LOCUS       NZ_CP095462            23917 bp    DNA     circular CON 27-JUL-2024
DEFINITION  Ectobacillus sp. JY-23 chromosome, complete genome.
ACCESSION   NZ_CP095462
VERSION     NZ_CP095462.1
KEYWORDS    RefSeq.
SOURCE      Ectobacillus sp. JY-23
  ORGANISM  Ectobacillus sp. JY-23
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Ectobacillus.
REFERENCE   1  (bases 1 to 3893080)
  AUTHORS   Peng,S., Li,H., Zhang,S., Zhang,R., Cheng,X. and Li,K.
  TITLE     Isolation of a novel feather-degrading Ectobacillus sp. JY-23 strain
            and characterization of a new keratinase in the M4 metalloprotease
            family
  JOURNAL   Microbiol Res 274, 127439 (2023)
   PUBMED   37364416
REFERENCE   2  (bases 1 to 3893080)
  AUTHORS   Li,K. and Peng,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-APR-2022) College of Biological Science and
            Engineering, Jiangxi Agricultural University, 1101 Fangzhimin
            Avenue, Nanchang 330045, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: flye v. 2.7
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 10.0x
            Sequencing Technology             :: Oxford Nanopore PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023022965.1-RS_2024_07_27
            Annotation Date                   :: 07/27/2024 02:48:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,932
            CDSs (total)                      :: 3,788
            Genes (coding)                    :: 3,713
            CDSs (with protein)               :: 3,713
            Genes (RNA)                       :: 144
            rRNAs                             :: 11, 11, 11 (5S, 16S, 23S)
            complete rRNAs                    :: 11, 11, 11 (5S, 16S, 23S)
            tRNAs                             :: 106
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 75
            CDSs (without protein)            :: 75
            Pseudo Genes (ambiguous residues) :: 0 of 75
            Pseudo Genes (frameshifted)       :: 21 of 75
            Pseudo Genes (incomplete)         :: 62 of 75
            Pseudo Genes (internal stop)      :: 12 of 75
            Pseudo Genes (multiple problems)  :: 18 of 75
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:00:46
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 139133
            Orig. end                         :: 163050
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP095462.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23917
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..23917
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23917
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13917](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13917
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(408..423)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 24.07"
                     /tool="antismash"
     gene            688..2241
                     /locus_tag="MUG87_RS00715"
                     /old_locus_tag="MUG87_00715"
     CDS             688..2241
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016130937.1"
                     /locus_tag="MUG87_RS00715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUG87_00715"
                     /product="lipopolysaccharide biosynthesis protein"
                     /protein_id="WP_247084611.1"
                     /sec_met_domain="Polysacc_synt (E-value: 3.8e-11, bitscore:
                     40.8, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIKHSLINISTGLVNQIIITSLSFISRTVFIYTLGVEYLGINGL
                     LTNILAMLSLAEAGIGASIMYSLYKPVADNNQEKISVLMHLYKRAYVVIALVVLLLGLA
                     LLPFLNYFIKDSKVEHVHVIYLIFLFNTVAPYFYLHKNSFLNVCQKGYIVTITYSVSAI
                     LSTGMKIGILHFTKNYILYLAIDSIITVATSIILARLVNKRYPFLKKKVTGTLDEDTKT
                     NIIKNIKAIVLQNVGNYLIVGTDNIIISSFVSVAAVGLYSNYYMLIEICRNFTYQIFNN
                     MYHSIGNLVAKESIEKVYNIYNVYLLLNFWLYSFFSILLCIILDPFITLWIGSKFLLSK
                     GIVIVLMLSFYERGMRNAITTIKTTAGVFYADRYGPLIQAVINLAVSIILVKEIGLIGV
                     FMGTLISALVVPFWLTPYLVYKHVFRMSVTLHFIKYTFYGIIGSIAFILTGWSSTFIEV
                     GGWGGLTLRIIVCICIPNTLYFIIFRNTKEFQYLQGIIIGILGTTLKKIKNRGIVKPGM
                     "
     gene            2429..4828
                     /locus_tag="MUG87_RS00720"
                     /old_locus_tag="MUG87_00720"
     CDS             2429..4828
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002160852.1"
                     /locus_tag="MUG87_RS00720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUG87_00720"
                     /product="right-handed parallel beta-helix
                     repeat-containing protein"
                     /protein_id="WP_247084613.1"
                     /transl_table=11
                     /translation="MANLEDLGNVDLITSSPVNGDVLTYDSAKAKWVAEKPFVSNFGGY
                     QPYIIELDRWNIKNNGTQSASTTKGINDAIIWAKLQGYTHVKLQAGTYSIKLNDTTFSG
                     IVMPSNMHFEMEEGCILQLEANSAPKYRVFDVKGIKHAKISGGTVIGDKKSHIYELGVK
                     FMRGGVNTDGTLNNNPNFIRSEVIDRYVSPGILRAFRLWSIPGIASKNYSFFQYKDIIA
                     ATTLVGARTNGQFAPSAPTGRGWFAPIEAANKMIFTIDITSSPLTDAQIAQINAKVDSE
                     NYTHEWGQGIEILGSSYIEVEGVNISNCTGDAISTGWLEYKLNPAEYTQEQMGAHVYIH
                     NCELHHCRRQGISLCSANDVYVFNNKIHSIGKADDGVTVDGIAPMFGIDIESMWSESNI
                     PTWRPELNRQGFELNTRIYIYNNYIFNNARGHFVNADGIHVVIENNIFEGSNVGGVSSY
                     QNNWYVKYINNTFIGCEFTIKGDNFVNGAICNKANIKMQDVRGAVVQNCQIQNGVFYGS
                     SVYGYFGTPTVNVATSTFSYSTPHGMGNGAKICFEQWIGKVPAGISVDKLYYTVNITST
                     SFQVSETLGGTPVSISDAGQAGFNISRFDYGRCYISDVTVERDWRNDNAVAVGFGLLLT
                     GGVIRNINVKNYDIDIKPPANYAGRPITVEGLTVMEGAANIECSNISDCKFIRAKSSRM
                     GGDIALGSTSPQYTRRVQVQGALFQNVGVNFEGNVVTTNSTFLNANIGKSDTAAVAIIA
                     QCYLESTRINLRWLTKEKTVTFANCVFNNITSNVSASTRFIANTTL"
     gene            4902..5141
                     /locus_tag="MUG87_RS19640"
     CDS             4902..5141
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013672.4"
                     /locus_tag="MUG87_RS19640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_368042551.1"
                     /transl_table=11
                     /translation="MLRGEIEESGNYKLCVERNVEKLLYLLGKTQQKGTFFVLEWIVKQ
                     LPLLIKRIHEHGYEIASHGYAHELVYLQKPHIFQ"
     gene            5349..5606
                     /locus_tag="MUG87_RS19645"
     CDS             5349..5606
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023385.4"
                     /locus_tag="MUG87_RS19645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3473 domain-containing protein"
                     /protein_id="WP_368042578.1"
                     /transl_table=11
                     /translation="MRNQFYEFMLPFRRIGPYTIPLGGGGYFRLYPYFIYKRMLCHISQ
                     TPFVFYIHPYELDVSQPHYWRTNVMENVRMYYGVRSTYQK"
     misc_feature    5643..5653
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    complement(5837..5851)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.7"
                     /tool="antismash"
     gene            5990..6295
                     /locus_tag="MUG87_RS19650"
     CDS             5990..6295
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019846.4"
                     /locus_tag="MUG87_RS19650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_368042579.1"
                     /transl_table=11
                     /translation="MWFGATIHNLTSLGTETIYSIDKNQDYIEFVRSNYPHVITYCMDA
                     HILPLDSNAVDYVICRVALQYLHIKQVLKEIYRALDKGGKFFWSCSWLKIYIRLSV"
     gene            6526..7122
                     /locus_tag="MUG87_RS00725"
                     /old_locus_tag="MUG87_00725"
     CDS             6526..7122
                     /EC_number="2.7.8.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146: sugar transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018708371.1"
                     /locus_tag="MUG87_RS00725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUG87_00725"
                     /product="sugar transferase"
                     /protein_id="WP_247084615.1"
                     /sec_met_domain="Bac_transf (E-value: 1.3e-67, bitscore:
                     224.6, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRCLDITVAIIGLLLGSIVIGVVALLVRTKLGSPIIFKQERPGL
                     HGKPFYVYKFRTMTDKRDSAGNLLPDAVRLTSFGQFLRKYSLDELPQLYNVLKGDISLV
                     GPRPLLMEYMELYTDRQAHRHDVRPGITGWAQVNGRNAISWEEKFELDVWYVENQSIWL
                     DLKILFLTAKKVVRSEGISQVGHVTTERFTGTKGM"
     gene            7130..7771
                     /locus_tag="MUG87_RS00730"
                     /old_locus_tag="MUG87_00730"
     CDS             7130..7771
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019383210.1"
                     /locus_tag="MUG87_RS00730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUG87_00730"
                     /product="acetyltransferase"
                     /protein_id="WP_247084617.1"
                     /transl_table=11
                     /translation="MKLVLIGAGGHSKVIRDVAHNAEHTIVACLDDRYKDLYFTSGMYF
                     GPIAAVQAVLLVHPDAKLVIAIGDNGMRKTIMQKLMLPSSSYATIVHQKAVISPSAKIG
                     HGTVIMPGAVINADAVVGEHTIINTRVVIEHDNVVEDFAHISPGAVLAGGVCIKQGVHI
                     GANATVLPNVLVGEWTTIGAGAVVVTNMPSYVIAVGVPATVIKTKMVGGI"
     gene            7774..8934
                     /locus_tag="MUG87_RS00735"
                     /old_locus_tag="MUG87_00735"
     CDS             7774..8934
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (40-167). E-value:
                     5.7e-12. Score: 37.3. Matches aSDomain:
                     nrpspksdomains_MUG87_RS00735_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002199625.1"
                     /locus_tag="MUG87_RS00735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUG87_00735"
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_247084619.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.2e-99,
                     bitscore: 331.8, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 3.6e-10, bitscore:
                     37.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKEETKRIYLSAPHMSGNEQKYIQEAFETNWIAPLGPNVDKFEK
                     AIAETVGVNGAAAVSSGTAAIHLALQLLGVQQGDTVFCSTLTFVASANPILYMNAEPVF
                     IDSEPDTWNMSPKALSRALQEAKGNGKTPKAVIVVNLYGQSAKMDEIMQLCNQYGVPVI
                     EDAAESLGSYYKGKASGTFGAFGVYSFNGNKIITTSGGGMLISSNREAIEKARFLATQA
                     RDEAVHYQHSQIGYNYRMSNILAGIGRAQLEVLDERVEKKRAIFDMYQSALAHIKGVAF
                     MPELEETYSNRWLTVMTVEKEQTGVLASEIIVYLNRENIEARPVWKPLHMQPLFQGCTY
                     YKHEENRSVSETLFHSGICLPSGTGMSYEEQQRVIACLLHVLAIPV"
     aSDomain        7894..8274
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MUG87_RS00735_Aminotran_1_2.1"
                     /evalue="5.70E-12"
                     /label="MUG87_RS00735_Aminotran_1_2.1"
                     /locus_tag="MUG87_RS00735"
                     /protein_end="167"
                     /protein_start="40"
                     /score="37.3"
                     /tool="antismash"
                     /translation="DKFEKAIAETVGVNGAAAVSSGTAAIHLALQLLGVQQGDTVFCST
                     LTFVASANPILYMNAEPVFIDSEPDTWNMSPKALSRALQEAKGNGKTPKAVIVVNLYGQ
                     SAKMDEIMQLCNQYGVPVIEDAA"
     gene            9287..9643
                     /locus_tag="MUG87_RS00740"
                     /old_locus_tag="MUG87_00740"
     CDS             9287..9643
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007085030.1"
                     /locus_tag="MUG87_RS00740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUG87_00740"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_247084621.1"
                     /transl_table=11
                     /translation="MIGKNIRRLREQKGLTLSDLAEQAGVSKSYLSGMERDLKQNPSIH
                     IIEKICDVLDVTLETILETKSMYGNAQQLENEWLELIEELREISVDKEQLLEYKTLMRY
                     IKWKAEKNIDKVHS"
     gene            10001..11935
                     /locus_tag="MUG87_RS00745"
                     /old_locus_tag="MUG87_00745"
     CDS             10001..11935
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020061970.1"
                     /locus_tag="MUG87_RS00745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUG87_00745"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_247084623.1"
                     /sec_met_domain="GATase_7 (E-value: 9.4e-18, bitscore:
                     62.1, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 1.4e-22, bitscore:
                     78.6, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAIAGIYQTTNEPVAIDNCKRMMSSLQCYPADQVDVWVQNHIFL
                     GCHAQWITPESRGERLPYYDYRRKLAITADAIIDNRQELFDRIGVSYERRKLMSDSELI
                     LLAYEKWGEELPAYLIGDFAFMIWNEKTQELFGARDFSGGRTLYFHHDEKRFSFCTVIE
                     PLFSLPYIEKKLNEQWLAEFLAIVGMVDVADSFITPYLGIQQVPPSHSIKVKNGKVSFS
                     RYCTLERNTSIKFKSNEEYIEAFRDIFQEAVNSRMRTYKEVSAQLSGGLDSGSIVGFAA
                     KGLRAQNKQLHAFSYIPTSDFPDFTPHYLMPNEQEYMKETVQFVGNIKDHYLDFKGRDS
                     YTEIDAFLTAMEMPYKFFENSFWMKGMFEQASIHGAGVLLNGGRGNLSISWGSATDYYA
                     LLLKRLRWLRLYRELDQYSKRTGGMRLRRIPYIARQAFPVLERHNAVEAAQPGLIHPEF
                     AHRTRVYEKLQGYGMNSSGWFSMSDPFEQRNSHFKELFHWNASNTISTKLSLQFGVWKR
                     DPSNDLRVIRFCLSIPEEQYVQDGLDRALIRRAAEDILPDKVRLNQHIYGVQGADWVYR
                     MTPHWERFMDEVREMKKDIDLLAFVNPEALRLGLDIAKQGPKAEHAIDFNHKNLMRSVI
                     TYRFLKQFS"
     gene            11950..12105
                     /locus_tag="MUG87_RS00750"
                     /old_locus_tag="MUG87_00750"
     CDS             11950..12105
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002160858.1"
                     /locus_tag="MUG87_RS00750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUG87_00750"
                     /product="paeninodin family lasso peptide"
                     /protein_id="WP_247084625.1"
                     /transl_table=11
                     /translation="MKKVWQQPTLEVLDVNMTMASTVYGPYTDEAYVPGKPVDPNNPGT
                     WKRFTS"
     misc_feature    complement(12197..12213)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 22.07"
                     /tool="antismash"
     gene            12245..13165
                     /locus_tag="MUG87_RS00755"
                     /old_locus_tag="MUG87_00755"
     CDS             12245..13165
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002160859.1"
                     /locus_tag="MUG87_RS00755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUG87_00755"
                     /product="aldolase"
                     /protein_id="WP_247084627.1"
                     /transl_table=11
                     /translation="MITAQQTFSYKAFGFVITSEIALPELVTANSATPDISVIIEDSKV
                     DSMLIETPYYHFVEHNTVRFYIPDVGSFLVAAGQKIMISPVEDADEGLLRLYVLGTCMG
                     AILMQRRILPLHGSAVVIEGKAYAFIGESGAGKSTLASTLLQRGYQLLSDDVIAISLLG
                     NVPFVTPSYPQQKLWQDSLRSLKMDSKQYTSIYGREDKYSVPVSSYVLDQVPLAGIFEL
                     DKIDNEEIHFRAMNTLEGLQLLSSHTYRNFLLPRLGLMEWHFQMSASIVNKIDVYQLHR
                     PTSRFCAEELVAIIINAVKKEYEEV"
     gene            13162..13449
                     /locus_tag="MUG87_RS00760"
                     /old_locus_tag="MUG87_00760"
     CDS             13162..13449
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002128586.1"
                     /locus_tag="MUG87_RS00760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUG87_00760"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_247084629.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 3.5e-26,
                     bitscore: 88.9, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.2e-16, bitscore: 57.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQTLNIQQTVVQVQGNLVSDMGGEKVMLSIENGKYYNLGEMGGV
                     IWDLLVEPICIAELVEKLVREYDVERNICEAHVISFLSMLEQENLVKLVG"
     aSDomain        13192..13437
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_MUG87_RS00760_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="2.60E-28"
                     /identifier="RREFam002.1"
                     /label="MUG87_RS00760"
                     /locus_tag="MUG87_RS00760"
                     /protein_end="92"
                     /protein_start="10"
                     /score="88.9"
                     /tool="antismash"
                     /translation="VVQVQGNLVSDMGGEKVMLSIENGKYYNLGEMGGVIWDLLVEPIC
                     IAELVEKLVREYDVERNICEAHVISFLSMLEQENLVK"
     gene            13465..13917
                     /locus_tag="MUG87_RS00765"
                     /old_locus_tag="MUG87_00765"
     CDS             13465..13917
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002160861.1"
                     /locus_tag="MUG87_RS00765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUG87_00765"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_247084631.1"
                     /sec_met_domain="PF13471 (E-value: 8.8e-24, bitscore: 81.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFYKKLKTLCSLHPKTCLLLGEAFVYLAWARILKALPFAKVVPL
                     LGEQMNETSTDASHTNLIILQDISDAVHAMSLHTYWESMCLVRAIAAMKMLERRGIEST
                     LYLGTARDENGQMIAHAWLRSGPFYITGAEEMHRFSVVGKFARKLG"
     gene            13936..15093
                     /locus_tag="MUG87_RS00770"
                     /old_locus_tag="MUG87_00770"
     CDS             13936..15093
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002111220.1"
                     /locus_tag="MUG87_RS00770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUG87_00770"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_247084633.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 5.5e-64, bitscore:
                     213.9, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQVGYTLNLNCVPTELRLLLILLQDEGNVDEINLQHINWNTFLEL
                     AMHHRVFPMLYRRLQKLNLPIDASILQALHQDFKNNTFQMLHLSAEMQYMSRLLADRGI
                     RSLFLKGPILAMELYRDLSLRTSCDLDVLVPLADLQRVEELLIEQGYEKDDYIETVLGD
                     WKWRHHHVTYFHPVKGIKFEVHWRLNPGPAIEPRFQDLWQRRRTRRFGNEDVAFLGQED
                     LFFFLVAHGARHGWSRLRWLLDIHQFVKQDVDWKKVSRTLQAHGYLRVGGQALILGSSL
                     LKTSLSTNMVTLLKGKHPERLAQEAVFYLESMINLHTEPLPHDVSVYHKKHLVSLMSPM
                     QKTMFLISFLYPYPEDAKTLPLPKSLHFLYFPLRPAIWAWKKIVR"
     gene            15110..16936
                     /locus_tag="MUG87_RS00775"
                     /old_locus_tag="MUG87_00775"
     CDS             15110..16936
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016096316.1"
                     /locus_tag="MUG87_RS00775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUG87_00775"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_247084635.1"
                     /transl_table=11
                     /translation="MKELRYYMRELHMFSGKVLYINMIAMVLISLLEGAGILLLIPMIQ
                     ASGIVGEMAGASWLENFFAFVNKVPETWALPVVLLIYVILILFQTIIQQKLNVRNMQIL
                     IKFTNSIRLKIYRSLLEVEWSFFVKKRKSDLINLLTSEFGRFVNGINLCLQLLTSFLFT
                     CIQIGIAFCLSPSITLFVLVSGLLLSYFSRRFIKRSQSLGSKSTDIAKDYLSGITDHFN
                     GVKDIKSNALECSRYTWLQTWCETVQKEQLAYARLSNSSQLFYKVVSTILVALLIYVSI
                     QMFQSQPAQLLLIVLIFSRLWPRFTGLQSNLEQVGATIPVFQSLFQLQQQCEKLRELNL
                     ANQEEVVPLQIQEGLTCKNLSFQYKNEGNTYALQNINLHIPVNSMTAIAGRSGAGKSTL
                     IDLIMGLMQPDVGNVYVDSKPLTQQELPALRKEMSYVAQDPFLFNASIRENLLIVRPDA
                     TEKELWDALEFASAVFVKQLQQGLDTVIGDRGVRLSGGERQRLVLARAILRKPTILVLD
                     EATSALDTENERHIQQALERLKGQMTIIVIAHRLSTIANADQVVVIDKGEVVQAGSFTD
                     LAKNDKGLFHKLLGNQVTLPTEQKVAGVLQYR"
     gene            17053..17373
                     /locus_tag="MUG87_RS00780"
                     /old_locus_tag="MUG87_00780"
     CDS             17053..17373
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MUG87_RS00780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MUG87_00780"
                     /product="hypothetical protein"
                     /protein_id="WP_247084637.1"
                     /transl_table=11
                     /translation="MKVVKKMLVLFMFISAFTFPTSALASGYNYQQKNTYQTYVYQVKT
                     YYDTSKQTNYYSSSKGNSHYTYRYDCYDDYKDSIDIWRDWYCNWDWEWFCKWYEWLWGK
                     KK"
     gene            17476..17715
                     /locus_tag="MUG87_RS00785"
                     /old_locus_tag="MUG87_00785"
     CDS             17476..17715
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MUG87_RS00785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MUG87_00785"
                     /product="hypothetical protein"
                     /protein_id="WP_247084639.1"
                     /transl_table=11
                     /translation="MKHQTSRLLYVGIFMLCCWGILGLVVKQTSHVSVMEQVPIAVDTL
                     APAVAHTPVLSTNAYQVMRLKGQVRATLHVLFYM"
     gene            17811..18167
                     /locus_tag="MUG87_RS00790"
                     /old_locus_tag="MUG87_00790"
     CDS             17811..18167
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012376.4"
                     /locus_tag="MUG87_RS00790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUG87_00790"
                     /product="hypothetical protein"
                     /protein_id="WP_368042580.1"
                     /transl_table=11
                     /translation="MSKSYYGGTYKNNRGHYDLISVGGNDDIMVYLGWSMDADGIAWIS
                     EVLAAHPDRKAILHFHEYMLATGTRHPLGEKLYQEIMLKHPNVFAVLSGHYHESQQLID
                     EIDDDGDGKADRKV"
     gene            18222..18719
                     /locus_tag="MUG87_RS00795"
                     /old_locus_tag="MUG87_00795"
     CDS             18222..18719
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MUG87_RS00795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MUG87_00795"
                     /product="hypothetical protein"
                     /protein_id="WP_247084643.1"
                     /transl_table=11
                     /translation="MLHFDTIRNRIIVNTYSPYLNDYNFYDTNVYPAKDEFVMNLDLTP
                     QKKQVATDYFAVNVYTDNVIGKVERVNSGGIARATWNNLKSNAWYAIVTDTFTGQARSD
                     IQTYVKDRTVHSITKKSHTQANSIYEKGNAMWLHVTLFSFWILCSVMVILAGAIFYQMR
                     KR"
     gene            18784..19761
                     /locus_tag="MUG87_RS00800"
                     /old_locus_tag="MUG87_00800"
     CDS             18784..19761
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013775.4"
                     /locus_tag="MUG87_RS00800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUG87_00800"
                     /product="phosphotransferase enzyme family protein"
                     /protein_id="WP_247084645.1"
                     /sec_met_domain="APH (E-value: 2.4e-20, bitscore: 71.3,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEAFIYDLFNEDLLFTAAERFQIERNSLEKVSTSESFIYSCICQG
                     QEMILRITHSSHRSAIEIEGEMEWIAHLISQGVPASRPVLSVHSNVIEEIPTKEGQFFV
                     TVFEKAPGRHPNIHDWKRDFFIEWGRTTGAMHKAAVLFDYTTKRPMWQNEYNITAIHTY
                     GEPDLIEVQRQLIRDLEALPKDESVYGIIHSDFEDGNFFIHHGTIHPFDFDECQYHWFA
                     YDIGNAVRAASWFVADTDSVYTVEEFLNDFLEGYYSEYHLDFHWIEKLPIFIRLRDLCI
                     YVYLIGKRGHNMSEGEKRFLASMKEEIRAKKPCVQIDVSQIRRY"
     gene            19982..20962
                     /locus_tag="MUG87_RS00805"
                     /old_locus_tag="MUG87_00805"
     CDS             19982..20962
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009794162.1"
                     /locus_tag="MUG87_RS00805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUG87_00805"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_247084647.1"
                     /transl_table=11
                     /translation="MNIKISVLDLAPIVQGGTATDSFRNTLDLAQHAEKWGYNRYWLAE
                     HHNMAGVASSATSVVIGYVAGGTSRIRVGSGGIMLPNHAPLVIAEQFGTLASMYPGRID
                     LGLGRAPGTDQLTARALRRDLRNADDFPEQLEELRAYFAGDVENVRAVPGEGLDVPIWL
                     LGSSGFSARLAGQLGLPFAFASHFSPDYTLPAIEAYRSTFTPSPVLDKPYVMVGANVIV
                     AETDEKARYLATSQQQQFLNLIRGRTAPLQPPVENMDYLWSEYEKAALERQFGSAIVGS
                     RETVKAKLEDFVNMTGADEVIASAHIFHHDDRLHSYEMLAEIVSR"
     gene            21033..21161
                     /locus_tag="MUG87_RS19575"
     CDS             21033..21161
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MUG87_RS19575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_281503668.1"
                     /transl_table=11
                     /translation="MKVRYKLILLALLALAVIRVFDWFGVSPDDFPAEYKMPQKQE"
     gene            21187..>21769
                     /locus_tag="MUG87_RS00810"
                     /old_locus_tag="MUG87_00810"
                     /pseudo=""
     CDS             21187..>21769
                     /GO_function="GO:0008721 - D-serine ammonia-lyase activity
                     [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0046416 - D-amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000658548.1"
                     /locus_tag="MUG87_RS00810"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="MUG87_00810"
                     /product="D-serine ammonia-lyase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTAELLARIKETEEVQWRNPYLLLFATAIHNARITAENVKAVEER
                     LRRFEPYIAKVFPQTNGVIESPLIAIPTMQKHLQVKGKLLLKCDSHFTNFRVD"
     misc_feature    complement(21975..21988)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 23.47"
                     /tool="antismash"
     misc_feature    22213..22225
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.27"
                     /tool="antismash"
     misc_feature    22510..22524
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.17"
                     /tool="antismash"
ORIGIN
        1 aaaacggtgg aaagcatcga gcaattaata aggcaataga tttagcaaat ggagatgtat
       61 tctttatagt ggactcagat gattatttaa taccaaccgc actcgaaaaa gtagcaagtt
      121 ggttccgtac tattgaaaat caagttggct tttgcggcgt ttctgggaat agaggccgta
      181 ccgagataga tgttatcggt actactttta aaggggatta tatagatgca acttcattag
      241 aacgaaatca gtttcatatt acgggagata aagcagaagt gttttatact catgtcttaa
      301 agaaatataa gtttcctgaa tatgaaggag aacgttttat tagtgaagcg acagtatggg
      361 agaaaatggc ctacgaagga tataaaatac gttggtttaa cgaaacgatt tacatatgta
      421 attatcttga ggatggttta acacaaaaca tgattcaaac atttgcgaaa agcccaagag
      481 ggacggcact gtatatgaag caacaaataa aatttcataa ctgtggcttg aaaggaaaaa
      541 tggcatatta caatctatat tatagcttcg ttaaatccca attaaatctt aaggaggccg
      601 cagcacacat ggaaacatct ttgtttacta tgatagccag tgtgattttg gctgagacaa
      661 agaaaaggtt aaccggatgg cgtttctatg cgaattaaac attctcttat caatatttcg
      721 actggtcttg taaatcaaat tattatcact tcgttaagtt ttatctcgag aactgtgttt
      781 atttacactt taggagtaga atacttaggt atcaacggcc ttttaactaa tatattagcg
      841 atgctttctc ttgctgaagc cggcattggg gcgagtatta tgtatagttt atataaaccg
      901 gtagccgaca acaatcaaga aaagattagt gtgctcatgc atctttataa aagagcatat
      961 gtagtaatcg ctttggttgt gcttttactt ggtttagcat tgttaccttt tctcaattat
     1021 tttataaaag attctaaggt ggaacatgta catgtaattt atcttatttt cttatttaac
     1081 acagtagcac cttattttta tttacacaaa aattcatttt taaatgtttg tcagaaggga
     1141 tatattgtta caataacgta ttccgtctca gcaattcttt ctacagggat gaaaattggc
     1201 attttacact ttacaaagaa ttatatttta tatttagcaa ttgatagcat catcactgtg
     1261 gctacaagta ttattctagc gaggcttgtc aacaagcgat atcctttttt aaaaaagaag
     1321 gttacaggaa cgctagatga ggacacaaaa acaaatatta ttaaaaatat aaaagccatc
     1381 gtgctacaaa atgtaggaaa ctatttaatt gtaggcacag acaatattat tatttcatct
     1441 tttgtcagcg ttgcagctgt aggtttgtat tctaattatt atatgctaat tgaaatctgt
     1501 cgtaatttta cttatcaaat ttttaataac atgtatcata gtatcggtaa tttagttgca
     1561 aaagaaagta tcgagaaagt ttacaatata tataatgtat atttattgtt aaacttttgg
     1621 ctgtattctt ttttttccat tttattatgt atcattcttg atccgtttat tacgttatgg
     1681 attggttcca aatttttgct gagtaaaggt atagtaattg tattaatgct ttcgttttac
     1741 gaaagaggga tgagaaatgc tatcacaaca ataaaaacaa ctgctggggt gttttacgcc
     1801 gatcgctatg gacctcttat acaagctgtt atcaacctag ctgtgtccat tatactagta
     1861 aaagaaatag gtttaatagg tgtctttatg gggacgctaa tcagtgcttt agttgtacca
     1921 ttttggttaa caccttatct agtttacaaa catgtgttta ggatgtccgt tactttgcat
     1981 tttataaaat acacattcta tggcattatt ggtagtattg cttttatatt gaccggttgg
     2041 agcagtacct ttatagaggt aggtggatgg gggggcctga ctttacggat tatagtttgc
     2101 atatgtatac ctaatacttt atattttata atctttcgaa ataccaagga atttcaatat
     2161 ttacaaggaa tcataatagg tattttaggt acgactttaa agaaaataaa gaacagagga
     2221 atagtaaaac ctggaatgta gatagaaaat ctcttaataa aaggcgcgca taagccgcct
     2281 tttattagtt ttgatatatg aatctatact atatatatta ttttaataag atatatataa
     2341 tttacgtgaa gttaaagtat aaaacccaaa ctattttcta tttataatca taatatatag
     2401 aaataataga agggtgtggt tatacagaat ggctaatctt gaagatttgg gtaatgtcga
     2461 tttgattaca agttctccag ttaatggaga tgtattaact tatgatagtg ctaaagcaaa
     2521 atgggtagca gagaagcctt ttgtttcaaa ttttggtggc tatcagcctt atatcattga
     2581 acttgatcgt tggaatatta aaaataacgg cacacagtct gcttcaacaa caaaagggat
     2641 taatgatgca attatatggg ctaagttaca aggatacaca catgtgaagt tacaggcagg
     2701 gacatacagt attaaattaa acgatacaac attttctggc attgtaatgc caagtaacat
     2761 gcattttgaa atggaagaag gttgtatttt acagttagag gccaactcag cacctaaata
     2821 tcgtgtattt gatgtaaaag gaattaagca tgcaaagatt tctggcggga ctgttattgg
     2881 tgataaaaag tcacatatat atgaacttgg tgtaaagttt atgcgtggtg gtgtaaatac
     2941 agatggtacg ttgaataaca atcctaactt cattcgtagc gaagtcattg atcggtatgt
     3001 atccccagga attcttcgtg catttcgatt gtggtctatt ccaggaattg cttctaagaa
     3061 ttatagtttt tttcaataca aagatataat tgcggctaca acgcttgttg gagcacgaac
     3121 aaacggacaa tttgctccta gtgccccaac gggaagaggc tggtttgccc ctattgaagc
     3181 agcaaataaa atgattttta caattgatat tacatcttct ccattaacag acgcacaaat
     3241 tgcacaaatc aatgcgaaag tagatagtga aaattacaca catgaatggg gacaaggtat
     3301 cgagatacta ggatcaagtt atattgaggt tgaaggagtc aatatcagta attgtacagg
     3361 cgatgcaatc tcaacaggat ggttggaata caaattaaat cctgcagaat acacgcaaga
     3421 gcagatgggg gcacatgtat atattcataa ttgcgagttg catcattgcc gtcgtcaagg
     3481 gatatcacta tgtagtgcta atgatgtata tgtattcaat aataagattc attctatcgg
     3541 taaagctgat gatggtgtta ctgttgatgg gattgcacca atgtttggta ttgatatcga
     3601 atcaatgtgg tcagaaagta atattcccac ttggagacca gaattgaata gacaaggatt
     3661 tgaattaaat actagaattt acatttataa taattatata tttaataatg cacgcggaca
     3721 ttttgttaat gcagatggta ttcatgttgt gattgaaaac aacatatttg aaggttctaa
     3781 cgtaggtggc gtcagctcat atcaaaacaa ctggtatgtt aagtatatta ataacacatt
     3841 tataggttgt gagtttacga taaaaggtga taatttcgta aacggtgcaa tttgtaataa
     3901 agcaaatatc aaaatgcagg atgtacgtgg tgctgtagtt caaaattgcc aaatccaaaa
     3961 tggtgtattt tatggatcta gtgtatatgg ttatttcgga acgcctacag taaacgtggc
     4021 gacaagcacc tttagctata gcacaccgca tgggatggga aatggagcaa aaatttgttt
     4081 cgaacagtgg attggtaagg tacctgcagg gattagtgtg gataaacttt attatacagt
     4141 caacataaca tctacaagct ttcaggtttc tgagacgctc ggaggtacac cagtgagcat
     4201 tagtgatgct ggtcaagcgg gatttaatat tagccgtttt gattatggtc gttgctatat
     4261 ctcagatgtt actgtggaaa gagattggag aaatgataac gcagtagccg tcggatttgg
     4321 tttgttgtta acgggtgggg ttattagaaa cattaacgtc aaaaactacg atatagatat
     4381 taagccccct gcgaattatg caggacggcc aataacagta gaaggtctta ctgttatgga
     4441 aggtgctgcg aatatagaat gcagtaatat aagcgattgt aagtttataa gagctaaatc
     4501 gagtcgaatg ggtggagata tcgcactagg ctctacaagt ccacaataca ctagacgtgt
     4561 tcaagtacaa ggtgccttgt ttcaaaacgt tggtgtcaac tttgaaggaa atgttgtcac
     4621 tactaacagc acatttttaa atgctaatat tggtaaaagt gatactgctg cagttgcaat
     4681 tattgcacag tgttacttag aaagtactag aatcaactta cgttggctga caaaagaaaa
     4741 aacggtaact tttgcgaatt gtgttttcaa taatattact tccaatgtta gcgcgagtac
     4801 aagattcatt gccaatacca cattataaac agaaaaccgt cacatttgtg acggttttct
     4861 gtttataatg ttttgtataa gtatatagga atgatcagat attgttaagg ggggagatag
     4921 aagaatcggg aaattataag ctatgcgtag aaagaaatgt agaaaagctg ctatacctat
     4981 taggtaaaac gcaacagaaa ggtacttttt ttgtactcga atggatagta aagcaacttc
     5041 ctttactcat taagcgtatt catgaacatg ggtatgaaat tgcgtctcat ggttatgcgc
     5101 atgagctggt ttatcttcaa aagcctcata tatttcagta agatgttaga aaaacaaaga
     5161 tagtgctgga agacttgatt ggcgaacgga tattaggtta ccgggctcca tgtttttcaa
     5221 atacaccatg ggctattgat attttacagc aagaaggata catgtatgat tcaagtattg
     5281 tacttaatac atggagacaa acatattaac cagaaacgca tataataagc aataatcatt
     5341 ttatagagat acggaatcaa ttctatgaat ttatgttacc ctttagaagg ataggtccct
     5401 atactattcc tttaggtggt gggggatatt ttcgattata tccgtatttt atatacaagc
     5461 gaatgctttg tcatattagt caaacacctt ttgtctttta catccatccg tatgaattag
     5521 atgtgagtca gccacattat tggagaacaa atgttatgga gaatgtaaga atgtactatg
     5581 gtgtgcgtag tacctatcaa aagtagaaca tcttctctct gcatttccgt ttactactat
     5641 gatgcattgt cacaaaaaag taggaaagtt caataacttc caaagttttc gttacgacta
     5701 tgaaggagat attaatgagc ttatatcaat atattttaac caatcataca ttattgaggg
     5761 gtgtaacata ctattaaata ggtgtacatt atcagtcttt aagcgtaccg tcatcagaaa
     5821 cagcgaaaac attacaaatt ttgagaatat tatcatcaga tatggttgtt cttcatagag
     5881 aattagggta tgcttgctat gagcactatc gacaatgtta cgaagaaaac gtatttgatc
     5941 aactgcttat aaaagaagga ataggtaaac ggcgaatatt agatctttgt tgtggttcgg
     6001 tgctaccatt cataacttaa cctctttagg aacggaaaca atttactcta tagataagaa
     6061 ccaagattat atagagtttg ttcgcagtaa ttatcctcat gttataacgt attgtatgga
     6121 tgcccatatt ttacctttag atagtaatgc agttgattat gttatatgtc gtgttgcgtt
     6181 acaatatcta catataaaac aagttttaaa agagatttat cgtgctttag ataaaggtgg
     6241 taagtttttt tggagttgtt catggctcaa gatatatatt agattatctg tttaatagaa
     6301 aaattttgtt tcactcacaa acatggtacg ctttattacc aggaaaaaag caacctattc
     6361 aacaaggttc attcttaata gagaataata ttgtgaagat aatgaaagaa attggttttt
     6421 taaaggttag catatgtaag gatacacagc agtgtatggt tggtattttc ccagtatatt
     6481 ttgctgttat agcagagaaa taagaacaag agaaggtgta tatatatgaa aagatgtcta
     6541 gacatcaccg ttgcaattat tggcttgttg ctaggttcta ttgtcattgg cgttgttgcc
     6601 ttactcgttc gaacaaagtt aggttcccca attatattta aacaagagcg acctggcctg
     6661 cacggtaaac cattctatgt ttacaagttt cggaccatga cagataaacg agacagtgca
     6721 ggaaacctgc ttcctgatgc tgtaaggtta acttcattcg gccaattcct caggaaatat
     6781 agtttagatg aactgccaca actctacaac gttttaaagg gtgacattag cttagtagga
     6841 ccacgacctt tattaatgga gtatatggaa ctttacacag acaggcaagc tcatcgccat
     6901 gacgttcgtc ctggtattac agggtgggca caagtgaatg gaagaaatgc gatatcatgg
     6961 gaagaaaaat tcgaacttga tgtttggtat gtcgagaatc aatctatctg gctagatctt
     7021 aaaattttat ttcttacagc gaaaaaggtt gtaagatcag aaggtattag ccaggttgga
     7081 catgtaacaa cagaacgctt tacaggaacg aagggaatgt gagagagaga tgaaattggt
     7141 actaattggg gctggggggc atagcaaggt aattcgagat gttgcacata atgcagagca
     7201 tacgattgtt gcttgcctag atgatcgtta caaagattta tactttacaa gcggtatgta
     7261 ctttggacca attgcagctg ttcaagcagt actattggtt catccagacg caaagctagt
     7321 tattgcaatt ggagataatg gaatgagaaa aacaattatg caaaagttaa tgctaccaag
     7381 cagttcgtac gcaactattg tgcatcaaaa agctgtaatc agtccaagtg caaagattgg
     7441 acatggtaca gttattatgc cgggtgctgt tattaatgcg gatgcagtgg taggtgaaca
     7501 taccattatt aatacaaggg ttgtcattga acatgacaac gttgttgaag attttgctca
     7561 tatttctccc ggagcagtgc tcgcaggtgg tgtatgtatt aaacagggcg tacatattgg
     7621 tgctaacgca acggttttac caaatgtgtt ggtaggagaa tggacaacga ttggtgctgg
     7681 cgctgttgta gtgaccaaca tgccttctta tgtaattgca gtaggtgtgc cggccactgt
     7741 tataaaaacg aaaatggttg ggggtatcta aaaatgttga aagaagaaac aaaaagaata
     7801 tatctatctg cccctcacat gagcggaaat gagcaaaagt atattcaaga agcatttgaa
     7861 accaattgga ttgccccact tgggccaaat gttgataagt ttgaaaaagc aattgccgaa
     7921 acggtgggag taaatggtgc ggctgcagtg agttctggaa cagcagcaat ccatttggcg
     7981 ttgcagctac taggtgttca gcaaggagac actgtctttt gttccacact tacctttgtt
     8041 gccagtgcaa atcccattct atatatgaat gcggaaccgg tgtttattga ttcagaacct
     8101 gatacatgga atatgtcgcc caaggcgctt tctcgtgcct tgcaagaagc taagggaaat
     8161 ggaaagacgc ctaaggctgt cattgttgtg aacttatatg gacagagtgc aaaaatggat
     8221 gaaattatgc agctatgtaa tcaatatggt gtgccagtca ttgaagatgc cgcagagtca
     8281 ttgggttcct attataaggg aaaggcgagc ggtacatttg gagcatttgg tgtctattcc
     8341 ttcaatggca ataagattat tacgacttcc ggcggtggta tgttgatctc cagtaataga
     8401 gaagctattg agaaagctcg gtttttagct acacaagcca gggacgaagc agtgcactat
     8461 caacatagtc aaataggcta caattatcgt atgagtaaca ttctcgccgg aattggaaga
     8521 gcgcagctag aggtactgga tgaacgggtt gagaaaaaac gtgctatttt tgacatgtat
     8581 caatctgcgt tagcccatat caaaggcgtt gcatttatgc cggaactaga agaaacctac
     8641 tccaatcgat ggctcacagt aatgacggtt gagaaagaac aaacaggggt cttagcttct
     8701 gaaatcattg tatatttgaa tagagagaat atagaagcgc gtcctgtatg gaagcctctg
     8761 catatgcagc cgttatttca aggatgtaca tattacaaac atgaagaaaa tagaagtgtt
     8821 tctgaaactt tgtttcattc agggatttgt ttaccatctg gaaccggtat gtcatatgag
     8881 gagcagcagc gagtgattgc atgtctgtta catgtgcttg cgattcctgt ttgataactg
     8941 tgcttgattg agattgcggc acttcatgcg aacaaacatt gtttctttaa taggggagtc
     9001 gttgcaatct cgatataaag caaaataata ggtgtacata tatgtatgat aatagttcaa
     9061 cagttttttt cattaagaaa ccctctcttt ccatagtgca aagaaagaac atcactaatc
     9121 acctatatta agatattctt ttgccttcta atgaacatat gtgtgttctg tctgtttata
     9181 ggatagcatt catctagtaa aacctcattg taataagata atagctaata gtgttaatta
     9241 atagggaaga acaaaatgaa aatgaagggt aggattaggt aacgtcatga ttggaaaaaa
     9301 cattagaaga ctgcgtgagc aaaaaggatt aactctttca gatttggctg agcaagcagg
     9361 cgtttccaaa tcttatttaa gcggaatgga gagggattta aaacaaaatc cttctataca
     9421 tattattgag aagatatgcg atgtacttga cgtaacatta gaaacgatat tagaaacaaa
     9481 aagtatgtac ggaaatgccc agcaacttga aaatgagtgg ttagagttaa tcgaagaatt
     9541 gcgtgaaata tcggtggata aagaacaatt acttgaatac aaaacattaa tgaggtatat
     9601 caaatggaaa gcagaaaaga atatagacaa agttcactct tagaaaaatc ctatgacata
     9661 tgtttactag ttagcaaaag accattatac ttgaaagcgc aaacaataaa tgatatggat
     9721 tagaatacac tactatgatt tttagattgt tgcccttttt tgtcattatc tatcaataca
     9781 tagtatctat gtattgatat caaaaacatt ttatatttct agtatacgga taattgacaa
     9841 gtaattcgca agatgataat ctttaaatat gttctctata aagaactttt atattctttt
     9901 tagtgtaatg aatctgttta aatacgagca gctatgcttg tcgattagat actagagatg
     9961 tcgcgacggt gttaaattta ttgtatatca ggagggtaac atgagtgcga tagcgggcat
    10021 atatcaaact acaaatgaac cagtcgctat agataactgt aagaggatga tgagtagtct
    10081 tcaatgttac cctgctgatc aagtagacgt ttgggtgcaa aatcatatat ttttagggtg
    10141 ccatgcgcag tggattacac ctgaatcaag aggagagcgt ttgccgtatt atgattatag
    10201 gcgcaagcta gctattactg ctgatgctat tattgataat agacaagaat tatttgatcg
    10261 aataggtgta tcttacgaac gtaggaaatt gatgtctgac agtgaattaa ttttattggc
    10321 gtacgaaaag tggggtgaag aattacccgc ttatttaata ggtgactttg cgtttatgat
    10381 ttggaatgaa aaaacgcaag agttgtttgg agcaagagat ttctcaggag gacgaacatt
    10441 atattttcat catgacgaaa aacgattttc gttttgtacc gtcattgagc cgttattcag
    10501 tttaccttac atagaaaaaa aactaaatga acaatggctc gctgaatttt tagcaatcgt
    10561 aggaatggta gatgtagcag actcgtttat tacaccgtat cttggaattc aacaagtacc
    10621 accttcacat agcataaaag ttaaaaatgg aaaagtttca ttctctaggt attgtacgtt
    10681 agagcggaac acatctatta aatttaaatc aaatgaagaa tacatagaag catttagaga
    10741 catattccaa gaagctgtaa attcacgaat gcgcacatat aaagaagtaa gtgcacagtt
    10801 gagcggagga ttggattccg gatccattgt tggattcgca gccaaagggt tgcgtgctca
    10861 aaataaacag ctacatgcct tcagctatat accaacaagt gattttcctg attttacacc
    10921 acattattta atgccaaacg aacaggaata catgaaggaa accgttcaat ttgtgggtaa
    10981 tataaaagat cattatttag actttaaggg aagagattcg tataccgaaa ttgatgcttt
    11041 tttgactgcg atggaaatgc cgtataagtt ctttgagaac tctttttgga tgaaaggaat
    11101 gtttgaacag gctagtattc atggtgcagg tgtattacta aatggtggtc gaggcaatct
    11161 atctatatct tgggggtccg ctaccgatta ctatgcgtta cttttaaaga gattaaggtg
    11221 gctaaggtta tatcgagagt tagaccaata cagtaagcgt acagggggga tgcggttacg
    11281 aagaatacct tacattgctc gccaagcttt tcctgttctt gaaagacaca atgcagtaga
    11341 ggctgcacaa cctggtttaa ttcaccctga attcgcccat cgtacccgtg tttatgagaa
    11401 gttgcaagga tacggtatga attcttcagg atggttttcc atgtcagatc catttgaaca
    11461 gagaaattcg cattttaaag aattgtttca ttggaatgca agtaacacga tctctactaa
    11521 actttcatta caattcggag tgtggaaacg tgatccgagt aatgatcttc gtgtcatacg
    11581 cttctgccta tcaattccag aagagcaata tgtgcaggat ggattagatc gagctcttat
    11641 tcgtagagcg gcagaagata ttcttcctga taaagtacga ctgaatcaac atatatacgg
    11701 tgtacaggga gctgactggg tgtatcgtat gacaccccat tgggagagat ttatggatga
    11761 ggtaagagaa atgaaaaaag atatagatct tttagcattt gtcaatccag aagcacttcg
    11821 gttgggctta gatattgcaa aacagggacc aaaggctgaa catgcgattg actttaacca
    11881 taaaaatctg atgcgcagtg taattactta tcgatttctg aaacagtttt cttgaaaggg
    11941 ggtgagaata tgaaaaaggt atggcaacaa cctacactag aagttttaga tgtaaacatg
    12001 acaatggctt ctacagttta cggtccgtat acagatgagg cttatgtacc aggcaaaccc
    12061 gttgatccaa acaatccagg tacatggaaa aggtttacaa gctgatagta tggtacatag
    12121 aaagactatt gtgccagact gagtttggtc aattacattt attgtagaat gcgtgtcaaa
    12181 aacccttatg ctgtgaatac tgtatagggg ttttttctta aagatagtat tggagtgaag
    12241 gttcatgatt acagctcaac aaactttttc atataaagca tttggttttg ttattacaag
    12301 tgaaatcgct ttaccagaac tagtaacagc aaattctgct acccctgata ttagtgttat
    12361 aattgaagat agtaaggtag attcaatgct aattgaaaca ccctattatc actttgtaga
    12421 gcataataca gtaaggtttt acatccctga tgtagggagt tttcttgtag ctgcaggaca
    12481 gaagattatg atttcccctg ttgaagatgc tgacgaaggg ttattgcgtt tatatgtgtt
    12541 agggacatgc atgggagcta tcttaatgca aagacgcata ttaccacttc atggtagcgc
    12601 agttgtaata gaggggaagg cttacgcttt tattggcgag tctggtgccg gaaaatcgac
    12661 gcttgcctct actttattac agcgaggata ccaactttta agtgacgatg ttatcgctat
    12721 atctctatta ggaaatgtgc cgttcgtcac accttcatat ccacaacaaa aattatggca
    12781 agatagcttg cgaagcttga aaatggattc taagcaatac acatccatat atggtcgaga
    12841 agataagtat agtgtaccag tttcttcata tgttctagat caagtacctt tagcagggat
    12901 ttttgaatta gataaaatag ataatgaaga gatacatttt cgtgcaatga atacgcttga
    12961 aggcctacag cttttatcta gtcatacgta tcgaaacttt ttgcttccgc gtttagggct
    13021 gatggaatgg cattttcaaa tgtctgcgag tatcgttaat aaaattgatg tgtatcagct
    13081 gcatcgccca acctcccgat tttgcgcaga agaacttgta gctattatta taaatgcagt
    13141 aaaaaaggag tatgaagaag tatgaatcaa acattgaata tacagcaaac agttgtccaa
    13201 gtacaaggaa atttagtaag tgatatgggc ggagaaaaag tgatgctcag cattgagaac
    13261 ggtaaatact ataatttggg ggaaatgggc ggtgtgatat gggatttgct tgtagaacct
    13321 atttgtattg ctgaactcgt tgaaaaatta gtaagagaat acgatgttga acgaaatatt
    13381 tgtgaagcac atgtaatctc atttctatct atgttagagc aagagaattt agttaaactt
    13441 gtagggtagt aggttgtgag tgttatgaat ttttataaga agctaaagac gctttgttca
    13501 ctacatccta aaacatgttt attattagga gaggcatttg tttatctggc ttgggcgcgc
    13561 attttaaaag cgctaccgtt tgcaaaagta gtgccattac taggcgaaca aatgaatgaa
    13621 acatcaacgg atgccagtca tacgaacttg attatactgc aagatatttc agatgccgta
    13681 catgctatga gtttgcatac atattgggaa agtatgtgcc tagttagggc catcgcggca
    13741 atgaaaatgc tagaaaggcg ggggattgag agtaccttgt atttaggaac ggcgcgagat
    13801 gagaatgggc agatgattgc acatgcctgg ttgcgaagtg ggccgtttta tataaccgga
    13861 gcagaggaaa tgcatcgatt tagtgtagta gggaaatttg cccgcaaact gggctaagta
    13921 taaagggaga ttagcatgca agtaggttat acgttaaact tgaattgtgt tccaacagag
    13981 ttaagactat tactcatatt gctgcaagat gagggaaatg tagatgaaat aaatttgcaa
    14041 cacataaatt ggaatacatt cttagagtta gcaatgcatc atcgagtgtt tcctatgtta
    14101 tacagacggt tgcagaagtt gaatttgcca atagacgctt ctattttaca agcgttgcac
    14161 caagatttta aaaataatac ctttcaaatg ttgcatttga gcgcggagat gcaatacatg
    14221 agtcgtttac ttgcagacag aggaatccgg tctctgtttt taaaaggccc tatactagct
    14281 atggaactgt atagagacct atctttacga acgtcttgtg atttagatgt actggtccca
    14341 ttagcagatt tgcagcgggt agaagaactg ttaatagaac agggatatga aaaggatgac
    14401 tatattgaaa ctgtacttgg agattggaaa tggcgacatc atcacgttac gtactttcat
    14461 cctgtaaagg gaattaagtt tgaggtacac tggcgtttaa atccgggccc cgctatagag
    14521 cctcgttttc aggatttatg gcaaagaaga cgaacgcgtc gttttggtaa tgaagatgtt
    14581 gcatttttag ggcaagaaga tctattcttt tttttggttg cacacggtgc tcgtcatggt
    14641 tggtcgagat tgcgctggct tctggacatt catcaatttg taaagcagga tgtagattgg
    14701 aaaaaggtca gtcgcacctt gcaagcacat gggtacttac gagtgggggg gcaagcgctc
    14761 atactcggct cttctttatt aaaaacaagt ctttcaacaa atatggtcac actgctaaaa
    14821 ggaaaacatc ctgagcgctt ggcgcaggaa gctgtttttt atttagagag catgattaat
    14881 ttacatacag agccattgcc ccatgatgta tctgtgtacc ataaaaagca tttggtttct
    14941 ctaatgtctc ctatgcaaaa gacgatgttc ttaataagct ttttgtatcc atatccagaa
    15001 gatgcgaaga cattgccact tccaaaatca ttgcactttt tgtatttccc cttacgtccg
    15061 gccatttggg cgtggaagaa aattgtgcga taggaaaggg ggtaaataca tgaaagaact
    15121 gcgatattat atgagagaat tgcatatgtt ctcgggaaaa gttttatata taaatatgat
    15181 agcgatggtg ttgatcagtt tacttgaagg tgctggtatt ttattgttaa ttccaatgat
    15241 tcaggcaagt gggattgtgg gagaaatggc aggtgcttct tggttagaaa acttttttgc
    15301 atttgttaat aaagtaccgg aaacatgggc acttcctgtt gttttactga tatatgtaat
    15361 tttaattttg tttcaaacca tcatccagca aaaattgaat gtgagaaata tgcagatttt
    15421 aataaaattc acaaattcta tacgcttaaa aatctaccgt tcgctgttag aagtagaatg
    15481 gagctttttt gtgaaaaaac gaaaatcaga tttaattaat ctgctaacga gtgaatttgg
    15541 ccgttttgta aatggtataa acttatgttt acaactactg acttcttttt tatttacctg
    15601 tatccaaatc ggcattgcat tttgcttgtc acctagtatt acgttattcg tacttgtatc
    15661 ggggttacta ctaagctatt tttctagacg ttttattaag cgttcacaat cacttggtag
    15721 taaatcgact gatattgcaa aagattatct cagtggcata acggatcact ttaatggtgt
    15781 aaaagatatt aaaagcaatg cgttagaatg ctcgcgctat acatggctac aaacatggtg
    15841 tgaaactgtg caaaaagagc aattggctta cgcaaggttg agcaatagct cacaactgtt
    15901 ttataaagtc gtatcgacta tactggtcgc actcctcatc tacgtttcta ttcaaatgtt
    15961 tcagtcgcaa ccagcacagc tactccttat tgtattaatc ttttcgaggt tatggccaag
    16021 gtttactggt cttcagtcta acttagagca ggttggagca actattccag tttttcagtc
    16081 gctgtttcaa cttcaacaac aatgcgaaaa attacgtgaa ttgaatcttg ccaatcagga
    16141 agaagtagtt cctttgcaaa tacaagaggg gcttacatgt aaaaatcttt cctttcaata
    16201 taaaaatgaa gggaatacgt atgcgttaca aaacataaat ttacatattc ctgtaaacag
    16261 catgacagcc atagctggtc gttcgggggc aggaaaaagt acgcttattg atttgattat
    16321 gggattgatg cagccggatg ttggaaacgt gtatgttgat agcaagcctt taacacagca
    16381 agaactacca gctttacgaa aagaaatgag ttatgtggcg caagatccgt ttttatttaa
    16441 tgcaagtata cgagagaatt tattgattgt aaggccagat gctaccgaga aagagctatg
    16501 ggatgcttta gagttcgcat cggctgtatt tgttaaacaa ttacaacaag ggttggatac
    16561 agttatcggt gataggggtg ttcggttatc ggggggagag cgccaacgtc ttgttttagc
    16621 acgtgctatt ttacgaaaac caactatttt agtgcttgac gaagccacaa gtgctctaga
    16681 tacggaaaat gagagacaca ttcaacaagc actcgagcgt ttaaaagggc agatgacgat
    16741 cattgtaatc gcacatcgtt tatctacgat tgcaaatgca gatcaggttg ttgtaattga
    16801 taaaggagaa gtagtacaag caggaagctt taccgatctt gcaaaaaacg acaaaggttt
    16861 atttcataag ctgttaggta atcaagtaac gttgccgact gaacaaaaag tggctggagt
    16921 tttacaatat cgttaaacta tagcttattt gtaatgtgaa ttttcatcac attacaagcg
    16981 gtattaccgt ctttgtattt atatataaag ttacaatcat ccctggtgta gacgcggaaa
    17041 ggaggtgaga tcatgaaagt agtaaaaaaa atgctggttc tatttatgtt tataagtgca
    17101 tttacttttc ctacctctgc ccttgcatca ggatataatt atcaacaaaa aaacacatat
    17161 caaacatacg tatatcaggt gaaaacgtat tacgacacta gtaaacaaac aaactattac
    17221 tcttcttcaa aaggaaacag tcattataca tacaggtatg attgctatga cgattacaag
    17281 gattccattg atatttggag agattggtat tgtaactggg actgggaatg gttttgtaaa
    17341 tggtacgaat ggctatgggg aaaaaagaaa taggaacatg agcttcgctg catgcagtga
    17401 agctttttta tctgaatctt catacgatat aataaattta aatttcataa aaattgtctc
    17461 atagaggaga accatatgaa gcatcaaaca tcgagacttt tatatgtagg tatttttatg
    17521 ttatgttgtt ggggcatact tggccttgta gtaaagcaaa catcccatgt atctgtaatg
    17581 gagcaagttc ctatagctgt agatacactg gctccggctg tggcacatac accggtactt
    17641 tctacaaatg cttatcaggt tatgcggcta aaaggacaag tgcgcgcgac attacacgtg
    17701 ctgttttata tgtaaagagt gaagggacat cgatacagat tttctatgca aagaacagac
    17761 tctgtatatc aagcggacat ccctgcagaa gctgtagcct ctgattttac ataagtaagt
    17821 cttattacgg gggaacgtat aaaaataacc gcggtcatta tgatttgatt tcagtaggcg
    17881 gcaatgatga tatcatggta tatctaggtt ggagtatgga tgccgatggt attgcatgga
    17941 taagtgaggt acttgctgcg caccctgatc gaaaggcaat tttacatttt catgagtata
    18001 tgcttgcgac aggaacaaga caccctctcg gagagaaatt gtatcaagag atcatgttaa
    18061 aacatcctaa tgtgtttgcg gtactctctg gtcattatca tgaaagtcag cagcttattg
    18121 atgaaataga tgatgatgga gatggaaaag cagatcggaa agtatagcaa ttacttgccg
    18181 actatcaagc tggccctgag ggcggacagg gggatatgcg cttgttgcat tttgatacga
    18241 tacgaaatcg tattattgta aatacgtatt caccatacct aaacgactat aatttttatg
    18301 atacaaatgt gtatcctgca aaagatgagt ttgtgatgaa cttagattta acgccgcaga
    18361 aaaaacaagt cgcgacagat tattttgcag taaatgtcta tacagacaat gtaattggca
    18421 aagtagaacg tgtaaatagc ggcggtattg caagggcaac atggaataat ttgaagtcta
    18481 atgcatggta tgcgatagtg acagacacgt ttacagggca agcaaggtca gatatccaga
    18541 cctacgtaaa agatcgtaca gttcattcaa ttaccaagaa atcacatact caggcaaact
    18601 cgatatatga aaaaggtaat gccatgtggt tgcacgtcac gctatttagc ttttggatcc
    18661 tatgtagtgt catggtcatt ttagcaggag ctatttttta tcaaatgcgt aagagataat
    18721 agaaaaggtt cagcatgctg caggtatatg ctgttatata aaatggaata gaggatggga
    18781 gaaatggaag catttattta cgatttattt aacgaagatt tgttatttac agctgctgaa
    18841 cggtttcaga tagaacggaa ttcactagaa aaggtcagta catctgaaag ctttatttat
    18901 agttgtattt gtcaaggaca agagatgata ttacgtatca cacatagctc ccatcgttcc
    18961 gcaatagaga ttgaaggtga aatggaatgg attgcacact taatttcaca aggtgtgcca
    19021 gcttcacgcc ctgttctctc tgtacatagt aacgtgatag aggagattcc tacaaaagaa
    19081 gggcagtttt ttgtgacggt gtttgaaaag gcgcccgggc ggcatccaaa tattcatgat
    19141 tggaagcgcg acttttttat agaatggggt agaacaacgg gtgctatgca taaagcagca
    19201 gtcttgttcg attatacaac caagcgtcca atgtggcaga atgaatataa tattacagcg
    19261 attcatacgt acggtgagcc tgatttgatt gaagtgcagc ggcagctcat ccgtgatcta
    19321 gaggctttac cgaaggatga gagcgtctat ggtattattc actctgattt tgaggacggc
    19381 aacttcttca ttcatcatgg tacaattcat ccatttgatt ttgatgagtg tcagtatcat
    19441 tggtttgcct atgatattgg caatgcagtg cgtgcagcct catggtttgt tgctgataca
    19501 gattctgtat atacagtaga ggaattttta aacgattttt tagaaggcta ttatagtgag
    19561 tatcacttag attttcattg gatcgaaaaa cttcctatat ttatccgttt acgcgactta
    19621 tgtatttatg tatatctcat tggtaagcgt ggtcacaata tgtccgaggg ggagaagcgt
    19681 tttttagcaa gcatgaagga agaaattcgt gcaaaaaaac cttgtgtaca aatcgatgtt
    19741 agtcaaatac gtcgttatta agaaagaggt tccatatgtc atggaatcct tttttgcagg
    19801 atgagaagag ctaccaaaaa ggaaaaaagt catttctcgt taagtaaact tatggagctt
    19861 ctaagcaaat gattagacga atagaagggt atgactatat aataggcttc attattacac
    19921 ataatgaaat gttttgtaag aatctttctt acatggaatt tgatacaaag aaggtgtgtt
    19981 aatgaatata aaaatatctg tattagatct agcacccatt gtccaaggag gtacggcgac
    20041 agactcgttt cgtaatacac tggatttggc gcagcatgcg gaaaaatggg gatataacag
    20101 gtactggctg gcggaacatc ataatatggc tggtgttgcg agttcagcta cctctgttgt
    20161 aattggttat gtggcaggcg gcacatctcg cattcgtgtc ggctcaggcg gtatcatgct
    20221 tcctaatcat gcaccactag tcatcgctga gcaatttggt acactggctt ctatgtaccc
    20281 aggtcgtatt gatcttggac ttggacgcgc accgggaaca gatcagctta cagcacgcgc
    20341 gctgcgccgt gatttacgaa atgctgacga ctttccggag caactagaag aattacgtgc
    20401 gtacttcgcc ggcgatgtag aaaatgttcg agcagtgcca ggtgaaggac tagatgtacc
    20461 gatatggctt ctgggctcaa gtggattcag tgcacgttta gcgggacaac tgggcttacc
    20521 atttgcattt gccagtcatt tttctcctga ctatacactt cctgctattg aagcgtatcg
    20581 cagtacgttt acaccatcac cagtattgga taaaccatac gtcatggtag gtgccaatgt
    20641 gattgtggca gaaacggatg aaaaagcgcg ctatcttgca acatcgcagc agcaacaatt
    20701 cctcaatctc attcgtggcc gtacagcacc gctgcagcca ccagtagaaa acatggatta
    20761 cttgtggagc gaatatgaaa aggcagcgct tgaacgtcaa tttggttcag caattgttgg
    20821 cagtcgtgaa actgtaaaag caaagcttga agactttgtg aacatgaccg gtgcagatga
    20881 agtgattgcg agcgcgcaca tttttcatca cgatgaccgg ttacattctt atgaaatgtt
    20941 agctgaaatt gtaagcaggt aaaaactctc tcaccggagg gtttttttct ttgatatact
    21001 agagagcaag aaagacagcg gaggaagtac acatgaaagt tcgttacaaa ttaattttgc
    21061 tagcactact tgctttagcg gtaatacgcg tgtttgattg gttcggtgta tcacctgatg
    21121 attttccagc agaatataaa atgccgcaaa agcaagagta atagattgtg agataggggg
    21181 gatgctatga cagcggaatt gcttgcaaga ataaaagaaa cagaggaggt gcaatggcgt
    21241 aacccatacc tcctgctgtt tgcgaccgca attcacaacg cacgtattac agcggaaaat
    21301 gtgaaagcag tggaagagcg tttacgcaga tttgagccat atattgcgaa ggtatttccg
    21361 caaaccaatg gtgttattga atcacctctc attgcaatac caactatgca gaagcacctg
    21421 caagtaaaag ggaagttatt attaaaatgt gatagccact ttaccaattt ccgggtcgat
    21481 taaagcaagg ggcggtattt atgaggtgct gaagcatgca gagcaattgg cagtaaggca
    21541 agggaggttg gcattggaag attgctattc tcgtctagat agcgaagtgt ttcgtacatt
    21601 tttctcacaa taccgcatcg cagtcggctc tacggggaat ttaggactca gcatcggcat
    21661 aatgggagca atgcttggtt ttcatgtaac ggtacatatg tcagtcgatg ccaaagcatg
    21721 gaagaaaaag ttacttcgtc aaaaaggtgt aacagtcatt gaatatgaat caatttactt
    21781 ggaaccgtct gctctggcgg gcatgcttgg acctatacac gttcccaatg atcagatcag
    21841 gaaacacaca tcgtttgggc tacaggggga agtatggtac ggcaggaaga gatgcagacg
    21901 tattataata aaggaaaaga aacctctaat ctagaattat cttgatttag taatgtatga
    21961 aaaatattgt tagattataa tagttctagg ggtatgttta tcatcagggg agggtataaa
    22021 atgaaaataa aagcagcgac tttgttgctc ggagcagtgg ggatgtttac cacagtattt
    22081 tcatcgtcta cacaggctaa cggtacgctt ttaaatgcgc cattgatttc tcaaaagccg
    22141 gaactcaata acggatgcga agttacgagt ttagccatga tgctacaata cggtggtgta
    22201 cctgttggga aaatgacatt ggcacatgaa gtcgcaaaag atcttacacc gtatcgaaaa
    22261 gtgggaaata caatttattg gggaaatcct aatactggat tcgttggaga tattacaggg
    22321 cgttctatcg gttatgcagt ttatcacggc cctatctatg cgttagcgaa taagtatacc
    22381 aatgcaatcg acataacagg tcaatcattt aaggaagtaa caaagcagtt agatcgaggt
    22441 aaaccggtct gggtaatttc gacaagtatt tttgacaccg taccttggaa cgagtggcaa
    22501 accattcaaa cgccgaccgg accgcttaca atgacgttcc gcgagcacag tgtattgcta
    22561 acgggatatg atagtacata tgtatatttt aatgacccac ttgcaaatgt gaaaaatcgt
    22621 cgcgtatcaa aagccgcatt tattcgtggc tgggaacagt ttggtagaca agcagttact
    22681 tttggttcgt ctaaaatcat gatggacagt ccagcgcaag gaagcagctt aagtggcgtt
    22741 cacaatgtct ccggttggtt cttagatgaa agcggcgtgt caaaggtgga agtactggta
    22801 gatggtcaag tgatgggaca agctacatat ggaaacgccc gtccggatgt gcaacgtgca
    22861 tatcctgagt ataacaatgg atatgcaggc tttcagtatt ctcttgatac aaatcgtttg
    22921 agtaacggtg tgcatacgat taccgtaaga ggtacgggga aaaatggtaa gacggttaca
    22981 ttgtcaggtt ctaccgtcac agtatccaat gccattgcga tgatggacac acctacaccg
    23041 aatatgcagc ttagcggtat tcacaacatc gtgggctggt tcttagatgc aagtggtgtt
    23101 gccagagttg aagtattagt ggatggagct gtggtcggcc aagctgtgta cggagatgcg
    23161 cgacctgatg tacaacgtgc gtatcctcaa tataaaaccg gaaatgctgg ctatcattat
    23221 gcattagaca caaaaacaat ttctgagggg gttcataagg taacgattag aggggtcggt
    23281 aaaaacgggg aaacagtaac attaccagaa cgaacgatta cagttgcgaa tgttaaaggt
    23341 gttctcgata atccagtttc taatatgaca ataagcggta ttcataaaat cggcggctgg
    23401 ttcttggatg agagcggtgt cgcgaaggtt gaagtattag tagacggtgc tgcggttggc
    23461 caagctgtgt acgggcagga aagaccagat gtattgcggg catatccaca atccaaaaat
    23521 ggaaatgctg gctacgtcta tgaactcaat acaatgactt taaaagaagg caagcataac
    23581 atcgccgtac gagaaacaag taaaacaggt cgcgtcacaa cacttcctgc tgctcctgtc
    23641 acggtaacaa acacacacag ttatattgat gcgcctgatg caaaagaaac aatcagcggt
    23701 aactacacag tgtccggttg gtttttagat cgggcaggtg taggaagagt tgaagtgtta
    23761 atagacggtg ctatggtagg aaacgcggta tacggccagc caagatttga cgtacagcaa
    23821 gtatatccgc agtacaacaa cttaaatgcc ggctaccgat ttgtattgga tacgaaaaaa
    23881 ttcagtaatg gtaatcatac cctaacaatt cgagagc
//
