LOCUS       NZ_JALMDK010000001     22109 bp    DNA     linear   CON 13-SEP-2024
DEFINITION  Crossiella sp. S99.2 NODE_1_length_1315984_cov_209.361043, whole
            genome shotgun sequence.
ACCESSION   NZ_JALMDK010000001
VERSION     NZ_JALMDK010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Crossiella sp. S99.2
  ORGANISM  Crossiella sp. S99.2
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Crossiella.
REFERENCE   1  (bases 1 to 1315984)
  AUTHORS   Gonzalez-Pimentel,J.L.
  TITLE     From North to South: A Spanish map of bacteria producing bioactive
            compounds in show caves
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1315984)
  AUTHORS   Gonzalez-Pimentel,J.L.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-APR-2022) Agroquimica, Microbiologia Ambiental y
            Conservacion de Suelos, Instituto de Recursos Naturales y
            Agrobiologia, Av. Reina Mercedes 10, Sevilla 41012, Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2021
            Assembly Method                   :: SPAdes v. 3.14.1
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 200x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023094165.1-RS_2024_09_13
            Annotation Date                   :: 09/13/2024 06:26:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,481
            CDSs (total)                      :: 9,422
            Genes (coding)                    :: 9,365
            CDSs (with protein)               :: 9,365
            Genes (RNA)                       :: 59
            rRNAs                             :: 2, 1 (5S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 1 (5S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 8 of 57
            Pseudo Genes (incomplete)         :: 50 of 57
            Pseudo Genes (internal stop)      :: 4 of 57
            Pseudo Genes (multiple problems)  :: 4 of 57
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:32:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 869301
            Orig. end                         :: 891410
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JALMDK010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22109
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="3"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22109
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22109
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12109](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12109)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            74..793
                     /locus_tag="MZC64_RS04255"
                     /old_locus_tag="MZC64_04255"
     CDS             74..793
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670229.1"
                     /locus_tag="MZC64_RS04255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04255"
                     /product="response regulator transcription factor"
                     /protein_id="WP_247755729.1"
                     /transl_table=11
                     /translation="MEQKPGQAQVRGRVLVVDDDLTVRDVVRRYLEGAGHQVRVAGDGE
                     QALALFEQAAADLVVLDLMLPGIDGLEVCRRLRRHSAVPVVMLTALGEEEDRVAGLQLG
                     ADDYVTKPFSPRELVLRVNSVLRRLRVPAPPPRLDHLADGDLRLDPVARRASRSGAELA
                     LTTREFDLLAFLIAHPGEVYTRAKLLELVWGWDFGDAATVTVHVRRLREKIESDPANPV
                     RIATVWGVGYRYDPSPA"
     gene            790..1800
                     /locus_tag="MZC64_RS04260"
                     /old_locus_tag="MZC64_04260"
     CDS             790..1800
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009946232.1"
                     /locus_tag="MZC64_RS04260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04260"
                     /product="sensor histidine kinase KdpD"
                     /protein_id="WP_247755730.1"
                     /transl_table=11
                     /translation="MSELAHAATYALSFSVPVALLGALFLHWCRDRSLTAAITVAVLTP
                     LLATLAGVTAVSGFMFTSQLTTTVVICVLVGLVTVPAAMLFGRAIARRSVWEREARARE
                     RAAEAARRELVAWISHDLRTPLAGMRAMTEALTDGVVTEPAEVRGYLLGIGRETERVSA
                     MVDDLFQLSRITAGALNLELTALPLRDLVSEEVAAQAAIAQRAGVTLAEVPSEWPVVHG
                     SARELSRVLRNLLSNAIRHTDRGGVVAVAAGEVDGQGWLAVDDGCGGIPDGELPRVFDV
                     AYRGSAARTPEPEQAAGAGLGLAIARGLVEAHHGRISASNHGPGCRFEILLPLAR"
     gene            1845..2681
                     /locus_tag="MZC64_RS04265"
                     /old_locus_tag="MZC64_04265"
     CDS             1845..2681
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021509.5"
                     /locus_tag="MZC64_RS04265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04265"
                     /product="oxygenase MpaB family protein"
                     /protein_id="WP_247755731.1"
                     /transl_table=11
                     /translation="MGAEETGLFGPDSVTWRVHSDPVLFLGGLRALFLQALHPLAMAGV
                     AQHSQFQADPWGRLIRTAEYVGTVTYGSLSQAQAIGAVVRRAHRGLTGVEPETGQAYRV
                     TDPELLLWVHNCEVDSFLDTARRSGMRLRAAEADAYLAEQVRAARLVGVPEAMVPDSVD
                     ALADYFARMRPVIRCTAAARRTARFLLFPPMPTPVQLFTPARPAWAALAALSYSLLPDW
                     ARRGYGLTGLPGTELTATALARSLRLVLLALPTSLRQGPHYRAAQARIASVCDRTA"
     gene            2721..3323
                     /locus_tag="MZC64_RS04270"
                     /old_locus_tag="MZC64_04270"
     CDS             2721..3323
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MZC64_RS04270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MZC64_04270"
                     /product="hypothetical protein"
                     /protein_id="WP_247755732.1"
                     /transl_table=11
                     /translation="MSAPESKPTRAQGPDLVEQGPEDAEVLFVLDPAGLGRHGHLPASW
                     RGIARSTHIAWLRLPAAEAAMPRARDVLERLAEGGGPIDLVAEGAAAEPAMLLATESFA
                     GGEARQVRSVLLVDPEPRSRPIEQMLIGHGVRVKVLDRGVAPVPLGHPRVAAEVAGELH
                     GRRMPPRARGGTRRPSVAGQVWQAVRMRIRDRLTRSR"
     gene            complement(3344..4030)
                     /locus_tag="MZC64_RS04275"
                     /old_locus_tag="MZC64_04275"
     CDS             complement(3344..4030)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007026510.1"
                     /locus_tag="MZC64_RS04275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04275"
                     /product="response regulator"
                     /protein_id="WP_374205615.1"
                     /transl_table=11
                     /translation="MVSEQSVEPIRVVIADDQELVRAGFRLILDSQPDIEVVAEAEDGA
                     NAVFATRMLRPDVVLLDIRMPTMDGIEAARVICAETEAKVVMLTTYDLDEYLYDALHAG
                     VSGFLLKDVRRDDLVHAVRVVVTGEAMLAPSMTRRLVQDVVSRALRPTPDNPDPRLDTL
                     TAREAQTLELVARGLSNAEIAKAMVLSEHTVKTHVSSLLTKLDLRDRVQAVVFAYEYGV
                     VGSGRV"
     gene            complement(4033..5232)
                     /locus_tag="MZC64_RS04280"
                     /old_locus_tag="MZC64_04280"
     CDS             complement(4033..5232)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019350.5"
                     /locus_tag="MZC64_RS04280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04280"
                     /product="sensor histidine kinase"
                     /protein_id="WP_247755733.1"
                     /transl_table=11
                     /translation="MSTPLGWRPPRPLQNLSARQADLLVVVIVLLAVELPLGFGLGGGP
                     PPWWGYLVAASTALPLLFRRQAPMLTMIAVSVAELVYIALDLPDIWSIYGPLVGVYTVS
                     RNSEPLIRRITLALALLAVVVHSGLDQMDFQEFTFLTTCSVTAYLVGWAVRTNAAYTVA
                     LEERAHRLEQEQQLEAERATSAERARIARDMHDILSHAVALIVVQAESGPLVVRADPAR
                     AEASFDAIATAGRDAMAQLRRLLGMVPRDPAELRRAPQPTMDDVPRMIETVRATGLHVE
                     HSVSGAPAPLPPDTELAVYRLIQEALTNTVRHARAGRAEVRLSWSRAELAVLVLDDGIG
                     ADSPAPGRGGRGLVGIRERVGACGGVVRIGPREGGGFMVTAEIPLAHKDFPVSRVERGS
                     "
     gene            complement(5300..5671)
                     /locus_tag="MZC64_RS04285"
                     /old_locus_tag="MZC64_04285"
     CDS             complement(5300..5671)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MZC64_RS04285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MZC64_04285"
                     /product="hypothetical protein"
                     /protein_id="WP_247755734.1"
                     /transl_table=11
                     /translation="MSAPLAPDSGAYSVEQYRALLAGTPLPRLEEVHAAVWPRLSPQVR
                     RTVLVCFAQRSGEEELGGGGELGTVAAGAAGGFAGEQATDYLFADPDPGDAVATRPPGP
                     EPPEPPGPTEPAEQQPERP"
     gene            complement(5903..6649)
                     /locus_tag="MZC64_RS04290"
                     /old_locus_tag="MZC64_04290"
     CDS             complement(5903..6649)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014691.5"
                     /locus_tag="MZC64_RS04290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04290"
                     /product="Fic family protein"
                     /protein_id="WP_247755735.1"
                     /transl_table=11
                     /translation="MYRQALEPDSWHDGRLLTISEVRRIHHTAMTPVWDVAPHKDATDR
                     EGPGCFREHDIQPFSGGMTPPAWPLVPVLMQQWVDAVCLAGRGIGANGQADLPLTEELA
                     RLHNEFERVHPFLDGNGRTGRLVLNLVLVRLGYPPVVIFKRQRDAYLTALQRADSGDYG
                     ALGELIARAMYDNLNRFIVPNMAGPARLVPLAALVTEDFTLAALRQAARRGRLDAVQGP
                     DGVWRSSRKAVAAYQDNKHKRRRSAG"
     misc_feature    6748..6761
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
     gene            complement(7014..7973)
                     /locus_tag="MZC64_RS04295"
                     /old_locus_tag="MZC64_04295"
     CDS             complement(7014..7973)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011872924.1"
                     /locus_tag="MZC64_RS04295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04295"
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_247755736.1"
                     /transl_table=11
                     /translation="MRWSRLVMSVLALTLGLAGPAEAAPAEVRVLTWNIWRGGLGAGAD
                     NLPRLLDQIVAVRPDVLLAVETYGAGEQIRQALTRRAGKGAYSGTQITPSTTGGDNLWI
                     FTRYPVTKTYPAPSGGKVTAFNFGGVQVRLPGGRPLNLFDTWLPYTDPWSGYLIDENAA
                     AIRAGLPPRHTPAAVAAAETAQTGYLSEIIARHLPAGPAVLGGDFNTPAASDWTEKWKD
                     CPNHFGMAYPLRTTDLLVEAGFTDTFRAAHPSPCTAEGRTWSPQPTERMITPQRIDLTF
                     ARGAVVTGSQVLDTRLPRHGPGVFYSDHAALLTSLRVN"
     gene            8140..9111
                     /locus_tag="MZC64_RS04300"
                     /old_locus_tag="MZC64_04300"
     CDS             8140..9111
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013229597.1"
                     /locus_tag="MZC64_RS04300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04300"
                     /product="DUF5937 family protein"
                     /protein_id="WP_247755737.1"
                     /transl_table=11
                     /translation="MILLRCDATTVANIRLSHSPIMEAVTWLGLAAGGGRHPVFGDPGA
                     LARDALGAAEVELVTDLLPLDGNHYTPDLLTPQPRPGSSGEALEAQLTDLAETSAELVA
                     QQLGFAEKHWRRPVSPRVRRLAETGRLAGRLAAGLGTFWRRALAEGWGEIEALADADLA
                     DRARLLATRGVGELLATLDPRCSWTGAAVAIDKPFQVEVNVSGQPIVLVPSVLSWPKFM
                     IQCDDQQQVALYYPAARVGVRARRDPAELARVVGATRAALLADLGAPRSTAELALRHKL
                     AAGTVSYHLGALRRANLVTASRDGRFVLYQRSAQAEVLLAAS"
     misc_feature    8164..8179
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.79"
                     /tool="antismash"
     gene            complement(9108..10004)
                     /gene="pqqB"
                     /locus_tag="MZC64_RS04305"
                     /old_locus_tag="MZC64_04305"
     CDS             complement(9108..10004)
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631257.1"
                     /locus_tag="MZC64_RS04305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04305"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_247755738.1"
                     /transl_table=11
                     /translation="MKVLLLGTAAGGGFPQWNCACRMCSAGRDGLLTHRTQDGIAVSAT
                     GERWFLVNASPDIRAQLLAHQEFRPKPPRDTPVKGVLLTDAELDHSLGLMLLREGDNLQ
                     VWAPEAVLHGLTEDFGLRGTVEHYRRWDWHTVSPGVPVHPAGELTVTAFPVSGKRPRYA
                     AASTMDGPWVVAYRITDPATGGTLVYAPCLREWPAGFDEFVADADCVIIDGTFHSAAEM
                     SGATGKKADADQKSMGHIPIAGPGGGLDVLSRFPGKHRILTHLNNTNPVLDPASAEHAE
                     VLTAGVSAPPDGTLFEL"
     gene            complement(10001..11125)
                     /gene="pqqE"
                     /locus_tag="MZC64_RS04310"
                     /old_locus_tag="MZC64_04310"
     CDS             complement(10001..11125)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983456.1"
                     /locus_tag="MZC64_RS04310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04310"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_247755739.1"
                     /sec_met_domain="PF04055 (E-value: 4.4e-19, bitscore: 65.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.1e-06, bitscore: 24.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 4.9e-11, bitscore:
                     39.1, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.6e-11, bitscore: 39.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEIPVSPAEAPLGMLAELTHRCPLHCPYCSNPLELIAKNNELTT
                     DQWRSVLTQARELGVLQVHMSGGEPLARHDIRELVEHASDLGCYVNLVTSGLGLTEPVL
                     QDLADRGLAHVQLSIQDSDPVRGNQVAGARAHDRKLAAAQVVHKVGLPLTGNVVLTRLN
                     HDRIGEIITMAESMGVDRLELANTQYYGWALKNRAKLMPTREQLATAEPIVRAASKRLA
                     GRMQVVYVVADYYEDYPKPCMHGWGARQLTVAPNGDVLPCPAATAISTLKLDNVKDRPL
                     AEIWYQGESFNAYRGTEWMSPTCQVCPRKETDFGGCRCQAFLLTGDAAATDPVCSKSPD
                     RPLIDTILARHHQAPEPLDAPLAMRWPAAERGAR"
     gene            complement(11118..11402)
                     /gene="pqqD"
                     /locus_tag="MZC64_RS04315"
                     /old_locus_tag="MZC64_04315"
     CDS             complement(11118..11402)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009079179.1"
                     /locus_tag="MZC64_RS04315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04315"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_247755740.1"
                     /sec_met_domain="PqqD_RRE (E-value: 1.1e-23, bitscore:
                     79.1, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.9e-11, bitscore: 40.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEITGTSRPRLRRGVRLSYDKVRETHVLLFPEGVLVPNPTAAAV
                     LEHCDGVNDVDAVVKLLSERYQGVSVADVAGLLAALIERRIVELAVADV"
     aSDomain        complement(11136..11399)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_MZC64_RS04315_PqqD_RRE.1"
                     /evalue="2.40E-25"
                     /identifier="RREFam006.1"
                     /label="MZC64_RS04315"
                     /locus_tag="MZC64_RS04315"
                     /protein_end="89"
                     /protein_start="1"
                     /score="79.1"
                     /tool="antismash"
                     /translation="SEITGTSRPRLRRGVRLSYDKVRETHVLLFPEGVLVPNPTAAAVL
                     EHCDGVNDVDAVVKLLSERYQGVSVADVAGLLAALIERRIVEL"
     gene            complement(11408..12109)
                     /gene="pqqC"
                     /locus_tag="MZC64_RS04320"
                     /old_locus_tag="MZC64_04320"
     CDS             complement(11408..12109)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019813814.1"
                     /locus_tag="MZC64_RS04320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04320"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_247755741.1"
                     /sec_met_domain="TIGR02111 (E-value: 3.5e-79, bitscore:
                     261.7, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATSQDVLSREDFLAALQALSHRYWGTHPFHQRMHAGELTEHELR
                     TWAANRWYYQCMLPQKDAAIISNCPLPEVRRLWLDRIVYHDGKAEGEGGAESWLRLCQA
                     VGLSREEVLDQRHIAPGTRFAVDAYVNFARQQPWIIGVASGLTEMFSGHLMRQRVSDVL
                     AGYSWIRREDLAYFTTRIDKVSGEGKETVDLVLEHCDSRELQDAAVAALSFKCDVLWSL
                     LDSIERAATKG"
     gene            complement(12207..12296)
                     /gene="pqqA"
                     /locus_tag="MZC64_RS04325"
                     /old_locus_tag="MZC64_04325"
     CDS             complement(12207..12296)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033797.1"
                     /locus_tag="MZC64_RS04325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04325"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_185000163.1"
                     /transl_table=11
                     /translation="METREVWTRPEFTEYDTPMEVTAYAARMD"
     misc_feature    12411..12425
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.49"
                     /tool="antismash"
     misc_feature    complement(12487..12500)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.66"
                     /tool="antismash"
     misc_feature    12488..12499
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.37"
                     /tool="antismash"
     gene            12570..13562
                     /locus_tag="MZC64_RS04330"
                     /old_locus_tag="MZC64_04330"
     CDS             12570..13562
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670614.1"
                     /locus_tag="MZC64_RS04330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04330"
                     /product="sorbosone dehydrogenase family protein"
                     /protein_id="WP_247755742.1"
                     /transl_table=11
                     /translation="MHARRRTVIGALVATATAAAAFTAPVATASEVSPMAIKQIASGLN
                     QAWAVDWLPDGTALFTEKDSKKIRKIDKAGKVSDVQTIPGVSVTKEAGLLGIAVSPTYA
                     ADQLVFIYYTTGSDNRIAKLKLGQAPQPIVTGIPRGSQFHHGGRIAFGPDGFLYAGTGD
                     GQNGANAQNKNSLGGKILRITKDGAAAPGNPFNSRVYSFGHRNVQGLTWVGGQLYASEI
                     GASKVDELNKIDSGKNYGWPNCEGSCGTGGMTNPVKTWPTSQATPSGLAHYKGSLYIAS
                     LKGGTYKTNTSGSGGKIYTNLGRTRAANAAPDGSLWIITPGGIYTSDGN"
     gene            13650..14651
                     /locus_tag="MZC64_RS04335"
                     /old_locus_tag="MZC64_04335"
     CDS             13650..14651
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098210.1"
                     /locus_tag="MZC64_RS04335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04335"
                     /product="sorbosone dehydrogenase family protein"
                     /protein_id="WP_247755743.1"
                     /transl_table=11
                     /translation="MPVARLAALAAAVTLGLLAATPAQAATRPPTEVTGGLAVPWGVGF
                     LPDGSALVTERDTARILTIRGGKATEVQKIADAQPTGGHGGLLGLAISPHYQRDRTVFV
                     YYSTKTDNRIAKLRLGQPPAPLVTGIPLGVKRNGGRLAFGPDGHLYATTGDTARPELAQ
                     DPKSLAGKVLRLTTTGKPVLGNPFGTLVYSYGHRDPQGLTWDRDGRLFLAEAGDTQWDE
                     LNRVLPGRNYGWPLCEGKCGDPRFIDPLVVWRTEEATPSDLAYYKGSLYVAGLVGQRLW
                     QVPLRDGRTGTPKALYHKEFGRLRTVEPAPDGSLWITTSNAPAPDRILRSEG"
     gene            complement(14648..15532)
                     /locus_tag="MZC64_RS04340"
                     /old_locus_tag="MZC64_04340"
     CDS             complement(14648..15532)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025465.5"
                     /locus_tag="MZC64_RS04340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04340"
                     /product="PmoA family protein"
                     /protein_id="WP_247755744.1"
                     /transl_table=11
                     /translation="MTALTMRHVPDRSVDLFHSGVRLLSYHYRPDDPPRESPKPYFHPL
                     RTLRGALVSDYRPADHTWHKGLQLAVAHVDDTNFWGGPTYRAGAGYVDLPNNGSQLHLG
                     FDQVASTGTTFELRQRLSWRTATGAELLAERRHVQVTVSAPDQAWQLTFDTWLRNTTAA
                     SIRFGSPSTNGRPDAGYGGLFWRGPREFLGGRVLVPGARNPMGARASWAAYIGRQDETG
                     THSTVLFVDSPENPGHPTQWFARSSDYPGLCPAPFYSAEVRLPPGEQLALRYTVVFADG
                     AWDESRITDFLGR"
     gene            complement(15600..16349)
                     /locus_tag="MZC64_RS04345"
                     /old_locus_tag="MZC64_04345"
     CDS             complement(15600..16349)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005466194.1"
                     /locus_tag="MZC64_RS04345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04345"
                     /product="class F sortase"
                     /protein_id="WP_247755745.1"
                     /transl_table=11
                     /translation="MGRSLYPGETKRDNRARMAGLGLLGVAAVCVAAGLGASQLSTTVV
                     GEPVAVESPPPSPLRARPLTDIGDAPLIRWGQPGGGNPAQTTTPAKPGQPNQIVQPAGG
                     QRPGTVRLPEGGTATLVRREVAPDGVLPVPDGIRDATWWGAGLDSAKGATVLAGHVNWK
                     GSTGPFAELWRSDKGQQVTVKDATGKTYTYRITEVHTVHKDQLPQRAESLFAQSGNHRL
                     VLVTCGGQWIGGRLGYDDNRIIIAERG"
     gene            complement(16353..17777)
                     /locus_tag="MZC64_RS04350"
                     /old_locus_tag="MZC64_04350"
     CDS             complement(16353..17777)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011873204.1"
                     /locus_tag="MZC64_RS04350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04350"
                     /product="hypothetical protein"
                     /protein_id="WP_247755746.1"
                     /transl_table=11
                     /translation="MPGLRNLLVGAMSVTLAAGGLALAIPGSALAAGERSGEYTKPQEY
                     QGRPKGDDWIGSYTWRGRQVWCVRYALDEPGDALEYTPSKDGLTTKWNTPIPAETKAKI
                     SYLLLRYQDTASKPEAAALAHLLHSWTSGTKDPKLLAKTNNFTRIGYDVDFHLNGLSAE
                     ARQAVGRLQADADAHYGPWKLTVAAPKDGQLIGKPGNWTITVTSAKGQPVSGVPVKLKA
                     IDAELAGEASDGAVKTPAGGKPLVIAVTPKGPNPKLVATVESPNADPVLLLPNKPTAQR
                     ALTTGGQTPISAEATVPAVTQPGIVKIGKVDAASGAAIPGVTLRITGPDKEAPALKQDG
                     SPLTGVDGKPLVVKTGDDGQVSVADLRTPQEICLIELIPAKGYEEGFDPKKPPTVCGTV
                     APGNTLALSLTNKANVPKKPVVPRVIPAGDQPDLPVAQAATVTQVEPAGLVGFAIFTLV
                     MATLGVMALRRRLHQR"
     misc_feature    complement(17868..17883)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
     misc_feature    complement(17892..17907)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.67"
                     /tool="antismash"
     gene            18101..18907
                     /locus_tag="MZC64_RS04355"
                     /old_locus_tag="MZC64_04355"
     CDS             18101..18907
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009944151.1"
                     /locus_tag="MZC64_RS04355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04355"
                     /product="Bax inhibitor-1/YccA family protein"
                     /protein_id="WP_247755747.1"
                     /transl_table=11
                     /translation="MRTSSNPAFRNLPHQGSGYATFNTGGQPAGYQAGYQQQPGYQQYD
                     SRPGISERPMTVDDVVMKTATSFGVTLVAGFLTAFFQAYYLALPAVLIGLGVGLFLSFR
                     PRPSAPLTLTYALSQGVALGAISALVNLRFPGIVVQALIGTAGVFAGMLVVYKTGAIRV
                     TPKLTRWVIGALVGVLVLVLANLVASFIVPGGLGLRSGGAIAIIFSIIVIGVAAFALLL
                     DFDQADEMIRSGMDAKWAWYAAFGLTATVVMLYLEILRLLSYFRQD"
     gene            complement(18986..20206)
                     /locus_tag="MZC64_RS04360"
                     /old_locus_tag="MZC64_04360"
     CDS             complement(18986..20206)
                     /EC_number="2.3.1.9"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124: acetyl-CoA acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005466189.1"
                     /locus_tag="MZC64_RS04360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04360"
                     /product="acetyl-CoA C-acetyltransferase"
                     /protein_id="WP_247755748.1"
                     /transl_table=11
                     /translation="MPEAVIVATARSPIGRANKGSLKDVRADDLTAKMVKAALAKVPEL
                     DPREIDDLMLGCGLPGGEQGFNMARAVAVLAGYDHLPGTTVTRYCASSLQTTRMALHAI
                     KAGEGDVFISAGVEIVSSYARGNSDGWPDTQNPLFAQAQARTQHAAEHGASEWVDPRES
                     GLLPDVYIPMGQTAENLALAKGVTREDMDHFGVRSQNLAEKAIANGFWAREITPVELAD
                     GTVVSTDDGPRAGTSYEKVSTLQPVFRPDGRITAGNCCPLNDGAAALVIMSDTKAKQLG
                     ITPLARVISTGVSALSPEIMGLGPVQASQQALKRAGLTVDDVDLVEINEAFAAQVIPSY
                     RDLGIPLEKVNVNGGAIAVGHPFGMTGARITTTLLNSLSWHDKTIGLETMCVGGGQGMA
                     MVLERLS"
     gene            complement(20240..21193)
                     /locus_tag="MZC64_RS04365"
                     /old_locus_tag="MZC64_04365"
     CDS             complement(20240..21193)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016697960.1"
                     /locus_tag="MZC64_RS04365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MZC64_04365"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_247755749.1"
                     /transl_table=11
                     /translation="MFGLRILRAAVFTAGAVGGLSGAAYGLLTEQSKRARKIIGVPAAP
                     LRADGVYLPDGSGPLAPTDPRITGDPLVFAVLGDSSAAGVGCDTTEELPGVLLARGLAE
                     ESEHPVRLLTHAISGATSRELAGQTEAALRTPPDVALVIIGGNDVTARLGPAACALMLG
                     AAVRGLTETGAAVVVGTCPDLGAIRPIAQPLRALVRSWSLTLARAQRRAVQAAGGRPVA
                     LADLLSPEFLTRPSELFSKDMFHPSAAGYAAAVGVLLPELCVAARVWDGGPLPAQPTRS
                     AAAEARRPTAKLVAGLNRRLKRVPPATSHSAAVTGQ"
     misc_feature    complement(21338..21355)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            complement(21377..21805)
                     /locus_tag="MZC64_RS04370"
                     /old_locus_tag="MZC64_04370"
     CDS             complement(21377..21805)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MZC64_RS04370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MZC64_04370"
                     /product="hypothetical protein"
                     /protein_id="WP_247755750.1"
                     /transl_table=11
                     /translation="MKLTVHLFTTDALSFGDALTLPGRGTPDIVCLLPRTELDFSCALA
                     VRAQDGEPGPEELAEHFTLAGTGGADSALLAEVDGRLFALTFGRGAELLEPALLEPEFE
                     GKAIPFPLAGLGHQLSALLGHYDDPLHRAEVPFSAERA"
     misc_feature    complement(21831..21845)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.41"
                     /tool="antismash"
ORIGIN
        1 gcccggtcat ccgaaagaga accgtcatgg ttgtcgccag accggtgcgc acccgccgtc
       61 ctaggctgat ccggtggaac agaagccggg acaggcgcag gtgcgcggac gggtgctggt
      121 cgtggacgac gacctcaccg tgcgcgacgt ggtccgccgc tacctggagg gcgccgggca
      181 ccaggtccgg gtggccggtg acggcgagca ggcgctggcc ctgttcgagc aggccgcggc
      241 cgacctggtg gtgctcgacc tgatgctgcc cggcatcgac ggcctggagg tctgccgcag
      301 gctgcgccgc cacagcgcgg tcccggtggt catgctcacc gcgctcggcg aggaggagga
      361 ccgggtggcc gggctgcagc tcggcgcgga cgactacgtg accaaaccgt tcagcccgcg
      421 cgagctggtg ctgcgggtca actcggtgct gcggcggctg cgggtgcccg cgccgccacc
      481 ccggctggac cacctcgccg acggcgacct gcggctggac ccggtggccc gccgcgcaag
      541 tcggagcggc gccgagctgg cgctgaccac ccgcgagttc gatctgctcg ccttcctgat
      601 cgcccatccc ggcgaggtct acaccagggc gaaactgctg gaactggtgt ggggctggga
      661 cttcggcgac gcggccacgg tcaccgtgca cgtgcgcagg ctgcgggaga agatcgaatc
      721 cgacccggcc aacccggtgc gcatcgccac cgtctggggc gtcggctacc gctacgaccc
      781 gagcccggca tgagcgaact cgcgcacgcg gccacctacg cgctgagctt ctccgtcccg
      841 gtcgcgctgc tcggcgcgct gttcctgcac tggtgccggg accgctcgct caccgcggcc
      901 atcaccgtcg cggtgctaac cccgctgctg gccaccctgg ccggggtgac cgcggtcagc
      961 gggttcatgt tcaccagcca gctcaccacc accgtggtga tctgcgtgct ggtcggcctg
     1021 gtcaccgtgc ccgccgcgat gctcttcggc cgggccatcg cccggcgcag cgtgtgggaa
     1081 cgcgaggcca gggccaggga acgcgcggcc gaggcggccc ggcgcgaact ggtcgcctgg
     1141 atcagccacg acctgcgcac cccactggcg ggcatgcgcg cgatgaccga ggcgctcacc
     1201 gacggcgtgg tcaccgaacc cgccgaggtg cgcggctacc tgctgggcat cggccgggag
     1261 accgaacggg tctccgccat ggtcgacgat ctcttccagc tctcccggat caccgccggc
     1321 gcgctcaacc tggaactgac cgcgctgccc ctgcgtgatc tggtcagcga ggaggtcgcc
     1381 gcgcaggccg ccatcgcgca gcgggccggg gtcaccctgg ccgaggtgcc cagtgagtgg
     1441 ccggtggtgc acggcagcgc gcgcgagctg agccgggtgc tgcgcaacct gctcagcaac
     1501 gccatccggc acaccgatcg cggcggcgtg gtcgcggtgg ccgcgggcga ggtggacggg
     1561 cagggctggc tggccgtgga cgacggctgc ggcggcatcc ccgacggcga actgccccgg
     1621 gtcttcgacg tggcctaccg gggcagcgcg gcacggactc cagagcccga gcaggccgcc
     1681 ggcgccggtc tgggccttgc catagcgagg gggctggttg aggcccacca cggccggatc
     1741 agcgccagca atcacggtcc gggatgccgg ttcgagatcc tgctgccact ggcccgctga
     1801 aagtttcact cgaaagtgtc cttgcgatgc gacactgagt ggcaatgggc gcggaagaga
     1861 caggactttt cgggccggac tcggtcacct ggcgggtgca ctcggatccg gtgctgttcc
     1921 tcggcggcct gcgggcgctg ttcctgcagg cgctgcaccc gctggcgatg gccggggtgg
     1981 cgcagcactc ccagttccag gccgacccgt ggggcaggct gatccgcacc gccgagtacg
     2041 tcggcaccgt cacctacggc tcgctcagcc aggcccaggc catcggcgcg gtggtccggc
     2101 gagcgcaccg cgggctcacc ggagtggagc cggagaccgg ccaggcatac cgggtcaccg
     2161 atccggaact gctgctgtgg gtgcacaact gcgaggtcga ctccttcctg gacaccgccc
     2221 ggcgcagcgg catgcggctg cgcgccgccg aggccgacgc ctacctggcc gaacaggtcc
     2281 gcgcggcccg gctggtcggc gtgcccgagg cgatggtgcc ggactcggtc gacgcgctgg
     2341 ccgactactt cgcccggatg cgcccggtga tccggtgcac cgcggcggcc cggcgcaccg
     2401 cccggttcct gctgttcccg ccgatgccga cgccggtgca gctgttcacc ccggcccgcc
     2461 cggcctgggc cgcgctggcc gcgctgagct actcgctgct gccggactgg gcccgccgcg
     2521 gctacggcct gaccgggctg cccggcaccg agctgaccgc gaccgcgctg gcccgctcgc
     2581 tgcggctggt gctgctggcc ctgcccacct cactccggca gggcccgcac tatcgggcgg
     2641 cgcaggcccg gatcgcctcg gtgtgtgacc gaacggccta gtgggtatcc ccccgcgggg
     2701 gtcacccgga aaggcaggcc atgagcgcac ccgaatcgaa gcccacccga gcccagggcc
     2761 cggacctggt ggaacaggga cccgaagacg ccgaggtgct cttcgtcctt gatccagcgg
     2821 gcctgggcag gcacggccac ctgcctgcca gctggcgggg catcgcccgc tccacgcaca
     2881 tcgcctggct gcgcctgccc gccgccgagg ccgccatgcc cagggccagg gacgtgctgg
     2941 aacgcctggc cgagggcggc ggcccgatcg acctggtggc cgagggcgcg gccgccgaac
     3001 cggccatgct gctggccacc gagtccttcg ccggtggcga ggccaggcag gtccgctcgg
     3061 tgctgctggt cgacccggaa ccccggtccc ggccgatcga gcagatgctc atcgggcacg
     3121 gggtccgggt gaaggtgctc gaccgcggcg tcgcgccggt gccgctggga catccgcggg
     3181 tggcggccga ggtcgcgggg gagttgcacg gccgccggat gcccccgcgg gcccgcggcg
     3241 gcacccggcg gccgtcggtg gccggtcagg tgtggcaggc cgtgcggatg cggatcaggg
     3301 accggctgac ccggtcccgc tgacccggtc ccgtttaagt ggctcagact cggccgctgc
     3361 cgacgacgcc gtactcgtag gcgaagacca ccgcctgcac ccggtcccgc aggtccagct
     3421 tggtcagcag gctgctgacg tgcgtcttca ccgtgtgctc tgacagcacc atggccttgg
     3481 cgatctccgc gttggacaac ccgcgggcca ccagctccag ggtctgcgcc tcgcgcgcgg
     3541 tcagcgtgtc cagccgcggg tccgggttgt ccggggtggg ccgcagcgcg cggctgacca
     3601 cgtcctgcac caggcggcgg gtcatcgacg gggccagcat cgcctcgccg gtgaccacca
     3661 cccgcaccgc gtgcaccagg tcgtcccggc gcacgtcctt gagcaggaag ccgctcaccc
     3721 cggcgtgcag cgcgtcgtag aggtactcgt ccaggtcgta ggtggtcagc atgacgacct
     3781 tggcctcggt ctcggcgcag atcaccctgg ccgcctcgat gccgtccatg gtgggcatcc
     3841 ggatgtccag caacaccacg tccgggcgca gcatccgggt ggcgaagacc gcgttcgcgc
     3901 cgtcctcggc ctcggccacc acctcgatgt cgggctggct gtccaggatc agccggaagc
     3961 cggcccgcac cagctcctgg tcgtcggcga tcaccacgcg gatcggctcg acgctctgct
     4021 cgctcaccac ggtcaactcc cccgttctac ccggctcacc gggaagtcct tgtgcgccag
     4081 cggaatctcc gccgtcacca tgaacccgcc accttcgcgc gggccgatcc gcaccacgcc
     4141 accgcaggcg ccgacccgtt ccctgatccc gaccagccca cgtccgccgc gaccgggcgc
     4201 cggactgtcc gcgccgatcc cgtcgtcgag caccagcacc gccagctcgg cccttgacca
     4261 gctcagccgc acctcggccc ggccggcccg agcatgccgg acggtgttgg tcagtgcctc
     4321 ctggatcagc cggtacaccg ccagttcggt gtccggcggc agcggcgccg gggcgcccga
     4381 gacgctgtgc tccacgtgca gtccggtggc ccggaccgtc tcgatcatcc gcggcacgtc
     4441 gtccatggtc ggttgcggcg cccggcgcag ctcggccgga tccctcggca ccatcccgag
     4501 cagccgccgc agctgggcca tggcgtcccg gcccgcggtg gcgatggcgt cgaaactggc
     4561 ctcggcgcgg gccggatcgg cgcgcaccac cagcggtccg gactcggcct gcaccacgat
     4621 cagcgccacc gcgtgggaga ggatgtcgtg catgtccctg gcgatccggg cgcgttccgc
     4681 gctggtcgcc cgctcggcct ccagctgctg ttcctgctcc agccggtgcg cgcgttcctc
     4741 cagcgccacg gtgtaggcgg cgttcgtgcg caccgcccag cccaccaggt aggcggtcac
     4801 cgagcaggtg gtcaggaagg tgaactcctg gaagtccatc tggtcgagcc cggagtgcac
     4861 caccaccgcg agcagagcca gcgccagcgt gatccggcgg atcagcggct cgctgttcct
     4921 gctcaccgtg tagacgccca ccagcgggcc gtagatgctc cagatgtcgg gcaggtccag
     4981 cgcgatgtag accagctcgg ccacgctgac cgcgatcatg gtcagcatcg gcgcctgcct
     5041 gcggaacagc aacggcagcg cggtcgaggc cgcgaccagg taaccccacc agggcggcgg
     5101 gccgccgccg aggccgaagc cgagcggcag ctcgaccgcg agcagcacga tcaccacgac
     5161 cagcaggtcc gcctgacgag cactcaggtt ttgcagcggg cgcggcggac gccagccgag
     5221 cggtgtggac atgcgggctc cgaaccactg cgcgaccagg gcagtacccc ccaacctacc
     5281 gccggtgtgc gcgctgaggt caggggcgtt cgggctgctg ttctgccggt tctgtgggtc
     5341 cgggtggttc gggtggttcg ggtcctggtg gccgagttgc cacggcatcg cccggatcgg
     5401 ggtccgcgaa gaggtagtcg gtggcctgct cgccggcgaa gcccccggcc gcgcccgccg
     5461 cgaccgttcc gagttcgccg cctccaccca gttcctcctc ccccgaccgc tgcgcgaagc
     5521 agaccagcac tgtccgcctg acctgcggtg acagtcgcgg ccacaccgcc gcgtgcactt
     5581 cctccagccg cggcagcggg gtgccggcca gcaacgcgcg gtactgctcg accgagtagg
     5641 cgccggagtc cggcgcaagc ggagcggaca ccgcgaccac cttcctgggc acgcacgcca
     5701 ggtctgcccc gtcagcgtcc ccggaacgcc gcccgcgcac ctcggctacc ggtggcgagt
     5761 tcggcacccg cgatggaggt agcccccgga aggattccga cctggggact aggccgcatg
     5821 gcgtcctcag agcgagggtt gtccggacaa ccggccattg tggactcagc ggcggcgcgg
     5881 tttgggtgtc tgttgtggac ggtcaacccg ccgaacggcg gcgtttgtgc ttgttgtcct
     5941 ggtacgcggc cacggccttg cgtgaacttc gccagacccc gtctggccct tgcacggcgt
     6001 cgagccgacc gcgccgcgct gcctggcgca gcgcggcgag cgtgaaatcc tcggtcacca
     6061 gcgcggcgag cgggaccagg cgagccgggc ctgccatgtt gggcacgatg aacctgttga
     6121 ggttgtcgta catggcacgg gcgatcagtt cgcccagtgc gccgtagtca ccgctgtcgg
     6181 ctcgttgcag tgcagtgaga taggcatccc gttgccgctt gaagatgacc accggtggat
     6241 agccgagccg gaccaggacg aggttgagga ccagccgtcc ggtccgcccg ttgccgtcga
     6301 gaaacgggtg tacccgctcg aactcgttgt gcagccgggc cagttcctcg gtcagcggca
     6361 ggtccgcctg cccgttggcg ccgatgcctc gccctgccag gcagacagcg tccacccact
     6421 gttgcatcag aaccggcacc agcggccagg ccgggggcgt catgcctccg gagaacggct
     6481 ggatgtcgtg ttcccggaaa cagcccggtc cctcccggtc agtcgcgtcc ttgtgcgggg
     6541 ccacgtccca caccggcgtc atggcggtgt ggtggattcg ccggacctcg ctgatggtca
     6601 gcagccggcc gtcatgccag ctgtcgggtt cgagggcctg gcggtacacc cagcgggcgg
     6661 catcggcgta gccgcgcctg aacctcgcgc aacaccagtg tgttgccctc cagcgcggtg
     6721 gagtggtggg cctccagatg ccagatgtcg tcccagatcg attgggcttc cttcgggctg
     6781 ggcaggccac cgaatcgggt gtccagttca gtcagggcgt gttccagccg ccggtagaca
     6841 ctggcccggc tcggccgtcc cctgcccgcc acgactgctc cgcttctggc ccgcaccagg
     6901 cccagctcac ctcgccgcga gtttgataca cctgcgcggc atctaaatga actgatcaaa
     6961 taggagcgag ctgttactca gcggcacatg atgttgcaga gagtgtcagt cttctagttc
     7021 actcgaaggc tggtcagcag ggccgcgtgg tcggagtaga agacgcccgg cccgtgccgg
     7081 ggcagccggg tgtccagcac ctggctgccg gtgaccaccg cgcccctggc gaaggtcagg
     7141 tcgatgcgct gcggtgtgat catccgctcg gtgggctgcg ggctccaggt gcggccctcg
     7201 gcggtgcacg ggctggggtg cgcggcgcgg aaggtgtcgg tgaagcccgc ttcgacgagc
     7261 agatcggtgg tgcgcagcgg gtaggccatg ccgaagtggt tcgggcagtc cttccacttc
     7321 tcggtccagt cgctggccgc cggggtgttg aagtcgccgc cgagcacggc cgggcccgca
     7381 ggcaggtgcc gggcgatgat ctcggacagg tagccggtct gcgcggtttc cgccgcggcc
     7441 accgccgccg gggtgtgccg gggtggcaga ccggcgcgga tggcggcggc gttctcgtcg
     7501 atcaggtagc cgctccacgg gtcggtgtag ggcagccagg tgtcgaacag gttcagcggt
     7561 cggccgccgg gcagccggac ctggacgccg ccgaagttga acgcggtgac cttgccgccg
     7621 ctgggcgcgg ggtaggtctt ggtcaccggg tagcgggtga agatccacag gttgtcgccg
     7681 ccggtggtgc tgggcgtgat ctgggtgccg gagtaggcgc ccttgcccgc tcgccgggtc
     7741 agcgcctggc ggatctgctc gcccgcgccg taggtctcca ccgcgagcag cacgtccggg
     7801 cgcaccgcca cgatctggtc cagcagccgg ggcaggttgt ccgcgcccgc gccgagcccg
     7861 ccgcgccaga tgttccaggt gagcacccgg acctcggcgg gagcggcctc ggccggaccg
     7921 gccaggccga gggtgagtgc caataccgac atgaccagtc gtgaccaccg catgcgcgca
     7981 ggctaacggc ggcaggtgaa cggtgggtgc gggcgagtgc ggtggccggt ggatcgctgc
     8041 cccccagagc ggcaatccac cggccaccgc aagaaaaccg cgttccggca gccaggggaa
     8101 ctcattcgaa cccgctcgaa tccgcgctat gttcggccgg tgatcctgct gcgatgcgac
     8161 gccacgacgg tggcgaacat ccggctgtcg cactcgccga tcatggaggc ggtcacctgg
     8221 ctcggcctgg ccgccggtgg tggcaggcat cccgtcttcg gcgatcccgg cgcgctggcc
     8281 agggacgcgc tcggcgcggc cgaggtcgag ctggtcaccg atctgctgcc gctggacggc
     8341 aaccactaca ccccggacct gctcacccca caaccccggc cgggcagctc cggcgaggcg
     8401 ctggaggcac agctcaccga cctggccgag acctcggcgg aactggtggc ccagcagctg
     8461 ggcttcgccg agaagcactg gcggcgaccg gtgtcgccgc gggtgcggcg gctggcggag
     8521 accggcaggc tggccgggcg gctggcggcc gggctgggca ccttctggcg gcgggcgctg
     8581 gccgagggct ggggcgagat cgaggcgctg gccgacgccg acctcgccga ccgggcccgg
     8641 ctgctcgcca cccgaggggt cggcgagctg ctcgccaccc tcgatccgag gtgcagctgg
     8701 accggcgcgg cggtggcgat cgacaagccg ttccaggtgg aggtcaacgt gtccggccag
     8761 ccgatcgtgc tggtgccctc ggtgctcagc tggccgaagt tcatgatcca gtgcgatgac
     8821 cagcagcagg tcgcgctgta ctacccggcc gccagggtcg gcgtgcgggc ccggcgggat
     8881 ccggccgagc tggccagggt ggtcggcgcg accagggccg cgctgctggc cgacctgggc
     8941 gcgccgcggt ccaccgccga gctggcgctg cggcacaagc tggccgcggg caccgtgtcc
     9001 taccacctgg gcgcgctgcg ccgggccaac ctggtcaccg ccagccggga cggccggttc
     9061 gtgctctacc agcgcagcgc gcaggccgag gtcctgctgg cggcctccta aagctcgaac
     9121 agcgtcccgt ccggcggtgc ggacaccccg gcggtcagca cctcggcgtg ttcggccgag
     9181 gccgggtcca gcaccgggtt ggtgttgttg aggtgggtca ggatccggtg cttgccgggg
     9241 aaacgggaca gcacgtccag tccgccgccc ggaccggcga tcgggatgtg ccccatggac
     9301 ttctggtccg cgtcggcctt cttgccggtg gcgccggaca tctccgcggc ggagtggaag
     9361 gtgccgtcga tgatcacgca gtcggcgtcc gcgacgaact cgtcgaagcc ggcaggccac
     9421 tcgcgcaggc agggcgcgta gaccagcgtg ccgccggtgg ccgggtcggt gatccggtag
     9481 gccaccaccc acggtccgtc cattgtggac gctgccgcgt accggggccg cttgccgctg
     9541 accgggaacg cggtcaccgt cagctcgcct gccgggtgca ccggcacgcc gggggagacg
     9601 gtgtgccagt cccagcgccg gtagtgctcg acggtgccgc gcaggccgaa gtcctcggtc
     9661 agcccgtgca gcaccgcttc cggcgcccac acctggaggt tgtcgccctc gcgtagcagc
     9721 atcaggccga gcgagtggtc cagttcggcg tcggtcagca gcaccccctt gaccggggtg
     9781 tcccgcggcg gcttcgggcg gaactcctgg tgcgccagca gttgcgcccg gatgtccgga
     9841 ctggcgttga ccaggaacca gcgttcgccg gtggcgctga ccgcgatgcc gtcctgggtg
     9901 cggtgggtca gcaggccgtc ccggccggcc gagcacatcc ggcaggcgca gttccactgc
     9961 gggaaaccgc cgcccgccgc cgtgcccagc agcagaacct tcatcgtgct cctcgttcgg
    10021 cggccggcca gcgcatcgcc agcggcgcgt ccagcggctc gggcgcctgg tggtggcggg
    10081 ccaggatggt gtcgatgagc ggccggtccg gggacttcga gcacaccggg tcggtggccg
    10141 ccgcgtcgcc ggtgagcagg aacgcctggc agcggcagcc gccgaagtcg gtctccttgc
    10201 gcgggcagac ctggcaggtc ggactcatcc actcggtgcc gcggtaggcg ttgaaactct
    10261 cgccctggta ccagatctcg gccagcggcc ggtccttgac gttgtccagt ttgagcgtgc
    10321 tgatcgcggt ggccgccggg cagggcagca catccccgtt gggcgctacg gtgagctggc
    10381 gcgcgcccca gccgtgcatg cagggcttgg ggtagtcctc gtagtagtcg gccaccacgt
    10441 agaccacctg catccgcccg gccagccgct tgctcgccgc gcgcacgatc ggctccgcgg
    10501 tggccagttg ttccctggtc ggcatcagct tggcccggtt cttcagcgcc cagccgtagt
    10561 actgggtgtt ggccagttcc agccggtcca cgcccatcga ctcggccatg gtgatgatct
    10621 cgccgatccg gtcgtggttg agccgggtga gcaccacgtt cccggtcagc ggcagcccga
    10681 ccttgtgcac cacctgcgcc gcggccagct tgcggtcgtg cgcgcgggcg cctgccacct
    10741 ggttgccgcg caccggatcg gagtcctgaa tggacagttg cacgtgcgcc agtccgcgat
    10801 cggccaggtc ttgcagcacc ggctcggtca ggccgagccc gctggtcacc aggttcacgt
    10861 aacagccgag gtcgctggcg tgctcgacca gctcgcggat gtcatggcgg gcaaggggtt
    10921 cgccgccgga catgtgcacc tgcagcacgc caagctcacg cgcttgggtg agcaccgagc
    10981 gccactgatc ggtggtcagc tcgttgttct tggcgatcag ttccagcggg ttggagcagt
    11041 acgggcagtg cagcgggcag cggtgggtca gctcggcgag catgcccagc ggggcctcgg
    11101 cgggggacac cgggatctca gacatcggcc accgccagct ccacgatccg ccgctcgatc
    11161 agcgcggcca gcaacccggc cacatcggcc accgaaaccc cttggtagcg ctcggaaagc
    11221 agcttcacca ccgcgtcgac gtcgttgacc ccgtcgcagt gctcaagcac cgcggccgcg
    11281 gtcgggttgg gcaccagcac gccctcgggg aagagcagca cgtgcgtctc gcgcaccttg
    11341 tcatagctga gccgcacacc gcggcgcagc ctcggccggg aggtcccggt gatctcgctc
    11401 atcggggtca gcccttcgtc gcggcgcgct cgatcgaatc cagcaggctc cacaacacat
    11461 cgcacttgaa gctcagcgcg gccaccgccg cgtcctggag ttccctgctg tcgcagtgct
    11521 ccagcaccag gtccacggtt tccttgccct cgccggagac cttgtcgatc cgggtggtga
    11581 agtaggccag gtcctcccgc cggatccagc tgtacccggc cagcacatcg gaaacccgtt
    11641 ggcgcatcag gtgaccggag aacatctcgg tcagcccgga ggccacgccg atgatccacg
    11701 gctgctgccg ggcgaagttg acgtaggcgt ccaccgcgaa ccgggtgccg ggcgcgatgt
    11761 gccgctggtc cagcacttcc tcgcgactga gaccgacggc ctggcagagt cgcagccagc
    11821 tctccgcgcc gccctcgccc tcggccttgc cgtcgtggta gacgatccgg tccagccaca
    11881 gcctgcgcac ctcgggcagc gggcagttgc tgatgatcgc cgcgtccttc tgcggcagca
    11941 tgcactggta gtaccagcgg ttggccgccc aggtccgcag ctcgtgttcg gtcagctcac
    12001 cggcgtgcat ccgctggtgg aaggggtgcg ttccccagta gcgatgggac agagcctgca
    12061 acgcggcgag gaagtcctca cgcgacaaca catcctggct ggtggccatc tccgcactac
    12121 ctctcgagaa cgactggcga cagtgctggc ggcggcggag gcgggcaggg agccacaggg
    12181 ccgtggctcc ctgccctgga tgagcatcag tccatgcggg ccgcgtacgc ggtgacctcc
    12241 atgggcgtgt cgtactcggt gaattccgga cgggtccaca cttcacgagt ttccataacg
    12301 ctcactcctc ggatcacggg cggtccgccg ccgaaccgcc ctctcctgtg ctcatggcga
    12361 gcgacaccac gctagacacg tttttcttga tcccgctatg ggccgatcgt atttttcagg
    12421 gaactttcca gacggcattg acagccctag cggtaagcgc ttgccttggg ttagggtcgg
    12481 acccactgca agcgtttaca tccgacgctg tgccgccacc cttgccgccg ccgtttccgc
    12541 actccacagg catgatcagg aggggcacga tgcacgctcg acgcaggaca gtcatcggag
    12601 cattggtcgc gaccgccacc gccgcggccg cgttcaccgc accggtcgcc acagcgtccg
    12661 aggtctcccc gatggcgatc aaacagatcg cctccggact caatcaggcg tgggcggtgg
    12721 actggctgcc cgatggcacc gcgctgttca ccgagaagga cagcaagaag atccgcaaga
    12781 ttgacaaggc gggcaaggtt tccgacgttc agaccatccc cggggtgagc gtcaccaagg
    12841 aagccggcct gctcggcatc gcggtctcgc ccacctacgc ggccgaccag ctggtcttca
    12901 tctactacac caccggcagc gacaaccgga tcgccaagct caagctgggc caggccccgc
    12961 agccgatcgt gaccggcatc ccgcgtggtt cccagttcca tcacggcggc cggatcgcct
    13021 tcgggccgga cggtttcctc tacgcgggca ccggtgacgg ccagaacggg gccaacgcgc
    13081 agaacaagaa ctcgctgggc ggcaagatcc tccggatcac caaggacggc gcggccgcgc
    13141 ccggcaaccc gttcaacagc cgggtctaca gcttcgggca ccgcaacgtg cagggcctga
    13201 cctgggtcgg cggccagctc tacgcctcgg agatcggcgc cagcaaggtc gacgagctga
    13261 acaagatcga ctccggcaag aactacggct ggccgaactg cgagggctcc tgcggcaccg
    13321 gcggcatgac caacccggtc aagacctggc cgacctcgca ggcgaccccg agtgggctgg
    13381 cccactacaa gggcagcctg tacatcgcct cactcaaggg tgggacatac aagacaaata
    13441 ccagtggctc cggtggcaag atctacacca acctgggccg cacgcgcgcc gcgaacgccg
    13501 cgccggacgg ttcgctgtgg atcatcaccc ctggtgggat ctacacctct gacggcaact
    13561 gaccaagccg tcactcgaac agggggcccg tgacctggga ccggacacgg gcccccgccc
    13621 acatccgcag cacgtgccag gagttcgcca tgcccgttgc ccggctcgcc gcgctcgccg
    13681 ccgcggtcac cctcggcctg ctggccgcga ccccggccca ggccgccacc cggccaccca
    13741 ccgaggtcac cggcgggctg gcggtgccct ggggcgtcgg cttcctgccc gacggcagcg
    13801 cgctggtcac cgaacgggac accgcccgca tcctcaccat ccgcggcggc aaggccaccg
    13861 aggtgcagaa gatcgccgac gcgcagccca ccggcggcca cggcggcctg ctcggcctgg
    13921 cgatctcgcc gcactaccag cgcgatcgca cggtgttcgt ctactactcc accaagaccg
    13981 acaaccggat cgccaagctc cgcctcggcc agccgccggc gccgctggtc accggcatcc
    14041 cgctgggcgt caagcgcaac ggcggcaggc tcgccttcgg cccggacggc cacctgtacg
    14101 ccaccaccgg cgacaccgcc cgcccggaac tcgcccagga cccgaagtcc ctggcaggca
    14161 aggtcctgcg actgaccacg accggcaaac ccgtactcgg caaccccttc ggcaccctgg
    14221 tctactccta cggccaccgc gacccgcagg gcctcacctg ggaccgcgac ggcaggctgt
    14281 tcctggccga ggctggcgac acccagtggg acgagctgaa ccgggtgctg cccggccgca
    14341 actacggctg gccgctctgc gagggcaagt gcggcgaccc gcgtttcatc gatccactcg
    14401 tggtctggcg caccgaggaa gccaccccca gcgatctcgc ctactacaag ggcagcctgt
    14461 acgtggccgg cctggtgggc cagcgactct ggcaggtgcc gctgcgcgac ggccgtactg
    14521 gcacgccgaa agccttgtac cacaaggagt tcggtcgcct gcgcacggtg gagcccgcgc
    14581 cggacgggtc actgtggatc accacctcca acgcgcccgc gccggaccgc atcctgcgca
    14641 gcgagggcta gcgcccaagg aaatcggtga tccgggattc gtcccaggcc ccgtcggcga
    14701 agaccaccgt gtagcgcagc gcgagctgtt cgcccggcgg caaccggact tccgcgctgt
    14761 agaacggcgc cgggcacagg ccggggtagt ccgagctgcg ggcgaaccac tgggtggggt
    14821 ggccaggatt ctctggtgag tccacaaaaa gcaccgtcga gtgcgtgccg gtctcgtcct
    14881 gccgaccgat gtaggcggcc cagctcgccc tggctcccat cggattgcgc gcaccgggca
    14941 ccagcacccg gccgccgagg aattccctgg ggccgcgcca gaacaggccg ccgtagccag
    15001 cgtccgggcg gccgttggtg ctcgggctgc cgaagcggat cgaggccgcg gtggtgttgc
    15061 gcagccaggt gtcgaaggtg agctgccagg cctggtcagg ggctgacacg gtgacctgga
    15121 cgtggcggcg ttcggccagt agttccgcgc cggtcgcggt gcgccagctc aggcgttggc
    15181 gcagctcgaa ggtggtgccg gtgctggcca cctggtcgaa accgaggtgg agctggctgc
    15241 cgttgttggg caggtccacg tacccggcac cggcgcggta ggtcgggccg ccccagaagt
    15301 tggtgtcgtc cacgtgcgcc accgcgagtt gcaggccctt gtgccaggtg tggtccgccg
    15361 ggcggtagtc cgagaccagg gcgccgcgca gggtgcgcag tgggtggaag tacggcttcg
    15421 gtgattcccg cggcgggtca tcggggcggt agtggtagct gagcagccgg acgccggagt
    15481 ggaacaggtc cacggatcgg tcgggcacgt gccgcatggt cagtgcggtc atcggcgtat
    15541 ccgcctcgga gtcggaaaaa ggctttccgg ccgttcggca acggccggaa agccctgttt
    15601 cacccgcgtt cggcgatgat gatccggttg tcgtcgtaac ccagcctgcc gccgatccac
    15661 tggccaccac aggtcaccag caccagccgg tggttgccgc tctgggcgaa caacgactcc
    15721 gcgcgctgcg gcagctggtc cttgtgcacg gtgtgcactt cggtgatccg gtaggtgtag
    15781 gtcttgccgg tggcgtcctt gacggtgacc tgctggccct tgtcactacg ccagagctcg
    15841 gcgaacggcc cggtcgagcc cttccagttg acgtgcccgg ccagcaccgt ggcgcccttg
    15901 gccgagtcca ggccggcgcc ccaccaggtg gcgtcccgga tcccgtcggg caccggcagc
    15961 accccgtcgg gggccacctc ccggcggacc agggtggcgg tgccgccctc gggcagccgc
    16021 accgtgccgg gtcgctgccc gccggccggc tgcacgatct ggttgggctg acccggtttg
    16081 gccggggtgg tggtctgcgc cgggttcccg ccgccgggct ggccccagcg gatcagcggc
    16141 gcgtcgccga tatcggtcag cgggcgggcc cgcagtggag acggtggcgg ggactccacc
    16201 gccaccggct cgccgaccac cgtcgtgctg agctgggagg cgccgagtcc ggccgccacg
    16261 cacaccgcgg ccaccccgag caggccgagt ccggccatcc gggcgcggtt gtcgcgtttg
    16321 gtctcaccgg gatacagcga tctccccatg ggtcaccgct ggtgcagacg tcgacgcaga
    16381 gccatgacgc ccagggtagc catgaccagc gtgaaaatgg cgaatccgac cagtcccgcc
    16441 ggttccacct gggtcacggt ggccgcctgg gccaccggca ggtcgggctg gtcgcccgcc
    16501 gggatcaccc tgggcaccac cggtttcttc ggcacgttgg ccttgttggt cagcgacaac
    16561 gccagggtgt tgcccggcgc gaccgtgccg cagaccgtcg gcggcttctt cgggtcgaag
    16621 ccctcctcat agcccttggc cgggatcagc tcgatcaggc agatctcctg cggggtgcgc
    16681 aggtcggcca cggacacctg gccgtcgtcg ccggtcttga ccaccagcgg cttgccgtcc
    16741 acgccggtca gcggggaacc gtcctgcttg agcgcgggcg cttccttgtc cggcccggtg
    16801 atccgcagcg tcacgccggg gatggccgcg ccactggccg cgtccacctt gccgatcttg
    16861 acgatgcccg gctgggtcac cgcgggcacg gtggcctcgg ccgagatcgg ggtctgcccg
    16921 ccggtggtca gcgcccgctg cgcggtgggc ttgttcggca gcagcagcac cggatcggcg
    16981 ttcgggctct ccacggtggc caccaacttg ggattggggc ccttcggggt caccgcgatg
    17041 accagcggtt tgccgcctgc cggcgtcttc acggcgccgt cactggcttc cccggccagt
    17101 tcggcgtcga tcgccttcag cttgaccggc acacccgaga ccggctgacc cttggccgag
    17161 gtgaccgtga tggtccagtt ccccggcttg ccgatcagct ggccgtcctt gggcgcggcc
    17221 acggtcagtt tccacggccc gtagtgcgcg tccgcgtccg cctgcaaccg gcccacggcc
    17281 tgcctggcct cggccgacaa cccgttgagg tggaagtcga cgtcgtagcc gatgcgggtg
    17341 aagttgttgg tcttggccag cagcttcggg tccttggtgc ccgaggtcca gctgtgcagc
    17401 aggtgcgcca gcgcggcggc ctccggtttc gaggcggtgt cctggtagcg cagcagcagg
    17461 taggagatct tggccttggt ctcggcggga atcggggtgt tccacttggt ggtcagcccg
    17521 tccttgctgg gcgtgtactc gagcgcgtca cccggttcgt cgagggcgta ccggacgcac
    17581 cacacctgcc ggccgcgcca ggtgtacgag ccgatccagt catccccctt ggggcggccc
    17641 tggtactcct gaggcttggt gtactcaccg ctgcgctccc cggcggccag tgccgaaccg
    17701 ggtatcgcca gcgcgaggcc gccggcggcg agcgtcacgc tcatcgcccc gaccagcaga
    17761 tttctaaggc ctggcatgaa agctccttgc ttgctacggc ctgtcgccac gcatgctggc
    17821 ggccgtcccg ggcgagtcgc aatcggcctt tagaactaag caagcaggtg actgtgtggt
    17881 gtctctcacc ttgacgtcta gaccattcgg cgcatcgcgc tgatcttgtc ggcctacgtt
    17941 ccccccacga tcggactcgt cctcataacc cagagcgaag acgggggtgc tcatgggacg
    18001 atgcgggagc gagtaaagtc agctttacct gtcatggaac cggtccgcgc cttcggacgt
    18061 tgaaccggat gacggcgcga gcacgctcca ggaggaccag gtgcgcacta gcagtaaccc
    18121 ggcgttccgt aacctgcccc accaggggtc tggctacgcg acgttcaaca ccggcggcca
    18181 gcccgccggc taccaggctg gctaccagca gcagcccggc taccagcagt acgattcgcg
    18241 gcccgggatt tccgagcgtc cgatgaccgt ggacgacgtg gtcatgaaga ccgccacgtc
    18301 cttcggtgtc actctggtcg ccggtttcct gaccgccttc ttccaggcct actacctggc
    18361 cctgcccgcg gtgctcatcg ggctgggtgt cggtctgttc ctgtcgttcc gtccgcggcc
    18421 ttccgcgccg ctgacgctga cctacgcgtt gtcccagggc gtggcactgg gcgcgatcag
    18481 cgccctggtg aacctgcgct tcccgggcat cgtggtgcag gcgctgatcg gcaccgccgg
    18541 cgtgttcgcg ggcatgctgg tcgtctacaa gaccggtgcg atccgggtca cgccgaagct
    18601 cacccgctgg gtgatcggcg cgctggtggg cgtgctggtg ctggtgctgg cgaacctggt
    18661 cgcgagcttc atcgtgcccg gcggcctcgg cctccgcagc ggtggcgcca tcgcgatcat
    18721 cttcagcatc atcgtgatcg gggtggccgc gttcgcgctg ctgctcgatt tcgaccaggc
    18781 cgacgagatg atccgctccg gcatggacgc caagtgggcc tggtacgccg cgttcggcct
    18841 gaccgccacg gtggtcatgc tgtacttgga gatcctgcgc ctgctgagct acttcaggca
    18901 ggactgacgc tccggctcag tacctagaca cgaggaaggt ccccggttcg ccgggggcct
    18961 tcctcgttgt ccggggctgg tcagctcagc tgaggcgctc cagcaccatg gccatgccct
    19021 ggccgccgcc gacgcacatg gtctccagac cgatggtctt gtcgtgccag gacagcgagt
    19081 tgagcagggt ggtggtgatc cgggcgccgg tcatgccgaa ggggtggccg accgcgatcg
    19141 cgccgccgtt gacgttgacc ttttccagcg ggatgcccag gtcgcggtag gacgggatca
    19201 cctgggccgc gaaggcctcg ttgatctcga ccaggtccac atcgtccacg gtcagcccgg
    19261 cccgcttgag cgcctgctgg gaggcctgca ccgggccaag gcccatgatc tccggggaca
    19321 gcgcggacac gccggtggag atcaccctgg ccagcggggt gatgccgagc tgcttcgcct
    19381 tggtgtcact catgatcacc agggcggcgg cgccgtcgtt gagcggacag cagttgcccg
    19441 cggtgatccg cccgtccggc cggaacaccg gctgcagggt ggacaccttc tcgtagctgg
    19501 tgcccgcccg cgggccgtcg tcggtgctga ccacggtgcc gtcggccagt tcgaccgggg
    19561 tgatctcgcg ggcccagaag ccgttggcga tggccttctc ggccaggttc tgcgagcgga
    19621 cgccgaagtg gtccatgtcc tcgcgggtca cgcccttggc cagggcgagg ttctccgcgg
    19681 tctggcccat cgggatgtag acgtcgggca gcagcccgga ctcgcgcggg tcgacccatt
    19741 cgctcgcgcc gtgttcagcg gcgtgctggg tgcgcgcctg cgcctgcgcg aagagcgggt
    19801 tctgggtgtc cggccagccg tcggagttcc cgcgcgcgta gctggagacg atctccaccc
    19861 cggcgctgat gaagacgtcg ccctcgccag ccttgatcgc gtgcagggcc atccgggtgg
    19921 tctgcaggct ggaggcgcag taccgggtga cggtggtgcc gggcaggtgg tcgtatccgg
    19981 cgagcacggc caccgcgcgg gccatgttga agccctgttc accgccgggc agcccgcagc
    20041 ccagcatcag gtcgtcgatc tcccgcgggt ccagctcggg caccttcgcc agtgcggcct
    20101 tgaccatctt cgcggtcagg tcgtcggcgc ggacatcctt cagggagccc ttgttggcgc
    20161 ggccgatggg ggagcgggcc gtcgccacga tcacggcttc aggcatgtcg agaactcctt
    20221 tgttcgcctg aagcgcagcc tactgtccgg taacggcggc ggagtgtgac gttgccgggg
    20281 gcacccgctt gagccgccgg ttgagcccgg ccaccagctt cgcggtgggc cgccgggcct
    20341 cggcggcggc cgaacgggtg ggctgggcgg gcagcggacc gccgtcccag acccgggcgg
    20401 ccacgcacag ctcgggcagc agcacgccca ccgcggcggc gtacccggcc gcggagggat
    20461 ggaacatgtc cttgctgaac agctcgctgg gccgggtcag gaactccggc gagagcaggt
    20521 cggccagggc caccggccgc ccgcccgcgg cctgcacggc ccggcgctgg gccctggcca
    20581 gggtgaggct ccaggagcgc accagcgcgc gcagcggctg cgcgatcggc cggatcgcgc
    20641 ccagatccgg gcaggtgccc acgaccacgg ccgcgccggt ctcggtgagt ccgcgcaccg
    20701 cggcgcccag catcagcgcg caggcagccg gtcccagccg ggcggtcacg tcgttgccgc
    20761 cgatgatcac cagtgccacg tccggcgggg tgcgcagcgc ggcctcggtc tgcccggcca
    20821 gctcccggct ggtcgcgccg ctgatcgcgt gggtgagcag ccgcaccggg tgctcggact
    20881 cctcggccag cccgcgggcc agcagcactc cgggcagttc ctcggtggtg tcgcagccga
    20941 ccccggccgc ggaggagtcg ccgagcaccg cgaagaccag gggatcgccg gtgatccgcg
    21001 ggtcggtcgg cgcgagcggg ccgctgccgt ccggcaggta cacgccgtcg gcgcgcagcg
    21061 gcgccgccgg cactccgatg atcttccgag cccgtttgga ctgctcggtg agcagcccgt
    21121 acgcggcgcc ggacagtccg ccgaccgcac ccgcggtgaa gaccgcggcg cggagaatac
    21181 gaagtccgaa cacggctcgt gcctcccctc cgcctggtgg ttcccccaat ggccccacac
    21241 accagttgtt cacccagtgt tccgtacata aggccaaacg ggttaacgga gggtagatgg
    21301 ttttacttcc cactttcggg tgaggcaaac aaattcgaag ccgcccaacg ggattagcct
    21361 gatcgtgagc ttcgactcag gcgcgttcgg ccgagaaggg gacctcggcc cggtgcagcg
    21421 ggtcgtcgta gtgcccgagc agcgcggaca gctggtgacc gagcccggcc agcgggaacg
    21481 ggatggcctt gccctcgaac tccggctcca gcagcgcggg ctccagcagt tcggcgccac
    21541 gcccgaaggt cagcgcgaac aggcggccgt ccacctcggc cagcagggcg gagtcggcgc
    21601 cgcccgtccc ggccagcgtg aagtgctcgg ccagctcctc cggacctggc tcgccgtcct
    21661 gcgcgcgcac cgccagcgca caggagaagt ccagctcagt gcgggggagc aggcacacga
    21721 tgtccggcgt gccgcggccc ggcagggtga gggcgtcccc gaaggagagg gcgtcggtgg
    21781 tgaacaggtg caccgtgagt ttcatggcta cccccgacgc gagaccggct cggaacggat
    21841 ctttccgaca ggccaagaat acgtgacctg gcggtggacg agggtgtcca agagtggccc
    21901 gtgccacgga gtagcagcga tcgggtgacg ctgcgccagc tacgctgacc cggacgtctc
    21961 aactactggg aggaccgcgc ggtggagtac gccgagcacg tgatggacct ggtcggcaac
    22021 accccgctgg tcaggctgaa ctccctgacc gagggtctga agccgctggt gctggccaag
    22081 gtggagtacc tcaaccccgg tggcagcgt
//
