LOCUS       NZ_JALMDK010000003     24555 bp    DNA     linear   CON 13-SEP-2024
DEFINITION  Crossiella sp. S99.2 NODE_3_length_988117_cov_87.532730, whole
            genome shotgun sequence.
ACCESSION   NZ_JALMDK010000003
VERSION     NZ_JALMDK010000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Crossiella sp. S99.2
  ORGANISM  Crossiella sp. S99.2
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Crossiella.
REFERENCE   1  (bases 1 to 988117)
  AUTHORS   Gonzalez-Pimentel,J.L.
  TITLE     From North to South: A Spanish map of bacteria producing bioactive
            compounds in show caves
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 988117)
  AUTHORS   Gonzalez-Pimentel,J.L.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-APR-2022) Agroquimica, Microbiologia Ambiental y
            Conservacion de Suelos, Instituto de Recursos Naturales y
            Agrobiologia, Av. Reina Mercedes 10, Sevilla 41012, Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2021
            Assembly Method                   :: SPAdes v. 3.14.1
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 200x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023094165.1-RS_2024_09_13
            Annotation Date                   :: 09/13/2024 06:26:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,481
            CDSs (total)                      :: 9,422
            Genes (coding)                    :: 9,365
            CDSs (with protein)               :: 9,365
            Genes (RNA)                       :: 59
            rRNAs                             :: 2, 1 (5S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 1 (5S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 8 of 57
            Pseudo Genes (incomplete)         :: 50 of 57
            Pseudo Genes (internal stop)      :: 4 of 57
            Pseudo Genes (multiple problems)  :: 4 of 57
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:32:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 608196
            Orig. end                         :: 632751
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JALMDK010000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24555
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="3"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24555
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24555
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14555](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14555
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            114..1448
                     /locus_tag="MZC64_RS14135"
                     /old_locus_tag="MZC64_14145"
     CDS             114..1448
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1247: acetylornithine deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015103156.1"
                     /locus_tag="MZC64_RS14135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_14145"
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="WP_247756724.1"
                     /transl_table=11
                     /translation="MSEHRVAGSQRVAEDEVVSLASELIRIDSTNTGDPATLVGERAAA
                     EYVAAQLADVGFETTYVESGARGRGNVVARLAGADPSRGALLVHGHLDVVPADASEWSV
                     HPFSGAVQDGYVWGRGAVDMKDMVAMTVATARRLKRDGVVPPRDIVFAFLADEEAGGLQ
                     GAQWLVDHRPELFEGVTEAIGEVGGFSITVKDGVRAYLIETAEKGIAWMRLRVRARAGH
                     GSMVHEDNAVTKLAEAVARLGRHRFPIVMTDSVREFLAGISELTGLEFPEDDLDGTVAK
                     LGNMARMIGATLRDTANPTMLDAGYKANVIPSMAEATVDCRILPGRQAAFERELDAVLG
                     PEVEREWIASLPAVETTFDGALVDTMSASILAEDPGAKLVPYMLSGGTDAKAFSRMGIR
                     CFGFAPLRLPADLDFSALFHGVDERVPVDALQFGTRVLDRFLRNC"
     gene            complement(1473..2099)
                     /locus_tag="MZC64_RS14140"
                     /old_locus_tag="MZC64_14150"
     CDS             complement(1473..2099)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.5"
                     /locus_tag="MZC64_RS14140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_14150"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_247756723.1"
                     /transl_table=11
                     /translation="MAKPVQAVARRGETYGGRSRREREADRRERIVTAAVRLFAAREYD
                     AVTVAEVCAQAKVAKRYFYDYFTDRQELLRQVHREQNDWLLNEITTAAPKNPATLTDLL
                     APMMTTLVRRLLDHPDRARVIYLNAPRMESRRRATLRRDAELLGRLVRRIADRPPDRLR
                     HDRLLLAAVAGISEIVIDWLTRGQTDPPDPLAEHLTDLTVAILSP"
     misc_feature    complement(1614..1616)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2193..3536
                     /locus_tag="MZC64_RS14145"
                     /old_locus_tag="MZC64_14155"
     CDS             2193..3536
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010239467.1"
                     /locus_tag="MZC64_RS14145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_14155"
                     /product="MFS transporter"
                     /protein_id="WP_247756722.1"
                     /transl_table=11
                     /translation="MAAKDNRTDALLASPPGRGVSSPGGILSLLFAANLLNFYDRTIPA
                     IVVEPLKAEFLLTDTHIGVLSGAFTVVYALFGIPLGRLADRGSRRTILVTGLLFWSLLT
                     AATGLVGGFISLLVVRMLVGVGEASFAPAANSVLADLYPARRRARATALLQLGLPLGLV
                     LAFFTVGPITELSGTWRTAFFIAAVPGLFVAALMLFIREPARGAAEPVAPPPGVVAQAF
                     RKVLRIRTLWWLTLAGVGAQIAAYAVATFSVPLFQRYFGTTLATGGMLTGVVIGLTGLA
                     GLVIGGKLADRASRHSPAGRVYTGAIALLLAAPLTFAALSLGPDSVGWFVLLFSAGWLL
                     QYMYYTSVYPALADVVEPRLRATAISVFFAAFYLLGGFTGPVIAGALSDRFAAAAVGLS
                     PARAAAEGLSQSLMIVIPLGLLLTSIGLFGAARKVTADSARMRAETGG"
     misc_feature    2223..2225
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    3712..3729
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     misc_feature    3720..3738
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 20.51"
                     /tool="antismash"
     misc_feature    complement(3724..3742)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 23.9"
                     /tool="antismash"
     gene            3811..4107
                     /locus_tag="MZC64_RS14150"
                     /old_locus_tag="MZC64_14160"
     CDS             3811..4107
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MZC64_RS14150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MZC64_14160"
                     /product="hypothetical protein"
                     /protein_id="WP_247756721.1"
                     /transl_table=11
                     /translation="MPRRSAGWIWAGRVVAAVIVAGLAVYLVSVGLERADKIASVLGAL
                     AAVTALVLPYLVRPRRIEPAEPPPGAVDLRGARGVQLNQGGTNSQVNHFRDES"
     gene            complement(4127..4939)
                     /locus_tag="MZC64_RS14155"
                     /old_locus_tag="MZC64_14165"
     CDS             complement(4127..4939)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020646808.1"
                     /locus_tag="MZC64_RS14155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_14165"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_247756720.1"
                     /transl_table=11
                     /translation="MTEAEGQGSRERYRAQVREEIKQHAWRQIATAGVNALSLNAIAKQ
                     VGMSGPALYRYFASRDDLITALIRDAYQSLADTVRATDTGAANAATGTGVPIIGKGPAA
                     GPATKIGANAANADAAKANAAATTKTGTAADADTSAGANLARLAHAIRDWARADPQRYF
                     LIYGTPVPGYHAPEDTTAISAQVMAVLLDACAVLPPATTPATPFDTHLVTHREWADHPA
                     PAATLHRALSFWTRLHGVLSLELAGHFTGMKFDPDLLITDELNALLDQ"
     gene            5096..5458
                     /locus_tag="MZC64_RS14160"
                     /old_locus_tag="MZC64_14170"
     CDS             5096..5458
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020667681.1"
                     /locus_tag="MZC64_RS14160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_14170"
                     /product="hypothetical protein"
                     /protein_id="WP_247756719.1"
                     /transl_table=11
                     /translation="MTTTNPQRTRTNRTSRSVLIAAWAFPAMVLGGFALLSGIPLIVML
                     VGSLRDARLHALGWWNAAALTAYGVPLAMWLLGPSQQPSLTKYLPPVATGVVVATGVVV
                     AIAHHLRRRRSAAPGA"
     misc_feature    complement(5539..5554)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.28"
                     /tool="antismash"
     gene            5594..6529
                     /locus_tag="MZC64_RS14165"
                     /old_locus_tag="MZC64_14175"
     CDS             5594..6529
                     /EC_number="3.2.1.96"
                     /GO_function="GO:0033925 - mannosyl-glycoprotein
                     endo-beta-N-acetylglucosaminidase activity [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013227380.1"
                     /locus_tag="MZC64_RS14165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_14175"
                     /product="endo-beta-N-acetylglucosaminidase H"
                     /protein_id="WP_247756718.1"
                     /transl_table=11
                     /translation="MVKFGRITARSAALALLAAATLAAGVTAPGAAATGAAADSTAPRA
                     KNGPISVAYVEVNNNSMLNVGKYTLANGGANVFDIGVIFAANINYDTAKKSAYLHFNEN
                     VQRVLDNAATQIRPLQAKGIKVVLSVLGNHQGAGFANFPTKAAAEAFAKQLSDAVTRYG
                     LDGIDFDDEYAKYGENGTGQPNASSFVHLVTALRNTLPNKIISLYNIGPAASRLSYGGV
                     HIGTKFNYAWNPYYGTWGVPNVGLPKERLSPAAVEIGRTAASTTASLARRTKSEGYGVF
                     LTYNLGAADSASYISGFTRELYGSETRYTR"
     gene            complement(6575..9499)
                     /locus_tag="MZC64_RS14170"
                     /old_locus_tag="MZC64_14180"
     CDS             complement(6575..9499)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.5"
                     /locus_tag="MZC64_RS14170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_14180"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_247756717.1"
                     /transl_table=11
                     /translation="MASQHALYFGVLGPVAAWRGEHRIDLGWTRQQAVLAVLLLEVNRP
                     VPVSTLIDAVWGEAPPQGVRNTVQTNISRLRRALREDPAADRDGLVQRTDAGYLLRAEP
                     GQVDLVSFEQELDAARAHRRAGDLSAAATAVESALRRWRGDPFTGLDSPYLHTQRLRLA
                     ECRLAARELWAELLLGRGEHQPVVAELTGLVSAHPLRERLRELLMLALCRAGRQAEALA
                     AYQDARTTLADRLGTDPGPRLRELYQRILAADPEPCPPPAARVLAGTATRPTAPPVAAV
                     PAQLPAAVPAFTGRTTELRQLHAAAAAAADPHRQDCEIIAIDGMPGVGKTALAVQAARA
                     VAGQFPDGQIWLRLGAFATDQPPMDPREALAELLHAVGVPGAEIPECLQARAALWRACV
                     RERRLLLVFDDATGHEQLRPLLPGPGHCLVLITSRRRLTALEGPCTLELDPLPAADADT
                     LFLRLAGREQDPDPAALAELTARCGRLPLAITLLAGRLRHRPRWTLRYLLDLLASSCTM
                     LGELCAENVTLTAAFELSYRGLNPVQQRLFRSLALFPGTEIEVPAIAAMAGQDPRDIRR
                     ELEQLYDNHLLTESAPGRYAQHDLVREYARTLAEADGPAPGEAALGRLLEYYLHTTTLI
                     STRVLAAAPLTVPALPNRFAPDPAADTATDAGALAWLDRESASLIACLTSPPVRGHTAL
                     VIALTTALHPYLCSRGRWYQSISLHQTALALAQDTADEPGRAAALHHLGTLRRLTGDYP
                     GAQRDLGEALASYRALGHLRGEAGARTELGVLHTLTGDHESAATHLAAAERGHLLLNSR
                     LGLAHIQLHQGILHHRRADLPAAAASLDRAQRGYRELGNQLGQAHALTALGRLRADTGD
                     HQAAITTLTEALSGYRTLGDQLGQATTLRLLGDSHRQTGDPVAAHRHHIQALTYYTGAD
                     DPQSQAAARHHLAILHLGAGRDRETPPPPRPAPDLAQSPAVATS"
     misc_feature    complement(7040..7042)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9740..9916
                     /locus_tag="MZC64_RS14175"
                     /old_locus_tag="MZC64_14185"
     CDS             9740..9916
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038155.1"
                     /locus_tag="MZC64_RS14175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_14185"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_247756716.1"
                     /transl_table=11
                     /translation="MDAFDLDVRITTPAGADGAAGPLSIISKLACSRTPVCSKTTCQCS
                     RTCTPLCTSGSTR"
     CDS_motif       9740..9808
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MDAFDLDVRITTPAGADGAAGPL"
                     /locus_tag="MZC64_RS14175_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9809..9916
                     /prepeptide="core"
                     /locus_tag="MZC64_RS14175_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="4.40"
                     /molecular_weight="3429.0"
                     /monoisotopic_mass="3426.7"
                     /core_sequence="SIISKLACSRTPVCSKTTCQCSRTCTPLCTSGSTR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MDAFDLDVRITTPAGADGAAGPL"
                     /leader_location="[9739:9808](+)"
                     /alternative_weights="3447.0"
                     /alternative_weights="3465.1"
                     /alternative_weights="3483.1"
                     /alternative_weights="3501.1"
                     /alternative_weights="3519.1"
                     /alternative_weights="3537.1"
                     /alternative_weights="3555.2"
                     /alternative_weights="3573.2"
     gene            10001..11380
                     /locus_tag="MZC64_RS14180"
                     /old_locus_tag="MZC64_14190"
     CDS             10001..11380
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="MZC64_RS14180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_14190"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_247756715.1"
                     /sec_met_domain="LANC_like (E-value: 2.4e-45, bitscore:
                     150.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRQLSEHAAVDPGATTGTVTSWHGTVPAELADKATATALEIARRC
                     ADPERVIDLVMAAAEQAVHPNGWAYHGFAHGHAGLALLHVLTAEAAADESDRREALAAA
                     FTYIREAVAGTAGAPLTEPGVLSGTSGLALGLAACARAEPRFGPSLDRLHEQLAAQVLE
                     LPLPRVERGVSDVDYDMVSGAAGLLSYLCGIADPGPAVRAAAEHLIDYLVWLGAPPRDL
                     TLTRRWLITPDLCRGDRDYPNGHLNMGLAHGIPGPLAALATAWLAGYRQPGQEAALRLV
                     LGWVQSLRRTDEHGPVWPSEVPIDDAGAETRPSQPADQIAWCYGTAGVAVALLPVAEAL
                     GDESLRKLAVESFEAVLSRFAERPVRSPTFCHGIAGVLVLCLEFAAHGSALAADWTPRL
                     LELLLAQADPELPVLFRDEEEPGVFVDSPSLLSGSAGIALALLAATAPRRPSWFRAFLT
                     R"
     gene            11388..14555
                     /locus_tag="MZC64_RS14185"
                     /old_locus_tag="MZC64_14195"
     CDS             11388..14555
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="MZC64_RS14185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_14195"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_247756714.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 8.7e-162,
                     bitscore: 535.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.1e-13,
                     bitscore: 45.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.6e-34, bitscore:
                     114.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTESRYRATDFYLVRAPALPADTFRELLAGEGTDEQRRTVAWTRL
                     RELAATPRVRRALSVASTDLLDALDRLGPDGSGKKSKRAHSRLLRYLTRMSTRPTPFGA
                     FSGIALGEFGEHTTLRLGAPAVQRARVRADMGWLLALIKDLEQDPVLRPQLRLVRNAAA
                     HLSGDRLVLPYADIYGSGDNRAVRVRATPAVTAVLRLAATPTTADTLVAGLAQEFPEVA
                     ADRVAGLVEQLRELNFLISDLRPPQSSPFPEQHLAKRLTGIEAAAATSEALREIVDLTH
                     RAAAASDAAPLRELRAAQRALVPGHEGDSFQLDSALDLRESGLGRAVGQAVAGAMDCLM
                     RLAAALPGHNHHLVQYRDAFVERYGDQALVPVLEVLSPDTGLDAPYNYLEPPRSTPVPH
                     NTPEPSTVDYDRLLTEFAAQAWWSGEISVELTDAWLDRIAPATEKPALGLYPALDVYAQ
                     LQLTDPDGRVDDGQWRLVLRELSLAYGGRTAGRFFDLLGEDALDHLREHTRRMTSLQPE
                     AVHAELCFLPTSGRAANVAFRPLLHEYEVPVNATPSARSERTISLADLHVGVAGNRFYL
                     WSRTLGREVVVSQGHMLGPHLGPNAARFVLEVSQDGYAMPTGFRWGPLENLPFLPRVTR
                     GNVVLRPAQWTLRGEDVTGDFPAAVREWRQRWRVPRYVYLVDEDNRLLLDLDHPLGLDE
                     LAGDFRDGRGQAVLHEMLPAFDDLWLSDVDGAKYLEEIVVPVVAHSAADTARSPVPLSG
                     RLESITEVGASRSLRRRHLPGEEWAYLKVYAAFSRHDEIIAGPLRQHIAALREQGLIDR
                     WFYLRYADPQPHLRIRCRAGEPGAATEVLHQLMAWGREVVDSDLAFDTGVATYLPEIER
                     YGGPRTFEAVEDLFTVNSDVTADLVALLQRSEPKLRPEFVAIAVVDTLYRQWGLAPNER
                     PALIPPVAETEAVRKEFHAHRDYLGELVLPWDFRPHEQGRAHHDLINEILAPQAGAVAA
                     AASAVHAAMGADTLWGTESTVLGSLAHMQINRLLPVDLPREQHCYALWRHILRAVGGRP
                     AHLRGES"
     aSDomain        11859..12125
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_MZC64_RS14185_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.30E-14"
                     /identifier="RREFam001.1"
                     /label="MZC64_RS14185"
                     /locus_tag="MZC64_RS14185"
                     /protein_end="246"
                     /protein_start="157"
                     /score="45.7"
                     /tool="antismash"
                     /translation="VRNAAAHLSGDRLVLPYADIYGSGDNRAVRVRATPAVTAVLRLAA
                     TPTTADTLVAGLAQEFPEVAADRVAGLVEQLRELNFLISDLRPP"
     gene            14557..16389
                     /locus_tag="MZC64_RS14190"
                     /old_locus_tag="MZC64_14200"
     CDS             14557..16389
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="MZC64_RS14190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_14200"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_247756713.1"
                     /transl_table=11
                     /translation="MPGTKRLRDNDWLRIAAMLWRLSPVRVSALILVTFAVSVVPAVQL
                     QLTASAVQSVADAVAAGSTDGFTGRILLVGLLIVGVSVAAHLFGVWHQYLDAVLRLHLA
                     TAVGEQVMRKGTRMDLQDYENAESYDKLQRAFQESSGSNVHQLFADTLNFARELITIVS
                     VSAVLFSWHPWIALLILLAPIPSALAQMWYGKKMYEIEYDRAADRRRLMYFQFLTTTDH
                     TFKEVRLFQLGDFFIGRYRELVQRFLKVDRSLNRRQSLAFGLLGLISVLAAGGALIYAM
                     LATTRTGEIGQLAGYLQAIGVVQGSGHALLVGLAMLFQNKLFVSNLFELFDLPERQIRG
                     GQRKFPARLSTGIEFREVSFTYPGTTEQVLDRVSFTLPAGNCVALVGQNGAGKTTLVKL
                     LTRLYEPTGGEILIDGVPIQEYDLTDLRRNLGVIFQDYIRYEMSVRHNIGFGAVEHLDD
                     TGRVRAAAGASGADSIVDTLPDGYDAMLGRHFEHGSQLSGGQWQKVALARAFMRGAPVV
                     VLDEPTAAIDAEAEAEIFGRFRTIASTSTSLLVAHRFSTVRIADRIIVIEGGRLIEQGT
                     HAELMRQDGHYAYLFNLQAAGYQPEPAAEVVGPG"
     gene            16386..17345
                     /locus_tag="MZC64_RS14195"
                     /old_locus_tag="MZC64_14205"
     CDS             16386..17345
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012517.5"
                     /locus_tag="MZC64_RS14195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_14205"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_247756712.1"
                     /transl_table=11
                     /translation="MKLSLMVPVMPHEPEHLPAYAQLLVDTGAHRLWQGQSLALETFQG
                     FAYLAGRGLRVPVGTSVTLTALRHPYETALQARSLARLTGHDVVLGLGTGTPELVAALR
                     GRPYGSPLTAARDQLTILRGLLDGKPVHHDGRYDTMRGGLPEFEHPPVSLGLGVLRPGM
                     ARVAGELADAAITWLTPPSYLGEVLLPELRAAAGAAGRAAPRVVTVVQVAVRRPGRDPH
                     LVALNGSREHLAAPHYTDMLRRAGLRVHPSQVPLSARALVSSGTFVTGTVAEIAEGLDR
                     YRAAGADEVVLNTAGVHLTEGRAAALEDLGELLAALAG"
     gene            complement(17346..18092)
                     /locus_tag="MZC64_RS14200"
                     /old_locus_tag="MZC64_14210"
     CDS             complement(17346..18092)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: TauD (15-237). E-value: 6.2e-16. Score:
                     50.9. Matches aSDomain:
                     nrpspksdomains_MZC64_RS14200_TauD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014698.5"
                     /locus_tag="MZC64_RS14200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_14210"
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_247756711.1"
                     /sec_met_domain="TauD (E-value: 9.3e-15, bitscore: 50.9,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTLGIVPQRHDVNAVTEARTALATDGAVLLTGLPATADALVVAA
                     ASVLGPRLRRLFPLRERPSQDGGPVDLHADSFNLVVDLAGIPTPRRDPDEDFVFVQCVQ
                     PAPSGGDSFLADAYCFVDEHAEPELREFLTTVDVDLYGKWGAIRGVPALPRVARHVEYT
                     RTGRRIVRRTDGAVPLHRDPGAEHADRMLAAFTEAVQQIQPGLPRFRPTAGEILVVDNY
                     RCWHGRDPHPGDRLVRILTVRTADAR"
     aSDomain        complement(17382..18047)
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MZC64_RS14200_TauD.1"
                     /evalue="6.20E-16"
                     /label="MZC64_RS14200_TauD.1"
                     /locus_tag="MZC64_RS14200"
                     /protein_end="237"
                     /protein_start="15"
                     /score="50.9"
                     /tool="antismash"
                     /translation="VTEARTALATDGAVLLTGLPATADALVVAAASVLGPRLRRLFPLR
                     ERPSQDGGPVDLHADSFNLVVDLAGIPTPRRDPDEDFVFVQCVQPAPSGGDSFLADAYC
                     FVDEHAEPELREFLTTVDVDLYGKWGAIRGVPALPRVARHVEYTRTGRRIVRRTDGAVP
                     LHRDPGAEHADRMLAAFTEAVQQIQPGLPRFRPTAGEILVVDNYRCWHGRDPHPGDRLV
                     "
     gene            complement(18089..19258)
                     /locus_tag="MZC64_RS14205"
                     /old_locus_tag="MZC64_14215"
     CDS             complement(18089..19258)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017987997.1"
                     /locus_tag="MZC64_RS14205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_14215"
                     /product="MFS transporter"
                     /protein_id="WP_247756710.1"
                     /transl_table=11
                     /translation="MLRDRAFLRLWTGTTASGLATWALPFILGLAVLDRSLTAVGLGVL
                     LAARTVGFLIAVPLGGVLADRHSRRGVVLVSGLLAAAATPVIAWGLGDSLVLTATAAAL
                     VGAGQGACRPAFQALTAEVVDPDQRQQANAAMTLAVRVSTLLGPGLTALLATVLDLSAL
                     LWGTALLWLVAALLPPRGAAGTPTERTHLVREFADGLREARRHPWFLAGLGALTAVIAT
                     GYSATGVALPLISRDRYGSELVLASALTGYTAGALAGALIIARWRPRSQGWAALAGLAL
                     YGLAPLSLIADVHPAVVIAAYVVTGVGIELFNVPWFTATQREVDPRLLARVSSVDFLFS
                     YGLAPVGLALIAPAIEAFGVTAVLAGCALVCFAAPALAALAPTARRFAR"
     misc_feature    19285..19300
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.16"
                     /tool="antismash"
     misc_feature    complement(19285..19303)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.88"
                     /tool="antismash"
     misc_feature    19287..19301
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.57"
                     /tool="antismash"
     misc_feature    complement(19288..19303)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.11"
                     /tool="antismash"
     misc_feature    complement(19289..19300)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 16.9"
                     /tool="antismash"
     misc_feature    19296..19312
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.23"
                     /tool="antismash"
     gene            19373..20362
                     /locus_tag="MZC64_RS14210"
                     /old_locus_tag="MZC64_14220"
     CDS             19373..20362
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013648.5"
                     /locus_tag="MZC64_RS14210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_14220"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_247756709.1"
                     /transl_table=11
                     /translation="MSHRARLGCALAAVVAVASCAAPANAPSAGQAAVTVSSCGQQLRF
                     EHSPQRAVTLEQSSTETLLALGLGERMAGTAYRAGRILPEYQAAYDKIPVLNPKALSGE
                     QLRAAAPDLVVSSFASNFTKDKAGTRAELQALGLPSYVSAVDCPEHEPGLTPFERLFRD
                     YENYGKVFGVADRAAALTAKQREVVQQAGAVRAGRPGKPTVVYVYSVFKGLPYVAGHNG
                     MPSDMSRILNAPNAFDDINEEWPEMSWEEIAKRDPTVIVVGDLSDRGAPGDSAAEKLKM
                     MREHPVVSQLTAVRQNRIIEVPGIELDPTVRSANTLRLLGEGLKALGV"
     gene            20355..21440
                     /locus_tag="MZC64_RS14215"
                     /old_locus_tag="MZC64_14225"
     CDS             20355..21440
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005153018.1"
                     /locus_tag="MZC64_RS14215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_14225"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_247756708.1"
                     /transl_table=11
                     /translation="MSEPDLLHPAARSRPEPPLPRPRGRSGWSTTAVLLLGIVVLIVSM
                     GLAVRIGVSGVGFAEIGRTLGVRLGLPVTPLPRLLDSLIWELRVPRVLLAALVGAALAV
                     CGAALQGVTRNALADPYLLGVSNGASAGAVAVVVLGFGAGALGVTGGALAGALLSFGLM
                     LLLLRRSGMHPVRIVLTGVLVGQLFAAITSLILMASADADTTRAITYWLLGSMASARWE
                     AVLICAIAGVIGMVVIWLCATALDGFSFGSDTAASLGVNVRTTRLVLLVATALLTSVAV
                     ASVGAIGFVGLIVPHGVRFLVGPTHRVLLPVTAVAGAVFLVWTDALARIAFAPREVPVG
                     VFTALVGVPLFLLVLRRRGEL"
     gene            21437..22255
                     /locus_tag="MZC64_RS14220"
                     /old_locus_tag="MZC64_14230"
     CDS             21437..22255
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011874325.1"
                     /locus_tag="MZC64_RS14220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_14230"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_247756707.1"
                     /transl_table=11
                     /translation="MRIGVHSVSWSVPGKTIVDNVDFTVHSGQTVGLIGPNGSGKSSLL
                     RCVAGLRKPTAGVIRFDGKDIGGWTPRKIAQQLAFVEQAGDTDSDLRVAEVVALGRTPF
                     RPGWRAPGAHDHAVVEAALDRLDLIELRDRHWQTLSGGERQRAHIARALAQQPWAILLD
                     EPTNHLDIRHQLELLDLLARTEQTVLVALHDLSLAARFCDQLVLLHQGKLVAAGAPQEV
                     LTARLLREVFEVDAEVGQDSAGNLAVVYRGTADRVSPACVEPTGRGGTPR"
     gene            complement(22206..22850)
                     /locus_tag="MZC64_RS14225"
                     /old_locus_tag="MZC64_14235"
     CDS             complement(22206..22850)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018680400.1"
                     /locus_tag="MZC64_RS14225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_14235"
                     /product="response regulator transcription factor"
                     /protein_id="WP_308301004.1"
                     /transl_table=11
                     /translation="MNKPIGLLVVDDHPVVRDGLTGMFARDPEFAVLGEAADGAEAVRL
                     ARRLRPDVILMDLRMPGLDGVSAIRELAGQAPECRVLVLTTYDTDSYVLPAIEAGATGY
                     LLKDAPRDELLRAVRAAARGEPVLAPSVAALLMNRVRKPAPGPLSPREVEVLELVAGGA
                     TNRAAAAELFLTEATVKSHLLNIYAKLGVNDRAAAITEAFHRGLLVPRKQD"
     gene            complement(22847..24088)
                     /locus_tag="MZC64_RS14230"
                     /old_locus_tag="MZC64_14240"
     CDS             complement(22847..24088)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020667503.1"
                     /locus_tag="MZC64_RS14230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_14240"
                     /product="sensor histidine kinase"
                     /protein_id="WP_247756706.1"
                     /transl_table=11
                     /translation="MSEPVPRWSLVTSAGPYALLAFLAVITVPIKHKIGESPVPDLLVC
                     ALLAAWMLGMFTLRPAWRTNAPRMAVFVAGVVLCSLFLVVSSPWFGFLSPVGYLYALRL
                     LRWPWQLAGVAGVAVAAGTAQASGVDKSTAFGVLIYLAVLAANVLPMCGYAAFARRAAR
                     KEEEREHALGEAREANRRLAASLAENAALHEQLLTQARDAGVREERQRMAREIHDTLAQ
                     GLTGIISQLRAADTTDPAACRKHVAAADKLARESLTEARRSVHALRPEPLRVARLSEAL
                     AGVAQRWSALHEIPVRVTTTGAARPIRPEAEAALLRIAQEALANVAQHARAGRVGLTLS
                     YLEQEAALDIRDDGDGFDPARIEDPRPDRGGFGLIAMRQRVTELSGTLQVESEPGLGTG
                     ISARVPLELAEVCA"
     misc_feature    complement(24105..24123)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.07"
                     /tool="antismash"
     misc_feature    24204..24220
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.37"
                     /tool="antismash"
ORIGIN
        1 ccggacttgg cggtgtcccg ccaggcagga gaaggttagc tgatcaactg gcgcgggtcc
       61 aaatcagctg ggatgggcgg gtctggtggg ggttgcggtg atagaaaggc ctggtgagcg
      121 agcatcgggt agccgggagt cagcgggtcg ccgaggacga ggtggtcagc ctcgccagtg
      181 agttgattcg gatcgacagc accaatacgg gggatcctgc cactctcgtg ggtgagcggg
      241 cggcggcgga gtatgtcgcc gcgcagctgg ccgatgtggg gttcgagacg acctatgtcg
      301 agtcgggggc ccgggggcgg gggaacgtgg tggcccggtt ggccggggct gatcccagcc
      361 ggggggcgtt gctggtgcat gggcatctgg atgtggtgcc ggctgatgct tccgagtggt
      421 ctgtgcatcc gttctcgggg gcggtgcagg acgggtatgt gtgggggcgg ggggctgttg
      481 acatgaagga catggtggcc atgacggtgg ccaccgcgcg gcggttgaag cgggacgggg
      541 tggtgccgcc gcgggacatc gtgttcgcgt tcctggctga tgaggaggcc ggtgggctgc
      601 agggcgcgca gtggctggtg gatcatcggc cggagttgtt cgagggggtt accgaggcca
      661 ttggggaggt cggcgggttc tcgatcactg tcaaggacgg ggttcgggcc tatctgatcg
      721 agaccgcgga gaagggcatt gcctggatgc ggttgcgggt tcgggcccgc gcggggcacg
      781 ggtcgatggt gcatgaggac aacgcggtca ccaagctggc ggaggcggtg gcgcggttgg
      841 ggcggcatcg gttcccgatc gtgatgacgg attcggtgcg ggagttcctg gccgggatca
      901 gtgagctgac ggggctggag ttcccggagg acgatctcga tgggaccgtg gcgaagctgg
      961 ggaacatggc ccggatgatc ggggcgacct tgcgggacac ggcgaatccg acgatgttgg
     1021 acgccgggta caaggccaac gtcatcccga gcatggccga ggccacggtg gactgccgga
     1081 tcctgccggg acgccaggcg gcgttcgagc gggaactgga cgcggtgctc gggccggagg
     1141 tggagcggga gtggatcgcg agtctgcccg cggtggagac gaccttcgac ggggcgctgg
     1201 tggacaccat gtcggcctcg atcctggccg aggatccggg ggcgaagctg gtgccctaca
     1261 tgctctccgg cggtacggac gcgaaggcgt tcagccggat ggggattcgc tgcttcgggt
     1321 tcgcgccgtt gcggttgccg gcggatctgg acttctccgc gctcttccac ggggtggacg
     1381 agcgggtgcc ggtggacgcg ctgcagttcg gcacccgggt gctggaccgg ttcctgcgca
     1441 actgctgagc agggtgggaa cggtggcgtt cctcatggac tgaggatcgc caccgtgagg
     1501 tcggtgaggt gttcggccag cgggtcgggt gggtccgtct ggccgcgggt gagccagtcg
     1561 atgacgattt cgctgatgcc ggcgaccgcg gccagcagca ggcggtcgtg gcgtaaccgg
     1621 tcgggtgggc ggtccgcgat ccggcggacc aggcggccca gcaactcggc gtcgcggcgc
     1681 agggtggccc ggcggcggga ctccatccgc ggggcgttga ggtagatgac cctggcccgg
     1741 tccgggtggt ccagcaggcg gcgcaccagg gtggtcatca tcggggcgag caggtcggtc
     1801 agggtcgccg ggttcttggg ggcggcggtg gtgatctcgt tgagcagcca gtcgttctgc
     1861 tcgcggtgga cctggcggag cagctcctgg cggtcggtga agtagtcgta gaagtagcgc
     1921 ttggccacct tcgcctgcgc gcacacctcg gccaccgtca ccgcgtcgta ctcccgggcg
     1981 gcgaagagcc ggaccgcggc ggtgacgatc cgctcccgcc ggtcggcctc gcgttcccgc
     2041 cgggaccgac cgccgtaggt ctcgccccgc ctggccactg cctgcactgg tttggccact
     2101 tttcgccctt acctggatgc ctgtccatcg cctacgttag tcctccccac gcagtgcgga
     2161 acgacgatgt tccagatgca cttggaggaa ccatggcggc gaaggacaac cggaccgacg
     2221 ctttactcgc cagcccgccg ggccgggggg tgtccagccc cgggggcatc ctcagtctgc
     2281 tgttcgcggc caacctgctc aacttctacg accggaccat cccggccatc gtggtggagc
     2341 cgctcaaggc cgagttcctc ctgaccgaca cccacatcgg cgtgctcagc ggcgcgttca
     2401 ccgtggtcta cgcgctgttc ggtatcccgc tgggccggct ggccgaccgc ggttcgcggc
     2461 gcaccatcct ggtcaccggg ctgcttttct ggagcctgct caccgcggcg accggcctgg
     2521 tgggcgggtt catcagtctg ctggtggtgc ggatgctggt cggggtgggt gaggcgagct
     2581 tcgcgccggc ggccaactcg gtgctggccg acctctatcc ggcgcggcgc cgggcccgcg
     2641 ccaccgcgtt gctgcagctc gggttgccgc tggggctggt gctggccttc ttcacggtcg
     2701 ggccgatcac cgagctgtcc ggcacctggc gcaccgcgtt cttcatcgcc gccgtgccgg
     2761 ggctgttcgt cgcggcgctg atgctgttca tccgcgaacc cgcccgcggc gccgccgaac
     2821 cggtcgcgcc gccgccgggt gtggtggccc aggccttccg caaggtgctg cggatccgga
     2881 cgctgtggtg gctgaccctg gccggggtcg gcgcgcagat cgcggcctat gcggtggcga
     2941 ccttcagcgt gccgctgttc cagcgctact tcggcaccac cctggccacc ggcggcatgc
     3001 tcaccggcgt ggtgatcggc ctgaccgggc tggctggact cgtcatcggc ggcaagctcg
     3061 ccgaccgggc cagccgccac tcccccgccg gccgcgtcta caccggcgcg atcgcgctgc
     3121 tgctggccgc gccgctgacc ttcgccgcgc tctccctggg cccggactcg gttggctggt
     3181 tcgtgctgct gttctcggcg ggctggctgt tgcagtacat gtactacacc tcggtctacc
     3241 cggcgctggc cgatgtggtc gagccgcggt tgcgggccac cgcgatctcg gtcttcttcg
     3301 ccgccttcta cctgctgggc gggttcaccg ggccggtgat cgcgggtgcg ctctcggacc
     3361 ggttcgccgc ggcggcggtc gggctgagcc cggcgcgggc ggcggcggag gggctgagtc
     3421 agagcctgat gatcgtgatc ccgctgggtc tgctgctgac ctcgatcggg ctgttcggcg
     3481 cggcgcgcaa ggtcaccgcg gacagcgcgc ggatgcgggc cgagaccggg ggctgagccg
     3541 gcggagggac gcccggccgg cgcgcggcgg tgcgccggtg ccgggcgtcc gcaccgcctg
     3601 accgcaggac ggcggcggtt ttgacgccca ggcgcgatgg aggcgacaac cgcgtccagc
     3661 gagcgtcaag ccctgcgggc agatccaggg tgcttcggca tcaggtgaac aactccctga
     3721 ttgcggatac tgtatgccgc ttggcaacca cgcgggcgga tctgcccgca aggggcagca
     3781 aagcaggccc gaagtgtcat gctgggagcc atgccgaggc gtagcgctgg atggatctgg
     3841 gcgggccggg tggtcgccgc ggtgatcgtg gccgggctgg cggtctacct ggtgtcggtc
     3901 gggctggagc gggcggacaa gatcgccagc gtgctcgggg ccttggccgc ggtgaccgcg
     3961 ctggtgctgc cgtacctggt gcggccacgg cggatcgagc cggccgagcc gccgccgggc
     4021 gcggtcgacc tgcgcggggc tcgtggggtg cagctcaatc agggcgggac gaacagccag
     4081 gtcaaccact tccgcgacga gtcctgaccg gggcgcgcgg gcggggtcac tggtcgagca
     4141 gggcgttgag ttcgtcggtg atcagcaggt cggggtcgaa cttcatgccg gtgaagtggc
     4201 cggcgagttc cagggagagc acgccgtgca ggcgggtcca gaaggacagc gcgcggtgca
     4261 gggtggcggc cggggccggg tgatcggccc actcgcggtg ggtcaccagg tgggtgtcga
     4321 agggggtggc cggggtggtt gccggcggga ggacggcgca ggcgtccagc agcacggcca
     4381 tgacctgggc ggagatcgcg gtggtgtcct cgggggcgtg gtagccgggg accggggtgc
     4441 cgtagatgag gaagtagcgc tgggggtcgg cgcgggccca gtcgcggatg gcgtgggcca
     4501 gtcgggccag gttggcaccg gcgctggtgt cggcgtcggc ggcagtgccg gttttggtgg
     4561 tggcagcggc gttggctttc gcggcgtcgg cgttggcggc gttggcaccg atcttggtgg
     4621 ccgggccggc ggcggggccc ttgccgatga tggggacgcc tgtgccggtg gcggcgttgg
     4681 cggcgcccgt gtcggtggcg cggacggtgt cggcaaggct ttggtaggcg tcccggatca
     4741 gcgcggtgat caggtcgtcg cggctggcga agtagcggta cagggcgggg ccgctcatgc
     4801 cgacctgttt ggcgatcgcg ttgagggaca acgcgttcac ccccgcggtg gcgatctgcc
     4861 gccaggcgtg ctgcttgatc tcctcgcgta cctgtgcccg gtagcgctcc cgggagccct
     4921 gaccctcggc ctcggtcatc ggctgctcct tcctggtcgg tgtgacgccg tcgaagtcta
     4981 gttagagcct ctcactttag ctattgacgc tcacggcttg cgcgttatag cttctaacta
     5041 acgcgagagt ggctaaccgg ccccggtaga gcagccgagt gagcaggagc agacgatgac
     5101 caccaccaac ccgcagcgca cccgcacgaa ccgcacctcg cggtcggtcc tcatcgcggc
     5161 ctgggccttc ccggccatgg tgctcggcgg attcgcactg ctctccggca tcccgctgat
     5221 cgtcatgctg gtcggcagcc tgcgcgacgc ccggctgcac gcactcggct ggtggaacgc
     5281 cgccgcgctc accgcctacg gcgtgccgct ggcgatgtgg ctgctcgggc cgagccagca
     5341 gccgagcctg accaagtacc tgccgccggt cgccacggga gtcgtggtgg cgaccggggt
     5401 agtggtggcc atcgcgcatc acctgcggcg caggcgctcc gcggccccgg gcgcctgaac
     5461 gccgcacgcg ggctggcgtc cgtattcggg ctggcctccc cactaatgag ggtggcccag
     5521 accagcatcg ccgctgatag ttgcctggac cagtaccgat ccagcagctc aggcgacggg
     5581 agtttgatca acgatggtca agttcggtcg gatcaccgcg cggtcggccg cgctcgcact
     5641 cctggccgcg gccacgctcg cggccggggt gaccgcaccc ggggccgcgg cgaccggcgc
     5701 cgccgcggac agcacggcgc cacgggccaa gaacgggccg atctcggtgg cctatgtcga
     5761 ggtcaacaac aacagcatgc tcaacgtcgg caagtacacg ctggccaatg gcggcgccaa
     5821 cgtgttcgac atcggcgtca tcttcgccgc caacatcaac tacgacaccg cgaagaagtc
     5881 cgcctacctg cacttcaacg agaacgtgca gcgggtgctg gacaacgcgg ccacccagat
     5941 ccggccgttg caggccaagg gaatcaaggt ggtgttgtcc gtgctgggca atcaccaggg
     6001 cgccgggttc gcgaacttcc cgaccaaggc ggcggctgag gcgtttgcca agcagctctc
     6061 cgacgcggtg acgcggtatg ggctggatgg cattgacttc gatgacgagt acgccaagta
     6121 cggcgagaat ggcaccgggc agcccaacgc cagttcgttc gtgcacctcg tcaccgcgct
     6181 gcgcaacacc ctgcccaaca agatcatctc gctgtacaac atcggtccgg cggcctcccg
     6241 gctctcctac ggcggggtgc acatcggcac caagttcaac tacgcctgga acccgtacta
     6301 cgggacctgg ggcgtgccga acgtcggtct gcccaaggaa cgcctctccc ccgccgccgt
     6361 ggagatcggc cggaccgcgg cgagcaccac ggccagcctg gcccggcgca ccaagagcga
     6421 gggctacggc gtgttcctga cctacaacct gggcgccgcc gactcggcga gctacatctc
     6481 cggcttcacc agggagctgt acggcagcga gacccggtac acccggtagc ggcaacgtgg
     6541 tgggcgggcc tgtcccgccc accacggcac cgggtcagga ggtggccacc gcgggtgact
     6601 gggcgaggtc gggggccggc cggggcggcg gtggggtttc ccggtcccgg cccgcgccca
     6661 ggtgcaggat ggccaggtgg tggcgggcgg ctgcttggct ctgcgggtca tcggcgccgg
     6721 tgtagtaggt cagggcctgg atgtggtggc ggtgtgcggc aacgggatcg ccggtctggc
     6781 ggtggctgtc gccgagcagg cgcagggtgg tggcctggcc gagttggtcg ccaagggtgc
     6841 ggtagccgga cagggcctcg gtcagcgtgg tgatggccgc ttggtggtcg ccggtgtcgg
     6901 cgcggagtcg gcccagggcg gtgagcgcgt gcgcttggcc gagttggttg cccagttccc
     6961 ggtagccgcg ctgggcgcgg tcgagactgg ccgcggcggc gggcaggtcg gcgcgccggt
     7021 ggtgcaggat gccttggtgt aactggatgt gggccaggcc gagtctgctg ttgagcagca
     7081 ggtggccgcg ctcggcggcg gcgaggtggg tggcggcgga ctcgtggtcg ccggtgagcg
     7141 tgtgcagcac gccgagttcg gtgcgggcgc ctgcctcgcc gcggaggtgc ccgagggcgc
     7201 ggtagctcgc cagggcttcg ccgagatcgc gttgtgcgcc cgggtagtcg ccggtgagcc
     7261 gccgcaacgt gccgaggtgg tgcagggcgg cggcgcggcc gggttcgtcg gcggtgtcct
     7321 gggccagggc cagtgcggtc tggtgcaggc tgatcgactg gtaccagcgg ccgcggctgc
     7381 acaggtaggg gtgcagggcg gtggtgagcg cgatgaccag ggcggtgtgc ccgcggaccg
     7441 gtgggctggt caggcaggcg atcaggctag cgctttcccg gtccagccag gcgagcgcgc
     7501 ccgcgtcggt ggcggtgtcc gcggcggggt cgggggcgaa ccggttgggc agggcgggca
     7561 cggtcagtgg cgctgccgcg agcacccggg tgctgatcag ggtggtggtg tgcaggtagt
     7621 actccagcag ccggccgagc gcggcctccc ccggcgcggg gccgtcggct tcggcgaggg
     7681 tgcgggcgta ctcccggacc aggtcgtgct gcgcgtaccg gccgggcgcg gattcggtga
     7741 gcaggtggtt gtcgtagagc tgctccagtt cgcgccggat gtccctcggg tcctgaccgg
     7801 ccatcgcggc gatggcgggc acctcgatct cggtgccggg gaacagggcc agggaccgga
     7861 acagccgctg ctgcaccggg ttgaggccgc gataggacag ctcgaacgcg gcggtaagcg
     7921 tgacgttctc cgcgcacagc tcgccgagca tggtgcagga ggaggccagc aggtccagca
     7981 ggtaccgcag tgtccatcgt ggacggtgcc gcaatcgccc ggccagcaag gtgatcgcca
     8041 gtggcagccg tccgcagcgc gcggtgagtt cggccagcgc ggccggatcc gggtcctgct
     8101 cgcggccggc caggcgcagg aacagggtgt ccgcgtccgc ggcgggcagc gggtcgagtt
     8161 ccagggtgca cgggccttcc agcgcggtga gcctgcggcg gctggtgatc aggaccaggc
     8221 agtgccccgg gccgggcagc agcggccgga gttgttcgtg gccggtggca tcgtcgaaga
     8281 ccagcagcag ccgccgctcg cgcacgcagg cccgccacag cgcggcgcgg gcctgcaggc
     8341 actcggggat ctccgcaccg ggcacgccca cggcgtgcag cagttcggcg agtgcttcgc
     8401 gggggtccat cggcggctgg tcggtggcga acgcgcccag ccgcaaccag atctggccgt
     8461 cggggaattg tccggccacc gcgcgggcgg cctgcacggc gagcgcggtc ttgcccacgc
     8521 ccggcatgcc gtcgatggcg atgatctcgc agtcctgccg gtgcggatcg gccgcggcgg
     8581 ccgcggccgc gtgcagctgc cgcagttccg tggtgcgacc ggtgaaggcg ggcaccgcgg
     8641 cgggcagctg cgcgggcacg gcggctactg gcggggcggt cggccgggtg gctgtaccgg
     8701 ccagcacccg ggccgccggg ggtgggcagg gttccgggtc ggcggccagg attcgttggt
     8761 acagctcgcg tagtcgcggt ccggggtcgg tgccgagccg gtcggccagg gtggtccgcg
     8821 cgtcctggta ggcggccagc gcctcggcct gccggcccgc ccggcacagc gcgagcatca
     8881 gcaactcccg caaccgttcc cgcagtgggt gcgcgctgac caggccggtc agctcggcca
     8941 ccaccggctg gtgctcaccg cggcccagca gcagttccgc ccacagttcc cgggcggcca
     9001 gccggcattc ggccagccgc agccgctggg tgtgcaggta cgggctgtcc aggccggtga
     9061 acgggtcgcc gcgccagcgc cgcagcgccg actccaccgc ggtggccgca gcactgaggt
     9121 ccccggcccg ccggtgtgcc cgcgccgcgt ccagctcctg ctcgaaggag accaggtcca
     9181 cctggcccgg ttcggcgcgc agcaggtagc cggcgtcggt gcgctgcacc aggccgtccc
     9241 ggtccgcggc cggatcctct cgcagggccc ggcgcaaccg gctgatgttg gtctgcacgg
     9301 tgttgcgcac gccctgcggc ggcgcctcgc cccacaccgc gtcgatcagc gtgctcaccg
     9361 gcaccggccg gttcacctcc agcagcagca ccgcgagcac ggcctgttgc cgggtccagc
     9421 ccaggtcgat ccggtgttct ccgcgccagg cggccaccgg acccagaacg ccgaagtaca
     9481 gcgcgtgttg cgatgccaca gccacccccc agttcgtgcc cgtgatcacg ccaccgtagc
     9541 cgcgaggacc cgttctggca gctggttggc ccggctgaac tgctcgtcca gcgcgctgac
     9601 agggctgtga cagcgctgtg tacgcgaccg tcagaaccgc gtacgccgcc ggttctacgt
     9661 tgtgccgagg cgctgcgaat aacgcagatc cgcaccggtc gattccggcc ggtgaattcg
     9721 ccgaatagga gacgaacaca tggacgcatt cgatctggac gtccggatca ccaccccggc
     9781 cggagccgac ggggccgccg ggccgctgtc gatcatcagc aagctggcct gctcgcgcac
     9841 cccggtctgc tccaagacga cctgccagtg cagccgcacc tgcacgccgc tctgcacctc
     9901 gggcagcacg cgctgaggaa agggtgctgc cgtgtgtgga agacacggca gcacccactc
     9961 gccaaattac cgcattcctt tccacaaatt gggggtattc gtgcgccagt tgtccgagca
    10021 cgccgcggtt gacccgggcg ccacgaccgg cacggtgacc agctggcacg gcacggttcc
    10081 ggcagaattg gccgacaagg ccaccgcgac cgcgctggag atcgcgcgtc gttgcgccga
    10141 tccggagcgg gtcatcgacc tggtcatggc cgccgccgag caggccgtgc accccaacgg
    10201 ctgggcctat cacggcttcg cgcacgggca cgccggactc gcgctgctgc acgtgctcac
    10261 cgccgaagcg gccgccgacg agtccgatcg ccgcgaggcc ctggccgccg cgttcaccta
    10321 catccgggag gcggtggccg gtaccgcggg cgccccgctg accgaacccg gcgtgctctc
    10381 cggcaccagc ggactcgcgc tgggcctggc cgcctgcgcg cgggccgagc cgcggttcgg
    10441 cccgagcctg gaccggttgc acgaacagct ggccgcccag gtcctggagc tgccgttgcc
    10501 gcgggtggag cgcggggtga gcgatgtcga ctacgacatg gtcagcggcg ccgcgggcct
    10561 cctgtcctac ctgtgcggca tcgccgatcc cggtccggcc gtgcgcgccg cggccgagca
    10621 cctcatcgac tacctggtgt ggctgggcgc tcccccgcgc gatctcacgc tgacccgccg
    10681 ctggctgatc acccccgacc tgtgccgcgg cgaccgcgac taccccaacg gccacctcaa
    10741 catgggcctg gcgcacggca tccccggccc gctggccgcg ctggccaccg cctggctggc
    10801 cggctaccgg cagcctgggc aggaggccgc gctgcgcctg gtgctgggct gggtgcagag
    10861 cctgcgccgc accgacgaac acggcccggt ctggcccagc gaggtgccca tcgacgacgc
    10921 cggcgccgag acccggccca gtcagcccgc ggaccagatc gcctggtgct acggcaccgc
    10981 cggggtggcc gtcgcgctgc tcccggtggc cgaggcgctg ggcgatgagt cgctgcgcaa
    11041 gctggccgtc gagtccttcg aggccgtgct gagccgcttc gccgagcgcc cggtgcgctc
    11101 ccccaccttc tgccacggca tcgccggggt gctggtgctg tgcctggaat tcgccgcgca
    11161 cggcagcgcg ctcgccgccg actggacgcc ccggttgctg gagttgttgc tggcccaggc
    11221 cgatccggag ctgccggtgc tgttccgcga cgaggaggag cccggggtgt tcgtggacag
    11281 tccgtcgttg ctgtccgggt cggccgggat cgcgctggcc ctgctggccg cgaccgcgcc
    11341 gcgccgtccg tcctggttcc gcgccttcct cacgaggtga gcccccgatg accgagtccc
    11401 gttaccgcgc gaccgatttc tacctggtgc gcgcgcccgc gctgcccgcg gacaccttcc
    11461 gcgagctgct ggccggcgag ggcaccgacg agcagcgccg caccgtggcc tggacccggc
    11521 tgcgcgagct ggccgcgacg ccgcgggtgc gccgggcgct gtcggtggcc agcaccgacc
    11581 tgctggacgc gctggaccgg ctcggccccg acggcagtgg caagaagagc aaacgggcgc
    11641 actcccggct gttgcgctat ctgacccgga tgtccacccg ccccaccccg ttcggcgcct
    11701 tctccggcat cgcgctgggc gagttcggcg agcacaccac gctccggctc ggcgcgcccg
    11761 cggtgcagcg agcccgggtg cgggccgata tgggctggct gctggcgctg atcaaggacc
    11821 tggaacagga tccggtgctg cgcccgcagt tgcggctggt ccgcaacgcc gccgcgcacc
    11881 tgagcgggga ccggctggtg ctgccctacg ccgacatcta cggcagcggc gacaaccgcg
    11941 ccgtgcgggt acgggctact cccgcggtca ccgcggtgct gcggctggcc gccaccccga
    12001 ccacggccga cacgctggtc gccggactcg cccaggagtt cccggaggtg gccgcggacc
    12061 gggtcgccgg gctggtggaa cagttgcggg aactgaactt cctcatcagc gacctgcgcc
    12121 cgccgcagtc cagtccgttc ccggaacagc acttggccaa gcggctcacc gggatcgagg
    12181 ccgccgcggc cacgagcgag gcactgcgcg agatcgtcga cctcacccac cgggccgccg
    12241 ccgcgagcga cgccgcgccg ctgcgggagt tgcgggccgc ccagcgcgcg ctggtgccag
    12301 gacacgaggg cgactccttc cagctggact ccgcgctgga cctgcgcgag tccgggctcg
    12361 gccgggcggt cgggcaggcc gtggccgggg cgatggactg cctgatgcgg ctggccgccg
    12421 cgctgccggg gcacaaccac cacctggtgc agtaccggga cgccttcgtc gagcgctacg
    12481 gcgatcaggc cctggtcccg gtgctggagg tgctcagccc ggacaccggc ctggacgcgc
    12541 cgtacaacta cctcgaacca ccgcggtcca ccccggtgcc gcacaacact cccgaaccgt
    12601 ccacagtgga ctatgaccgg ctgctgaccg agttcgccgc gcaggcctgg tggtccggcg
    12661 agatctcggt ggaactcacc gacgcctggc tggaccggat cgccccggcc accgagaaac
    12721 ccgcgctggg cctctacccc gcgctggatg tctacgcgca actccagctc accgacccgg
    12781 acggccgggt ggacgacggg cagtggcggc tggtgctgcg cgaactcagc ctggcctacg
    12841 gcgggcgcac cgcagggcgc ttcttcgacc tgctcggcga ggacgccctg gaccacctgc
    12901 gcgagcacac ccggcggatg accagcctgc aacccgaggc ggtgcacgcc gaactgtgct
    12961 tcctgcccac ctccgggcgg gcggccaacg tggcgttccg gcccttgctg cacgagtacg
    13021 aggtgccggt caacgccacg ccctcggccc gctccgaacg caccatcagc ctggccgacc
    13081 tgcacgtggg cgtggccggg aaccggttct acctgtggtc gcgcaccctg ggccgggagg
    13141 tggtggtctc gcaggggcac atgctcggcc cgcacctggg gcccaacgcg gcccggtttg
    13201 tgctggaggt ctcccaggac ggttacgcca tgcccaccgg tttccgttgg ggcccactgg
    13261 agaacctgcc gttcctgccc agggtcaccc gcggcaacgt ggtgctgcgg ccggcgcagt
    13321 ggacgctgcg cggcgaggat gtcaccgggg atttcccggc cgcggtcagg gaatggcggc
    13381 agcgctggcg ggtgccgcgg tacgtctacc tggtcgatga ggacaaccgg ctgctgctcg
    13441 acctggatca cccgctgggt ctggacgagc tggccggtga cttccgggac gggcgcggcc
    13501 aggcggtgct gcacgagatg ctgcccgcct tcgacgacct gtggctgtcc gatgtggacg
    13561 gtgcgaagta cctggaggag atcgtggtgc cggtggtggc gcattcggcc gcggacaccg
    13621 cgcgcagccc ggtgccgctc tccggcaggc tggagtcgat caccgaggtc ggcgccagcc
    13681 gcagtctgcg gcgacggcac ctgcccggcg aggaatgggc ctacctcaag gtgtacgcgg
    13741 ccttcagcag gcacgatgag atcatcgccg gaccgctgcg gcaacacatc gcagccctgc
    13801 gcgaacaagg tctgatcgac cgctggttct atctgcgtta cgccgatccc cagccacacc
    13861 tgcggatccg ctgccgggca ggcgaaccgg gcgcggccac cgaggtgctg caccagctga
    13921 tggcctgggg ccgcgaggtg gtggacagtg acctggcctt cgacaccggg gtggcgacct
    13981 acctgccgga gatcgagcgc tacggcgggc cgcggacctt cgaggcggtg gaggacctct
    14041 tcaccgtcaa cagcgacgtc accgccgacc ttgtcgccct gttgcagcgg agcgaaccca
    14101 agctgcgccc ggagttcgtg gcgatcgccg tggtggacac gctctaccgg cagtggggcc
    14161 tggcgccgaa cgagcgtccg gcgctgatcc cgccggtggc cgagaccgag gcagtgcgca
    14221 aggagttcca cgcccaccgc gactacctcg gtgaactggt gctgccgtgg gatttccggc
    14281 cgcacgagca gggccgggcg caccacgacc tgatcaacga gatcctcgcc ccgcaggccg
    14341 gggcggtggc cgcggcggcg tcggcggtcc acgcggcgat gggcgcggac acgttgtggg
    14401 gcaccgaatc cactgtgctg ggcagcctgg cgcacatgca gatcaaccgg ttgctgccgg
    14461 tggacctgcc gcgggagcag cactgctacg cgctgtggcg gcacatcctg cgcgcggtcg
    14521 gcggtcgccc ggcgcacctc cgaggggagt cctgagatgc cggggacaaa gcggttgcgg
    14581 gacaacgact ggctgcgcat cgcggccatg ctgtggcggc tgagcccggt gcgggtgagc
    14641 gcgctgatcc tggtgacctt cgcggtgtcg gtggtgcccg cggtgcagct ccagctcacc
    14701 gcgagcgcgg tgcagtcggt ggccgacgcg gtcgccgcgg gcagcaccga cgggttcacc
    14761 gggcggattt tgttggtggg cctgctgatc gtgggggtca gtgtcgccgc gcacctgttc
    14821 ggggtgtggc accagtacct ggacgcggtg ctgcgcctgc acctggccac cgcggtcggt
    14881 gagcaggtga tgcgcaaggg cacccggatg gatctgcagg actacgagaa cgccgagtcc
    14941 tacgacaagt tgcagcgggc cttccaggag agcagcgggt ccaacgtcca ccagcttttc
    15001 gccgacacgc tcaacttcgc ccgcgagctg atcaccatcg tgtcggtctc cgcggtgctg
    15061 ttctcctggc acccgtggat cgcgctgctg atcctgctgg cgccgatccc ctccgcgctg
    15121 gcgcagatgt ggtacggcaa gaaaatgtac gagatcgagt acgaccgggc cgcggaccgg
    15181 cggcggctga tgtacttcca gttcctcacc accaccgacc acaccttcaa ggaagtccgg
    15241 ctgttccagc tcggcgactt cttcatcggc cggtaccggg aactggtgca gcgcttcctc
    15301 aaggtggacc gctcgctcaa ccgcaggcag tcactggcct tcggactgct cggcctgatc
    15361 agcgtgctgg ccgcgggcgg ggcgctgatc tacgcgatgc tggccaccac gcgcaccggc
    15421 gagatcggtc agctcgcggg ttatctgcag gcgatcggtg tggtgcaggg gtcggggcac
    15481 gcgctgctgg tcgggctggc gatgctgttc cagaacaagc tgttcgtgag caacctgttc
    15541 gagctgttcg acctgccgga gcgacagatc cggggcgggc aacggaaatt ccccgcgcgg
    15601 ctgagcacgg gaatcgagtt ccgggaggtc agcttcacct accccggcac caccgaacag
    15661 gtcctcgatc gggtcagttt caccctgccc gccgggaact gcgtggcgct ggtcggccag
    15721 aacggggcgg gcaagaccac cctggtgaag ctgctgaccc ggctgtacga gccgaccggc
    15781 ggggagatcc tgatcgacgg ggtgccgatc caggagtacg acctgaccga cctgcgccgc
    15841 aacctgggag tgatcttcca ggactacatc cgctacgaga tgagcgtgcg gcacaacatc
    15901 gggttcggcg cggtggaaca cctcgacgac accggccggg tccgcgcggc cgccggggcc
    15961 agtggcgcgg attccattgt ggacactctg ccggatggct atgacgccat gctgggcagg
    16021 catttcgagc acggcagcca gctctccggc gggcagtggc agaaggtggc cctggcgcgg
    16081 gcgttcatgc gcggcgcgcc ggtggtggtg ctggacgagc cgaccgcggc catcgacgcc
    16141 gaggcggagg cggagatctt cggccgcttc cgcaccatcg ccagcacctc cacgagtttg
    16201 ctggtggcgc accggttctc caccgtgcgc atcgcggacc ggatcatcgt catcgagggc
    16261 ggccggctga tcgaacaggg cacgcacgcc gagttgatgc gccaggacgg gcactacgcc
    16321 tacctgttca acctgcaggc cgccggatac cagccggaac cggccgccga ggtggtcggg
    16381 cccggatgaa actctcgctg atggtgccgg tcatgccgca cgagcccgaa cacctgcccg
    16441 cctacgccca actgctcgtc gacaccggcg cgcaccggtt gtggcagggc cagtcgctgg
    16501 ccctggagac cttccagggc ttcgcctacc tggccgggcg cggcctgcgg gtgccggtcg
    16561 gcaccagcgt caccctcacc gccctgcgcc acccgtacga gacggcgttg caggcccgct
    16621 cgctggctcg gctcaccggg catgacgtgg tgctgggcct gggcaccggc accccggagc
    16681 tggtggcggc gctgcgcggg cggccctacg gcagtccgct gaccgcggcc cgcgaccagc
    16741 tcaccatcct gcgcggcctc ctggacggca aacccgtgca ccacgacggc cgctacgaca
    16801 cgatgcgcgg cgggctgccg gagttcgagc atccgccggt gtccctgggg ctgggggtgt
    16861 tgcggcccgg catggcccgg gtggccggtg agctggccga tgccgcgatc acctggctca
    16921 ccccgccgtc ctacctgggc gaggtgctgc tgccggaact gcgcgccgcg gccggggcgg
    16981 ccgggcgggc ggcgccgcgg gtggtgacgg tggtgcaggt cgcggtgcgg cggcccgggc
    17041 gcgatccaca cctggtggcg ctcaacggat cccgcgagca cctggccgcc ccgcactaca
    17101 cggacatgtt gcggcgggcc gggttgcggg tgcacccgtc gcaggtcccg ttgagcgcgc
    17161 gggccctggt gtcctcgggg accttcgtga ccggcacggt ggccgagatc gccgagggcc
    17221 tggaccggta ccgggcggcc ggggcagacg aggtggtgct caacaccgcc ggggtgcacc
    17281 tgaccgaggg ccgggccgcg gccctggaag acctgggcga actactcgcg gccctggctg
    17341 ggtgatcagc gggcgtcggc ggtacgcacg gtcaggatgc ggaccaggcg gtcgccgggg
    17401 tgcgggtccc ggccgtgcca gcagcggtag ttgtccacca ccaggatctc tcctgccgtg
    17461 gggcggaacc tcggcagtcc gggctggatc tgttgcacgg cttcggtgaa ggcggccagc
    17521 atccggtcgg cgtgctcggc gcccggatcg cggtgcaggg gcacggcgcc gtcggtgcgg
    17581 cgcacgatcc ggcggccggt gcgggtgtac tcgacgtgcc gggccaccct gggcagcgcg
    17641 ggcacgccgc ggatggcgcc ccacttgccg tagaggtcca cgtcgacggt ggtgaggaac
    17701 tcgcgcagct ccggctcggc gtgctcgtcg acgaagcagt aggcgtcggc gaggaaggag
    17761 tcaccgccgc tgggtgcggg ctgaacacat tgcacgaaca caaaatcctc gtccgggtcg
    17821 cggcgcgggg tggggatgcc cgcgaggtcc acgaccaggt tgaagctgtc cgcgtgcagg
    17881 tccaccgggc cgccgtcctg gcttgggcgt tcacgcagtg ggaacagccg gcgcaggcgc
    17941 gggccgagca cgctcgcggc cgcgacgacg agtgcgtcgg cggtggcggg caggccggtg
    18001 agcaggaccg cgccgtcggt ggccagagcg gtgcgggctt cggtcacggc gttgacgtcg
    18061 tggcgttgcg gcacaatgcc gagcgtggtc atcgggcgaa cctccgggcg gtgggggcca
    18121 gggcggccag ggcgggggcg gcgaagcaga cgagcgcgca gccggcgagc accgcggtca
    18181 cgccgaaagc ctcgatggcc ggggcgatca gggccaggcc gaccggggcg aggccgtagg
    18241 agaacaggaa gtccactgag gacacccggg cgagcaggcg ggggtcgacc tcgcgctggg
    18301 tcgcggtgaa ccagggcacg ttgaacaact cgattcccac tccggtgacg acgtaggcgg
    18361 cgatcacgac cgcggggtgc acgtcggcga tcaggctcag tggggccagg ccgtacaggg
    18421 ccaatccggc cagcgcggcc cagccctggg agcggggccg ccagcgggcg atgatcagtg
    18481 cgccggccag cgcgcccgcg gtgtacccgg tgagcgccga ggccagcacc agctcggagc
    18541 cgtagcggtc ccggctgatc agcggcagtg cgacgccggt ggccgagtag ccagtcgcga
    18601 tcaccgcggt cagcgcgccc aggccggcca ggaaccaggg gtgcctgcgg gcctcgcgca
    18661 ggccgtcggc gaactcgcgg accaggtggg tgcgctccgt cggcgttccc gccgcgcccc
    18721 ggggtgggag cagggcggcg accagccaca gcagcgcggt gccccagagc agggcggaca
    18781 ggtccagcac ggtggccagc aacgcggtca gccccggtcc gagcagggtg ctgacccgga
    18841 ccgccagggt catcgcggcg ttggcctgct gccgctgatc ggggtcgacg acctccgcgg
    18901 tcagtgcctg gaaggcgggt cggcaggcgc cctggcccgc gccgaccagg gccgcggcgg
    18961 tcgcggtgag cacgagggaa tcgcccaggc cccaggcgat caccggggtg gcggcggccg
    19021 cgagcaggcc ggagaccagc accacgccgc gccgggaatg ccggtcggcg agcacgccgc
    19081 ccaggggcac ggcgatcagg aagccgacgg tccgcgcggc cagcagcacg ccgagtccga
    19141 ccgcggtcag actccggtcg agcacggcca ggccgaggat gaagggcagc gcccaagtgg
    19201 ccagtccgga cgcggtggtg ccggtccaca gccgcaggaa ggcccggtcc cggagcacgg
    19261 tggacaggtt gctctcctcg ccctattgga aatcgttgtc aatgtactac ggtgtctatc
    19321 gcaacttagt tgctgttgca agatcctcgc atcagtccag ctggaggtca gcttgtccca
    19381 ccgcgcccgc ctgggctgcg cactcgccgc cgtggtcgcg gtggcctcgt gcgcagcgcc
    19441 cgccaacgct ccgtccgcag gtcaggccgc ggtcaccgtg tccagttgtg ggcagcagct
    19501 gcgcttcgag cactccccgc agcgggccgt gacgctggag cagtcctcca ccgagacgct
    19561 gctcgcactg gggctgggcg agcggatggc gggcaccgcg taccgggcag ggaggattct
    19621 gcccgagtac caggcggcct acgacaagat cccggtgctc aaccccaagg cgctctccgg
    19681 cgagcagttg cgcgcggccg cgccggacct ggtggtgagt tccttcgcga gcaacttcac
    19741 caaggacaag gcgggcaccc gcgcggagtt gcaggcgctg gggctgccgt cctatgtcag
    19801 cgcggtggac tgcccggagc acgagccggg cctgaccccg ttcgagcggc tgttccgcga
    19861 ctacgagaac tacggcaagg tcttcggcgt ggccgaccgg gccgccgcgc tgaccgccaa
    19921 gcaacgcgag gtggtgcagc aggccggggc ggtgcgcgcg ggccggcccg gcaagccgac
    19981 cgtggtgtac gtgtactcgg tgttcaaggg cctgccctat gtcgcggggc acaacgggat
    20041 gcccagcgac atgagccgga tcctgaacgc gcccaacgct tttgacgaca tcaacgagga
    20101 gtggccggag atgtcgtggg aggagatcgc caaacgcgat cccaccgtga tcgtggtcgg
    20161 cgacctctcc gaccgcggcg cgccgggtga cagcgccgcg gagaagctca agatgatgcg
    20221 cgagcacccg gtggtgtccc agctgaccgc ggtgcggcag aaccggatca tcgaggtgcc
    20281 cggcatcgaa ctcgacccga ccgtgcgcag cgcgaacacg ctgcggctgc tgggcgaggg
    20341 cttgaaggca ctcggtgtct gagccggacc tgctgcaccc cgccgcccgc tcccgcccgg
    20401 aaccgccact cccccggccg cgcggccgat cgggctggtc caccaccgcg gtgctcctgc
    20461 tcgggatcgt ggtgctgatc gtctcgatgg ggctcgcggt ccggatcggc gtcagcggcg
    20521 tgggttttgc cgagatcggg cggaccctcg gcgtccggct cggtctgccg gtgacgccgt
    20581 tgccccggct gctggactcg ctgatctggg agctgcgggt gccgcgggtg ctgctggccg
    20641 cgctggtcgg cgcggcgctg gcggtgtgcg gggccgcgct gcagggcgtg acccgcaacg
    20701 cgctggccga tccgtacctg ctgggcgtgt ccaacggggc ctccgcgggt gcggtcgccg
    20761 tggtcgtgct cggcttcggc gccggtgcgc tcggggtgac cggcggcgcg ctcgcgggcg
    20821 cgctgctgtc cttcgggttg atgctgttgt tgttgcgccg cagcgggatg cacccggtgc
    20881 ggatcgtgct caccggtgtg ctggtcgggc agctgttcgc cgcgatcacc tcgctgatcc
    20941 tgatggcctc cgccgatgcc gacaccacca gggcgatcac ctactggctg ctcgggtcga
    21001 tggcctcggc gcgctgggaa gcggtgctga tctgcgccat cgccggtgtc atcgggatgg
    21061 tggtgatctg gttgtgcgcc accgcgttgg acggcttctc cttcggctcg gacaccgcgg
    21121 cctcactggg ggtgaacgtg cggaccaccc gcctggtgct gctggtggcc accgcgttgc
    21181 tgacctcggt ggcggtggcc tcggtcggcg cgatcggttt cgtcggcctg atcgtgccgc
    21241 acggggtgcg gttcctggtc gggccgacgc accgggtgct gctgccggtg accgcggtgg
    21301 ccggggcggt gttcctggtc tggaccgacg cgctggcccg gatcgccttc gcgccaaggg
    21361 aggtgccggt gggggtgttc accgcgctgg tcggcgtgcc gttgttcctg ctggtgctgc
    21421 gcaggcgggg tgagctgtga ggatcggcgt gcactcggtg tcctggtcgg tgccgggcaa
    21481 gaccattgtg gacaacgtgg acttcaccgt ccactccgga cagaccgtgg gcctcatcgg
    21541 cccgaatggc tcagggaagt cctcgctgct gcgctgtgtc gccgggctgc gcaagcccac
    21601 cgcgggtgtg atccgctttg acggcaagga catcggcggc tggacaccgc gcaagatcgc
    21661 ccagcagctg gctttcgtgg aacaggccgg ggacaccgac agcgatctgc gggtggccga
    21721 ggtggtcgcc ctgggccgca ccccgttccg gccgggctgg cgggcgccgg gcgcgcacga
    21781 tcacgccgtc gtcgaggccg ccctggaccg gctggatctc atcgagctgc gcgaccggca
    21841 ctggcagacc ctctccggcg gtgaacggca gcgcgcgcac atcgcccgcg cgctggccca
    21901 gcagccgtgg gcgatcctgc tcgacgagcc gaccaaccac ctggacatcc ggcaccagct
    21961 ggaactcctg gacctcctcg cgcgcaccga acagaccgtg ctggtcgccc tgcacgacct
    22021 gtcccttgcg gcccgcttct gcgaccagct cgtgctgctg caccagggca agctggtcgc
    22081 ggccggtgcg ccgcaagagg tgctgaccgc acggctgctg cgcgaggtct tcgaggtgga
    22141 cgccgaggtc gggcaggaca gcgcgggcaa cctcgcggtg gtctatcgcg ggactgccga
    22201 ccgggtcagt cctgcttgcg tggaaccaac aggccgcggt ggaacgcctc ggtgatggcg
    22261 gcggcacggt cgttcacccc gagcttggcg tagatgttga gcaggtggga tttgacggtg
    22321 gcctcggtga ggaacaactc ggccgccgcc gcccgattgg tggccccgcc cgccaccagt
    22381 tccaggacct ctacctcacg cgggctcagc ggtccgggcg cgggtttgcg cacccggttc
    22441 atcagcagcg cggccaccga gggcgcgagc accggctcgc ccctggccgc ggcccgcacc
    22501 gcgcgcagca gctcgtcccg gggcgcgtcc ttgagcaggt agccggtggc gccggcctcg
    22561 atcgccggga gcacgtagct gtcggtgtcg taggtggtga gcaccagcac ccggcactcc
    22621 ggcgcctgcc cggccagttc ccggatcgcg ctgaccccgt ccaggccggg catccgcagg
    22681 tccatcagga tcacgtccgg gcgcagccgc cgggccagcc ggaccgcctc ggccccgtcc
    22741 gcggcctcgc cgagcaccgc gaactccggg tcgcgggcga acatgccggt cagcccgtcc
    22801 cggaccaccg ggtgatcgtc gacgaccagc agtccgatcg gcttgttcac gcgcacacct
    22861 ccgccagttc caagggcacc cgggccgaga tcccggtgcc caggcccggt tcggattcca
    22921 cctgcagggt gccggacagc tcggtcaccc gctgccgcat cgcgatcagg ccgaagccgc
    22981 cgcgatcggg tcgcgggtcc tcgatgcggg ccgggtcaaa accgtcgccg tcgtcccgga
    23041 tgtccagggc ggcttcctgt tccaggtagg acagggtcag gccgacccgg cccgctcgcg
    23101 cgtgctgggc cacgttggcc agggcttcct gcgcgatccg gagcagcgcg gcctccgcct
    23161 cgggccggat cggccgcgcc gcgccggtgg tggtgacccg gaccgggatc tcgtgcagtg
    23221 cggaccagcg ctgcgcgacc ccggccagtg cctcgctcag cctggccacg cgcagtggtt
    23281 cggggcgcag cgcgtgcact gagcggcggg cctcggtcag gctctcccga gcgagtttgt
    23341 ccgccgcggc aacgtgtttg cggcaggctg ccgggtccgt ggtgtcggcc gcgcggagct
    23401 ggctgatgat gccggtcagc ccctgggcca gggtgtcgtg gatctccctg gccatccgct
    23461 gccgttcctc ccggaccccg gcgtcgcggg cctgagtgag cagctgctcg tgcagggccg
    23521 cgttctccgc cagcgaggcc gcgagtcgac ggttggcctc gcgggcctcg cccagggcgt
    23581 gctcccgctc ctcctccttg cgggcggccc gccgggcgaa cgcggcgtaa ccgcacatgg
    23641 gcagcacgtt ggcggccagc acggcgaggt agatgagcac gccgaacgcg gtgctcttgt
    23701 ccacgccgga agcctgcgcg gtgcccgcgg ccaccgccac cccagccacg ccggccagtt
    23761 gccacggcca gcgcagcagc cgcagcgcgt agaggtagcc gacgggactg aggaacccga
    23821 accagggcga gctgaccacc aggaacagcg agcacagcac caccccggcc acgaacaccg
    23881 ccatcctcgg cgcgttcgtg cgccaggccg ggcgcagggt gaacatgccc agcatccagg
    23941 ccgccagcag ggcgcacacg aggaggtccg ggaccgggga ttcgccgatc ttgtgcttga
    24001 tcggcaccgt gatcacggcg aggaaggcca gcaacgcgta cggtccggcg gaggtcacca
    24061 gggaccaccg cggcactggc tcgctcatcc gcgttctcct cccccggcca ctgtggacaa
    24121 tctagccagc ttcgaccgac agcgagtgcc ggaagacgtt acgtgggtcc cacttggcct
    24181 tgatccggcg tagccgcggg tagttgtcct tgtagtacag cgtctgcgcg gacacgcccg
    24241 aggtgttcca gaccgggtcg gccaggtcgg cgtcggcgta gttgatgtag gagccgtcgt
    24301 tgaccgggcc gggcacgggc acgccgccgg tctcgatgta gacgtcccgg tagaactcgc
    24361 gcacccactt gaggttggcc ttgtcctcgg tgtcgtcgcg ccagatcgtc tggtagaccg
    24421 ccttcatgat cacgtcccgc tgggcgattg cggtggcccc cggcgcgacc gcgttggcct
    24481 ggccgccgta gctgatcagc agcatgccgg cgtgcgggcc gccgctgtcg ttgatcaggt
    24541 ggcggtggat ggtgg
//
