 tggctcggcc tcgaccgagc cgcgtccacc ggcgcagtcc tcctgtcagc aaccacagcc
     1081 ccagtcgacc gccccggctt ctccttgctg gccaagctct ccacctaagc acatcgtgtt
     1141 ggccgttgtc gtacggtgtg ttggccgttc tggacggtgt cttggctgaa ctggtacgcc
     1201 agggccagca caggcgtacc agttcggcca agactgggta cgacaacggc caacacgccg
     1261 gggggttagg actggccgag cagggttagc agctgctgga tctgggcggt gcgggactgc
     1321 acgatccggt ccgccagttg tttggcctgg ggattgcgcc cgtccttgag ctcggtgcgg
     1381 gccatctcca ccgcgccgtg ctgatgtccg gtcagcacgt tgaccgcgtc ccggtcgaag
     1441 gtcggaccgc ccttggccag ggcgttgatg acgtccttgg aagtggcggg catgccgccg
     1501 tggtgggcgt gcgcgttcgg gtcggtgtcc gcctcggtcg gcttgcccca ggcccgcagc
     1561 caggcggtca tgctctccgc ctcgctgacc tgggtcgcct ccaccgccgc ggccaggtcc
     1621 cggatctcct tgcgggtggc cttggtcttg gccagccgcg cgatctccac cgcctgcccg
     1681 tggtgcggga tcatcatctg caggaacatc acgtcggcgt cgttgaagtc cgcgccagcg
     1741 gtggtggatg cggcgacccg gttcgacgac gacggcggtg cggtcgggcc gggcccgggg
     1801 ctcgcgcacc cggcgaacac caacgcgccc aacaggatcg ggacgagcgt ggcacggttc
     1861 acgatgactg cctttcctgg cgggcccgcg cccccggcgg ctggggcgcg agcctgcgtg
     1921 ccgtgatcag acctgttgcc acagggcagg ggtgttcggc ggttcccagc cgggcagcgc
     1981 ggtgtgcgcc agcgtgcagc ggtaggtcga gccgttgtag gtgacctggc tgcccacctg
     2041 gtaggcggtg ttcgccgccc aggtcccgcc gggcggcggt gtcgcggtcg tggtgggagt
     2101 ggtggtcttg gtggtcggac tggtggtggg cgtgccaccg ccgccgatct gcaggtcgac
     2161 acaggcgtag aaggccatgg gcgtgtcgcc gatgttccag atcgccagca gcttctgcct
     2221 gccggtcgcg ccacccaggt tcaccgtgtg cgagacggtc ggcggtggtt gtacgttgcc
     2281 gccgtcgacc agcgcgatcc gctggccgtt gaggtagtac tcgtagtcgc gggtgcggtg
     2341 ccgggcggtg aaggtccagg tgaagttcac cgtgttgccg accgaggtcg ccttccagcc
     2401 cttgccgtca tcgtcgaggt cggcgaacgg cgcgttgcca ccactgcaac tgcgcagtcc
     2461 cttgggcccc tccacgctct gcggttcgta cttgatcggc ccacagggca cggtgccctg
     2521 cgcgcactgg gcctgccggc tcggcgggga ggagatgtag ccgtgcgcga aggccgaact
     2581 cgcgggcagg accacgagca ggaacggggt gatgccgatg gcggccgtgg ccatcgcgag
     2641 gaaacgtctg agcttcattg ggtcagctcc cagcgtcgcg gcccgaccta caggggtgat
     2701 caggccgccg gtgcgcacaa cgccgtgtcc cgtcgcgcgc ggtcaacagg tgcctgcgcc
     2761 ggtcaaaccg gcaccgcgga acggggaacg cggacacaca cgccactcgc tccgctctcg
     2821 cgtccgcggc gacggccaag gccgattgcc gggacacgga cggcggcggc gggtccgtgc
     2881 gtcactcagt gtgacgtggt ctagaccata aatgagctgc gggttcacgt caaggaacag
     2941 cccggtcagc ccgctggacg ctggacgcgt tcaccacggg atggtctggt ccaaggcttc
     3001 cgggccgcgg aagacgccgg tgggaccgtc cgcggggagg gtggcgagcc caaccgggac
     3061 aacggcgccc tcggccggac cgcggtcgcc gcgggggaag gtcgcggcgg cgttgccgtc
     3121 ggtccgcacc aggccggggc tggtcgcgtt gaccttgaaa ccgtcggcgc gcagggcgtc
     3181 ggcgtagccc agggtcagcg cgttgagcgc ggccttggag gcgctgtagg cgagtaggtc
     3241 cttggcggag aacgggctcg ccgggtcgct gagcaggccg agcgagccga gtccgctgga
     3301 catgttgacg atccgcgggt tgccggagcg gcgcagcagc ggcacgcagg ccgcggtcac
     3361 ggtgaccacg ccgaacacgt tgacctcgaa cacctcgcgc agctgcgcgg ccgtgacctg
     3421 ctcggtccgg acaccccact cgaccacgat cccggcattg ttgaccagca catccagccg
     3481 ccccacctgg tcctcgatcc ggtccacggc cgcccggacc gagtccgcgt cggtcacatc
     3541 gagccgcacg acccggatgt ccccgcccga ttccccctgc tgtgccacca gttccgccac
     3601 cgcagcctgc ccgcgttccg catcccgggc gccgaggtac acggtgtaac cctggagcgc
     3661 gagctgccgg acgatctccc ggccgatgcc cttgttggcg ccggtcacca gcgctacgtc
     3721 attcgcctgc ataccgccca ctccagccgc ccagtcaccg gaagaccaag accgatccgg
     3781 tgccgcgcca taccctggcg gtatgcccga cccggaaatc cgcgaactgc gctacttcca
     3841 cgcggtcgcc gaggaccgca acatcacccg cgccgccgcc cgactcggca tcgcccagcc
     3901 cccgctgtcc cgggccatgc gccaactgga acgccggctc ggcgtcgcgc tcttcgaccg
     3961 caccggcccc cgcctgaccc tgaccgaagc cggcgagacc ctgctcaaag aagccaccgt
     4021 ggtgctcggc gccctggacg ccgcggtccg ccggacccgg cgcgcggccc agtccggccg
     4081 cggcctggtg gtcactgtgt acccgggtgt ggccaccgag ttgctgcacc agctcaaggc
     4141 ccggttccac gccgacccgg ccgccccgga gatcgagatc ctgctcagcg agttcggcgc
     4201 ccaggccgac ctgatccggg acggccgcgc ggacgtggcg atcgcctcct gcgtcaacac
     4261 ccgaggtttg gacaccgaac ccctgcacac cgaaccccgc gtcgccgccc tgcccgccag
     4321 tcaccccctg gcccagcgcg ccaccctgac caccgccgac ctggccaccg aaccagcacc
     4381 ccgctggcgt gactcggcca ccatcgaccg cgactactgg ctgggcaacc ccgaccgtcc
     4441 ggtcgacggc ccgctggtcc gggacagcgc gcagttgctg gaggtgatcg ccctggggca
     4501 ggcggtggcg ctggtgccgg cctcgctggc ggcgcgcaac gtccggccgg atgtgatcta
     4561 ccgcccggtg ctggacgcgg ccccgtatcg gaccctgctg ctctggccgg agggcagccg
     4621 gtcgccgtgg gtcgcccggt tcgtccgcac ggcgttggag ttggctgcgg ctcgggacgt
     4681 gtgagcacgg ttggggtgct ggggtcaagg catgcttcgc gtgcatctac cgaacggtcg
     4741 gtagatgcac gcagaatccc ggcggggctg gagcgagcgc gggcttggtg atgtcggcag
     4801 gtgctgctgc acgcgtatct accgaacggt cggtagatgg gcagaaccgc tctggcgccg
     4861 gctggcgagc accggtcgcc gccggacctc ctgagcgttc gggcactgcc tggtactggg
     4921 actgttcggc tcggtggtca cgggcgcagt cccattgccc agcggctgaa ccgcagtccc
     4981 gcaggccgcc ccagccacca gcgccgttcc ggcgagcgca ccgcgttgct gatcttcggt
     5041 accctccgat gtcatgaggt caccgaatgt cacgtgagcc ccaggccgac cagctccgca
     5101 ccaccctggc caaccacacc atccccttgc acagcaccaa ccccggccac gccctcgacg
     5161 acctgactcc cctgaccgcc gcgctcgacg gcgtccgggt cgtcggactc ggcgaggcca
     5221 cccacggcac cagggagttc ttcaccctca agcaccgcct ggtcgaattc ctggtgaccc
     5281 ggctgtcctt caccgtcttc gccatcgagg cgggctggtc ctcctgccgg gccgtggacg
     5341 actacgtggt gcacggcacc ggatccgccg ccgaggtgct ggccaagctc ggctactgga
     5401 cctgggacac cgaggaggtc ctcgcgctga tcgaatggct gcgtgcgcac aacgcggacc
     5461 tgcccctcga ccaacgcgtg cgcttccgcg gtgtcgaccc ggtgctggaa cgcgccggca
     5521 ccgaggcgat cgccgggtat ctggacacag tggacagtgc gcgggccacc accttccggg
     5581 gcgcggtcaa ggcgttgcgg gcggagttca gcaaactcag cgtcggccgg atcatcagcg
     5641 aagcgttccg gcagctctgg cggaagatcc ccggagtgcg gccgggcgcg gcccagtccg
     5701 aggtgctcgc ggcgcgcgcg gtggtggccg acacggtggc ctggctggcc gcgcaccccg
     5761 ccgacaacga cgggtggcgg gaggccgaat ggcatgcctg ggcggtggat cgggccgcgg
     5821 agatccggac cttgcctaca ctgggacagg ccgggggaca cctgcgggac cggaccatgg
     5881 ccgaggcgtt gcggcggatc ctggccgaac ccggcgcgcg ggcgatggtg tgggcgcaca
     5941 acggacatct ggccgccgcc acccgctcca gcaaggaggc cgcgctcggc gccgaactgc
     6001 gggactggct cggcgacggc tactacgcgc tcgcgctggt gaccaaccag ggcgggttcc
     6061 aggcaatgaa actgggcacc agcgagctgg ctgagttcga gctggacccg gccgagtccg
     6121 gcaccctgga atggcagctc gcccaggccg ggggtgatca cctcctggac ctgcgggccg
     6181 cgggcgcgga tccggtgctg cgcgcgtggc tggacggcaa acagcggatg cgcgcctacg
     6241 gctcggtgat cgggttctgg cccgcgctga agaaggagac cgtgtccgtg cggctgggcg
     6301 cggagttcga cggcatcgcc tacctggacc gcaccacccg cgcccggccg cgcaccgacg
     6361 ccgccgaccg gaaatcgggt gcggacagcc gacgcggtgg tgtctgatcc ggtgatggcg
     6421 atcgtgatgg gcacaccgga cgtcgacggg ctgagcgcgg ccgtgcacgc gctgcaggac
     6481 tggcagtacg acggcgcgcc catgcaactg cacccgggcg atgtgggctg gtactggcgg
     6541 ctcggcgccg aggccaccgc cgcggcggtc cgcacctggc gccgggccgg acgactgctc
     6601 gccgtcggac tcctcgatgg cccggacctg ttgcggctga ccatcgaacc cgcggcgcga
     6661 caggacgagg agctggcccg gcaactggtc gccgacctga ccgacccagc ccgcggcgtg
     6721 ctgcccgcgg gcgcggtctg cctcgaagcg ccaaccgccc cactggtcaa ggacctgctc
     6781 gccgccgatg gctggcgcgc cgacgagccg tggacgccgc tgcgccgcga cctcaccgag
     6841 ccggtgccgg atccgggcgt gcggatcgag gtgatcggac cggagcgggc gcacgtgcag
     6901 gccgccgtgc tccggtccgc cttcggcacc tcgaagttca ccgacgaacg ctggcacgcg
     6961 atggccgccg gcctgcccta cgccgacgcc cggtgcctgg tcgcccacga cgagcagggc
     7021 aacgcggtgg cggcggtgac cgtgtggtca gccggtccgg gcaagccggg ggtgctggag
     7081 ccgatggggg tgcaccggga ccaccgcggt cacggccacg gcaccgcgat cagcctcgcc
     7141 gcggcggccg cgctccggga actgggttcc agcagcgcgc tcgtgtgcac cccgaccacc
     7201 aacgccggcg cggtcgccac ctatcggtca gcgggctttc agccgctgcc cgagcgcctg
     7261 gaccaacgtc gggacgcctg aagttccgcc tccgccgtcg agttggccca agtggtacgc
     7321 ccacttgggc caactcgacg tacgacttgg gccaactcga cgtccagaac ggccaacacg
     7381 ccgtacgaga acggccaaca cggggtgggt gggttagccg gcgcgttggg ttaggccggg
     7441 ggagcggtgg aattcggctt cgagggtggg gtcttccagt tcggcgaggg tgcgggcgta
     7501 ctccttgatc aggtcgtgga gtaggtagcg gccgggggcg gactcggtga gcaaatggtt
     7561 gtcgtacagg cgttccaggc cgtgccgggt ttccgccgcg gtcagtccgg ccaggaccga
     7621 ggtggtcggc aggtccacct cgacgccagc ggacaggccc aggcagcgga acagccgccg
     7681 tccttcggcg ggcaggccgc ggtaggagcg gtcgaacgcg gcggtgagcg tgacgttttc
     7741 cgcgtgcagc tcgctgagcc gggttcgcgc cgaggacagc agatcggcca ggtagcggtc
     7801 ggtccagcgc gggtggtggc gcacccgccc ggccagcagg gtgatcgcca gtggcagccc
     7861 gccgcacagt gacaccagct gccgggtcgc ggccggatcg gccggttgct cgcgcggacc
     7921 cgtcaggtgc tggaacagcc gggcggcctg ttccagcggc agcgggttca gctccagcga
     7981 ccgcaccccc tccagcgcgc tcagccgccg cctgctggtg atcagcaccc ggcagcggcc
     8041 aggacccggc aacagcggcc ggacctgctc atgcccggcc gcgtcatcca gcaccagcag
     8101 cattcgcttg tcccgcaagg actcccgcca cagcgcggcc cgcccgtgct cggtgtccgg
     8161 catcgccgcg gcgggcaacc cggccgcgtc cagcaggccg cccagcgcgg cgtgcgcgga
     8221 caacggttcc tgaccggcgg cgaaggcgtt gagccgcagg aagatcgtgc cgtccgggta
     8281 gtcgggggcg agcagccggg cggcgcgtac ggccagggtg gtcttgccga tcccgggcat
     8341 tccgtccagc acgtggattt ccgccgcggc cgcggacccg gtcagtcgcc gcagttcggc
     8401 gtcccggccg gtgaaggaga gcggatcggc gggcagctgt tccaccgcca ccgccggggt
     8461 gatcaccacc ggtgggcagg cccggcgcgg cggcgcggac agttccggat cccgggtcag
     8521 gatgcgctgg tgcaggccgc gcaacgcggg gccggggtcg atgccgagct ggtcggccag
     8581 tgcggtgcgg gcctcctgga acacccccag ggcctcggcc tgcctgcccg agcggtacag
     8641 cgcgagcatc agcaactccc gcaaccgttc ccgcagcggg ttgcgggtca ccagcgcggt
     8701 cagctcggcc accaccgagc ggtgttcacc acggtccagc gacagcgccg cggacagttc
     8761 ctgggccagc agacgggact cccgtaatcg cagccgatgc gcgtgcaggt aggggctgtc
     8821 caatccgctg aacggctcac cgcgccagcg gcccagcgcc gaactgaccg actcggtggc
     8881 cgcggccagc cgcccggccc gctgatgctc ctgggcggca tccagttcct gctcgaagac
     8941 cagcgcgtcc agctgatcgg gcgcaccgcg caacagataa cccgcgtcgg tgcgcagcac
     9001 caccgaatcc cggtcgtgcg tggcgccggc cggccgcagc gcgcggcgca accggctgat
     9061 gttggtctgc accgtgttgc gcgcgccctg cggcggcgag tccgcccaca ccgcctccac
     9121 caatgcctcc accggcaccg gctggttcat ccgggtgagc agaaccgcga gaaccgcctg
     9181 ttgccgggac cagcccagct cgatgtccac cggaccgcgg cgcgcggcca gcgcgccgag
     9241 tacctcgcag tacagcctgt tgtcgcgttc gggcacgtca aacccccaat tagcacagga
     9301 ggaggacacc atagcgcgct gctactgggg aaggcactac tcacagtaag acgtggtcat
     9361 cgggtcaccg caatcctgtg acagcgctgt gtacgcggcc gcacctaggg tccgaagtga
     9421 gcgcgagaca ttcgcgccgg aatgtcatcc ggtcgactga ccggagaact gatggaaagg
     9481 tgaagtgtcc catggatgcc tttgatctgg atgccagggt cagcactccg gccgcggcca
     9541 atggccaggc ccagccgctg tcgattacca gtgtgatcac ccgactggcc tgcacccgga
     9601 ccccgctctg ctcgaggttc acctgccagt gcacccaggg cgcctgcacc gccggttgcc
     9661 ccaagcgcta aaaaagcgca gctcaacggg ctgaaggcgg gtgctgccgg gtgtcgacga
     9721 cccggcagca cccgccgctc aacctaccgc atcctgcccg tgcgccgggc ggttggaaag
     9781 ccgacgaaca ggggttgtca tgcgcgcaga atcggagcga ggttccgctc ccaaccgggt
     9841 attggtggcc gatgaatccg tcgccgcctg gcatggagtt gttccgggcg cgcttgccgc
     9901 caaagcccgg gaagtcgcct gcgaggtcgc gcggagaacg gcggattccg ccaccgtcat
     9961 cgatcatgta atgcgattca ccgagcagac gaagcatccg atggaatggt acttccccag
    10021 cttcgggtat ggccacgccg gaatcgcatt actccatgtg cacgcttcgg cggccgcccc
    10081 caatgcggta gagagcgcgc gttcgctcag cgccggtttt gccttcatcc gggaggcggt
    10141 ggccggcacc caggcccagc cgctgctcgc gccgggggtg ttctccggca ccggtggcct
    10201 cgcgctgtgc gtggcgggct gcgccgaggc cgagccccgg ttcgcgccga gtctgggcag
    10261 gctgcacgac cagttcgccg cccagatcgc cgatctggac ctgccgatgg ttgagcgcgc
    10321 ggtcagcgac tccgactacg acatgatcag cggcgcggcc ggcacgctgg cctacctgtg
    10381 ctcgatcgcc gaaccggacc aggccctgca ccccgccgcg gacaagctcc tggactacct
    10441 gatctggctc agcgccccgc cccgcgacct caccctgacc cggcgctggc tgatcgcccc
    10501 cgaactgtgc gcgccgctgg gccgcgatcc acgcgagttc cccggcggct acctcaacct
    10561 cggcatggcg cacggcatcc ccggcgcggt cgccgcgctg gccgtggcct ggcagcgcgg
    10621 actgcgcagg ccagggcagg aggaggccat ccggcggatg accgactggc tgctggcggt
    10681 gcgccgcgcc gatccgcacg gaccggtgtg ggccaccgag atcccggtgg ccgccaccgg
    10741 cgaggaggtc cgtccgaacc agccgcacga ccagatcgcc tggtgctacg gcaccgccgg
    10801 tgtggccgtg tccctgctcg cggtggccga cgcgctgggc gatgaccagc tgcgcaccgc
    10861 cgcgatcgag gcgttcgagg gcgtgctgcg gcgcagcgtg gccgaacccg tgctctcgcc
    10921 gaccttctgc cacggcgtgg ccggattgct ggcgatctgc ctcgaattcg ccaccgcggg
    10981 cagcgacttg gcccgcgagc acacgccgcg gctgctgacc gaactgctcg gacacgccga
    11041 tccggccaac cccctggtgt tccgggatga ggaggagccg ggcgtgttcg tggacagccc
    11101 cgcgctgctc accgggtcga ccggggtggc gctgaccctg ctcgccgcgg tcagcccagt
    11161 ccggccgtcc tggctgaccg ccttcctggt gcggtgacca tggccgggcc acgctacgaa
    11221 cccgccgact tcttcctgct gcgcgccccc gcgctgcccg ccggggtcta ccaggacctg
    11281 ctcgccacca ccaccgacaa cccggaccag gcacgcgccg aggtaaggca acggttgtat
    11341 gctttggccg ctcagcccgc ggtgcgccgc gcgctgaccg tggccagcgg cgacctggtg
    11401 gacgcgctgg accgggcgga aagctcggcc accacggaca aacgcacccg gcggctgcac
    11461 tcccggctgc tgcgctacct gatccggatg accacccggc ccaccccctt cggtgcgttt
    11521 tctggcgtgg ccgtcggcga gttcggcccg gagaccactg cctgcctggg cgaatcagcg
    11581 ttgcgggaca accggatccg cgccgacatg gcctggctgc tcaccctgat caaacagctg
    11641 gagtccgatg agcagctgcg cccgcatctg cgggtggtgc tcaactccag cgtgcaccgc
    11701 agcggcgacc gcctcgtgct gccctacgcc gatatctacg gccacaatga caatcgcgcg
    11761 gtccgggtgc gggccaccac cgcggcgctg gcggtgacca ggctggccgc caccccgatc
    11821 ccactggccc agctgctcgc cggactggcc gaggagttcc ccggcgtcga cccggccaga
    11881 gtgagcgggc tggtcgagga actgcgcacg ctcaacttcc tcaccagcga cctgcgcccg
    11941 ccgctgaccg tggcccagcc cgaagcccag ctggccaagc aactcgccgg gatcgaggcc
    12001 gcgggcgaga tcgccgagtc cctgcgcgag gtgatcaacc tcgcccaccg cgccgccacc
    12061 gagcccgagc cggccgcact cgccgagctg accgccgccc agcgtgccct gactcccgag
    12121 cacaccggcc cgacctacca gctcgacgcc accctggacc tgccgcgcac ccggctctcc
    12181 ggcgcggtcg gcgaggcggt ggccgaggcg gtggactgcc tgatgcgcct gtccgccgcg
    12241 ctgccagggc acaaccatca tctggcccag taccgggacg ccttcaccga acggtacggg
    12301 ctgctcgccc tggtgccggt gctggaactg ctcagccccg aacacggcct ggacgcgccg
    12361 cccacctaca ccgagccgcc gcgcggctat ccgttgccgc acaacgtcca agaaccctgg
    12421 cagcaggact tcgaccgggt gctcaccgag ttcgccgtgc aggcctggtg cgcgggcgag
    12481 cacgagatcg agctgaccga cgagtggctg caccgcttcg ccccactgga ggacgccccg
    12541 ccgctcgcgc tgtacccggc cctggacgtc ttcgcgcaga tctctaccga ccggtcggta
    12601 gacagcggtg cgtggcgggc ggtgctgcgg caggagggcc tggccttcgg cggccggacc
    12661 tccgggcggt tcttcgacct gctcggcgag gacgcggtgg accggctgcg cggctacgcc
    12721 cggcgcgagg aggagctgag ccccgaggtc gtctacgccg aactgtgcta cctgcccaac
    12781 catggccgcg cggccaacgt ggcgctgcgc ccgttgctgc gcgggtacga ggtgccggtg
    12841 aacaccacgc cctcggtgcc gccggaccgg gtgatcgacc tggccgacct atgcgtcggc
    12901 gcgaacgagg accggttttt cctgtggtcc aagcggttgg gcaagcaggt ggtggtctcg
    12961 cagaaccaca tgctcagccc gcacgtggcg cccaacgtgg ccaggttcgt gctggaggtc
    13021 tccaacgacg gctacgccat gccctgcgga ttccgctggg gcccactgga aaccatgccg
    13081 ttcctgccca gggtcacccg cggcaaggtc gtgctgcgcc ccgcccagtg gaccctgaac
    13141 gccttgccgg gcaaggactt ccccgccgag gtgcgggcct ggcgggaccg ctggaaggtg
    13201 ccgcggcacg tgtacctggt ggaggcggac aaccggctgc tgctcgacct ggagcacccg
    13261 atgtgcctgg acgagctggc caccgaatgc aaccgcggcc cggaaccggt gaccctgcac
    13321 gaaatgctgc ccgccttcga ccagcagtgg ctgcgcgatg ccgacggcgc ggcctacctg
    13381 gaggagatcg tcgtcccgtt gatcgcgaag aacagcgcgg acaccgcgcg cagcgaggtc
    13441 accctcaccg caccgaccgg caacgcaccc gagatcatcc ggcagcacct gcccggcgga
    13501 cagtggacct tcctcaagct gtacgcgggc atcacccagc aggacgaggt catcgccacc
    13561 cggctgcgcg aactggtcgc gatgctgcgc gaacaggggc tcatcgaccg ctggttctac
    13621 atccgctaca tggacccgcg tccgcacctg cgcctgcgct tccgcgcggc cgatctcgaa
    13681 gtggcgccgc aacttctctg gtacctgacc atctggagtg gacagctggc cgaggagggc
    13741 ctggccttcg acaccgccat cgcgggctac accccggaga tcgaacgcta cggcggcccg
    13801 cccgtcttcg acaccgtgga gccgctcttc gccgccaaca gcgaggtcac cgccgagctg
    13861 gtcgcgttgc tgcacaacga caaggacggc atccggccgg agttcgccgc catcgccgcg
    13921 gtggacaccc tgtaccggca atggggtctg accccgcgcg aacgcatgga gttgctgccc
    13981 ggcagcggcg gcgcggacgc cgaggccgcg cgcaccgagt tccagcagca gcgggcctac
    14041 ctcaccgaac tgctcgtgcc ctgggactac cggccgcacg aactgggccg cgaccaccat
    14101 cggctgatca gcgaaatcct ggccccgcaa caggaatcgg tcgaagccgc cgcgcacgcg
    14161 gtgcgggtgg ccgcggccga gggcgtgctg tggggcgccg agtccagcgt gctgggcagc
    14221 ctggcgcaca tgcagatcaa ccggctgctg ccgatcgacc tgcgccggga atcgcacctc
    14281 tacgccgtgt ggcggcacac tttgcgcgcc atcggcggcc gacccgcacc ggaggcacgg
    14341 gcatgaccac caagaaccac tggctgcgga tcgccaagat gctgtgggac ctcagtccct
    14401 tgcgggtgct ggcgctgatc ctggtcaccg tcgcggtgtc ggtggtgccc gcggtgcagc
    14461 tgcaactcac cgccagcgcg gtgcagaccg tggccgacgc gatcaccgcc ggcggcgtgg
    14521 gcgagcacgg ctcggcggtg ctcgcggtgg gcctgctgat cctggccgtg tccgtaatgg
    14581 cgcacctgct cggggtgtgg cacggctatc tggactcggt gctgcggctg cacctgtcca
    14641 ccgcggtggg cgaggaggtg atgcgcaagg gcacccggat ggacctgcag gactacgaga
    14701 gcgccgactc ctacgacaag ttgcagcggg ccttccagga gagcagcgga tcgcgcatcc
    14761 accagctgtt caccgacacc ctcggcttcg cccgcgaact gatcaccatc ctgtccgtgt
    14821 ccgcggtgct gttctcctgg aacttctggg tcgcggtgct gatcctgctc tcgccgatcc
    14881 cgtccgccat cgcgcagatg tggtacggca agaagatgta cgagatcgag tacggccggg
    14941 ccgccgatcg ccgcaggctg ttctatctcc agtacctgac caccacggac cactcgttca
    15001 aggaggtccg gctcttccag ctcggcgacc atcttatcgg cgcctaccgg gaccaggtgc
    15061 gccgcttcct caaggtggac cgcgatctga cccgccgcca gtcggtctcg ctcggcgtgt
    15121 tcggtctgct cagcgtactg atctcggccg gtgcactggt gttcgcgatg ctgtccacaa
    15181 tggagactgg tcggctcggc gagctggccg ggtacctgca agccatcggg atcgtgcagg
    15241 catccgggca cagcctgctg gtgggtgtgg ccaacctgtt cgagaacaag ctgttcgtga
    15301 gcaacctgtt cgagctgttc gacctgcccg aacggcagat ccgcggcggc aaccggaaat
    15361 tcccggcgaa actgcgtcag ggcatcgaat tccgggaggt cagcttcacc tacccgggca
    15421 ccgaggacca ggttctcgac cgggtcagct tcaccctgcc cgcagggaac tgcgtggccc
    15481 tggtcgggca gaacggcgcc ggcaagacca ccctggtcaa actgctcacc aggctctacg
    15541 aacccaccgg cggccagatc ctcctcgaag gcgtgccgat cgaggaatac gacctggagg
    15601 agctgcgccg caacctggga gtgatcttcc aggactacat caagtacgaa ctgccggtgc
    15661 gggacaacat cggcttcggc cagatcgaac accgcgccga caccgcccgg gtccgccgcg
    15721 ccgccgaggc cagtggcgcg gattccattg tggacactct gtcggacggc tacgacgcca
    15781 tgctgggccg ccacttcgag aacggcagcc agctctccgg cggccagtgg cagaaggtcg
    15841 ccctggctcg ggcgttcatg cgggccgcgc cgatcgtggt gctggacgag cccaccgcct
    15901 ccatcgacgc agaggccgaa accgagatct tccaacgctt ccgcagcatc gcggaccgct
    15961 ccaccagcct gctggtggca caccggttct ccaccgtccg gatcgccgac aagatcatcg
    16021 tcatcgaggg cggccgactg gtcgaacagg gcacgcacgc cgaactgatg cgcctcggcg
    16081 gccactacgc ctacctgttc aacctgcagg ccgccggata ccagccggag cacacgtgaa
    16141 aacctcgatc ttcgtcccgg tgatgcccgc cagcccggcc gacctcaccc cgtacgccga
    16201 gttggtccgc gacaccgccg cccaccgcct gtggcagggc cagtccctcg gcctggaaac
    16261 ccaccagggc ttcgcctacc tggccggcgc tggcctgacc gtgccggtgg gcaccagcgt
    16321 caccctgacc gcgctgcgcc acccctacga ggccgccctg cacgcccgct ccctggccgc
    16381 gctcaccggc cacagcccgg tgctgggcat cggcgcgggc gccccggaac tcgtggaatc
    16441 cttgcacggc aagccctatc ccagcccact caccgcgatc gccgactacc tcaccatcct
    16501 gcgcggcctg ctcgccggcg aggtcgtcaa ccaccagggc cgcgagtacc gcatgcacgg
    16561 cgccctgccc ccactcgacc acccaccggt cgaactcggc ctcggcgtcc tgcgccccgc
    16621 cgcggcccgc ctggccgggg aactcgccga cgccgcgatc acctggatga ccccgccgga
    16681 ctacctccgc accgtcctgc gcccggaact cgaagctggc gccgccaaag ccggccgccc
    16741 tgtgccccgg atcgtggcgg tggtgcacgt cgcgatccgc cgctacggcc gcgatccaca
    16801 cctggtggcc ctgaacgcgg cccgcgaaca cctgtccgcc ccgcactaca tcgacatgct
    16861 ccgccgcgcc ggcctgcgcg tgcaccccgc ccaacccggc ctcagcgccc gcgccctggt
    16921 cgacgcggac gtggtcctca ccggctcggc ccgggagatc gcgactgggc tgcaacgcta
    16981 tcgggaggcc ggggtcgacg agatcgtgct caacacagcg ggggtccgga tgaccgagga
    17041 ccgcgacgcc gccctgcgcg atctcaccga cctcctggcc caggtgatca cgccggaatc
    17101 tcgccagcca gcccccgtcg gacatcccta acctcggcgg catgagcgcc gagatcgtcc
    17161 gacaagcctg gcagaccttc agcacccgcg accgggaccg gatcgccgcc gtcttcaccc
    17221 ccgacgcgga atggcttgcc ccggcaggga atgccaccgc ccgcgccctg gacatcacca
    17281 accacatggt gggccgcgag cagatcgcgc acttcctggc cgtggacttc ccccgcctgt
    17341 tcaccagcga tatcggggtc accttccgcg gcttccacgc cgtgggtgac acggtgatcg
    17401 tcgaggagac catgaccgcc accctggccg acggcagcca ctacgccaac gactactgcc
    17461 tggtcttcga ggtccacaat ggactgatcc accgggtgcg cgagtacctg gacaccgccc
    17521 gcggcgcccg ccagctgcac gccgtggcgc cgttaccgaa gtgacggagc acaccgggcc
    17581 gtacacatca cctccacaac atccgcacaa ctcgaaaatc aggtgcctgg cctgcgctga
    17641 tcccggttag ggtgcgcagg tcaggggcgg tcggcgcgcg attgaccctg ggggagtagt
    17701 tccggcgcgc accgaagcag aaacagagtg aacatgatgt cttccacccg cctcgccctg
    17761 ctcgccctca ccctgggtgg cgcgttgctc gccgccggtt gcggtggcgg cgcacccgcg
    17821 gctccggcca actgcgatca gcagcagtcc gcggtcgccg ccgcggagaa ggccaacacc
    17881 gaagccgaca ccgcggccaa gaccgccgag ggcaagctcg ccgaggtcaa caagaccaag
    17941 gacacggcca acgccgaggc cgacaaggcc agcgagaagg ccaaggaact gcacgagaag
    18001 gccaagaagg gcggcgccgc gcaggccgcc gactccgcgg aggccgcggc caagtcggcc
    18061 gacctgatgg ccaaggccac cgggctgatc gtggaggcca tggaggcccg cgagaaggcg
    18121 gaggccggcc gcaccaaggc caacgagacc gccaaggcgc tcaccgaggc caagcagaag
    18181 ctgaccgact gccgtaagtg acccgcgcgc ccggtccgcc acccccgaac cgggtggcgg
    18241 cggaccgggc ggctagcgtg agtgcgtgac cctgtacgac atcccgctgc agaccctcac
    18301 cggcgaaccc accaccctgg gcgagctgag cggcaaggcc gtgctgatcg tcaacgtcgc
    18361 ctccaagtgc ggcctgacca atcagtacct cggcctggag gccatccacg agcgctacgc
    18421 cgaacgcggg ttcgccgtgg tcggcttccc gtgcaaccag ttcggcggcc aggagccggg
    18481 cagcgcggcg gagatccaga ccttctgctc gaccagttac ggcgtcacct tcccgatgat
    18541 ggccaagatc gacgtcaacg ggccggaccg gcacccgctc tacgccgagc tggtcaccac
    18601 cgccgacgcc gcgggcgagg ccggcgacat ccagtggaac ttcgagaagt tcctgctcga
    18661 cccggcaggc aaggtagtgg cccgcttccg cccaaccacc acccccgagg acaacacggt
    18721 gatcaccgcc atcgaagccg ccctccccgc ctaacccacc ccgccccgtg ttggccgttc
    18781 tggacgccga gttggcccaa ctggtacgcc gagttggcca aagtgggcgt accagttggc
    18841 ccaagtcgta ccagttcggc caagactggg tacgacaacg gccaacacgg cggggggtta
    18901 ggggtattcg gtgaggtagc ggacctgggt ggtggtgttg gcggggccgc cgacgccgtt
    18961 gatgatgttg ctgattgtgc ctactccgcc cagggagacc gcggccaggt tgtgcatgcg
    19021 cacgcctggt tttcggggta cctcgaagga gttcgcggtg accacgctcg ggttgacgtt
    19081 gttgtagcag tagctgccca ggccccagcc ctcgtgccgg ttcaccgaat cggccacctt
    19141 gtacgccgcc cagccctggg tgccgccgtt catccaggac gcctggtccg gcgggtcgta
    19201 gggcagttcg ttctggaaca tgtaggtgcg gccgttctcg ccgttccaca gcacgttgtg
    19261 ctgctggtag tgctcggcga agaggccata ggcggtgacg tcggcgccgt tgaccaccac
    19321 gccgttcgcg ccggtgttca ccgtccagcc cacgccgtcg ccgtggtcgc cgcgccaggc
    19381 ccagacgtga tcgatgatcg tgtcgtggct gttgacccgc aggctcaccg tcgccttccc
    19441 agggcccgcg ccgccgaccc gcaggaacag gtcgtgcacg gacaccggat tggccgcgtg
    19501 gtcccggctc gatccgggct caccgagttc gaccagcacc ggcgagttca ccgggcccgc
    19561 gtccaccagc agcccggcca gcttcacacc gtccacatcg gacaccgaga tggccgcctt
    19621 gccggtggtg ggaatgacgg tggccagccc caatccgagc accacggtgt ccgggcgggt
    19681 gacccggatg gtgtcgtcga tccggtgcac gccaggggtg aacagcaggt gcctgccctg
    19741 gttgagcgcg gcgttgatgg tggccgccgg ggtgcccggc ttgaccaggt agaactggct
    19801 caacgagatc gaggaccccg ccgtgctgcc actggcccag ctggtgccgg aagcgttgtg
    19861 ccgcaacgag ggcacgaaca cgccgtagtc acccgcggcg ttcacgtgca ggaacggctt
    19921 ctcccggatc accggggtgg tgggcagcac ggtgtgcgag gggttgggga agttcggcgg
    19981 tggagtgccg gtggaaccga cgaagaccat gttccacacc gacccggccc agccgtccac
    20041 gagttgggtg ttgcgggtca tgaactgttg ctgcgaaccg gaaaccacca cgccgtcgat
    20101 cttgctgtcc gagatccagc cgccgctggc ccagccgtcg tgcccgttcc acaggtgcag
    20161 ctgcccgcgc acgtgcatcc gccggtacgg cgcggcctgc gccaccgccc agcgctcaat
    20221 ggtgttgggc ggcaaggtca ccgacatgtt ctccgcggac cgccagaagt tctgggtggc
    20281 gttgcccagg ttgttcgggt cctcgccctg ctgcaaccag tccgcctcca cccgcacgtg
    20341 cccgttgatg ttcacatcgt ccgggtgtag gccgagtccg gcgacctggg tgtagaagcg
    20401 gagatccaca tcggcgttgt agttgcccgg cttgaacaac accgcgtgcc gctgtggccc
    20461 gaactggttg gtccgctgtt ccctggcgat ggcgttcaat cggttctggg tgtccacagt
    20521 ggacgaacgc gggtcgacca cgagcacgtt cgggccgaag tccgggttgc gcggatcggt
    20581 cggcggcagc accggatcac tgccgtcggt caccgcgtac gcgccgacct cccacagcga
    20641 atagccgtac ccggtggccc gctgggtgcc gtgcacccgc aggtatcgcc cggtcccggc
    20701 cacgtcgagc tgctgcaggc cgcccgcgct gtcggtggcg gtgtgcacgc tccgccaggt
    20761 ggccgcgtca tcggagacct ggacctggaa tgccttggcg tgcgcggttt cccagttcag
    20821 ggtgacccgg cagagctgct tcgggccgcc caggtcgagc tggagccact ggggatcgct
    20881 gaacgcgctg gaccagcggg tgccggcatc gccgtccacc gccgcggcgg gttgggtgcc
    20941 gccgttctcg gtggaggagc tggtcgccgg gcggtgcagc gcgaggttct cggtgccgca
    21001 ggcggccgcg ctggcagccg gagcggcgat cggactgagc aggggggcca ggccgagggc
    21061 cgcggcgagc acggcgattc ggcgcagccg gagagctgac gcagggctca tcgatccacc
    21121 tgaggtcggg ggacgcagac ggtgagagag cgctctcttc gagcgtaaag cgcaagtttc
    21181 cggcaagtca acgccagtgc cccggctgcc cgggagtgcg cgccggagct tgtgtctgta
    21241 cctactagta tgtatggtca gctcgtggac accagggaga agctcatcga gagcacgcgc
    21301 gaactgctgt gggagcgcgg gtacgtcggc accagcccca aggccatcca ggaacgttcc
    21361 ggcgcgggcc agggcagtat gtaccaccac ttctccggca aacccgagct ggcgctggcc
    21421 gcgatcaccc gcagcgccga ggagatgcgc gagcgcgccg acgccgagtt caccgcgcgc
    21481 ggcaccgtgc tcgcccgcat caccgcctac ctgcgccgcg aacgcgaggt gctcaagggc
    21541 tgcccggtcg gccgcctcac ccaggacccg gaggtgatgg ccgacccgga cctgcgccgc
    21601 ccggtggagg agaccttcgc ctgggtcacc acccgcctga ccacgctgct cgccgagggc
    21661 gtgcagagcg gcgaactcag catcccggac ccggccgcca ccgccaccgc gctggtcgcc
    21721 gtggtgcagg gcggctacgt gctggcccgc gccgagggtt cggccgaggt ccacgcccgc
    21781 gccatggacg gcatcctcgc cctgctcgcc gccgccaaga acccggaagg aaagtcctga
    21841 caatgccctt cgttcgcatc gacgccctgc acgccgacca gtcccgcctg gaagccctcg
    21901 gcaacgccgt gcaggacgcc ctggtcgaga ccatcggtgt cccaccggat gaccggttcc
    21961 aggtgctggt gagccacgac ggggtcagca gcacgctgcg gtacgacaat ttccttggta
    22021 tacacaagga tgacgggatc gtgttcatcg cgatcacgtt gcgggccggg cggtcggcgg
    22081 agttgaaaca ggcgctgtac cggcggatcg ccgagctggc ccaggagtac gcgggcaccg
    22141 aaccgcgcaa cgtgctggtg aacctggtcg agaacgagct gctggactgg tccttcggca
    22201 acggggtggc gcagtacgcc gccggcatcg acaggtagcc cggcggctcc cggatgctgg
    22261 gagcccttgc ccaatccgtg gccaggccgg atcatcaggg catggcaatc gagcggaacg
    22321 tgggcgcgcc ctgcgcgtgg tcccgctggt gtggcgtccg gaccgccgcg ctgctggttc
    22381 gccatggccg gctgggatcg ccgcccgcgt agcgcgtcac ctcgcgtccg cagccgctcg
    22441 atcccaagga ctcctgtcat gaccacacat gtgccgatcc tgcgcgccgc cagcaccccc
    22501 gatgacggca ttctcgaagg ctcccggcaa ctccgccgcc tgcccgaggg cattgcggag
    22561 cgaccctacg aactgttcac cctgcgcccg ctgggccggg tgatcggcgc ccagatccac
    22621 ggcgtcgacc tggccgaacc actgactccg ttgctgcgtg acgaggtgaa ccgggcgttg
    22681 ctggagtgga aggtgctgtt cttccgggag cagcggatca cgccggggca gcagcgggcc
    22741 tttgccgcgc actgggggga gctggagacc aatccgttca tcccgcaggg cgataccgcg
    22801 gaggtgaccc ggttcgagcg cagcgcggcg atgccggggc tggagaacat ctggcacacc
    22861 gacgtcacct tccggcccaa tccggcgctg ggttcggtgt tgcggctgct cactgtgccg
    22921 ccgatcggcg gggacacgct gtgggcggac atggccgccg cctacgacaa cctgcccgag
    22981 tcggtccggg aacggatcga gggactgcgg gccgtgcacg actacctgcc cgggttcgac
    23041 cgcttcaccg acccggaact ccttgcccgc caccaggaac agttcccgcc ggtgacgcac
    23101 cccgtggtcc gccgtcaccc ggaaaccggc cgccgcactc tgttcgtcaa ccaggccttc
    23161 accacccaca tcgttggcct gccccgcgcg gagagcgacc gcctgctgca ctacctgttc
    23221 acccaggcgc acgtccccga gtaccaggtc cgcttccgct ggcagccgga ttcggtggcg
    23281 ttctgggaca accgggcgac ccagcactac gcggtcaacg actaccaccc gcatgccagg
    23341 gtggccgagc gggtggcgat cgcgggggac cggccgtact gaccaccgcg gcttgaccct
    23401 gccccaggga ccgggttcga gcatggcggc atgagcggga actggtcgac ggggtggcga
    23461 cggctgttgg tgatcatccc ggcggtggtg ctcggcgggg aggccgtggc actgctgacc
    23521 gggctggtca gttggcggga cgcactgcta ctgctggtag tgctggagat tccgcacatc
    23581 gcgctggtgc tcgggtcgat gggctacgcc acggtgctcg cgatccggcg caggcgggcg
    23641 ggggagccgc gatggaccgc gttccggcgg tcctactacc aggtgctgcc cacgccactg
    23701 gcctgggcgg tcaccaggga gctggccagt ctggtcgcgg tcggcacgct cctgcggcgg
    23761 ccgcggccgg ggatcggcgg gtacagcgcg gggcggggcc gggtgttcgc ggtgctgctg
    23821 gtggtcatcg tggtcgagct ggtggtgctg caccagctga tcccgtggcc gggggtgcgg
    23881 ctggcgcatg acctggtcgg gctgtactcg ctggtcatcg tggtgggtta ctgggcggtg
    23941 ccgcgcaccc acccgcaccg gctgctgccc gaccggctgg agttgcgcgc cggacatgat
    24001 gtggtggtga cggtgccctg gccgggaacc gtggtggccg aacgggaaac gcggccgggg
    24061 cgggcggcga tcaccgacga cgtgctggtg ctgccgaacg ggcgtggcct caccaacctg
    24121 accctgcacc tgccggagcc ggcgaccgca cggctgggcc ggagcggcgg gctggtgcgg
    24181 gtgattgaac tgggtgtgga ggatccggcc gggttccggg cggcggtgcg ggtgtagcgt
    24241 ccccggcatg ggggatgagc tgtggcggcc ggggcagatt gtccttgact tgtatgaggt
    24301 tctggcggtg atccgcaccg gcggcatggg cctggtccac cgggtg
//
