LOCUS       NZ_JALMDK010000005     10816 bp    DNA     linear   CON 13-SEP-2024
DEFINITION  Crossiella sp. S99.2 NODE_5_length_810412_cov_140.901150, whole
            genome shotgun sequence.
ACCESSION   NZ_JALMDK010000005
VERSION     NZ_JALMDK010000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Crossiella sp. S99.2
  ORGANISM  Crossiella sp. S99.2
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Crossiella.
REFERENCE   1  (bases 1 to 810412)
  AUTHORS   Gonzalez-Pimentel,J.L.
  TITLE     From North to South: A Spanish map of bacteria producing bioactive
            compounds in show caves
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 810412)
  AUTHORS   Gonzalez-Pimentel,J.L.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-APR-2022) Agroquimica, Microbiologia Ambiental y
            Conservacion de Suelos, Instituto de Recursos Naturales y
            Agrobiologia, Av. Reina Mercedes 10, Sevilla 41012, Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2021
            Assembly Method                   :: SPAdes v. 3.14.1
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 200x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023094165.1-RS_2024_09_13
            Annotation Date                   :: 09/13/2024 06:26:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,481
            CDSs (total)                      :: 9,422
            Genes (coding)                    :: 9,365
            CDSs (with protein)               :: 9,365
            Genes (RNA)                       :: 59
            rRNAs                             :: 2, 1 (5S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 1 (5S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 8 of 57
            Pseudo Genes (incomplete)         :: 50 of 57
            Pseudo Genes (internal stop)      :: 4 of 57
            Pseudo Genes (multiple problems)  :: 4 of 57
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:32:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 396489
            Orig. end                         :: 407305
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JALMDK010000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10816
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10816
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10816
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5816](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5816)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(366..377)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     misc_feature    complement(673..688)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.22"
                     /tool="antismash"
     gene            917..2380
                     /gene="hemG"
                     /locus_tag="MZC64_RS21555"
                     /old_locus_tag="MZC64_21570"
     CDS             917..2380
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099296.1"
                     /locus_tag="MZC64_RS21555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_21570"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_247758572.1"
                     /transl_table=11
                     /translation="MTSAAQRVAVIGGGIAGLTVAHRLRGLLGEQVRVTVLEQTDRLGG
                     KLRTEELAGGPVDVGAEAFVTRRTEGLELVTELGLTAGLRHPLRAAPTIRAGGATRPLP
                     ARTFLGVPAEPALLREVLSADGFARAMAEPELPPLRPDGPGWDATVADLLGTRFGPEVV
                     DRLAEPLLGGVYAGRAEGLGVRATMAPLVDALERGAGSLTAAAAQTLGPGPKPGETRPP
                     VFGTLTGGLGDLVARLAETSGAELRLGVTVRGLRRTAEGWRLELGSAASPEFLDADAVV
                     LAVPAPAARKLLAEDVPAAAAAYGRIEVSSMAVLALALPPDTELPAASGVLLAVGEKHT
                     DGTPFTAKAFTFSSRKWGHFAERGTLLRASVGRFGETATLQRDDAELIAAVRADLAELT
                     GVRAEPVDSVVRRWGGGLPQYALGHTATVAAIEAAVAEVPGLAVAGASLHGVGIPACIA
                     TGQAAATRVATHLAVARRPTGASMGTWPA"
     gene            2368..3063
                     /gene="hemQ"
                     /locus_tag="MZC64_RS21560"
                     /old_locus_tag="MZC64_21575"
     CDS             2368..3063
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983668.1"
                     /locus_tag="MZC64_RS21560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_21575"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_247758571.1"
                     /transl_table=11
                     /translation="MARLNYNELNDTIRYTMWSVFRIQQGALPEDRAQAGAATAEYLES
                     LEGKGVVVRGVYDVAGLRADADFMIWWHAEEIEQVQEAYNGFRRTTPLGRASTPVWSNV
                     ALHRPAEFNRSHIPAFLAGEEPRKYICVYPFVRSYEWYLLPEEERRKMLADHGKEARDY
                     PDVRANTVASFALGDYEWMLAFEADELHRIVDLMRHLRGTEARLHVREEIPFYTGTRLP
                     VADLITNLP"
     gene            3080..3712
                     /locus_tag="MZC64_RS21565"
                     /old_locus_tag="MZC64_21580"
     CDS             3080..3712
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019846.5"
                     /locus_tag="MZC64_RS21565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_21580"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_247758570.1"
                     /transl_table=11
                     /translation="MRKAVRVAVAAGAWTALAGATWFALARLATAVSLRRGAELQRWRW
                     LHELLPLHLRRFLLVTAGVDESVPALRSVLAPARGLVVDVIAHRRAVVSLLRPETVRVV
                     PARPESLPGRPGSVDVVLAVFAAHELREPAEREALFAEARRLLSADGRMVLIEQHRTVR
                     TLAAFGPGAWQFYPSEEWRRAAALAGLKVVATRQVSPFVTGWALAAG"
     gene            complement(3725..4288)
                     /locus_tag="MZC64_RS21570"
                     /old_locus_tag="MZC64_21585"
     CDS             complement(3725..4288)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018681026.1"
                     /locus_tag="MZC64_RS21570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_21585"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_247758569.1"
                     /transl_table=11
                     /translation="MSPTGRVLSTADERRETVLRTAVGAFAAKGYYGTTTTEVAKLAGI
                     SQAYIYRLFPNKEALFVAVVQRCFDQIQEALTGGAAAVEASAPEVVLSAMGEAYARLVA
                     DRDLLLLQLHAQAAAASDELVRAAVQRGYARLVEYVRDASGGTDYQVQEFFSRGALCHL
                     VVAMGAEQVDAPWAETLSAGIRHY"
     gene            complement(4615..5004)
                     /locus_tag="MZC64_RS21575"
                     /old_locus_tag="MZC64_21590"
     CDS             complement(4615..5004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099301.1"
                     /locus_tag="MZC64_RS21575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_21590"
                     /product="hypothetical protein"
                     /protein_id="WP_247758568.1"
                     /transl_table=11
                     /translation="MTTPDRTRLAKAQAELLQALLANGPAPAGFDPARLHAQSLALRAK
                     RRRVTAALRPDLPERLGPRFRPLFDEYATTHPRHEGTGARTDANTFATWLTQSGHLPKP
                     RRRWWPRRATTANTPYKNGQHADKA"
     gene            complement(5001..5816)
                     /locus_tag="MZC64_RS21580"
                     /old_locus_tag="MZC64_21595"
     CDS             complement(5001..5816)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005450247.1"
                     /locus_tag="MZC64_RS21580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_21595"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_247758567.1"
                     /sec_met_domain="DUF692 (E-value: 3.3e-87, bitscore: 287.4,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGIPRLGVGIGWRPEIDLTVERLPQVDFVEVVAENLSGPTLPES
                     LEILRARGIPVLPHAVTLSLGGADPVVPDRVRHLAEVAERLGAPLVSDHVAFVRAGGLE
                     AGHLMPVPRTRDALNVLCANVKAAQQDLPVPLALENVAALIEWPGNEFTEAQFLTELAD
                     RTGCHLLIDVANLHANNLNLGTNPEEFLSTLPLERLAYVHVAGGTTEHGLYHDTHAHAV
                     PQEVLDLLADLCARATPPGVLLERDDAYPPDAELAAELAAIRAVVEAPR"
     gene            complement(5813..6682)
                     /locus_tag="MZC64_RS21585"
                     /old_locus_tag="MZC64_21600"
     CDS             complement(5813..6682)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="MZC64_RS21585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_21600"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_247758566.1"
                     /transl_table=11
                     /translation="MHNTWGLTGPEFIGLYVLALIITVAVAIRRRLAARKLPPGHPTAP
                     ALTADEAAYLAGGTRRLVETALARLVAGDALRVSRGNPPAATGRPAESTMDARVLTAVR
                     DRKTRVGVEDATQQLDRSPELRELRQRLLWAHLLVSTERSRACRMAAAMVFLPIALIGA
                     LRLSDGASNGKPIAILIFLLAVTTVLALVITLVPGPRATTLGQRALNSARADAHRRRLA
                     GVTAGGFVAGDVVLLVALSGMSGHPDSAVASGLATDGGGGGGGGSGCSGGGGGCSGGGG
                     GGGGGCGG"
     misc_feature    complement(6666..6680)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 21.66"
                     /tool="antismash"
     gene            complement(6719..7624)
                     /locus_tag="MZC64_RS21590"
                     /old_locus_tag="MZC64_21605"
     CDS             complement(6719..7624)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="MZC64_RS21590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_21605"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_247758565.1"
                     /transl_table=11
                     /translation="MTETWGLTGPQFLLLYGMGLLVSIVVAVWARRSVRRAEAAPGAGR
                     LSADDVAYLAGGGDQVVFTAVARMLEAGSLRASRGSWLSVTGLAAQHPLDRVILAELNA
                     RTSPAATLGSLRAKYADHPLVGQVRNRLETLGLVVPRRRQALARLRGAAAFGLLLLIGV
                     ARVVDGVGNGRPIGYLAGLLGLTAPVALVLLITKMNRLTLAGEQTLNHFRTNVFRKPAA
                     DDHDQLALIGGAAMLVALGGLAAFPDETVSRVLALPSSGGGSSGGSSCSGSSSSSSSSS
                     SCSSSSGDSGGGGGGGGCGG"
     gene            complement(7668..8600)
                     /locus_tag="MZC64_RS21595"
                     /old_locus_tag="MZC64_21610"
     CDS             complement(7668..8600)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="MZC64_RS21595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_21610"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_247758564.1"
                     /transl_table=11
                     /translation="MDNPWGLTGPEFLQLYAVGLAVALVLAGWIRIAGRRPDAHATTQV
                     GEVTTVELAYLVGGSSRAVETVVAGLLEREALRAARGGYVSGTGPLLLKDPVARQVREY
                     TGDTGRGTLRLLVHRVADSQAVTDVGARLVDRGLLVPPDRLPGMGFRSALPLIALGALG
                     VVRAIDGASRDFPVGYLMLLLVLTGVLAAFAAWLPVAWRTQAGDAAVERALKSTSDSAA
                     EHVARDGIAAYPDASVRSALLGHSARQQVHGTRGGRRSRGLNDTGFLAGGYAGGFSAGG
                     GGGGDSGGGGGGGGGCGGGGGGCGGGGGS"
     gene            complement(8769..9194)
                     /gene="msrB"
                     /locus_tag="MZC64_RS21600"
                     /old_locus_tag="MZC64_21615"
     CDS             complement(8769..9194)
                     /EC_number="1.8.4.12"
                     /GO_function="GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005457581.1"
                     /locus_tag="MZC64_RS21600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_21615"
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="WP_247758563.1"
                     /transl_table=11
                     /translation="MDQGPKVVKTEQEWREQLTPEEYRVLRQAGTERAWTGEYTDTKTA
                     GVYECRACGAELFRSDTKFESHCGWPSFFTPLAGEAVVLREDRSMGAVRTEVLCGTCHS
                     HLGHVFEGEGFPTPTDQRYCINSVSLRLVAAPESEES"
     misc_feature    9238..9252
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.8"
                     /tool="antismash"
     gene            complement(9243..9551)
                     /locus_tag="MZC64_RS21605"
                     /old_locus_tag="MZC64_21620"
     CDS             complement(9243..9551)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099308.1"
                     /locus_tag="MZC64_RS21605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_21620"
                     /product="hypothetical protein"
                     /protein_id="WP_247758562.1"
                     /transl_table=11
                     /translation="MRAAAPDDEPQGPPGRFGEDLVGLDPHDPEARAFAQHLDRIEHAP
                     KPYTVEGYLAGVSEFADSANRVGGGRRLTAVVLAGLIVLGLILTFTGALNTILLFLF"
     gene            9577..10221
                     /locus_tag="MZC64_RS21610"
                     /old_locus_tag="MZC64_21625"
     CDS             9577..10221
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012514.5"
                     /locus_tag="MZC64_RS21610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_21625"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_247758561.1"
                     /transl_table=11
                     /translation="MNRADTDTTPHYDPALGLAGLPSAPRWESAGQRSLYRSDWVSLDL
                     IAVRPPTAPPYEHHVVRTADAVAVVLEHPERGVLMLHRHRFITETTGLELPAGGIDPGE
                     DPVAAAVRETAEETGWAAVRPRLFLTRCVSNGNSDQLFHFVHAEVGQWLGGPESPDEGP
                     AVWVRHEHLRDVLGRDLVSCAPSSLGLLHAMTFGLLRAGAGAGSVQAREQG"
ORIGIN
        1 cgatgttgcg ctcctgcttc atgccggagc tggtctgcga gatcaccatg cagccggtcc
       61 ggcggcacgg tgtggacgcg gccatcctgt tcagcgacat cgtggtgccg ctggccgccg
      121 ccggggtcga tctggacatc gtgcccggca ccggcccggt ggtcgcgaac ccggtccgct
      181 ccatccacga cgtggagaag ctgccggtgc tcgaccccga gcaggtcgcc ccggtcgccg
      241 aggcggtcgg gttgctgacc aaggagctgg gcgagacgcc gctgatcggc ttcgccggcg
      301 cgccgttcac gctggcctcc tatctgatcg agggcgggcc cagtcgcaac cacgagcgca
      361 ccaaggcgct catgtacagc gacccggccg cctggcacgc gctgctcggc cacctcgccg
      421 acatggcgct gaccttcctg tccgtgcagg tccaggccgg ggtggacgcg atccagctgt
      481 tcgactcctg ggcaggcgcg ctctccgaac gggactaccg cgagttcgtg ctgccgcatt
      541 cggcgaaggt cttcgccggg ctggccgagg cgggcgtgcc gcggatccac ttcggcgtgg
      601 gcaccggcga gctgctggtg gccatgcgcg aggcgggcaa cgacgtggtc ggcgtggact
      661 ggcgggtgcc gcttgaccag gcggtcgacc gcctgaccag cgcccggccg gacctgccca
      721 agccggtggt gcagggcaac ctggacccgg ccgtgctctt cagcggcgag gacgtgctcg
      781 cgcgcgagat caaccggatc ggcgccgaag gccgggccgc ggccgggcac atcttcaacc
      841 tgggccacgg cgtgctgccg gagaccgacc ccgggaagat cacccgcgcg gtcgagctgg
      901 tgcacggcct gcggccatga ccagcgctgc gcagcgggtc gcggtgatcg gcggcggcat
      961 cgccgggctc accgtggcgc accggctccg cggcctgctc ggcgagcagg tccgggtcac
     1021 cgtgctggag cagaccgacc ggctcggcgg caagctgcgc accgaggagc tggcgggcgg
     1081 accggtggac gtgggcgcgg aagccttcgt cacccgccgc accgagggcc tggagctggt
     1141 caccgaactc ggcctgaccg cgggcctgcg gcacccgctg cgggcggccc cgaccatccg
     1201 ggccggcggg gccacccggc cgctgccggc acgcaccttc ctgggcgtgc ccgccgagcc
     1261 tgccctgctg cgcgaggtgc tcagcgcgga cggcttcgcc agggcgatgg ccgaaccgga
     1321 gctgccgccg ctgcgcccgg acggccccgg gtgggatgcc acggtcgcgg acctgctcgg
     1381 cacccggttc gggccggagg tggtggaccg gctggccgaa ccactgctcg gcggggtcta
     1441 cgcgggccgc gccgagggcc tcggcgtgcg cgccacgatg gcgccgctgg tcgacgccct
     1501 ggaacgcggc gccggctcgc tgaccgccgc ggccgcccag acgctcggtc cgggccccaa
     1561 gccaggtgag acccggccgc cggtcttcgg caccctcacc ggcggcctgg gcgacctggt
     1621 ggcccggctg gccgagacct cgggcgcgga gctgcggctg ggcgtgaccg tgcgcggact
     1681 gcgccgcacc gccgagggct ggcgcctcga actgggttcg gcggccagtc cggaattcct
     1741 ggacgccgac gccgtggtgc tggccgtgcc cgccccggcc gcgcgcaaac tgctcgccga
     1801 ggacgtcccg gccgccgccg cggcctacgg gcggatcgag gtctcctcga tggcggtgct
     1861 cgccctcgca ctgccgccgg acacagaact gcctgccgcg tccggagttc tgctggccgt
     1921 cggcgagaaa cacacggacg gcacgccgtt caccgccaag gcgttcacct tctccagccg
     1981 caagtggggt cacttcgccg agcgcggcac gctgctgcgc gcctcggtcg gccgcttcgg
     2041 tgagaccgcc accctgcaac gcgacgacgc cgagctgatc gccgcggtgc gcgcggacct
     2101 ggccgaactg accggggtgc gggccgagcc ggtggactcg gtggtgcggc gctggggcgg
     2161 cggactgccg cagtacgcgc tcgggcacac cgcgaccgtg gccgcgatcg aggccgccgt
     2221 ggccgaggtg ccggggctgg ccgtggcggg cgcgagcctg cacggggtgg gcattccggc
     2281 ctgcatcgcg accgggcagg ccgcggcgac ccgtgtcgcc actcacctgg ccgtcgcccg
     2341 ccgcccgact ggtgcgagta tggggacatg gcccgcctga actacaacga actcaacgac
     2401 accatccggt acaccatgtg gtcggtcttc cggatccagc agggcgccct gcccgaggac
     2461 cgcgcgcagg ccggggcggc caccgcggag tacctggagt cgttggaggg caagggcgtt
     2521 gtcgtccgcg gcgtctacga cgtcgccggg ctgcgcgccg acgccgactt catgatctgg
     2581 tggcacgccg aggagatcga gcaggtgcag gaggcctaca acggcttccg ccgcaccacc
     2641 ccgctcggcc gcgccagcac cccggtgtgg agcaacgtgg cgctgcaccg gcccgcggag
     2701 ttcaaccgca gccacatccc ggcgttcctg gccggggagg agccgcgcaa gtacatctgc
     2761 gtgtacccgt tcgtccgctc ctacgagtgg tacctgctgc cggaggaaga gcgtcgcaag
     2821 atgctcgccg accacggcaa ggaagcccgc gactacccgg acgtgcgggc caacacggtg
     2881 gcctccttcg ccctcggcga ctacgagtgg atgctggcct tcgaggcgga cgagctgcac
     2941 cggatcgtcg acctcatgcg gcacctgcgc ggcaccgagg cgcggctgca cgtgcgcgag
     3001 gagattccgt tctacaccgg cacccggctc ccggtcgccg acctgatcac caacctgccc
     3061 tagcccctgg aaagtgctga tgcgcaaggc agttcgcgtc gccgtagccg cgggagcctg
     3121 gacggccctc gccggtgcca cctggttcgc gctggccaga ctggccaccg cggtgagcct
     3181 gcggcgcggc gccgaactgc agcgctggcg ctggctgcac gaactgctgc ccctgcacct
     3241 gcgccggttc ctgctggtca ccgcaggggt ggacgagtcg gtgcccgccc tgcgcagcgt
     3301 gctggccccc gcccgcggcc tggtcgtgga cgtgatcgcg caccggcggg ccgtggtcag
     3361 cctgctccgc ccggagacgg tgcgggtggt cccagcccgc ccggaatcgc tgcccggcag
     3421 gccgggttcg gtggacgtgg tgctggccgt gttcgccgcg cacgaactgc gcgaaccggc
     3481 cgagcgcgag gcgctgttcg ccgaggccag gaggctgctc agcgcggacg gccggatggt
     3541 gctgatcgaa cagcaccgga ccgtgcgcac cctggccgcg ttcgggcccg gggcgtggca
     3601 gttctacccg agcgaggagt ggcggcgggc ggcggcgctg gccgggctga aggtggtggc
     3661 cacgcggcag gtgagcccgt tcgtcaccgg ctgggccctc gcggccggct gagtcgcgcg
     3721 cgtctcagta gtgccggatg cccgcggaca gggtttccgc ccagggcgcg tccacctgct
     3781 cggcgcccat ggccaccacc aggtggcaga gcgctccgcg ggagaagaac tcctggacct
     3841 ggtagtcggt gccgccggag gcgtcgcgga cgtactcgac cagccgcgcg tagccccgct
     3901 gcaccgccgc ccgcacgagt tcgtcggagg cggccgcggc ctgggcgtgc agctggagca
     3961 gcagtagatc gcggtcggcg accaggcggg cgtaggcctc gcccatggcg ctgagcacga
     4021 cttcgggcgc actcgcctcg accgccgccg cgcccccggt gagggcttcc tggatctggt
     4081 cgaagcatcg ttggaccacg gccacgaaca gcgcttcctt gttggggaag aggcggtaga
     4141 tgtaggcctg ggagatcccg gcgagcttgg cgacctcggt ggtggtggtg ccgtagtagc
     4201 ccttggccgc gaacgcgccg accgcggtgc gcagcacggt ctcccgccgt tcgtcggccg
     4261 tggagaggac tcgtccggtg gggctcatgt gagtaataaa ccactcacac ttggcgtggt
     4321 caagtcgtgg cgtggttggc gagcaagatc aaagtcaagg gcgaaggtca agatcaaggg
     4381 cgttctcgcc ggacgggcag gaatcaaagg atggggaacc gctcggggag ggtttgaaaa
     4441 gccagcccgg ctgcctgttc gggcttcgcc cggtcgcggg ggcttggaac cgcctggctc
     4501 cgggcttcgc ccgcctgctc cccacggtcg ccgcctggcg cgcccacaac ggccaacccg
     4561 gcgtacgaca acggccaaca caccgtccac aacggccaac acgccggtgg ggtttcaggc
     4621 tttgtcggcg tgttggccgt tcttgtacgg ggtgttggcc gttgtggcgc ggcggggcca
     4681 ccagcggcgg cggggtttgg ggaggtggcc ggattgggtt agccaggtgg cgaaggtgtt
     4741 ggcgtctgtt cgggcgccgg tgccttcgtg gcgggggtgg gtggtggcgt actcgtcgaa
     4801 cagggggcgg aagcgggggc ccaggcgttc ggggaggtct gggcggaggg cggcggttac
     4861 ccggcggcgt tttgcgcgta gggcgaggga ttgggcatgc aggcgggctg ggtcgaagcc
     4921 cgcgggtgcc gggccgttgg ccaggagggc ttggaggagt tcggcctggg ccttggccag
     4981 gcgggtgcgg tcgggggtgg tcatctgggg gcctcgacca cggcgcggat ggctgccagt
     5041 tccgcggcca gttcggcgtc cggtgggtag gcgtcgtcgc gttcgagcag gacgccgggt
     5101 ggggttgccc gggcgcacag gtcggccagt aggtcgagga cttcctgggg gacggcgtgg
     5161 gcgtgggtgt cgtggtagag gccgtgttcg gtggtgccgc cggcgacgtg cacgtaggcc
     5221 aggcgttcca gcgggagggt gctgaggaat tcctcggggt tggtgcccag gttgaggttg
     5281 ttggcgtgca ggttggccac gtcgatgagg aggtggcagc cggttcggtc ggccagttcg
     5341 gtgaggaact gggcttcggt gaactcgttg ccgggccact cgatcagggc cgcgacgttc
     5401 tccagggcca gtgggaccgg gaggtcctgt tgggcggctt tgacgttggc acacaggacg
     5461 ttgagggcgt cccgggtgcg ggggacgggc atcaggtggc cggcttccag gccgcccgcg
     5521 cggacgaagg ccacatggtc gctgaccaac ggggcgccca ggcgttcggc tacctcggcc
     5581 aggtggcgga cccggtccgg cacaacggga tccgcgccgc ccagggacag cgtgaccgcg
     5641 tgcgggagga ccgggattcc cctggcgcgc aggatttcca gggactccgg gagggtgggg
     5701 ccggacaggt tctcggccac cacctccacg aagtccacct ggggcaggcg ttccacggtc
     5761 aggtcgatct ccgggcgcca gccgatgccg acgcccagcc gcgggattcc actcatccgc
     5821 cgcaacctcc gccgccgccc ccaccgccgc cactgcaacc gccgccgcca ccggagcagc
     5881 cgctgcctcc gccaccccca ccgccgccgt cggtggccag gcccgaggcc acggccgagt
     5941 ccgggtggcc gctcattccg ctcagtgcca ccaggagcac cacatcgcct gccacaaagc
     6001 caccggcggt gacgccggcc agcctgcgac ggtgggcgtc ggcgcgggcg ctgttcagcg
     6061 cgcgctggcc cagcgtggtc gccctcggtc ccggcacgag ggtgatgacc agggcgagca
     6121 cggtggtcac ggccagcagg aagatcagga tcgcgatcgg cttgccgttg ctggccccgt
     6181 cggagagtcg cagcgcgccg atcagcgcga tcggcaggaa caccatggcc gcggccatcc
     6241 ggcacgcgcg ggagcgttcc gtgctcacca gcaggtgcgc ccagagcaac cgctgccgca
     6301 actcgcgcag ctccggggac cggtcgagtt gctgggtggc gtcctcgacg ccgaccctgg
     6361 tcttgcggtc ccgcaccgcg gtcagcaccc gggcgtccat tgtggactcg gcgggcctgc
     6421 cggtggccgc gggcggattg ccgcggctga cccgcagcgc gtcgccggcg accagccggg
     6481 ccagcgccgt ctccaccagc ctgcgggtgc cgcctgcgag gtaggccgcc tcgtccgcgg
     6541 tcagcgctgg cgcggtcggg tgaccgggcg ggagcttgcg ggcggccagg cggcggcgga
     6601 tcgccaccgc gacggtgatg atcagcgcca gtacgtagag accgatgaac tccgggccgg
     6661 tgaggcccca ggtgttgtgc atgtcgccac ccccagggtg ccgtggtgag ttacgggatc
     6721 agcccccgca gccgcctccg ccgccacccc cgccgctgtc gccggaggag gaggaacagg
     6781 aggagctgct ggaactggac gagctgctgc cggaacagga actgccgccg ctggagccgc
     6841 cgccggagga cggcagcgcc agcacccggc tgacggtctc gtccgggaac gcggcgagcc
     6901 cgccgagcgc gaccagcatg gccgcgccac cgatcagtgc cagttggtcg tgatcgtccg
     6961 ccgcgggctt gcggaagacg ttggtgcgga agtggttcag cgtctgctcg cccgcgaggg
     7021 tgagccggtt catcttggtg atcagcagga ccagggccac cggcgcggtc agccccagca
     7081 acccggccag gtagccgatc ggcctgccgt tgccgacccc gtcgaccacc cgggccaccc
     7141 cgatcagcaa cagcaacccg aaggccgccg cgccgcgcag gcgggccagc gcctgccgcc
     7201 gccggggcac caccaggccc agcgtttcca gccggttgcg gacctgacca accagcgggt
     7261 ggtccgcgta cttcgcgcgc aggctgccga gggtggcagc gggggaggtg cgggcgttca
     7321 gctcggccag gatcacccgg tccagcgggt gctgggcggc caggccggtg acgctgagcc
     7381 agctgcccct ggaggcacgc aggctgcccg cctccagcat cctggccacc gcggtgaaga
     7441 ccacctggtc gccaccgcct gccaggtagg ccacatcgtc cgcgctgagc cgccccgctc
     7501 ccggggccgc ctcggcccgc cggacggacc ggcgggccca gacggccacc acgatcgaga
     7561 caagcagccc catgccgtac aggagcagga actgcgggcc ggtcaggccc caggtctcgg
     7621 tcataccccc acctcgcgtc gctcttggtt ggggcgacgg tagcgcgtca gctgccgcca
     7681 ccgccgccgc aaccaccccc gcccccacca cagccgccgc ccccgccgcc cccaccgcca
     7741 ctgtctccgc caccgccacc accggcggag aacccaccgg cgtagccccc ggccagaaaa
     7801 ccggtgtcgt tgaggccccg ggagcggcga ccgcccctgg ttccgtgcac ctgctgccgc
     7861 gccgaatgac ccagcagcgc cgaacgcacc gaggcgtccg ggtaggccgc gatgccgtcc
     7921 cgggcaacgt gttcggccgc actgtccgaa gtggacttca gtgcccgctc gaccgcggcg
     7981 tccccggcct gggtgcgcca ggccaccggc agccaggcgg cgaaggccgc cagcacaccg
     8041 gtcagcacca gcaacagcat caggtagccg accgggaagt cccggctggc gccgtcgatc
     8101 gcccgcacca cgccgagcgc gccgagcgcg atcagtggca gcgccgagcg gaaacccatg
     8161 ccgggcaacc gatccggcgg caccagcagt ccgcggtcga ccagccgggc gcccacatcg
     8221 gtgaccgcct ggctgtccgc gacccggtgc accagcaacc gcagcgtgcc gcgaccggtg
     8281 tccccggtgt actcccgcac ctgccgtgcc accgggtcct tgagcagcag cggaccggtg
     8341 ccgctgacat aaccgcccct ggcggcccgc agcgcctccc gttccagcag ccccgcgacc
     8401 acggtctcca ccgcccggga cgagcccccg accaggtacg cgagttcgac cgtggtcacc
     8461 tcgccgacct gggtggtggc gtgggcgtcc ggtcgcctcc ccgcgatccg gatccacccc
     8521 gccagcacca gcgccaccgc cagtccgacg gcgtacaact gcaagaactc cgggccggtc
     8581 agtccccatg gattgtccat cgtgaccccc tctcaccagc aaggaagcct catggtgcgg
     8641 tctgggtcac atcgggacaa gagtatttga tacaggattg ggcagaactt agggaaggct
     8701 tgagcttggc cggatttcgc tcaaccacaa cgaaatccgg ccgttacaca gctacgccga
     8761 gcggccgatc agctctcctc ggactccggg gcggcgacca ggcgcaaact gacgctgttg
     8821 atgcagtagc gctggtcggt cggcgtcggg aagccctcgc cctcgaagac gtgccccagg
     8881 tggctgtggc aggtcccgca cagcacctcg gtgcgcaccg cgcccatgct gcggtcctcg
     8941 cgcagcacga cggcctcgcc ggccagcggg gtgaagaagg acggccagcc gcagtgcgac
     9001 tcgaacttgg tgtcgctgcg gaacagttcg gccccgcacg cccggcactc gtagacgccc
     9061 gcggtcttgg tgtcggtgta ctcgccggtc cacgcccgct cggtgcccgc ctggcgcagc
     9121 acccggtact cctcgggagt gagctgctcc cgccactcct gctcggtctt gacgaccttc
     9181 ggaccctgat ccatgccacc acgctaatac gccgcgcccg ggggtgcccg tgggcggatc
     9241 tttcagaaca ggaacaacag gatggtgttg agcgcgccgg tgaaggtcag gatcaggccg
     9301 agcacgatca gcccggccag caccaccgcg gtgagcctgc ggccgccgcc gacccggttg
     9361 gccgaatcgg cgaactcgct gaccccggcc aggtagccct ccacggtgta aggcttgggc
     9421 gcgtgctcga tccggtcgag gtgctgggcg aaggcccgcg cctcgggatc gtgggggtcc
     9481 aaccccacca ggtcctcacc gaaccgccct ggcgggccct gcggctcgtc gtccggtgct
     9541 gctgcgcgca tacccgcaac ggtagcgtgc ggagctgtga acagggcaga caccgacacc
     9601 acgccgcatt atgatcccgc actcggactg gccgggctgc cgagcgcacc ccgctgggaa
     9661 tccgcaggtc agcgcagcct gtaccgcagt gactgggtca gcctggacct gatcgcggtg
     9721 cgcccgccca ccgcgccgcc ctatgagcac cacgtggtcc gcaccgccga cgcggtggcc
     9781 gtggtgctgg agcaccccga gcgcggggtg ctgatgctgc accggcaccg gttcatcacc
     9841 gagaccaccg gcctggaact cccggcgggc ggcatcgacc ctggcgagga cccggtggcc
     9901 gccgcggtcc gggagaccgc cgaggagacc ggctgggccg cggtgcgccc ccggctgttc
     9961 ctgaccaggt gcgtctccaa cggcaacagc gaccagctct tccacttcgt gcacgccgag
    10021 gtaggacagt ggctgggcgg gccggagagc cccgatgagg gccccgcggt gtgggtccgg
    10081 catgaacacc tgcgggacgt gctgggccgc gatctggtga gctgtgcgcc ctccagtctg
    10141 gggctgttgc acgcgatgac cttcggtctg ctgcgcgcgg gggccggggc cggtagcgtc
    10201 caggcccgtg agcaggggtg aagcacttga gctgaccgtg gacggcccgg cgggaccgcg
    10261 tgccgtgcgg gtgtccagcc cggacaaggt gtacttcccg gagcgcggca tcaccaagcg
    10321 ccaggtggtc gagtactacc tggcggtggc cgaaccgctg atgcgcgtgc tgggggagcg
    10381 cccgaccacg ctgaagcggt tccccgacgg cgtggcaggc gagcccttct acgccaagcg
    10441 ggtgcccaag ggcgcgccgg agtgggtgca gccggtgcgg atcaccttcc cgtccggccg
    10501 caccgccgag caggtctgcc cgaccgagcc cgcggtgctg gtctgggcgg ccaacctggg
    10561 caccctggac ttccacccgt ggccggtccg gcgacccgac gtggaccacc cggacgaact
    10621 gcggatcgac ctggacccgc agccgggcac cgacttccac gacgcggtcc gggtggcggg
    10681 cgtgctgcgc gaggtcctgg aggaggcggg catgaccggt ttcgccaaga cctccggcgg
    10741 ccgcggcatc cacgtgctgg tccgcatccg ccccgaatgg gacttcatcg aggtccggca
    10801 cgcggtgatc gcactg
//
