LOCUS       NZ_CP095376            10801 bp    DNA     circular CON 06-NOV-2024
DEFINITION  Amycolatopsis sp. FBCC-B4732 chromosome, complete genome.
ACCESSION   NZ_CP095376
VERSION     NZ_CP095376.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. FBCC-B4732
  ORGANISM  Amycolatopsis sp. FBCC-B4732
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 10190959)
  AUTHORS   Choi,A.
  TITLE     Complete Genome Sequence of Amycolatopsis pretoriensis strain
            FBCC-B4732
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10190959)
  AUTHORS   Choi,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-APR-2022) Bioresources Collection & Research Team,
            Nakdonggang National Institute of Biological Resources, Donam 2-gil,
            Sangju-si, Gyeongsangbuk-do 37242, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 75.1x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023008405.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 10:39:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,364
            CDSs (total)                      :: 9,298
            Genes (coding)                    :: 9,177
            CDSs (with protein)               :: 9,177
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 121
            CDSs (without protein)            :: 121
            Pseudo Genes (ambiguous residues) :: 0 of 121
            Pseudo Genes (frameshifted)       :: 50 of 121
            Pseudo Genes (incomplete)         :: 81 of 121
            Pseudo Genes (internal stop)      :: 14 of 121
            Pseudo Genes (multiple problems)  :: 19 of 121
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:14:56
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5372864
            Orig. end                         :: 5383665
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP095376.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from NNIBR.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10801
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="32"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10801
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10801
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5801](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5801
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(182..195)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            618..2225
                     /locus_tag="MUY14_RS23105"
                     /old_locus_tag="MUY14_23105"
     CDS             618..2225
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658040.1"
                     /locus_tag="MUY14_RS23105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_23105"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_247011750.1"
                     /sec_met_domain="Pkinase (E-value: 3.8e-47, bitscore:
                     159.9, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVVWRATDVRLERDVAIKQILPQPGVSETERDNMRQRAMREAKN
                     AARFQHPNAIVVFDIAEHNGDPCLVMEYLNGPSLSTILSEEGTLPLGRIARIGEQVASA
                     LVAAHRAGIVHRDVKPGNILIDETGTAKITDFGISRAAGDMTLTATGLIGGTPAYLAPE
                     LARGADPVPSSDVFALGATLYQAIEGTTPYGNTTNQLALLYAAANGQINPPVQAGAATA
                     LLMSLLRSEPGERPSMAEARERLAALARTEPGGMSASPPLLSGNAGRKPAAPAESGDRP
                     PWQRTDQPAPQSPPVGTPVPANKAASNPPRPTAAFMPMRSPAAPPNTPPRPMPAAAPTA
                     RAPQYSSNTAKPDNKRKYALFAGAGAAVVVAAVVLFLVLNSGSDGAGGDQTAQSPGAQP
                     TTGQTTPKSGQSSATNAPAGLGQTIPEGKITDFQAAGHAITGFYDNPAGGWSKLTPAAQ
                     QVYGSEQAFAEYWANNKVSDYASARADSGGANSDGSITMNLTVNGTRNAYRIVTVGGTM
                     LIDADTRLGPQGAPGSGY"
     gene            2279..2584
                     /locus_tag="MUY14_RS23110"
                     /old_locus_tag="MUY14_23110"
     CDS             2279..2584
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004560769.1"
                     /locus_tag="MUY14_RS23110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_23110"
                     /product="hypothetical protein"
                     /protein_id="WP_192782430.1"
                     /transl_table=11
                     /translation="MAENGASLPGQNPRFHEDLVGLDPYDPEARAFAEHLDRMERSGPN
                     FTIEAALDGVADFADSSNRLGGLRYWVSALIVVLIVLGVIVTAWDIVVHALAWLAA"
     gene            2604..3041
                     /gene="msrB"
                     /locus_tag="MUY14_RS23115"
                     /old_locus_tag="MUY14_23115"
     CDS             2604..3041
                     /EC_number="1.8.4.12"
                     /GO_function="GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013224520.1"
                     /locus_tag="MUY14_RS23115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_23115"
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="WP_247011753.1"
                     /transl_table=11
                     /translation="MKPVVGATPRVVKSEQEWRQQLNPDEYAVLRQAGTERPFTGEYTD
                     TKTTGVYECRACGAELFRSDTKFESHCGWPSFFDPADSDAVLLREDRAMGMKRIEVLCG
                     SCHSHLGHVFEGEGYPTPTDQRYCINSISLKLVPEPGTPPA"
     gene            3116..4027
                     /locus_tag="MUY14_RS23120"
                     /old_locus_tag="MUY14_23120"
     CDS             3116..4027
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013224519.1"
                     /locus_tag="MUY14_RS23120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_23120"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_247011755.1"
                     /transl_table=11
                     /translation="MTDTWGVPGPVFAGLYLALLLLPALAAAVRGGLLLRGHAGGTPKR
                     PEELALLTGGRRRFGEYVVAGLLDQQVIRLAGNGRLSRVKGTTIDSAGREALSRIGKNG
                     SAVERVCDAAAEHKTALELETSLIGRGLLADPRKLRSTWVTTAVAYWVVVAVGLVRLIA
                     GASSGHPVGILLGLLAVGVVVAITVTVKARKPREVKATFAGRAAAEAARRAGTLVAGPA
                     GAVAAGGLSAHPDKDVRLAVTRAAQHSNARAHSRRSRTRFAGAGGGAAVGYYGGSSCGG
                     GGGSSCGGGGSSCGGGGGGCGG"
     gene            4094..5008
                     /locus_tag="MUY14_RS23125"
                     /old_locus_tag="MUY14_23125"
     CDS             4094..5008
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013224518.1"
                     /locus_tag="MUY14_RS23125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_23125"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_247011757.1"
                     /transl_table=11
                     /translation="MNDPWGISGPDFVVLYIALLGVVLLVRIIVSGVMAGRAMRADDGR
                     PVPPPTVYQLAFLAGGPDRAVDAAVAALVDRGQLRVNSYKQVSQAGARPSEPLEQAVYD
                     VAQLKTTATIRAYVRRSAVMKALETGLDQQGLLVSAAAKRQSRTIGLVLQLAVLAFGLV
                     RLVNGISLGRPVGVLVFLVLIAAVLAIVAAVRRSKTGARQPSAAGHRVLGQARSAASGP
                     VPAGMLAGGVLLGGAAAAVALGGWSMYPDEELSAALTPPASFGGGGSSGGSSCSSGSSC
                     SSSSSCSSGSSCGSSCGGGGCGG"
     gene            5001..5801
                     /locus_tag="MUY14_RS23130"
                     /old_locus_tag="MUY14_23130"
     CDS             5001..5801
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013224517.1"
                     /locus_tag="MUY14_RS23130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_23130"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_247011759.1"
                     /sec_met_domain="DUF692 (E-value: 4e-83, bitscore: 277.8,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGELGIGIGWRHELDLSIARLPGVDWVEVVAENLHADHLPETLVA
                     LRRKGLPVLPHAVSLSLGGAEPLDTGRVQHLAEIARAVDAPLVSDHVCFVRAGGLDSGH
                     LMPLPRTREALDVLVANVRLAQSIVDVPFALENIAAVLDWPDNELTEEQFLTELTDRTG
                     CRLIIDVANLYANARNIGTDPVAFLDGIPWERLAYVHMAGGIERDGVYHDTHAHPVLPE
                     VLALLTELRRRTDPPGVLLERDDDYPSDDELAAELAALRAAVTG"
     gene            5798..6136
                     /locus_tag="MUY14_RS23135"
                     /old_locus_tag="MUY14_23135"
     CDS             5798..6136
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004562080.1"
                     /locus_tag="MUY14_RS23135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_23135"
                     /product="hypothetical protein"
                     /protein_id="WP_247011761.1"
                     /transl_table=11
                     /translation="MSREELARRQAELLKALLASGPAPAGFDASRLQVEASVLRRKHGR
                     VLAYQRPEVAEALGERYGPLFAEFTSGRPKLAAERSGAYADEFVAWLIDRGHLPKPRRG
                     LRDWLRRR"
     gene            complement(6296..7636)
                     /locus_tag="MUY14_RS23140"
                     /old_locus_tag="MUY14_23140"
     CDS             complement(6296..7636)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0008410 - CoA-transferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013224515.1"
                     /locus_tag="MUY14_RS23140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_23140"
                     /product="CoA transferase"
                     /protein_id="WP_247011764.1"
                     /transl_table=11
                     /translation="MREAVEGVWEALTGSRPGPFALTGTEDVLPGPYRVAAAATASIAA
                     ATLAAGELLKLRGIEPGVVTADTRHAAAAFHSEQLLRVDGTGAESVWAPLSGNYRAADG
                     WVRLHCNYPRHEAAVCWGLGVPGTRGAVAKAVAGRPAREIEHAVVSAGGAAAELRTPED
                     WAAHPQGSAVASLPLVSLEPLEAAPKRTLFYSDRPLGGVRVLELTHVLAGPVAGRVLAA
                     HGADVLHVGAAHLPRVEALVRDTGQGKRSTFVALDTEGGRARLKKLISRADVLVQSFRP
                     GALEKIGFGPSELAELRPGLVIADLSAYGWEGPWARRRGFDSLVQMSNGMAWGPEEPSP
                     LPVQALDHATGWLAAAAVMTAVHRQLTDGGTWRARLSLAGTGRWLDSLGRKDPAAVEVD
                     YSDLMEDADSGYGRLTRVRMAGGLPGAEPHWDFGTRLPGVDKPTWTP"
     gene            complement(7636..8328)
                     /gene="hemQ"
                     /locus_tag="MUY14_RS23145"
                     /old_locus_tag="MUY14_23145"
     CDS             complement(7636..8328)
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983668.1"
                     /locus_tag="MUY14_RS23145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_23145"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_247011766.1"
                     /transl_table=11
                     /translation="MARVNYNELNDTIRYTTWSVFRIEPGRLGEDRGTAGRETAEYLDG
                     LEAKGVVVRGVYDLSALRADADYMIWWHAEEIEQVQAAYAGFRRTPLGRASTPVWSQTA
                     LHRPAEFNKSHIPAFLAGEEARKYICVYPFVRSYEWYLLPDADRRKMLADHGKEARDYP
                     DVRANTVASFALGDYEWILAFEADELHRIVDLMRHLRGTEARLHVREEIPFYTGTRVPP
                     AELVAALP"
     gene            complement(8385..9785)
                     /gene="hemG"
                     /locus_tag="MUY14_RS23150"
                     /old_locus_tag="MUY14_23150"
     CDS             complement(8385..9785)
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658031.1"
                     /locus_tag="MUY14_RS23150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_23150"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_247011768.1"
                     /transl_table=11
                     /translation="MKRVAVVGGGVSGLTAAYRLRRLLGPDAEIVVFEKTKTPGGKLRT
                     AELAGVPYDVGAEAFLVRRPEMLALVRELDLDVVHPTKARAKIHAGGSVTGMPAGTLMG
                     VPASAESVAGVLSEAGRRAVEAEVSLPELRLPSGDLPLGPLLRERFGDELVDRLVDPLL
                     GGVYAGGADGLGLRATMPGLASALAAGAGSLTAAAAAQLPANPSTAPVFGTVPGGLGTV
                     IDRLTEASGAELRTGLPVCDIERHGAGWRLRIGAAPTAHAPADNTVEADAVVLAVPAPS
                     ARRLLADLVPAASAAFGEVELASMAVVAMALPPGTRLPEASGILIGHGERDASGRPYAS
                     KAFTFSSRKWGHFGTGPVLVRGSVGRFGELGALQADDVELVRVVRADLARLTGVTTAPI
                     ETLVTRWGGGLPQYGTGHLERVERIEKAIAAVPGLAVAGATLHGVGLPACVATAEAAAQ
                     RIAAQLAE"
ORIGIN
        1 gggcaccgcg gccggcatcg cgatcggcct ggccgccacc accatcgcgg cggcgctgtc
       61 cttcgggctg gcccgcctgc tcgggcgcga cctcgtcacc cgccacctgc accggtccgc
      121 cgtccggacc gtgaacgacc ggctctccga cggcggcgtc ctggccatca cctcgctgcg
      181 gttgatcccg gtcgtcccgt tcgccccgtt cagctacctc tgcggcgtgt cgtccgtgcg
      241 accgttcccc tacctcgccg gtacgctgct gggcagcgtg cccggcaccg tcgccgtggt
      301 cgtcctcggc gacgccctga ccggcggaac gccaccggcg ctgctcgtct gttacggcgt
      361 gttcgcgctg gccggggcga tcggcctggt ccgggtcttc cggaaacggg cgccggtgcc
      421 cgcaccggag cccgccggac cggctggctg acgcgaagag caccgggccg accgctacac
      481 tcgatcgggt gcgcgaagcg gaaacgcgct gagcagggtc accaccaccg ggaatttcgt
      541 caggagcagt cgccatcgac accggtcagc tgatcgcggg gcactaccgc ctcgtcgagc
      601 acattggtag cggtgccatg ggagtcgtgt ggcgcgccac cgacgtgcgc ctcgagcgcg
      661 acgtcgcgat caagcagatc ctgccccagc cgggcgtctc cgagaccgag cgcgacaaca
      721 tgcgccagcg cgcgatgcgc gaggcgaaga acgccgcccg gttccagcac ccgaacgcga
      781 tcgtggtgtt cgacatcgcc gagcacaacg gcgacccgtg cctggtgatg gagtacctga
      841 acgggcccag cctctccacg atcctgtccg aggagggcac gctgcccctc ggccgcatcg
      901 cccggatcgg cgagcaggtc gcgtccgcgc tggtcgccgc gcaccgcgcc gggatcgtgc
      961 accgcgacgt caagcccggc aacatcctga tcgacgagac cggcaccgcg aagatcaccg
     1021 acttcggcat ctcgcgcgcg gccggcgaca tgacgctcac cgcgaccggc ctgatcggcg
     1081 gcacgcccgc gtacctggcg cccgagctgg cgcgcggcgc cgacccggtg cccagctccg
     1141 acgtcttcgc cctcggcgcg accctctacc aggcgatcga gggcaccacg ccgtacggca
     1201 acaccaccaa ccagctcgcg ctgctctacg cggccgcgaa cggccagatc aacccgccgg
     1261 tgcaggcagg cgcggccacc gcgctgctga tgagcctgct gcgcagtgag ccgggcgagc
     1321 ggccgagcat ggccgaggcc cgcgagcggc tcgccgcgct ggcccggacc gagcccggcg
     1381 gcatgagcgc gtcgccgccg ctgctctccg gcaacgcggg ccgcaagccc gccgccccgg
     1441 ccgagagcgg cgaccgcccg ccgtggcagc gcaccgacca gcccgcgccg cagtcaccgc
     1501 cggtcggcac gccggtgccc gcgaacaagg cggcgtcgaa cccgccgcgc ccgaccgcgg
     1561 cgttcatgcc gatgcggtcg ccggccgcgc cgccgaacac cccgcccaga ccgatgcccg
     1621 cggccgcgcc gacggccagg gccccgcagt actcgtcgaa caccgcgaag ccggacaaca
     1681 agcgcaagta cgccctgttc gccggggcgg gagccgcggt cgtcgtggcc gcggtggtcc
     1741 tgttcctggt gctgaactcc ggcagcgacg gcgccggggg cgaccagacc gcccagtcgc
     1801 ccggcgccca gccgaccacg ggccagacca cgccgaagag cggtcagagc agcgcgacga
     1861 acgcccccgc gggtctcggc cagacgatcc cggaaggcaa gatcaccgac ttccaggcgg
     1921 ccggccacgc catcacgggc ttctacgaca accccgccgg cggctggtcg aagctgacgc
     1981 cggccgcgca gcaggtgtac ggcagcgagc aggcgttcgc cgagtactgg gcgaacaaca
     2041 aggtctccga ctacgcgagc gcccgcgccg acagcggcgg cgcgaactcc gacggctcga
     2101 tcacgatgaa cctgacggtc aacggcacgc gcaacgccta ccggatcgtc acggtcggcg
     2161 gcacgatgct catcgacgcc gacacgcggc tcggcccgca aggggcgccc ggctccgggt
     2221 actgagactt aacgcgccgc tggtgggctg acgggcgccg atggcttacc gtgggggtat
     2281 ggccgagaac ggagcttcgc tgccgggcca gaatcctcgc ttccacgagg acctggtcgg
     2341 cctggacccc tacgacccgg aggcgcgcgc gttcgccgag cacctcgacc ggatggaacg
     2401 ctccggcccc aacttcacca tcgaggcggc gctggacggc gtggccgact tcgccgactc
     2461 cagcaaccgc ctcggcgggc tgcgctactg ggtgtcggcc ctgatcgtgg tgctcatcgt
     2521 cctcggcgtg atcgtgaccg catgggacat cgtcgtgcac gccctcgcgt ggctcgcggc
     2581 gtaacgtgga tcgggtgaaa ggtatgaaac ccgttgtcgg cgcgaccccg cgcgtcgtga
     2641 agtccgagca ggaatggcgg cagcagctca accccgacga gtacgccgtc cttcgccagg
     2701 cggggaccga acggccgttc accggcgaat acaccgacac caagacgacc ggcgtctacg
     2761 agtgccgcgc gtgcggtgcg gagctgttcc gcagcgacac gaagttcgag agccactgcg
     2821 gctggccgtc cttcttcgac cccgcggatt ccgatgcggt gctgctgcgt gaagaccgcg
     2881 ccatgggcat gaagcggatc gaggtgctct gcggctcctg ccacagccac ctcgggcacg
     2941 tcttcgaggg cgagggctac ccgaccccga ccgaccagcg ctactgcatc aactcgatct
     3001 ccctgaagct ggtccccgag cccggaaccc cgccagccta aatccttctt aagccggcaa
     3061 cccaccgccc ttcctcgaac gtagtctccg cacacggacg agggagggcg gactcatgac
     3121 cgacacctgg ggcgttcccg gaccggtgtt cgcgggcctg tacctggccc tgctgctcct
     3181 gccggcgctg gccgccgcgg tgcgcggcgg gctcctgctg cgcggccacg cgggcggcac
     3241 gccgaagcgg ccggaagagc tggcgctgct gaccggcgga cggcggcgct tcggcgagta
     3301 cgtcgtggcc ggcctgctcg accagcaggt catccggctg gccggcaacg ggcggctcag
     3361 ccgcgtcaag ggcaccacga tcgacagcgc cggccgcgaa gccctcagcc gcatcggcaa
     3421 gaacggctcc gccgtcgagc gcgtgtgcga cgccgcggcc gagcacaaga ccgcgctcga
     3481 actcgagacc tcgctgatcg gccggggact gctcgccgac ccgcggaaac tgcgttcgac
     3541 ctgggtcacc accgcggtgg cctactgggt cgtggtcgcc gtcggcctgg tccggctgat
     3601 cgccggggcg agcagcgggc acccggtcgg gatcctgctc ggcctgctcg cggtgggcgt
     3661 cgtcgtggcg atcaccgtca ccgtgaaggc acgcaagccg cgcgaggtca aggccacgtt
     3721 cgccggccgg gcggccgccg aagcggctcg ccgcgccggg acgctcgtgg ccggcccggc
     3781 gggcgccgtc gcggcgggtg ggctgagcgc gcaccccgac aaggacgtcc ggttggccgt
     3841 cacccgggcc gcgcagcact cgaacgcacg cgctcacagc cgccgtagcc gtacccgctt
     3901 cgccggggcc gggggcggcg cggccgtcgg ctactacggc ggcagctcct gcggcggggg
     3961 cggcgggagt tcctgcggcg gcgggggcag ctcgtgcggt ggtggcggtg ggggctgcgg
     4021 cggttgaaac gccgacgcga gcgcgtgcgt ctcacagcta cggtaatcgc gactcactga
     4081 ggggagacgg gcgatgaacg acccgtgggg catttccgga ccggatttcg tggtcctcta
     4141 catcgcgttg ctcggcgtgg tcctgctggt caggatcatc gtgtccggcg tcatggccgg
     4201 ccgcgcgatg cgcgcggacg acggcaggcc ggtcccgccg ccgaccgtct accagctcgc
     4261 gttcctcgcc ggcggccccg accgggccgt cgacgcggcg gtcgcggcgc tggtggaccg
     4321 cgggcagctg cgcgtcaaca gctacaagca ggtcagccag gccggggccc ggccctcgga
     4381 gccgctggag caggcggtct acgacgtggc gcagctgaag acgacggcga cgatccgggc
     4441 gtacgtccgc cgctccgcgg tgatgaaggc gctggaaacc ggcctcgacc agcaaggact
     4501 gctggtgtcg gcggcggcga agcggcagtc gcggacgatc gggctcgtcc tgcagctcgc
     4561 cgtgctggcg ttcggcctgg tgcggctggt caacggcatc tcgctcggcc gcccggtcgg
     4621 ggtcctggtg ttcctggtgc tgatcgcggc ggtgctcgcg atcgtggcgg cggtccgccg
     4681 gtcgaagacg ggcgcccggc agccgtcggc ggcggggcac cgcgtgctcg gccaggcgcg
     4741 ctcggcggcg tccggcccgg taccggcggg catgctcgcg ggcggcgtgc tgctcggcgg
     4801 cgccgcggcg gcggtcgcgc tgggcggctg gtcgatgtac ccggacgagg agctcagcgc
     4861 ggcgctgacc ccgccggcgt cgttcggcgg cggtggctcg tcgggtggtt cgtcgtgcag
     4921 cagcggctcg tcgtgctcga gctcgtcgtc gtgcagcagc ggctcgtcct gcggttcttc
     4981 gtgcggcgga gggggctgcg gtgggtgagc tcggcatcgg catcgggtgg cggcacgaac
     5041 tggacctgtc catcgcgcgg ctgcccggtg tcgactgggt ggaggtggtc gcggagaacc
     5101 tgcacgccga ccacctcccg gagacgctgg tggccctgcg gcgcaagggc ttgccggtgc
     5161 tgccgcacgc cgtctcgctg tcactgggcg gcgccgagcc cctcgacacc ggccgcgtcc
     5221 agcacctggc ggagatcgcg cgggccgtgg acgcgcccct ggtcagcgac cacgtgtgct
     5281 tcgtgcgcgc gggcgggctc gactcggggc acctgatgcc gctcccccgc acccgcgaag
     5341 cgctggacgt gctggtggcg aacgtccggc tggcccagtc catcgtggac gtaccgttcg
     5401 cgctggagaa catcgcggcg gtgctggact ggccggacaa cgagctgacc gaggagcagt
     5461 tcctcacgga gctgaccgac cggaccggtt gccggctgat catcgacgtc gcgaacctgt
     5521 acgcgaacgc ccgcaacatc ggcacggacc cggtggcgtt cctggacggc atcccgtggg
     5581 aacggctggc gtacgtgcac atggcgggcg gcatcgagcg cgacggcgtc taccacgaca
     5641 cgcacgcgca cccggtgctg ccggaggtgc tcgcgttgtt gacggagctg cgtcgccgga
     5701 cggacccgcc gggggtgttg ctggagcgcg acgacgacta cccgagcgac gacgagctgg
     5761 ccgcggagct ggcggcgctg cgcgcggcgg tgacggggtg agccgggagg agctggcccg
     5821 ccgtcaggcc gagttgctga aggcgttgct ggcttccggc ccggctcccg cgggcttcga
     5881 cgcttcgcgg cttcaggtgg aggcttcggt gctgcggcgg aagcacgggc gggtgctggc
     5941 gtaccagcgg cccgaggtgg ccgaggcgct gggtgagcgg tacgggccgc tgttcgcgga
     6001 gttcacctcg ggacggccga agctggccgc ggaacgttcg ggggcgtacg cggacgagtt
     6061 cgtggcttgg ctgatcgacc ggggccacct gccgaagccc cgccggggcc tgcgagactg
     6121 gcttcggcgg cgctgaccgg ggtgttcctg gctgggtgtg cttcccgttc caggtcgccg
     6181 gggccgacgc ctcgacagcc tcttcccgca gcacgtccac gggcggtggc ggtgtcctga
     6241 atgactcatt caggaccttc gcccggcgcg ggttgcggga ccggctccgg cggcgctaag
     6301 gggtccaggt cggtttgtcg actcccggca gccgcgttcc gaagtcccag tggggctccg
     6361 cacccggcag cccgcccgcc atgcggaccc gcgtcaggcg gccgtagccg ctgtccgcgt
     6421 cctccatcag gtcgctgtag tcgacctcga cggccgcggg atccttgcgg cccagcgaat
     6481 ccagccaccg gcccgtgccc gccagcgaaa gccgcgcgcg ccacgtgccg ccgtccgtga
     6541 gctggcggtg caccgccgtc atgaccgccg ccgccgcgag ccagcccgtt gcgtggtcca
     6601 gtgcctggac cggcagcggc gaaggctcct ccggacccca ggccatcccg ttcgacatct
     6661 ggaccaggct gtcgaagccg cgccggcggg cccacggacc ctcccagccg tacgcgctca
     6721 ggtccgcgat caccaagccc ggccgcagct cagccagctc cgacgggccg aacccgatct
     6781 tctccagcgc gcccgggcgg aacgactgga ccagtacgtc cgcccggctg atcagcttct
     6841 tcagccgcgc gcggccgccc tcggtgtcga gtgccacgaa cgtcgaacgc ttgccctggc
     6901 cggtgtcacg caccaaagct tcgacgcgtg gcaggtgcgc cgccccgacg tgcaggacgt
     6961 cggcgccgtg cgcggccagg acccggccgg ccaccgggcc ggcgaggacg tgcgtcagtt
     7021 ccaggacccg gacgccgccc agcgggcggt ccgagtagaa caacgtccgt ttcggcgccg
     7081 cttccagcgg ctccagcgaa accagcggca gcgaagccac cgccgacccc tgcgggtgcg
     7141 ccgcccagtc ctccggcgtg cgcagctcgg cggccgctcc cccggcgctg acgaccgcgt
     7201 gctcgatctc gcgcgcggga cggccggcga ccgccttcgc gaccgcgccg cgggtgccgg
     7261 gcacgcccaa tccccagcac accgccgctt cgtggcgcgg gtagttgcag tgcaggcgca
     7321 cccagccgtc ggccgcgcgg tagttgccgg acagcggtgc ccagaccgac tccgcgcccg
     7381 tgccgtccac ccgcagcagc tgctcgctgt ggaacgccgc cgccgcgtgc cgcgtgtccg
     7441 cggtgacgac gccgggctcg atcccgcgca gcttcagcag ttcgcccgcc gccagggtcg
     7501 ccgccgcgat ggacgccgtc gccgcggccg ccacccggta cgggccgggc agcacgtctt
     7561 cggtgccggt gagtgcgaag ggtcccggcc gcgaaccggt gagcgcctcc cagacgccct
     7621 cgactgcctc gcgcactacg gcagggccgc gacgagctcg gcgggcggca cgcgcgtgcc
     7681 ggtgtagaac gggatttcct cccggacgtg cagccgcgct tcggtaccgc gcaggtggcg
     7741 catcaggtcg acgatgcggt gcagctcgtc ggcctcgaag gcgaggatcc actcgtagtc
     7801 gcccagcgcg aacgacgcga cggtgttcgc gcgcacgtcc gggtagtcgc gggcttcctt
     7861 gccgtggtcg gccagcatct tgcggcggtc ggcgtccggc agcaggtacc actcgtagga
     7921 gcggacgaac gggtacacgc agatgtactt gcgcgcctct tccccggcga ggaacgcggg
     7981 gatgtggctc ttgttgaact cggcgggccg gtgcagcgcg gtctggctcc agaccggcgt
     8041 cgacgcgcgc ccgagcggcg tccggcggaa cccggcgtag gcggcctgga cctgctcgat
     8101 ctcctcggcg tgccaccaga tcatgtagtc ggcgtcggcg cgcagcgcgg acaggtcgta
     8161 gacaccccgg acgacgacgc ccttcgcctc caggccgtcg aggtactcgg cggtctcccg
     8221 gccggcggtc ccgcggtcct cgcccagcct gccgggctcg atccggaaca ccgaccaggt
     8281 cgtgtagcgg atggtgtcgt tgagctcgtt gtagttgacc cgcgccatgc gtccatcctg
     8341 tcaccgcgcg ggggacgtcg ccgccacggg tcaggtgaga gcactcactc ggcgagctgc
     8401 gccgcgatcc gctgcgcggc cgcctccgcc gtcgccacgc acgccggcag cccgactccg
     8461 tgcagcgtcg ccccggcgac cgcgagcccc gggaccgccg cgatcgcctt ttcgatccgc
     8521 tcgacccgct cgaggtgccc ggtgccgtac tgcggcagcc cgccgcccca ccgcgtcacc
     8581 agcgtctcga tcggcgcggt cgtcacgccg gtcaggcgcg cgaggtcggc gcggaccacg
     8641 cggaccagct cgacgtcgtc ggcctgcagc gcgcccagct cgccgaagcg cccgaccgag
     8701 ccgcggacca gcaccgggcc ggtgccgaag tggccccact tgcgcgaaga gaaggtgaac
     8761 gccttcgacg cgtacggccg gcccgaagcg tcgcgctcgc cgtggccgat caggatcccc
     8821 gacgcctccg gcagccgcgt gccgggcggc agcgccatcg cgaccaccgc catcgacgcc
     8881 agttcgacct cgccgaacgc cgccgaagcc gcgggcacca ggtcggccag cagccgccgg
     8941 gccgagggtg cggggacggc gaggaccacg gcgtcggcct cgacggtgtt gtccgcgggc
     9001 gcgtgcgcgg tcggcgcggc gccgatgcgc agccgccagc ccgcgccgtg ccgctcgatg
     9061 tcgcagaccg gcagcccggt ccgcagctcc gcgccggaag cttcggtgag ccggtcgatc
     9121 accgtgccga gcccgcccgg gacggtgccg aacaccggcg cggtggacgg gttcgccggc
     9181 agctgcgcgg ccgccgccgc ggtcagcgag cccgcgcccg ccgccagcgc cgacgccagg
     9241 ccgggcatgg tcgcgcgcag gccgaggccg tccgccccgc ccgcgtagac gccgccgagc
     9301 agcgggtcga ccagccggtc gaccagttcg tcgccgaagc gctcgcgcag cagcggcccc
     9361 agcggcaggt caccgctggg cagccgcagt tccggcaggg agacctcggc ctcgacggcc
     9421 cgccgtccgg cttcggaaag cacgccggcc acggactccg cggacgccgg gacgcccatc
     9481 agcgtgccgg ccggcatgcc cgtcacgctg ccaccggcgt ggatcttcgc gcgcgccttc
     9541 gtcgggtgga cgacgtcgag gtccagttcg cggaccagcg ccagcatctc gggacggcgg
     9601 acgaggaacg cctcggcgcc gacgtcgtag gggacgccgg cgagctcggc cgtgcgcagc
     9661 ttcccgcccg gcgtcttcgt cttctcgaac acgacgatct cggcgtccgg accgagcagc
     9721 cgccgcagcc ggtacgccgc ggtcagcccg gaaacgccgc ccccgacgac cgcgacccgc
     9781 ttcacagctc gtgcaccagc ccgaccacgc gcgtcagcac gtccgggtcg acacccggca
     9841 gcacgccgtg gcccaggttg aagatgtggc cgtcggccgc cttgccctcc tcgacgatcc
     9901 ggcggacctc ggcttcgagg accggccagg acgtgtggag cagcgcgggg tcgaggttgc
     9961 cctggacgac ggcgtgcccg ccgaggcgcc gcaccgcttc gtcgaggggg atgcgccagt
    10021 cgacgccgac gacgtccgcg cccgcgtcgc gcatggcggg cagcagctcg ccggtgccga
    10081 cgccgaagtg gatccgcggc acgccgtacg cggcgacgcc gtcgaggacc ttcgccgagt
    10141 gcggcaggac gaactcgcgg tagtcccgct cggacagcgc gcccgcccag gagtcgaaca
    10201 gctggaccgc gtcgacgccc gcgtcgagct gggcgcgcag gaaggtcagc gcgacgtcgg
    10261 ccaggcggcc ggccagctcg tgccacagag ccggctccga gtgcatcagg gccttggtgt
    10321 gctcgtggtt gcggctcggg ccgccctcga tgaggtagct ggccagcgtg aacggcgcgc
    10381 cggcgaagcc gatcagcggg gtaccgccga gccgctcgac gagcagccgg acgccgtcgg
    10441 cgaccttcga gacgtggccg ggctccagct ccggcagtgc tttcaccgcc gcgaggtcgc
    10501 gcaccggcgc ggcggccacc gggccggtgc cgggcacgat gtcgatgtcg acgccggcgg
    10561 ccttcagcgg caccacgatg tcgctgaaga ggatcgccgc gtcgacgccg tggcggcgta
    10621 ccggctgcag cgtgatctcg gcgagcattt cggggtcgaa gcaggcgtcg agcatcggca
    10681 cgccctcgcg cagcgcgcgg tattcgggca gcgaacgacc cgcctggcgc atgaaccaga
    10741 cgggcgtgcg ggccgggcgt tcgccgcgcg cggcggccag gaacggggct tcgggcagct
    10801 c
//
